Washington University Record, December 10, 2004
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Washington University School of Medicine Digital Commons@Becker Washington University Record Washington University Publications 12-10-2004 Washington University Record, December 10, 2004 Follow this and additional works at: http://digitalcommons.wustl.edu/record Recommended Citation "Washington University Record, December 10, 2004" (2004). Washington University Record. Book 1023. http://digitalcommons.wustl.edu/record/1023 This Article is brought to you for free and open access by the Washington University Publications at Digital Commons@Becker. It has been accepted for inclusion in Washington University Record by an authorized administrator of Digital Commons@Becker. For more information, please contact engeszer@wustl.edu.
Medical News: Heart responds to
fasting by remodeling mitochondria
ovations! New York-based Galumpha j"
to perform at Edison Theatre Jan. 15 O
Washington People: Barton Hamilton
relishes the entrepreneurship process 8
Dec. 10, 2004 Volume 29 No. 17
Washington University in StlDuis
Scientists grow
norovirus in lab
In a study
Is common cause published in
November in
of food poisoning the online jour-
nal Public
BY MICHAEL C. PURDY Library of
Science-Biology,
School of Medicine scientists scientists who
have become the first to suc- developed the
cessfully grow a norovirus in Virgin new technique
the lab. reported it may
In humans, noroviruses are a already have led them to a good
highly contagious source of diar- target for vaccine development.
rhea, vomiting and other stomach "By looking at the mouse virus
ailments that made headlines two we'd grown in the lab, we were
years ago after a series of repeated able to identify a part of the cap-
outbreaks on cruise ships. These sid, the virus' protein shell, that is
viruses are a major cause of hu- essential to its ability to cause dis-
man disease worldwide. ease," said senior author Herbert
Researchers showed that the W. "Skip" Virgin, M.D., Ph.D.,
mouse norovirus MNV-1 could be professor of pathology and im-
grown inside cells from mice with munology and of molecular mi- Campaign Celebration Chancellor Mark S. Wrighton receives a standing ovation as he pre-
defective immune systems. Their crobiology. "If this part of the pares to address the hundreds who gathered Dec. 3 at the Renaissance Grand Hotel in downtown
findings make it much easier to capsid has an equivalent in hu- St. Louis for a gala celebration marking the success of the Campaign for Washington University.
learn about the mouse virus and man noroviruses, altering or dis- Attendees were treated to an evening of food, presentations and music and dancing with the Steve
may help other researchers seeking abling it may give us a way to pro- Schankman Orchestra. The campaign, the fund-raising initiative launched to secure the resources
to duplicate the accomplishment duce forms of the viruses that are needed to realize the University's potential for the good of generations to come, ended June 30 with
with human forms of the virus. See Lab, Page 6 $1.55 billion in gifts and commitments and a record 165 new endowed professorships.
Mental-health MetroLink project moves
center earns
advanced toward 2006 completion
BY ANDY CLENDENNEN pedestrian bridge. Concrete work
designation Just like the little engine —
will also continue at the tunnel
west of DeBaliviere Avenue.
or mass transit train — that At the two other new stations
BY JESSICA MARTIN
could, the MetroLink cross-coun- adjacent to University campuses
ty expansion just keeps on chug- — the University City/Big Bend
The Center for Mental Health
ging along. Boulevard and Forsyth stations,
Services Research (CMHSR) in
And December should bring concrete work will continue, and
the George Warren Brown School
more of the same as Metro chugs shoring and excavation work will
of Social Work has received fund-
toward an anticipated project- continue for a tunnel between Big
ing from the National Institute of
completion date in mid-2006. Bend and Kingsland Avenue.
Mental Health (NIMH) to be-
Mass excavation efforts will Concrete work will continue in
come the nation's first Advanced
continue at the Skinker Avenue the tunnel between Big Bend and
Center for Interventions and Ser-
station at the intersection of Skin- Pershing Avenue.
vices Research at a school of
ker and Forest Park Parkway. As with any major construc-
social work.
Concrete work is scheduled to tion endeavors, minor side irrita-
CMHSR will celebrate its new
begin at the Skinker tunnel. tions will pop up once in a while.
designation and expanded re-
As viewed looking north, at Forest Park Parkway just east of Big Construction of the station Again, the same holds true for the
search agenda during an opening
Bend Boulevard, construction crews work on a new MetroLink sta- entrance, at the southwest corner coming months.
and reception from 1-2:30 p.m.
tion. Metro is anticipating that the cross-county expansion project of that intersection, will continue, The pedestrian crossing of
Jan. 11 in the Brown Hall Lounge.
will be finished in mid-2006. as well as substructure work for a See MetroLink, Page 2
Visitors can hear about the cen-
ter's current and future research
from CMHSR leaders.
"We are proud and excited to Mother Nature's nuclear reactor Olin Cup entrepreneurship contest
have received support for this
next, more ambitious phase of
our research," said Enola K. Proc-
described by WUSTL researchers winners named; Luminomics is 1st
tor, Ph.D., center director and the BY TONY FITZPATRICK Analyzing a fragment of Ga- In this year's Olin Cup entre- An honorable mention was
Frank J. Bruno Professor of Social bon-site rock that's less than one- Ipreneurship
t competition, the given to Core Devices, maker of
Work Research. To operate a nuclear power eighth of an inch, Alexander Me- Olin School of Business has a portable anesthesia machine.
"This advanced center pro- plant like Three Mile Island, shik, Ph.D., senior research scien- awarded a total of $70,000 in "We've created an open,
vides critical core support to our hundreds of highly trained em- tist in the Department of Physics seed investment capital to two inclusive environment for team
faculty as they test new ways to ployees must work in concert to in Arts & Sciences, has calculated startup businesses. formation," said Kenneth A.
meet the mental health needs of generate power from safe fission, that the precise isotopic structure The awards were announced Harrington, managing director
the most vulnerable members of all the while containing danger- of xenon in the sample reveals Dec. 2 at a reception in Simon of the Skandalaris Center for
our society — those served by ous nuclear wastes. an operation that worked like a Hall. Entrepreneurial Studies, which
publicly funded social service On the other hand, it's been geyser. The reactor, active 2 bil- The Olin Cup for first place, sponsors the competition. "A
agencies. Finding out how to im- known for 30 years that Mother lion years ago, worked on a 30- along with $50,000 in seed business startup idea can be
prove the quality of their mental Nature once did nuclear chain minute reaction cycle, accompa- money, went to Luminomics, a submitted from anywhere in
See Center, Page 6 reactions by her lonesome. nied by a 2.5-hour dormant peri- biotechnology company that the University or community,
Now, University researchers od, or cool-down. develops regenerative drug ther- and funding will be made avail-
Happy holidays! have analyzed the isotopic struc- In a recent issue of Physical apies for degenerative diseases. able to teams having only one
ture of noble gases produced in Review Letters, Meshik and his An award of $20,000 went to Olin student or recent alumnus
The Record will not be pub- fission in a sample from the only University collaborators wrote: The Blessing Basket, a not-for- on the team.
known natural nuclear chain re- "This similarity (to a geyser) profit company that imports "But we are also actively
lished again until Jan. 21. We
action site in the world in Gabon, suggests that a half an hour after baskets made by weavers in searching for sponsors and cor-
hope you and your family have
a wonderful holiday season. West Africa, and have found how the onset of the chain reaction, undeveloped countries. See Olin, Page 6
she does the trick. See Reactor, Page 6
WASHINGTON UNIVERSITY MEDICAL LIBRARY
3 2201 20337 20202 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS
Law dean advisory
committee named
BY ANDY CLENDENNEN dean of admissions and financial
aid in the School of Law; Michael
Chancellor Mark S. Wrighton R. Cannon, J.D., executive vice
has appointed an advisory chancellor and general counsel;
committee to assist him in Glenn L. Dalton, president of
the search for the next dean of the the RKD Group; Rebecca S. Dres-
School of Law. ser, J.D, the Daniel Noyes Kirby
Joel D. Seligman, J.D., dean of Professor of Law; Jean C. Hamil-
the School of Law and the Ethan ton, chief judge, U.S. District Court,
A.H. Shepley University Professor, Eastern District of Missouri, and a
announced recendy that he would member of the law school's nation-
be leaving Washington University al council; Edward F. Lawlor, Ph.D.,
to become president of the Uni- dean of the George Warren Brown
versity of Rochester. He is sched- School of Social Work; Stephen H.
