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April 2020 THE AFRICAN HEALTHCARE PORTAL COVID-19 Newsletter FEATURING Telehealth in Nigeria - 2 COVID-19 in Egypt - 4 Fear: Global response to Pandemics - 5 Digital response to COVID-19 epidemic -7 Diagnosis & management of COVID-19 -8 UPDATE FROM OUR FOUNDER Dr Yushavia Govender The world as we know it has changed - the outbreak of the Corona virus has forced us to change the way we work, spurring the need for tele-medicine, tele-psychology and tele-radiology to mention a few. It highlights the fragility of global healthcare systems and our poor preparedness for a large scale viral outbreak almost a century since the Spanish influenza. The articles featured in this newsletter provide a brief update on how COVID-19 is being managed, lessons learned and the role of technology going forward. One thing is for sure, our approach to healthcare must change if we are to overcome existing and future pandemics.
TELEHEALTH & COVID-19 IN NIGERIA Osita Aniemeka (PhD) Ambassor for Telemedicine Today Nigeria African telemedicine market has experienced substantial Telehealth growth in recent years. From $18bn 2015, it’s expected to grow into a $41bn next year. Telemedicine is a great promise for has proven to be a Africa, especially for individuals living in geographically challenged areas. With the support of SeekMed, the platform blessing to for affordable telemedicine, that helps connect patients with healthcare delivery quality international healthcare professionals via a user- friendly mobile application, Africa’s healthcare terrain has in the age of a changed tremendously. pandemic in When telemedicine arrived in Nigeria in January, 2010 via a Nigeria. pilot project at the Lagos University Teaching Hospital (LUTH), the interactive electronic mode of teaching, research and provision of medical services was embraced by lecturers, students and patients because of its efficiency and cost-savings potentials. Other colleges and universities in the country where encouraged to consider partnerships with IT companies Like other African countries, it’s the poor state of that provide telemedicine infrastructure. In Nigeria, preparedness for the pandemic in Nigeria that is creating the telemedicine employs modern technology to improve fear and anxiety as well as the doubts in the minds of many. medical education and services and is also a veritable The nation’s inadequate healthcare infrastructure is not just tool for communication between medical experts in Nigeria outmoded but also out-of-use. Nigeria’s healthcare system, and abroad. copied and never corrected was designed to bring patients together in a place – the hospital. The sick and the infected It took the new coronavirus to bring the real potentials of can only access healthcare by visiting hospitals. telehealth to the fore in Nigeria. In an unmatched approach, governments and health professionals became willing to What Nigeria seeks now is a healthcare apparatus where deploy a technology that should have happened years ago, to healthcare personnel can provide care remotely – and not only save lives but bring quality healthcare to the arguably, more competently and commendably – than in a underrepresented mass of the population. The most packed, health center. With COVID 19, Nigeria is populated nation in Africa now seeks ways and means of experimenting with the notion that some local health issues deploying new telehealth strategies as Covid-19, the new can be resolved without the revered out-patient and in-patient deadly masquerade is forcing a new dance beat, creating a approaches and in some cases with even the revered medic’s dance step. physical touch.
