2021/2022 Summer Research Program - Research Projects offered by Schools in the Faculty of Science - UQ Science Faculty
←
→
Page content transcription
If your browser does not render page correctly, please read the page content below
2021/2022 Summer Research Program Research Projects offered by Schools in the Faculty of Science School of Agriculture and Food Sciences ...................................................................................... 2 School of Biological Sciences ....................................................................................................... 16 School of Chemistry and Molecular Biosciences......................................................................... 23 School of Earth and Environmental Sciences .............................................................................. 43 School of Mathematics and Physics ............................................................................................ 48 School of Veterinary Science ....................................................................................................... 74 How to apply The UQ Summer Research Program is offered by a number of schools in the Faculty of Science during the summer vacation period (mid-November to mid-February). This document provides you with a list of available projects. 1) Browse the projects. You may select a School from the table of contents above to be taken directly to their listed research projects. 2) Contact a potential supervisor in the area of your interest, or the contact person listed, to discuss your interest to undertake their research project. Gain the research project supervisor’s tentative approval in writing and include this with your full UQ Summer Research program application. 3) Submit your application via StudentHub. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 1 of 92
School of Agriculture and Food Sciences Supervisor A/Prof Brett Ferguson Duration: 6-10 weeks Contact Email: b.ferguson1@uq.edu.au Details: Discovery and Characterisation of New Molecular Components Required for the Development and Control of Legume Nodules Nitrogen fertilizer use in agriculture is inefficient, costly and can be environmentally damaging. Legume crops represent an economically and environmentally sound alternative, as their relationship with nitrogen-fixing soil bacteria enables them to thrive in the absence of nitrogen fertilizer. The bacteria (commonly referred to as rhizobia) are housed in specialized root organs, called nodules. Identifying critical components of legume nodulation is now needed to optimise the process and improve agriculture sustainability and food security. This project aims to discover and functionally characterise novel molecular factors that act in the development and control of legume nodule numbers. Findings could enhance the current nodulation model and could help underpin future strategies to reduce the current over-reliance on nitrogen fertilizers in agriculture. Number of student places available: 2 Delivery: Projects can be onsite (e.g. laboratory and glasshouse) or online (e.g. bioinformatic approaches using existing programs to identify new genes and domains) Expected outcomes: Students will gain skills in molecular signalling and plant physiology. Knowledge pertaining to various research techniques could include aspects of the following: qRT-PCR, gene cloning, transcriptomic analysis, bioinformatics, Agrobacterium-mediated transformation, gene over-expression, gene editing (CRISPR), promoter::reporter fusions, hormone quantification, new signal discovery, etc. Suitable for: An interest in plant science would be ideal, with individual projects that can be tailored to focus on research areas such as plant physiology, molecular signalling and development (genetic transformation and genome editing such as CRISPR, and plant- microbe interactions. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 2 of 92
Supervisor Dr April Hastwell Duration: 10 weeks Contact Email: a.hastwell@uq.edu.au Details: School of Agriculture and Legume Research John Hines Building (62), Room 223A St Lucia Campus Characterisation of peptides in legume root and nodule development There are a growing number of plant peptide families, with some having pivotal roles in development including root and shoot architecture; yield; as well as abiotic and biotic responses. While such peptides have been studied in the model species, Arabidopsis, they are not well characterised in crop species such as the legume, soybean. This is of interest as soybean can undergo two key agriculturally important beneficial symbiosis that Arabidopsis cannot. Legume nodulation is particularly significant as the process results in atmospheric nitrogen utilisation, rather than needing to add synthetic nitrogen fertilisers which are harmful to the environment. The project will use a range of physiological and molecular biology techniques to explore the role of peptides in legume nodulation and root development. Outcomes will enhance the molecular signalling models in these processes and provide the student with knowledge and skills useful for further studies in related areas. Number of student places available: 1 Delivery: On-site attendance at St Lucia is required. The project can be completed via a remote working arrangement if needed due to COVID-19 restrictions. Expected outcomes: Students will gain an understanding of plant peptides and plant- microbe interactions. They may gain skills in plant molecular biology, bioinformatics, plant phenotyping and sample handling. Suitable for: Open to applications from students with a background in Plant Sciences. Students in Biochemistry and Molecular Biology; and Bioinformatics with an interest in plants are also encouraged to apply. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 3 of 92
Supervisor Prof Susanne Schmidt Duration: 10 weeks Contact Email: Susanne.Schmidt@uq.edu.au Details: Advancing nutrient stewardship and the circular nutrient economy for a world without waste and pollution Evaluating plant performance with recycled nutrients and novel fertilisers based on biodegradable biopolymers Number of student places available: 2 Delivery: With ‘business as usual’, we offer empirical research. Under COVID-19 restrictions, we offer projects based on existing data and scientific literature. Expected outcomes: Performing original research analysing experimental data and contributing to writing a scientific publication, research in lab, glasshouse or field. Gaining employability skills with teamwork, planning, conducting, analysing and communicating original research to peers, practitioners and industry partners. Suitable for: Students interested in plant and environmental sciences, but also those interested in interdisciplinary studies at the interface of engineering, economics, policy and legislation. Other important details: The projects have scope to be customised to student interests. Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 4 of 92
