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Official Publication of the Academy of Clinical Science and Laboratory Medicine Volume 46 Issue 2 Summer 2020 Bernadette Jackson Academy President, 2020 - 2022 AGM
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contents Volume 46 Issue 1 Summer 2020 editorial............................................................................................................. 4 message from the president....................................................... 6 academy Medical Scientists in the Media................................................................................. 7 features Plagues & pandemics ............................................................................................... 8 CervicalCheck - Getting with the programme.......................................................... 10 An overview of coaching and mentoring theory...................................................... 12 Women in Science................................................................................................... 16 Page 7 cpd CPD Updates........................................................................................................... 17 CPD - the New Normal............................................................................................. 18 academy AGM 23rd july 2020................................................................................................... 19 Medical Scientists: work in the new normal............................................................. 22 Intern Medical Scientist............................................................................................ 22 Working from home.................................................................................................. 23 Return to work.......................................................................................................... 27 Page 19 Putting the studies on hold...................................................................................... 28 awards Blood Repatriation Health Innovation Hub Ireland - Spark Ignite............................ 29 Helen Ryan; HealthCare Innovation......................................................................... 30 The Mercy University Hospital, Cork, Annual Clinical Audit and Quality Improvement Day..................................................................................................... 31 industry news The Allplex 2019-nCoV (Seegene) assay: which performances are for SARS-CoV-2 infection diagnosis?............................................................................ 32 Page 40 research Multi-triazole-resistant Aspergillus fumigatus and SARS-CoV-2 co-infection: A lethal combination................................................................................................ 35 Blood Transfusion: Evaluation of electronic issue in the Republic of Ireland - Over 30 years in existence and still underutilised.................................................... 38 Improving Blood Stock Magagement: A collaborative approach........................... 40 Antimicrobial Resistance Determinants Circulating among Thermophilic Campylobacter Isolates Recovered from Broilers in Ireland Over a One-Year Period...................................................................................................... 42 health and biomedical science updates Compiled by Helen Lambkin................................................................................... 43 book review The Pull of the Stars................................................................................................. 45 Page 45 crossword..................................................................................................... 46 Summer 2020 • converse • 3
editorial I have said it so many times but these are session in May. I have included the link in extraordinary times. So many events had to the Webinar spread. As Helen Lambkin said be postponed. In our case Biomedica and in her AGM report, research is so important. our AGM, originally scheduled for April 27th, Medical scientists have access to so much as well as some planned meetings. Our data and lead on so many developments, yet AGM was held on July 23rd with a blended rarely publish this work. There are so many attendance at CUH. Over 20 attended in reasons for this, not least the very heavy person with strict physical distancing and workload of medical scientists and the absence about 35 attended by Zoom. Dr Brigid of protected time to write up this work. At the Lucey’s two year term as President came to very least medical scientists should insist on an end and she handed over the chain of being included in any published work that office, under strict distancing, to Bernadette includes benchwork in which they have been Jackson. Bernadette holds the Presidency involved. Medical scientists won some national until 2022. Bernadette, as Brigid pointed out awards recently, making a huge contribution in her address, is a passionate advocate for to healthcare. The Academy plans to capture laboratory medicine and medical scientists. the incredible work of medical scientists in I am looking forward to working with her labs across the country in setting up and and helping to support and advance delivering SARS-CoV-2. Medical scientists are her objectives. In advance of the AGM encouraged to publish their work in this. It was the Academy and MLSA issued a media Helen Barry done under difficult conditions and with great statement. This highlighted some of the urgency. The experience will be useful to have issues of concern for medical scientists and of this issue. Anne Maclellan has written recorded. clinical laboratories in this era of Covid-19. on pandemics in our feature section and Even in this “New Normal” CPD remains These issues included recruitment and also reviewed Emma Donoghue’s latest a requirement for medical scientists. The retention of medical scientists, lack of facilities novel “The Pull of the Stars”. Although it is a Academy is delivering Webinars to provide in our laboratories, career progression work of fiction, it deals with one of our most material for medical scientists to keep up to for medical scientists and the need for IT famous pandemics, the 1918 Flu. Some of date. These are recorded and can be accessed connectivity. We were delighted that this those medical scientists who returned to the by members through our website acslm. was picked up by the media and Brigid workplace have written of their experiences. ie. They provide useful material for CPD and gave a number of radio interviews. The These range from Caoimhe Lynch putting her Journal Clubs. We welcome medical scientists statement can be seen on the Academy PhD on hold to Clíona O’Shea’s experience who are willing to present their work. This can website. The Academy and MLSA made a as an intern and Anne Marie Meenan working be recorded in the comfort of your own home joint submission to the Special Oireachtas from home. I know there are so