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2004 Respecter son sport, c'est se respecter soi-même. Livret de classification Booklet des substances Classification Substance Be true to yourself. Be true to your sport. 2004
© 2004 Canadian Centre for Ethics in Sport (CCES) Bobsleigh: CP/COA (Mike Ridewood) Cycling: CP (Kevin Frayer) Athletics: CP (Anja Niedringhaus) Alpine Ski: CP (Christian Landry) Cover Photos Pour plus de renseignements, veuillez communiquer avec : Centre canadien pour l’éthique dans le sport (CCES) 2197, promenade Riverside, bureau 202 production of this booklet. Montreal) for their assistance in the Ottawa (Ontario) K1H 7X3 (WADA-accredited laboratory in INRS-Institut Armand-Frappier 1-800-672-7775 (au Canada) ou (613) 521-3340 The CCES would like to thank the Télécopieur : (613) 521-3134 Information général - info@cces.ca Questions sur les substances - Canadian Heritage. infosubstances@cces.ca Sport Canada and the Department of support and financial contribution of The CCES gratefully acknowledges the www.cces.ca Le CCES remercie Sport Canada et le ministère du Patrimoine canadien pour www.cces.ca leur soutien et leur apport financier. substanceinquiries@cces.ca Substance information - General information - info@cces.ca Le CCES tient également à remercier l’INRS-Institut Armand-Frappier à Fax: (613) 521-3134 Montréal (laboratoire accrédité par l’AMA) de son précieux concours dans la 1-800-672-7775 (Canada-wide) or (613) 521-3340 préparation du présent document. Ottawa, Ontario K1H 7X3 2197 Riverside Drive, Suite 202 Canadian Centre for Ethics in Sport (CCES) For further information, please contact: Photos de la page couverture Ski alpin : CP (Christian Landry) Athlétisme : CP (Anja Niedringhaus) Cyclisme : CP (Kevin Frayer) Bobsleigh: CP/COA (Mike Ridewood) © 2004 Centre canadien pour l’éthique dans le sport (CCES)
Substance Classification Booklet – 2004 www.cces.ca Helping Athletes Compete Doping-Free The Canadian Centre for Ethics in Sport (CCES) promotes ethical conduct in all aspects of sport in Canada. It is a distinct privilege to be able to contribute to the value of sport in this way. Through its work the CCES seeks to ensure that sport makes a positive contribution to individuals and communities in Canadian society. To truly safeguard the value of sport however, all of us share an obligation to promote ethical values in sport. Together we have a responsibility to ensure that our sport system is one in which all Canadians can share a sense of trust, confidence, respect and pride as we pursue athletic excellence. The CCES is committed to promoting a fair and doping-free sport environment for all Canadian athletes. We believe that athletes compete because they love their sport, they respect the game and they want to achieve excellence. Collectively, Canadian athletes have called on the CCES to provide services and programs to achieve fair and ethical sport. This booklet provides athletes and their support personnel with a complete overview of the 2004 World Anti-Doping Agency (WADA) Prohibited List and its application to the Canadian Anti-Doping Program. The information in this publication is provided for reference purposes only. The prohibited categories and lists of examples in this booklet are subject to change by WADA. WADA may and does make modifications to the Prohibited List periodically. All athletes are responsible for ensuring that they comply with the rules and regulations of competition, which include