Webinars A series of live, interactive 2021/22 - PVRI - Pulmonary Vascular ...

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Webinars A series of live, interactive 2021/22 - PVRI - Pulmonary Vascular ...
SU PPORTED   BY

                                                               PVRI
                                                               Pulmonary Vascular
                                                                Research Institute

                  webinars
                                                   The research continues.

                   A series of live, interactive

                                                      2021/22
                      Please join us for these exciting new online meetings.

                                                             programme
Webinars A series of live, interactive 2021/22 - PVRI - Pulmonary Vascular ...
PVRI
                                                                                                                                                     Pulmonary Vascular
                                                                                                                                                      Research Institute

                                               “I am pleased to announce a series of
                                         webinars and online meetings that continue
                                              the fantastic work of the PVRI for our
                                              global members and young scientists.”
                                         In the absence of the PVRI in-person meetings and symposia, these online webinars
                                      will enable us to stay in contact with our worldwide community, but also to explore
werner seeger                                                                      and discuss important new research.
President 2020-2022,                    Following the success of the DDS 2020 DIGITAL online Drug & Development
Justus-Liebig University giessen,
germany
                                     Symposium in June 2020, we are excited to launch this series of interactive live
                                    webinars and look forward to active discussion and debate throughout the year.
                                    The International Consortium for Genetic Studies in Pulmonary
                                           Arterial Hypertension (PAH-ICON) has organised seven
                                            webinars. we thank Nick Morrell and his colleagues for
                                                                        organising these meetings.
                                             During the live webinar sessions, there will be plenty of time set aside for Q&a to encourage
                                                active participation from our audience. all presentations will be available to download after
                                                      the event. we encourage you to participate in this exciting new feature and register online.

                                                                                                                 ReGISTRATION IS FRee FOR PVRI PAID MeMbeRS.
Webinars A series of live, interactive 2021/22 - PVRI - Pulmonary Vascular ...
PVRI
                                                                                                                                                                                               Pulmonary Vascular
                                                                                                                                                                                                Research Institute

                                                                                                                                                       Introducing the
                                                                                      Scientific Organisers...
                                                                                                                                We would like to thank our Scientific Organising Committee,

Our Scientific Leaders...
                                                                                                                    under the leadership of Patricia Thistlethwaite and Stephan Rosenkranz,
                                                                                                                        for putting together such an outstanding programme of stimulating
                                                                                                                                                                             and novel talks.
                                                                                                                        Many thanks also to all chairs, speakers and abstract presenters for contributing to
                                                                                                                                                                                  this exciting new feature.
                  Patricia Thistlethwaite                       Stephen Rosenkranz
                  • University of California,                   • University of Cologne,                                   Details of the abstract submission process and how to register for the webinars
                    San Diego, USA                                Germany                                                                                                           will soon be available.

Our Scientific Planning Committee...

              Sébastien Bonnet                  Allan Lawrie                               Stelios Orfanos                              Rogerio Souza                               Rebecca Vanderpool
              • Laval University,               • University of Sheffield,                 • University of Athens                       • University of Sao Paulo,                  • University of Arizona
                Canada                            UK                                         Medical School,                              Brazil                                      College of Medicine
                                                                                             Greece                                                                                   - Tuscon, USA
Webinars A series of live, interactive 2021/22 - PVRI - Pulmonary Vascular ...
PVRI
                                                                                                                                                                                        Pulmonary Vascular
                                                                                                                                                                                         Research Institute

                                                                                             Dates and topics for the webinar series in 2021:

    Webinars
   coming up in
                                                                                                 27                  24                         15                   24                    12
                                                                                               January             Febuary                     March                March                 April
                                                                                             Around the globe:   Keynote lecture            Healthy carriers      Connection          Mitochondrial

      2021
                                                                                              Global burden         session                    of BMPR2            between             genes and
                                                                                               of pulmonary                                    mutations         COVID-19 and             PAH
                                                                                               hypertension                                 - screening and       pulmonary
                                                                                                                                              new insights      vascular disease

                                                                                                                         5
                                                                                                   28                   May                      10                  26                    23
                                                                                                  April              World                       May                 May                  June

              SAVE THE DATES
                                                                                                                   Pulmonary
                                                                                                                  Hypertension
                                                                                              Virtual poster          Day                       ClinGen:         Novel imaging       Joint Symposium
                                                                                               discussion            LONGEVITY                Defining the       approaches in         with the ESC:
                                                                                                session 1         A bridge to a bridge...      genes and          pulmonary           The pulmonary
                                                                                                                      Inaugural               variants that      hypertension        circulation in the
                                                                                                                    IDDI Webinar               cause PAH           patients             heart failure

Calendar of
                                                                                                   12                    28                      25                  13                  29

events...
                                                                                                  July                  July                   August            September           September
                                                                                               Metabolomics          PRO-CON                  The notch              TBX4,           Beyond DNA: The
                                                                                              and proteomics          debate                  receptors:         developmental        unseen genome
                                                                                                  in PAH             session 1              Multi-regulators    lung disease and     and novel omics
                                                                                                                                                of PAH             pulmonary           approaches to
                                                                                                                                             development          hypertension              PH

PVRI webinars arranged in 2021                                                                   21                  27                         15                  24                   15
                                                                                               October             October                   November            November             December
Webinars take place on the last Wednesday of each month from 15:00-17:00
(all times are indicated in UK time - GMT or BST dependant on date) so you can                  Pulmonary
                                                                                              Veno-Occlusive
                                                                                                                 Joint Symposium
                                                                                                                  with the ISHLT:
                                                                                                                                              The genetics of
                                                                                                                                             scleroderma-as-
                                                                                                                                                                Machine learning
                                                                                                                                                                   and artificial
                                                                                                                                                                                         PRO-CON
                                                                                                                                                                                     debate session 2:
easily schedule these in your calendars.                                                     Disease: Genetics    End-stage PAH             sociated PAH and       intelligence         Medical vs
                                                                                                and clinical      - how and what             vasoresponders       approaches for        surgical or
          We are also pleased to present a series of seven PAH-ICON Genomic                     phenotypes           do we do in                                    PH: From          interventional
          Webinars incorporated into the programme for this year.                                                      2021?                                    screening to novel      therapy for
                                                                                                                                                                   drug targets           CTEPH
Click on each meeting for further information on chairs, speakers and presentation topics.
Webinars A series of live, interactive 2021/22 - PVRI - Pulmonary Vascular ...
PVRI
                                                                                                                                                 Pulmonary Vascular
                                                                                                                                                  Research Institute

                                                                             Dates and topics for the webinar series in 2022:

    Webinars
   coming up in
                                                                                 26               23              30                27             25
                                                                               January         February          March             April           May
                                                                               Vitual poster   Bone marrow       Ageing and    The association   Paediatric

      2022
                                                                                discussion     modulation of     pulmonary     between cancer       PH
                                                                                 session 2      pulmonary      hypertension:      and PH:
                                                                                                 vascular      An endemic on    A tale of two
                                                                                                 disease        the horizon?      diseases

              SAVE THE DATES

Calendar of
events...
PVRI webinars arranged in 2022
Webinars take place on the last Wednesday of each month 15:00-17:00
(all times are indicated in UK time - GMT or BST dependant on date) so you
can easily schedule these in your calendars.
Click on each meeting for further information on chairs, speakers and
presentation topics.
Webinars A series of live, interactive 2021/22 - PVRI - Pulmonary Vascular ...
Presentations

Webinar 1                                                                                                                              if not all questions can be answered on the day,

Date // 27 January 2021
                                                                                                                                 all comments will be published and circulated to all
                                                                                                                                                       participants after the webinar.