Genesis of a success story... Multimedia messaging was added to its list of features allowing A few years ago in Nigeria, owning and subscribers to send pictures, audio clips, and even short video operating a cell phone was an exclusive preserve of the clips to each other. EDGE also increased the speed of mobile high and mighty in government and in the private internet browsing to Dial-up speeds. All these added up to sector. Apart from the prohibitive cost of accelerate the basis for telehealth in Nigeria. With the incursions between $500 and $1000, availability was an obstacle to of COVID 19 in Nigeria, the four cardinal points for telehealth surmount. It was a matter of pride and prestige to hold success include: the handset and flaunt it to the envy of the masses plus connectivity was non-existent. 1. Stemming The Spread With telehealth, COVID 19 spread has been stemmed faster and After almost 20 years (August 2021) since the Global diagnoses made sooner. There are a handful tele-COVID System for Mobile Communication (GSM) genre of services running at the moment and it is reported that the communication was introduced into the Nigerian isolation centers who entered these services, are able to identify market, it has made its mark in Africa. GSM in the critical cases in very short time for further isolation and itself is not a new technology. It debuted in 1982 as a Pan- attention. Testing is faster and emergency care is better directed. European communication technology and had since spread beyond the frontiers of Europe to 2. Continuous Monitoring other regions, including Africa the good news is that There are some infected persons that need to be kept under despite the late entry into the GSM market, Nigeria has observation round the clock and this is where the telehealth outpaced many countries across the globe in comes handy in Nigeria. Telehealth is currently being used in a terms of market size and telephone penetration. The first lot of COVID 19 intensive care units because there, the patients GSM service rolled out in August 2001 followed a need to be monitored continuously. With the technology, the successful Digital Mobile License, DML, auction experts get a permanent eye that helps them know about conducted in January of the same year by the nation’s certain distractions, sudden changes and other important telecom regulator, the Nigerian Communications signal(s). Commission (NCC). That auction, the first in Africa, was adjudged transparent and world-class by both the 3. Bolstering Second Opinion Syndrome World Bank and the International Telecommunications Second opinion in medicine is a decision-support tool for Union (ITU). The NCC had placed the asking price for ratification or modification of a suggested treatment, by another each license at a conservative $100 million. But at the physician. During the COVID 19 pandemic, second opinion has a end of the critical influence on the testing, treatment and prognosis. A auction, each licensee paid as high as $285 million. simple phone call, a video from tele-COVID centers, etc., can provide that now. GSM technology has been the most prominent mobile phone technology in the world. Although there are other 4. Rehab at Home technologies that are competing with GSM, it’s still the When the infected recovers from the pandemic or is still being best. GSM offers a lot of possibilities to telephony in treated in the remotest parts of the country, telemedicine is Nigeria like text messaging and even low speed internet pretty useful for them. Healthcare professionals and access. Further improvements were made with the specialists have kept a check on these persons even when they are introduction of General Packet Radio Service (GPRS) and at home, which means that if and when a patient starts acting Enhanced Data Rates for GSM Evolution (EDGE) that weird, the healthcare personnel will immediately know about it extended the capabilities of GSM networks. will take help and rescue steps. Telehealth has proven to be a blessing to healthcare delivery in the age of a pandemic in Nigeria.
COVID-19 IN EGYPT ‘’Egypt is making substantial efforts to control COVID-19 outbreak. Significant work is being done‘’, Hager Ahmed & Fatma Sobh says Dr. Yvan Hutin, Director for Communicable Diseases in WHO’s Regional Office and mission team Medecins San Frontieres (MSF) lead. The Egyptian MOHP has made remarkable Egypt decisions since March, 2020, by intensifying its already effective infectious diseases surveillance system to On the 11th of March 2020, WHO announced COVID-19 define and detect suspected cases. Moreover, MOHP is a pandemic. COVID-19 has caused more than 1,000,000 establishing dedicated hospitals for COVID-19 patients, confirmed cases and above 60,000 deaths worldwide, suppling the central laboratories across Egypt with since its outbreak in Wuhan, China in December 2019. COVID-19 diagnostic tests, and providing health workers The concerns of the COVID-19 situation in Egypt were with training courses to deal with the new disease. amplifying, due to the elevated number of tourists who have visited Egypt prior to their diagnosis with COVID- Additional efforts were made to raise public awareness 19 after their return to their countries. of COVID-19 risk digitally using social media as well as on the ground through health campaigns supported by Egypt announced its first COVID-19 case several partners and volunteers. in mid-February, since then, the number of confirmed cases has exceeded 1000 cases, with more than 70 deaths The government has also taken crucial steps to limit the and it keeps rising according to the last Egyptian outbreak, through partial lockdown of the country, with ministry of health and population (MOHP) update on international flight restriction, closure of schools, work April 4th, 2020. Although, it is difficult to estimate and religious places, with the exception of vital accurately the real number of COVID-19 cases in Egypt services providers as hospitals/food supermarkets, owing to many reasons. prohibition of any public gatherings, strict curfew after 7pm and disinfecting major streets and public Firstly, the large youth population with a tendency to places. On the other hand, there is still much to be done, not show symptoms or show mild symptoms. Secondly, such as improving the referral system of cases, testing criteria was limited to travel history and contact increasing access to diagnostic tests, improving with a confirmed case. In addition, the lack of abundant, preventive measures on all levels in different sectors and rapid and cheap screening/diagnostic methods. full public integration. Each of these must to be upgraded to effectively contain the COVID-19 outbreak. Furthermore, greater attention and support for research Limiting contact has is required - A possible collaboration with the WHO to open the first Biosafety level 3 laboratory in Egypt has been key to curb the been tabled. spread, and we have To conclude, as this is a fight against a new disease, followed similar learning is ongoing and measures are adapted as new measures as other information filters through. For that, the Egyptian experience and efforts against COVID-19 outbreak are countries impressive, particularly the health sector performance, and the rapid progress they achieve determinedly.
