Tailor Made Compounding Catalog - A4M
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Tailor Made Compounding Catalog
MEDICATION CATAL
admin@tailormadecompounding.com tailormadecompounding.com 1 859 887 0013 LOG
Table of contents Our Story....................................................................... 6 MARKETING SHEETS.................................................8 Anti-Aging Products............................................................................................... 9 Cosmeceuticals...................................................................................................... 10 Growth Hormone Products................................................................................ 11 Hair Restoration......................................................................................................13 Hormone Replacement Therapies................................................................. 14 Iontophoresis Products.......................................................................................17 Sexual Dysfunction............................................................................................. 20 Weight Loss Pack................................................................................................... 23 Weight Loss Products..........................................................................................24 MEDICATION FACT SHEETS................................. 26 3-DESOXY DHEA..................................................................................................28 AMLEXANOX.........................................................................................................29 APOMORPHINE....................................................................................................30 BUPROPION/NALTREXONE...........................................................................31 DANAZOL................................................................................................................ 32 DASATINIB/QUERCETIN.................................................................................. 33 DEXAMETHASONE IONTOPHORESIS PATCHES.................................34 ENCLOMIPHENE.................................................................................................. 35 ERGOLOID MESYLATES....................................................................................36 EXENATIDE + METHYLCOBALAMIN ......................................................... 37 GHK-Cu.....................................................................................................................38 GLYCYRRHETINIC ACID & AMINOPHYLLINE.........................................39 GONADORELIN................................................................................................... 40 HYALURONIC ACID & CHONDOROITIN...................................................41 KETAMINE...............................................................................................................42 KPV.............................................................................................................................43 MELANOTAN I....................................................................................................... 44 METFORMIN + DHEA + SERMORELIN.......................................................45 METHYLENE BLUE.............................................................................................. 46 NAD+.......................................................................................................................... 47 NANDROLONE......................................................................................................48
Table of contents (cont.) OXYTOCIN..............................................................................................................49 PENTOSAN POLYSULFATE............................................................................. 50 PTD-DBM................................................................................................................. 53 RAPAMYCIN............................................................................................................54 SCREAM CREAM................................................................................................... 55 SERMORELIN.........................................................................................................56 SERMORELIN/GLYCINE.................................................................................... 57 STANOZOLOL........................................................................................................58 TETRADECYLTHIOACETIC ACID (TTA)......................................................59 THYMOSIN ALPHA-1......................................................................................... 60 THYMOSIN BETA-4............................................................................................. 61 TRIMIX.......................................................................................................................62 VITAMIN D...............................................................................................................63 VIP.............................................................................................................................. 64 WHITENING CREAM...........................................................................................65 IV THERAPY...............................................................66 IV THERAPY PROTOCOLS...............................................................................67 IMPLEMENTING IV THERAPY IN YOUR PRACTICE............................. 74 PRICE LISTS............................................................... 77 CAPSULES & TABLETS.......................................................................................78 INJECTIONS........................................................................................................... 84 CREAMS & FOAMS...............................................................................................88 TROCHES & GUMMIES...................................................................................... 90 IV + PROTOCOLS.................................................................................................92 NASAL & EYE DROPS.........................................................................................94 SUPPLEMENTS & COSMECEUTICALS........................................................94
Our Story
Tailor Made Compounding was launched in the U.S. in January of 2016. We have
since become a major contributor to peptide medicines in the integrative health
space.
Through our compounding expertise, knowledge and experience, we have quickly
grown as one of the top compounding pharmacies in the nation. Together, with our
sister pharmacies around the world, we have established a reputation for working
closely with our physicians and are well known for obtaining difficult to source and
hard to compound pharmaceuticals. Our sister facility and first establishment,
Como compounding in Melbourne, has been working with peptide therapies for
over a decade. After witnessing the success these products were having for both
doctors and patients in Australia, we saw the demand to bring our compounding
expertise to the United States.
At Tailor Made, we pride ourselves in being partners with our practitioners and
their staff. That’s why a major part of what we do involves educating our
prescribers on the products we develop, including their clinical indications, and
dosing. Through building these relationships and creating cutting-edge peptide
therapies, we promise to maintain our status as leaders in the industry.
Collectively, all of our locations work to support the same mission; To positively
disrupt medicine using innovative technologies through education and
partnership.
4
6
Positively disrupting
medicine using
innovative technology.
7
MARKETING
SHEETS
8
6
ANTI-AGING
Anti-Aging Products
PRODUCTS
Dasatinib-
Dasatinib is a targeted therapy, classified as a signal transduction inhibitor, used to treat certain cases of
chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Dasatinib binds to and
inhibits the growth-promoting activities of SRC-family protein-tyrosine kinases, which interact with a variety
of cell-surface receptors and participate in intracellular signal transduction pathways.
Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-
associated secretory phenotype (SASP), accumulate with aging and at etiological sites in multiple chronic
diseases. Senolytics, including the combination of Dasatinib and Quercetin, selectively eliminate senescent
cells by transiently disabling pro-survival networks that defend them against their own apoptotic
environment. In the first clinical trial of senolytics, Dasatinib + Quercetin improved physical function in
patients with idiopathic pulmonary fibrosis (IPF), a fatal senescence-associated disease.
Product: Dasatinib 50mg capsule
Protocol: Take 2 capsules by mouth daily for 3 days
Rapamycin (Sirolimus)-
Rapamycin was initially discovered as an antifungal
metabolite produced by Streptomyces hygroscopicus from a
soil sample of Easter Island. This medication has been found
to possess immunosuppressive and anti-proliferative
properties in mammalian cells due to its ability to inhibit
mTOR. Rapamycin is a potent inhibitor of antigen-induced
proliferation of T cells, B cells, and antibody production.
Interest in sirolimus as an immunosuppressive therapy in
organ transplantation derives from its unique mechanism of
action, its unique side-effect profile, and its ability to synergize
with other immunosuppressive agents.Rapamycin’s
immunosuppressive and anti-proliferative properties have led
to its use in the prevention of organ transplant rejection.
mTOR has been implicated in many of the processes that are
associated with aging, including cellular senescence, immune
responses, cell stem regulation, autophagy, mitochondrial
function, and protein homeostasis (proteostasis). Furthermore, Product: Sirolimus 3mg capsule &
Rapamycin’s inhibition of mTOR has been shown to regulate Sirolimus 0.001% cream in a 30mL
cell senescence thus reducing it’s age-related pathology and Topi-CLICK®
loss of function. This will ultimately improve physiological Protocol: Take 1 capsule by mouth once
function and extend longevity. The downstream events that weekly. Apply a thin layer of cream
follow the inactivation of TOR result in the blockage of topically to the face or inner forearms
cell-cycle progression at the juncture of G1 and S phase. once daily.
Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.com 9
7
COSMECEUTICALS
Cosmeceuticals
GHK-Cu Cream
GHK-cu is a highly effective cellular signaling peptide which can increase collagen by 70% in some studies and
decreases fine lines and wrinkles by 27%. It also has other cellular signalling effects on remodeling that would
accompany the PRP well.
Benefits
• Tighten loose skin and reverse thinning of aged skin.
• Repair protective skin barrier proteins.
• Improve skin firmness, elasticity, and clarity.
• Reduce fine lines, depth of wrinkles, and improve structure of aged skin.
• Smooth rough skin
Content: 30mL Topiclick dispenser
Dosing: apply 1mL (4 clicks) daily to clean dry skin. Each click is 0.25mL. Can be applied 1mL at one time or split
as 0.5mL morning and 0.5mL evening.
GHK-Cu / Argireline / Leuphasyl Combo Cream
Building on the benefits of GHK-cu, a signaling peptide, we’ve been able to combine two botox like peptides in
this formulation. This is a beautiful adjunct to enhance in-office procedures with respect to decreasing the
contraction force of the muscles in the face. An ideal application for addressing crepiness under the eyes and
on the eyelids. These cosmeceutical peptides penetrate skin and relax muscles, causing the reduction and
softening of wrinkles and fine lines, offering a lux feel that absorbs nicely into the skin.
Content: 30mL Topiclick dispenser
Dosing: apply 1mL (4 clicks) daily to clean dry skin. Each click is 0.25mL.
Can be applied 1mL at one time or split as 0.5mL in the morning
and 0.5mL in the evening
10 Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.comGROWTH HORMONE
Growth Hormone Products
PRODUCTS
Growth hormone (GH) also known as human growth hormone (hGH) in its human form, is a peptide
hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other
animals.GH stimulates production of IGF-1 and increases the concentration of glucose and free fatty
acids.[1][2] GH is a 191-amino acid, single-chain polypeptide that is synthesized, stored and secreted
by somatotropic cells within the lateral wings of the anterior pituitary gland. When growth
hormone is released from the pituitary gland, it signals the liver to release a second hormone,
called insulin-like growth factor-1 (IGF-1). Together, growth hormone and IGF-1 tell the bones,
muscles, and other organs and tissues to grow by adding more cells
Norditropin FlexPro Pen
The FlexPro® pen is a delivery device that comes prefilled and preloaded.
5mg: $700.00 10mg: $1,300.00 15mg: $2,020.00
Did you know that GH can also help the immune system?
In mammals, the thymus supports maturation of thymocytes into T-cells and to maintain immunological
tolerance. This is an important part of what makes your immune system work.
The thymus continually atrophies after childhood, it’s epithelia is replaced by adipose tissue, and it has been
hypothesized that at least some immune dysfunction associated with aging is caused by the loss of thymus
tissue. For example, infants whose thymus was removed during cardiac surgery at 18 years after surgery have
immune cell populations more reminiscent of 65-70
year olds. Multiple factors have been tested
preclinically to try and regenerate the Thymus.
The thymic epithelia not only express GH receptors,
but secrete GH in a positive feedback loop. By using
growth hormone, you can regenerate the thymus and
prevent immunosenescence!
Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.com 11GROWTH HORMONE
PRODUCTS
Omnitrope
Ready-to-use liquid cartridge eliminates the need to reconstitute or mix
with a liquid
Injectable 5.8mg: $360.00
Saizen
Saizen is a human growth hormone produced by recombinant DNA technology
5mg vial: $789.00
Zomacton
Zomacton is a sterile, white, lyophilized powder, for
subcutaneous use, after reconstitution with the
5mg: $348.00
accompanying diluent
12 Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.comHair Restoration
HAIR RESTORATION
PTD-DBM and Valproic Acid
The Wnt/b-catenin pathway has been implicated in hair follicle development and hair
regeneration in adults. Wnt/b-catenin activators like Valproic Acid promote human hair cell
proliferation. CXXC5 is a negative regulator of the Wnt/b-catenin pathway which was upregulated
in human balding scalps. However, scientists have found a way to black this negative feedback
using PTD-DBM. This peptide, PTD-DBM, is often used as a part of larger hair protocols in
conjunction with other peptides such as GHK-Cu, Zn-Thymulin, and Thymosin Beta with
tremendous results.
Zn-thymulin
Zn-thymulin is a combination of zinc and a nonapeptide called thymulin used for hair loss. Zinc is
an essential element and serum zinc deficiency can cause hair loss,Thymulin’s activity on the hair
follicle was recently published in an in vitro study where several thymic peptides and showed
thymulin could extend the anagen phase of the hair follicle. Serum thymulin concentrations are
critically dependent on the presence of zinc. GHK-Cu is a naturally occurring copper complex that
was first identified in human plasma, but has since been found in multiple locations such as saliva
and urine. GHK-Cu has a variety of roles in the human body including promotion of wound
healing, anti-oxidant and anti-inflammatory effects, stimulating collagen synthesis in skin
fibroblasts, promoting blood vessel growth and hair follicle stimulation. The concentration of
GHK-Cu in the body decreases with age.
For hair regrowth protocols, reach out to Tailor Made Compounding. We offer two protocols for
sustainable hair growth. One incorporates PRP and microneedling while the other uses power
topical agents that produce new growth within 6-8 weeks. Before and after pictures can be sent
upon request.
PTD-DBM drops .001% 25mL dropper = $54
Valproic Acid 5% spray 25mL = $35
Zn-Thymulin/GHK-cu 10mcg/5mg/mL 25mL dropper = $47
Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.com 13HORMONE REPLACEMENT
Hormone Replacement Therapies
THERAPIES
DHEA-
DHEA is the most abundant hormone found in humans and is a precursor to many other steroids. DHEA
declines steadily as we age, and low levels of DHEA have been associated with Alzheimer’s disease, cancer,
and atherosclerotic disease. DHEA offers you an exciting option to help increase natural testosterone
production.
