Antimicrobial resistance (AMR) - The role of the Swedish Board of Agriculture - prevention coordination prudent use - SVA
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Antimicrobial resistance (AMR) The role of the Swedish Board of Agriculture - prevention coordination prudent use Lena Hellqvist Björnerot Deputy CVO 2019-05-14
Outline • Background, the importance of AMR, global views • OIE - and EU coordinaton • The Swedish model and strategy historically prevention & healthy animals reduce the need & prudent use cooperation legislation, control monitoring • One Health, Intersectoral Coordination Function • Summary 2019-05-14
Swedish Board of Agriculture (SBA) SBA is the Government's expert authority in the agro-food sector - responsible for all matters related to agriculture & horticulture Task - to fulfil the overall objectives of the political sectors of agriculture, food & fisheries Aim - Sustainable agriculture, good livestock husbandry & a varied agricultural landscape Being prepared for crisis 2019-05-14
SBA´s mission Ensure good animal health among kept animals Prevent spread, and control, of infections among kept animals Ensure a good animal welfare Work for food security and consumer trust for our part of the food chain Sustainable food production Profitability in farming 2019-05-14
A big threat to humanity... WHO: Antibiotic resistance, along with the climate issue, is one of the biggest threats to global health, food security and development today! Global action plan to tackle antimicrobial resistance – 2015, in Tripartite collaboration with The Food and Agriculture Organisation (FAO) and The World Organisation for animal health (OIE). http://www.who.int/antimicrobial-resistance/global- action-plan/en/ 2019-05-14
A big threat to humanity... United Nations General Assembly in New York September 2016: A political declaration endorsed by Heads of State signaled the world’s commitment to taking a broad, coordinated approach to address the root causes of antimicrobial resistance across multiple sectors, especially human health, animal health and agriculture. Namely all UN countries support the Global Action Plan against Antibiotics Resistance, produced by the WHO in cooperation with FAO and OIE https://www.un.org/pga/71/wp-content/uploads/sites/40/2016/09/DGACM_GAEAD_ESCAB-AMR- Draft-Political-Declaration-1616108E.pdf 2019-05-14
A big threat to the economy... The World Bank estimates that antimicrobial resistance (AMR) has the potential to lead to economic consequences in the dignity of the financial crisis 2011 by the year 2050. The World Bank's report also shows that low and middle income countries are often the hardest hit. http://documents.worldbank.org/curated/en/32331149 3396993758/pdf/114679-REVISED-v2-Drug- Resistant-Infections-Final-Report.pdf 2019-05-14
‘Review on Antimicrobial Resistance. Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations. 2014.’ If increase and spread of AMR continues in the same way & rate in 2050… 2019-05-14 https://amr-review.org/home.html
Use of antimicrobials in livestocks Increased demand for animal protein and shift to large- scale farms – use may increase with 67% by 2030 2019-05-14 Comment – urging for a sustainable production
One health approach is necessary All sectors must work together at all levels…. 2019-05-14
FAO http://www.fao.org/search/en/?cx=018170620143701104933%3Aqq82jsfba7w&q=antimicrobial+resist ance&cof=FORID%3A9&siteurl=www.fao.org%2Fabout%2Fen%2F&ref=www.fao.org%2Fhome%2Fen%2 F&ss=7432j3340152j24 2019-05-14
OIE - World organisation for Animal Health OIE Activities against AMR http://www.oie.int/fileadmin/Home/eng/Media_Center/docs/pdf/PortailAMR/EN_OIE- AMRstrategy.pdf 2019-05-14
OIE 4 main objectives against AMR • Improve awareness & understanding • Strengthen knowledge through surveillance & research • Support good governance & capacity building • Encourage implementation of international standards 2019-05-14
2019-05-14