any sport federation restrictions and the WADA Prohibited List. If you are in doubt about any substance or product avoid its use. The CCES provides information services to any individual or organization seeking to know whether or not a particular substance or method is prohibited for use in sport. Please note, however, that the CCES does not “clear” or “endorse” consumer products for consumption by Canadian athletes. If you are ever unsure or have any questions about a substance, please contact the CCES for further information. i
Substance Classification Booklet – 2004 www.cces.ca Table of Contents Permitted Substances . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 √ The 2004 WADA Prohibited List . . . . . . . . . . . . . . . . . . . 17 x Prohibited Substances . . . . . . . . . . . . . . . . . . . . . . . . . . 25 x TUE Therapeutic Use Exemption (TUE) . . . . . . . . . . . . . . . . . . 35 Supplements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 e Some helpful hints: • For suggestions on permitted medications, consult the Permitted Substances list. • When you’ve been prescribed a medication: 1. Verify with your physician or pharmacist that it is not in the Prohibited Substances list. 2. You should always double-check your medication by consulting the Permitted Substances list. • Please be advised that neither the Permitted nor the Prohibited Substances lists include nutritional supplements, vitamins, herbal products, etc. • Still unsure? Contact the CCES at 1-800-672-7775 or substanceinquiries@cces.ca ii
Substance Classification Booklet – 2004 Permitted Substances Permitted Substances It is important to know that most substances are not prohibited and therefore are available if needed to treat a justifiable medical condition. Substances in this category may be prescription or non-prescription medications. This list is not complete but is meant to give √ you some suggestions of what is permitted. Generic medications are often named by the abbreviation of the company followed by the chemical name of the substance. For example: Apo-, Gen-, Lin-, Novo-, Nu-, PMS-, Rho-, Rhoxal, Riva-, Scheinpharm-, and Taro-. For instance, Apo-Salbutamol is salbutamol. Please note: This list should not be taken as a recommendation concerning the relative efficacy of various substances or as a recommendation to use them. There are other permitted substances not listed here. Check with your physician, pharmacist, or the CCES for additional information. This list provides examples of permitted substances in the following categories: Acne Therapy Antispamodics Anaesthetics (local) Antivirals Analgesics/Anti-inflammatories Anxiolytics/Sedatives Antacids Contraceptives Anti-anginals Cough and Cold Preparations Antiarrhythmics Creams/Ointments/Lotions Antiasthmatics/Bronchial Anti- Decongestants inflammatories Eye/Ear Antibiotics/Antibacterials Gastric Ulcer Anticonvulsants Laxatives Antidepressants Lozenges (Throat) Antidiabetics Mania Therapy Antidiarrheals Muscle Relaxant Antifungals Premenstrual Syndrome and Antihistaminics Dysmenorrhea Antihypertensives Sedatives Anti-inflammatories Smoking Cessation Aids Antimigraine Vaginal Antinauseants/Antiemetics Other Various Medications Antiparasitic Anthelmintics Antimalarials Antiprotozoals 1