FEAR: GLOBAL RESPONSE TO PANDEMICS Elvis Ogweno (MPH, MSc, CCP) & Tanya Gravier (MPH) Samaritan's Purse Independent Consultant Kenya USA Epidemics are hardly a novelty. They have been COVID-19 shaping, mapping, and fundamentally altering human history across the world for millennia. Infectious Infectious diseases of the lower respiratory tract, diseases have consistently threatened humans, their tuberculosis, HIV/AIDS, malaria, and diarrheal governments, and social security. African countries are diseases still represent the top causes for morbidity highly vulnerable to outbreaks which are perpetuated and mortality in African countries. by poverty, poor healthcare infrastructure, and The threat of COVID-19 is an undeniable source of unstable governance at national, state, and local levels. political and social anxiety for African countries particularly due to the severity of the disease in Unpredictable pandemics constitute black swan events individuals with underlying health conditions. Several with immense potential to severely erode market African countries have healthcare systems confidence and countries’ economic capacities, thus that are already overwhelmed by the double burden triggering crises of political faith from which it is often of both communicable and non-communicable difficult to recover. It is therefore not surprising to diseases and obstructed by gradual privatization. witness the surge of alarmism and panic in the wake of These systems would be strongly challenged by the the novel corona virus outbreak that causes the disease quarantine of even hundreds or more suspected COVID-19 which has now been elevated to pandemic COVID-19 cases. level status and has infected about 680,000 individuals worldwide, officially exceeding the Currently there are no approved vaccines or threshold of 32,000 deaths. treatments. Although several drugs are being investigated for their efficacy in treating COVID-19 Just when the World Health organization was looking infection including, an investigational drug that was forward to announcing the world is Ebola free on the originally intended to treat Ebola called remdemisvir, 12th of April, 2020, this milestone was eclipsed by the several protease inhibitors that are normally used to novel corona virus outbreak that began mid-December treat HIV, the anti-malarial drugs in Hubei Province, Wuhan, China. hydroxychloroquine and chloroquine, and the macrolide antibiotic azithromycin, and results have been encouraging, more studies and Previous epidemic experiences randomized clinical trials will be needed in order to characterized by strong determine which treatment or treatments are most multilateral coordination have effective. also helped Africa develop greater responsiveness to impeding threats
Hanta virus In addition to COVID-19, the recent report of the Access to health services is often determined by other socio- death of a man from hanta virus while riding on a economic or political factors, with poverty and insecurity crowded bus in China ignited more fear that yet being some of the greatest obstacles. These challenges will another outbreak was lurking around the corner for need to be addressed in order to keep this upward life expectancy trend. humanity. However, it is important to note that the hanta virus is not a novel disease and is transmitted to Because of these strong inequalities between countries, poor humans by mice through their saliva, urine, and faeces. healthcare infra-structure, and unstable political climates, People usually come in contact with the virus through Africa is poised to be the weakest link in global containment inhalation of contaminated dirt and dust particles efforts. Yet, the narrative about Africa’s vulnerability and while cleaning. weakness once again fails to grasp that the continent is exactly that, a continent with different political, economic, and Although an African hanta virus, also known as healthcare systems, each endowed with different levels of Sangassou virus and was identified in the rodent resilience. Africa’s fragile states are torn by conflict, political species Hylomyscus simus in Guinea of 2006, there instability, or grave poverty that are less resilient and more have been no known outbreaks in Africa to date. It is vulnerable to shocks. Other African countries have undergone not known how widespread the presence of hantavirus dramatic improvements in the development of a more robust is in Africa, and researchers screening for the presence disease surveillance and monitoring apparatus mainly because of hantavirus in South Africa also found no evidence of of the mobilization of resources and capacities during the infection out of over 2000 rodent samples tested. Ebola