The next genera+on of nature - OTCQX: CANSF - Willow Biosciences

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The next genera+on of nature - OTCQX: CANSF - Willow Biosciences
The next genera+on
                of nature.

July 2021                      TSX: WLLW
willowbio.com               OTCQX: CANSF
The next genera+on of nature - OTCQX: CANSF - Willow Biosciences
Willow’s technologies & capabilities

        WILLOW IS FOCUSED ON DEVELOPING COMPLETE PROCESS SOLUTIONS THAT COMBINE STATE-OF-THE-
                ART TECHNOLOGIES FOR STRAIN, FERMENTATION & DOWNSTREAM PROCESS DEVELOPMENT

       P R O C E S S D E V E L O P M E N T (USP & DSP)
                       (Undisclosed DSP Technology Partner)
                                                                                                       SCALE UP            (other CMOs)

   INPUT
   Willow’s Rapid Strain Engineering
                                                                            bench scale                   TESTING & RELEASE
   Technologies combine:
   ü    Proprietary plant genomes
   ü    Machine learning-guided                                                                                        OUTPUT
        pathway optimization
                                                              performance                                              Ingredients:
   ü    Enzyme evolution platform                                 strain
                                                                                            pilot &                    ü    Consumer care
   ü    Genome-wide editing
                                                                                          production                   ü    Flavor & fragrance
        technologies
                                                                                                                       ü    Food & beverage
   ü    HTP screening capabilities
                                                                                                                       ü    Pharma
                                                                             lab strain

                                                                                                                                                 P A G E   2
The next genera+on of nature - OTCQX: CANSF - Willow Biosciences
Our commitment to managing sustainability

     OUR FERMENTATION PROCESS ENABLES RESOURCE EFFICIENT AND SUSTAINABLE GROWTH

     Key environmental performance comparison

 Willow’s biosynthesis process vs plant-based cannabinoid production1
                                                                                                                                                                                                                                                 Other Willow business priorities:
      Relative CO2 emissions per                                                              Relative water requirements                                                            Kilograms biomass per
      kilogram CBD produced2                                                                  per kilogram CBD produced3                                                             kilogram CBD produced4

      600                                                                                     400                                                                                    200
                                   527x                                                                                                                                                                                                                          PEOPLE
                                                                                                                                                              333x
      500
                                                                                                                                                                                                                 150             150
                                                                                             300
                                                                                                                                                                                                                                        142
      400

                                        ≠                                                                                                                                                                                                                        PARTNERS
      300                                                                                                                                                                            100
                                                                                             200

      200
                                                     155x
                                                                                              100
      100                                                                                                                    58x              58x                                                                                                                SAFETY
                                                                      44x
                 1x                                                                                          1x
                                                                                                                                                                                                  0.1
       0                                                                                        0
                                                                                                                                                                                       0
            fermentation warehouse greenhouse                       outdoor                          fermentation warehouse greenhouse                         outdoor                     fermentation warehouse greenhouse           outdoor
                                                                                                                                                                                                                                                                 PRODUCT
                                                                                                                                                                                                                                                                 QUALITY
Land use:
Fermentation and indoor cultivation facilities can be located on property with sufficient access to labour and utilities, avoiding the need to devote arable
land to non-food production. The uncontrolled environment of outdoor cannabis operations can lead to heavy pest and weed pressure, leading to crop
failures and wasted resources.

1.     Assumes average dry flower yield of 10% CBDa (w/w) or CBDa production of 5 g/L in 100,000L fermentation facility.
2.     Posterity Group (2019) Report of Findings: Greenhouse Energy Profile Study; & Willow management estimates. Emissions calculated using Government of Alberta (2019) Carbon offset emission factors handbook. Version 2.0
3.     Upland Agriculture Consulting (2019) Commercial cannabis production in British Columbia: best available control technologies and regulatory oversight of environmental considerations; & Willow management estimates
4.     Willow management estimates
                                                                                                                                                                                                                                                                                P A G E   3
The next genera+on of nature - OTCQX: CANSF - Willow Biosciences
Our ESG committee

STRONG FRAMEWORK IN PLACE TO MONITOR SUSTAINABILITY METRICS

                                                                                    BOARD MEMBER
                                                                           Compensation & Governance Committee Chair

   Our commitment to
   managing sustainability                                                                TRAVIS DOUPE
                                                                                              CFO
    •   Establish ESG governance structure
        with board level oversight (2021)

