2019 of Medicine Review - Find out about the new ARCH Calgary program at PLC.
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2019 Review 2018-19 ANNUAL REPORT Department of Medicine Find out about the new ARCH Calgary program at PLC. 5 PAGE
2019 Review DIVISION DEPARTMENT OF MEDICINE PROFILES UNIVERSITY OF CALGARY AND ALBERTA HEALTH SERVICES Message from Department Head 44K 2018-19 REPORT PAGE 56 Dermatology PAGE 62 Endocrinology & Metabolism PAGE 64 “We have worked hard to provide 44,069 outpatient clinical Gastroenterology & Hepatology referrals received by Central reports and information that highlight Access & Triage (CAT). PAGE 66 the Department's important clinical, PAGE General Internal Medicine 60 PAGE educational, academic, and administrative 68 activities and accomplishments in the PHYSICIAN PROFILES Geriatric Medicine Meet two members of the Department PAGE 2018-19 Fiscal Year.” of Medicine, Dr. Jane Lemaire and 70 Dr. Richard Leigh Dr. Habib Kurwa, and see how each, Hematology & Hematological Professor and Head, Department of Medicine in their own ways, are working to Malignancies PAGE improve health care for all Albertans. 72 56 PAGE PAGE 36 Infectious Diseases PAGE 74 $30M RE-THINKING HOW WE QUALITY IMPROVEMENT Nephrology PROVIDE CARE INITIATIVES PAGE Learn about several collaborative, In 2018-19, many of our Divisions 76 multidisciplinary programs that collaborated with Primary Care Respiratory Medicine $29,991,365.87 in total provide care outside of a traditional and Strategic Clinical Networks on PAGE annual research revenue, health care or hospital setting, QI initiatives. The changes made 78 tailor care to meet patients’ specific because of these initiatives have Rheumatology including $6.88 Million in needs, and meet patients ‘where allowed the Department to provide PAGE CIHR revenue and $16 Million they’re at’. better, and more timely care for 80 in clinical research revenue. PAGE all Albertans. Our Community 4 PAGE 82 PAGE PAGE 58 46 DEPARTMENT 497 INNOVATIONS IN CLINICAL RESEARCH OPERATIONS From ‘bench to bedside’: Find out Department Organization geographic PAGE The Department of Foothills Medical Centre Medicine is located in the (FMC) and UCalgary about some of our recent innova- tions in clinical research and how The Department of Medicine 86 consists of 431 primary scope Alberta Health Services – Calgary Zone and at Foothills Campus, Peter Lougheed Centre (PLC) Department of Medicine members are working to improve the health members and 66 cross- Department Demographics PAGE 87 the Cumming School of and Sunridge Landing, PARENT ORGANIZATIONS and lives of Albertans. appointed members. Medicine, University of Rockyview General Hospital The Department of Medicine exists as Awards PAGE PAGE Calgary. The Department (RGH), South Health a Department within both Alberta Health Services (AHS) and the University 24 88 PAGE 89 serves a catchment of Campus (SHC), Richmond 2.4 million residents Road Diagnostic and of Calgary (UCalgary). To reflect this Patient Data of Southern Alberta, Treatment Centre (RRDTC), unique dual-organizational structure, “Physician wellness is when you’re not PAGE both AHS’ and the UCalgary’s logos 92 Southeastern British Columbia and Southwestern Sheldon M. Chumir Health Centre, and the Associate and colour palettes are featured in just surviving in your work, but you’re Publications Saskatchewan. Department Clinic, Gulf Canada Square. balance throughout this Report. thriving in your work, so that you can be PAGE Members are located at 93 7 medical sites across at your very best and deliver excellent Revenue Calgary, including the patient care. Because that’s really what PAGE 94 our work is as physicians.” Physician List PAGE Dr. Jane Lemaire Vice Chair, Physician Wellness & Vitality 95 PAGE 40
educating the next generation Our Mandate is to identify and mentor trainees who have potential to become academic leaders in medicine and related fields: powerful One of the core tenets of the Department of Medicine and Oncology, as well as with the six Calgary identify them, mentor and support them, provide them partnerships is that collaborative, multidisciplinary teams and Area Primary Care Networks (PCNs). Our with the opportunities to be competitive for academic are essential for providing members are also exten- faculty positions, and ulti- outstanding medical care sively involved within mately recruit them as the to all Albertans. We have Alberta Health Services’ medical leaders of tomorrow. close working relationships sixteen provincial Strategic with other Departments, Clinical Networks (SCNs). including Community Health, Cardiac Sciences, 6 THINGS YOU impactful Department Members as well as within W21C, conduct world-class a research and innova- research translational and health tion initiative based in the SHOULD KNOW outcomes research University of Calgary and within all seven Research Calgary Zone of Alberta Institutes at the University Health Services. ABOUT THE of Calgary’s Cumming School of Medicine DEPARTMENT OF MEDICINE innovation In collaboration and partnership with PCNs Other innovative programs we have developed include to improve and SCNs, the Department has established numerous the Geriatrics Fracture Liaison Service, COPD patient care Clinical Care Pathways and Specialist Link services, Initiative, Lung Cancer Screening Program, Home which have reduced wait Dialysis Program, Diabetes lists for specialist services in Pregnancy Clinic, Health and allowed more patients Analytics Working Group to receive quality care in (HAWG), and the Calgary the medical home. Zone Medical Services Clinical Safety Committee improving Our members are committed to improving both lead innovative clinical and research programs to (MSCSC). public Public Health for the benefit of all Albertans. Dr. John improve patient care for vulnerable populations, health Conly, who is the current Medical Director for W21C including refugees and patients with substance and former Head of the use disorders. Dr. Cheryl Department of Medicine, Barnabe, Vice Chair of conducts groundbreaking Indigenous Health in the research on antimicrobial Department of Medicine, resistance and stewardship. is helping to drive work to Dr. William Ghali is the improve health outcomes Institute Director for the O’Brien Institute for for Indigenous patients. our We are one of the largest Departments in appointments in the Department of Medicine Public Health. Drs. Gabriel Fabreau and Prabh Lail membership the Cumming School of Medicine and Calgary or Division of Cardiology (Cardiac Sciences), Zone, and have grown to and 66 members with just under 500 members cross-appointments to the in 2018-19, including 431 Department of Medicine. members with primary 2 DEPARTMENT OF MEDICINE 2018-19 ANNUAL REPORT 3