Supervisor Prof Susanne Schmidt Duration: 10 weeks Contact Email: Susanne.Schmidt@uq.edu.au Details: Growing clean air Modelling and optimising the use of plant-based systems for indoor air quality Number of student places available: 2 Delivery: With ‘business as usual’, we offer empirical research. Under COVID-19 restrictions, we offer projects based on existing data and scientific literature. Expected outcomes: Performing original research analysing experimental data and contributing to writing a scientific publication, research in lab, glasshouse or field. Gaining employability skills with teamwork, planning, conducting, analysing and communicating original research to peers, practitioners and industry partners. Suitable for: Students interested in plant and environmental sciences, but also those interested in interdisciplinary studies at the interface of engineering, economics, policy and legislation. Other important details: The projects have scope to be customised to student interests. Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 5 of 92
Supervisor Prof Bhagirath Chauhan Duration: 10 weeks Contact Email: b.chauhan@uq.edu.au Details: Bld 8115, Room 209, Gatton Genetic diversity in turnip weed (Rapistrum rugosum) Turnip weed is becoming a problematic weed in the eastern region of Australia. A recent road trip showed that the weed is present along roadsides throughout the Darling Down areas. This project will evaluate the genetic diversity in this weed species. Genetic diversity is important for understanding the ability of weeds to adapt to different environments and the impact of herbicide selection on weed populations. DNA will be extracted from seeds or leaf tissues. The samples will be sent to AGRF for sequencing and results will be analysed by the student. The objective of the project is to characterize genetic variation in turnip weed biotypes collected from different maternal environments of Queensland. Number of student places available: 2 Delivery: The Scholar will be required on-site at Gatton for the project. Expected outcomes: Scholars will gain experience in data collection and analysis. They will also gain skills in laboratory techniques. Suitable for: This project is open to students with a background in molecular biology (DNA extraction, PCR functions, etc.). Other important details: Interested students must contact the supervisor (b.chauhan@uq.edu.au) prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 6 of 92
Supervisor Prof Bhagirath Chauhan Duration: 10 weeks Contact Email: b.chauhan@uq.edu.au Details: Bld 8115, Room 209, Gatton Mapping and estimating weeds in chickpea Drones have emerged as an innovative technology to provide spatio-temporal information about weed species in crop fields. Such information is critical for any site-specific weed management program. This project will map and estimate weeds in chickpeas. Number of student places available: 3 Delivery: The Scholar will be required on-site at Gatton for the project. Expected outcomes: Scholars will gain experience in mapping weeds in chickpea crops. Students will have the opportunity to write articles. Suitable for: This project is open to students with a background in computer science or engineering (need to work with drone images). Other important details: Interested students must contact the supervisor (b.chauhan@uq.edu.au) prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 7 of 92
Supervisor Dr Millicent Smith Duration: 10 weeks Contact Email: millicent.smith@uq.edu.au Details: Gaining new insight into mungbean physiology to increase yield potential and reliability Mungbean is an important cash and food crop grown in tropical and subtropical regions globally. Over the last three decades, the demand for mungbean has increased by over 60% and is now cultivated over 6 million hectares of land. Despite this increase in demand, the expansion of mungbean production is limited due to its low yield production and variability. A major reason for this is due to mungbean’s indeterminate reproductive behaviour which results in staggered maturity and the crop accumulating vegetation, flowers and pod components simultaneously. This behaviour has different implications for hand and mechanical harvesting systems. Other physiological components and behaviours have yet to be completely explored in mungbean (i.e. photosynthetic capacity), offering the opportunity to be exploited for increased crop productivity. This project aims to dissect the behaviour and genetics of a diverse mungbean population and to identify potential combinations of key agronomic traits that could be deployed to generate high yielding and reliable mungbean cultivars. The student will be assisting with two glasshouse experiments being undertaken simultaneously at St Lucia. The first experiment aims to collect detailed flower and pod development measurements to gain insight into how flowering behaviour influences yield potential and reliability. The second experiment aims to take detailed fluorometer measurements to determine whether the initial slope of the light response curve can be used to predict the maximum photosynthesis capacity of mungbean, which has yet to be done in any crop. Understanding these behaviours will contribute to identifying key genes of traits that are associated with high yields. Opportunities to be involved in field work at Gatton campus are also available to interested students. Number of student places available: 1 Delivery: The project duration is 10 weeks, with hours of engagement being between 25-36 hours per week. During these 10 weeks the applicant will be required to undertake the project on-site at the University of Queensland’s St Lucia campus. Expected outcomes: The student will gain an understanding of plant phenology and physiology, as well as the process of organising and managing glasshouse research experiments. They will gain skills in a range of data collection methods and will be able to undertake basic data analysis using the statistical program, R. The student will gain confidence with conducting glasshouse research activities and operating in a research environment. The scholar’s work has the potential to be incorporated into two manuscripts for peer- reviewed journal publications and will be a co-author on the paper/s. A short presentation will be required at the end of the project detailing their experience and their findings. Suitable for: This project is open to applicants from students with a science background. Students with some knowledge/interest in plant science are recommended for this project. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 8 of 92