Substance Classification Booklet – 2004 Permitted Substances ACNE THERAPY Mepivacaine (Carbocaine, Polocaine) Accutane Roche (isotretinoin) Prilocaine (Citanest, Novocain) √ Acetoxyl (benzoyl peroxide) Adapalene Benoxyl (benzoyl peroxide) Prilocaine (Emla cream and patch) Ropivacaine (Naropin) Tetracaine (Ametop, Pontocaine) Benzac (benzoyl peroxide) Tetracaine (Endospray) Benzagel (benzoyl peroxide) Benzamycin (benzoyl peroxide, ANALGESICS/ANTI-INFLAMMATORIES erythromycin) 222 Tablets (ASA, codeine) Benzoyl Peroxide 642 Tablets (propoxyphene) Clindamycin 692 Tablets (propoxyphene, ASA) Clindoxyl (benzoyl peroxide, clindamycin) Abenol (acetaminophen) Dalacin T Topical Solution (clindamycin) Acetaminophen Diane-35 (cyproterone, ethinylestradiol for Acetylsalicylic acid (ASA) females only) Advil (ibuprofen) Differin (adapalene) Alka Seltzer (ASA, sodium bicarbonate, citric Erythromycin acid) Isotretinoin Alka Seltzer Morning Relief ( ASA, caffeine) Isotrex (isotretinoin) Anacin, -Extra Strength (ASA) Meted (salicylic acid, sulfur) Anaprox (naproxen) Minocycline Ansaid (flurbiprofen) Oxyderm (benzoyl peroxide) Apo-Diclo, -SR (diclofenac) Panoxyl (benzoyl peroxide) Apo-diflunisal Pernox (salicylic acid, sulfur) Apo-Etodolac (etodolac) Retisol-A (tretinoin) Apo-Keto, -E, -SR (ketoprofen) Salicylic Acid Apo-Ketorolac Sans-Acne (ethyl alcohol, erythromycin) Apo-Mefenamic Sebulex (salicylic acid, sulfur) Apo-Napro-Na, -DS (naproxen) Solugel (benzoyl peroxide) Apo-Oxaprozin Staticin (erythromycin) Apo-Sulin (sulindac) Stievamycin (erythromycin, tretinoin) Apo-Tenoxicam Sulfur Arthrotec (diclofenac, misoprostol) Tarazotene Asaphen, -EC (ASA) Tazorac (tazarotene) Aspirin, -Coated (ASA) Tetracycline Atasol plain, -8, -15, -30, codeine Tretinoin (acetaminophen) Triclosan Bextra (valdecoxib) Brexidol 20 (piroxicam) ANAESTHETICS (LOCAL) Celebrex (celecoxib) Articaine (Astracaine, Pontocaine) Coated Aspirin (ASA) Benzocaine (Endospray) Codeine Benzocaine (Auralgan, Anbesol) Codeine Contin Bupivacaine (Marcaine, Sensorcaine) Codeine Phosphate Chloroprocaine (Nesacaine-CE) Darvon-N (propoxyphene) Lidocaine (Xylocaine) Daypro (oxaprozin) Lidocaine (Emla cream and patch) Disalcid (salsalate) 2
Substance Classification Booklet – 2004 Permitted Substances Emtec-30 (acetaminophen, codeine) Ratio-Benzydamine Entrophen (ASA) Ratio-Codeine Exdol-8, -15, -30 (acetaminophen, codeine) Feldene (piroxicam) Fexicam (piroxicam) Ratio-Flurbiprofen Ratio-Indomethacin Ratio-Lenoltec N˚1, 2 & 3 (acetaminophen, √ Fiorinal (ASA, butalbital, caffeine) caffeine, codeine) Fiorinal C1/4, -C1/2 (ASA, codeine, Ratio-Lenoltec N˚4 (acetaminophen, butalbital) codeine) Froben, -SR (flurbiprofen) Rhodis, -EC, -SR (ketoprofen) Gen-nabumetone Rhoxal-nabumetone Ibuprofen Rhovail (ketoprofen) Idarac (floctafenine) Stadol NS (butorphanol) Indotec (indomethacin) Surgam, -SR (tiaprofenic acid) Mersyndol with codeine (acetaminophen, Synflex, -DS (naproxen) codeine, doxylamine) Tolectin (tolmetin) Mobicox (meloxicam) Toradol (ketorolac) Motrin, -IB (ibuprofen) Triatec-8, -8 strong (acetaminophen, MSD Enteric Coated ASA (ASA) codeine) Nalfon (fenoprofen) Triatec-30 (acetaminophen, codeine) Naprosyn (naproxen) Trilisate (choline salicylate, magnesium Naxen (naproxen) salicylate) Novasen (ASA) Tylenol plain (acetaminophen) Novo-5 ASA (ASA) Tylenol Aches and Strains (acetaminophen, Novo-Flurprofen (flurbiprofen) chlorzoxazone) Novo-Gesic C8, -C15, -C30 (acetaminophen, Tylenol Elixir with codeine (acetaminophen, caffeine, codeine) codeine) Novo-Keto, -EC (ketoprofen) Tylenol with codeine N˚1, -N˚1 Forte, -N˚2, - Novo-Methacin (indomethacin) N˚3 (acetaminophen, caffeine, codeine) Novo-Naprox, -SR, -Sodium, -Sodium DS Tylenol with