uled to step down here June 30. Legomsky, J.D, D.Phil., the Charles
The Advisory Committee on F. Nagel Professor of International
the Appointment of the Dean of and Comparative Law;
the School of Law is charged with Ned O. Lemkemeier, J.D., mem-
identifying 3-5 individuals with ber of the Board of Trustees, part-
the intellectual, administrative, ner with Bryan Cave LLP, and
personal and leadership qualities chair of the law school's national
sought for the new dean, said council; Sasha E. Polonsky, student
Wrighton, who hopes to complete in the School of Law; Nancy C.
the appointment process by July 1. Staudt, J.D., professor of law; and
Wrighton has named Daniel L. William H. Webster, member of
Thomas distinguished professorship Edward S. Macias, Ph.D. (center), executive vice Keating, J.D., the Tyrell Williams the Board of Trustees and the law
chancellor and dean of Arts & Sciences, was installed as the inaugural Barbara and David
Professor of Law and dean for school's national council and sen-
Thomas Distinguished Professor in Arts & Sciences in a ceremony Dec. 1 in the Arts & Sciences
Laboratory Science Building. Chatting with Macias and his wife, Tedi, at the event Is John F. academic affairs, to chair the ior partner with Milbank, Tweed,
McDonnell, retired chairman of the board of McDonnell Douglas Corp. and vice chairman of the committee. Hadley 8c McCloy LLP.
University's Board of Trustees. In nearly 35 years at the University, Macias has served in numer- Other committee members The University has hired a con-
ous roles, including University provost, chair of the Department of Chemistry in Arts & Sciences are: Jane Harris Aiken, J.D., the sultant to assist in the search
and director of the Summer School. William M. Van Cleve Professor process; he is Jerry H. Baker of
of Law; Janet L. Bolin, associate Baker-Parker Inc. in Adanta.
Detjen named University trustee Martin Luther King's legacy
David W. Detjen, J.D., a partner
in the New York office of Al-
Professor of Biochemistry at
Technion-Israel Institute of
undergraduate life, audit, medical
finance, university finance, and
honored via campus events
ston & Bird LLP and co-chair of Technology, has been a visiting the Alumni Board of Governors. BY NEIL SCHOENHERR open to the public. For more
the law firm's New York interna- professor of pediatrics in the information, call 935-5970.
tional group, was named a mem- WUSTL School of Medicine About David W. Detjen £ i T%e the Change" is the
ber of the University's Board of since 1987. Detjen, in addition to his role Dtheme of the University's Other MLK events
Trustees at its Dec. 3 meeting. Wrighton reported that appli- with Alston & Bird, is executive annual celebration honoring Among other campus events is
The announcement was made cations for the fall 2005 freshman editor of the International Law Martin Luther King Jr. at 7 p.m. the Black Law Students As-
by Chancellor Mark S. Wrighton. class are strong and currendy are Practicum, a publication of the Jan. 17 in Graham Chapel. sociation's annual Martin Lu-
At the meeting, trustees heard ahead of last year, as are applica- New York State Bar Association, Chancellor Mark S. ther King Jr. commemorative
a presentation on career planning tions for early decision students. and several books ranging from Wrighton will begin the pro- speaker event.
and placement by James E. Mc- Campus visits by high-school sen- how to arrange joint ventures gram with a welcome and Susan R. Jones, professor
Leod, vice chancellor for students iors are up, a good sign of contin- with international partners to The remarks. The evening will of clinical law and supervising
and dean of the College of Arts & uing interest in the University. Germans in Missouri, 1900-1918: include performances by Va- attorney of the Small Business
Sciences, and John A. Berg, associ- Noted were the recent installa- Prohibition, Neutrality, and shon High School's drum line, Clinic at George Washington
ate vice chancellor for undergrad- tions of four faculty members to Assimilation, published in 1985. the YMCA Boys Choir, the University, will present "Dr.
uate admissions. Their report endowed professorships created Detjen is a member of the University's Vision Gospel Martin Luther King Jr.'s Legacy:
dealt with the importance of ca- during the just-completed Cam- American Bar Association, the Choir and Black Anthology, An Economic Justice Impera-
reer planning to students and paign for Washington University. New York State Bar Association, as well as testimonials from tive" at 11 a.m. Jan. 19 in An-
their families, as well as strategies Altogether, 165 professorships the Bar Association of Metropoli- University students. heuser-Busch Hall.
and programs being implemented were established during the cam- tan St. Louis, the Association of A reception in the Women's Jones is senior editor and
to continue to provide strong paign. the Bar of the City of New York Building Formal Lounge will past editor in chief of the
service to students during their Wrighton briefed the trus- and the German American Law follow the program. American Bar Association
college years. tees on the appointment of Joel Association. The celebration is spon- Journal ofAffordable Housing
A report on the University's Seligman, J.D., dean of the School A 1970 graduate of Arts 8c sored by Black Anthology, the and Community Development
self-study for the just-completed of Law and the Ethan A.H. Shep- Sciences at WUSTL, Detjen Black Student Council, Bon Law and author of A Legal
North Central Association accred- ley University Professor, as presi- earned a degree from the Appetit, Campus Y, the Cath- Guide to Microenterprise Devel-
itation visit was presented by dent of the University of Roches- University's School of Law in olic Student Union, Corner- opment.
Gerhild Scholz Williams, Ph.D., ter; and on the search for a suc- 1973. He serves as a member of stone, the Disability Resource For more information, call
associate vice chancellor for aca- cessor to Olin School of Business that school's national council, Center, the Office of Greek 935-4958.
demic affairs, chair of the Depart- Dean Stuart I. Greenbaum, and in 1998 he received the Life, the Department of Psy- The Business Minority
ment of Germanic Languages Ph.D., also the Bank of America school's distinguished alumni chology in Arts 8c Sciences, the Council will present a talk
and Literatures, and the Barbara Professor of Managerial Lead- award. Office of Residential Life, the about King's contributions
Schaps Thomas and David M. ership. While a law student, he was Office of Student Activities, toward equality in education
Thomas Professor in the Human- Wrighton gave the trustees an editor in chief of the Washington the Office of Student Affairs, and the workplace and how his
ities; and by James W. Davis, update on discussions regarding University Law Quarterly and was Student Union and the Wesley efforts have affected African-
Ph.D., professor of political sci- the establishment of the Richard elected to the Order of the Coif. Fellowship. Americans in the business
ence. Williams and Davis co- A. Gephardt Institute of Public He also studied law and history at This is the 18th year the world. The event will be at
chaired the coordination of the Affairs, which will continue to the Eberhard-Karls-Universitat in University has supported a 3 p.m. Jan. 22 in Simon Hall.
accreditation visit and the prepa- enhance the University's outreach Tubingen, Germany. King tribute. For more information, call
ration of the detailed self-study. into the community through Alston & Bird has more than The celebration is free and 935-7301.
In his report to the trustees, public service by students and 700 attorneys in five major mar-
Wrighton noted several significant other members of the University kets, representing companies
accomplishments during the past community. such as UPS, Verizon Wireless,
few months, including the selec-
tion of Aaron Ciechanover, M.D.,
The trustees received standing
committee reports on buildings
Bertelsmann AG, Wachovia
Corp., BellSouth Corp., Delta
Campus Watch
D.Sc, to receive the 2004 Nobel and grounds/real estate, develop- Airlines Inc., AFLAC and The
Prize in chemistry. Ciechan- ment, educational policy, Hilltop Prudential Insurance Co. of The following incidents were reported to University Police Dec. 2-8. Readers with informa-
over, the Research Distinguished finance, research-graduate affairs, America. tion that could assist in investigating these incidents are urged to call 935-5555. This infor-
mation is provided as a public service to promote safety awareness and is available on the
University Police Web site at police.wustl.edu.