RE-THINKING HOW WE PROVIDE CARE roviding health care to Dr. Parabhdeep (Prabh) Lail THE PATIENT NEARLY DIES. He or she General Internal Medicine Specialist, is admitted to hospital with complica- Medical Director, Addiction Recovery and Community Health (ARCH) Calgary tions from liver disease. They have thousands of Calgarians is a gastrointestinal bleeding with massive varices—veins that are enlarged and ADDICTION swollen. The patient is resuscitated, huge and complex undertaking. RECOVERY AND the varices are banded and appropriate medication is administered. COMMUNITY When the clinician digs deeper The Department of Medicine, AHS, and HEALTH (ARCH) to explore the cause of the liver disease, they may find the patient has longstanding alcohol use disorder. CONTRIBUTORS Dr. Parabdheep (Prabh) Lail UCalgary are constantly working together AT PLC Delivering front-line acute care In that case, the doctor will likely tell the patient to stop drinking or face certain death. But Dr. Prabh Lail to find ways to improve how to provide Dr. Karmon Helmle Dr. Julie McKeen says the patient needs more than a is demanding work, and it’s Dr. Michelle Grinman directive, they need counselling and Olive Wiley an extra challenge to provide information on treatment options in (patient) Winnie Smith (patient) better care. support for the many patients who suffer from addictions. Now, a special team at the order to stop drinking. That’s where the new Addiction Recovery and Community Health DIVISION INVOLVEMENT Peter Lougheed Center is (ARCH) consultation service comes in. Endocrinology & Metabolism In some cases, change starts when one individual person And you’ll read about a program that serves to bridge “Often the reason for admission or helping give wraparound care General Internal who is paying close attention notices a gap in care for their acute care hospitals with people in the community who need a hospital visit is a consequence of or Medicine to patients with addictions. directly because of a substance use patients. In this chapter you will read about how a resident in lower acuity care, by bringing hospital-quality care home. the Department started asking questions that led, eventually, We are dedicated to providing health care that supports disorder. There has been very little being to scores of people from the Department, AHS and UCalgary the entire person—not just a single illness or condition. offered in acute care for these patients, working together to close that gap and dramatically improve To ensure we do this we work collaboratively; bringing so there certainly was a gap,” says care for people with diabetes who are admitted to hospital. different disciplines and partners together to develop new Lail, the medical director of the ARCH Sometimes we start to re-think the way we’ve always programs that provide better care in the hospital and program at Calgary’s Peter Lougheed done things when we see colleagues outside our jurisdiction beyond into the community. Centre, a specialist in substance making changes and improving care by finding new ways to use disorders and a former Canada tackle old problems. In this chapter we also bring you a story Addiction Medicine Research Fellow. about a new team that’s emulating a program that began in Edmonton to provide wraparound care to people with addictions who are admitted to the Peter Lougheed Centre. 4 DEPARTMENT OF MEDICINE 2018-19 ANNUAL REPORT 5
“In terms of emergency room visits, one-third of patients—if not more— have some sort of substance use disorder.” Dr. Prabh Lail ARCH has operated at the Royal harm reduction and creating efficien- workers, especially in cases where a PREVIOUS PAGE Peer Support Worker Alexandra Hospital in Edmonton since cies in the system by improving health patient’s immediate needs are housing Catherine MacAllister 2014 as part of the Inner City Health outcomes and health care access. and food. Many patients don’t even takes Kari High, a and Wellness Program. It launched in “Addiction is a disease that doesn’t dis- have photo identification. patient in the ARCH Calgary in November 2018 and has a criminate,” says Lail. “Anyone from any Lail says many of her colleagues are Calgary program, team of 12 physicians on rotation, two socio-economic background can have eager to learn more about ARCH while outside for a coffee and conversation in the social workers, two addictions coun- a substance use disorder and they can others may be critical of the service sunshine – part of the sellors, two peer support workers, an end up being very vulnerable.” ARCH and its patients. “We try to have open “full wrap-around care” outreach worker, a nurse practitioner, patients may also be socially vulnera- and honest conversations, no matter that ARCH provides. a registered nurse, a clinical nurse ble; many are homeless. how difficult they are, with the goal of PAGE 6 educator, an administrative assistant, ARCH provides what Lail calls educating and working towards a culture Top left: and a pharmacist. “full wrap-around care.” It starts with change that needs to happen in acute Dr. Prabh Lail, the Demand for the ARCH’s services ensuring basic patient needs are met: care.” Lail and her team are working on Medical Director for the has been steady. “We have seen close food, clothing and shelter. The next breaking down the considerable stigma ARCH Calgary program, speaks with Catherine to 1,000 patients at our site alone. It step is inquiring about housing status surrounding addictions, one patient and MacAllister. The ARCH motivates me to think that we certainly and testing for sexually transmitted one conversation at a time. Team meets for rounds need to expand this to other sites as infections, diabetes and dyslipidemia ARCH has become a vital resource every day to review well,” she says. “When we think of the (abnormal levels of lipids in the blood), in Alberta, particularly in light of the patients currently in visits to emergency rooms, on average screening for colon cancer and pap rising fentanyl crisis—front-line staff are the program. one-third of patients—maybe more— smears for women. seeing cases of opioid use disorder and Bottom left: also have addiction issues.” Intake forms are completed along related issues more frequently than ever All patients in the ARCH sees people with addictions with full assessments of substances, before. Lail is hoping to dedicate time to ARCH Program receive Naloxone Kits. These from every walk of life; focusing on primarily alcohol, tobacco, opioids, training more clinicians in addictions so kits are available free cannabis, stimulants and benzodiazap- ARCH is able to expand across Calgary of charge to anyone at ines—depressant drugs that include and help more patients once they leave risk of opioid overdose. sleeping pills and tranquilizers. This the hospital; preventing readmissions Family and friends can assessment helps the ARCH team know and medical complications. also get a kit. what they’re dealing with in terms of “The philosophy of our program intoxication and withdrawal symptoms. is to meet patients where they’re at,” Nurses initiate many of the consul- says Lail. “We don’t set the goal for tations because they’re on the front the patient. We work with patients to line and recognize when patients with set their goals and we support them substance use issues would benefit in achieving those goals.” from ARCH services. Addictions coun- sellors become involved as do social 6 DEPARTMENT OF MEDICINE 2018-19 ANNUAL REPORT 7