codeine N˚4 (codeine, (naproxen) acetaminophen) Novo-Pirocam (piroxicam) Ultradol (Etodolac) Novo-Profen (ibuprofen) Vioxx (rofecoxib) Novo-Sundac (sulindac) Voltaren (diclofenac) Novo-Tiaprofenic Voltaren Rapide (diclofenac) Novo-Tenoxicam Novo-Tolmetin ANTACIDS Nu-Diclo, -SR (diclofenac) Amphojel (aluminum) Nu-Indo (indomethacin) Diovol (aluminum, magnesium) Nu-Naprox (naproxen) Gaviscon (aluminum, sodium) Nu-Pirox (piroxicam) Gelusil (aluminum, magnesium) Orafen (ketoprofen) Mylanta (aluminum, magnesium, Orudis SR (ketoprofen) simethicone) Oruvail (ketoprofen) Riopan (magaldrate) Phenaphen with codeine (ASA, codeine, Rolaids Antacid Tablets (magnesium, phenobarbital) calcium) Ponstan (mefenamic acid) TUMS Tablets (calcium) Pyridium (phenazopyridine) 3
Substance Classification Booklet – 2004 Permitted Substances ANTI-ANGINALS ANTIASTHMATICS/BRONCHIAL ANTI- Apo-ISDN (isosorbide 5-mononitrate) INFLAMMATORIES √ Cardizem, -SR, -CD (diltiazem) Cedocard-SR (isosorbide 5-mononitrate) Chronovera (verapamil) Accolate (zafirlukast) Aminophylline (theophylline) Apo-Cromolyn Sterules (cromolyn sodium) Diltiazem Apo-Ipravent (ipratropium) Imdur (isosorbide 5-mononitrate) Apo-oxtripylline (theophylline) Ismo (isosorbide 5-mononitrate) Apo-Theo LA (theophylline) Isoptin (verapamil) Atrovent (ipratropium) Isordil (isosorbide 5-mononitrate) Choledyl (theophylline) Minitran (nitroglycerin) Choledyl Expectorant (theophylline, Nitro-Dur (nitroglycerin) guaifenesin) Nitrolingual Pumpspray (nitroglycerin) Intal (sodium cromoglycate) Nitrong SR (nitroglycerin) Novo-Theophyl-SR (theophylline) Nitrostat (nitroglycerin) Quibron T SR (theophylline) Norvasc (amlodipine) Singulair (montelukast) Novo-Nifedin (nifedipine) Theo-Bronc (theophylline, guaifenesin, Novo-Veramil, SR (verapamil) mepyramine) Nu-Diltiaz, -CD (diltiazem) Theochron SR (theophylline) Nu-Nifed (nifedipine) Theo-Dur (theophylline) Nu-Verap (verapamil) Theolair, -SR (theophylline) Transderm-Nitro (nitroglycerine) Theophylline Tilade (nedocromil) ANTIARRHYTHMICS Vaponefrin (epinephrine) Adenocard (adenosine) Amiodarone Hydrochloride for I.V. infusion ANTIBIOTICS/ANTIBACTERIALS Apo-Procainamide * All antibiotics are permitted Apo-Quinidine Ampicillin Biquin Durules (quinidine) Apo-Amoxi (amoxicillin) Bretylium Tosylate Injection USP Apo-Amoxi-Clav (amoxillin/clavulanate Cardioquin (quinidine) potassium) Cardizem injectable (diltiazem) Apo-Ampi (ampicillin) Cordarone (amiodarone) Apo-Cefaclor (cefaclor) Isoptin (verapamil) Apo-Cefadroxil Mexitil (mexiletine) Apo-Cephalex (cephalexin) Novo-Mexiletine Apo-Cloxi (cloxacillin) Novo-Veramil, -SR (verapamil) Apo-Cefuroxime Nu-Verap (verapamil) Apo-Doxy (doxycycline) Procan (procainamide) Apo-Erythro-Base, -EC,-S,-ES Pronestyl, -SR (procainamide) (erythromycin) Quinidine Apo-Metronidazole Ratio- Amiodarone Apo-Nitrofurantoin Rythmodan, -LA (disopyramide) Apo-Norflox (norfloxacin) Rythmol (propafenone) Apo-Oflox (ofloxacin) Tambocor (flecainide) Apo-Pen VK (penicillin) Apo-Sulfatrim (trimethoprim, 4