    •   Conduct materiality assessment to
        identify and prioritize key topics for
        our business and to our
        stakeholders (2021)
                                                 customer needs             investor relations           environmental         governance & social

    •   Develop a robust ESG strategy and          SIMON                        TROY                      MARK                       KIM
        roadmap (2021)                            HICKLING                    TALKKARI                  SMOLENSKI                   MARTYN

                                                 Senior VP Business           VP Corporate              Senior Director              General
    •   Disclose ESG performance (2022)            Development                Development           Manufacturing Operations         Counsel

                                                                  INPUTS                                          OUTPUTS

                                                                                                                                               P A G E   4
The next genera+on of nature - OTCQX: CANSF - Willow Biosciences
Willow’s cannabinoid production process

COMBINING STRAIN ENGINEERING WITH PROCESS DEVELOPMENT TO DEVELOP BIOBASED ROUTES TO CANNABINOIDS

                                                                                                   Cannabinoid                   OH
                                       Controlled input:                                          decarboxylation
                                       • Basic nutrients                                         (purity & potency
                                       • Carbon source feed                                            >99%)               HO
                                       • Substrate feed
                                       • 4-5-day process
                                                                                                     Chemical
                                                                                                                      e.g., cannabigerol, CBG
                                                                                                  Decarboxylation

     Performance
         Strain                                                       Cannabinoid
                                                                     isolation from                                              OH
                                                                      fermentation                 Cannabinoid                        COOH
                                                                                                 (purity & potency
                                                                          broth
                                                                                                       >99%)
                                                                                                                           HO

                                Fermentation                        Primary Isolation
                                                                                                    Purification     e.g., cannabigerolic acid, CBGA

                Upstream Process (USP)                                          Downstream Process (DSP)

      BENEFITS OF BIOSYNTHESIS

       •   Yeast produces only target cannabinoid with no interfering by-products
       •   DSP typically requires no chromatography to achieve high purity
                                                                                                                                Formerly AMRI
       •   Only minor process changes for other cannabinoids
       •   Platform easily extends to production of other cannabinoids and terpenes
                                                                                                                                                       P A G E   5
The next genera+on of nature - OTCQX: CANSF - Willow Biosciences
Demonstrated ability to commercialize compounds

WE HAVE LAUNCHED OUR FIRST COMPOUND AND HAVE A ROBUST PIPELINE OF FUTURE HIGH VALUE MOLECULES

      compound            potential addressable markets               lab strain   optimized strain   pilot ready   scale production    launch

      CANNABINOIDS

      CBG/CBGA           Cosmetics, food & beverage                                                                                      Now
      THC/THCA           Food & beverage, pharma
      CBD/CBDA           Cosmetics, food & beverage, pharma
      CBN/CBNA           Sedative & sleep aid
      CBGV/CBGVA         Cosmetics, food & beverage, pharma
      THCV/THCVA         Appetite suppressant, pharma
      CBDV/CBDVA         Cosmetics, health & wellness, pharma
      Undisclosed        Cosmetics, food & beverage
      Undisclosed        Food & beverage

      OTHER CLASSES

      Terpenes           Cannabis additives, flavors & fragrances

       In just over two years, we have gone from proof of concept in the lab to commercially producing our first cannabinoid, CBG. Based on this
       success and the platform technology our next cannabinoids will take less time and capital

                                                                                                                                                   P A G E   6
The next genera+on of nature - OTCQX: CANSF - Willow Biosciences
Technology in action: from lab to production

      PROGRAM 1 IS THE BASIS FOR THE ENTIRE PLATFORM

                     Development of Commercially Relevant Strains & Process      SCALING AND REFINING PROCESS

               100

               90                                                                                 CBG   – Currently at production scale
               80

               70
                                                                                                  THC – Currently at bench scale
(% COMPLETE)

               60

               50
                                                                                                  CBD – Currently at lab scale
               40

               30

               20                                                                                 Varins   – Currently at lab scale

                10

                0
                                                                                                  Non-Cannabinoid – Currently at
                                                                                                                            screening stage
                        2020             2021             2022            2023     2024

                                                                                                                                          P A G E   7
The next genera+on of nature - OTCQX: CANSF - Willow Biosciences
CBG – A health and wellness molecule