“Addiction “There was very is a disease little being that doesn’t offered in acute discriminate.” care for these PROVIDING SUPPORT PREVIOUS PAGE Top right: Bottom right: Drs. Prabh Lail and Kate PAGE 8 AND 9 Brad Johnson and Dr. Prabh Lail patients so there certainly Brad Morrison is one Instead, everyone who In the Emergency Colizza review the list Dr. Prabh Lail visit with of the ARCH support comes through the ARCH Department, Dr. Kate of consult requests for James Galant, another program receives wrap- Colizza, ARCH Assistant patients with substance patient who is bene- workers who meets with and helps people who have addictions around care. And the peer support workers play a pivotal role in that care; Medical Director, speaks with Brad Morrison, the program’s other use issues who would benefit from ARCH services. Many of these fitting from the ARCH Calgary program. was a gap.” Peer Support Worker, consult requests are Dr. Prabh Lail when they’re admitted acting as a trusted bridge while Kai Johnson, RN initiated by nurses in the to the Peter Lougheed between the person with prepares a Naloxone Kit. Emergency Department. Centre in Calgary. addictions and the health care professionals and Brad Morrison has a deep provide “a warm handover.” understanding of the ten or so people he meets every “He felt, day in his role as ARCH peer support worker at the PLC. for the first Morrison struggled with his time, that own addiction issues for decades and spent years somebody trying to get clean and sober. He started working with finally got ARCH when it launched in it, and that November, 2018 and so far, the program has helped he wasn’t more than 1,500 people. One of them really stands going to be out in his memory—a 60 stigmatized year old man with alcoholism who had been admitted to and sent the emergency department about 80 times in the year away without prior. “He couldn’t stop any help drinking,” says Morrison. “He would do his best. He’d or under- come to emerg, they would rehydrate him, hold him for standing.” four to six hours and then Brad Morrison discharge him.” The man would be sent on his way “Typically with the way with advice to go to detox these patients have been and quit drinking. treated, they don’t really trust When inevitably, the man the staff in any health care came back to the hospital, setting,” he says. “I reassure Morrison sat with him and the patient that we are there shared a bit about his own for them. Then I go to the story before telling him how staff and let them know what ARCH was going to help the patient’s going through, him. “He held his blanket to what their fears are and why his face and started crying. they’re here.” He felt, for the first time, Morrison sees a bit of that somebody finally got himself in every patient he it, and that he wasn’t going meets. And he’s thrilled to be stigmatized and sent he can help them. away without any help or “You know, some Sundays understanding.” I can’t wait to get here Monday morning because I love my job that much.” 8 DEPARTMENT OF MEDICINE 2018-19 ANNUAL REPORT 9
INITIAL “Residents WHAT IS BBIT? OBSERVATION BASAL INSULIN Dr. Karmon Helmle, The questions asked about knew how Basal insulin is intermediate or long acting and mimics the to best treat clinical assistant professor, the clinicians’ comfort level background insulin typically Department of Medicine, with managing patients’ produced by the pancreas in was in her first year of diabetes and whether they people without diabetes. residency in Calgary when she noticed the care given to patients with diabetes on felt they needed more training or information. The results of the diabetes in BOLUS INSULIN Bolus insulin is short or the medical teaching unit didn’t always line up with survey—“We are very com- fortable treating diabetes. hospital, but rapid acting and it balances the carbohydrates consumed in reality, the guidelines that suggest We’re very comfortable with at meals. doctors use BBIT. different insulins in different So, for her first year complex scenarios. We INSULIN CORRECTION resident’s research project, she surveyed her colleagues about diabetes management. know that we should be treating people with BBIT strategies and not using the actual treatment Insulin correction is another short-acting insulin that makes small corrections and She asked clinicians to fill out a questionnaire about sliding scale”—did not line up with what Dr. Helmle was didn’t match brings blood glucose back to target, if needed. with what how they order insulin for observing in the hospital. their patients and manage a TITRATE variety of complex scenarios. Ensure blood glucose is we knew we monitored four times daily and insulin doses are adjusted regularly to meet should Diabetes Canada targets. Dr. Helmle Dr. Karmon Helmle Clinical Assistant Professor, ONE OF FIVE adults admitted to the hospital in Alberta has diabetes. decided to dive be doing.” Department of Medicine Physician Champion, Provincial Diabetes These patients are usually admitted in further Dr. Karmon Helmle Inpatient Management Initiative, for a different medical reason but their Diabetes Obesity Nutrition Strategic diabetes creates complex issues and Clinical Network can dramatically slow their recovery. Dr. Julie McKeen Clinical Assistant Professor, People with diabetes are often Department of Medicine experts in managing their chronic 5% Physician Lead, Provincial Diabetes Inpatient condition day-to-day, but that becomes Management Initiative, Diabetes Obesity Nutrition Strategic Clinical Network difficult when they’re in the hospital and they have little control over their diet, physical activity and other factors. USING Basal bolus insulin therapy (BBIT) DIGGING KNOWLEDGE is a proactive way to give insulin that mimics the body’s natural production DEEPER TRANSLATION of the hormone. Research shows that BBIT is a better way to treat people with For her second year difficult to actually order TO IMPROVE diabetes while they’re in the hospital than using sliding scale insulin (SSI), residency research project, Dr. Helmle looked at old the sequence of insulin in Calgary’s hospital’s software INPATIENT where a patient is administered insulin DIABETES AFFECTS electronic health records system, Sunrise Clinical AN ESTIMATED 1 IN 20 depending on their blood sugar levels. to see whether the records Manager (SCM). They CANADIANS. DIABETES SSI is not individualized to the patient, can result in large blood glucose fluctu- aligned with the results from her first-year survey. needed an order set—a group of pre-packaged MANAGEMENT ations over the day which can increase morbidity, mortality and length of stay. The records supported her observation that clinicians instructions that allow clini- cians to order BBIT for their In 2007, a medical resident in The BBIT program was developed to were not, in fact, using BBIT patients in just a few clicks. Calgary started asking questions make it easier for clinicians to follow the to treat their patients with Dr. Helmle worked with a few necessary steps of ordering insulin for diabetes in hospital. colleagues in IT to develop about how people with diabetes their patients with paper order sets, or When Dr. Helmle started an order set and they saw receive care in the hospital. Those in Calgary hospitals within the Sunrise asking her colleagues an uptake in clinicians in initial questions have informed Clinical Manager (SCM) software. why they didn’t use BBIT, Calgary using BBIT. a province-wide initiative that’s they told her it was really standardizing and improving care for patients with diabetes. 10 DEPARTMENT OF MEDICINE 2018-19 ANNUAL REPORT 11