MetroLink
wood Boulevard in Clayton. The and communications systems that
parkway is scheduled to reopen in will be used for MetroLink opera- Dec. 3 Dec. 6
2005. Motorists are encouraged to tions. 1:45 a.m. — Residential Techno- 3:37 p.m. —A suspicious enve-
Some alleys closed use Interstate 64 (Highway 40) or Residents in that area who logy Services reported a comput- lope postmarked from Algeria
Olive Boulevard as alternate park their cars in their garages er-hacking incident in progress in was received by an occupant of
during construction routes. and need their vehicles during Gregg House. A resident was con- the Angelica building at 700
- from Page 1 Even the alleys of some hous- those days need to have their cars tacted to establish the originator Rosedale Ave. The item was con-
ing units are being impacted. out of the garages before 7 a.m. of the illicit computer action. It is veyed to the University Police
From Dec. 7 and running for These dates and times may believed that this resident wasn't station to conduct a further
Forest Park Parkway at Williams about two weeks, alleys behind change in the case of bad weather the perpetrator, but that the com- investigation, which is con-
Avenue in University City is homes on the south side of Per- or unforeseen conditions. puter connection was being used tinuing.
closed. All pedestrians should use shing, between Williams and the To receive a daily update on as a ghost server for the actual Additionally, University Police
the pedestrian underpass at Wel- east end of the alley, are closed progress of the alley work, contact perpetrator. An investigation is responded to two reports each of
lesley Avenue. from 7 a.m.-5:30 p.m. Jon Soucy with Metro Project continuing. property damage and auto acci-
And Forest Park Parkway is This closure is necessary while Communications at jsoucy@ dent, and one report each of larce-
closed between Union Boulevard Metro's contractor constructs an metrostlouis.org or 982-1400, ny, lost article, disturbance and
in the city of St. Louis and Brent- underground room for signaling ex. 2709. suspicious person.record.wustl.edu WASHINGTON UNIVERSITY IN ST. LOUIS Dec. 10,2004 3
School of Medicine Update
Heart responds to fasting
by remodeling mitochondria
BY GWEN ERICSON more surprising because phos-
pholipids comprise essential com-
School of Medicine researchers ponents of all cellular membranes
have identified a previously and have previously been thought
unsuspected response by mouse to be preserved except in cases of
heart muscle cells to fasting condi- extreme starvation.
tions: the cells' power generators, The researchers' data also re-
the mitochondria, appear to re- veals that after feeding resumes,
model and consume extra internal the phospholipid levels in heart
walls or membranes in an effort muscle cells rise back to normal
to supply energy to the rest of levels, indicating that mitochon-
the cell. dria readily rebuild their mem-
Partially consumed are the spe- branes.
cialized internal membranes mito- During this recovery period,
chondria use to generate energy- another class of lipid, triglyceride,
rich compounds for the cell, mak- a common source of energy for
ing the mitochondrial strategy many types of cells, peaks high
appear to create more problems above its normal level in heart
than it might solve. Nevertheless, muscle cells.
the response appears to help "The rise of triglyceride isn't
maintain healthy heart function easily explained by nutritional
throughout caloric restriction. conditions, because after feeding
"It is likely that the changes in resumes, the heart shouldn't need
the membranes make the mito- to increase its levels of fats," Gross
chondria more energy efficient said. "It's as if the heart retains a
and serve as an adaptation to nu- memory of deprivation and does-
tritional deprivation in mam- n't want to get caught unprepared Check-mate it OUt Second-year medical students Eugenia Garvin (left) and Louise Yeung
mals," said Richard Gross, M.D., again." examine a bronze work by Arts & Sciences anthropology doctoral student Blaine Maley. The piece
Ph.D., senior author and professor The next step for the research was among 30 on display at an art show held Nov. 18 at the Bernard Becker Medical Library's
of medicine and director of the team will be to study the changes King Center. Garvin and Yeung, along with fellow second-year student Yamini Virkud, coordinated
Division of Bioorganic Chemistry in shape and structure of mito- the show, which also included poetry readings, photography, painting, drawing, quilting, pottery
and Molecular Pharmacology in chondria and to relate these to and calligraphy by University students, faculty and staff. The well-attended show raised money
for the Center of Creative Arts' Urban Arts Program In St.- Louis.
the Department of Medicine. changes to lipid metabolism.
The findings, scheduled to be The response by heart mito-
reported in an upcoming issue of chondria might lend a partial
the journal Biochemistry and now
available through advance online
publication, may have implica-
explanation to a pattern discerned
in studies of ischemic heart pa-
tients, who have restricted blood
Research finds differences in gene usage
tions for human cardiovascular
health.
flow to the heart.
"While we have to be careful in dramatically change bacteria's 'lifestyles'
In its studies of mouse heart drawing definitive parallels be-
muscle, the research team found tween mouse lipid dynamics and BY MICHAEL C. PURDY ed to understanding how the bac- into E. coli, the bacteria gained
levels of two members of a class human lipid dynamics, it is inter- teria might use identical genes the ability to resist polymyxin B
of lipids (fatty molecules) called esting to note that the majority of When and where a bacteri- differently. in low magnesium environments.
phospholipids fell dramatically sudden death in ischemic heart um uses its DNA can be as Salmonella and E. coli share Based on data still to be pub-
when food was withheld. For one patients occurs in the early morn- important as what's in the the gene for an antibiotic resist- lished, Groisman suspects that
type of phospholipid, levels de- ing hours when people have typi- DNA, according to School of Me- ance regulatory protein called many other aspects of microbial
creased by 20 percent after only cally had a long fast and are sub- dicine researchers. PmrA. By controlling when other lifestyle are affected by differences
four hours of fasting; and for the ject to a vast array of hormonal Scientists found significant proteins are produced, PmrA can in regulation of identical genes.
other, levels dropped a remarkable influences during the sleep-wake differences in two bacterial or- make the cell wall more resistant He notes that the idea of dif-
40 percent after 12 hours of cycle," Gross said. ganisms' use of a gene linked to to damage from the antibiotic ferent organisms making altered
fasting. "The alterations in heart mus- processes that govern a form of polymyxin B. use of the same genes sprang
The changes in phospholipids cle energy utilization during fast- antibiotic resistance. The distinc- The PmrA protein normally from recent analyses of the hu-
occurred mainly in the mitochon- ing may setup a deleterious situa- tion alters the bacteria's "life- activates in response to high iron man genome.
dria, which are highly abundant in tion in the hearts of ischemic styles," or their ability to survive levels. "Humans not only appear to
heart muscle cells and account for heart patients." in different environments. In a paper recently published have far fewer genes than expect-
most of the phospholipid content The research team uncovered Researchers say the finding in Genes and Development, Grois- ed, there also seem to be fewer
of the cells. Mitochondria serve to the fluctuations in cellular lipids shows that understanding such man's lab established that another genes that are unique to human
break down many types of fats to through an innovative new tech- changes will likely help develop- protein, PmrD, also can activate DNA than anticipated," Grois-
produce the high-energy cellular nology it developed called "shot- ment of new treatments for dis- PmrA in response to low magne- man said.
fuel ATP, which is essential for a gun lipidomics." As the name sug- ease-causing microorganisms. sium levels. In addition to instructions for
multitude of cellular processes, gests, in comparison to other "These differences in gene In the new study, Groisman's building proteins, DNA contains
including the regular contraction techniques, shotgun lipidomics usage are harder to look for, but lab discovered that E. coli has a stretches of code that affect when
of the heart muscle. has the speed and coverage of a we're not going to understand different version of PmrD that is genes are turned on and off. As
"What we measured was a mas- shotgun blast. From a simple one- these organisms fully unless we unable to turn on the PmrA pro- life becomes more complex over
sive change in heart lipid composi- step extraction of lipids in tissues, take into account this other di- tein in response to low magne- the course of evolution, Groisman
tion," Gross said. "In part, it con- the team can obtain in minutes mension," said senior investigator sium. said, these regulatory sections
firms what science has come to rec- highly accurate measurements of Eduardo Groisman, Ph.D., pro- "We're not really sure what the appear to take up larger portions
ognize — mitochondria are quite the various cellular lipids, which fessor of molecular microbiology significance of low magnesium is, of the DNA, allowing genes to be
dynamic and change shape in re- previously have been notoriously and a Howard Hughes Medical but there are some indications turned on and off in ways that are
sponse to nutritional and hormon- fragile, time-consuming to analyze Institute investigator. that it may be important to the more intricately responsive to the
al cues. But we are the first to re- and hard to quantify. The study appeared the week bacteria's ability to survive in environment and other factors.
port that mitochondria essentially ■ "Through the efforts of people of Nov. 29 in the online edition white blood cells or outside of Human DNA, Groisman spec-
remodel their own membranes, in our division like Xianlin Han, of the Proceedings of the National the host in soil or water," Grois- ulated, may be heavily packed
and thereby their physical proper- who has worked hard to perfect Academy of Sciences and in print man said. with the factors that allow a more
ties, by dynamically altering their the technology, we have been able Dec. 7. When scientists transplanted complex, richer use of genes also
use of phospholipids." to open up fresh avenues of inves- One of the bacteria studied, the Salmonella form of PmrD found in other organisms.