                                                               noTe: all times indicated are Greenwich Mean Time (gmT)

Around the globe:
Global burden of pulmonary hypertension
Chairs & moderators: // paul Corris UniversiTy of newCasTLe, UK
                     // stylianos orfanos UniversiTy of aThens meDiCaL sChooL, greeCe
                     // rogerio souza UniversiTy of sao paULo, braziL
                     // helen whitford The aLfreD hospiTaL, aUsTraLia

Presentations                                                                                                          15:00-17:00

introduction by werner seeger // Pvri PresiDent 2020-2022. Justus-Liebig university giessen, germAny

The view of the world heart federation (whf)                                                                           15:00-15:15
Presenter: // Fausto Pinto LisbOn meDicAL schOOL, POrtugAL & PresiDent eLect WOrLD heALth FeDerAtiOn 2019-20
Discussion                                                                                                             15:15-15:22

right heart failure in africa                                                                                          15:22-15:37
Presenter: // Ana Olga mocumbi ministry OF heALth, mOzAmbique & cO-chAir OF the LAncet ncDi POverty cOmmissiOn
Discussion                                                                                                             15:37-15:45

Update on the global burden of ph project of the institute for health metrics                                          15:45-16:00
and evaluation (ihme)
Presenter: // sophia emmons-bell institute FOr heALth metrics AnD evALuAtiOn (ihme), usA
Discussion                                                                                                             16:00-16:08

pvri goDeep: perspectives of a global meta-registry                                                                    16:08-16:23
Presenter: // Werner seeger Justus-Liebig university giessen, germAny
Discussion                                                                                                             16:23-16:30

best abstract: mortality of idiopathic/hereditary and connective tissue disease-                                       16:30-16:40
associated pah: The data from first single center prospective registry in indonesia
Presenter: // Anggoro budi hartopo DePArtment OF cArDiOLOgy AnD vAscuLAr meDicine, gADJAh mADA university, inDOnesiA
Discussion                                                                                                             16:40-16:45

best abstract: Triple therapy in pulmonary arterial hypertension in an expert center                                   16:45-16:55
in mexico City. real-life results.
Presenter: // humberto garcia-Aguilar nAtiOnAL meDicAL center, mexicO city, mexicO
Discussion                                                                                                             16:55-17:00

SUPPORTED           B Y                                                                                                                                                                    back to
                                                                                                                                                                                          calendar
Webinars A series of live, interactive 2021/22 - PVRI - Pulmonary Vascular ...
Congratulations go to
Niamh errington
who has been awarded the Rupert Swift Award 2020 for her abstract entitled:
a diagnostic mirna signature for pulmonary arterial hypertension using a consensus machine learning approach

Webinar 2
                                                                                                                                           if not all questions can be answered on
                                                                                                                                if not all questions can be answered on the day,
                                                                                                                                         the day, all comments will be published
                                                                                                                          all comments will be published and circulated to all
Date // 24 February 2021
                                                                                                                                         and circulated to all participants after
                                                                                                                                                 participants after the webinar.
                                                                                                                                                                    the webinar.

                                                                    noTe: all times indicated are Greenwich Mean Time (gmT)

 Keynote lecture session 2021 including the Professor Sheila Glennis Haworth
 Memorial Lecture

 Presentations                                                                                               15:00-17:00

 Keynote lecture 1                                                                                           15:00-15:30
 Chairs & moderators: // stefano ghio irCCs poLiCLiniCo san maTTeo foUnDaTion, iTaLy
                      // paul yu brigham anD women's hospiTaL, harvarD meDiCaL sChooL, Usa

 mhealth and wearables: is this the dawn of a new age for cardiovascular medicine?
 Presenter: // martin cowie imPeriAL cOLLege LOnDOn, uk
 Discussion                                                                                                   15:30-15:40

 Keynote lecture 2                                                                                           15:40-16:10
 Chairs & moderators: // reda girgis miChigan sTaTe UniversiTy, Usa
                      // horst olschewski meDiCaL UniversiTy of graz, aUsTria
 Professor Sheila Glennis Haworth Memorial Lecture
 Translational research on pulmonary arterial hypertension
 Presenter: // Jason yuan university OF cALiFOrniA sAn DiegO, usA
 Discussion                                                                                                   16:10-16:20

 best Abstracts
 Chairs & moderators: // stefano ghio irCCs poLiCLiniCo san maTTeo foUnDaTion, iTaLy
                      // reda girgis miChigan sTaTe UniversiTy, Usa
                      // horst olschewski meDiCaL UniversiTy of graz, aUsTria
                      // paul yu brigham anD women's hospiTaL, harvarD meDiCaL sChooL, Usa
 best abstract: biomarker analysis of the pULsar study: an ongoing phase 2,                                  16:20-16:28
 Double-blind, placebo-Controlled, randomized study to Compare the efficacy and
 safety of sotatercept (aCe-011) versus placebo when added to standard of Care
 for the Treatment of pulmonary arterial hypertension (pah)
 Presenter: // marchumbert PAris-sAcLAy university, FrAnce
 Discussion                                                                                                   16:28-16:32

 best abstract: switching from pDe5i to riociguat in patients with pah:                                      16:32-16:40
 The repLaCe study
 Presenter: // raymond benza OhiO stAte university, usA
 Discussion                                                                                                   16:40-16:44

 best abstract: a diagnostic mirna signature for pulmonary arterial hypertension                             16:44-16:52
                                                                                                                                                                                      back to
 using a consensus machine learning approach                                                                                                                                         calendar
 Presenter: // Niamh errington sheFFieLD institute FOr trAnsLAtiOnAL neurOscience, uk
 Discussion                                                                                                   16:52-17:00
Webinars A series of live, interactive 2021/22 - PVRI - Pulmonary Vascular ...
3
Presentation

Webinar 3                                                                                   if not all questions can be answered on the day,

Date // 15 March 2021
                                                                                      all comments will be published and circulated to all
                                                                                                            participants after the webinar.

part of the
                                                                                                      noTe: all times indicated are Greenwich Mean Time (gmT)

PAH-ICON Genomics Webinar Series
Healthy carriers of bMPR2 mutations - screening and new insights
organiser: // harm Jan bogaard amsTerDam UniversiTy meDiCaL CenTer, The neTherLanDs

france: results from the DeLphi-ii study                                              15:00 - 15:20
presenter: // David montani hopiTaUx UniversiTaires, paris-sUD, franCe

UK: Lessons learnt from the analysis of the UK national Cohort                        15:20 - 15:40
presenter: // Jennifer martin UniversiTy of CambriDge, UK

germany: genetic screening and clinical follow-up of hpah families                    15:40 - 16:00
- the heidelberg experience
presenter: // ekkehard gruenig heiDeLberg UniversiTy, germany
          // Christina eichstaedt UniversiTy of heiDeLberg, germany

break                                                                                 16:00 - 16:10

belgium: hereditary pah in Leuven                                                     16:10 - 16:30
presenter: // rozenn Quarck Uz LeUven UniversiTy hospiTaL LeUven, beLgiUm

Discussing heredity and cascade testing: guidance for a pah physician                 16:30 - 16:50
presenter: // wendy Chung CoLUmbia UniversiTy, Usa

Discussion & wrap up                                                                  16:50 - 17:00

                                                                                                                                                                     back to
                                                                                                                                                                    calendar
Webinars A series of live, interactive 2021/22 - PVRI - Pulmonary Vascular ...
Presentations

Webinar 4                                                                                                                  if not all questions can be answered on the day,

Date // 24 March 2021
                                                                                                                     all comments will be published and circulated to all
                                                                                                                                           participants after the webinar.

                                                               noTe: all times indicated are Greenwich Mean Time (gmT)

Connection between COVID-19 and pulmonary vascular disease
Chairs & moderators: // sylvia Cohen-Kaminsky UniversiTé paris saCLay, franCe
                     // marion Delcroix UniversiTy hospiTaLs of LeUven, beLgiUm
                     // TbC

Presentations                                                                                           15:00-17:00

sars-1, mers, sars-2 and more: are coronavirus infections an ubiquitous                                 15:00-15:15
part of our lives?
Presenter: // Albert Osterhaus university OF veterinAry meDicine hAnnOver, germAny
Discussion                                                                                               15:15-15:22

endothelitis and aberrant angiogenesis: mechanisms of CoviD-19 induced                                  15:22-15.37
vascular injury
Presenter: // Danny Jonigk hAnnOver meDicAL schOOL, germAny
Discussion                                                                                               15:37-15:45

venous thromboembolism in CoviD-19: prevalence and clinical picture                                     15:45-16:00
Presenter: // stavros konstantinides university meDicAL center OF mAinz, germAny
Discussion                                                                                               16:00-16:08

aCe-ii receptors: modulation of pvD in CoviD-19?                                                        16:08-16:23
Presenter: // Anna hemnes vAnDerbiLt university, usA
Discussion                                                                                               16:23-16:30

best abstract: Tricuspid regurgitation, as proxy for acute pulmonary hypertension,                      16:30-16:40
and its association with short-term outcome in severe Covid-19
Presenter: // claes Frostell kArOLinskA institute At DAnDeryD hOsPitAL, sWeDen
Discussion                                                                                               16:40-16:45

best abstract: venous and arterial thromboembolism in CoviD-19: a systematic                            16:45-16:55
review with meta-analysis
Presenter: // vicky mai quebec cArDiOLOgy AnD PuLmOnOLOgy reseArch center, LAvAL university, cAnADA
Discussion                                                                                               16:55-17:00

                                                                                                                                                                               back to
                                                                                                                                                                              calendar
Webinars A series of live, interactive 2021/22 - PVRI - Pulmonary Vascular ...
5
Presentation

Webinar 5                                                                                               If not all questions can be answered on the day,

Date // 12 April 2021
                                                                                                  all comments will be published and circulated to all
                                                                                                                        participants after the webinar.