$13b “It became a PAGE 10 AND 11 Dr. Karmon Helmle and Dr. Julie McKeen question of review analytical data for the BBIT.ca and KTToolkit.ca websites. CANADA’S HEALTH CARE how to take PAGE 13 The Improved Glycemic Management core team best evidence BUDGET CONTRIBUTES meets at the Richmond $13 BILLION A YEAR Road Diagnostic and FOR 2 MILLION PEOPLE WITH DIABETES. Treatment Centre and translate it (RRDTC) to review the status of the Provincial In-Patient Diabetes Management Initiative. into practice— the knowledge translation piece.” Dr. Helmle had Dr. Julie McKeen identified a care gap for people with diabetes in hospital The DON SCN core committee identified diabetes management in hospitals as a priority for Alberta ASKING PATIENTS Meanwhile, the Diabetes, Obesity and Nutrition Strategic Clinical Network (DON SCN) did a patient survey evaluating patient DON SCN received feedback from 672 patients who have diabetes and were admitted to an Alberta hospital in 2014. Those An Improved Glycemic Management core team was assembled. And it quickly identified that about a third of patients with diabetes had 20% 4th ABOUT 20% OF ADULTS ADMITTED TO ALBERTA DIABETES IS THE FOURTH MOST COMMON HOSPITALS HAVE CO-MORBIDITY IN perceptions of diabetes patients with diabetes blood sugar levels that were DIABETES. PATIENT CHARTS. care in hospital. DON were less satisfied with well above the recommended SCN, one of 16 SCNs in their care in hospital than guidelines. Further, the team Alberta, is a network of people without the disease. found patients with diabetes health care providers, The patients with diabetes stayed in hospital about 40 patients, researchers and identified three areas of less per cent longer compared to policy makers with expertise satisfaction: blood sugar those without. The team also in specific areas. SCNs control, nutrition and finally verified, provincially, that the identify care gaps and find their relationships with their use of BBIT was low and cli- innovative ways to deliver care providers and the rela- nicians were using outdated care and provide better tionship between hospital SSI to treat their patients, outcomes for Albertans. care providers. confirming a widespread, complex problem. 12 DEPARTMENT OF MEDICINE 2018-19 ANNUAL REPORT 13
MAPPING EARLY A STRATEGY ADOPTER Moving from Implementing BBIT order sets and basic diabetes importance of hypoglycemia and its management, but best practices SITES education was only one equally important, the to common Beginning in early 2016, led the change, mindful of The DON SCN group piece of a complex puzzle to recognition and treatment ten early adopter sites the barriers at that specific facilitated baseline and practice started implementing the site and armed with specific audit data for 18 months. improve the care of patients of hyperglycemia. 450% with diabetes in hospital. Together, the transforma- knowledge translation plan tools to overcome them. The group gave the sites The team developed a tive project was called the toward changing clinical While initial education was targeted feedback, provided comprehensive strategy that Provincial In-Patient Diabetes practice from SSI to BBIT. important, tools to promote information and knowledge included nine other support- Management Initiative. The After a few months, the sites and sustain change involved translation tools to share ing initiatives, identified their overall goal was to improve gave feedback around what much more than just ongoing with frontline staff and internal AHS sponsors and glycemic management in was working well to address education. Champions helped re-evaluate barriers their barriers, and what worked to influence their set out timelines. hospital, better aligning with Revising to address any practice These other collaborative guidelines, available literature new barriers had emerged. peers and share successes drift, quickly and early. initiatives included everything and how patients are taught order The early adopter sites while on the lookout for There was consistent from developing appropriate to manage their diabetes sets when IMPLEMENTING implemented in a staggered emerging barriers. With and sustained increase PROGRAMS FOCUSED nutritional support, ways outside of hospital. needed ON TREATING fashion, with each site con- support from their admin- in ordering of BBIT which to manage patient-specific Team members identified HYPERGLYCEMIA SAW tributing to the knowledge istrators, audit data was led to improved glycemic A 450% RETURN ON dispensing of insulin as well a number of outcomes and INVESTMENT. and tools available to the collected and shared to control, decreased episodes as policies and guidelines pulled together to reach them. next site. support and sustain the of hyperglycemia and no for highlighting not only the At each of the early change from SSI to BBIT. increase in hypoglycemia. Identifying adopter sites, physician, The early adopter sites nursing, pharmacy and collaborated and solved initiatives 40% administrative champions problems together. Research begins DEVELOPING KNOWLEDGE into how other sites implemented ORDER SETS TRANSLATION BBIT When it came to developing Identifying best practice is The Improved Glycemic the order sets—the specific one thing. Having people Management team worked DON SCN IMPROVED GLYCEMIC instructions about ordering adopt them is another matter with knowledge trans- MANAGEMENT TEAM IN ALBERTA, PATIENTS BBIT for a patient—the team altogether. Even when there’s lation experts and the Dr. Julie McKeen WITH DIABETES STAY IN looked at all the order sets ample evidence and whole- Alberta SPOR Support Physician Lead HOSPITAL 40% LONGER THAN THOSE WITHOUT. Dr. Karmon Helmle available in the published hearted support for changing Unit (SUPPORT = Support Physician Champion and unpublished literature a clinical practice, the for People and Patient- Leta Philp across Canada as well as process of establishing and Oriented Research and Clinical Practice Lead IDENTIFYING hospitals and jurisdictions across the country that had sustaining the new patterns of care can be challenging. Trials) to develop a three stage knowledge transla- Glenda Moore Past Project Lead TEN EARLY ADOPTER SITES Rhonda Roedler BARRIERS already implemented order sets for BBIT. That’s where the science of knowledge translation tion plan to promote the change to BBIT. It identified Provincial Pharmacy Lead −− Chinook Regional Hospital Edwin Rogers The core team undertook The core team found Leveraging insights from comes in. It closes the gap and addressed barriers AHS, Analytics −− Canmore General a national environmental that while each site had its those that had already imple- between ‘what we know’ and offered a deliberate Naomi Popeski Hospital scan, collecting information own unique culture, many mented BBIT order sets, a and ‘what we do’—so called approach to help teams Assistant Scientific Director, DON SCN −− Oilfields