Pricing: Benefits of DHEA:
25mg capsule $0.53 Helps boost testosterone, aids in immune support, promotes
50mg capsule $0.63 weight loss, enhances libido, improves sports performance and
100mg capsule $0.70 muscle mass. DHEA is also thought to slow the aging process and
Suggested dosage: Take 1 combat bone density loss in women.
capsule by mouth once daily
Thyroid-
The thyroid gland secretes two hormones (triiodothyronine and thyroxine). These hormones are responsible
for regulating basal metabolic rate, neurotransmitter production and release (e.g., dopamine, serotonin,
norepinephrine), neural development, and it protects against arrhythmias (abnormal heartbeat). Many
patients with clinical or subclinical hypothyroidism may experience symptoms such as fatigue/lethargy,
depression, memory loss, anxiety, constipation, dry skin and hair, cold sensitivity, insomnia, and unexplained
weight gain or inability to lose weight. Given these factors, a combination of both T3 and T4 is often essential
for thyroid optimization. Custom liothyronine and levothyroxine compounded formulations are available in
addition to the commercial options.
Benefits of Thyroid:
Improves energy, aids in weight loss, better
tolerance to temperature changes, better sleep,
improved skin tone, decrease water retention,
normalized bowel movements, resolve body aches,
improve memory, reduce anxiety and depression.
Pricing:
Armour 15mg tablet $0.90
Armour 30mg tablet $0.90
Armour 60mg tablet $1.00
Armour 90mg tablet $1.20
Armour 120mg tablet $1.60
Armour 180mg tablet $1.60
NP 15mg tablet $0.75
NP 60mg tablet $0.75
Suggested dosage: Take 1
tablet by mouth daily
14 Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.comHORMONE REPLACEMENT
THERAPIES
Progesterone-
Progesterone is a steroid sex hormone prominently produced by
the ovaries. It is of the steroid hormone class progestogens and is Progesterone is available in
both the most abundant and important progestogen in the creams, capsules, and troches.
human body. Progesterone plays a prominent role in pregnancy,
embryonic development, and the menstrual cycle. Suggested dosage: as prescribed
by your healthcare professional.
Benefits of Progesterone:
Amplify effects of estrogen, enhance libido, improve thyroid function, neuroprotection, increase
metabolic rate to help utilize fat, improve thyroid function, reduce anxiety and upregulation on GABA,
reduce blood pressure and risk of breast cancer and help to reduce cholesterol
Testosterone- For males: Traditionally, we understand
testosterone as being responsible for the
For females: Testosterone is also vitally important for development of male tissues. It plays a
females. There are several causes of low testosterone in significant role in bone and muscle mass, body
women, often related to menopause & perimenopause. hair growth, and causes a deepened voice due
That said, women may also experience low testosterone to increased tension on the vocal cords. For
secondary to estrogen dominance, childbirth, cancer men, testosterone can reduce the risk of heart
treatment, adrenal fatigue, use of birth control pills, attack, stroke, cognitive dysfunction, sarcopenia,
depression, endometriosis, and statin drugs. For females, obesity, fatigue, depression, inflammation,
testosterone replacement therapy has been shown to cancer, diabetes, and sexual dysfunction.
increase libido, emotional well-being, muscle mass, pain
tolerance, and neurotransmitter production. Additionally,
it aids in memory retention, keeps skin from sagging, Testosterone available in creams,
reduces body fat, & maintains bone density. troches, & injections
Suggested dosage: as prescribed by your
healthcare professional
Estrogen-
Estradiol (E2) is a naturally occurring and bioidentical estrogen, or an agonist of the estrogen receptor, the
biological target of estrogens like endogenous estradiol. Due to it’s estrogenic activity, estradiol has
antigonadoptric effects and can inhibit fertility and suppress sex hormone production in both women and
men. It’s an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone
levels in women. It can be used in hormonal birth control for women and in the treatment of hormone-
sensitive cancers like prostate cancer in men and breast cancer in women, among other uses.
Estrogen combinations available in creams
(Estradiol, estriol, bi-est), tablets, or injections
Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.com 15HORMONE REPLACEMENT
THERAPIES
Enclomiphene-
Enclomiphene, an estrogen receptor antagonist, can be used in Pricing:
the treatment of male hypogonadism. Enclomiphene is a 12.5mg capsule $0.97
nonsteroidal selective estrogen receptor modulator (SERM) and 25mg capsule $1.25
acts by increasing the gonadal production of testosterone while 25mg veggie dye free capsule $1.25
stimulating FSH and LH. Enclomiphene has the potential to
improve metabolic profiles. Suggested dosage: Take 1 capsule
by mouth daily
Benefits of Enclomiphene:
Enclomiphene has been shown to increase testosterone levels while stimulating FSH and LH production.
Studies have demonstrated that enclomiphene maintains the androgenic benefit of clomiphene citrate
without the undesirable effects attributable to zuclomiphene
Oxandrolone-
Oxandrolone is a synthetic steroid, similar to the naturally occurring steroid testosterone. Oxandrolone is
indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic
infections, or severe trauma. It can also be used to offset the protein catabolism associated with prolonged
administration of corticosteroids and for the relief of bone pain frequently accompanying osteoporosis.
Pricing:
5mg capsule $3.00 Benefits of Oxandrolone:
10mg capsule $3.20 Weight gain, increased lean muscle
15mg capsule $3.20 mass, decreased bone pain in patients
20mg capsule $3.00 who suffer from osteoporosis
25mg capsule $3.20
2.5mg troche $1.00
5mg troche $1.10
Suggested dosage:
Take 1 capsule daily
16 Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.comIontophoresis Products
IONTOPHORESIS
PRODUCTS
Iontophoresis is a process of transdermal drug delivery by use of a voltage gradient on the skin. Molecules are
transported across the stratum corneum by electrophoresis and electro-osmosis and the electric field can also
increase the permeability of the skin. This can help make many molecules permeable to the skin which
previously were only available through injections. The products below are some of the most successful to be
used in when delivered as transdermal patches.
NAD+
NAD+ is the second most popular cofactor in the human body. Anti-aging therapies becoming more
mainstream as aging is now more often being viewed as a disease. Now that this transition is happening, the
ability for NAD+ to activate PARPS, Sirtuins, and help with immune dysregulation has been thoroughly
investigated and NAD+ and its precursors have been highly popularized.