Supervisor Dr Alexandra Langford & Dr Scott Waldron Duration: 10 weeks Contact Email: Zannie.langford@uq.edu.au Details: scott.waldron@uq.edu.au Improving rural seaweed farming livelihoods in Indonesia through improved drying oven designs In this project you will work with researchers involved with the Partnership for Australia- Indonesia Research (https://pair.australiaindonesiacentre.org/) on a project to improve the livelihoods of seaweed farmers in South Sulawesi, Indonesia. Background The Indonesian seaweed industry has rapidly expanded over the last twenty years and now supports the livelihoods of over 35,000 coastal households in South Sulawesi. The Government of Indonesia has prioritized the development of the seaweed industry as a result of its important role in poverty reduction in coastal communities. However, the industry suffers from a range of issues in production and processing. At the farmer level, seaweed farmers face challenges drying their seaweed. Substantial quality issues are introduced by poor drying practices, including drying on the ground (which can contaminate the seaweed with sand and other debris), high sun drying temperatures (which can destroy bioactive compounds), and insufficient drying resulting in high moisture contents. Farmers indicate that seaweed drying is one of the major challenges they face, particularly during the monsoon season, and as such there is an opportunity for technical interventions in this area to improve the efficiency of the industry and support more resilient and sustainable farmer livelihoods. Aim & Method This activity would investigate technologies for the development of a low temperature solar dryer for use in Indonesia to accelerate drying and improve seaweed quality through fast, low temperature drying. In this project, you will: 1. Review academic and grey literature on drying technologies and prepare a report on the options available and their advantages and disadvantages. 2. Design a simple survey for our local partners to distribute to seaweed farmers to understand their needs from drying technologies. 3. Report on the findings of the two activities above and make suggestions for appropriate technology interventions. There may be an opportunity to publish the findings as a journal article depending on the outputs produced. Number of student places available: 2 Delivery: Remote work arrangements available Expected outcomes: This project will provide experience analysing technical interventions for practical rural development applications, as well as in liaising (virtually) with local partners and developing a simple survey to assess seaweed farmer needs. A report based on the findings will be prepared and depending on the outputs produced, there may be an opportunity to co-author an academic article. Suitable for: This project is suitable for students with technical skills that would enable them to evaluate oven drying technologies. This could include students studying agribusiness, agricultural science, chemistry, chemical engineering, mechanical engineering or a related discipline. Students must have a technical background that enables them to review and Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 9 of 92
analyse scientific articles. Desirable qualities include an interest in and knowledge of rural agricultural development issues. Other important details: Please contact Zannie Langford (zannie.langford@uq.edu.au) to discuss this role. Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 10 of 92
Supervisor Dr Vivi Arief Duration: 10 weeks Contact Email: v.arief1@uq.edu.au Details: Effects of high temperature on growth and development of mungbean varieties High temperature stress on crop production is a global challenge. It is expected to become more frequent under future climate change. This predicted increase in temperature can have negative impact on growth and development and could decline in crop productivity. In this study, the responses to increased temperature on phenology, phenology and genetics will be quantified on selected mungbean varieties. Number of student places available: 1 Delivery: The scholar will be required on-site at Gatton twice a week for 4 -5 weeks for data collection. Once the data has been collected, student can work form either St Lucia campus or Gatton campus or remote working arrangement can also be done, if required. Expected outcomes: Scholar may gain skill in physiology, agronomy and genetics. They will have an opportunity to generate publications from this research at the end of their project. Scholar may also be asked to produce a report or oral presentation at the end of their project. Suitable for: This project is open to applications from 2nd and 3rd year students with a background in crop physiology and agronomy. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 11 of 92
Supervisor Mr Suresh Krishnasamy Duration: 6-10 weeks Contact Email: suresh.krishnasamy@uq.edu.au Details: School of Agriculture and Food Sciences Gatton Campus Building 8117A - Room 314 Systematic Review of Agriculture Education Teaching Practices Background: Teaching and learning is a key pillar at SAFS. With technology ever improving and knowledge in the field ever growing, we need to look constantly innovate our approaches to teaching to maintain our high standards by providing students with an evidence-based quality learning experience. Aim: The aim of the project is to conduct a systematic review of the literature to understand best practices around teaching and learning in agricultural education. Number of student places available: 2 Delivery: The project will be for up to 10 weeks and the scholar will be required on-site at Gatton for up to 4 weeks during the project. Most of the work on the project can be done off-campus with different phases of the project requiring on-site attendance. Expected outcomes: Scholars will be involved in a systematic review exercise which is a fundamental skill in research. Scholars will get skills in how to perform literature searches, use research tools such as endnote and how to perform review of searched literature. Scholars will be expected to produce a study report. The scholar’s work will also be incorporated into a manuscript for peer-reviewed journal publication. Suitable for: This project is open to applications from students who have an interest in research. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 12 of 92