THE NEXT BIGGEST CANNABINOID FOR HEALTH AND WELLNESS

                                                                    •       In the plant, cannabigerol (CBG) is converted to other cannabinoids such as THC and CBD, hence the
                           CBGA                                             nickname “Mother of All Cannabinoids”
                            master acidic
                             precursor
                                                                            ‒ CBG naturally occurs at such small concentrations that it is challenging to manufacture economically with high purity levels

                                                                            ‒ Non-psychoactive properties allow for a favorable global regulatory view (not on the U.S. Controlled Substances Act)

                                                                    •       Of the more then 450 chemicals identified in the cannabis plant, CBG is one of the most compelling from
                                                                            the perspective of human health

        CBDA                                THCA                    •       CBG has the potential to be as impactful to the recreational, health and wellness landscape as CBD has
                                            acidic precursor
                                                                            become
        acidic precursor

                           CBG                                              ‒ As an anti-inflammatory, CBG has been shown to outperform CBD under certain conditions

                           neutral
                                                                    •       Global CBD market estimated at $2.7 billion in 2021 and forecast to grow at CAGR of 51% from 2021 to 20301.
          CBD                                 THC                           CBG’s ability to be a substitute or even superior molecule, implies large potential addressable market
           neutral                            neutral
                                                                        1
                                                                            SOURCE: Quince Market Insights June 1, 2021

Willow’s Ultra-Pure CBG                                                                                                                 Health & Wellness Products
(Input)                                                                                                                                 (Output)
                                                               Characteristics of Willow’s CBG make
                                                               it ideal for product integration:
• Anti-microbial                                                                                                                                                                               >$1 trillion
                                                               •   >99% purity
                                                               •   Consistent batches                                                                                        CBG             global market
• Anti-oxidant
                                                               •   Odorless
• Anti-inflammatory                                            •   Powder form

                                                                                                                                             = GRAS designation required (Willow pursuing)

                                                                                                                                                                                                              P A G E   8
The next genera+on of nature - OTCQX: CANSF - Willow Biosciences
CBG – a potent skincare active ingredient

       Global cosmetics market was valued at $380 billion in 2019 and projected to reach $464
       billion by 20271, with the largest portion being skin and sun care products

                                                                                                                                       Anti-bacterial
                                                                                                                                        • Prevents bacterial growth in
                                                                                                                                           skin, including, C. acnes
                    Anti-aging

                   • Stimulates Sebocyte gland in
                        skin which releases moisture
                                                                                                                                     Anti-inflammatory
                   • Increases collagen production                                                                                   • Suppresses inflammation in skin
                                                                                           cannabigerol                                  induced by bacteria, UV and other
                                                                                                (CBG)                                    environmental factors

  1.    Source: Feb 2021 industry report by Allied Market Research

 March 2021                                      April 2021                           May 2021                                 June 2021                         2021+
 first commercial production                     completed a series of studies        the European Commission adds CBG to      signed multi-year supply           continue to sign new
 run of Willow CBG                               demonstrating the safety and anti-   the EU’s cosmetic ingredients database   agreement with Cellular Goods      partnerships and potentially
                                                 inflammatory, anti-aging, and        (named "CosIng"), approving the                                             bring own skin care products to
                                                 antimicrobial properties of Willow   compound as safe for use in personal                                        market
                                                 CBG on human skin                    care and cosmetics products

                                                                                                                                                                                          P A G E   9
The next genera+on of nature - OTCQX: CANSF - Willow Biosciences
Growing portfolio of cannabinoids

WILLOW’S PRODUCTION SUCCESS WITH CBG IS TRANSFERRABLE TO OTHER CANNABINOIDS

          CBG                    THC                      CBD                    CBGV                     THCV                     CBDV                            CBN
       cannabigerol          tetrahydrocannabinol         cannabidiol            cannabigervarin       tetrahydrocannabivarin       cannabidivari                 cannabinoid

 • Antimicrobial            • Pain                  • Inflammation            • Inflammation           • Appetite               • Brain and                    • Sleep aid or
 • Antioxidant effects      • Sleep aid             • Recovery                • Recovery                 suppressant              peripheral nervous             sedative
 • Digestion and            • Stimulates            • Pain                                             • Brain                    system                       • Regulate immune
                                                                              • Pain
   intestines                 appetite              • Brain and central                                • Bone growth            • Nausea                         system
                                                                              • Brain and central
 • Inflammation             • Muscle relaxant         nervous system            nervous system         • Metabolism             • Seizures                     • Inflammation
 • Nausea                                           • Cardiovascular          • Cardiovascular                                  • Immunity
 • Pain                                               system                    system

      This is a summary of research interest(s) for each cannabinoid being discussed. These statements have not been evaluated by Health Canada and the US Food
      and Drug Administration, nor any regional regulatory body. This ingredient is not intended to diagnose, treat, cure, or prevent any disease.