many across and edited until you are comfortable with it and Committee on Covid-19. The Oireachtas the country who have volunteered to return. then delivered. No need to perform live! report can be downloaded: https://data. In the Academy office we had a list of over Mentoring for medical scientists is a key goal oireachtas.ie/ie/oireachtas/committee/dail/33/ 70 eligible medical scientists offering to of our current and past presidents. Brigid has special_committee_on_covid-19_response/ return to the labs. I am also aware of some of written a feature piece on it for this issue and reports/2020/2020-08-05_interim-report-on- those who returned to help out during peak by way of introduction to a programme planned testing-and-tracing_en.pdf Covid-19, have decided to stay on. They will by Bernadette and our CPD officers. It was great to see so many medical be very welcome. We continue providing a notarising service scientists in the media, showcasing their great In the midst of all of this pandemic work, through our office in Kilmainham. However work and letting the public see the pivotal medical scientists still found time to publish this has to be booked through the office so role of medical scientists in the management their research and innovation. Our research we can control attendance and to comply with of this pandemic. I have captured some of section shows some recent publications. I Covid-19. the media pieces. Medical scientists are was unable to secure permissions in time Please keep in contact with us. We welcome very active on social media. This also gives to reprint work done in the Coagulation your suggestions on how we can do things the profession visibility. Please follow the Laboratory in St James’s Hospital. Mary better and your ideas for events, Converse Academy on Twitter, Facebook and Instagram. Byrne the Chief Medical Scientist there, articles, Webinars etc. Pandemic could be the general theme presented the findings at our Webinar Helen Barry, CEO Editor: Helen Barry Converse is published three times a year. It is Deputy Editor: Anne Mac Lellan utilised for information exchange, communication and continuing education, managerial and Editorial Board: scientific, of the medical laboratory scientists of Anne MacLellan, Ireland. Brigid Lucey Publication of an article does not constitute Advertising: Roger Cole endorsement by the Academy of Clinical Science Silchester Marketing Ltd. and Laboratory Medicine of the products, Tel: 01-285 9111 • Mobile: 087-2611597 techniques or organisations described therein. The Academy of Clinical Science and The Academy of Clinical Science and Laboratory Laboratory Medicine, Email: roger@silchestermarketing.com Medicine is an educational and scientific 31 Old Kilmainham, Dublin 8. Production/Design: Artworks Graphic Design organisation designed to serve as a resource Dalkey Business Centre, to advance the quality of medical laboratory Tel: 01-905 9730 17 Castle Street, Dalkey, Co. Dublin science. Fax: 01-902 2764 Tel: 01-2751707 • Mobile: 086-2611598 Members who wish to continue receiving Email: mail@acslm.ie Email: design@artworks.ie Academy publications should notify the Academy Web: www.acslm.ie Web: www.artworksireland.com of any change of address. 4 • converse • Summer 2020
message from the president Message from the President profession on National and International repatriate these services. Committees, publish research, collaborate The Academy is not just the Council - it with other clinical colleagues and still is you the members, medical scientists. manage to ensure routine and emergency We need you to be more actively involved, diagnostic services are expertly provided more visible, grasping and demanding 24/7/365. opportunities to demonstrate your value The ongoing COVID – 19 pandemic and expertise in workplaces at all levels. has provided the opportunity for medical This means Laboratory Managers ensuring scientists to step into the limelight – indeed workplaces are sites of learning, Chief without your tireless work, Ireland would Medical Scientists encouraging young, not be at the current phase of re - opening enthusiastic and highly qualified graduates and considering a new normal. Your work (many winning awards both nationally and in microbiology departments across the Internationally) to contribute, follow up, country to verify multiple analytical systems research and be enquiring. Finally you for a new virus described and reported in the scientist– never underestimate your January 2020 has been commendable. contribution and continue to learn and Your additional efforts, including sharing of grow in your knowledge, to support the information, advice and reagents between patient to a rapid diagnosis, appropriate colleagues and sites, advising nationally on treatment and ongoing optimal and both equipment and reagent procurement standard driven, care pathways. Educate I t is my greatest honour to accept the role has been outstanding and self less. yourself in that which you do not know, of President of the Academic Body of You have also actively become involved keep learning, listen to and learn from other my profession - the Academy of Clinical and lead processes to ensure standard clinical colleagues, question everything? Science and Laboratory Medicine. laboratory quality requirements from For myself, I will be ably supported by a The Academy – representing medical labelling to tracking are embedded into the knowledgeable team of Council members, scientists – those unseen, largely unknown SARS – CoV-2 analysis pathway. including past Presidents, Advisory Body scientists, working in Clinical Diagnostic Of course COVID – 19 does not only Committee members, CPD officers, office Laboratory Services, who provide analyses, require diagnostic microbiological staff and the CEO. Many of these medical results, diagnoses and expertise to support molecular focus, but rather ongoing scientists who while leading their own the patient, with diverse presentations - monitoring using a variety of diagnostic laboratory services and departments, still across many Pathology disciplines. tools across multiple laboratory specialities find additional time, to reflect on the bigger Medical scientists who keep the public including clinical chemistry, haematology, picture, continue to have a passion for this and private hospital wheels turning by coagulation and indeed my own current profession and the expertise of medical providing essential Clinical Diagnostic speciality of POCT. Restructuring of staffing scientists, and work tirelessly toward the Laboratory services, 24/7/365. and flexibility, ensured services did not fail, wider recognition of medical scientists and Medical scientists – who work within and but rather were fully supported to continue single spine structures, late into the night have driven the implementation of quality both in hours and out of routine hours, to and on their weekends. They also attend management systems across laboratory ensure rapid turnaround times. HSE, Department of Health meetings and services in