AMR in OIE TERRESTRIAL & AQUATIC CODES Chapter 6.7. Chapter 6.1. Introduction to the Introduction to the recommendations for recommendations for controlling antimicrobial controlling antimicrobial resistance resistance Chapter 6.8. Chapter 6.2. Harmonisation of Principles for responsible national antimicrobial and prudent use of resistance surveillance antimicrobial agents in and monitoring programmes aquatic animals MANUAL OF Chapter 6.9. Chapter 6.3. Monitoring of the Monitoring of the DIAGNOSTIC TESTS quantities and usage quantities and usage patterns of antimicrobials patterns of antimicrobial AND VACCINES FOR agents used in food agents used in aquatic TERRESTRIAL producing animals animals Chapter 6.4. ANIMALS Chapter 6.10. Development and Responsible and prudent harmonisation of national Chapter 2.1.2 use of antimicrobial antimicrobial resistance Laboratory agents in veterinary surveillance and medicine monitoring programmes methodologies for for aquatic animals Chapter 6.5. bacterial Chapter 6.11. Risk analysis for Risk analysis for antimicrobial resistance antimicrobial antimicrobial resistance arising from the use of arising from the use of antimicrobial agents in susceptibility testing antimicrobials in animals aquatic animals http://www.oie.int/en/standard-setting/terrestrial-code/access-online/ http://www.oie.int/index.php?id=171&L=0&htmfile=titre_1.6.htm http://www.oie.int/fileadmin/Home/eng/Health_standards/tahm/2.01.01_ANTIMICROBIAL.pdf 2019-05-14
OIE activities against AMR continued List of antimicrobial agents of veterinary importance, in parallel with the existing WHO list for human medicine Global database on antimicrobial agents intended for use in animals Network 2019-05-14
EU legislates & EU coordinates its positions related to OIE & other international organisations EU cooperates on OIE issues with other regions, such as Africa 2019-05-14
EU – AMR Strategy key objectives 2. Boosting research, 1. Making the development and innovation EU a best practice region 3. Shaping the global agenda 2019-05-14 https://ec.europa.eu/health/amr/action_eu_en
The Swedish animal health situation, Swedish model & AMR strategy 2019-05-14
Sweden has a unique high animal health status • Geographically favourable situation & climate • No recent wars • Financial resources • Not so dense animal population • Strict legislation • Long tradition cooperation government & stakeholders - “prevention is better than cure” • Low volume & strict control for safe trade/imports of live animals – but promoting trade of products • Animal Welfare Etc…
History of animal health activities • Tuberculosis and Brucellosis eradication schemes in 1940-60 • Organizations for insemination and bovine fertility started preventive fertility and disease control ~ 1940 • Dairy industry started preventive udder health scheme in ~1950 • Salmonella Control programme started after an outbreak 1953 • Voluntary eradication of EBL (free 2007) & BVD (free 2013) started in the 1990-ties • Eradication program for IBR, paratuberculosis, Aujeszky's Disease & PRRS 2019-05-14 Now free for most of these and several other diseases!
A composite strategy against AMR is needed Remove unnecessary use growth promoters, routine prophylaxis Reduce need keep animals healthy prevention and infection control Avoid spread biosecurity, infection control, food hygiene... Optimize use when needed correct diagnosis, selection and dose Monitoring of resistance and use LONG-TERM WORK. AWARENESS & COOPERATION AT ALL LEVELS!
Our tools • Legislation • Financial resources – to fight epizootic diseases & support programmes and projects run by farmers organisations to promote animal health • Incentives & understanding of risks and benefits • Cooperation 2019-05-14
Remove unnecessary use Antibiotics as growth promoters prohibited in SE 1986 Corresponding prohibition in EU 2006 - important to reduce and end the use globally! Avoid routine prophylaxis - only use after veterinary prescription, clinical examination and diagnosis, sampling and sensitivity analysis! - problem solving at the root! Legislation (SBA) Global standards!