The clinical importance of maintaining cellular NAD+ levels was established early in the last century with the
finding that pellagra, a disease characterized by diarrhea, dermatitis, dementia and death, could be cured with
foods containing the NAD+ precursor niacin. Additionally, cellular concentrations of NAD+ have been shown
to decrease under conditions of increased oxidative damage such as occur during aging
Altered levels of NAD+ have been found to accompany several disorders associated with increased
oxidative/free radical damage including diabetes, heart disease, age-related vascular dysfunction, ischemic
brain injury, misfolded neuronal proteins, and Alzheimer’s dementia .
Interventions targeted at restoring NAD+ have been shown in animal models to support healthy aging and
improve metabolic function, and dementia as well.
Dexamethasone
The most popular and well researched iontophoresis application is the use of dexamethasone, a
corticosteroid in a sodium phosphate solution. In this form, the drug is composed of negatively charged ions
of dexamethasone phosphate and, when loaded into a negatively charged reservoir or electrode pad, the
electrical force of the like charges pushes the medication molecules into the desired area. This causes pain
relief for many hours via direct application.
KPV
KPV is a fragment of Alpha-MSH which has shown some incredible anti-inflammatory capabilities. This is able
to be driven across the skin to help with healing, inflammatory conditions, and psoriasis.
Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.com 17IONTOPHORESIS
PRODUCTS
The following table shows some other popular uses of iontophoresis. If you
have any questions about these applications please give us a call!
Medication Principal Indication(s) Treatment Rationale Iontophoresis
Acetic acid Calcific tendinitis Acetate is believed to increase 2%–5% aqueous solution from
solubility of calcium deposits negative pole
in tendons and other soft
tissues
Calcium chloride Skeletal muscle spasms Calcium stabilizes excitable 2% aqueous solution from
membranes; appears to positive pole
decrease excitability threshold
in peripheral nerves and
skeletal muscle
Dexamethasone Inflammation Synthetic steroidal 4 mg/mL in aqueous solution
anti-inflammatory agent from negative pole
Hydrocortisone Inflammation Anti-inflammatory steroid 0.5% ointment from positive
pole
Hyaluronidase Local edema (subacute Appears to increase Reconstitute with 0.9% sodium
and chronic stage) permeability in connective chloride to provide a 150
tissue by hydrolyzing mcg/ml solution from positive
hyaluronic acid, thus pole
decreasing encapsulation and
allowing disbursement of local
edema
Iodine Adhesive capsulitis and other Iodine is a broad-spectrum 5%–10% solution or ointment
soft-tissue adhesions; antibiotic, hence its use in from negative pole
microbial infections infections, etc.; the sclerolytic
actions of iodine are not fully
understood
Lidocaine Soft-tissue pain and Local anesthetic effects 4%–5% solution or ointment
inflammation (e.g., bursitis, from positive pole
tenosynovitis)
Magnesium sulfate Skeletal muscle spasms; Muscle relaxant effect may be 2% aqueous solution or
myositis caused by decreased ointment from positive pole
excitability of the skeletal
muscle membrane and
decreased transmission at the
neuromuscular junction
Salicylates Muscle and joint pain in acute Aspirin Like drugs with 10% trolamine salicylate
and chronic conditions (e.g., analgesic and ointment or 2%–3% sodium
overuse injuries, rheumatoid anti-inflammatory effects salicylate solution from
arthritis) negative pole
Tolazoline hydrochloride Indolent cutaneous ulcers Increases local blood flow and 2% aqueous solution or
tissue healing by inhibiting ointment from positive pole
vascular smooth muscle
contraction
Zinc oxide Skin ulcers; other Zinc acts as a general 20% ointment from positive
dermatologic disorders antiseptic; may increase tissue pole
healing
18 Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.comActivaPatch®
IontoGoTM 4.0
A
INSTRUCTIONS FOR TREATMENT
1. Open pouch and remove contents: (1) ActivaPatch® IontoGoTM 4.0;
(1) alcohol wipe
2. Inspect area where ActivaPatch® IontoGoTM 4.0 is to be placed and ensure
skins intact. Clean treatment site with alcohol and wipe thoroughly.
3. Ensure that treatment site is dry before applying ActivaPatch® IontoGoTM
4.0. B
4. With a marked syringe, draw 2.0 cc of ionic solution and hydrate the active Pull
ionic solution reservoir (see diagram A).
5. Do not under- or overfill the reservoir.
6. Note: Make sure that there are no visible dry spots. If dry spots are visible,
touch up lightly with tip of syringe until they are gone (do not overfill).
7. Gently apply your thumb to the battery case and remove the pull tab to
C
activate the patch (see diagram B).
8. Peel liner and place patch directly on treatment area (see diagram C).
Do not compress the electrode on reservoir area, or solution may leak.
9. Once treatment has begun, pull off remaining release liner over pull tab
(see diagram D).
10. After 4 hours, remove patch. D
11. Properly dispose of electrode after use.
Peel
Average treatment time for 80mAmp* dosage is 4 hours.
EACH BOX CONTAINS:
x6 x6 x6
- (6) ActivaPatch® IontoGoTM 4.0
patches
ALCOHOL WIPE - (6) Alcohol Wipes
- (6) Syringes
19Sexual Dysfunction
SEXUAL
DYSFUNCTION
Wanting something beyond Tadalafil? Have you tried Apomorphine?
Whether you’re a male or female looking for a more spontaneous and natural sexual experience our novel
approach may be exactly what you’ve been looking for.
Apomorphine is a dopaminergic agonist with affinity for dopamine receptor sites, mostly D(2), within the
brain known to be involved in sexual function. It enhances normal neurological signaling in sexual response.
It stimulates dopamine receptors in the hypothalamus, causing neural signals that relax smooth muscle and
allowing erections to happen more easily.
Like Apomorphine, Tadalafil is a proven ED medication and its effects are cumulative and improve with daily
use. For females, Tadalafil orally can be effective to increase sexual desire, sexual arousal, sexual orgasm and
sexual satisfaction. It not only increases nitric oxide in the corpus cavernosum of men, but in women it also
results in the relaxation of clitoral and vaginal smooth muscle and increased blood flow in these sites, a
normal step in arousal and necessary to achieve orgasm.
Apomorphine with Tadalafil is often the perfect combination for both men and women to experience a
spontaneous and natural sexual encounter. Apomorphine is effective in 43% of men who don't respond to
tadalafil alone. Daily use allows sexual activity to happen any time, without needing to wait for a pill to start
working.