Substance Classification Booklet – 2004 Permitted Substances sulfamethoxazole) Mandelamine (methamine) Apo-Trimethoprim Maxipime (cefepime) Apo-Tetra (tetracycline) Avlosulfon (dapsone) Bacitracin Mefoxin (cefoxitin) Merrem (meropenem) Metronidazole Injection √ Biaxin (clarithromycin) Minocin (minocycline) Ceclor (cefaclor) Mycobutin (rifabutin) Cefazolin Mycostatin (nystatin) Cefizox (ceftizoxime) Nadopen-V (penicillin) Cefotan (cefotetan) Nebcin (tobramycin) Cefoxitin Neg Gram (nalidixic acid) Ceftin (cefuroxime axetil) Nemasol Sodium Ceptaz (ceftazidime) Netromycin (Netilmicin Sulfate) Ceporacin (cephalothin) Noroxin (norfloxacin) Chloromycetin injection (cloramphenicol) Novamoxin (amoxicillin) Ciloxan (ciprofloxazin) Novo-Furatoin (nitrofurantoin) Claforan (cefotaxime) Novo-Lexin (cephalexin) Clavulin (amoxicillin/clavulanate potassium) Novo-Pen-VK (penicillin) Cloxacillin Novo-Rythro Encap (erythromycin) Coly-Mycin (sodium colistimethate) Novo-Trimel (trimethoprim, Coptin (sulfadiazine, trimethoprim) sulfamethoxazole) Crystapen (penicillin) Nu-tetra (tetracycline) Dalacin (clindamycin) Nyaderm (nystatin) Declomycin (demeclocycline) PCE (erythromycin) Doxycin (doxycycline) Penicillin Doxytec (doxycycline) Penglobe (bacampicillin) Duricef (cefadroxil) Pipracil (piperacillin) EES (erythromycin) PMS-Polytrimethoprim (trimethoprim, Erybid (erythromycin) sulfamethoxazole) Eryc (erythromycin) Pondocillin (pivampicillin) Erythrocin, -IV (erythromycin) Primaxin (imipenem, cilastatin) Erythromid (erythromycin) PVF K (penicillin) Florazole (metronidazole) Rocephin (ceftriaxone) Floxin (ofloxacin) Rovamycine (spiramycin) Fortaz (ceftazidime) Selexid (pivmecillinam) Fucidin, -IV (sodium fusidate) Septra-DS, -Injection (polymyxin, Garamycin Parental (gentamicin) trimethoprim) Gentamycin Injection USP SSD (silver sulfadiazine) Gentamycin Sulfate Injection Streptomycin Sulfate Humatin (paromonycin) Suprax (cefexime) Keflex (cephalexin hydrochloride) Synercid (quinupristin, dalfopristin) Kefurox (cefuroxime) Tazidime (ceftazidine) Kefzol (cefazolin) Tazocin (piperacillin, tazobactam) Levaquin (levofloxacin) Timentin (ticarcillin) Lincocin (lincomycin) Tobramycin sulfate injection USP Macrobid (nitrofurantoin) Zithromax (azithromycin) Macrodantin (nitrofurantoin) Z-Pak (zithromax, azithromycin) 5
Substance Classification Booklet – 2004 Permitted Substances ANTICONVULSANTS Luvox (fluvoxamine) Apo-Carbamazepine Manerix (moclobemide) √ Apo-Clonazepam Apo-Divalproex Apo-Gabapentin Nardil (phenelzine) Norpramin (desipramine) Norventyl (nortriptyline) Apo-Primidone Novo-Maprotiline Celontin (methsuximide) Novo-Tripramine (trimipramine) Clonapam (clonazepam) Parnate (tranylcypromine) Depakene (valproic acid) Paxil (paroxetine) Dilantin (phenytoin) Prozac (fluoxetine) Epival (valproic acid) Rhotrimine (trimipramine) Epiject I.V. (valproic acid) Risperdal (risperidone) Frisium (clobazam) Seroquel (quetiapine) Lamictal (lamotrigine) Sinequan (doxepin) Mysoline (primidone) Surmontil (trimipramine) Neurontin (gabapentin) Tofranil (imipramine) Novo-Carbamaz (carbamazepine) Triavil (amitriptyline, perphenazine) Phenobarbital Triptil (protriptyline) Ratio-Valproic (valproic acid) Wellbutrin-SR (bupropion) Tegretol (carbamazepine) Zoloft (sertraline) Valium Zarontin (ethosuximide) ANTIDIABETICS Albert Glyburine ANTIDEPRESSANTS Avandia (rosiglitazone) Amineptine Diabinese (chlorpropamide) Anafranil (clomipramine) DiaBeta (glyburide) Apo-Amitriptyline Diamicron (gliclazide) Apo-Clomipramine Euglucon (glyburide) Apo-Desipramine GlucoNorm (repaglinide) Apo-Doxepin Glucophage (metformin) Apo-Fluoxetine Prandase (acarbose) Apo-Fluvoxamine Sulfonylureas (chlorpropamide, gliclazide, Apo-Imipramine glimepiride, glyburide, tolbutamide) Apo-Moclobemide Apo-Nortriptyline ANTIDIARRHEALS Apo-Sertraline DDAVP (desmopressin acetate) Apo-Trazodone Gastrolytes (electrolytes, dextrose) Apo-Trimip (trimipramine) Imodium (loperamide) Asendin (amoxapine) Imodium Advanced (loperamide, Aventyl (nortriptyline) simethicone) Celexa (citalopram hydrobromide) Kaopectate (attapulgite) Desyrel (trazodone) Lomotil (diphenoxylate) Effexor, -XR (venlafaxine) Loperacap (loperamide) Elavil (amitriptyline) Maalox (aluminum, magnesium, Etafron (amitriptyline, perphenazine) simethicone) Ludiomil (maprotiline) Pepto Bismol (bismuth subsalicylate) 6