A phospholipid decrease of the tigation using shotgun lipido- Salmonella enterica, is a leading
magnitude reported is all the mics," Gross said. cause of food poisoning and ill-
ness related to animal husbandry.
The other, Escherichia coli, can
cause illness but more typically Record (USPS 600-430; ISSN 1043-0520),
Cooper honored by British surgical society plays a beneficial role in the hu-
Founded in 1905
Volume 29, Number 17/Dec, 10,2004.
man digestive system. - Published tor the faculty, staff and friends
The two are closely related ge- Washington University community news of Washington University. Produced weekly
BY GILA Z. RECKESS include leading
the team that netically. Less than 20 percent of Editor Kevin M. Kiley during the school year, except school
E. coli's genes are not found in Associate Editor Andy Clendennen holidays, and monthly during June, July
Joel D. Cooper, M.D., the Evarts performed the Assistant Editor Neil Schoenherr and August by the Office of Public Affairs,
A. Graham Professor of Sur- first successful Salmonella and just over 25 per- Associate Vice Chancellor Judith Jasper Leicht Washington University, Campus Box 1070,
gery and chief of the Division of lung transplant cent of Salmonella's genes lack Executive Editor Susan Killenberg McGinn One Brookings Drive, St. Louis, MO 63130.
Cardiothoracic Surgery, has been in the world in counterparts in E. coli. Medical News Editor Kimberly Leydig Periodicals postage paid at St. Louis, MO.
awarded an honorary fellowship 1983, and then Groisman's research had pre- Production Carl Jacobs
Where to send address changes
of the Royal College of Surgeons leading the first viously focused on how differ- News t Comments
of England, which is internation- successful dou- ences in gene content made Sal- (314) 935-6603 Postmaster and nonemployees Record,
Cooper monella a persistent source of ill- Campus Box 1070 Washington University, Campus Box 1070,
ally recognized as one of the ble lung trans- kiley@wustl.edu One Brookings Drive, St. Louis, M0 63130.
world's leading authorities in plant in 1986. ness. He identified several areas in
Medical News
surgery. He also pioneered a procedure the bacteria's DNA known as Employees Office of Human Resources,
(314)286-0119 Washington University, Campus Box 1184,
Cooper was presented this dis- called lung-volume reduction sur- "pathogenicity islands" — clus- Campus Box 8508
ters of genes unique to Salmonella One Brookings Drive, St. Louis, M0 63130.
tinction in a recent ceremony at gery, in which surgical removal of leydigk@wustl.edu
the Royal College Headquarters the most-damaged portions of that help it cause illness.
in London. the lung dramatically improve When complete gene maps for
Cooper's extensive accom- quality of life for patients with both bacteria became available in IS ^JvfehingtonUniversity in StLouis
plishments in lung surgery severe emphysema. recent years, his interests expand-4 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS
University Events
Callaway, Graae to bring evening of cabaret Jan. 15
BYLIAMOTTEN Grill, for which she received both a Drama Desk Award Off-Broadway shows include Hello Muddah, Hello
nomination and a Drama League Award nomination. Fadduh (for which he received a Drama Desk Nomination),
Between them, singers Liz Callaway and Jason Graae Sibling Revelry, a cabaret show she created with sister, Forever Plaid, Olympus on My Mind, All in the Timing and
boast 11 Broadway shows, more than 65 recordings Ann Hampton Callaway, was recorded live for DRG Re- many more.
and dozens of film and television appearances. cords and won both a Back Stage Bistro Award and a MAC In Los Angeles, he spent a year as Houdini in the U.S.
They also boast a friendship that has survived more Award from the Manhattan Association of Cabarets & premiere of Ragtime, won an Ovation Award for Forbidden
than 20 years of showbiz. (The pair met as cast-mates in a Clubs. Broadway Y2KLA! and was recently nominated for a second
1980 off-Broadway production of Godspell. Callaway was Callaway can be heard on more than 30 recordings, Ovation for the role of Moonface in the revival of Anything
paid $18 per week. St. Louis native Scott Bakula starred as including three solo albums: The Beat Goes On (featuring Goes!
Jesus.) music of the '60s), The Story Goes On: Liz Callaway On and Graae made his opera debut as Njegus in The Merry
At 8 p.m. Jan. 15, Edison Theatre's OVATIONS! Series Off-Broadway and Anywhere I Wander: The Music of Frank Widow with the Los Angeles Opera and his Metropolitan
will present these "musical pals" in Back- Loessor. Opera House debut as vocal soloist in Twyla Tharp's Ever-
stage Broadway Buddies, an intimate She performed the title character's last. He has recorded more than 35 original cast albums
cabaret-style evening of standards and singing voice in the animated feature and studio CDs, including two solo discs, You're Never Fully
stories, solos and duets, gossip and sen- Anastasia, and her song "Journey to the Dressed Without A Smile: Jason Graae Sings Charles Strouse
timent. Past" was nominated for a 1998 Academy and Jason Graae: LIVE At The Cinegrill.
Callaway, who performed at Edison Award. On television, he has been featured as Dennis on HBO's
Theatre in 2002 with Godspell composer Other film work includes the singing Six Feet Under and also appeared on Rude Awakening,
Stephen Schwartz, is a Chicago native and voice of Princess Jasmine in Disney's The Friends, Frasier and Sabrina the Teenage Witch, among
daughter of journalist John Callaway. Return ofjafar and Aladdin and the King many others.
She made her Broadway debut in Callaway Graae
of Thieves as well as vocals for The Swan Graae has been featured twice with the Boston Pops on
Stephen Sondheim's Merrily We Roll Princess, Lion King 2: Simba's Pride, Beauty PBS, and for five years he was the voice of Lucky Charms
Along and has also appeared in The Three and the Beast and The Brave Little Toaster Cereal's Lucky the Leprechaun.
Musketeers; Miss Saigon, for which she originated the role Goes to Mars. Recent film roles include the Disney animated feature
of Ellen; Baby, for which she earned a Tony Award nomi- She received an Emmy Award for hosting Ready To Go, a Home on the Range and the forthcoming On Edge with
nation; and Cats, where she spent five years playing Griz- daily children's program on CBS in Boston. Jason Alexander.
abella. Graae, dubbed "the undoubted master of humorous Tickets — $28; $24 seniors and WUSTL faculty and staff,
In addition to Godspell, Callaway has appeared off- song" by New York Magazine, has starred on Broadway in A $18 for students and children — are available at the Edison
Broadway in The Matinee Kids, 1-2-3-4-5, No Way To Treat Grand Night For Singing, Falsettos, Stardust, Snoopy! and Do Theatre Box Office and through all MetroTix outlets.
a Lady, Brownstone, Marry Me A Little and The Spitfire Black Patent Leather Shoes Really Reflect Upl For more information, call 935-6543.
Blood Drive • How We Sense Infection • Mouse Models
"University Events" lists a portion of
the activities taking place Dec. 10-Jan. 24
at Washington University. Visit the Web for
How to submit
expanded calendars for the Hilltop Campus 'University Events'
(calendar.wustl.edu) and the School of
Medicine (medschool.wustl.edu/ Submit "University Events" items
calendars.html).
to Genevieve Podleski of the
Record staff via:
Exhibits (1) e-mail — recordcalendar
©wustl.edu;
(2) campus mail —
Architecture Exhibition. Soccer field com- Campus Box 1070; or
petition student entries. Through Dec. 20. (3) fax —935-4259.
Givens Hall. 935-6200. Deadline for submissions is
noon on the Thursday eight days
prior to the publication date.