Supervisor Mr Suresh Krishnasamy Duration: 6-10 weeks Contact Email: suresh.krishnasamy@uq.edu.au Details: School of Agriculture and Food Sciences Gatton Campus Building 8117A - Room 314 Biology Bridge Background: 1st year students taking biology have provided feedback regarding their experiences. Students who did not undertake high school biology reflected that they faced a challenge getting themselves up to speed and found themselves behind early on. However, who had prior knowledge of biology from high school found early course material at university repetitive from their high school experience and as a result felt disengaged. Aim: The aim of the project is to develop biology lesson modules that will be taken by future SAFS students who do not have prior experience in high school biology. Approach: The project will begin with a curriculum mapping exercise to map concepts covered in high school biology and year 1 biology courses at SAFS. This will be followed by the development of lesson packages and self-assessment activities. The final phase of the project will involve the deployment of the lesson packages and further study into its impact. Number of student places available: 2 Delivery: The project will be for up to 10 weeks and the scholar will be required on-site at Gatton for up to 5 weeks during the project. Most of the work on the project can be done off-campus with different phases of the project requiring on-site attendance. Expected outcomes: Scholars will be involved in a curriculum mapping exercise and will gain skills in developing study materials (e.g., questionnaires, assessment questions), research methods as well as data collection and analysis. Scholars will be expected to produce a study report and develop a lesson bank including assessment exercises which will be used by future incoming students at SAFS. The scholar’s work will also be incorporated into a manuscript for peer-reviewed journal publication. Suitable for: This project is open to applications from students who have a background in high school biology and are interested in educational research. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 13 of 92
Supervisor Dr Ammar Abdul Aziz Duration: 10 weeks Contact Email: a.abdulaziz@uq.edu.au Details: Room 235, Building 8117A Gatton campus Analysing the dynamics of rubber, maize or rice farming in southeast Asia using freely available satellite imagery (The crop will be determined in a discussion with the scholars) Our tiny research group at SAFS are working on a range of agribusiness research projects that involve modelling value chains and using remote sensing to analyse a range of aspects of agricultural activities. This project will involve conducting a systematic literature review (https://www.griffith.edu.au/griffith-sciences/school-environment- science/research/systematic-quantitative-literature-review) and the collection, processing and where possible the analysis of satellite imageries. Number of student places available: 2 Delivery: The project can be conducted fully via a remote working arrangement. However, if condition permits, in person meetings would be conducted if required. Scholars will also need to attend the weekly research group zoom meeting. Expected outcomes: Scholars will develop their critical thinking skills through the systematic literature review exercise. They will gain skills in collection, processing and analysing freely available satellite images. Scholars will also have the opportunity to network with a group of PhD students working on a range of agribusiness topics. Scholars may have the opportunity to be involved in generating publications from their research which will be a component of something larger. Scholars may also be asked to produce an oral presentation at the end of their project. Suitable for: This project is suitable for undergrads in their final year or masters students. They will need to be curious and have a passion for learning something new. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 14 of 92
Supervisor Dr Stephen Harper, Mr Johannes Biala, & Dr Duration: 10 weeks Alwyn Williams Contact Dr Stephen Harper, s.harper1@uq.edu.au, Room 105, Bldg 8150, Gatton Details: campus Mr Johannes Biala, j.biala@uq.edu.au, Mob 0409062613 Dr Alwyn Williams, alwyn.williams@uq.edu.au, Tel 54601 617 Characterization of high and low molecular weight humic substances from a range of organic materials at varying stages of decomposition The student will determine humic substance quantity and quality from various organic material sources at varying stages of decomposition through acid/alkali extraction. The data will be collated and analysed for the development of a humic index. Number of student places available: 1 Delivery: The student will be required onsite at Gatton campus for most of the project duration. Expected outcomes: The student will be involved with organic chemistry within a field and laboratory setting, collecting samples and undertaking sample analysis to produce data for the development of a humic index and compost maturity calibration. The student will be asked to produce a report at the end of the project, which may result in the opportunity to publish the obtained results. Suitable for: This project is open to 3rd year Agricultural Science students. It is advantageous if the student has extensive laboratory experience and has worked within the realm of organic matter degradation / use of organic soil amendments / recycling of organic residues. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 15 of 92