Ireland, to ensure continuing Having stepped up and also stepped National Committees on your behalf. We compliance with ISO 15189 and 22870 into the limelight, it is now time to continue will continue to promote and demand Laboratory Accreditation standards and to ensure our real value in the diagnosis collaboration with the Department of participate in an annual inspection process. and ongoing management of patient care Health, HSE and other clinical groups. As I reflect on my own journey in my is no longer overlooked. There are many I too will be working tirelessly on your profession, commencing many years ago who would presume to understand our behalf. I know and believe in the value of in DIT, Kevin St and fondly revisited, earlier services, underestimate our expertise our expertise, clinically, analytically, and this year on the open day, with one of my and presume quality laboratory service diagnostically, supporting routine, and classmates, I am struck by the journey of provision and interpretation, is a simple out-of-hours clinical diagnostic laboratory our profession, a journey led by visionary enough process of automation (if only services 24 /7/365. I will be working to scientists. !!!). How many days do we hope for new ensure your expertise and data is not Indeed at one time in the distant past, we assays that perform correctly at clinical usurped by others but rather through were considered technical with a vocational cut off points, are not flawed and do mentoring and other novel pathways education however, as we all know, our not require manufacturer modifications, including research in chronic disease education from that time to the current day, IT systems that deliver without multiple management, and ED attendance has been focussed on clinical diagnostic novel workarounds and new automated prevention and greater visibility on laboratory services for patients, across all equipment that is fit for purpose. student clinical placements to ensure pathology departments. As a testament to However, and unfortunately for many your invaluable contribution to the patient our expertise, some 80% of BSc graduates young women in Ireland and their families, clinical pathway and diagnostic journey is working in clinical diagnostic laboratory these presumptions to know our service, recognised and acknowledged. services, attain a minimum of an MSc, disregard our expertise and ignore our and many additionally add PhD, FRCPath, advice, have already and continue to MBA, Bioinformatics, IT, Six Sigma and remind us, that the decisions to outsource other qualifications to their CVs. Cervical Services abroad were flawed. Many medical scientists represent their Indeed it remains a not so simple task to 6 • converse • Summer 2020
academy Medical Scientists in the Media Irish Examiner, Abigail Salmon by Harry Walsh h.walsh@donegalnews.com Testing times: Dr Jacqui Clarke, The science of Donegal Daily fighting Covid-19 “IT was like going to war. We were all scared but we had to stand up and meet the Covid-19 Pádraig Hoare pandemic head on.” It has been a baptism of The words of Dr Jacqui Clarke, Pathology fire for the Chief Medical Laboratory Manager, Letterkenny University Scientist of Microbiology Hospital, strike a chord. at St Vincent's University “What we learned as a department is invaluable. So many younger Hospital (SVUH) in Dublin. members of staff have developed, matured and really shown what Abigail Salmon, Chief Medical Scientist at St Vincent's University Hospital they can do. It was marvellous to see so many young people at the Dublin, with colleague Aoibheann Sally. Pics: Moya Nola start of their careers really show what they’re made of in terms of their knowledge, application and ways that we do things,” she said. Severe lack of medical scientists The Medical Independent in Irish Covid-19 highlights need for more laboratories “There is a severe shortage of medical medical scientists in hospitals scientists in Irish laboratories, which Speaking at the Academy’s AGM today, Dr Lucey highlighted the need means longer testing turnaround to invest in medical scientists and hospital laboratory infrastructure. times for patients. The problem has been amplified by the outbreak of the “Laboratories are constantly fire-fighting and the demands of Covid-19 Covid-19 pandemic, with hospitals struggling to fill key posts, despite demonstrated the lack of investment. The pandemic shows that the required heavy advertising and promotion. Chief medical scientist in microbiology expertise is available in medical scientists, but capacity and infrastructure at St Vincent's University Hospital in Dublin, Abigail Salmon, said the stark are sadly lacking. Laboratories account for 5 per cent of the hospital nature of the lack of staff was apparent before the current crisis.” budget, yet laboratory results inform 70 per cent of clinical decisions. “Medical scientists must be part SUNDAY, MAY 24, 2020 - 23:05 PM Pádraig Hoare of an immediate planning process with the HSE and should have a formal link and access to the national public health emergency Business Post team (NPHET). They understand the entire testing pathway and the Dr Brigid Lucey, need for quality management across the continuum of patient care.” explaining testing The calls were also made as part of validation criteria. a joint submission to the Oireachtas special committee on Covid-19 by the Academy and the Medical Laboratory Scientists Association. MEDIA COVERAGE of joint statement from the Academy and MLSA Yvonne Lynagh, Chief Medical Scientist, • Newstalk news: (with distribution to Today FM, Q102 and main Virology, St James's local stations across the country.) Hospital, who was on • Medical Independent: https://www.medicalindependent.ie/ RTÉ recently. covid-19-highlights-need-for-more-medical-scientists-in-hospitals/ • Activelink: www.activelink.ie/community-exchange/news/76581 • Kildare FM: https://kfmradio.com/news/23072020-0914/listen- hospitals-urged-employ-more-scientists-their-labs Pat Mulhare talks to Matt Cooper on Laboratory Testing: Tuesday 28th April) Listen back www.acslm.ie Summer 2018 • converse • 7