Apomorphine - 2mg troche $2.00
Tadalafil / Apomorphine - 20mg/4mg troche $4.15
Tadalafil / Apomorphine - 40mg/4mg troche $4.15
Tadalafil / Apomorphine - 20mg/6mg troche $4.15
20 Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.comSEXUAL
DYSFUNCTION
TMC Options to Overcome Sexual Dysfunction
Tadalafil
Tadalafil is a proven ED medication and its
effects are cumulative and improve with daily Available dosing:
use. It’s effective for both male and - 5mg capsule $1.25
females.Tadalafil orally can be effective to - 10mg capsule $1.50
increase sexual desire, sexual arousal, sexual - 20mg capsule $1.75
orgasm and sexual satisfaction. It not only - 6mg gummy $2.50
increases nitric oxide in the corpus
cavernosum of men, but in women it also
results in the relaxation of clitoral and vaginal - Tadalafil 40mg/oxytocin 125iu $3.00
smooth muscle and increased blood flow in - Tadalafil 10mg/oxytocin 100iu/PT-141 1000mcg troche $3.25
these sites, a normal step in arousal and - Tadalafil 10mg/oxytocin 100iu/PT-141 2000mcg troche $4.00
necessary to achieve orgasm. - Tadalafil 20mg/oxytocin 100iu/PT-141 2000mcg troche $4.50
Sildenafil
Sildenafil is used to treat men who have erectile dysfunction (also called
sexual impotence). Sildenafil belongs to a group of medicines called Available dosing:
phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an - 100mg tablet $5.00
enzyme called phosphodiesterase type-5 from working too quickly. The - 150mg troche $5.00
penis is one of the areas where this enzyme works. By controlling the
enzyme, sildenafil helps to maintain an erection after the penis is stroked.
Oxytocin
While Oxytocin certainly lives up to its reputation as the “Love
Hormone,” it also has broader applications like weight management Available dosing:
- 20 IU sublingual troche $1.00
and a performance enhancer. Oxytocin levels reach extreme levels
- 50 IU sublingual troche $1.25
during childbirth and breastfeeding, however they have also found to - 100 IU sublingual troche $1.50
be elevated during sexual arousal, skin to skin contact, and orgasm. Due - 20 IU nasal spray $67.50
to this, research has been conducted and shown that exogenous - Oxytocin drops 24iu/0.1 10ml $75.00
administration of Oxytocin can improve libido, orgasm - Oxytocin drops 100iu/0.1 10ml $100.00
intensity/frequency and sexual pleasure.
Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.com 21SEXUAL
DYSFUNCTION
PT141 NOW available in intranasal formulation
Bremelanotide PT 141 is a very exciting drug
which is frequently used by both men and
women. It works on the central nervous system
to directly induce an increase in libido and
induce erections. It works in 80% of men who
don't respond to PDE5 inhibitors and most will Available dosing:
now use it as a first line therapy. The results 10000 mcg/mL 2mL sterile injectable $115.00
with women are much less objective but there 2.5mg/0.1mL Nasal spray 3mL $150.00
is far more research showing its success. It is
FDA approved for women and is known to
increase sexual gratifying experiences by 50%.
Trimix NOW available in transdermal gel
Trimix is also used for sexual function. It is an intracavernosal three-drug
injectable prescribed medication used to treat erectile dysfunction. This
is most useful for men who cannot take oral medication or for those for
which oral medication has not been shown effective.
Available dosing:
- Alprostadil/Papaverine/Phentolamine 60mcg/30mg/3mg/mL 3mL: $50.00
Inject 0.02-0.04ml(max 0.08ml) into the base of the penis as needed for sexual activity
- Transdermal Gel: Alprostadil/Papaverine/Phentolamine 10mcg/30mg/0.5mg 5mL TopiClick® applicator $135.00
0.5ml- 1mL applied to the base of the penis 30 minutes prior to sexual activity
Scream Cream
This is a topical cream made of l-Citrulline, Aminophylline, Ergoloid Mesylate, and Pentoxifylline. The primary
mechanism of action is substantial vasodilation to the area of application which increases sensitivity. It has
been reported that only ~25% of women achieve orgasm from sexual intercourse, and even with clitoral
stimulation that number only increases to 43%. Women have reported adding Scream Cream significantly
increased libido, intensity of orgasm, and also vaginal lubrication.
Available dosing:
Citrulline 120mg/ml, Aminophylline 30mg/ml, Ergoloid Mesylate 0.5mg/ml, Pentoxifylline
50mg/ml 5mL syringe- $20.00
Dosage: Apply up to 0.5mL to clitoris 30 minutes prior to sexual activity
22 Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.comWeight Loss Pack
WEIGHT LOSS PACK
Have you heard about the NEW Sermorelin / Glycine Combo Pack?
Get to your goal faster with the TMC Weight Loss Pack
Sermorelin is a synthetic hormone peptide similar in structure to a growth hormone releasing hormone
(GHRH). It’s commonly utilized to optimize growth hormone levels in adults, offering a variable IGF-1 increase.
Sermorelin works to burn fat, increase lean muscle, improve hormonal balance, enhance energy and boost
the immune system by stimulating the production and release of hormones by the pituitary.
Glycine plays an important role in the control of hypothalamic-pituitary function, specifically impacting
growth hormone release. Glycine is an amino acid that acts as a stimulatory agent inducing the pituitary
gland to secrete hGH. Together, Sermorelin and Glycine make the ideal synergistic combination. The benefits
of Glycine go far beyond encouraging weight loss and enhancing lean muscle mass. Enjoy a better night's
sleep, less daytime fatigue, enhance mental clarity/cognition, significantly improved skin elasticity, tone and
texture, while receiving an enhanced synergistic boost to IGF1.
Product: Sermorelin 2000mcg/Glycine 5mg/mL 4mL
Protocol: 0.2mL subcutaneous injection, 5 of 7 nights a week. Taken 90
minutes after last caloric intake.
Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.com 23Weight Loss Products
WEIGHT LOSS
PRODUCTS
There are many ways to address fat loss. Some of these ways include increasing insulin
sensitivity, reducing appetite, increasing metabolism, and increasing utilization of fat stores
Below we will detail the ways each of these products can assist with fat loss.