General Hospital from dozens of acute care barriers and facilitators were unified provincial BBIT order ‘knowledge to action gaps’ adopt BBIT into their Gabreille Zimmerman −− Calgary Urban Hospitalist sites across Canada that shared amongst sites. The set was developed. AHS or K2A. These gaps can be daily routines. Program Coordinator, had implemented order sets Alberta team concluded Human Factors supported a responsible for variations Knowledge Translation Program at Foothills and Implementation Medical Centre, Peter for BBIT. The Alberta team that to overcome these usability assessment and the in practice and big discrep- Science, AB SPOR focused on the barriers the many shared barriers, an order set was revised where ancies in patient outcomes, Support Lougheed Centre, hospitals had encountered organized, evidence-informed needed. The SCM BBIT quality and safety of care, Rockyview General DON SCN LEADERSHIP and what helped implemen- approach was required. Order Set was updated to efficiency and cost. Petra O'Connell Hospital, and South tation of BBIT order sets align with the provincial order Senior Provincial Health Campus Director at each site. set. Once implemented, −− University of Alberta Dr. Peter Sargious feedback was sought from Senior Medical Director Hospital early adopter sites, and −− Grey Nuns Community further revisions were made. Hospital The order set is now on its −− Queen Elizabeth II sixth iteration. Hospital 14 DEPARTMENT OF MEDICINE 2018-19 ANNUAL REPORT 15
PERFORMA NCE SCORE CARD Basal B olus Ins ulin The rapy Pro The BBIT gram initiative g ets top m arks for im “This is a road inpatient d PAGE 16 iabetes m proving Dr. Karmon Helmle anageme reviews data on the Basal Bolu nt by supp s Insulin T orting map now. BBIT website with herapy ord Core Team members ering prac Gabrielle Zimmerman, GOAL tices. Edwin Rogers, and We’ve created a RESULT Leta Philp. Improve B BIT orderi in hospita ng l Overall, B BIT orderi ng process of how 2.5x from baseline Improve ra tes of to implement hyperglyc emia 15% fewe moderate r days wit or worse h this complex hyperglyc emia Adoption and contin use of BB ued practice change. IT 97% of sit es “satisfi or “very s ed” atisfied” w implemen it h tation. 95 BBIT site imple- sites repo % of rt BBIT us “frequentl e d y” or “alw after imple ays” mentation mentation BBIT orde ring adop at all AHS ted sites Of 106 ho spital site guidelines have in Alberta s , 71 have implemen ted the BB protocol, IT been created with an ad 9 sites in d itional progress and are shared on our BBIT website.” Dr. Julie McKeen 5.3% 9.6% BBIT IMPLEMENTED ACROSS THIS BBIT APPROACH REDUCED THE FREQUENCY OF HYPERGLYCEMIC THE BBIT APPROACH SAW A 9.6% REDUCTION IN LENGTH OF STAY AT ALBERTA PATIENT-DAYS BY 5.3% THE CALGARY ZONE There are 106 acute care has been developed to barriers to BBIT imple- WITHOUT INCREASING HOSPITALIST GROUP’S THE FREQUENCY OF FOUR SITES. sites in Alberta. And most help other sites provincially, mentation, and links to the HYPOGLYCEMIA. of them are either in the nationally, and internationally evidence-informed tools process of implementing move to BBIT and improve targeted to each. All BBIT order sets or have their patient care. Anyone tools have been made already done so. Well can access the “BBIT Site publicly available. beyond Alberta’s borders, Implementation Guidelines” As well as improving care other acute care sites at BBIT.ca and tailor them to for patients with diabetes in are contacting the people work in their own specific site. Alberta hospitals, the whole who were involved in the A second website, process of implementing a project to gain insights www.KTToolkit.ca, guides change in practice to BBIT to lend to their own BBIT users through the process may serve as a road map for implementation. of identifying cultural, other complex interventions A website, www.BBIT.ca, awareness and capability, in the province. containing all of the education communication, system, and implementation guidelines resource, and patient-related 16 DEPARTMENT OF MEDICINE 2018-19 ANNUAL REPORT 17
Dr. Michelle Grinman FOR 89 OF HER 90 YEARS, Olive Willey in CCH or stay as an inpatient at the PAGE 18 Medical Lead, Complex Care Hub Top Left: had never spent a night in hospital. hospital. Those who choose CCH are Division of General Internal Medicine Dr. Michelle Grinman Even after her visit to the emergency sent home where they receive daily meets with the Complex department at Rockyview General care and monitoring from a team that COMPLEX CARE Care Hub team at RGH. Hospital (RGH) last spring, she spent is overseen by a General Internist/ Bottom Left: just one day in a hospital bed thanks Hospitalist, Clinical Assistant and HUB BRINGS THE to the new Complex Care Hub Nurse Navigators. The team collabo- Dr. Michelle Grinman and Kirsten Proceviat, (CCH) program. rates with the Mobile Integrated Health HOSPITAL HOME Manager of Transition This innovative program is a Service, also known as the Community Services for Rockyview General Hospital (RGH) “virtual inpatient unit that allows Paramedics in the Calgary Zone who Patients enjoy the benefits of eligible patients to receive the same serve as the eyes and ears of the and South Health Campus (SHC). home with hospital-quality care. kind of care and treatment they would physicians in patients’ homes. Rigorous Centre: in hospital, but within the comfort of safety protocols ensure patients have Barb Leteta, Nurse their own home.” Says Dr. Michelle a direct line to their care team should Navigator, and Grinman, a General Internal Medicine questions or concerns arise while Dr. Azadeh specialist at RGH and originator of they’re at home. Tests and lab work can Motehayerarani, CCH in the Calgary Zone. be ordered with the same priority as Clinical Assistant – members of the It serves as a bridge between inpatients. The CCH Nurse Navigators Complex Care Hub acute care sites and the community, report to Transition Services and are (CCH) team – review she adds. Patients who come into the able to access home care services, a CCH patient’s chart. emergency department or who are which enables them to leverage PAGE 19 admitted to inpatient wards at RGH or existing pathways for comprehensive Drs. Grinman and South Health Campus (SHC) requiring geriatric assessments provided by the Motehayerarani see lower acuity care that would otherwise Geriatric Consult team, physiotherapy, Benjamin Predella at require hospitalization are admitted occupational therapy and social work. the Rockyview General Hospital, a patient who to the CCH program. These patients Dr. Grinman and her team have is also participating in receive daily, sometimes twice daily, also fostered relationships with Primary the Complex Care visits to manage their acute issues Care in order to enhance transitions of Hub program. as they would under a conventional care from CCH to the health home. hospital admission. But unlike tradi- The Calgary West Primary Care tional inpatients, CCH patients aren’t Network (PCN) has hired two nurses to transferred to a unit in the hospital to liaise with the CCH Nurse Navigators in recover – instead they sleep at home. order to expedite transition of patients Patients who meet the program’s back to the PCN and to support them in criteria are given a choice – participate implementing their complex care plan. 18 DEPARTMENT OF MEDICINE 2018-19 ANNUAL REPORT 19