School of Biological Sciences Supervisor Dr Karen Cheney Duration: 8 weeks Contact Email: k.cheney@uq.edu.au Details: Office: Goddard Building 118 Colour perception in coral reef fishes Colour vision is essential for many animals to find food and mates, and avoid predation. However, the visual systems of most animals differ from that of humans. We therefore use visual modelling and behavioural experiments to understand how animals perceive objects in their environment. You will be trained in running behavioural experiments with coral reef fish to understand how fish perceive colour patterns. Number of student places available: 2 Delivery: The Scholars will be required on-site at St Lucia for the project. Expected outcomes: The scholar will run behavioural experiment with coral reef fish and will gain experience in experimental design, data collection, visual modelling, spectrophotometry and animal husbandry. Previous scholars have had the opportunity to co-author a publication from summer research projects. Suitable for: This project is open to applications from students with interests in neurobiology, marine science, visual ecology, animal behaviour and/or fish biology. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 16 of 92
Supervisor A/Prof Paul Ebert Duration: 8 weeks Contact Email: p.ebert@uq.edu.au Details: 3365 2973 (work) Goddard room 374 Worms on drugs Psychoactive drugs have effects on the genetic model organism, C. elegans, that reflect their effects on humans. This makes it possible to identify the genes that mediate the activity of the drugs. The specific drugs and genes that will be investigated will depend on the state of suitable projects when summer arrives, but could include fear, the reward pathway or the attention deficit drugs, amphetamine and methylphenidate. Number of student places available: 2 Delivery: The Scholars will be required on-site at St Lucia for the project. Expected outcomes: This project will combine analysis of mutants and drugs using automated behavioural assays. When applied to a tiny, reproductively prolific, rapidly maturing organism like C. elegans, it is possible to generate a large number of robust behavioural assays over the span of the summer project. Data analysis and interpretation of results will be a significant component of the project. You will be working under the direct guidance of a postdoc as well as Honours and PhD students. You will be assisting with large scale screens that will help them to determine the most productive directions for their research. Students will be expected to maintain a research notebook, keep accurate records, process data into well-annotated graphs and present results at group meetings. In essence, you will be a full member of the research team Suitable for: 3rd level coursework experience with either genetics or neurobiology. Research lab experience will be beneficial. Students who have completed BIOL3222 or BIOL3380 are strongly encouraged to apply. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 17 of 92
Supervisor A/Prof Jan Engelstaedter Duration: 8 weeks Contact Email: j.engelstaedter@uq.edu.au Details: The mutational spectrum of antibiotic resistance Antibiotic resistance is a major problem in medicine and public health. Bacteria can become resistant through single mutations in genes whose products are targeted by the antibiotic. These mutations may differ in the rate at which they arise, the strength of resistance they confer, and their fitness consequences in the absence of drugs. In this project, the students will aim to characterise the complete mutational spectrum of antibiotic resistance to two important drugs, rifampicin and streptomycin, using the model organism Acinetobacter baylyi. Specifically, this will involve screening for resistant mutants, characterising these mutants at the genetic level by DNA sequencing, and characterising them phenotypically by measuring their fitness in presence and absence of drugs. Number of student places available: 2 Delivery: Students will work in the lab for most of the time Expected outcomes: Students will gain experience in bacterial mutant screens, fitness assays, DNA extraction, PCR, electrophoresis, DNA sequencing, and bioinformatics. Suitable for: Open to all students with experience in handling of bacteria (sterile techniques) and a background in genetics (ideally BIOL1020 + BIOL2202) Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 18 of 92
Supervisor Dr Simon Hart Duration: 10 weeks Contact Email: s.hart@uq.edu.au Details: Office: Goddard Building (08), Room 220 Effects of intraspecific variation and/or phenotypic plasticity on population persistence in response to extreme weather events Climate change is causing extreme weather events to become more frequent and intense. Because these events directly threaten species’ persistence, understanding the mechanisms by which species will respond is critical. Genetic variation within species and phenotypic plasticity allow species to respond to changes in environmental conditions and so may buffer the effects of extreme weather. The magnitude of these effects is, however, unknown. The aim of this project is to quantify the capacity of genetic variation and phenotypic plasticity on the persistence of freshwater plants subject to extreme weather. Findings will improve our ability to manage the capacity of species to respond to climate change and other rapidly developing threats. Number of student places available: 2 Delivery: Attendance at UQ St Lucia campus is required Expected outcomes: Scholars will learn how to plan and run experiments in the laboratory and field, and to statistically analyse experimental data. I am optimistic that with good progress, this work will result in a peer-reviewed scientific publication, which is extremely important for career progress in science. Suitable for: Any student with an interest in how the natural world will respond to climate change. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 19 of 92