Increasing metabolism
Sermorelin/Glycine: Sermorelin works to burn fat by stimulating the production and release of hormones by
the pituitary. Glycine plays an important role in the control of hypothalamic-pituitary function, specifically
impacting growth hormone release. Together, Sermorelin and Glycine make the ideal synergistic
combination to increase IGF1 and help your body to burn fat.
Increasing insulin sensitivity:
Amlexanox has been shown to selectively inhibit TBK1 and IKK-ε, producing reversible weight loss and
improved insulin sensitivity. It is through this mechanism that it has produced substantial results in terms of
reducing HbA1C levels and increasing insulin sensitivity.
Victoza is an analog of human GLP-1 and acts as a GLP-1 receptor agonist. Liraglutide increases intracellular
cyclic AMP (cAMP) leading to insulin release in the presence of elevated glucose
24 Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.comWEIGHT LOSS
PRODUCTS
Decreasing appetite
Oxytocin for weight management has been shown to decrease overall weight through reduced caloric consumption in
both animal and human models. Data suggests this is done by modulating the activation of hedonic food motivation
pathways. The ventral tegmental area (VTA) is one part of this pathway and the origin of dopaminergic bodies. The VTA
also has oxytocin receptors, and it is believed that saturating these receptors with exogenous oxytocin administration is
what leads to the downstream effect of decreased food desire.
Phentermine increases release of neurotransmitters which simulate metabolism and suppress appetite. Phentermine is
a “sympathomimetic” because it simulates the release and inhibition of certain neurotransmitters in your brain,
specifically dopamine and norepinephrine. Essentially it tricks your mind into feeling full
Bupropion/Naltrexone is a novel weight loss drug that combines a noradrenaline/dopamine reuptake inhibitor with a
non-selective opioid receptor antagonist. Research on the pathways that regulate food intake and body weight has
identified the hypothalamic melanocortin system and the mesolimbic reward system, which are the targets of this
combination.
Phentermine/Topiramate- Phentermine is a noradrenergic drug, which is theorized to affect food intake primarily via
the enhancement of norepinephrine release and possibly via the blockade of norepinephrine reuptake as well.
Topiramate has been shown to exhibit weight loss with a reduction in visceral body fat. Topiramate acts via modification
of excitatory voltage-activated sodium and calcium channels, antagonism AMPA/KA receptors, and enhancement of
gamma-aminobutyric acid receptor-mediated inhibitory currents. Among these actions, decreased calorie intake
appears to be a significant factor associated with topiramate-induced weight loss in humans
Increasing utilization of fat
MIC B12 L-Carnitine 25/50/50/1/50mg/ml 10mL injectable
Methionine, an essential amino acid, helps the liver breakdown fats, lowers cholesterol, relieves fatigue and helps
allergies by lowering histamine release. Inositol, a B vitamin, helps the breakdown of fats, lowers cholesterol, and helps
control mood and appetite. Choline, an essential nutrient, helps the liver breakdown fats and excrete toxins. B12, a
vitamin that boosts energy and overall metabolic rate, assists in the burning of stored body fat, helps detox, and helps
regulate sleep, mood, and appetite. The addition of L-Carnitine will assist in converting body fat to fuel and elevate
certain enzymes needed to metabolize sugars, starches, and other carbohydrates. It is used to facilitate fatty acid
oxidation, aiding in the reduction of body fat, both systemically and site specifically.
Fat Loss Cream (Aminophylline/Glycyrrhetinic acid)
Aminophylline and glycyrrhetinic acid transdermal cream is used for fat loss. Aminophylline and glycyrrhetinic prevent
cAMP breakdown. Cyclic AMP (cAMP) functions in several biochemical processes including the regulation of glycogen,
sugar, and lipid metabolism. cAMP works by activating protein kinase A (PKA) which assists in glycogen, sugar, and lipid
metabolism. Aminophylline has displayed topical fat reduction from the waist. Aminophylline and glycyrrhetinic acid
fat loss cream yields the best results through topical application.
GOAL (Glutamine, Ornithine, Arginine and Lysine)
GOAL is an amino acid blend which is commonly utilized for weight loss and endurance. Glutamine improves immunity,
aids in cellular repair, healing, and intestinal health. Ornithine helps to manage fatigue by stabilizing energy levels and
promoting better sleep. It’s utilized to reduce fatigue and improve measures of athletic performance such as speed,
strength, and power in some people. Also, taking ornithine in combination with arginine seems to improve strength and
power in male weightlifters. Arginine is known to support blood vessel tone and boost nitric oxide levels. While Lysine
together with its fatty acids helps to burn calories, thus giving the body a necessary source of energy. Lysine as an amino
acid may boost the energy levels, promote weight loss process and support the digestive system. This combination is
often the power punch patients are looking for to improve overall health while improving body composition
encouraged by improved metabolic function resulting in weight loss.
Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | admin@tailormadecompounding.com 25MEDICATION
FACT SHEETS
26Our fact sheets
contain the
following for
each product:
Description Protocol
Clinical
Research
273-DESOXY DHEA
Purity:
>98% (HPLC on request)
3-Desoxy DHEA is a competitive aromatase inhibitor for use in controlling estrogen
Molecular Formula: and increasing endogenous testosterone production. This compound is shown to
potently reduce aromatase activity through binding to the enzyme and blocking
R1=H, R2=CH3 access to endogenous estrogen precursors (androstenedione, testosterone). The
competitive inhibition offers a more short term solution to estrogen control, as
Molecular Weight: aromatase inhibition only occurs while 3-Desoxy DHEA is present in the body.
288.43 g/mol 3-Desoxy DHEA is a relatively quickly metabolized compound and has an excellent
potency with IC50 and Ki values. 3-Desoxy DHEA offers you a new option for
Sequence: estrogen control and natural testosterone elevation along with a high potency
Non-peptide coupled with better dose control.
PROTOCOL:
Content & Potency: 100mg capsules provided in a quantity of 30.
Suggested dosage: Take 1 capsule by mouth once daily.
CLINICAL RESEARCH:
What is desoxy-DHEA and How Does it Work?