PAGE 20 AND 21 Complex Care Hub patients, like Benjamin Predella, can also be monitored and seen by the team at either RGH or SHC when they come to either site for medical tests or procedures. The East Family Care Centre has also “You’re in your own bed, you can partnered with CCH to re-roster patients go have coffee with friends – you’re not that require home visits or intensive stuck in a hospital bed the whole time,” primary care services upon discharge say Willey. “When the doctor gave me from the program. This comprehensive the option to stay in hospital or go home, team approach not only benefits patients it was an easy decision to make.” by allowing them to recover within the Daughter Dianne Arnott says she comfort of their home, it also improves felt confident about her mom’s choice: the healthcare system through more “There were no concerns for mom’s efficient use of resources. care whatsoever. It was a logical “We know that hospital-at-home choice, really. She wasn’t sick enough services have been shown to reduce to stay in hospital, but she’s still getting visits to emergency departments and the care she needs when she needs provide flexibility during crises or surge it, whether it’s from her community situations,” says Dr. Grinman. “Older paramedic or the doctor at Rockyview. adults treated within this model are also The attention has been very fast and less likely to have functional decline thorough. We’re very impressed.” and need long-term care or assisted Winnie Smith, another patient in the living one year later. program, also shared why she made “Multiple systematic reviews and the decision to receive hospital-level meta-analyses of Hospital at Home care at home through the Complex programs around the world have shown Care Hub. “Privacy. Like having reduced morbidity and mortality when somebody else next to you moaning hospital-level care is delivered for the and crooning and everything you know. right population of patients,” she says. I [would] rather be at home where I “When a senior comes to the have peace and quiet,” says Winnie. hospital and receives meals in bed and isn’t walking around, they’re more likely to deteriorate quicker than patients being treated at home who remain active and independent.” For Willey and her family, the CCH means quality of life isn’t sacrificed for quality of care. 20 DEPARTMENT OF MEDICINE 2018-19 ANNUAL REPORT 21
PERFORMANCE SC “Privacy. Like ORECARD having somebody Complex Car e Hub Progra else next to you Data collected by m Complex Care H moaning and 17-month period ub staff over a (Feb 2018 – July crooning and the considerable 2019) confirms success of the pr everything you ogram to date: PROGRAM MEASUR know. I [would] ES RESULTS QUALITY OF PRELIMINARY “After going PAGES 22 AND 23 rather be at home CARE 96% Percentage of pa PROGRAM ANALYSIS The Complex Care tients (n=66) wh o Preliminary economic through this Hub allowed Olive Willey (page 22, top) where I have reported that th from the Comple e care they rece ived x Care Hub staff analyses of the beginning program, and Winnie Smith (page 22, bottom; page peace and quiet.” was good or ex cellent of the program suggest REGAINING Winnie Smith, CCH patient that providing care for CCH I realized 23) the opportunity to FUNCTION 81% AND INDEPE remain at home while NDENCE patients may cost less than Percentage of pa for inpatients matched by how much receiving hospital-level care from a compre- reported that Co tients (n=68) wh mplex Care Hub o age, gender and diagnosis. Responses from both I never knew hensive team including physicians, nurses, and helped them rega independence qu in their function ha an d d ite a bit or comple patients and staff to date about my community paramedics like Lou Labrash. PATIENT INVO LVEMEN tely have been very positive. T patients and 84% Percentage of pa Data collected by CCH tients (n=69) wh reported always o or usually being staff over a 17-month period show the program is a hit that my care involved as muc h as they wanted to be in decision with patients: was never and treatment s about their care −− On average, patients rated their overall expe- complete. DAYS OF AC UTE CARE PR OV IDED 1,593.3 From Feb 2018 rience of the care they received on the Complex I feel this received care th – July 2019, 141 rough the Comple patients x Care Care Hub 9.5 out of 10 program is Hub, resulting in days of acute ca an estimated 1,59 3.3 Days re provided −− 96% of patients reported that the care wonderful they received from the and gives Complex Care Hub staff was good or excellent us an oppor- −− 84% of patients reported always or usually being tunity to involved as much as help people they wanted to be in decisions about their in what they care and treatment actually −− 81% of patients reported that the Complex Care need.” Hub helped them regain Anonymous Complex their function and inde- Care Hub physician pendence quite a bit or completely An anonymous CCH physician remarked, “After going through this program, I realized how much I never knew about my patients and that my care was never complete. I feel this program is wonderful and gives us an opportunity to help people in what they actually need.” While these are early positive signals, the team is embarking on a rigorous evaluation of the program as it is maturing. 22 DEPARTMENT OF MEDICINE 2018-19 ANNUAL REPORT 23
INNOVATIONS IN CLINICAL RESEARCH edical research and innova- Dr. Andrew Daly AN EXCITING NEW cancer treatment, Division Head and Zone Clinical Section Chief chimeric antigen receptor (CAR) for Hematology & Hematological Malignancies Former Director of the Alberta Blood and Bone T-cell therapy, is opening up a world tion are fundamental to the Marrow Transplant Program of potential for treating certain forms Clinical Associate Professor, of cancer and providing hope for Cumming School of Medicine people where, in many cases, there Department of Medicine, CHIMERIC ANTIGEN was little before. Essentially, CAR T-cell therapy strengthens the body’s immune system and pushes it harder RECEPTOR T-CELL UCalgary, and AHS. Researchers acquire (CAR T-CELL) to fight cancer cells. The type of genetic immunother- apy re-engineers a patient’s own cells CONTRIBUTORS Dr. Andrew Daly Dr. Kara Nerenberg evidence and improve—or discover— THERAPY from their immune system, giving them instructions to attack cancer cells, and injects them back into the body. The treatments that help people here in Alberta Liz Deneer Clinical trials are underway in process creates what is essentially Sandra Burk (patient) Calgary to use immunotherapy, a living drug—one that’s individually a sort of “living drug,” to target customized for each patient. and around the world. DIVISIONS INVOLVED Hematology & certain blood cancers. The first CAR T-cells were Hematological developed in the 1980s but it has Malignancies taken tremendous time and effort to General Internal Medicine make them work says Dr. Andrew Every year, UCalgary and AHS support thousands of new These mothers are at a higher risk for heart