     • Growing knowledge and acceptance of cannabinoid benefits
          ‒ ~50 cannabinoid-based treatments currently in clinical trials

     • Requires consistent, high-quality ingredients
                                                                                                             minor cannabinoid                         major cannabinoid
     • Early-stage potential for growing range of cannabinoids for pain, anxiety,
          obesity, brain disorders, cancer treatments and more
                                                                                                                                                                                P A G E   1 0
Global acceptance of cannabinoids presents large addressable market

                              Potential global CPG market for biosynthetically produced cannabinoids estimated at $8b in 2025 and $27b in 20301

1. Source: Raymond James, Ltd. (June 23, 2020 report)
                                                                                                                                                  P A G E   1 1
Willow’s best in class management & technical team

WILLOW’S TEAM HAS THE NECESSARY EXPERIENCE TO ACHIEVE SUCCESS

  Proven scientific team
                                                                                           Vancouver, BC   •       Plant Sciences R&D
  • Extensive industrial biotech expertise and essential capabilities for building
                                                                                                           •       Quality Assurance
    successful cannabinoid production strains & processes: gene discovery, high
                                                                                                           •       Quality Control
    throughout strain optimization and process development
  • Total headcount 55
         o Research & development
         o CMC group managing CMO network
         o Quality group, including QC testing & release
         o Product development & business development teams
                                                                                                               •   Strain Engineering
                                                                                     Mountain View, CA
                                                                                                               •   Fermentation R&D
                                                                                                               •   Commercial Operations
  Successful business team
  • Management team cofounded five companies, all of which successfully sold for
    > $4 billion in aggregate
         o Raised more than $1 billion in equity and debt
  • Diverse board of directors cofounded seven companies, all of which
    successfully sold for > $8 billion in aggregate
  • Strong focus on corporate governance – experienced, knowledgeable and
    diverse board, with all independent directors, other than CEO

                                                                                                                                           P P
                                                                                                                                             AAGG
                                                                                                                                                E E 162
Strong financial position

STRATEGIC INDUSTRY AND FINANCIAL PARTNERS POSITION WILLOW FOR A STRONG FUTURE PERFORMANCE

     In February 2021, raised $28.75 million via prospectus offering to support
                                                                                       Willow share capitalization (TSX: WLLW) – As of March 31, 2021
     research, strain development, scale up and commercial launch
                                                                                       Basic shares outstanding (mm)                                                                              123.5
     $77.3 million raised to date with management and board investing
                                                                                       Employee options                                                                                           7.7
     more then $8 million personally into Willow
                                                                                       Warrants (mm)2                                                                                             16.7
     March   31st,   2021 cash position equals $46.5 million with no debt
                                                                                       Performance warrants (mm)3                                                                                 12.1
     Strong insider ownership at 31%                                                   Fully diluted shares outstanding (mm)                                                                      159.9

     Aligned with shareholders – Insider's performance incentive achieved
                                                                                  1.   Weighted average strike price of $1.40
     when WLLW has 20 day VWAP of $3.50 per share                                 2.   15.0mm issued in the April 2019 financing to strategic investors, management and board with a 5 year term.
                                                                                       These warrants have a strike price of $0.88 per share. 1.0mm broker warrants issued in connection with the
                                                                                       February 2021 financing with a 2 year term, strike price of $2.15 per warrant and the ability for Willow to force
     Funded to commercialize production                                                convert at a 20 day VWAP of $3.05. Remaining warrants have a weighted average strike price of $8.01 per share.
                                                                                  3.   Additional warrants issued if the 20 day VWAP exceeds a share price of $3.50 per share and Willow is listed on
                                                                                       the TSX (or equivalent exchange).c
     Moved to TSX in Dec 2019 (TSX: WLLW)

     Trade on OTCQX® Best Market (OTCQX: CANSF)