Although Desoxy DHEA is an effective competitive inhibitor of aromatase it is not nearly as potent as SERMs or
other steroidal and non-steroidal suicide inhibitors. The structure- activity relationships mentioned are notcompre-
hensive as there undoubtedly exists additional structural manipulations that occur to further enhance aromatase
anity. Therefore, it is NOT an appropriate replacement to prescription compounds when heavy aromatase inhibition
is required. It does however, offer a cost-effective, safe, and legal method of estrogen management as validated by
independent lab tests and selected in vitro data. Competitive aromatase inhibition works differently than suicide
substrate inhibition, which is the mode of action through which other over the counter aromatase inhibitors such as
6-OXO and ATD work. Competitive inhibition offers a more short term solution to estrogen control, as aromatase
inhibition only occurs while Desoxy DHEA is present in the body. Desoxy DHEA is a relatively quickly metabolized
compound. So with Desoxy DHEA Tailor Made offers you a new option for estrogen control.
Ben Esgro, BS,CSCS,CIS
28AMLEXANOX
Purity:
>98% (HPLC on request)
Molecular Formula:
C16H14N2O4
Amlexanox is an anti-inflammatory and anti-allergic compound which has
Molecular Weight: traditionally been used to treat ulcers by reducing healing time and pain. It has
multiple mechanisms of action such as inhibiting inflammation by inhibiting the
298.3 g/mol release of histamine and leukotrienes. It has been shown to selectively inhibit TBK1
and IKK-ε, producing reversible weight loss and improved insulin sensitivity. It is
Sequence: through this mechanism that it has produced substantial results in terms of
Non-peptide reducing HbA1C levels and increasing insulin sensitivity.
PROTOCOL:
Content & Potency: 40mg capsules provided in a quantity of 90.
Suggested dosage: Take one capsule by mouth 3 times daily.
CLINICAL RESEARCH:
Inhibition of IKKε and TBK1 improves glucose control in a subset of patients with type 2 diabetes.
Numerous studies indicate an inflammatory link between obesity and type 2 diabetes. The inflammatory kinases
IKKε and TBK1 are elevated in obesity; their inhibition in obese mice reduces weight, insulin resistance, fatty liver
and inflammation. Here we studied amlexanox, an inhibitor of IKKε/TBK1, in a proof-of-concept randomized,
double blind, placebo-controlled study of 42 obese patients with type 2 diabetes and nonalcoholic fatty liver
disease. Treatment of patients with amlexanox produced a statistically significant reduction in Hemoglobin A1c and
fructosamine. Interestingly, a subset of drug responders also exhibited improvements in insulin sensitivity and
hepatic steatosis. This subgroup was characterized by a distinct inflammatory gene expression signature from
biopsied subcutaneous fat at baseline. They also exhibited a unique pattern of gene expression changes in response
to amlexanox, consistent with increased energy expenditure. Together, these data suggest that IKKε/TBK1 inhibitors
may be effective therapies for metabolic disease in an identifiable subset of patients.
Oral, Elif A et al. “Inhibition of IKKε and TBK1 Improves Glucose Control in a Subset of Patients
with Type 2 Diabetes.” Cell metabolism 26 1 (2017): 157-170.e7 .
29APOMORPHINE
Purity:
>98% (HPLC on request)
Molecular Formula:
C17H17NO2
Molecular Weight: Apomorphine is a dopaminergic agonist with affinity for dopamine receptor sites,
mostly D(2), within the brain known to be involved in sexual function. Apomorphine
267.32 g/mol
induces selective activation in the nucleus paraventricularis leading to erectogenic
signals. It exerts its effect on hypothalamic centres involved in the triggering of the
Sequence:
erection cascade. It dissolves rapidly and results in an erection in responders in
Non-peptide approximately 20 min.
PROTOCOL:
Content & Potency: Troche 2mg
Suggested Dosage: Dissolve 1 troche under the tongue for 15 minutes before desired effect.
CLINICAL RESEARCH:
Oral treatment of erectile dysfunction with apomorphine SL.
Apomorphine SL (Ixense, Uprima) is a new oral medication shown to be effective in the treatment of erectile
dysfunction. This compound is a dopaminergic agonist with affinity for dopamine receptor sites - mostly D(2) -
within the brain known to be involved in sexual function. Apomorphine induces selective activation in the
nucleus paraventricularis leading to erectogenic signals. More than 5,000 men with erectile dysfunction participat-
ed in phase II/III clinical trials assessing the safety and efficacy of doses ranging from 2 to 6 mg. The most favorable
risk/benefit ratio is seen with a dose-optimization regimen of 2-3 mg: the 3-mg dose provides efficacy comparable
to that of 4 mg but with fewer side effects. Consequently, review of clinical studies focuses on data with the 2- to
3-mg dose, the registered dose for use in clinical practice. The primary efficacy endpoint in most clinical trials with
apomorphine SL was the percentage of attempts resulting in erections firm enough for intercourse - one of the
most rigorous endpoints used in ED trials to date. These data were collected from both patients and their partners
by reviewing entries in patient diaries and partner BSFI questionnaires. Secondary endpoints included percentage
of attempts resulting in intercourse and improvement in ED severity based on the International Index of Erectile
Function (IIEF). The proportion of attempts resulting in erections firm enough for intercourse was 49.4% with 3 mg
compared with the baseline value of 24.3%. Partner evaluations corresponded with those of the patients. Erections
occurred between 18 and 19 min after taking apomorphine SL 2 or 3 mg. The most common side effect was nausea
which declined with continued use. Vasovagal syncope was reported inBUPROPION/NALTREXONE
Purity: Bupropion/Naltrexone is a novel weight loss drug that combines a noradrenaline/dopamine
reuptake inhibitor with a non-selective opioid receptor antagonist. Research on the pathways
>99% (HPLC on request)
that regulate food intake and body weight has identified the hypothalamic melanocortin
system and the mesolimbic reward system, which are the targets of this combination.
Molecular Formula: Pro-opiomelanocortin (POMC)-producing neurons in the hypothalamus release
Bupropion: C13H18ClNO melanocyte- stimulating hormone (MSH) and beta-endorphin. MSH mediates the anorectic
Naltrexone: C20H23NO4 effect of POMC, whereas beta-endorphin is responsible for autoinhibitory feedback, which
inactivates the anorectic effect. Bupropion can be used to stimulate the POMC neurons,
whereas naltrexone can be used to block the autoinhibitory feedback that is associated with
Molecular Weight: a decline in weight reduction. The combination’s mechanism of action might also regulate
Bupropion: 239.74 g/mol the mesolimbic reward pathways, which may lead to further weight reduction by modulating
Naltrexone: 341.4 g/mol reward values and goal-oriented behaviors. Bupropion/Naltrexone has a well-studied safety
and tolerability profile. Three long-term (56 weeks) studies have shown that patients who add
Sequence: CONTRAVE® lose approximately 2 to 4 times more weight than with diet and exercise alone.