feature Plagues & pandemics I nterspersed struggling through the current pandemic: amongst the the world has faced fearful bacterial and histories which viral threats and recovered. Optimism as celebrate the battles, Covid-19 appears to come under control sieges, triumphs and in Ireland must, of course, be tempered politicking of the elites by an acknowledgment of the death toll such as the artistocracy, and the difficulties along with the fear and Royalty, the Church, the struggle. Governments and armies, Even though we have a better are accounts of frightening understanding today of the cause of the and lethal contagions, poorly latest pandemic, with the SARS-CoV-2 understood but known to be virus quickly sequenced, many of the passed from one human to public health measures that have been another. From BC to the present adopted – quarantine, isolation, hygiene day, plagues and pandemics – would be very familiar to our ancestors. have interrupted civic life, As we debate whether to cover our emptying villages, towns and faces in public, the iconic masks of the cities, stopping commerce plague doctors spring to mind. These and trade, confining people beaked masks, rendering the doctor to their homes, and challenging anonymous, contained herbs supposed healthcare providers. Germs were an to ward off the miasmas that were unintentional source of genocide when thought to cause the plague. The head new parts of the world were ‘found’ to toe covering worn by the doctor is bringing together European germs and the forerunner of the hazmat suit while immunologically naïve native populations the rod was to fend off victims who tried in the ‘new world’. to get too close (the forerunner of the 2 From the Plague of Athens, which metre rule?). occurred in 430 BC to the present day The enumeration of deaths on a Covid-19 pandemic, the world has been regional basis is not something that subject, periodically, to waves of infectious originated with NPHET or the WHO. The diseases which often crossed borders and same fascination with numbers was even continents. The histories of plagues evident in the 1600s – bills of mortality for and pandemics may provide something the various parishes provided the figures of a comfort to today’s medical scientist during the great plague of London and Plagues and Pandemics throughout history Plague of Athens, 430 BC - Estimated 75,000-100,000 dead Antonine Plague, AD 165-180 Estimated 5 million dead - Plague of Justinian, AD 541-542 May have been Yersinia pestis Estimated 30 to 50 million dead The Black Death, 1346-1353, Asia to Europe, Yersinia pestis. - Estimated 25-50 million dead American plagues, 16th century, Europe to America ‘genocide’ - Great plague of London, 1665-1666 Estimated100,000 dead A physician wearing a 17th century plague preventive. Credit: Wellcome Spanish flu, 1918-1920 - Estimated 40 million dead Collection. Attribution 4.0 International Covid19, 2019-2020 - Number dead to date: 716,075 (8th August 2020, WHO) (CC BY 4.0) 8 • converse • Summer 2020
feature their house was shut up. Rather than house and other places) be admitted to voluntary self-isolation, two watchmen common use till their coaches be well were appointed, one for the day and aired, and have stood unemployed by one for night to ‘have a special care that the space of five or six days after such no person go in or out of such infected service.’ houses whereof they have the charge, Defoe’s narrator has some upon pain of severe punishment. And suggestions to add to the public the said watchmen to do such further response. He warned about the infection offices as the sick house shall need and being brought into homes via food require.’ This is somewhat reminiscent of shopping and also how more hospitals the Chinese response to Covid19. for the infected were required: ‘(1) Defoe details how women searchers The infection generally came into the were appointed to seek out dead bodies houses of the citizens by the means of and ensure proper burial. Searchers their servants, whom they were obliged were not to carry out any other business: to send up and down the streets for ‘That no searcher during this time of necessaries; that is to say, for food or visitation be permitted to use any public physic, to bakehouses, brew-houses, work or employment, or keep any shop shops, &c.; and who going necessarily or stall, or be employed as a laundress, through the streets into shops, markets, or in any other common employment and the like, it was impossible but that whatsoever.’It was important to get they should, one way or other, meet with the numbers right so a number of distempered people, who conveyed the Chirurgeons were appointed to work fatal breath into them, and they brought only with plague victims; their task it home to the families to which they was to stamp out the ‘great abuse in belonged. (2) It was a great mistake that while the method of dissemination of misreporting the disease.’ such a great city as this had but one the information differed, the public was Nurse-keepers, who looked after the pest-house…’ equally eager to hear ‘today’s numbers’. sick, were to observe an isolation period: He also mentioned the effects of For me, one of the most compelling ‘If any nurse-keeper shall remove herself the plague on everyday life: ‘all trades reads when it comes to plagues and out of any infected house before twenty- being stopped, employment ceased: pandemics is an account of the great eight days after the decease of any the labour, and by that the bread, of the plague of London written by Daniel person dying of the infection, the house poor were cut off; and at first indeed the Defoe, better known as the author of to which the said nurse-keeper doth so cries of the poor were most lamentable Robinson Crusoe. While Defoe was not remove herself shall be shut up until to hear, though by the distribution of an eye witness, this fictive account was the said twenty-eight days be expired.’ charity their misery that way was greatly extensively researched, is informative Bedding and apparel were to be aired abated.’ Change the archaic language, and easy to read. For more ‘real’ before re-use after death or infection. and extracts of Defoe’s Journal are eerily accounts, try Samuel Pepys’ diary or In a response that will resonate with similar to the online media accounts the dryer London’s Dreadful Visitation, a anyone who had a loved one pass away that we have been reading daily on our book of the “bills of mortality” and all the recently, it was ruled that ‘No neighbours phones as Covid19 unfolded. There is burials in the city compiled in 1665. nor friends be suffered to accompany nothing new under the sun? In his journal of the plague year, the corpse to church, or to enter the Anne Mac Lellan has a PhD in the readily available online, Defoe recounts house visited, upon pain of having his history of medicine and is a surveillance doctors and quacks selling ‘Infallible house shut up or be imprisoned. And scientist (jobsharing) in Connolly preventive pills against the plague’, that no corpse dying of infection shall be Hospital, Dublin ‘Neverfailing preservatives against buried, or remain in any church in time of the infection,’ ‘Sovereign cordials common prayer, sermon, or lecture.’ References: against the corruption of the air.’ ‘Exact There was little debate over stigma: Daniel Defoe’s Journal of the plague year, regulations for the conduct of the body practicality trumped sensitivity with every available to read online: http://www.gutenberg. in case of an infection.’ ‘Anti-pestilential visited house marked with a red cross org/files/376/376-h/376-h.htm pills.’ ‘Incomparable drink against the ‘of a foot long in the middle of the door, Stacking the Coffins: influenza, war and plague, never found out before.’ The evident to be seen, and with these usual revolution in Ireland, 1918-19, Ida Milne, marketplace, then as now, was quick printed words, that is to say, “Lord, have Manchester University Press, 2018. to respond to perceived needs, while mercy upon us,” to be set close over the The Greatest Benefit to Mankind: a medical playing to people’s fears. Anyone for same cross, there to continue until lawful history of humanity from antiquity to the present, bleach or chlorohydroquinine? opening of the same house.’ Roy Porter, Fontana Press, 1999. Defoe details the public health Just as issues with public transport The Western Medical Tradition 1800-2000, response with examiners appointed to and shared transport have emerged W.F. Bynum, Anne Hardy, Stephen Jacyne, every parish, to learn who was ‘sick of with Covid19, during the plague it was Christopher Lawrence, E. M. (Tilli) Tansey, infeciton’ and to ‘command restraint of ruled ‘That care be taken of hackney- Cambridge University Press, 2006. access until it appears what the disease coachmen, that they may not (as some https://www.theguardian.com/books/ shall prove.’ If the dreaded plague was of them have been observed to do after booksblog/2020/may/19/beyond-daniel-defoe- infecting any member of a household, carrying of infected persons to the pest- the-real-journals-of-the-plague-year Summer 2020 • converse • 9
feature CervicalCheck Getting with the programme! Dr Dave Nuttall, PhD, MPhil, DipRCPath, CSci, FIBMS - CervicalCheck Clinical Laboratory Advisor Definition of population disease is falling and that is due to the participant management protocols. All screening various cervical screening programmes these requirements must be underpinned The aim of population screening is to in operation worldwide. by a strong foundation of quality detect a given disease in an individual Cervical disease progresses through assurance (QA) to ensure the greatest before the symptoms of that disease several intra-epithelial stages prior to benefit to the individuals served. appear, for example, cervical screening invasive cancer and the condition is The woman has her part to play also aims to prevent cervical cancer through detectable in these early stages and and regular adherence to screening early detection of precancerous changes treatment prior to invasion has a high invitations and attending for the test is on the cervix. Early detection of disease success rate. known to be vital in successful screening. has several patient benefits, including: Previously, cytology was performed • Increasing the treatment options on screening samples to detect these An overview of CervicalCheck precancerous changes associated The CervicalCheck cervical screening available to the patient with the early stages of the disease. programme commenced on 1st • Reducing invasiveness of treatment In recognising oncogenic HPV as the September 2008 following a pilot • Reducing morbidity and mortality prime cause of cervical disease, many programme in the mid-west of Ireland. Its • Improving survival rates programmes are screening for the primary goal is to reduce the incidence • Improving quality of life presence of the high risk variants of the of cervical precancer by screening a HPV virus, in a risk stratification modality, target population of approximately 1.33 How is a population screening and positive samples then have cytology million women. The eligible screening programme introduced? performed in order to assess the severity population consists of individuals with A population screening programme for of any disease, thus: a cervix within the age range of 25-65 disease should satisfy the Wilson and • HPV test = Test of risk of cervical years. Jungner (1968) criteria for a screening disease programme which help ensure that the • Cytology = Test for cervical disease QA in laboratory cervical proposed programme achieves those health benefits intended from screening. screening What makes an effective Laboratory standards and requirements cervical screening for QA in cervical screening encompass Aetiology of cervical cancer programme? the following disciplines: and screening for the disease Fundamentally, the programme must • Cytopathology The natural history of cervical disease identify and invite eligible women and • Molecular HPV Testing is now much better understood and the it is vital that they attend for the test to • Cervical Histopathology role of Human Papillomavirus (HPV) as realise the potential health benefits. the causative agent is beyond dispute. CervicalCheck aims for 80% attendance These laboratory services are Cervical cancer is an important health from invitation for screening and commissioned by the National problem, with 15.1 cases diagnosed maintains a register of eligible women Screening Service (NSS) on behalf of and 4.3 deaths per 100,000 reported invited at regular intervals for their CervicalCheck. Service specifications in Ireland each year. In the EU, the screening test. with detailed and explicit requirements for disease affects 11.3 women with 3.7 The screening programme must compliance with the latest programme deaths per 100,000 (2012 European provide appropriate information to QA standards are documented and age-standardised rate) annually. The participants. There must be clear, agreed via service contracts and good news is that mortality from cervical evidence-based testing, treatment and memoranda of understanding. 10 • converse • Summer 2020
feature Whilst the clinical governance for check that laboratory facilities, records advent of HPV primary testing and screening participants resides with and procedures are compliant with QA centralisation, the number of cervical CervicalCheck, the clinical responsibility standards. Interim inspections can be cytopathologists in the UK has declined for CervicalCheck screening samples carried out where deemed necessary sharply. These factors, combined with for cervical cytology and molecular (for example, as a result of an identified the increased number of non-medical HPV testing is the responsibility of the non-conformance). cytopathologists (who currently cannot cytopathology service under the lead work in Ireland), have further decreased pathologist. This is primarily because The future of laboratory the recruitment opportunities for the Irish the largest interaction by far between cervical screening services in service. laboratory and clinical services is with Ireland cytopathology and histopathology via Laboratory cervical screening services in Introducing the Consultant colposcopy multi-disciplinary team (MDT) Medical Scientist Ireland are at a watershed. The transition meetings. However, the QA standards The pressures on medical histo/ to a molecular HPV primary screening require that access to virology specialist cytopathologists were recognised test heralds a new era in the detection advice is available. in the UK in the 1990s, which led to of cervical precancer and a combination Irish screening laboratories must the development of the Consultant of state-of-the-art automated molecular be accredited to the ISO 15189:2012 Biomedical Scientist (CBMS) role. A assays and traditional morphological “Standards for the Medical Laboratory”. CBMS is a non-medical consultant analysis