Lectures Series. Basic Research Seminar. Jim
Lederer, dept. of surgery. Harvard U.
Friday, Dec. 10 Clinical Science Research Bldg., Rm.
9:15 a.m. Pediatric Grand Rounds. "Res- 5550. 362-8560.
piratory Viruses for the 21st Century — 4 p.m. Medical Humanities & Social
Three Stories." Gregory Storch, prof, of Science Talk. 'Taking the 'Nox' Out of
pediatrics, of medicine and of molecular Nocumentum: Poisons, Drugs and Side
microbiology. Clopton Aud., 4950 Effects in Thirteenth- and Fourteenth-
Children's Place. 454-6006. century France." Walt Shalick, prof, of
Noon. Cell Biology & Physiology Seminar. history and of pediatrics. Brookings Hall,
"RGS Proteins —Functions and Thera- Rm. 100. 935-5340.
peutic Potential." Richard R. Neubig, prof,
of pharmacology, U. of Mich. McDonnell Wednesday, Dec. 15
Medical Sciences Bldg., Rm. 426.
362-1668. 4 p.m. Biochemistry & Molecular Bio-
physics Seminar. "Beyond Crystallo- Through the perilOUS fight The Concert Choir of Washington University, under the direction
4 p.m. Dept. of Music Lecture. "Onyx Club graphy, Functional Protein Dynamics
Revue: Jazz and White Masculinity in the From Site-directed Spin Labeling."
of John Stewart, director of vocal activities in the Department of Music in Arts & Sciences, per-
Early Swing Era." Patrick Burke, asst. Wayne Hubbell, prof, of chemistry & forms the national anthem before the Dec. 5 NFC battle between the St. Louis Rams and the San
prof, of music. Music Classroom Bldg., biochemistry and of ophthalmology, Francisco 49ers at the Edward Jones Dome. The 80-some members of the choir, which will also
Rm. 102.935-4841. U. of Calif., Los Angeles. Cori Aud., be in concert at 8 p.m. tonight in Graham Chapel, remained to watch the game from the sidelines.
4565 McKinley Ave. 362-0261. The Rams won, 16-6.
Saturday, Dec. 11
8:30 a.m.-3 p.m. Internal Medicine CME Thursday, Dec. 16
Course. "Coding for Physician Services: Thursday, Jan. 6
Noon. Genetics Seminar Series. Monday, Jan. 17
Hospital Setting." Cost: $165 for physi-
cians, $140 for allied health profession-
als. Eric P. Newman Education Center. To
"Algorithmic Improvements in Linkage
Analysis: Modeling Genotyping Error
and Linkage Disequilibrium." Goncalo
Noon. Center for Health Policy Ethnic &
Racial Disparities in Health Care Brown
7 p.m. University Commemoration
Celebration for Martin Luther King Jr.
Music
register: 362-6891. Bag Seminar Series. "Telemedicine to "Be the Change." Graham Chapel.
Abecasis, asst. prof, of biostatistics, U. of
Mich. McDonnell Medical Sciences Bldg.,
Improve Care and Reduce Disparities in 935-5970. Friday, Dec. 10
Rural Missouri." Karen Edison, Center for 8 p.m. Concert. Concert Choir of Washing-
Monday, Dec. 13 Rm. 823.362-2139.
Health Policy, U. of Mo. Simon Hall, Rm.
Noon. CSNSI & Neurology Research Se- 4 p.m. Cell Biology & Physiology Lecture. 241.935-9108. Wednesday, Jan. 19 ton University. John Stewart, dir. Perfor-
mance dedicated to the memory of
minar. Kelvin Yamada, assoc. prof, of Erlanger-Gasser Lecture. "Mouse Models 11 a.m. School of Law "Access to Jus- William R. Kohn, prof, emeritus in the
neurology, asst. prof, of pediatrics. Ma- for Cancer." Anton I.M. Berns, prof., tice" Public Interest Law Speakers
ternity Bldg., Schwartz Aud. 362-9460. Nederlands Kanker Institut, Amsterdam. Monday, Jan. 10 Series. Black Law Students Association
School of Art. Graham Chapel. 935-4841.
McDonnell Medical Sciences Bldg., Rm. 4 p.m. Immunology Research Seminar Martin Luther King Jr. Commemorative
4 p.m. Immunology Research Seminar 426. 362-6812. Series. "Cancer Immunoediting: Mole- Speaker. "Dr. Martin Luther King Jr.'s Monday, Dec. 13
Series. "Poised on a Knife Edge: Balan- cular Mechanisms and Therapeutic Legacy: An Economic Justice Imper-
cing Immunity Versus Virulence During 8 p.m. Concert. Flute Choir. Jan Smith, dir.
Implications." Robert D. Schreiber, ative." Susan R. Jones, prof, of clinical
Chronic Herpesvirus Infection." Herbert Friday, Dec. 17 Alumni Professor of pathology & im- law, George Washington U. Anheuser-
Graham Chapel. 935-4841.
"Skip" Virgin, prof, of pathology & im- 9:15 a.m. Pediatric Grand Rounds. "Hy- munology. Eric P. Newman Education Busch Hall. 935-4958. 8 p.m. Concert. Small Chamber Ensemble
munology. Eric P. Newman Education pertension: Managing Without a Nephro- Center. 362-2763. Extravaganza. Elizabeth Macdonald, dir.
Center. 362-2763. logist?!" Anne Beck, asst. prof, of pedi- Holmes Lounge. 935-4841.
atrics. Clopton Aud. 4950 Children's Sunday, Jan. 22
Place. 454-6006. Thursday, Jan. 13
Tuesday, Dec. 14 3 p.m. Business Minority Council presen- Friday, Dec. 17
4 p.m. Ophthalmology & Visual Sciences tation. Martin Luther King Jr.'s contribu-
8:30 a.m.-4:30 p.m. Center for the Appli- Seminar. "Immunologic Control of HSV- tion toward equality in education and the 8 p.m. Washington University Opera.
cation of Information Technology Two- Monday, Dec. 20 1 Latency and Implications for Herpes workplace and his effect on African- Winter Evening of Opera. Jolly Stewart,
day Workshop. 'The Politics of IT Project Noon. Molecular Biology & Pharmacology Keratitis." Robert L. Hendricks, prof, of dir. Umrath Hall Lounge. 935-4841.
Americans in the business world. Simon
Management." (Continues 8:30 a.m.-4:30 Seminar. "Molecular Assembly of Hippo- ophthalmology, of immunology and of Hall. 935-7301.
p.m. Dec. 15.) Cost: $1,195, reduced fees
available for CAIT organizations. CAIT, 5
campal Synapses." Ann Marie Craig, molecular genetics & biochemistry, U. of • Sunday, Dec. 19
assoc. prof, of anatomy & neurobiology. Pittsburgh. Cori Aud., 4565 McKinley
N.Jackson Ave. 935-4444. South Bldg., Rm. 3907, Philip Needleman Ave. 362-1006. Monday, Jan. 24 3 p.m. Choral Sing-along. Handel's
Noon. Molecular Microbiology & Miero- Library. 362-0183. 4 p.m. Immunology Research Seminar Messiah. John Stewart, dir. Graham
7:30 p.m. American Technion Society Chapel. 935-4841.
bial Pathogenesis Seminar Series. Series. "How We Sense Infection: Toll-
Lecture. "Research Towards Under-
like Receptors and the Forward GenetJc
"TRIM5alpha: A Mediator of Innate Tuesday, Dec. 21 standing and Preventing Irregular Hearth
Analysis of Innate Immunity." Bruce
Intracellular Resistance to Retroviruses."
4 p.m. Anesthesiology Research Seminar Rhythms and Sudden Death." Yoram Sunday, Jan. 23
Joseph G. Sodroski, prof, of pathology, Beutler, prof, of immunology, Scripps
Series. Ling-Gang Wu, National Insti- Rudy, Fred Saigh Distinguished Professor 8 p.m. Organ Concert. In celebration of
Dana-Farber Cancer Inst, Harvard U. Cori Research Inst. Eric P. Newman Education
tutes of Health, Bethesda, Md. Clinical of Biomedical Engineering. Whitaker Hall. the Graham Chapel renovation. James
Aud., 4565 McKinley Ave. 747-2132. Center. 362-2763.