In one study, patients who also participated in an intensive diet and exercise program for a
Non-peptide full year lost 25 pounds on average.
PROTOCOL:
Content & Potency: 180mg/12mg Capsule, 90mg/8mg Capsule, 90mg/6mg Capsule
Suggested dosage: The dosing of bupropion/naltrexone must be titrated. Starting with 90mg/6mg per day, increasing
over four weeks to 180mg/12mg twice daily
CLINICAL RESEARCH:
Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, ran-
domised, double-blind, placebo-controlled, phase 3 trial.
Despite increasing public health concerns regarding obesity, few safe and effective drug treatments are available.
Combination treatment with sustained-release naltrexone and bupropion was developed to produce
complementary actions in CNS pathways regulating body weight. The COR-I study assessed the effect of such
treatment on body weight in overweight and obese participants. 1742 participants were enrolled and randomised to
double-blind treatment (naltrexone 32 mg plus bupropion, n=583; naltrexone 16 mg plus bupropion, n=578;
placebo, n=581). 870 (50%) participants completed 56 weeks of treatment (n=296; n=284; n=290, respectively) and
1453 (83%) were included in the primary analysis (n=471; n=471; n=511). Mean change in body weight was -1.3% (SE 0.3)
in the placebo group, -6.1% (0.3) in the naltrexone 32 mg plus bupropion group (pDANAZOL
Purity:
>99% (HPLC on request)
Molecular Formula:
C22H27NO2
Danazol is a prescription medication approved to help treat endometriosis and
hereditary angioedema. It is also known to significantly decrease levels of sex
Molecular Weight:
hormone binding globulin (SHBG) and thereby increase the amount of free
337.5 g/mol testosterone. It’s thought that it does this by inhibiting the hepatic synthesis of
SHBG on a dose dependent basis and may be accentuated by endogenous
Sequence: androgen concentrations. Danazol has been shown to reduce levels of SHBG by up
Non-peptide to 80% depending on the dose administered.
PROTOCOL:
Content & Potency: 25mg, 50mg, 75mg, 100mg, 150mg capsule, 200mg capsule
50mg, 100mg, 150mg, 200mg troche
Suggested dosage: Take 1 capsule/troche by mouth every day
CLINICAL RESEARCH:
Changes in the SHBG concentration during danazol treatment.
Serum levels of sex hormone binding globulin (SHBG) were measured before and during administration of danazol
in daily doses varying between 200 and 800 mg for a period of 1-6 months. A rapid proportional decrease in SHBG
was seen at all dose levels starting within the first 24 hours and reaching statistical significance by 48 hours. After
approximately one month of treatment, the SHBG concentrations began to approach a new steady state at a level
of approximately 20-30% of the original concentration, depending on the dose of danazol. The mean proportional
reduction following a certain dose was almost identical in premenopausal and postmenopausal women. The
findings of the present investigation suggest that danazol exerts a direct inhibitory effect on the hepatic synthesis of
SHBG, which is dependent of the dose of danazol, independent of estrogen concentration, but possibly accentuated
by endogenous androgens.
Acta Obstet Gynecol Scand Suppl. 1984;123:117-23.
32DASATINIB/QUERCETIN
Purity: Dasatinib is a targeted therapy, classified as a signal transduction inhibitor, used to treat certain cases of
chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Dasatinib binds to and
>98% inhibits the growth-promoting activities of SRC-family protein-tyrosine kinases, which interact with a
variety of cell-surface receptors and participate in intracellular signal transduction pathways.
Molecular Formula:
Quercetin is a pentahydroxyflave, one of the most abundant flavonoids found in our diet. It’s beneficial
Dasatinib: C22H26ClN7O2S effects include antibacterial, anti-thrombotic, anti-inflammatory, and antineoplastic properties as well as
Quercetin: C15H10O7 acts as a protein kinase inhibitor. It is an excellent antioxidant that scavenges many naturally occurring
reactive oxygen species, including O2- and ONOO−. It also facilitates zinc trafficking into cells, which in
turn functions as an antioxidant.
Molecular Weight:
Dasatinib: 488.01 g/mol Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-
Quercetin: 302.23 g/mol associated secretory phenotype (SASP), accumulate with aging and at etiological sites in multiple chronic
diseases. Senolytics, including the combination of Dasatinib and Quercetin, selectively eliminate
Sequence: senescent cells by transiently disabling pro-survival networks that defend them against their own
apoptotic environment. In the first clinical trial of senolytics, Dasatinib + Quercetin improved physical
Non-peptide small molecule function in patients with idiopathic pulmonary fibrosis (IPF), a fatal senescence-associated disease.
PROTOCOL:
Content & Potency: Dasatinib 50mg capsule & Quercetin 250mg capsule
Suggested dosage: Dasatinib: Take 2 capsules by mouth daily for 3 days
Quercetin: Take 4 capsules by mouth daily for 3 days
CLINICAL RESEARCH:
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in
individuals with diabetic kidney disease.
Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated
secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases. Senolytics,
including the combination of Dasatinib and Quercetin (D+Q), selectively eliminate senescent cells by transiently
disabling pro-survival networks that defend them against their own apoptotic environment. In the first clinical trial
of senolytics, D + Q improved physical function in patients with idiopathic pulmonary fibrosis (IPF), a fatal senes-
cence-associated disease, but to date, no peer-reviewed study has directly demonstrated that senolytics decrease
senescent cells in humans.D + Q reduced adipose tissue senescent cell burden within 11 days, with decreases in
p16INK4A-and p21CIP1-expressing cells, cells with senescence-associated β-galactosidase activity, and adipocyte
progenitors with limited replicative potential. Adipose tissue macrophages, which are attracted, anchored, and
activated by senescent cells, and crown-like structures were decreased. Skin epidermal p16INK4A+ and p21CIP1+
cells were reduced, as were circulating SASP factors, including IL-1α, IL-6, and MMPs-9 and -12.
Hickson, LaTonya J et al. “Senolytics decrease senescent cells in humans: Preliminary report from a
clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.” EBioMedicine
vol. 47 (2019): 446-456. doi:10.1016/j.ebiom.2019.08.069
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