                                                                                                                                                                                                           P A G E   1 3
Strong foundation built for future growth

   2019                              2020                                     2021                                                 2021+

   •   Go public transaction via     •   Commenced scale-up of CBG
                                                                              •   Added THC to portfolio of cannabinoids, to be
       RTO raised $37 million with       with AMRI                                                                                     Continue to sign
                                                                                  sold in Canada (or other fully legal             •
       Tuatara Capital                                                            jurisdictions)                                       up CBG related
       committing $20 million to
       financing                                                                                                                       supply agreements
                                                                              •   Raised $28.75 million via prospectus offering
                                     •   500-liter production pilot for CBG
                                         kicked off six months ahead of
                                                                                  Completed first commercial scale                 •   Commercialize
                                                                              •
                                         schedule                                 fermentation run of CBG                              additional
                                     •   Added multiple new cannabinoids
                                                                                                                                       cannabinoids
                                                                              •   Announced ground-breaking scientific data for
   •   Started build out of the          to portfolio (CBD, CBGV, THCV,           CBG on human skin, shown to be anti-aging,
                                         CDBV)                                                                                     •   Complete GRAS
       state-of-the-art strain                                                    antimicrobial, anti-inflammatory
       engineering lab in                                                                                                              work for CBG
       Mountain View, CA             •   Produced >99% pure CBG from
                                                                              •   Added to major cannabis ETF's (TSX: HMMJ,            (anticipated H1
                                         pilot, samples distributed to            NYSE: THCX)                                          2022) enabling
   •   Commenced trading on              prospective clients
                                                                                                                                       food & beverage
       OTC in U.S. (OTCQB: CANSF)                                             •   Presented CBG data on human skin at Society
                                     •   Raised $18 million via prospectus        for Investigative Dermatology conference
                                                                                                                                       consumer
   •   Uplisted to the TSX Main          offering to advance R&D and                                                                   products
       board (TSX: WLLW)                 commercialization efforts                Announced multiyear supply agreement for
                                                                              •
                                                                                  CBG with Cellular Goods                          •   Start to work on
                                     •   Announced it had selected CMO
                                         to commence commercialization
                                                                                                                                       other classes of
                                         of CBG in Q1 2021, six months                                                                 compounds
                                         ahead of schedule
                                                                              •   Added CBN to portfolio of cannabinoids               beyond
                                                                                                                                       cannabinoids
                                                                              •   Commenced commitment to manage
                                                                                  sustainability with formation of ESG committee

                                                                                                                                                          P A G E   1 4
appendix
Leadership

management                                                                                                technical & sales