requiring highly skilled scientists Laboratories providing services for specialising in defined fields within offers an improved service to the women CervicalCheck that are outside of pathology. The role was created by of Ireland as well as exciting career the EU must have accreditation to the Institute of Biomedical Science opportunities for medical scientists in the appropriate standards within the (IBMS)/Royal College of Pathologists Ireland. country of origin of the contracted Conjoint Board – initially in cervical The Health Service Executive has laboratory. The scope of the laboratory been planning for a National Cervical cytopathology, and now extended accreditation must include HPV primary Screening Laboratory (NCSL) for some practice includes diagnostic cytology, testing with reflex cytology and the HPV time and the project is progressing. One gastro-intestinal, cervical and assay of choice must be approved by of the workstreams is concerned with ophthalmic histopathology. CBMSs play CervicalCheck. the provision of sustainable staffing to an integral role in supporting laboratory Bethesda terminology is the standard deliver a high quality molecular HPV/ cervical screening services, thus: in use for cervical cytopathology cytology service. • Reporting abnormal samples morphology reporting. Every result for a • Performing case reviews for MDT test is accompanied by a management meetings recommendation – the recommended Sustainable staffing for the • Training pathology specialist next step for the woman in the screening NCSL registrars programme. HPV primary screening provides new • Can now take on the Clinical Lead roles for medical scientists allowing role for the laboratory multi-skilling of the workforce, whilst Cyto-histological correlation making the most of transferrable skills. The CBMS is qualified to Masters as a “gold standard” To be successful, robust workforce degree level, with a minimum number Histology results received by the planning for the new service is required. of years’ experience in the relevant Cervical Screening Register are used The combination of new and old discipline. Attendance at a recognised as the “gold standard” to perform screening tests is an opportunity to training course is mandatory as is a cyto-histological correlation to measure extend the role of the medical scientist, minimum period of supervision – usually and monitor programme performance. and this is to be welcomed, but delivery via shadow reported cases supported Key Performance Indicators (KPIs) are of this goal will require access to the by a nominated consultant pathologist, calculated for the laboratory, these appropriate training and development. who is approved by the examination include: Training schemes need to embrace board. Finally, success in the • HPV positive rates for primary care recent advances in molecular tests for appropriate examination, which includes and colposcopy samples disease as well as established laboratory a practical element of microscopy and • Sensitivity and Specificity technologies. In the meantime, the case review, allows the medical scientist • Positive Predictive Value (PPV) NCSL will need cytologists – currently to attain consultant status along with the • Abnormal Predictive Value (APV) a limited resource – and consultant opportunities and responsibilities of the • Total Predictive Value (TPV) medical staff specialising in cervical grade. cytology are simply not available. This grade of staff was a success QA audits of laboratory Ireland is a small island, with limited story in the UK, and the CBMS is now services numbers of specialised medical recognised as a valuable member of CervicalCheck standards require that pathology staff. Increased demand, the clinical pathology team. Extending on-site QA audit visits are conducted at combined with new technologies the career expectations for Medical least every 2 years. Provider laboratories and specialisation, has resulted in Scientists in Ireland and enhancing the were last audited in 2019, prior to the increased pressures on an already prospects of the role will attract high introduction of HPV primary testing and limited workforce. There are currently achieving individuals and, in turn, will further visits are anticipated once the no medical trainees in cervical contribute positively to sustainable new programme has stabilised. The visits cytopathology in Ireland and, with the pathology services for the future. Summer 2020 • converse • 11
feature An overview of coaching and mentoring theory Dr Brigid Lucey Introduction and that the human is always directed to someone or some- Mentoring has been defined in one paper as a dyadic, face- thing outside of himself: “the more he forgets himself, the more to-face, long-term relationship between a supervisory adult human he is and the more he self-actualises”. Frankl believes and a novice student that fosters the mentee’s professional, that self-actualisation is not actually an aim at all, as the “more academic or personal development (Donaldson, Ensher, & he would strive, the more he would miss it” and that self-actu- Grant-Vallone, 2000). A clear definition for coaching is more alisation is a side-effect of self-transcendence. difficult to find in the available peer-reviewed literature and Being given the role of mentoring a colleague therefore pro- often seems to encompass the words mentoring and counsel- vides what is a privileged opportunity to fulfil the highest of the ling. Usefully, in one case it has been described as a method needs of the mentor themselves. It does suggest, however, to allow unlocking a person’s potential to maximise their own that the stage of professional and personal development that performance (Grant et al., 2006). the mentor is afforded through their work may have a bear- The facilitation of the development of others is a higher ing on whom in the workplace they are suitable to mentor. It calling, which requires the facilitator, mentor or coach to be in seems likely to be the case that a whole series of intercon- a position from which this is possible. Maslow’s hierarchy of nected mentors and mentees is what is needed, and this on a needs (Maslow, 1943) outlines the order in which any individ- continual basis. ual’s needs must be met, from the basic security needs as a It must be stated here that an exploration of the absolute priority, to the actualisation of the self which may be attained need for ethically sound behaviour in the mentor that guar- after the other needs have first been met. This original model antees putting the interests of the mentee first is beyond the was followed by Maslow’s expanded form of this principle, scope of this article, but its importance is implicit throughout. which is shown in Figure 1. This expanded plan shows the actualisation or facilitation of others placed above the actual- Maslow's Motivation Model isation or the realisation of the ambitions of the self, in what has been termed transcendence. Maslow’s own definition of transcendence was as follows: Transcendence refers