Sciences Research Bldg., Rm. 5550. To register: 725-7330. Kibbie, organist, U. of Mich. Graham
4 p.m. Anesthesiology Research Seminar 362-8560. Chapel. 935-4841.record.wustl.edu WASHINGTON UNIVERSITY IN ST. LOUIS Dec. 10,2004 5
'Tis the season
Music ensembles to present concerts throughout December
The Department of Music in Lounge. The performance will welcome to attend. Copies of the
Arts 8c Sciences will conclude also feature additional Mozart music will be available for those
its fall season with a host of arias weaved into the story line. who do not bring their own
December concerts. Finally, the music department scores.
The Concert Choir of Wash- will host its annual sing-along of John Stewart will direct the
ington University — under the George Frideric Handel's oratorio performance; William Partridge
direction of John Stewart, director Messiah at 3 p.m. Dec. 19 in will be the organist. Soloists will
of vocal activities — will perform Graham Chapel. be all students or recent graduates
works composed across six cen- The performance, which will of the music department's Vocal
turies at 8 p.m. today in Graham last about an hour, will include Performance Program; they will
Chapel. The performance will be the Christmas portion of Messiah include soprano Megan Higgins;
dedicated to former choir member ■ as well as the "Hallelujah Chorus." mezzo-soprano Deborah Stinson;
William R. Kohn, professor emeri- Those who wish to may sit in tenor Clark Sturdevant; and bari-
tus in the School of Art, who pas- special sections arranged accord- tone Nathan Ruggles.
sed away Nov. 13. ing to voice type (soprano, alto, All concerts are free and open
Representing the Renaissance is tenor, baritone), though those to the public. For more informa-
Tomas Luis de Victoria's famed "O who choose not to sing are also tion, call 935-4841.
Magnum Mysterium," followed by
a contemporary setting of the
same tune by American composer
Morten Lauridsen.
Also in the concert are works
by Baroque composers Thomas
Galumpha, a New York-based dance trio that combines physical
Weelkes and Antonio Lotti; by
comedy, acrobatic choreography and striking visual effects, will
19th- and 20th-century com-
come to Edison Theatre Jan. 15 as part of the ovations! for young
people series. posers Charles V. Stanford, Sergei
Rachmaninoff, Francis Poulenc
and Joseph Canteloube; and a
ovations! for young people 2003 setting of "My Soul's Been
Anchored."
presents Galumpha Jan. 15 At 8 p.m. Dec. 13, the music
department will present a "Small
Chamber Ensembles Concert" in
Holmes Lounge. Elizabeth Mac-
BYLIAMOTTEN The duo's performing and
donald, director of strings, will
choreographic credits include
conduct the performance, which
A three-headed human fly? To- Serious Fun at Lincoln Center in
will feature a variety of small stu-
tem poles that come to life? New York; Just for Laughs in Mon-
Velcro-helmeted weirdoes who dent-chamber ensembles. The
treal; The Staat Schowberg in Am-
defy the laws of physics? program will include string quar-
sterdam; Man-Made at New York's
Is this a horror movie or a tet selections by Franz Schubert,
Joyce Theater; Ireland's Galway
Antonin Dvorak and Maurice
comic book? Arts Festival; and Spoleto-USA in
No, it's Galumpha, a New Ravel; "Cries of London" for viols
Charleston, S.C., among many
York-based dance trio whose dar- and voice by Thomas Weelkes;
others.
ing combination of physical com- and tangos for cello, arranged by
Other projects range from
edy, acrobatic choreography and Macdonald.
"Ecstasy," an MTV video with the
striking visual effects is quickly Also at 8 p.m. that evening,
band Rusted Root, to a Japanese
earning a national following. the Washington University Flute Holiday print Sale Island Press, the School of Art's nation-
television commercial, the British
In January, the troupe will Choir, directed by Jan Smith, will ally renowned professional printshop, will host its second-
game show The Generation Game
descend upon St. Louis for a spe- perform a concert in Graham annual holiday sale from 11 a.m.-4 p.m. Dec. 19 in Blxby Hall.
and more than 1,000 workshops
cial, one-time-only matinee at Chapel. The event will feature works by dozens of Internationally
and lecture demonstrations for
Edison Theatre. The Washington University renowned artists — including James Barsness, Chakala
children.
Opera, directed by Jolly Stewart Booker, Michael Byron, Hung Liu, Shimon Okshteyn, Franco
The performance, presented as As Galumpha, Horowitz,
and conducted by John Stewart, Mondini Ruiz, Jane Sauer and Catherine Wagner — at dis-
part of the Edison Theatre ova- O'Brien and Torres have toured
will present Mozart's short comic counts of 30 percent to 50 percent off list prices. Among the
tions! for young people series, will widely, performing at venues works offered will be Louie Louie (above), a soft-ground etch-
begin at 11 a.m. Jan. 15. opera The Impresario at 8 p.m.
around the world and earning a ing by Rocky Toner. For more information, call 935-6571.
According to anthropologists, Dec. 17-18 in Karl Umrath Hall
prestigious Edinburgh Festival
"galumphing" is the manifestation Critic's Choice Award. They have
of the seemingly inexhaustible been featured on MTV, Showtime,
store of play-energy one finds in A8cE and The Late Show With
children, puppies, kittens and
other higher fife forms.
David Letterman, among many
others, and in Jerry Lewis's 2002
Sports
"We galumph when we hop Muscular Dystrophy Association
instead of walk," writes Stephen Telethon.
Nachmanovitch in Free Play: Ovations! for young people Swimmers, divers [iff fell in the opening game of the
tournament to Benedictine
Improvisation in Life and Art,
"when we take the scenic route
presents affordably priced — and shatter school records University, 100-95.
family friendly — matinee shows For complete sports schedules and
instead of the efficient one." The men's and women's swimming The Bears broke the record of
by nationally and internationally results, go to bearsports.wustl.edu.
Galumpha the dance company and diving teams continued their 15 3-pointers, which they reached
recognized performing artists.
delivers a fast-paced, athletic mix strong performances at the Whea- three times. Senior Rob Keller fin-
The series compliments the signa-
of art and entertainment, obliter- ton College Invitational. The IM (2:08.97). She was a part of ished the game with a career-high
ture Edison Theatre OVATIONS!
ating boundaries between the women broke two more school four school records and seven 26 points while junior Mike Grunst
series, which serves both the
ridiculous and the sublime. records on the final day of compe- NCAA qualifying times for the had a career-high 19 points.
University and the St. Louis com-
The troupe was formed in tition, bringing their two-day total weekend. In the consolation champion-
munity by providing the highest
2002 by Andy Horowitz and Greg to six, en route to a third-place Juniors Michael Slavik and ship, the Bears improved to 4-3
caliber national and international
O'Brien, artists-in-residence at finish at the Invitational. The Eric Triebe paced the men's with an 86-70 win over Principia
artists in music, dance and the-
Binghamton University. Rounding women posted 591 points, behind squad. Both swimmers provision- College Dec. 4. WUSTL followed
ater, performing new works as
out the team is Marlon Torres, a University of Wisconsin-Milwau- ally qualified for the NCAAs in record 3-point performance with
well as innovative interpretations
former child television star in his kee (600) and host Wheaton two freestyle events: Slavik in the 12 more against Principia.
of classical material not otherwise
native Venezuela. (801.5). 50 free (21.13) and 200 free Michael Faherty led five Bears
seen in St. Louis.
Horowitz and O'Brien have The men placed fourth with (1:42.07) and Triebe in the 50 free in double figures with 15 points.
Edison Theatre programs are
performed together for more than 539 points, behind University of (21.01) and 200 free (1:43.00).
supported by the Missouri Arts
20 years, having met as students at Council, a state agency, and the
Wisconsin-Stevens Point (580), A day earlier, both competitors Women's hoops team
UW-Milwaukee (710.5) and earned NCAA "B" cuts in the 100
Binghamton (then the State Uni- Regional Arts Commission,
Wheaton (760.5). free. The 200-medley relay squad wins two more games
versity of New York-Binghamton) St. Louis.