Part of the
                                                                                                                  NOTE: All times indicated are British Summer Time (BST)

PAH-ICON Genomics Webinar Series
Mitochondrial genetics and PAH
Organiser: // Micheala Aldred INDIANA UNIVERSITY, USA & Stefan Gräf UNIVERSITY OF CAMBRIDGE, UK

Introduction                                                                                      15:00 - 15:05

Next-generation diagnostics of mitochondrial diseases:                                            15:05 - 15:45
What can be learned for PAH?
Presenter: // Patrick Chinnery PROFESSOR OF NEUROLOGY, UNIVERSITY OF CAMBRIDGE, UK

Discussion                                                                                        15:45 - 15:55

Break                                                                                             15:55 - 16:00

Mitochondrial haplogroup analysis in PAH                                                          16:00 - 16:20
Presenter: // Micheala Aldred PROFESSOR OF MEDICINE, INDIANA UNIVERSITY, USA

Mitochondrial mitophagy in hypoxia-induced pulmonary hypertension                                 16:20 - 16:35
Presenter: // Natascha Sommer GROUP LEADER, JUSTUS-LIEBIG UNIVERSITY GIESSEN, GERMANY

NFU1 gene mutation and metabolic reprogramming in PAH                                             16:35 - 16:50
Presenter: // Olga Rafikova ASSISTANT PROFESSOR OF MEDICINE, UNIVERSITY OF ARIZONA, USA

Panel discussion & wrap-up                                                                        16:50 - 17:00

                                                                                                                                                                                 Back to
                                                                                                                                                                                calendar
Congratulations go to
Prakash Chelladurai
who has been awarded the butrous young Investigator Award 2020 for his abstract entitled:
epigenome-wide profiling uncovers novel gene regulatory networks in human pulmonary arterial hypertension

Webinar 6
                                                                                                                                      if not all questions can be answered on
                                                                                                                                    the day, all comments will be published

Date // 28 April 2021
                                                                                                                                    and circulated to all participants after
                                                                                                                                                               the webinar.

                                                                      noTe: Times indicated are british Summer Time (bsT)

 Virtual poster discussion session 1                                                                                                Round 2 CLINICAL                                                         16:00-17:00
                                                                                                                                    Chairs & moderators: // Christophe guignabert
                                                                                                                                                                  UniversiTé paris-saCLay, franCe
                                                                                                                                                               // anton vonk noordegraaf
 Presentations                                                                                                        15:00-17:00                                 amsTerDam UniversiTy meDiCaL CenTer, The neTherLanDs
                                                                                                                                                               // Khodr Tello
                                                                                                                                                                  JUsTUs-Liebig UniversiTy giessen, germany

 Round 1 bASIC                                                                                                        15:00-16:00   poster 1: equivalent outcomes for hereditary and idiopathic pulmonary arterial                                     16:00-16:05
 Chairs & moderators: // brian graham UniversiTy of CaLifornia san fransisCo, Usa
                      // Tim Lahm inDiana UniversiTy meDiCaL CenTer, Usa                                                            hypertension in children; an analysis from a national australian registry
                      // evangelos michelakis UniversiTy of aLberTa, CanaDa                                                         Presenter: // katherine kearney graham university OF neW sOuth WALes, AustrALiA
                                                                                                                                    Discussion                                                                                                         16:05-16:10
 poster 1: Therapeutically targeting endothelial cell metabolic dysfunction in                                        15:00-15:05
 pulmonary arterial hypertension with apigenin                                                                                      poster 2: effect of macitentan across prognostic age groups in patients with                                       16:10-16:15
 Presenter: // iona cuthbertson DePArtment OF meDicine, university OF cAmbriDge, uk                                                 pulmonary arterial hypertension (pah)
                                                                                                                                    Presenter: // richard channick university OF cALiFOrniA LOs AngeLes meDicAL center, usA
 Discussion                                                                                                           15:05-15:10
                                                                                                                                    Discussion                                                                                                         16:15-15:20
 poster 2: epigenome-wide profiling uncovers novel gene regulatory networks in                                         15:10-15:15
 human pulmonary arterial hypertension                                                                                              poster 3: validation of artificial intelligence artery-vein Classification for                                       16:20-16:25
 Presenter: // Prakash Chelladurai mAx-PLAnck-institute FOr heArt AnD Lung reseArch, germAny
                                                                                                                                    Contrast CT imaging in ph subjects
                                                                                                                                    Presenter: // Pietro nardelli brighAm AnD WOmen's hOsPitAL, hArvArD meDicAL schOOL, usA
 Discussion                                                                                                           15:15-15:20
                                                                                                                                    Discussion                                                                                                         16:25-16:30
 poster 3: implication of the histone methyltransferase “g9a” in pulmonary arterial                                   15:20-15:25
                                                                                                                                    poster 4: efficacy in patient subgroups in the inCrease Trial, a phase iii Trial                                    16:30-16:35
 hypertension
                                                                                                                                    to evaluate inhaled Treprostinil in patients with pulmonary hypertension due to
 Presenter: // charifa Awada the university institute OF cArDiOLOgy AnD PuLmOnOLOgy OF quebec, cAnADA
                                                                                                                                    parenchymal Lung Disease
 Discussion                                                                                                           15:25-15:30
                                                                                                                                    Presenter: // victor tapson ceDArs-sinAi meDicAL cente, usA
                                                                                                                                    Discussion                                                                                                         16:35-16:40
 poster 4: perinatal exposure to serotonin re-uptake inhibitor causes mild                                            15:30-15:35
 pulmonary hypertension in adult female rats
                                                                                                                                    poster 5: acetazolamide and high altitude pulmonary edema prevention                                               16:40-16:45
 Presenter: // barbora kaftanová DePArtment OF PhysiOLOgy, chArLes university secOnD meDicAL schOOL, czech rePubLic
                                                                                                                                    Presenter: // erik swenson university OF WAshingtOn, usA
 Discussion                                                                                                           15:35-15:40   Discussion                                                                                                         16:45-16:50

 poster 5: endothelial overexpression of sirt3 protects the metabolic etiology in pah                                 15:40-15:45   poster 6: Telomeric Tankyrases: a novel and propitious target to ameliorate the                                    16:50-16:55
 Presenter: // Anandharajan rathinasabapathy vAnDerbiLt university meDicAL centre, usA                                              maladaptation phenomena at heights
 Discussion                                                                                                           15:55-15:50   Presenter: // manjula miglani srm university, hAryAnA, inDiA
                                                                                                                                    Discussion                                                                                                         16:55-17:00
 poster 6: axl is a novel modulator of bone morphogenetic protein receptor 2 in                                       15:50-15:55
 pulmonary arterial hypertension
 Presenter: // tatyana novoyatleva Justus-Liebig-university giessen, germAny                                                        CMe Credits
                                                                                                                                    This event has been accredited by both the european accreditation Council for
                                                                                                                                                                                                                                                                      back to
 Discussion                                                                                                           15:55-16:00   Continuing medical education (eaCCme) and the european board for accreditation in
                                                                                                                                    pneumology (ebap). physicians may convert eaCCme® credits to an equivalent number
                                                                                                                                                                                                                           2 CMe credits   2 CMe credits
                                                                                                                                                                                                                                                                     calendar
                                                                                                                                    of ama pra Category 1 CreditsTm.
7
Presentation

Webinar 7                  If not all questions can be answered on the day,

Date // 5 May 2021
                          all comments will be published and circulated to
                                           all participants after the webinar.