to the very highest and most inclusive or holistic levels of human Growth Needs consciousness, behaving and relating, as ends rather than means, to oneself, to significant others, to human beings Trancendence in general, to other species, to nature, and to the cosmos Self Actualisation (Maslow, 1971). It should also be mentioned here, howev- er, that from his ongoing studies, regarding the structure of Aesthetic Needs his hierarchy, Maslow (1987) proposed that the order in the hierarchy “is not nearly as rigid” as would be implied from Cognitive Needs the diagram in Figure 1 (1971). A large study conducted by Deficiency Needs Tay & Diener (2011) tested Maslow’s theory by analysing the Esteem Needs data of 60,865 participants from 123 countries, representing Belonging and Love Needs every major region of the world. The survey was conducted from 2005 to 2010. They stated from their findings that the Safety Needs emergent ordering of need fulfilment for psychosocial needs was consistent across country conditions, thereby validating Physiological Needs Maslow’s upper deficiency and all of the growth needs, but that the fulfilment of basic and safety needs was contingent on country membership. In the context of a profession, it is likely Figure 1. Maslow’s hierarchy of needs (McLeod (2017) https://www.simplypsychology.org/maslow.html that the basic or safety needs are those that might be expect- ed to be met, or at the least, defended by a Trade Union. The psychosocial needs might be expected to fall within the remit Coaching and Mentoring models of the mentor, among others, however. As to self-actualisation, There are key mentoring and coaching theory and practice it is interesting that Victor Frankl, in his book Man’s Search for experts, whose principles underpin those of many others. Meaning (1946) tells us that “the true meaning of life is to be One such mentoring expert is Carl Rogers a psychologist and discovered in the world rather than in man or his own psyche” psychotherapist who was nominated for a Nobel peace prize 12 • converse • Summer 2020
feature in 1987, for his work with intergroup conflict in South Africa Coaching to success through the GROW model (Figure 3) is and in Northern Ireland. Rogers is known for practicing what another way in which the learne r might develop. This model, he has termed unconditional positive regard, which he has developed by John Whitmore in the 1980s, author of Coach- defined as accepting someone without negative judgment of ing for Performance (Whitmore, 1992), provides a process for basic worth (Rogers, 1980). Earlier, Rogers had stated that a encouraging learning, action and growth, the aim of which is person cannot teach another person directly and that a person to unlock people’s potential to allow them to self-actualise. can only facilitate another’s learning (Rogers, 1951). Within One aim of this method was to learn through enjoyment and to the teachings of Rogers is the personality theory, which states engender a sense of purpose in the learner. that everyone exists in an ever-changing world of experience in which they themselves are at the centre. Each person reacts and responds based on their perception and experience. The belief, therefore, is that the actions of the mentee are more important than those of the mentor. (Rogers, 1951) In line with the teachings of Carl Rogers, the teachings of Chris Argyris are based on the foundation of Argyris’s funda- mental faith in human nature. Argyris believed that organisa- tions depend on people and that the personal development of people can be inherent to their work, and through his thinking, an effective mentoring style was developed, in which a mentor may help a mentee (and themselves) to develop both person- ally and professionally. Double loop theory represented a major leap forward in addressing the difference between limited versions of improve- ment in organisations through learning, and a more profound view of a much-extended version of increased improvement. This is based upon a theory of action outlined by Argyris & Schön (1974). An important aspect of the theory is the distinc- tion between an individual’s self-understood theory and their actions, and their recognition of this dichotomy as a basis for Figure 3. The GROW model (Whitmore, 1992) continuous improvement via double loop learning, which is shown in schematic form in Figure 2 (Bryant, 2009). In 1984, Kolb, published a seminal book entitled Experiential Learning: experience as the source of learning and development. This book essentially worked on the principle that a person would learn through discovery and experience. This is summarised in a schematic diagram in Figure 4. Figure 2. Schematic diagram by Bryant (2009) of what is meant by double-loop learning as described by Argyris & Schön (1974) This thinking by Argyris and Schön included a belief that organisations can block employees from reaching their maximum potential, described as ‘when organisational error is detected and corrected in ways that involve the modification of underlying norms, policies, and objectives’. Furthermore: ‘Most organizations do quite well in single-loop learning (when the detection and correction of organizational error permits the organization to carry on its present policies and achieve its current objectives but have great difficulties in double-loop Figure 4. Schematic diagram of Kolb’s experiential model learning)” (Argyris and Schön 1974). Their double-loop learn- cycle ing theory unlocks the potential inherent in an organisation https://co.pinterest.com/pin/303430093623097311/?amp_ when a broader vision is embraced within its management and client_id=CLIENT_ID(_)&mweb_unauth_id=%7B%7Bdefault. within other employees. session%7D%7D&from_amp_pin_page=true Summer 2020 • converse • 13
feature Experiential learning theory provides a model of the learning (and coaching) process and is in line with how we might expect to learn, grow and develop. The theory is called experiential learning to stress the fundamental role that experience plays in the learning process. In healthcare in Ireland as we know, in recent years, an emphasis is placed on reflective practice following experiential learning, in a continuous professional development cycle, (that is largely self-monitored) and Kolb’s model is very much reflected in this practice. Another mentoring authority, Senge, with others, developed the Fifth Discipline Fieldbook (1990), to act indicated. as a guide to an educational institution. This guide was Figure 5. Phases of the mentoring relationship (Lane & based on Senge’s five principles for learning: personal Clutterbuck, 2004) mastery, mental models, shared vision, team learning and systems thinking (Zachary, 2005). Senge’s intention There have been different permutations of mentoring is that this model should foster deep thinking and he suggested over the years. These include team and says in his book that “we are talking about how people sequential mentoring, for example. In team mentoring, the create new ways of working together”. Part