Supervisor Dr Simon Hart Duration: 10 weeks Contact Email: s.hart@uq.edu.au Details: Office: Goddard Building (08), Room 220 Effects of intraspecific variation on tipping points in ecological systems When under pressure, ecological systems can cross thresholds that can lead to large and irreversible changes in ecosystem states. These changes are associated with dramatic declines in the population densities of some species and large changes in the structure and function of ecosystems. Thus, it is critically important to quantify the vulnerability of ecological systems to thresholds, to predict when thresholds will be crossed, and to understand if state changes can be reversed. This project will explore how genetic variation within populations affects tipping point behaviour in ecological systems. The project will require some background in mathematics and computer simulations. We can also discuss opportunities to do some experimental work in the laboratory. Do not be intimidated by the requirements of the project. If you are interested in the project, best to just talk to me about what is involved. This project will be done in collaboration with Dr Vasilis Dakos (https://www.vasilisdakos.info/) who is at the University of Montpellier and the CNRS (French National Centre for Scientific Research) in France Number of student places available: 1 Delivery: Project can be completed through remote working arrangement if necessary. Expected outcomes: Scholars will learn about tipping points in ecological systems, and how to apply mathematical and computational techniques to explore how genetic variation affects tipping point behaviour. This is an extremely ‘hot’ and important topic in global change biology. Scholars will also have an opportunity to collaborate with world class researchers in Paris, France on ecosystem resilience. We are optimistic that with good progress, this work will result in an important peer- reviewed scientific publication, which is extremely important for career progress in science. Suitable for: Ideally, Scholars will have some background in mathematics and/or computing. However, there may be options for modifying the project according to your skills and interests, so if you are interested in the project, please talk to me about your interests and background. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 20 of 92
Supervisor Dr Andrew Letten Duration: 8 weeks Contact Email: a.letten@uq.edu.au Details: Goddard (08), Room 242 The effect of nutrient availability on the competitive hierarchy in fly gut bacteria The flow of nutrients through ecological systems fluctuates through time and yet the impact this variability has on the maintenance of biodiversity is poorly understood. The animal gut is one system where a predictive understanding of community dynamics holds significant appeal and where the resident microbiota experience significant fluctuations in resources. Numerous studies have shown that diet is a strong predictor of gut microbiome composition, with a switch in food type shifting the community structure in just a few hours. Much less is known, however, about the effects of frequency and amplitude of food intake on the gut microbiome. This knowledge gap is especially striking given that ecological theory predicts that temporal variation in nutrient availability (e.g., feast-famine vs. continuous intake) should strongly impact gut microbiome stability. The test-case for this project is the impact of resource fluctuations on 5 core bacteria species comprising the fruit fly (Drosophila melanogaster) gut microbiota. The fruit fly has long been a model for genetics and evolution, but it has also recently emerged as an attractive model-system for gut microbiome research. This experimental project will use mixed and monoculture microbial growth assays (in vitro; no fly work!) to investigate: trade- offs in resource usage amongst the core fly gut bacteria: and the outcomes of competition under different nutrient delivery regimes. Number of student places available: 2 Delivery: Onsite attendance is required Expected outcomes: Develop expertise in bacterial culture, competition assays, optical density measurements etc. Also potential for more emphasis on modelling or analysis depending on student interests. Suitable for: Students with some exposure to bacterial culture and wet lab techniques or eagerness to learn! R skills also helpful but not required. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 21 of 92
Supervisor Prof Cynthia Riginos Duration: 6-10 weeks Contact Email: c.riginos@uq.edu.au Details: Using environmental DNA to measure the biodiversity in Moreton Bay habitats Quandamooka Sea Country (Moreton Bay) sits adjacent to Brisbane and is heavily impacted by urbanisation and climate change. At the same time, the Bay is a region of notable biodiversity with many distinct habitats including coral reefs. Student scholars will contribute to an ongoing project that is using environmental DNA to characterise biological diversity in the Bay by habitats, space, and time. Number of student places available: 2 Delivery: The Scholars will be required on-site at St Lucia for the project. Expected outcomes: Scholars will learn basic molecular skills and to prepare metabarcoding libraries. Depending on interest, scholars may also learn to undertake bioinformatics and analyses of the resultant data. These data will eventually lead to peer reviewed publications and may support a UNESCO submission by the Quandamooka traditional owners for World Heritage listing. Scholars may also be asked to produce a report or oral presentation at the end of their project. Suitable for: This project is suitable for highly motivated students with demonstrated attention to detail and enthusiasm for marine biodiversity. A background in ecology and/or marine science would be most appropriate for this project. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. (Please use email: c.riginos@uq.edu.au). The projects are only feasible if access to campus and laboratories is not restricted. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 22 of 92
School of Chemistry and Molecular Biosciences Supervisor Prof Avril Robertson & Dr Kylie Agnew-Francis Duration: 10 weeks Contact Email: a.robertson3@uq.edu.au Details: k.agnewfrancis@uq.edu.au Antifungals targeting Cryptococcus Neoformans Infections caused by yeasts (Candida and Crytpococcus) and moulds (Aspergillus) are an increasing problem in healthcare with a global mortality rate of around 1.4 million, similar to tuberculosis and exceeding breast cancer or malaria. One of the most alarming and immediate threats is from the recently identified superbug, Candida Auris. Invasive C. auris causes blood-stream and wound infections with mortality rate of > 30%. C. auris is commonly mis-identified and frequently resistant to all major classes of antifungal drug. We have developed novel molecules with activity against deadly pathogenic fungi. We now have a unique opportunity to further our discovery through fully elucidating the mode(s) of action and developing an understanding of the antifungal structure-activity and structure- toxicity relationships of the series. Given the paucity of current antifungal drugs, and the severity of mycotic infections, new treatments are desperately needed. Number of student places available: 1 Delivery: On-site attendance is required at the St Lucia campus (entirely laboratory based) Expected outcomes: The applicant will learn solution and solid phase synthesis techniques, purification and characterisation methods. If synthesis is successfully completed the molecules will be tested for antifungal activity. Suitable for: This project is open to applications from UQ enrolled students only with a background and interest in drug discovery. Synthetic organic chemistry skills are required, the applicant must have completed CHEM2054 as a minimum. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 23 of 92