                                                            LONGEVITY
                                                             Keynote Speaker                A bridge to a bridge...
                                                                      Dr Martine Rothblatt FOUNDER & CEO OF UNITED THERAPEUTICS, USA

                                                             Chairs/moderators
                                                                      Sir Magdi Yacoub                     Professor Werner Seeger
                                                                      THE MAGDI YACOUB INSTITUTE,          PVRI PRESIDENT 2020-22,
                                                                      HEART SCIENCE CENTRE,                JUSTUS-LIEBIG-UNIVERSITY GIESSEN,
                                                                      HAREFIELD HOSPITAL, UK               GERMANY

                                                             Keynote presentation by Dr Martine Rothblatt                       10:00 - 10:40 EDT
                                                             The presentation will summarise what therapies are                 15:00 - 15:40 BST
                                                             currently available for patients who suffer from PH and
                                                             the technological advances that enable us to develop
                                                             transplant organs ‘in the lab’ in an attempt to provide
                                                             patients all over the world with transplant options where
                                                             currently no transplant registers are available, or there is
                                                             a very limited supply of suitable organs.

                                                             Q&A session                                                        10:40 - 11:00 EDT
                                                             Moderated by Sir Magdi Yacoub &                                    15:40 - 16:00 BST
                                                             Professor Werner Seeger

                                                                                                                                                Back to

 Inaugural IDDI Webinar on World Pulmonary Hypertension Day
                                                                                                                                               calendar

                                                                                  Date // 5 May 2021

                                                           NOTE: Times indicated are Eastern Daily Time (EDT) and British Summer Time (BST)
  M E MB E R   OF
8
Presentation

Webinar 8                                                                 If not all questions can be answered on the day,

Date // 10 May 2021
                                                                    all comments will be published and circulated to all
                                                                                          participants after the webinar.

Part of the                                                                         NOTE: All times indicated are British Summer Time (BST)

PAH-ICON Genomics Webinar Series
ClinGen: Defining the genes and variants that cause PAH
Organiser: // Wendy Chung COLUMBIA UNIVERSITY

PH Gene Curation Expert Panel and PAH gene curation overview        15:00 - 15:15
Presenter: // Carrie Welch COLUMBIA UNIVERSITY

Detailed curation: KDR                                              15:15 - 15:30
Presenter: // Arjan Houweling UNIVERSITY MEDICAL CENTER AMSTERDAM

Curation summary: BMPR2                                             15:30 - 15:38
Presenter: // Carrie Welch COLUMBIA UNIVERSITY

Curation summary: TBX4                                              15:38 - 15:46
Presenter: // Micheala Aldrich INDIANA UNIVERSITY

Curation summary: KCNK3                                             15:46 - 15:54
Presenter: // Laura Southgate ST. GEORGE’S UNIVERSITY OF LONDON

Break                                                               15:54 - 16:04

Curation summary: SMAD9                                             16:04 - 16:12
Presenter: // Stefan Gräf UNIVERSITY OF CAMBRIDGE

Curation summary: GDF2                                              16:12 - 16:20
Presenter: // Rajiv Machado ST. GEORGE’S UNIVERSITY OF LONDON

Curation summary: ATP13A3                                           16:20 - 16:28
Presenter: // Jair Tenorio UNIVERSITY HOSPITAL LA PAZ, MADRID

Curation summary: AQP1                                              16:28 - 16:36
Presenter: // Christina Eichstaedt HEIDELBERG UNIVERSITY

ClinGen PH GCEP Future directions                                   16:36 - 16:42
Presenter: // Wendy Chung COLUMBIA UNIVERSITY
                                                                                                                                                   Back to
Questions/discussion                                                16:42 - 17:00                                                                 calendar
Presentations

Webinar 9                                                                                                                                     if not all questions can be answered on the day,

Date // 26 May 2021
                                                                                                                                        all comments will be published and circulated to all
                                                                                                                                                              participants after the webinar.

                                                                                    noTe: Times indicated are british Summer Time (bsT)

Novel imaging approaches in pulmonary hypertension patients
Chairs & moderators: // David Kieley UniversiTy of sheffieLD, UK
                     // David Levin mayo CLiniC, Usa
                     // Lan zhao imperiaL CoLLege LonDon, UK

Presentations                                                                                                                 15:00-17:00

Update from the fleischner society Task force for imaging in pulmonary                                                        15:00-15:15
hypertension
Presenter: // martine remy university centre OF LiLLe, FrAnce
Discussion                                                                                                                    15:15-15:24

molecular imaging of pulmonary vascular disease using microvascular                                                           15:24-15:39
endothelial cell ligands
Presenter: // Jocelyn Dupuis mOntreAL heArt institute, cAnADA
Discussion                                                                                                                    15:39-15:48

mri to assess pulmonary vascular changes and ph progression                                                                   15:48-16:03
Presenter: // Jens vogel-claussen hAnnOver meDicAL schOOL, germAny
Discussion                                                                                                                    16:03-16:12

xenon magnetic resonance imaging signatures of ph                                                                             16:12-16:27
Presenter: // sudarshan rajagopal Duke university meDicAL center, usA
Discussion                                                                                                                    16:27-16:36

synchrotron-based phase contrast micro-CT imaging of pulmonary vascular                                                       16:36-16:51
disease in human tissue and animal models
Presenter: // karin tran-Lundmark LunD university, sWeDen
Discussion                                                                                                                    15:51-17:00

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CMe Credits                                                                                                                                                                                      calendar
This event has been accredited by both the european accreditation Council for
Continuing medical education (eaCCme) and the european board for accreditation in            2 CMe credits        2 CMe credits
pneumology (ebap). physicians may convert eaCCme® credits to an equivalent number
of ama pra Category 1 CreditsTm.
Presentations

Webinar 10                                                                                                                                    If not all questions can be answered on the day,

Date // 23 June 2021
                                                                                                                                        all comments will be published and circulated to all
                                                                                                                                                              participants after the webinar.

                                                                                    NOTE: Times indicated are British Summer Time (BST)

Joint Symposium with the ESC:
The pulmonary circulation in the heart failure syndrome
Chairs & moderators: // Sophia Airhart UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE, USA
                     // Michele D´Alto MONALDI HOSPITAL, ITALY
                     // George Giannakoulas AHEPA UNIVERSITY HOSPITAL, GREECE

Presentations                                                                                                                 15:00-17:00

The right ventricle in HFpEF                                                                                                  15:00-15:15
Presenter: // Marco Guazzi UNIVERSITY OF MILAN, ITALY
Discussion                                                                                                                    15:15-15:22

Genetic aspects in Group2 PH                                                                                                  15:22-15.37
Presenter: // Mark Toshner UNIVERSITY OF CAMBRIDGE, UK
Discussion                                                                                                                    15:37-15:45

Exercise haemodynamics in heart failure: What can we learn from invasive CPET?                                                15:45-16:00
Presenter: // Gabor Kovacs MEDICAL UNIVERSITY OF GRAZ, AUSTRIA
Discussion                                                                                                                    16:00-16:08

Systemic consequences and interorgan cross-talk in heart failure and PH                                                       16:08-16:23
Presenter: // Stephan Rosenkranz UNIVERSITY OF COLOGNE, GERMANY
Discussion                                                                                                                    16:23-16:30

Best abstract: The Natriuretic Peptide Clearance Receptor Selectively Causes                                                  16:30-16:40
Right Ventricular Dysfunction in a Model of Pulmonary Hypertension and Heart
Failure with Preserved Ejection Fraction
Presenter: // Vineet Agrawal VANDERBILT UNIVERSITY MEDICAL CENTER, USA
Discussion                                                                                                                    16:40-16:45

Best abstract: N-Lysine methyltransferase Smyd2-mediated HIF-1A stabilization                                                 16:45-16:55
plays a protective role in RV hypertrophy
Presenter: // Swathi Veeroju JUSTUS-LIEBIG UNIVERSITY, GIESSEN, GERMANY
Discussion                                                                                                                    16:55-17:00

                                                                                                                                                                                                  Back to
CME Credits                                                                                                                                                                                      calendar
This event has been accredited by both the European Accreditation Council for
Continuing Medical Education (EACCME) and the European Board for Accreditation in            2 CME credits        2 CME credits
Pneumology (EBAP). Physicians may convert EACCME® credits to an equivalent number
of AMA PRA Category 1 CreditsTM.
11
presentation

Webinar 11                                                                                                 If not all questions can be answered on the day,

date // 12 July 2021
                                                                                                     all comments will be published and circulated to all
                                                                                                                           participants after the webinar.