  Trevor Peters                      Chris Savile, PHD               Travis Doupe, CPA,CA               Mathias Schuetz, PhD          Trish Choudhary, PhD              Troy Talkkari, CFA            Simon Hickling, PhD
  CEO, President &                                                                                                                    VP Research &                     VP Corporate                  SVP Business
                                     COO                             CFO                                VP Plant Science
  Director                                                                                                                            Development                       Development                   Development
  Experienced executive having        Over 15 years in science,      CPA,CA with over 18 years’         Adjunct Professor Dept of
                                      business development, and                                         Botany UBC, researcher and                                      Over 15 years’ experience     25 years’ experience in
  co-founded four start-up                                           experience as a financial                                        15 years' experience in R&D and
                                      commercial operations roles                                       plant molecular biologist                                       in the finance industry and   production and international
  companies in the past 15                                           executive, principally in start-
                                                                                                        with extensive expertise in   lab operations optimizing         was most recently a           business development in the
                                                                     up companies
                                                                                                        plant genetics and cannabis   biological processes for          Director of Institutional     pharmaceutical and biotech
  Instrumental in seven public        Highly experienced scientist                                      technology                    industrial biotech and food       Equity Sales at GMP           industry, having previously
  and private start-up                focused on the                                                                                                                    FirstEnergy                   held roles at DSM, Codexis and
  companies in the energy                                            CFO several publicly-listing       Over 14 years’ research       applications
                                      development, scale-up and      companies including most           experience and author of                                                                      PharmaZell
  industry over the past 20 years                                                                                                                                       Was part of 66 M&A
                                      commercialization of           recently, Suroco Energy Inc., a    many peer-reviewed            Highly experienced in
                                      biobased manufacturing         Canadian based, TSXV-listed        publications in prestigious                                     transactions totalling over   Proven track record of
                                                                                                                                      developing high throughput        $22 billion in value          developing mutually
  Raised over $1 billion in equity    processes                      energy company with                plant science journals
  and debt financings at various                                                                                                      microbial strain engineering                                    successful commercial
                                                                     operations in Colombia and         Numerous citations and                                          Was part of 833 financings,
  stages of corporate                 R&D and operational leader                                                                      platforms for production of                                     relationships to meet client’s
                                                                     prior Milagro Energy (TSX)         awards for research                                             including 279 as the lead
  development                         on several programs that led                                                                    commercially relevant                                           specific product needs, with a
                                                                                                        excellence                                                      dealer, totalling over $131
                                      to commercial                                                                                                                                                   focus on cutting-edge
                                                                                                                                      compounds                         billion of capital raised
  Successful transactions             manufacturing processes        Served in positions of             PhD in 2009 at Simon Fraser                                                                   technologies in highly
  totaling over $4 billion on sale                                   increasing importance at           University                                                                                    regulated markets
                                                                                                                                      Proven track record of            CFA designation and
                                                                     Sherritt Oil & Gas, including                                                                      Bachelor of Commerce in
                                      PhD in 2005 at McGill          Finance Manager & Controller                                     enabling innovative                                             Received his B.Sc. (Hons) from
  Extensive intellectual property     University                                                                                      technologies from initial         Finance from the University   Sheffield Hallam University
  and patent prosecution                                             and Controller of NAL                                                                              of British Columbia
                                                                     Resources (TSX)                                                  concept through development                                     (U.K.) and his Ph.D. from the
  background in the energy                                                                                                                                                                            University of Bath (U.K.)
  technology sector                                                                                                                   by building and leading high
                                                                     Roles with PwC in Calgary,                                       performing, multidisciplinary
                                                                     Alberta and Havana, Cuba                                         teams.

                                                                                                                                      PhD in 2008 from Macquarie
                                                                                                                                      University, NSW, Australia
                                                                                                                                                                                                                       P A G E   1 6
Leadership

diverse board of directors

  Peter Seufer-Wasserthal,         Donald Archibald                   Fotis Kalantzis, PhD                 Al Foreman                            Sadiq Lalani                        Barbara Munroe
  PhD                              Independent Director               Independent Director                 Director                              Independent Director                Independent Director
  Chairman
                                   Independent businessman with       25 years experience in oil and gas                                         25 years’ experience as Chief
  25 years of experience in the                                                                            Partner and Chief Investment                                              More than 25 years of experience as
                                   significant senior executive and   exploration and development.                                               Financial Officer of publicly-
  technology and biotechnology     board experience for numerous      Currently CEO and President of       Officer at Tuatara Capital                                                a lawyer and executive in diverse
  sector                                                                                                                                         listed issuers, including current
                                   public and private companies       Spartan Delta Corp.                                                        Vice President & CFO at Kelt        industries. Current Chair of the
                                                                                                           Previously, Managing Director at      Exploration Ltd.                    Board of Crescent Point Energy Corp
  Currently Chief Commercial                                          Co-founder and senior executive      JP Morgan in the Financial
  Officer of Sestina Bio, LLC      Director of Spartan Delta Corp.
                                   Previous director and audit        of several public companies          Sponsors Group and Private            C-Suite Energy Executive            Has served as an executive in
                                   committee member of                including Spartan Energy Corp.,      Equity Fund Services Business         Awards CFO of the Year              several customer-centric and
  Previously Chief Commercial      publicly-traded Spartan Energy     Spartan Oil Corp. and Spartan
  Officer of Origenis GmbH                                                                                                                                                           diverse industries, as EVP, Corporate
                                   Corp. and Spartan Oil Corp.        Exploration Ltd.
                                                                                                           Began his career at Citigroup,                                            Services and General Counsel for
  Previously VP, Business                                                                                  and has held executive roles at                                           WestJet Airlines Ltd., the Assistant
  Development for Intrexon         Previously President of Cypress    Holds an M.SC from the University
                                                                                                           several companies                                                         General Counsel, Upstream at
  Corporation, responsible for     Energy Corp., Chairman & CEO       of Saskatchewan and a PhD from
                                   of Cyries Energy Inc. and          the University of Alberta                                                                                      Imperial Oil Ltd., and the Senior Vice
  business development in Europe
  and Asia for four years          President & CEO of Cequel                                                                                                                         President, Legal/IP & General
                                                                                                           Holds a B.S. Finance (University of
                                   Energy Inc.                                                                                                                                       Counsel, Corporate Secretary for
                                                                      Published and presented              Connecticut) and a dual J.D./MBA
  A member of the Institute of                                        numerous papers in international                                                                               SMART Technologies Inc.
                                                                                                           (Arizona State University)
  Corporate Directors and holds    Holds a B.Comm (University of      journals and conferences
  the ICD.D designation
                                   Alberta) and MBA (University of                                                                                                                   A member of the Institute of
                                   Western Ontario)                                                                                                                                  Corporate Directors and has
  Received a Ph.D. (Technical                                                                                                                                                        extensive corporate governance
  University of Graz)
                                                                                                                                                                                     experience