Freshman Tina Deneweth set a of Slavik, Triebe, freshman Geoff The No. 4 women's basketball
in 1982. They formed their first Tickets are $7 and are available
school record in the 100-yard but- Hart-Cooper and junior Alex team won a pair of games at the
troupe, The Sticks, in 1986 and in at the Edison Theatre Box Office
terfly, recording a time of 57.01. Antilla posted a time of 1:34.96 to Colorado College Classic. With the
1987 commenced a 15-year run and through all MetroTix outlets.
The mark also automatically quali- earn an NCAA "B" cut. two wins, the Bears improved to
with dancer Paul Gordon as The For more information, call
fied her for the NCAA Champio- Slavik, Antilla, sophomore 7-0. WUSTL defeated host Colo-
Second Hand Dance Company. 935-6543.
nships. The second women's David Stein and Triebe also rado College, 79-60, Dec. 3. Alicia
record that fell on the day came teamed up in the 400-free relay to Herald paced the Bears with a ca-
courtesy of the 200-medley relay provisionally qualify with a time reer-high 20 points and eight re-
& 3:30 p.m. Dec. 12.) Cost: $20. Mudd
Monday, Jan. 24 Hall Multipurpose Room. 935-6098. team. The foursome of freshman of 3:06.73. bounds. Senior Kelly Manning fin-
I p.m. Concert. Washington University Meredith Nordbrock, junior Allie On the weekend, the women ished with 18 points, six rebounds,
Chamber Orchestra. Elizabeth Macdonald, Boettger, Deneweth and junior broke six school records and post- four assists and three steals.
dir. Umrath Hall Lounge. 935-4841. Tuesday, Jan. 11
Jenny Scott clocked an NCAA "A" ed 14 NCAA qualifying times. WUSTL wasted little time tak-
1-2:30 p.m. Center for Mental Health
Services Research Open House. Brown cut time of 1:47.28. The men set a pair of school re- ing control of the next day's 86-42
Hall Lounge. 935-5687. Nordbrock and Scott also auto- cords and tallied 10 NCAA quali- win against Pomona-Pitzer Col-
And more... Monday, Jan. 24
matically qualified for NCAAs in
an individual event. Nordbrock
fying times. leges. The Bears tallied the game's
first 11 points, led by Danielle
Friday, Dec. 10 11:30 a.m.-4:30 p.m. Blood Drive. Co- took first place in the 100 back- Men's basketball team Beehler's six points during the
sponsored by Phi Delta Theta fraternity stroke. Scott earned an NCAA "A" run, en route to a 48-16 halftime
7 p.m.-1 a.m. Tango/Swing/Salsa Dance and Kappa Kappa Gamma sorority. (Also cut in the 200 free with a time of takes third place cushion. Beehler finished with 13
Event. Umrath Hall Lounge. 935-6098. 11:30 a.m.-4:30 p.m. Jan. 25, Mallinc- 1:53.59. The men's basketball team won points in 19 minutes of action. In
krodt Student Center, Lower Lvl. The Nordbrock set two school the consolation championship at all, 12 players scored for WUSTL.
Saturday, Dec. 11 Gargoyle, and 5-10 p.m. Jan 26 & 27,
Wohl Student Center, Friedman Lounge.) records on the first day of the the Bill Merris Tip-Off Classic in Senior Nicole Wylie matched
2 & 3:30 p.m. Tango Workshop. Brigitta Mallinckrodt Student Center, Lower Lvl., Invitational; she broke the mark in Jacksonville, 111. Despite a school- Beehler with a game-high 13
Winkler, tango instructor, Berlin. (Also 2 The Gargoyle. 291-4741. the 200 back (2:08.06) and the 200 record 16 3-pointers, the Bears points off the bench.6 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS
The company is aggressively the Olin Cup competition were The Skandalaris Center for
Lab
- from Page 1
Olin marketing the technology for out-
licensing while pursuing drug dis-
covery-based in-house research
selected from the St. Louis com-
munity as well as nationally, Har-
rington said, and were matched
Entrepreneurial Studies is one of
the Top 25 business-school entre-
preneurship programs nation-
- from Page 1
designed to capture sizeable por- with Olin School teams. More wide, based upon Entrepreneur
tions of the degenerative disease than 50 business-school teams Magazine's comprehensive rank-
weak enough to serve as vac- registered in this year's compe-
porate partners who are interested market and bring a minimum of ings. It is a member of the Ewing
cines." 25 times return on investment in tition.
in the promotional aspects of our Marion Kauffrnan Foundation
According to the U.S. Centers Ten teams made it to the semi-
program, including prominent the next five years. National Consortium for Life
for Disease Control and Preven- finalist round; five teams were
representation on the new Olin The Blessing Basket Project Science Entrepreneurship.
tion, noroviruses are involved in selected as finalists.
Cup Web site." was founded by Theresa Wilson, The Kauffrnan Foundation
about half of all food poisoning Those finalists made two-
One of the primary goals of whose team includes Olin School recently selected WUSTL as one
cases and annually cause about minute "elevator pitches," pre-
the Olin Cup competition, Har- undergraduate and graduate stu- of eight U.S. universities to share
23 million cases of acute gas- pared detailed business plans and
rington said, is "cross-campus col- dents. The first nonprofit entry in $25 million in grants through a
troenteritis in the United States. made final presentations to the
laboration" among WUSTL's top- Olin Cup history, The Blessing program designed to make entre-
Norovirus disease is character-
ranked business, medical, law, Basket — 501 (c)3 pending — is a Olin Cup judges. preneurship education available
ized by frequent vomiting and "The Olin Cup competition
engineering and other schools social entrepreneurship venture across campus and transform the
diarrhea over the course of 1-2
and among the vibrant and started more than a year ago in adds to the vibrant St. Louis start- way entrepreneurship is viewed,
days. The most infamous noro-
diverse business community lead- pilot locations in six developing up community," Harrington said. taught and experienced. WUSTL
virus, the Norwalk virus, was first "It's truly amazing to see how
ers in the St. Louis area. countries. received a grant of $3 million.
identified after a 1968 outbreak quickly companies form when
Luminomics was founded by The Blessing Basket pays wea-
at a school in Norwalk, Ohio. people from different disciplines
Jeffrey S. Mumm, Ph.D. The com- vers in undeveloped countries the
The Norwalk virus also caused a
pany creates disease models and prosperity wage (which is multi- create a collaborative environ-
series of repeated outbreaks on
performs high-throughput screens ples higher than the local aver- ment."
cruise ships in 2002 and in mili-
tary personnel in Afghanistan.
Although such infections rare-
ly lead to serious or life-threaten-
to discover small molecules that
stimulate cellular regeneration.
Lead compounds capable of stim-
age), imports high-quality baskets
and sells them via its Web site,
direct sales and retail relation-
The annual Olin Cup Compe-
tition was founded in 1987 as part
of The Hatchery entrepreneurship
Center
ing illness in the United States
ulating regeneration in the mo- ships. Revenues above expenses course at the Olin School. The Opened in 1994; has
del system will be used to iden- are reinvested into additional pro- Olin Cup competition as a sepa- done pioneering work
and other Western countries, they
tify regenerative therapies for duct and economic/community rate entity was launched in 2002,
spread rapidly, are difficult to - from Page 1
humans. development projects. with a new emphasis on life sci-
prevent from spreading and can
Luminomics is focused on four Core Devices, founded by John ences, medicine and technology
create considerable discomfort.
major neurodegenerative disor- Izuchukwu, received an honorable startups, as well as other student-
Dehydration from the diarrhea health care has enormous
ders, but the platform can be mention for its portable anesthe- started ventures.
and vomiting induced by the potential to ensure treatment
applied to any degenerative dis- sia machine. The machine is de- To date, the competition has
virus sometimes leads to hospi- to persons whose disorder
ease state or condition, said signed to facilitate the delivery of resulted in the formation of more
talization in the elderly, the currently goes undetected, to
Mumm, who earned a doctorate care outside traditional hospital than 50 new businesses by Olin
young or those with weakened extend evidence-based care to
in biology and biomedical sci- settings. School business students and
immune systems. those who have been poorly
ences from the University. Ac- Likely applications include alumni.