Part of the                                                                                                          NOTE: All times indicated are British Summer Time (BST)

PAH-ICON Genomics Webinar Series
Using the plasma proteome and metabolome to understand pulmonary hypertension
Organisers: // Martin Wilkins IMPERIAL COLLEGE LONDON, UK & Anna Hemnes VANDERBILT UNIVERSITY, USA

Welcome                                                                                              15:00 - 15:05
Presenter: // Martin Wilkins IMperIal College london, UK

First session
Chair: // Martin Wilkins IMPERIAL COLLEGE LONDON, UK

Generation of a protein panel for risk prediction from 4,100 plasma proteins                         15:05 - 15:20
Presenter: // Chris rhodes IMperIal College london, UK

Mining the plasma proteome to inform pathobiology of PAH                                             15:20 - 15:35
Presenter: // lars Harbaum IMperIal College london, UK

Comparison of Somascan and Olink measurements of the plasma proteome                                 15:35 - 15:50
to understand disease
Presenter: // Maik pietzner UnIversIty of CaMbrIdge, UK

Questions/discussion                                                                                 15:50 - 16:00

Second session
Chair: // Anna Hemnes VANDERBILT UNIVERSITY, USA

Insights from PVDOMICs                                                                               16:00 - 16:15
Presenter: // Jane leopold Harvard UnIversIty, Usa

The metabolome in PAH                                                                                16:15 - 16:30
Presenter: // Mona alotaibi UnIversIty of CalIfornIa san dIego, Usa

Immunophenotyping                                                                                    16:30 - 16:45
Presenter: // andy sweatt stanford UnIversIty, Usa

Questions/discussion                                                                                 16:45 - 17:00                                                                   Back to
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Webinar 12                                                                                                                                    If not all questions can be answered on the day,

Date // 28 July 2021
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                                                                                    NOTE: Times indicated are British Summer Time (BST)

PRO-CON debate session 1

Presentations                                                                                                                 15:00-17:00

Topic A:
Role of pulmonary vascular pruning in PAH                                                                                     15:00-16:00
Chairs & moderators: // Serpil Erzurum CLEVELAND CLINIC, USA
                     // Steeve Provencher LAVAL UNIVERSITY, CANADA
                     // Aaron Waxman BRIGHAM AND WOMEN'S HOSPITAL, HARVARD MEDICAL SCHOOL, USA
PRO:                                                                                                                          15:00-15:15
A hopeless cause: The pulmonary vasculature is largely gone and
irredeemable in PAH
Presenter: // Peter Dorfmüller JUSTUS-LIEBIG UNIVERSITY, GIESSEN, GERMANY
Rebuttal                                                                                                                      15:30-15:35
CON:                                                                                                                          15:15-15:30
Remnants of lost pulmonary vasculature may be re-engaged in PAH
Presenter: // Duncan Stewart OTTAWA HOSPITAL RESEARCH INSTITUTE, CANADA
Rebuttal                                                                                                                      15:35-15:40
General discussion                                                                                                            15:40-16:00

Topic B:
Treatment of patients with mild PAH                                                                                           16:00-17:00
Chairs & moderators: // Paul Hassoun JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE, USA
                     // Allan Lawrie UNIVERSITY OF SHEFFIELD, UK
                     // Stuart Rich NORTHWESTERN UNIVERSITY FEINBERG SCHOOL OF MEDICINE, USA
                     // Zeenat Safdar HOUSTON METHODIST HOSPITAL, USA
PRO:                                                                                                                          16:00-16:15
Patients with mild pulmonary hypertension (mPAP 21-24) should be
treated with PAH approved drugs
Presenter: // David Systrom BRIGHAM AND WOMEN'S HOSPITAL, USA
Rebuttal                                                                                                                      16:30-16:35
CON:                                                                                                                          16:15-16:30
Patients with mild pulmonary hypertension (mPAP 21-24) should NOT be
treated with PAH approved drugs
Presenter: // Roham Zamanian STANFORD UNIVERSITY, USA
Rebuttal                                                                                                                      16:35-16:40
General discussion                                                                                                            16:40-17:00
                                                                                                                                                                                                  Back to
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This event has been accredited by both the European Accreditation Council for
Continuing Medical Education (EACCME) and the European Board for Accreditation in            2 CME credits        2 CME credits
Pneumology (EBAP). Physicians may convert EACCME® credits to an equivalent number
of AMA PRA Category 1 CreditsTM.
Presentations

Webinar 13                                                                                                                                    if not all questions can be answered on the day,

Date // 25 August 2021
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                                                                                                                                                              participants after the webinar.

                                                                                    noTe: Times indicated are british Summer Time (bsT)

The notch receptors:
Multi-regulators of PAH development

Chairs & moderators: // marc humbert UniversiTé paris-saCLay, franCe
                     // JinJiang pang UniversiTy of roChesTer meDiCaL CenTer, Usa
                     // rhian Touyz UniversiTy of gLasgow, UK

Presentations                                                                                                                 15:00-17:00

role of notch1 in experimental pulmonary hypertension                                                                         15:00-15:15
Presenter: // ralph schermuly Justus-Leibig university giessen, germAny
Discussion                                                                                                                    15:15-15:30

notch-bmpr interactions in endothelium in pah                                                                                 15:30-15:45
Presenter: // marlene rabinovitch stAnFOrD university, usA
Discussion                                                                                                                    15:45-16:00

notch3 is a driver and biomarker for pah                                                                                      16:00-16:15
Presenter: // Patricia thistlethwaite university OF cALiFOrniA sAn DiegO, usA
Discussion                                                                                                                    16:15-16:30

notch3 lineage and pulmonary vasculopathy                                                                                     16:30-16:45
Presenter: // maya kumar stAnFOrD university schOOL OF meDicine, usA
Discussion                                                                                                                    16:45-17:00

                                                                                                                                                                                                  back to
CMe Credits                                                                                                                                                                                      calendar
This event has been accredited by both the european accreditation Council for
Continuing medical education (eaCCme) and the european board for accreditation in            2 CMe credits        2 CMe credits
pneumology (ebap). physicians may convert eaCCme® credits to an equivalent number
of ama pra Category 1 CreditsTm.
14
Presentation

Webinar 14                                                                                                                       If not all questions can be answered on the day,

Date // 13 September 2021
                                                                                                                           all comments will be published and circulated to all
                                                                                                                                                 participants after the webinar.

Part of the
                                                                                                                                           NOTE: All times indicated are British Summer Time (BST)

PAH-ICON Genomics Webinar Series
TBX4, developmental lung disease and pulmonary hypertension
Organisers: // Eric Austin VANDERBILT UNIVERSITY MEDICAL CENTRE, USA
            // Harm Jan Bogaard AMSTERDAM UNIVERSITY MEDICAL CENTER
            // Matina Prapa UNIVERSITY OF CAMBRIDGE

TBX4 and the genetics of pulmonary hypertension in children and adults                                                     15:00 - 15:20
Presenter: // Carrie Welch   COLUMBIA UNIVERSITY MEDICAL CENTER, USA & COLUMBIA UNIVERSITY DEPARTMENT OF PEDIATRICS, USA

Histopathology of TBX4 gene mutations                                                                                      15:20 - 15:40
Presenter: // Csaba Galambos     CHILDREN’S HOSPITAL COLORADO & THE UNIVERSITY OF COLORADO, USA

Unraveling the pathogenic mechanisms of developmental lung diseases                                                        15:40 - 16:00
Presenter: // Pawel Stankiewicz    BAYLOR COLLEGE OF MEDICINE, USA

Phenotype and outcome of individuals with pathogenic TBX4 mutations                                                        16:00 - 16:20
Presenter: // David Montani    HÔPITAL BICÊTRE, LE KREMLIN-BICÊTRE, PARIS-SUD UNIVERSITY, FRANCE

TBX4Life: Developing an international family-driven initiative and research focus on TBX4                                  16:20 - 16:40
Presenter: // Anton Morkin    TBX4LIFE INITIATIVE

Q & A period and wrap up                                                                                                   16:40 - 17:00

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Presentations

Webinar 15                                                                                                                                    if not all questions can be answered on the day,

Date // 29 September 2021
                                                                                                                                        all comments will be published and circulated to all
                                                                                                                                                              participants after the webinar.