Supervisor Prof Avril Robertson & Dr Kylie Agnew-Francis Duration: 10 weeks Contact Email: a.robertson3@uq.edu.au Details: k.agnewfrancis@uq.edu.au Novel Anti-inflammatory compounds targeting the innate immune system Inflammasomes are part of the innate immune system responsible for processing and subsequent release of the potent pyrogenic cytokines, interleukin 1β and interleukin 18. Inhibiting inflammasomes (such as NLRP3, AIM2, NLRC4) using small molecules is an exciting strategy for future treatment of inflammatory diseases including asthma, type 2 diabetes and also disorders of the brain such as Parkinson’s and Alzheimer’s diseases. In the Robertson group, there is more than one compound series and innate immune target under investigation in this area. Number of student places available: 1 Delivery: On-site attendance is required at the St Lucia campus (entirely laboratory based) Expected outcomes: The student will learn and develop synthetic, purification and analytical skills contributing to our series for future patent and/or publication. Suitable for: This project is open to applications from UQ enrolled students only with a background and interest in drug discovery/organic chemistry. Must have completed CHEM2054 as a minimum. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 24 of 92
Supervisor A/Prof Elizabeth Krenske Duration: 6-10 weeks Contact Email: e.krenske@uq.edu.au Details: Computer simulations of (bio)molecular reactivity Our laboratory uses computer simulations to study how molecules react. By performing quantum chemical modelling we are able to explore the factors that control chemical behaviour, visualising molecules in atomic-level detail. A range of project topics are available, e.g. studying the behaviour of catalysts that degrade plastics, or studying how drug candidates bind to biological molecules leading to desirable or undesirable effects. Number of student places available: 2 Delivery: On-site attendance is required, unless prevented by COVID-19 restrictions. If necessary, the project can be converted into a remote working arrangement, but this may involve a reduction in hours and/or change of project scope. Expected outcomes: Scholars may gain skills in molecular modelling and in understanding reaction mechanisms. Scholars may learn the activities of the broader research group (e.g. by participating in group meetings and activities) and will be asked to produce a short written report at the end of their project. Suitable for: This project is open to applications from UQ enrolled students majoring in Chemistry who have taken (or are currently taking) CHEM3011. Current or previous enrolment in CHEM3001 and/or CHEM3020 is also advantageous. Other important details: Interested students must contact the supervisor (by email at e.krenske@uq.edu.au), prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 25 of 92
Supervisor Prof Bostjan Kobe Duration: 6-10 weeks Contact Email: b.kobe@uq.edu.au Details: Structural studies of proteins involved in infection and immunity The aim of this project is to use structural biology to understand the molecular basis of processes involved in infection and immunity. The work has implications for treating a range of infectious and inflammatory diseases and cancer, or for minimizing plant disease. We are focusing in particular on the proteins involved in cytoplasmic signalling by Toll-like receptors, bacterial pathogenesis, and effector-triggered immunity by plants. The main techniques will involve protein expression, purification, crystallization and structure determination, molecular interaction analyses and characterization of functional effects of site-directed mutants. Number of student places available: 2 Delivery: Physical attendance at the lab is required Expected outcomes: Scholars will gain skills in various lab techniques mentioned above and have an opportunity to contribute to publications from their research. Students may also be asked to produce a report or oral presentation at the end of their project. Suitable for: Students with background in biochemistry, biophysics and other relevant areas is an advantage. We are looking for motivated students with interest in research in the areas the lab works in. Other important details: Interested students must contact the supervisor (b.kobe@uq.edu.au), prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 26 of 92
Supervisor A/Prof Shih-Chun (Lawrence) Lo Duration: 8 weeks Contact Email: s.lo@uq.edu.au Details: Highly luminescent organic materials for Augmented Realities The project aims to develop highly luminescent organic chromophores that can be used for organic electronic devices such as organic light-emitting diodes (OLEDs for next-generation displays and lightings or augmented realities), and organic lasers. Compared to inorganic semiconductor counterparts, organic semiconductor materials offer many key advantages such as more light-weight, highly tunable, relatively cheaper and easier in materials synthesis and fabrication. The interests and demands on highly luminescent organic chromophores have been increasing in particular for bio-applications (such as bio-imaging, sensing) or organic electronics. It is challenging to generate organic chromophores with strongly luminescent in both solution and solid state, and simultaneously exhibit appropriate energy levels for charges injection in devices. The project will develop new organic semiconductor chromophores and study their properties for the potential in next- generation organic electronics including augmented realities or organic laser. Number of student places available: 2 Delivery: Laboratory attendance is required. Alternative arrangement might be needed to adapt to COVID-19 lockdown, if any. Expected outcomes: Students are expected to learn how to design, synthesis, purify and characterise organic materials, as well as the working principles and usage in organic electronic devices. Students will also have opportunities to learn advanced photophysics and device physics through working closely with physics collaborators at QU’s School of Mathematics and Physics. Suitable for: Students have strong interest in organic material development and synthesis as well as learning how organic electronics work and play roles in our next-generation laser and augmented realities technologies. Other important details: Interested students must contact the supervisor (s.lo@uq.edu.au), prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 27 of 92