outbreak. Several governments already possess Infection with hanta virus is greatly feared as it may enhanced screenings and trained health workers at airports lead to the development of two serious types of which definitely contributes to strong COVID-19 response diseases in humans: Hemorrhagic fever with renal capabilities. More importantly, previous epidemic syndrome (HFRS) and cardiopulmonary syndrome. experiences characterized by strong multilateral coordination Fortunately, hantavirus cannot be transmitted from have also helped Africa develop greater responsiveness to human-to-human, therefore the risk of such an impeding threats which offers hope in the face of this outbreak in Africa is very low. pandemic. In summary, this draws attention to the prime importance of Situational analysis in Africa developing the overall resilience of African health systems. Multilateral efforts need to be sustained year-long for their Despite the high prevalence of both infectious and sheer intrinsic value, and not just in the face of rogue non-infectious diseases throughout Africa and the epidemics that are unlikely to cause as much morbidity and mortality as other more prevalent diseases in the region. And recent Ebola outbreaks in West Africa and the DRC, although there is still much to be learned about the virus that the overall average healthy life expectancy in Africa is causes COVID-19, experts evaluate it is less likely to survive in on an upward trend, increasing from 50 to 53 years the hostile warm environments of Africa than in colder between 2012 and 2015. However, there are strong regions because heat is more likely to environmentally inequalities that exist between and within countries in inactivate the virus making it less likely to spread as quickly as the African region. it has in colder climates where the virus can survive outside the body longer.
ROLE OF DIGITAL DURING COVID-19 Developers Mohini Bhavsar Digital Health Expert at Dimagi should be aware Senegal of how their COVID-19 is catapulting health systems But the question remains of whom these digital solutions may be health solutions are meant to serve. In the around Africa to further strengthen surveillance and response efforts with the development of these tools, many vulnerable excluding key populations, including women and those in help of digital solutions. Many countries are turning to local software developers, rural communities, are often overlooked. groups social enterprise technology companies, Developers should be aware of how their and even big tech partners and mobile solutions may be excluding these key groups network operators. With this influx of from accessing care due to obstacles such as actors, there are two key principles to reduced access to smartphones. Consider keep in mind when designing and alternatives to be inclusive to feature-phone developing the solutions. users, such as SMS-based platforms and the generous use of audio-visual prompts for lower After the 2014-2016 Ebola epidemic in literacy audiences. West Africa, many new technology Dimagi and many other technology providers solutions were rapidly tested and endorse the Principles for Digital Development , deployed for rapid response. In Sierra which seek to address these challenges and Leone, Guinea, and Liberia, Dimagi facilitate collaboration. These principles supported solutions for contact tracing, include designing for the user and revising and health worker training, facility readiness, improving upon existing solutions but also stock management, and diagnostic and extend to designing for scale and building for test result tracking. Other groups like sustainability. eHealth Africa stood up call center coordination centers in Sierra Leone and Next month, the World Health Organization is mass messaging campaigns led by Viamo slated to release its global resolution on Digital in the DRC. Health , which will offer guidance to health officials around the world on the selection and development of their own digital solutions. As we’re responding to the COVID-19 This guidance will echo these principles of pandemic, we have the benefit of working equity of care and sustainability while offering with proven solutions from this existing a long-term roadmap for the emerging digital library of tools. Expanding on existing ecosystem. infrastructure and proven solutions will The Africa CDC has just reported 5,287 new help us save considerable time and lives. cases on the continent. To respond effectively to this rapidly moving pandemic, we have to move quickly. Building on existing and proven solutions will help us do this. But in this effort, we cannot lose sight of our core principle to serve all people, including those who are hardest to reach.