Reduce need & avoid spread Healthy animals do not need antibiotics Infection prevention & control
”THE SWEDISH MODEL” AMR is not in isolation • Long tradition in Sweden of “prevention is better than cure” • Close dialogue & cooperation between stakeholders & governmental authorities • Knowledge & understanding of benefits! • Stakeholder platform, yearly meetings • Stakeholders run programs for improving animal health & biosecurity in general (pig-, cattle-, sheep-, fish- & poultry sector) • Focus on ”production diseases” – free of serious diseases • One Health • Prudent use of antimicrobials • Animal welfare 2019-05-14
Infection prevention & control (IPC) Important tool also in the veterinary medicine to - prevent emergence of healthcare associated infections* - prevent the spread of infectious agents between animals, farms & bet ween animals – humans Clean hands, working clothes, equipment… - Reduce the need of antimicrobials Mandatory for all veterinary services in Photo; Bengt Ekberg, SVA Sweden to have IPC-plans! *e.g. MRSA https://distriktsveterinarerna.se/download/18.1487953d1697560ebcfc49d3/1552654159983/Hygienguiden.pdf http://www.svf.se/sv/Forbundet/Policydokument (IPC small animal veterinary clinics/hospitals; horse practice; handling dogs & cats with specific AMR,) http://www.jordbruksverket.se/download/18.2ae27f0513e7888ce22800010291/1370040513684/2013-014.pdf
Optimize use when needed Correct diagnosis Correct substance, dose & time Guidelines & treatment recommendations - considering risks for AMR when prescribing - Mastitis policy; Guidance on medicated feed; - Swedish Veterinary Association general policy (1998) & specific guidelines for use of antibiotics in: dogs & cats; cattle & pigs; horses; sheep & goats - Medical Products Agency recommendations on antibiotic use https://saveantibiotics.se/ http://skyddaantibiotikan.se/ http://www.svf.se/sv/Forbundet/Policydokument/ https://lakemedelsverket.se/veterinara-behandlingsrekommendationer
Use & monitoring of antimicrobials • SBA is responsible for regulating the use of VMPs, risk management and the overall control - requirement for veterinary prescription - veterinarians not allowed to sell VMP - veterinary obligation to report use • SBA obligation to compile & report the sales of VMPs - Swedish Government - yearly report on sales of VMPs (including antibiotics) - ESVAC – yearly report antibiotics (Europe) - OIE (as of 2015) 2019-05-14 Working for harmonised EU legislation
Sweden - use of antibiotics Källa: Swedres-Svarm 2018 2019-05-14
Europe – use of antibiotics Sales for food-producing species, in mg/PCU, for 30 European countries, in 2016 Eighth ESVAC report 2019-05-14 Sales of veterinary antimicrobial agents in 30 European countries in 2016. Eighth ESVAC report
One health approach is necessary All sectors must work together at all levels…. 2019-05-14
The Swedish AMR Strategy - overall framework Overarching goal: Preserve the possibility for effective treatment of bacterial infections in people and animals First joint National Action Plan in year 2000 Joint work on zoonosis since 1990ties https://www.government.se/contentassets/168838e186de455ca7f e868bee92d209/swedish-strategy-to-combat-antibiotic- resistance.pdfrnment.se/information-material/2016/05/swedish- strategy-to-combat-antibiotic-resistance/ 2019-05-14
Intersectoral Coordination Function • 2012 – formalised AMR cooperation • 25 governmental authorities & organisations • National Action plan updated for 2018-2020 • Yearly forum during the European AMR-awareness day (November) • Joint communication strategy updated 2019 • https://saveantibiotics.se/ http://skyddaantibiotikan.se/ • E.g. recommendations to prevent MRSA from infected humans working with animals 2019-05-14
In summary Cooperation Prevention & control all levels disease management Animal welfare AH+PH Knowledge Prudent use of Understanding benefits antimicrobials Incentives Financing Legislation Long term cooperative work – understanding & motivation is needed to achieve a change in behaviour! 2019-05-14
It is possible! Thank you for your attention Lena Hellqvist Björnerot Deputy Chief Veterinary Officer (Deputy CVO) Department of Animal Health and Welfare lena.bjornerot@jordbruksverket.se https://www.jordbruksverket.se 2019-05-14
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