                                                                                                                                                                                     Holds a Bachelor of Commerce,
                                                                                                                                                                                     Finance degree and a Bachelor of
                                                                                                                                                                                     Laws degree, both from the
                                                                                                                                                                                     University of Calgary. Admitted to
                                                                                                                                                                                     the Law Society of Alberta in 1991
                                                                                                                                                                                     and holds the ICD.D designation
                                                                                                                                                                                                                      P A G E   1 7
Disclaimer

 Forward Looking Statements. Certain information included in this presentation           viability, safety, efficacy, dosing and social acceptance of cannabinoids; the         While such information is believed to be reliable for the purpose used herein,
 constitutes forward-looking information under applicable securities legislation.        capital markets and the general economy; changes to cannabis laws and                  Willow does not assume any responsibility for the accuracy of such information.
 Forward-looking information typically contains statements with words such as            regulations in Canada, the United States and Europe; the legalization of the use       None of the sources cited in this presentation have consented to the inclusion of
 "will", "anticipate", "believe", "expect", "plan", "intend", "estimate", "propose" or   of cannabis for medical and/or adult use in jurisdictions outside of Canada;           any data from their reports, nor has Willow sought their consent.
 similar words suggesting future outcomes or statements regarding an outlook.            and applicable laws not changing in a manner that is unfavorable to the
 Forward-looking information in this presentation includes, but is not limited to,       Company.                                                                               FOFI Disclosure. This presentation contains future-oriented financial information
 statements relating to: the business, strategies, expectations, planned                                                                                                        and financial outlook information (collectively, "FOFI") concerning Willow's
 operations and future actions of Willow Biosciences Inc. ("Willow" or the               Although Willow believes that the expectations and assumptions on which the            financial position, liquidity, available funds, ability to fund commercial
 "Company"), including research and development programs at the facilities               forward-looking statements are based are reasonable, undue reliance should             production, market capitalization and components thereof, as well as FOFI
 located in British Columbia and California; the Company's ability to                    not be placed on the forward-looking statements because Willow can give no             concerning the estimated size of the global biosynthetic cannabinoid market
 commercially biosynthesize and create proprietary genomes; Willow's                     assurance that they will prove to be correct. Since forward-looking statements         (including the compound annual growth rate of the cannabinoid market), all of
 milestone projections, including the timing of commercialization of the various         address future events and conditions, by their very nature they involve inherent       which are subject to the same assumptions, risk factors, limitations and
 cannabinoids in its product portfolio; expected therapeutic benefits of Willow's        risks and uncertainties. Actual results could differ materially from those currently   qualifications as set forth in the above paragraphs. FOFI contained in this
 portfolio cannabinoids, including CBG; expected benefits and cost-savings               anticipated due to a number of factors and risks. These include, but are not           presentation was approved by management as of the date of this presentation
 resulting from commercial-scale production via the Company's fermentation               limited to, permits, licenses and regulatory and third party approvals not being       and was provided for the purpose of providing further information about
 manufacturing platform, including manufacturing performance estimates and               obtained in the manner or timing anticipated by the Company; the ability to            Willow's anticipated future business operations. Willow disclaims any intention
 forecasts; the development of Willow's intellectual property portfolio; the             implement corporate strategies; failure of counter-parties to perform                  or obligation to update or revise any FOFI contained in this presentation,
 arrangements under, and potential benefits of, its strategic partnerships;              contractual obligations; the state of domestic and international capital               whether as a result of new information, future events or otherwise, unless
 discussions with cosmetics and consumer-packaged goods entities,                        markets; risks associated with the cannabis and cannabinoid industries in              required pursuant to applicable law. Readers are cautioned that the FOFI
 manufacturing partners and other key stakeholders; the performance of the               general; infringement on intellectual property; failure to benefit from                contained in this presentation should not be used for purposes other than for
 Company's business and operations; the financial strength of the Company; the           partnerships or successfully integrate acquisitions; actions and initiatives of        which it is disclosed herein.