DIAGNOSIS & MANAGEMENT OF COVID-19 Dr Rajen Morar (MBChB, FCP (SA), MMed FCCP Head of Pulmonology at Charlotte Maxeke Academic Hospital South Africa SARS-CoV-2 is a novel coronavirus identified in late The chest x-ray may be normal or may demonstrate 2019 as the cause of COVID-19 (coronavirus disease bilateral, peripheral, patchy opacities and chest. CT 2019). On March 11, 2020, the World Health chest scan (not routine) shows bilateral ground glass Organization (WHO) declared the world-wide outbreak opacities, crazy paving, and consolidation. of COVID-19 a pandemic. It has turned our world Pleural effusions are rare (5-10%). upside down. The diagnosis is confirmed by nasopharyngeal swab for SARS-CoV-2 is a single-stranded RNA virus, binds to SARS-CoV-2 reverse-transcriptase polymerase chain the (angiotensin converting enzyme 2) ACE2 reaction testing. It is important to differentiate SARS- receptor on type II pneumocytes, and spreads from CoV-2 from other circulating respiratory viruses person to person via respiratory droplets and contact. particularly influenza, where the clinical picture may be Other similar coronaviruses caused epidemics in 2002 similar. This may be significant as we approach winter [Severe Acute Respiratory Syndrome Coronavirus and influenza season in South Africa. Co-infection has (SARS-CoV)] and in 2012 [Middle East Respiratory also been reported. Syndrome coronavirus (MERSCoV)]. The reported incubation time is 3-12 days with a median duration of Infection control and isolation recommendations are viral shedding of 20 days. The attack rate is about 30- evolving and should be performed according to 40%, the reproduction number (R0) is 2.68 with a case best known practices. Empiric antibiotics are fatality rate (CFR) of between 1.5-12%. recommended for secondary bacterial infection. Corticosteroids are not recommended unless for other Patients may be asymptomatic, have mild cough to indications [e.g., asthma, COPD exacerbation, acute fulminant respiratory failure. The commonest respiratory distress syndrome (ARDS)]. Oxygen symptoms include, cough, fever, fatigue, dyspnoea, administration if patient is hypoxemic, early anosmia, sore throat and gastrointestinal (nausea, intubation and avoid aerosolization of secretions. Use vomiting, diarrhoea) symptoms. lung-protective ventilation strategies, prone and paralyze as needed. Monitor for and treat myocarditis, Laboratory abnormalities include leukopenia, cardiomyopathy and cardiogenic shock. lymphopenia and thrombocytopenia, elevated urea and creatinine, elevated transaminases, and total bilirubin. Procalcitonin is normal or low with an elevated C- reactive protein and ferritin, and elevated lactate dehydrogenase.
No specific coronavirus drugs or vaccines have proven to be effective. ACE inhibitors and angiotensin receptor blockers (ARBs) as treatments or risk factors for severity No specific of disease is speculative. coronavirus drugs Clinical trials are investigating the efficacy of drugs such or vaccines have as chloroquine or hydroxychloroquine, zinc, azithromycin, remdesivir, lopinavir/ritonavir, ribavirin, proven to be oseltamivir, tocilizumab, immunoglobulin, convalescent effective. plasma, and traditional Chinese medicine. Of interest is the Bacillus Calmette-Guérin (BCG) vaccine, which may confer some protective effect against coronaviruses. Eighty percent of patients have mild symptoms, 15% moderate, and 5% severe. Most patients deteriorate gradually with a median of 8-9 days from symptom onset to ARDS. Pregnant women and children have a better prognosis. Older age, co- morbidities including diabetes, cardiovascular disease including hypertension, and chronic lung disease, higher admission sequential organ failure assessment (SOFA) score and laboratory abnormalities such as elevated D-dimer, ferritin and troponin have been associated with worse outcomes. Hand-washing, travel restrictions, contact tracing, social and physical distancing, quarantine of suspected cases and exposed individuals are recommended to slow the rate of spread and to ‘flatten the curve’. The COVID-19 pandemic, which is a major worldwide public health emergency, poses a great threat to health, social welfare and global economy. It is heartening to see that COVID 19 has taught us respect for our common humanity with health being the basis of wealth as many nations go into ‘lockdown’.
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