                                                                                    noTe: Times indicated are british Summer Time (bsT)

beyond DNA:
The unseen genome and novel omics approaches to PH

Chairs & moderators: // micheala aldred inDiana UniversiTy sChooL of meDiCine, Usa
                     // vinicio de Jesus perez sTanforD UniversiTy, Usa
                     // nicholas morrell UniversiTy of CambriDge, UK

Presentations                                                                                                                 15:00-17:00

micrornas and incrnas in right heart hypertrophy and failure                                                                  15:00-15:15
Presenter: // sébastien bonnet LAvAL university, cAnADA
Discussion                                                                                                                    15:15-15:24

Lncrna as biomarkers/therapeutic agents for pulmonary diseases                                                                15:24-15:39
- prospective view
Presenter: // stephen chan university OF Pittsburgh, usA
Discussion                                                                                                                    15:39-15:48

epigenomics in pulmonary vascular remodelling                                                                                 15:48-16:03
Presenter: // soni savai-Pullamsetti mAx PLAnck institute FOr heArt AnD Lung reseArch, germAny
Discussion                                                                                                                    16:03-16:12

multiomic tools for single cell analysis                                                                                      16:12-16:27
Presenter: // Peter smibert neW yOrk genOme centre, usA
Discussion                                                                                                                    16:27-16:36

proteomics: from discovery research toward the clinic - novel ai perspectives?                                                16:36-16:51
Presenter: // christopher rhodes imPeriAL cOLLege LOnDOn, uk
Discussion                                                                                                                    16:51-17:00

                                                                                                                                                                                                  back to
CMe Credits                                                                                                                                                                                      calendar
This event has been accredited by both the european accreditation Council for
Continuing medical education (eaCCme) and the european board for accreditation in            2 CMe credits        2 CMe credits
pneumology (ebap). physicians may convert eaCCme® credits to an equivalent number
of ama pra Category 1 CreditsTm.
16
Presentation

Webinar 16                                                               if not all questions can be answered on the day,

Date // 21 October 2021
                                                                   all comments will be published and circulated to all
                                                                                         participants after the webinar.

                                                                                 noTe: all times indicated are british Summer Time (bsT)

part of the PAH-ICON
Genomics Webinar
Series
15:00 - 17:00

pulmonary veno-occlusive Disease:
genetics and clinical phenotypes
Organisers: // David montani hOPitAux universitAires, PAris-suD,
             FrAnce
           // greg elliot university OF utAh, usA

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Presentations

Webinar 17                                                                                                                                    if not all questions can be answered on the day,

Date // 27 October 2021
                                                                                                                                        all comments will be published and circulated to all
                                                                                                                                                              participants after the webinar.

                                                                                    noTe: Times indicated are british Summer Time (bsT)

Joint symposium with the ISHLT:
end-stage PAH - how and what do we do in 2021?
Chairs & moderators: // paul Corris UniversiTy of newCasTLe, UK
                     // mardi gomberg-maitland gw UniversiTy meDiCine anD heaLTh sCienCes, Usa
                     // walter Klepetko meDiCaL UniversiTy of vienna, aUsTria

Presentations                                                                                                                 15:00-17:00

when should a ph patient be considered for lung transplant?                                                                   15:00-15:15
Presenter: // John granton tOrOntO generAL hOsPitAL, cAnADA
Discussion                                                                                                                    15:15-15:24

atrial septum defect creation or mechanical support for end-stage pah                                                         15:24-15:39
Presenter: // erika berman-rosenzweig cOLumbiA university meDicAL center, usA
Discussion                                                                                                                    15:39-15:48

Lung and heart-lung transplant in 2021: how well do pah patients do?                                                          15:48-16:03
Presenter: // eugene golts university OF cALiFOrniA sAn DiegO, usA
Discussion                                                                                                                    16:03-16:12

pluripotent stem cell-based approaches and the future of artificial lungs                                                      16:12-16:27
Presenter: // ulrich martin hAnnOver meDicAL schOOL, germAny
Discussion                                                                                                                    16:27-16:36

Timing and extent of ventricular reverse remodelling after lung transplant                                                    16:36-16:51
for ph
Presenter: // ryan tedford meDicAL university OF sOuth cArOLinA (musc), usA
Discussion                                                                                                                    16:51-17:00

                     supported by

                                                                                                                                                                                                  back to
CMe Credits                                                                                                                                                                                      calendar
This event has been accredited by both the european accreditation Council for
Continuing medical education (eaCCme) and the european board for accreditation in            2 CMe credits        2 CMe credits
pneumology (ebap). physicians may convert eaCCme® credits to an equivalent number
of ama pra Category 1 CreditsTm.
18
Presentation

Webinar 18                                                            if not all questions can be answered on the day,

Date // 15 November 2021
                                                                all comments will be published and circulated to all
                                                                                      participants after the webinar.

                                                                            noTe: all times indicated are Greenwich Mean Time (gmT)

part of the PAH-ICON
Genomics Webinar
Series
15:00 - 17:00

The genetics of scleroderma-associated pah and
vasoresponders
Organiser: // Ankit Desai inDiAnA university, usA
           // Paul hassoun JOhns hOPkins university schOOL OF
            meDicine, usA

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Presentations

Webinar 19                                                                                                                                if not all questions can be answered on the day,

Date // 24 November 2021
                                                                                                                                    all comments will be published and circulated to all
                                                                                                                                                          participants after the webinar.

                                                                            noTe: all times indicated are Greenwich Mean Time (gmT)

Machine learning and artificial intelligence approaches for PH:
From screening to novel drug targets
Chairs & moderators: // raymond benza ohio sTaTe UniversiTy, Usa
                     // mark gladwin UniversiTy of piTTsbUrg meDiCaL CenTer, Usa
                     // martin wilkins imperiaL CoLLege LonDon, UK

Presentations                                                                                                             15:00-17:00

Looking beyond the hype: applied ai and machine learning in translational                                                 15:00-15:15
medicine
Presenter: // Dennis Wang university OF sheFFieLD, uk
Discussion                                                                                                                15:15-15:22

Computational network pharmacology in cardiovascular disease: Leveraging                                                  15:22-15:37
big data
Presenter: // Joseph Loscalzo hArvArD university, usA
Discussion                                                                                                                15:37-15:45

Drug discovery using artificial intelligence engines: Challenges and opportunities                                         15:45-16:00
Presenter: // tbc
Discussion                                                                                                                16:00-16:08

Utilising artificial intelligence to screen and diagnose ipah                                                              16:08-16:23
Presenter: // David kiely university OF sheFFieLD, uk
Discussion                                                                                                                16:23-16:30

best abstract: biological heterogeneity in idiopathic pulmonary arterial hypertension                                     16:30-16:40
identified through unsupervised transcriptomic profiling of whole blood
Presenter: // sokratis kariotis university OF sheFFieLD, uk
Discussion                                                                                                                16:40-16:45

best abstract: Transcriptomic characterization of pulmonary arterial hypertension                                         16:45-16:55
on pathway level
Presenter: // yajing Ji PhArmAcOLOgy AnD tOxicOLOgy DePArtment,michigAn stAte university, usA
Discussion                                                                                                                16:55-17:00

                                                                                                                                                                                              back to
CMe Credits                                                                                                                                                                                  calendar
This event has been accredited by both the european accreditation Council for
Continuing medical education (eaCCme) and the european board for accreditation in         2 CMe credits       2 CMe credits
pneumology (ebap). physicians may convert eaCCme® credits to an equivalent number
of ama pra Category 1 CreditsTm.
Presentations

Webinar 20                                                                                                                   if not all questions can be answered on the day,

Date // 15 December 2021
                                                                                                                       all comments will be published and circulated to all
                                                                                                                                             participants after the webinar.