Supervisor Prof Jack Clegg Duration: 6-10 weeks Contact Email: j.clegg@uq.edu.au Details: New components for the synthesis of metal-organic frameworks Metal-Organic Frameworks are a class of polymeric material formed from organic and metallic components. This project explores new ways to form these materials following an innovative hierarchical self-assembly methodology. Number of student places available: 2 Delivery: On-site attendance is required. Expected outcomes: You'll design and prepare a new organic compound, then investigate its interactions with a variety of metal ions. This project requires some synthetic laboratory work. Suitable for: Students who have completed CHEM2054 as a minimum. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 28 of 92
Supervisor Prof Bernie Carroll Duration: 6 weeks Contact Email: b.carroll@uq.edu.au Details: Mechanism of RNA interference (RNAi) and epigenetics in plants Gene silencing is a highly conserved process in plants and animals. It is of fundamental importance to gene regulation, virus protection, genome response to environment, and genome evolution. Remarkably, when silencing is triggered against a virus or an abundantly expressed gene in plants, it can spread throughout the organism. Application of exogenous RNA can also induce systemic virus resistance and gene silencing in plants. The aim of this project is to identify genetic mechanisms controlling systemic gene silencing induced by exogenous application of RNA in plants. The long term aim of the research is to use topical application of RNA to provide resistance against viruses and other plant pathogens, and to manipulate crop traits in “real-time” in the field to optimize adaptation to changing local climate conditions and harvest time for market opportunities. Number of student places available: 2 Delivery: Applicants will be required on-site for most of the project. Expected outcomes: Applicants can expect to gain experience and knowledge in PCR-based genotyping of plants for mutations in genes involved in RNAi and epigenetics, crossing and grafting Arabidopsis plants, genetic mapping, screening for reporter gene expression, and/or collection and analysis of data. Students may also be asked to produce a report or oral presentation at the end of their project. Suitable for: This project is open to applications from students with a strong interest in molecular genetics, genetic and epigenetic mechanisms, year 3 undergraduate and postgraduate students. Other important details: Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Students are also welcome to contact the supervisor if they are interested in a related project area. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 29 of 92
Supervisor Prof Elizabeth Gillam Duration: 8 weeks Contact Email: e.gillam@uq.edu.au Details: Engineering P450 enzymes for a sustainable source of plant hormones to improve food security across the world Strigolactones (SLs) are plant hormones that control many traits important for agriculture, such as shoot and root architecture, nutrient uptake and beneficial interactions with soil fungi that enhance plant viability. However they have also been exploited by parasitic weeds, for which they act as a germination signal. Parasitic weeds are widespread in arable lands of many developing countries and have devastating impacts on food production. The seeds of parasitic plants germinate when they detect SLs in the soil as this indicates the proximity of a host plant root which they can then invade. Application of synthetic SLs to infested soils would provide a way to clear arable land of parasitic weeds and greatly enhance food security in the third world. Biotechnological sources of natural or chemically modified SLs would also improve agricultural crop yield, especially from poor soils, and reduce manual labour costs in horticultural industries. The overall objective of this project is to develop microbial biofactories for SL production and to engineer ‘designer’ SLs that have specific functions by manipulating the cytochrome P450 enzymes catalysing SL biosynthesis. We will do so by analysing the evolution of naturally occurring SL-synthesising enzymes and leveraging ancestral sequence reconstruction to engineer robust novel 'designer' enzymes with specific desired activities. The vacation project would involve: (i) performing an ancestral sequence reconstruction on two P450 families involved in SL biosynthesis (this part could be done by working at home); (ii) expressing a number of extant and ancestral SL-producing P450 enzymes in E. coli for further characterisation subsequently (laboratory based experiments). Number of student places available: 1 Delivery: Applicants will be required to be on-campus for the laboratory-based aspects of the project. However, in the event of an unexpected lockdown, at least part of the project can be done online. Expected outcomes: Students will acquire skills in molecular cloning, bacterial expression and characterisation of enzymes using specialised spectrophotometric methods, and high- performance liquid chromatography. They will also acquire skills in bioinformatics, especially analysing evolutionary relationships between proteins and in sequence curation, alignment and interpretation. Suitable for: This project would suit students with strong results in biochemistry, chemistry, plant biology or bioinformatics and an interest in enzymes and their evolution. Other important details: Please send Prof. Elizabeth Gillam your CV, academic record and a brief cover email explaining why you would like to do this project prior to submitting an application. Interested students must contact the supervisor/s, prior to submitting an application. Evidence of supervisor support is required to be uploaded as part of the application process. Faculty of Science, Summer Research Program, Project List 2021/2022 Last updated 10 September 2021 Page 30 of 92
You can also read