attack and Daly, Division Head and Zone Clinical and ongoing studies that use UCalgary and AHS facilities, even premature death. In this chapter you will read about Section Chief for Hematology and patient data and systems. In fact, Alberta has a higher an innovative research, new clinics and telephone health Hematological Malignancies in the clinical trial enrolment rate than the national average. coaching program that is helping reduce women’s long-term Department of Medicine, former In this chapter you will read about new clinical trials that risk factors of having high blood pressure during pregnancy. director of the Alberta Blood and are testing an innovative and exciting immunotherapy to treat As members of the Department pursue their research Bone Marrow Transplant Program some types of cancer. Chimeric Antigen Receptor T-Cell and perform clinical trials, the Department, UCalgary and and Clinical Associate Professor with therapy is a type of “living drug” that is able to strengthen the AHS work with them, helping these world-class researchers the Cumming School of Medicine and patient’s own immune system, pushing it to work harder and translate their discoveries from ‘bench to bedside’ and improve Arnie Charbonneau Cancer Institute target certain blood cancers. the health and lives of people who live in Alberta and around at the University of Calgary. Women who have high blood pressure when they’re the world. pregnant often think their issues go away after their baby is born. But researchers have determined that they’re likely to continue to have problems long after they’ve had their babies. 24 DEPARTMENT OF MEDICINE 2018-19 ANNUAL REPORT 25
“We’ve been leaders in stem PREVIOUS PAGE Dr. Andrew Daly discusses CAR T-cells Clinical trials have been happening in various locations for the past few Daly is a recognized leader in stem cell therapy and transplantation. cell transplants for years, and years. Now, Daly and his team have He made headlines in May 2019 after with a patient on the Hematology Unit at the started clinical trials that will help performing a stem cell transplant for Foothills Medical Centre. advance CAR T-cell therapy and provide Revée Agyepong. She was the first Dr. Daly and his team have started clinical trials that will help advance renewed hope and improve the lives of Albertans. “There are two established indications for CAR T-cells right now,” adult in Alberta whose sickle cell anemia was cured with this treatment, freeing her from the debilitating disease so this is a CAR T-cell therapy. PAGE 26: Jillian de Groot, a he says. “One is relapsed, or refractory, acute lymphoblastic leukemia, or ALL. that caused excruciating pain and was slowing killing her major organs. This new opportu- nity to look at That’s the childhood type of leukemia, success was the latest to reinforce Registered Nurse on Unit 57 at the Foothills and then the indication in adults is Alberta’s leadership in stem cell Hospital, begins to relapsed or refractory aggressive research and cancer treatment. Now, prepare a patient for an infusion of CAR T-cells, a process similar to a non-Hodgkin lymphoma.” Daly and his colleagues at Alberta Children’s Hospital have Daly is applying the expertise to CAR T-cell research, making advancements that will open the doors to more “firsts” a different type blood transfusion. PAGE 27: After the CAR T-cells begun clinical trials treating children who have ALL and he hopes to treat in Alberta health care. of transplant product.” adults with non-Hodgkin lymphoma on PUSHING THE BOUNDARIES are created and multi- plied in Alberta Public similar trials. “My estimate is thirty or OF MEDICAL SCIENCE Laboratory’s Cellular forty patients per year would have a In addition to trials in leukemia and Therapy Lab, they disease that is eligible for CAR T-cells. lymphoma, Daly is collaborating on Dr. Andrew Daly are cryopreserved in Not every patient is going to be well a clinical trial in a different blood liquid nitrogen. enough to get them,” he says. cancer, multiple myeloma. “In multiple Daly specializes in the transplan- myeloma, the CAR T-cell actually tation of hematopoietic stem cells targets something different compared – bone marrow cells that have the to what’s being targeted in the other remarkable ability to develop into white two diseases that are treated.” His blood cells, red blood cells or platelets. colleague Dr. Nizar Bahlis, Clinical “We have an improved understand- Associate Professor with the ing of how to engineer cells plus an Cumming School of Medicine and improved understanding of how the member of the Division of Hematology immune system works,” he says. & Hematological Malignancies, is “Those are two very powerful tools principal investigator of the multiple that are coming together and leading myeloma project. to better treatments for patients.” 26 DEPARTMENT OF MEDICINE 2018-19 ANNUAL REPORT 27
CAR T-CELL THERAPY: HOW IT WORKS Chimeric antigen 3 receptor (CAR) T-cell therapy is a new, individualized cancer treatment that boosts the patient’s own immune system to fight cancer cells. Here’s 2 how it works: STEP 1 Collect the patient’s T-cells from their immune system. STEP 2 Load the chimeric antigen receptor (CAR) onto the surface of the T-cells creating CAR T-cells with “Making CAR “Because we 1 4 instructions to look for certain cancer cells. T-cells work have a really STEP 3 Multiply the CAR T-cells in the lab. clinically took Daly and his team are also looking to take part in another study that “Some people may look at the prospect of a two week hospitalization, being good name PAGE 28 Once the patient’s T-cells have been STEP 4 a lot of work. in cancer involves manufacturing CAR T-cells away from home, possibly ending up Give the patient chemother- collected, the chimeric “in house”. Due to the complexity of with really serious toxicity and say, apy to reduce the number of antigen receptor (CAR) the CAR T-cell manufacturing process, ‘You know, that’s not for me.’” is loaded onto the cancer cells in their body. They’ve been most of these products are manufac- tured by the pharmaceutical industry, which adds to the cost of treating That’s because roughly one-third of those who receive CAR T-cells require hospitalization in intensive clinical trials surface of the T-cells, creating the CAR T-cells, on this machine Put millions of CAR T-cells into the patient’s doing clinical in general, in the Alberta Public blood stream. patients. Daly’s team has joined forces care for a week or more. Because of Laboratory’s Cellular with researchers at the University of this consideration, Daly estimates their Therapy Lab at the The CAR T-cells will trials with CAR people are Alberta and the University of Ottawa capacity will be 26 to 30 patients per Foothills Medical Centre. continue to multiply in in order to develop the expertise year to begin with. “We’re planning to the blood stream. PAGE 29 necessary to manufacture CAR T-cells Daly is excited to think of a day keep people in hospital for about two Dr. Andrew Daly on T-cells for the in Alberta Public Laboratory’s Cellular Therapy Lab, located in Calgary. The Calgary team was approached to take when CAR T-cell therapy may even be applied to cancers