                                                                 noTe: all times indicated are Greenwich Mean Time (gmT)

PRO-CON debate session 2:
Medical vs. surgical or interventional therapy for CTePH
Chairs & moderators: // irene Lang meDiCaL UniversiTy of vienna, aUsTria
                     // bradley maron brigham anD women's hospiTaL, harvarD meDiCaL sChooL, Usa
                     // belinda rivera-Lebron The UniversiTy of piTTsbUrgh meDiCaL CenTer, Usa
                     // gérald simonneau UniversiTé paris-saCLay, franCe

Presentations                                                                                             15:00-17:00

PRO: riociguat should be given to all CTeph patients, regardless of timing of pea/bpa                     15:00-15:15
Presenter: // Ardeschir ghofrani Justus-Liebig university OF giessen, germAny
rebuttal                                                                                                   15:30-15:35
CON: riociguat should be given only to patients with inoperable or residual                               15:15-15:30
CTeph after pea/bpa
Presenter: // hiromi matsubara OkAyAmA meDicAL center, JAPAn
rebuttal                                                                                                   15:35-15:40
general discussion                                                                                         15:40-16:00
best abstract: systematic follow-up of patients following acute pulmonary                                 16:05-16:10
embolism is associated with an increased incidence of Chronic Thromboembolic
pulmonary hypertension and less severe disease
Presenter: // charlotte Durrington sheFFieLD PuLmOnAry vAscuLAr DiseAse unit, uk
Discussion                                                                                                 16:10-16:15
best abstract: women and chronic thromboembolic pulmonary hypertension.                                   16:15-16:20
The special meaning of balloon pulmonary angioplasty
Presenter: // Alejandro cruz utrilla cArDiOLOgy DePArtment, university hOsPitAL, mADriD, sPAin
Discussion                                                                                                 16:20-16:25
best abstract: g protein-coupled receptor expression from single cell rna                                 16:25-16:30
sequencing in chronic thromboembolic pulmonary hypertension
Presenter: // gayathri viswanathan DePArtment OF cArDiOLOgy, Duke university meDicAL center, usA
Discussion                                                                                                 16:30-16:35
best abstract: study of the antifibrotic action of JaK inhibitors for the prevention                       16:35-16:40
and treatment of chronic thromboembolic pulmonary hypertension
Presenter: // Andrei karpov ALmAzOv nAtiOnAL meDicAL reseArch centre, russiA
Discussion                                                                                                 16:40-16:45
best abstract: Unilateral Chronic Thromboembolic pulmonary Disease:                                       16:45-16:50
Do they benefit from surgery?                                                                                                        CMe Credits
Presenter: // Farid rashidi tAbriz university OF meDicAL sciences, irAn                                                             This event has been accredited by both the european accreditation Council for
                                                                                                                                                                                                                                                         back to
Discussion                                                                                                 16:50-16:55
                                                                                                                                    Continuing medical education (eaCCme) and the european board for accreditation in   2 CMe credits   2 CMe credits
                                                                                                                                    pneumology (ebap). physicians may convert eaCCme® credits to an equivalent number                                   calendar
                                                                                                                                    of ama pra Category 1 CreditsTm.
Presentations

Webinar 21                                                                                                                     if not all questions can be answered on the day,

Date // 26 January 2022
                                                                                                                         all comments will be published and circulated to all
                                                                                                                                               participants after the webinar.

                                                                  noTe: all times indicated are Greenwich Mean Time (gmT)

Virtual poster discussion session 2                                                                                                   Round 2 - CLINICAL                                                       16:10-17:10
                                                                                                                                      Chairs & moderators: // Joan-albert barbérà
                                                                                                                                                                    hospiTaL CLiniC De barCeLona, spain

Presentations                                                                                                  15:00-17:10                                       // bradley maron
                                                                                                                                                                    brigham anD women's hospiTaL, harvarD meDiCaL sChooL, Usa
                                                                                                                                                                 // victor Tapson
Round 1 - bASIC                                                                                                15:00-16:10                                          CeDars-sinai meDiCaL CenTer CaLifornia, Usa
Chairs & moderators: // peter Dorfmüller JUsTUs-Liebig UniversiTy giessen, germany
                     // max gassmann UniversiTy of zUriCh, swiTzerLanD
                     // mark geraci UniversiTy of piTTsbUrg, Usa                                                                      poster 1: association between Leflunomide and pulmonary hypertension                                                16:10-16:15
                                                                                                                                      Presenter: // thomas Lacoste Palasset PAris-sAcLAy university, FrAnce
poster 1: novel Traf2 variant and KDr deletion are implicated in the                                           15:00-15:05            Discussion                                                                                                         16:15-16:20
pathogenesis of pulmonary arterial hypertension
Presenter: // Jair tenorio LA PAz university hOsPitAL, sPAin                                                                          poster 2: The estimand framework in pah Clinical Trials                                                            16:20-16:25
Discussion                                                                                                     15:05-15:10            Presenter: // youlan rao uniteD therAPeutics cOrP, usA

poster 2: gp130 signaling promotes right ventricular Dysfunction in pulmonary                                  15:10-15:15            Discussion                                                                                                         16:25-16:30
arterial hypertension via microtubules
Presenter: // sasha Prisco   cArDiOvAscuLAr DivisiOn, LiLLehei heArt institute, university OF minnesOtA, usA                          poster 3: risk stratification in pulmonary hypertension due to chronic obstructive                                  16:30-16:35
Discussion                                                                                                     15:15-15:20            pulmonary disease
                                                                                                                                      Presenter: // Athiththan yogeswaran Justus-Liebig-university giessen, germAny
poster 3: Loss of estrogen receptor alpha (erα) worsens hemodynamic                                            15:20-15:25            Discussion                                                                                                         16:35-16:40
alterations and right ventricular (rv) adaptation in female rats with pulmonary
hypertension (ph)
                                                                                                                                      poster 4: small pulmonary vessels in severe pulmonary hypertension associated                                      16:40-16:45
Presenter: // Andrea Frump inDiAnA university schOOL OF meDicine, usA
                                                                                                                                      with chronic lung disease
Discussion                                                                                                     15:25-15:30            Presenter: // Dheyaa Alkhanfar university OF sheFFieLD, uk
poster 4: breast cancer and heritable pah due to bmpr2 mutation:                                               15:30-15:35            Discussion                                                                                                         16:45-16:50
an unexpected discovery
Presenter: // victoria toro quebec university institute OF cArDiOLOgy AnD PneumOLOgy, cAnADA                                          poster 5: a phase 1, open-label, crossover study of inhaled seralutinib to assess                                  16:50-16:55
Discussion                                                                                                     15:35-15:40            potential effects on the pharmacokinetics (pK) of cytochrome p450 (Cyp) and
                                                                                                                                      transporter substrates in healthy subjects
poster 5: smooth muscle Tsc2 deficiency leads to spontaneous pulmonary                                          15:40-15:45            Presenter: // Jack Li gOssAmer biO, inc., sAn DiegO, usA
hypertension and represents attractive molecular target for therapeutic intervention
                                                                                                                                      Discussion                                                                                                         16:55-17:00
Presenter: // steven yuanjun shen schOOL OF meDicine, university OF cALiFOrniA, DAvis, usA
Discussion                                                                                                     15:45-15:50            poster 6: Cardiac mri and risk stratification in pulmonary arterial hypertension:
poster 6: identification of aDora1-pDe10a Complex formation and its                                             15:50-15:55            evaluation of esC/ers thresholds for right atrial area                                                             17:00-17:05
bidirectional regulation of intracellular Cyclic amp Levels as a novel Therapeutic                                                    Presenter: // Faisal Alandejani university OF sheFFieLD, uk
Presenter: // chanil valasarajan mAx-PLAnck-institute FOr heArt AnD Lung reseArch, germAny                                            Discussion                                                                                                         17:05-17:10
Discussion                                                                                                     15:45-15:50
poster 7: Downregulation of adenylate kinase 4 (aK4) improves the mitochondrial                                16:00-16:05
respiration and inhibits the glycolytic switch of pulmonary arterial smooth muscle cells                                              CMe Credits

Presenter: // tessa Wilke Justus-Liebig university giessen, germAny
                                                                                                                                      This event has been accredited by both the european accreditation Council for
                                                                                                                                      Continuing medical education (eaCCme) and the european board for accreditation in
                                                                                                                                                                                                                                                                        back to
                                                                                                                                                                                                                             2 CMe credits   2 CMe credits
                                                                                                                                                                                                                                                                       calendar
Discussion                                                                                                     16:05-16:10
                                                                                                                                      pneumology (ebap). physicians may convert eaCCme® credits to an equivalent number
                                                                                                                                      of ama pra Category 1 CreditsTm.
Presentations

Webinar 22                                                                                                                                if not all questions can be answered on the day,

Date // 23 February 2022
                                                                                                                                    all comments will be published and circulated to all
                                                                                                                                                          participants after the webinar.