In the developing world, these served and to reduce racial
cordingly, the company is partner- civilian and military operations, An event Feb. 10 will mark the
viruses are a major cause of hu- disparities in care."
ing with other companies to pro- as well as private physician clinics, opening of registration for new
man illness. CMHSR opened in 1994 as
vide tailor-made disease models rural hospital settings and austere teams for the next Olin Cup entre-
All previous attempts to cul- the nation's first NIMH-fund-
and screening-outsource services environments anywhere in the preneurship competition. Teams
ture human noroviruses in tis- ed social work research devel-
for their specific degenerative world. may then register at www.olin
sues in the laboratory have been opment center. Its research
targets. Judges and team mentors for .wusd.edu/cel/olincup/register.cfrn.
unsuccessful. projects represent some o: the
"As a group, noroviruses have pioneering clinical epidemio-
defied characterization for de- logical, service-systems and
cades because there just hasn't
been a way to get the virus to
grow outside of a human host,"
Reactor quality-of-care research in
mental health and social
services.
from Page 1
Virgin said. The center's future work
In 2003, Christianne Wobus, will build on its prior decade
Ph.D., and Stephanie Karst, unbounded water was converted of mental-health research in
Ph.D., two postdoctoral fellows to steam, decreasing the thermal the social services.
in Virgin's lab, identified MNV-1, neutron flux and making the reac- "The center's research
the first known mouse norovirus. tor sub-critical." agenda is built around pro-
Virgin's group showed that the ("Critical" means that a fis- jects with Missouri's Child-
mice's ability to fight MNV-1 sionable material has enough mass ren's Division and Division of
relied heavily on the innate im- to sustain a reaction.) Senior Services and Regula-
mune system, the branch of the "It took at least 2.5 hours for tion," said J. Curtis McMillen,
immune system that attacks in- the reactor to cool down until fis- Ph.D., center associate director
vaders soon after they enter sion Xe (xenon) began to retain," and associate professor of
the body. the researchers continued. "Then social work.
In the newly published study, the water returned to the reactor "It includes a range of pro-
Virgin's group reveals that MNV- zone, providing neutron modera- jects and studies designed to
1 likes to infect cells of the innate tion and once again establishing a Alexander Meshik holds a tiny piece of rock from the only known enhance quality improvement
immune system. In tests in mice, self-sustaining chain." natural nuclear chain reaction site in the world — in Gabon, West research methodology. With
the researchers found the virus Prior to this calculation, it was Africa. Olga Pravdivtseva and University colleague Charles Hohen- this new center, we are moving
thrived in macrophages, im- known that the natural nuclear berg collaborated on an isotoplc analysis of a tiny portion of the from studying how mental-
mune-system cells that normally reactor operated 2 billion years sample that reveals how this natural nuclear reactor worked. health issues are handled in
engulf and destroy pathogens, ago for 150 million years at an these sectors of care to devis-
and in dendritic cells, sentry-like average power of 100 kilowatts. from the Oklo mine was depleted noted the importance of alu- ing and implementing strate-
cells that pick up and display The WUSTL team solved the mys- in 235 Uranium, it was discovered mophosphate in the natural nu- gies to improve services.
proteins from pathogens. tery of how the reactor worked and that the site had once been a nat- clear reactor. "Ultimately, we hope to
"We think there may be den- why it didn't blow up. ural nuclear reaction system. "More krypton 85, a major develop system modifications
dritic cells just beneath the lining Meshik and his collaborators, "The big question we addres- waste from modern nuclear reac- for public social-service agen-
of the human gut that are pro- Charles M. Hohenberg, Ph.D., sed was: When it reached critical- tors, is getting piped into the at- cies that will result in better
viding the gateway the virus professor of physics, and Olga ity, why didn't it blow up?" Me- mosphere each year," he said. detection of mental disorder
needs to cause disease," Virgin Pravdivtseva, Ph.D., senior re- shik said. "We found the answer "Maybe this natural mode can and access to treatment."
said. search scientist in physics, used a in the xenon." suggest a safer solution." In addition to Proctor and
To grow the virus in the lab, selective laser combined with sen- There were two major theories Can there be a natural nuclear McMillen, CMHSR's investiga-
researchers took dendritic cells sitive, ion-counting mass spec- on how the reactor operated. One reactor in actual operation today? tors include 35 Ph.D./M.D-
and macrophages from mice with trometry to concentrate on the held that the system burned up "Today, even the largest and level researchers from around
defective innate immune systems sample's moderator, a uranium- highly neutron-absorbing impuri- richest uranium deposit cannot the University and across the
and exposed them to the virus. free mineral assembly of lan- ties such as rare Earth isotopes or become a reactor because the nation.
"The virus grew beautifully," thanum, cerium, strontium and boron, and because of that the sys- present concentration of 235 U is The center has engaged the
Virgin said. "It's a very facile and calcium called alumophosphate. tem shut down regularly, and dif- too low — only about 0.72 per- expertise of a variety of disci-
robust system." The xenon found and analyzed ferent parts of the reactor might cent," Meshik said. "However, plines, including social work,
Comparisons of MNV-1 and provides the story of this ancient have operated at different times. because 235 U decays much fas- anthropology, epidemiology,
human noroviruses have reveal- natural nuclear reactor. Meshik and The other involved the role of ter than 238 U, in the past, 235 U gerontology, health economics
ed many similarities in gene se- his colleagues inferred from the water acting as a neutron moder- was more abundant. and policy, journalism, public
quence, structure and overall xenon analysis the mode of opera- ator. As the temperature of the "For example, 2 billion years health, library science, biosta-
arrangement of the genome. tion and also the method of safely reactor went up, water was con- ago, 235 U was five times higher, tistics, business, medicine, psy-
But Virgin acknowledged that storing nuclear wastes, particularly verted to steam, reducing the about 3 percent, approximately chiatry, psychology, law, bio-
differences between mouse and fission xenon and krypton. neutron thermalisation and shut- the concentration of enriched ethics and sociology.
human physiology may signifi- "This is very impressive, to ting down the chain reaction. The uranium used in modern com- "From the perspective of
cantiy alter MNV-l's interactions think this natural system not only chain reaction re-started only mercial reactors." the school, the launch of this
with its host. went critical, but it also safely when the reactor cooled down Another vital condition for new center is exciting not only
For example, mice do not ap- stored the waste," Meshik said. and the water increased again. self-sustaining nuclear reaction is for the advanced mental
pear to be able to vomit. Addi- "Nature is much smarter than we Analysis of the xenon, the the high content of a moderator health services research that
tionally, researchers aren't sure are. Nature is the first genius. largest concentration of xenon to slow the neutrons, Meshik said. will be produced, but also for
yet whether MNV-1 can make "We have all kinds of problems ever found in any natural materi- Water, carbon, most organic com- the outreach to social-services
mice with normal immune sys- with modern-day nuclear reactors. al, confirmed the water method. pounds, silicon dioxide, calcium agencies to improve the quali-
tems sick. This reactor is so independent, It also revealed the role of alu- oxide and magnesium oxide are ty of services delivered," said
"The bottom line is that this with no electronics, no models. mophosphate as the system's all natural neutron moderators. Edward F. Lawlor, Ph.D., dean
mouse model provides us with a Just using the fact that water waste absorber. Also, the concentrations of of the School of Social Work
very useful way to examine cer- boiled at the reactor site might Xenon is extremely rare on neutron absorbents — iron, and the William E. Gordon
tain similar aspects of the noro- give contemporary nuclear reactor Earth and very characteristic of potassium, beryllium and espe- Professor.
viruses," Virgin said. "Among researchers ideas on how to oper- the fission process. Chemically cially gadolinium, samarium, For more information
other things, we'll be using it to ate more safely and efficiendy." inert, the element has nine iso- europium, cadmium and boron about the center or the open
look at how the capsid protein In 1952, Paul Kuroda predicted topes and is abundant in many — should be low. house, call the center at
enables infection, viral replica- that if the right conditions existed, nuclear processes. "Only when all of these re- 935-5687 or go online to
tion processes and the receptors a natural nuclear reactor system "You get a big diagnostic fin- quirements are met can a self- gwbweb.wusd.edu/users/
on host cells that enable the virus could go critical. Twenty years gerprint with xenon, and it's easy sustaining chain reaction occur," cmhsr.
to infect specific cell types." later, noticing that uranium ore to purify," said Hohenberg, who Meshik said.You can also read