in which the immune system doesn’t play such a central role, weeks, and in order to be respectful of the other areas of the hospital, and the other resources in the hospital, we’re starting to Hematology Unit 57 at the Foothills Medical Centre. STEP 5 The CAR T-cells look for and set out to destroy last five or part because of the existing equipment and expertise made possible by the such as cancer of the colon or kidney. He points out that while these are going to start off by treating one patient every two weeks,” he says. “So we will look at us 5 cancer cells that have a specific antigen. six years.” now as a place strength of the research partnership of challenging to treat with immunother- try not to have more than one patient After receiving CAR T-cell Alberta Health Services, Alberta Public apy, “people are trying to develop CAR getting CAR T-cells in the hospital at therapy, patients stay in Laboratories, Cumming School of T-cells that actually function in those any one time.” the hospital and are Dr. Andrew Daly Medicine and the University of Calgary. Alberta’s international reputation as a leader in cancer clinical trials makes this environments, and when that happens this field will explode.” Over the years, Daly and other researchers have made tremendous progress exploring the intricacy and to do CAR monitored and treated for any side effects. province a logical place for this sort of cutting edge research. “We have a fairly THE CHALLENGES While the potential for living drug complexity of the human body to understand how CAR T-cell therapies T-cell studies CAR T-cells may stay active in the body and prevent the as well.” small population and we’re really spread therapy is very exciting, CAR T-cells can work and they are continuing to cancer from returning. out,” he says. “But what we’ve done have an unfortunate element in push the boundaries and learn new is we’ve really gotten out there, sold common with other cancer treatments: knowledge that will save lives. ourselves, developed the infrastructure, it can make patients extremely ill. Dr. Andrew Daly developed the standard operating pro- Daly says some patients may even cedures, and because we have a really turn away the treatment. “Not every good name in cancer clinical trials in patient is going to want to receive them general, people are starting to look at us because of the toxicity and because of now as a place to do CAR T-cell studies.” the unpredictable journey,” he says. 28 DEPARTMENT OF MEDICINE 2018-19 ANNUAL REPORT 29
“Women in Canada are Dr. Kara Nerenberg Associate Professor, Division of General Internal Medicine UP TO ONE IN 10 Canadian women will experience a high blood pressure She received funding through Heart and Stroke and CIHR as one of the starting to indicate how many women have their cholesterol and diabetes blood tests PAGE 30 Dr. Kara Nerenberg, who received funding have heart Cumming School of Medicine disorder in pregnancy (HDP), making recipients of the Women’s Heart and and the results. from the Heart and them two to five times more likely to Brain Health Chairs awards, a program This information will provide vital Stroke Foundation have a heart attack or stroke before the designed to generate new knowledge insight into the best ways to reach PROGRAM TO and CIHR as one of IMPROVE THE age of 40 and die before they reach 60. Even more troubling is that roughly half of Canadian physicians are not aware that improves awareness, prevention and understanding of how biology and socio-cultural factors affect women’s attacks and women after they’ve had their babies. It begins with improving clinic attendance. Nerenberg’s research indicates 25 the recipients of the Mid-Career Women’s Heart and Brain Health HEART AND of this risk, so they aren’t able to inform their patients. heart and brain health. The funding also allowed Nerenberg to bring together 17 stroke even in per cent of new moms don’t show up for their first post-partum visit and that Chair awards, leads the IMPROVE program. PAGE 31 BRAIN HEALTH their 30s and Dr. Kara Nerenberg is determined to other post-partum clinics from across grows to 50 per cent for later follow-up Calgary mom Sandra give young women the tools they need the country and form a national network visits. “There’s quite a big gap for these Burke was referred to OF POST-PARTUM to take charge of their health through that’s developing best practices for women in terms of follow-up because the IMPROVE clinic in CANADIAN WOMEN the new clinic IMPROVE (Identifying Methods for Postpartum Reduction Of Vascular Events). She focuses on managing women’s cardiovascular health after pregnancy. “Specialized follow-up clinics for they’re dying it falls between the fields of obstetrics, primary care and internal medicine,” says Nerenberg. “To bridge that gap June, 2018. Research, new clinics and a telephone health coaching finding the best ways to prevent heart attacks and strokes in young women women after pregnancy across Canada have started working together to share in their 50s. we’ve done a couple things here in Calgary such as starting a clinic called We can’t wait who were diagnosed with high blood clinic information so we can find out if PreVASC, a post-partum cardiovascu- program for new moms are pressure in pregnancy—roughly seven specialty clinics work better than usual lar risk reduction clinic, as well as our helping to reduce women’s per cent of all pregnancies in Alberta. care clinics at finding and treating the IMPROVE post-partum clinic.” long-term risk factors of having high blood pressure For example, preeclampsia, a condition which includes high blood pressure, dis- appears shortly after a woman delivers heart and stroke risk factors,” says Nerenberg. “These specialists will also help us develop and test tools to help until they’re 40 But these clinics can’t help if women aren’t showing up for their appointments. New moms can face to 50 to start during pregnancy. her baby. But new research shows that doctors take better care of their patients. a number of challenges to get to the the blood vessel damage that occurred If these tools work, we can test these clinic—caring for a little child can treatments.” during pregnancy, causing stiffening can tools in different clinics across Alberta make it difficult to travel to a medical lead to accelerated atherosclerosis— as another starting point.” appointment and they may not have hardening of the arteries. Nerenberg is leading the very first the money to pay for child care or the “Women in Canada are starting to study to examine where, when and Dr. Kara Nerenberg additional expenses associated with have heart attacks and stroke even in why women visit their doctors after travelling such as fuel and parking. their 30s and they’re dying in their 50s,” pregnancy. This involves accessing After conducting surveys of new says Nerenberg. “So we can’t wait health databases that already collect moms, it made sense to create a until they’re 40 to 50 to start treat- information on women in Alberta and program that would bring help to them. ments. We have to start in their 30s.” 30 DEPARTMENT OF MEDICINE 2018-19 ANNUAL REPORT 31
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