                                                                            noTe: all times indicated are Greenwich Mean Time (gmT)

bone marrow modulation of pulmonary vascular disease
Chairs & moderators: // James Klinger brown UniversiTy, Usa
                     // edda spiekerkoetter sTanforD UniversiTy, Usa
                     // rebecca vanderpool UniversiTy of arizona CoLLege of meDiCine, Usa

Presentations                                                                                                             15:00-17:00

role of bone marrow in the pathogenesis of pah                                                                            15:00-15:15
Presenter: // tbc
Discussion                                                                                                                15:15-15:24

role of bone marrow in the right ventricle remodelling                                                                    15:24-15:39
Presenter: // gaurav choudhary PrOviDence vA meDicAL center, usA
Discussion                                                                                                                15:39-15:48

reversal of ph by whole bone marrow transplantation in bmpr2 deficient mice                                                15:48-16:03
Presenter: // James West vAnDerbiLt university meDicAL center, usA
Discussion                                                                                                                16:03-16:12

bone marrow dependency of cigarette smoke-induced ph versus emphysema                                                     16:12-16:27
Presenter: // norbert Weissmann Justus-Liebig university OF giessen, germAny
Discussion                                                                                                                16:27-16:36

homologous bone marrow transplantation prevents the development of pah                                                    16:36-16:51
in patients with severe scleroderma
Presenter: // Jason Weatherald university OF cALgAry, cAnADA
Discussion                                                                                                                16:51-17:00

                                                                                                                                                                                              back to
CMe Credits                                                                                                                                                                                  calendar
This event has been accredited by both the european accreditation Council for
Continuing medical education (eaCCme) and the european board for accreditation in         2 CMe credits       2 CMe credits
pneumology (ebap). physicians may convert eaCCme® credits to an equivalent number
of ama pra Category 1 CreditsTm.
Presentations

Webinar 23                                                                                                                                    if not all questions can be answered on the day,

Date // 30 March 2022
                                                                                                                                        all comments will be published and circulated to all
                                                                                                                                                              participants after the webinar.

                                                                                    noTe: Times indicated are british Summer Time (bsT)

Ageing and pulmonary hypertension:
An endemic at the horizon?

Chairs & moderators: // John newman vanDerbiLT UniversiTy meDiCaL CenTer, Usa
                     // paul williams CenTre for ChesT Disease anD CriTiCaL Care, soUTh afriCa
                     // TbC

Presentations                                                                                                                 15:00-17:00

age-dependent prevalence of ph in the general population                                                                      15:00-15:15
Presenter: // harm Jan bogaard vu university meDicAL center AmsterDAm, the netherLAnDs
Discussion                                                                                                                    15:15-15:22

senescence mechanisms and pulmonary vascular aging                                                                            15:22-15.37
Presenter: // serge Adnot henri mOnDOr hOsPitAL, FrAnce
Discussion                                                                                                                    15:37-15:45

metabolic syndrome and obesity leads to age-related ph                                                                        15:45-16:00
Presenter: // imad Al ghouleh university OF Pittsburgh, usA
Discussion                                                                                                                    16:00-16:08

genetics and epigenetics in age-related ph                                                                                    16:08-16:23
Presenter: // stephen Archer queen's university, cAnADA
Discussion                                                                                                                    16:23-16:30

best abstract: right heart catheterization is underused in elderly patients                                                   16:30-16:50
suspected of pulmonary hypertension
Presenter: // samara Jansen AmsterDAm umc, netherLAnDs
Discussion                                                                                                                    16:50-17:00

                                                                                                                                                                                                  back to
CMe Credits                                                                                                                                                                                      calendar
This event has been accredited by both the european accreditation Council for
Continuing medical education (eaCCme) and the european board for accreditation in            2 CMe credits        2 CMe credits
pneumology (ebap). physicians may convert eaCCme® credits to an equivalent number
of ama pra Category 1 CreditsTm.
Presentations

Webinar 24                                                                                                                                    if not all questions can be answered on the day,

Date // 27 April 2022
                                                                                                                                        all comments will be published and circulated to all
                                                                                                                                                              participants after the webinar.

                                                                                    noTe: Times indicated are british Summer Time (bsT)

The association between cancer and PH:
A tale of two diseases

Chairs & moderators: // elena goncharova UniversiTy of piTTsbUrgh, Usa
                     // Qadar pasha asian-paCifiC soCieTy for moUnTain meDiCine, inDia
                     // marlene rabinovitch sTanforD UniversiTy, Usa

Presentations                                                                                                                 15:00-17:00

Cancer induced ph: embolism as a major inducer                                                                                15:00-15:15
Presenter: // tbc
Discussion                                                                                                                    15:15-15:22

Cancer induced ph: microenvironmental cancer niche as a major inducer                                                         15:22-15:37
Presenter: // rajkumar savai mAx PLAnck institute FOr heArt AnD Lung reseArch, germAny
Discussion                                                                                                                    15:37-15:45

Cancer therapies induced ph                                                                                                   15:45-16:00
Presenter: // Frédéric Perros université PAris-suD, FrAnce
Discussion                                                                                                                    16:00-16:08

Cancer related signalling mechanisms underlying ph development                                                                16:08-16:23
Presenter: // Olivier boucherat LAvAL university, cAnADA
Discussion                                                                                                                    16:23-16:30

best abstract: foxo3: a new potential therapeutic target in pulmonary arterial                                                16:30-16:40
hypertension
Presenter: // yann grobs LAvAL university, cAnADA
Discussion                                                                                                                    16:40-16:45

best abstract: non-invasive surrogate markers of ph are associated with poor                                                  16:45-16:55
survival in lung cancer patients
Presenter: // michael cekay Justus-Liebig university giessen, germAny
Discussion                                                                                                                    16:55-17:00

                                                                                                                                                                                                  back to
CMe Credits                                                                                                                                                                                      calendar
This event has been accredited by both the european accreditation Council for
Continuing medical education (eaCCme) and the european board for accreditation in            2 CMe credits        2 CMe credits
pneumology (ebap). physicians may convert eaCCme® credits to an equivalent number
of ama pra Category 1 CreditsTm.
Presentations

Webinar 25                                                                                                                                    if not all questions can be answered on the day,

Date // 25 May 2022
                                                                                                                                        all comments will be published and circulated to all
                                                                                                                                                              participants after the webinar.

                                                                                    noTe: Times indicated are british Summer Time (bsT)

Professor Sheila Glennis Haworth Memorial Symposium
on Paediatric PH
Chairs & moderators: // mandy maclean mbe, sTraThCLyDe insTiTUTe of pharmaCy anD biomeDiCaL sCienCes, UK
                     // shahin moledina greaT ormonD sTreeT hospiTaL, UK
                     // anita saxena aLL inDia insTiTUTe of meDiCaL sCienCes, inDia

Presentations                                                                                                                 15:00-17:00

genetics of pulmonary arterial hypertension: what we can learn by studying                                                    15:00-15:15
children with and without congenital heart disease
Presenter: // Wendy chung university OF cOLumbiA, usA
Discussion                                                                                                                    15:15-15:22

Therapeutic options in advanced pvD: potts shunt versus lung transplantation                                                  15:22-15:37
Presenter: // mark grady WAshingtOn university schOOL OF meDicine in st. LOuis, usA
Discussion                                                                                                                    15:37-15:45

stem cells and regenerative medicine for neonatal lung disease: implications                                                  15:45-16:00
for CopD
Presenter: // bernard thebaud the OttOWA hOsPitAL, cAnADA
Discussion                                                                                                                    16:00-16:08

assessment of operability in patients with congenital heart disease and pah:                                                  16:08-16:23
fallacies and pitfalls
Presenter: // erika b rosenzweig cOLumbiA university meDicAL center, usA
Discussion                                                                                                                    16:23-16:30

best abstract: The impact of chronic pulmonary hypertension on ventricular                                                    16:30-16:40
function in extremely premature infants
Presenter: // gabriela de carvalho nunes mcgiLL university heALth centre, mOntreAL chiLDren’s hOsPitAL, cAnADA
Discussion                                                                                                                    16:40-16:45

best abstract: improving guidance for the correctability of congenital cardiovascular                                         16:45-16:55
shunts with increased pulmonary vascular resistance
Presenter: // ronald Day university OF utAh, DePArtment OF PeDiAtrics, usA
Discussion                                                                                                                    16:55-17:00

                                                                                                                                                                                                  back to
CMe Credits                                                                                                                                                                                      calendar
This event has been accredited by both the european accreditation Council for
Continuing medical education (eaCCme) and the european board for accreditation in            2 CMe credits        2 CMe credits
pneumology (ebap). physicians may convert eaCCme® credits to an equivalent number
of ama pra Category 1 CreditsTm.
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                                                                                       Pulmonary Vascular
                                                                                        Research Institute

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                            The pvri is a registered Charity in the UK, no: 1127115. Disclaimer: This programme and its contents are correct at the time of printing.
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