 ability of the Company to fund its business plan using cash on hand and                 federal and provincial governments and changes to government policies and
                                                                                         the execution and impact of these actions, initiatives and policies;                   No Offer. This presentation does not constitute an offer to sell or solicitation of
 existing resources; the size of the biosynthetic cannabinoid market, including
                                                                                         import/export and research restrictions for cannabinoid-based operations; the          an offer to buy any securities of the Company. The sole purpose of this
 potential demand for Willow's cannabinoids from the pharmaceutical,                                                                                                            presentation, in paper or electronic form, is strictly for information purposes.
 cosmetics and consumer packaged goods industries; Willow's expected                     size of the medical-use and adult-use cannabis market; competition from other
 customer-base and potential addressable markets; the competitive conditions             industry participants; and other factors more fully described from time to time
                                                                                                                                                                                U.S. Registration. This presentation is not an offer of any securities of the
 of the industry in which the Company operates and the competitive                       in the reports and filings made by the Company with securities regulatory
                                                                                                                                                                                Company for sale in the United States. The Company's securities have not been
 advantages of the Company; the performance of the current science team,                 authorities. Please refer to the Company's Annual Information Form and the             registered under the U.S. Securities Act of 1933, as amended, and may not be
 management and board and the ability to find other qualified personnel with             Management's Discussion and Analysis for additional risk factors relating to
                                                                                                                                                                                offered or sold in the United States absent registration or an exemption from
 operational experience; the Company's ESG efforts and objectives; and the               Willow, which can be accessed either on Willow's website at www.willowbio.com          registration. This presentation shall not constitute an offer to sell or the
 Company's future product offerings, including the development of other                  or under the Company's profile on www.sedar.com.
                                                                                                                                                                                solicitation of an offer to buy nor shall there be any sale of the securities in any
 cannabinoids in Willow's product portfolio and the future production levels,            Readers are cautioned that the assumptions used in the preparation of                  state in which such offer, solicitation or sale would be unlawful.
 quality, consistency and costs thereof.
                                                                                         forward-looking information, although considered reasonable at the time of
 The forward-looking statements contained in this presentation are based on              preparation, may prove to be imprecise. Willow's actual results, performance or
 certain key expectations and assumptions made by Willow, including                      achievement could differ materially from those expressed in, or implied by,
 expectations and assumptions concerning: the future operations of, and                  these forward-looking statements and accordingly there can be no assurance
 transactions completed by, the Company; the potential for strategic                     that such expectations will be realized and/or what benefits Willow will derive
 partnerships to open new and larger markets (including non-pharmaceutical               therefrom. The forward-looking information contained in this presentation is
 markets); Willow's ability to generate higher quality cannabinoids at lower costs;      made as of the date hereof and Willow undertakes no obligation to update or
 cost synergies created by its strategic partnerships and the successful                 revise any forward-looking information, whether as a result of new information,
 implementation thereof; the adequacy of current capital; the availability of and        future events or otherwise, unless required by applicable securities laws. The
 access to qualified personnel; the results of scientific research; the Company's        forward-looking information contained in this presentation is expressly qualified
 ability to protect its intellectual property; the expected growth in the                by this cautionary statement.
 biosynthetic cannabinoid market, including demand for cultured cannabinoids             Third-Party Information. Certain information contained herein has been
 from the pharmaceutical, cosmetics and consumer packaged goods
                                                                                         obtained from published sources prepared by independent industry analysts
 industries; expectations regarding the regulatory framework for cultured
                                                                                         and third-party sources (including industry publications, surveys and forecasts),
 cannabinoids; changes in prices and costs of inputs; the medical benefits,

                                                                                                                                                                                                                                                                 P A G E   1 8
THANK YOU

Trevor Peters
CEO, President & Director

Troy Talkkari, CFA
Vice President, Corporate Development

T: (403) 618-1117

E: info@willowbio.com
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