of his thesis team leader would mentor group members who also mentor is about changing people’s thinking and the way in one another (Williams, 2000), and sequential mentoring, which people see the world. Senge talks about our where a mentee may have a series of mentors (Baugh & assumptions about others that may prevent us from Scandura, 2000). seeing our colleagues as essential learning allies, and thus preventing us from bringing about positive change. In mentoring, one of the challenges for the mentor Discussion and Conclusion is in managing to provide active listening and not to It is likely that the greatest benefits to the mentee will come superimpose the mentor’s view of the mentee’s situation about when their actions resonate with the mission of their during meetings. The points made in Egan’s skilled organisation. The self-acknowledgment of mentoring by and helper model are very instructional here and include of ourselves in our daily working lives, in a reflective way, exploration, challenging and action planning (Egan, would help us to improve our skills in this regard. A per- 2013). The development of a mentoring system should son’s own search for meaning is also made easier through ideally be preceded by mentor training. Whether mentor reflection on this fact, perhaps. Furthermore, as taught by training is provided to the prospective mentor prior Senge (1990), organisations learn through the learning of to taking on a mentoring role or not, it might also be individuals. This must be as true for the CEO as for the helpful to have an observer present for the mentor in the student, and which makes effective communication, univer- early stages of the mentoring processes, as there are sal respect, teaching and mentoring vital. Senge’s teaching challenges inherent in trying to learn objectively to be a (1990) includes the wisdom that for any of us a state of skilled helper while focusing on the actual matters being personal mastery includes the realisation that the reward is outlined and expanded by the mentee during a meeting. the journey. Such a climate of mentoring could foster the Klasen and Clutterbuck (2002) suggest that mentoring best environment for meeting the changing needs of an involves an integrated approach combining four individual. development approaches: coaching, counselling, One of the current missions of the Academy is to immi- networking/facilitation, and guardianship. These nently set up a support for mentoring of its members at all incorporate both intellectual and emotional needs of stages of their careers. The Advancement and Engagement the mentee. It is a process whereby the needs of the Advisory Body are demonstrating their usual innovative ap- relationship are dictated by the mentee and not the proach at the moment, for new members of the profession, mentor. (Klasen and Clutterbuck, 2002). This mention as one example. Watch this space! of both coaching by and mentoring together by Klasen and Clutterbuck (2002) suggests the need for a how-to- References do-it approach at the start of the process of facilitating Argyris C & Schön D. (1974) Theory in practice: Increasing professional another’s development. Coaching in this context effectiveness, Jossey-Bass, Wiley, CA, USA. suggests that the organisation must have principally Baugh S & Scandura TA. (2000). The effect of multiple mentors adopted a Theory Y approach rather than a Theory X on protégé attitudes toward the work setting. J Soc Behav approach from McGregor’s model (McGregor, 1960) in Personal;4:503-521. which the organisation views the individual not as a cog Bryant (2009) https://www.selfleadership.com/reflecting-and-leaning-2009- in a wheel, but as a developing individual with his own to-2010/ needs for fulfilment in the form of, for example, having Clutterbuck D & Lane G. (2004) The situational mentor: an international freedom to be creative within their work, and in receiving review of competencies and capabilities in mentoring. Gower reward rather than punishment. developments in business, Gorseinon, UK. In a paper by Lane (Lane, edited by Clutterbuck, 2004), Figure 5 encapsulates what is envisaged as Donaldson SI, Ensher EA & Grant-Vallone EJ. (2000) Longitudinal examination of mentoring relationships on organizational commitment being the course of a mentor-mentee relationship. The and citizenship behavior. J Career Dev;26:233-249. likely duration of the mentor/mentee relationship is not 14 • converse • Summer 2020
feature Egan G. (2013) The skilled helper: a problem-management and opportunity-development approach to helping. Brooks/Cole Thompson Learning, CA, USA. Frankl E. (2004) Man’s Search for Meaning. Random House Group, UK. (First published in 1946.) Grant AM & Stober D. (2006) In: Evidence based coaching handbook. Grant AM, Stober D (Ed.) John Wiley & Son, Inc, Hoboken, New Jersey. Klasen N & Clutterbuck D. (2002) Implementing mentoring schemes: a practical guide to successful programs. Butterworth-Heinemann, Oxford, UK. Kolb DA. (1984). Experiential Learning: experience as the source of learning and development. Prentice Hall, Englewood Cliffs, NJ, USA. Maslow AH. (1971) The farther reaches of Human Nature. Penguin/ Arkana, NY, USA. Maslow AH. (1987) Motivation and personality (3rd ed.). Pearson Education, Delhi, India. Maslow AH. (1943) A theory of human motivation. Psychol Rev 50 (4): 370–96. Tay L & Diener E. (2011) Needs and subjective well-being around the world. J Personal Soc Psychol; 101(2): 354. McGregor D. (1960) The human side of enterprise. McGraw-Hill, NY, USA. Whitmore J. (1992) Coaching for performance. Nicholas Breasley publishing, UK. Rogers CR. (1951) Client-Centered Counselling. Houghton-Mifflin, Boston, MA, USA. Williams EA. (2000) Team mentoring: New directions for research on employee development in organizations. Paper presented at the Rogers CR. (1980) A way of being. Houghton-Mifflin, Boston, MA, USA. Academy of Management Meeting, Toronto, Canada. Senge P. (1990) The fifth discipline: the art and practice of the learning Zachary LJ. (2005) Creating a mentoring culture: The organisation’s organisation. Doubleday/Currency, NY, USA. guide. Jossey-Bass, Wiley, CA, USA. COVID-19 Diagnostics COVID-19 Elisa Antibody tests EUROIMMUN Anti-SARS-CoV-2 ELISA Product Range Anti-SARS -CoV-2 ELISA (IgG; IgA) Anti-SARS -CoV-2 NCP ELISA (IgG) • Spike protein S1 domain (S1) • Only diagnostically relevant epitopes • S1 contains immunologically are used – for optimised performance in crucial Receptor binding domain comparison to full length N protein (RBD) • Highly specific due to removal of - Key Target antigen for virus unspecific epitopes neutralisation • Most immunodominant antigen of the - RBD is presented in its active state coronavirus family (inaccessible in full length S protein prior to cell contact) Product code: EI 2606-9601-2 G SEROSEP.COM • Evolutionary low protein homologies euroimmun.serosep@serosep.com within the coronavirus family Product code: EI 2606-9601 G/A Summer 2020 • converse • 15
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