Substance Classification Booklet – 2004 Permitted Substances ANTIFUNGALS (acetaminophen, diphenhydramine, Antibiotics pseudoephedrine) Apo-Fluconazole Apo-Ketoconazole Benadryl Extra Strength Nightime (diphenhydramine) Brompheniramine √ Candistatin (nystatin) Canesten (clotrimazole) Caladryl (calamine, diphenhydramine) Dequadin Oral Paint (dequalinium) Calmylin nº4 (dextromethorphan, Diflucan, –150 (fluconazole) diphenhydramine) Ecostatin (econazole) Chlorpheniramine Fulvicin U/F (griseofulvin) Chlor-Tripolon (chlorpheniramine) Fungizone (amphotericin) Chlor-Tripolon Decongestant Lamisil (terbinafine) (chlorpheniramine, pseudoephedrine) Loprox (ciclopirox) Chlor-Tripolon ND (loratidine, Micatin (miconazole) pseudoephedrine) Monistat (miconazole) Claritin plain (loratadine) Mycostatin (nystatin) Claritin Extra (loratidine, pseudoephedrine) Nilstat (nystatin) Claritin Liberator (loratidine, Nizoral (ketoconazole) pseudoephedrine) Nyaderm (nystatin) Coricidin (chlorpheniramine, ASA) Oxizole (oxiconazole) Diphenhydramine Ratio-Nystatin Dristan, Extra Strength (acetaminophen, Sporanox (itraconazole) pheniramine, phenylephrine) Trosyd AF, -J (tioconazole) Drixoral (dexbrompheniramine, ZeaSORB (chloroxylone) pseudoephedrine) ZeaSORB AF (tolnaftate) Emadine (emedastine) Epinephrine Epipen (epinephrine) ANTIHISTAMINICS Loratidine See also Cough and Cold Preparations and Optimine (azatadine) Decongestants Panectyl (trimeprazine) Actifed Tablets (triprolidine, Periactin (cyproheptadine) pseudoephedrine) Phenergan tablets (prometazine) Adrenalin (epinephrine) Polaramine (dexchlorpheniramine) Aerius (desloratadine) Promethazine Hydrochloride Injection USP Albalon-A Liquidfilm (antazoline, Reactine (cetirizine) naphazoline) Sinutab Sinus and Allergy, Extra Strength Allegra 12h, 24h (fexofenadine) (acetaminophen, chlorpheniramine, Allegra D (fexofenadine, pseudoephedrine) pseudoephedrine) Allernix (diphenhydramine) Vaponefrin (epinephrine) Allerdyl (diphenhydramine) Zaditen (ketotifen) Apo-Cetirizine Zyrtec (cetirizine) Apo-Loratadine Atarax (hydroxyzine) ANTIHYPERTENSIVES Benadryl (diphenhydramine) Adalat (nifedipine) Benadryl Allergy/Sinus/Headache Altace (ramipril) 7
Substance Classification Booklet – 2004 Permitted Substances Apo-Clonidine Indocid P.D.A. (indomethacine) Apo-Diltiaz Indocin (indomethacine) √ Apo-Hydralazine Apo-Methyldopa Apo-Nifed PA (nifedipine) Mesasal (ASA enteric coated) Pentasa (5-ASA) Plaquenil (hydroxychloroquine) Apo-Verap (verapamil) Quintasa (5-ASA) Apresoline (hydralazine) Ratio-Sulfasalazine Atacand (candesartan cilexetil) Relafen (nabumetone) Avapro (irbesartan) Salazopyrin, En-Tabs (sulfasalazine) Capoten (captopril) Salofalk (5-ASA) Catapres (clonidine) Chronovera (verapamil) ANTIMIGRAINE Coversyl (perindopril) Amerge (naratriptan) Cozaar (losartan) Cafergot, -PB (belladonna) Diovan (valsartan) Dihydroergotamine (DHE) Hyperstat IV Injection (diazoxide) Ergodryl (ergotamine) Inhibace (cilazapril) Ergomar (ergotamine) Isoptin (verapamil) Fiorinal (ASA, butalbital) Loniten (minoxidil) Fiorinal –C1/4, -C1/2 (ASA, codeine, Lotensin (benazepril) butalbital) Mavik (trandolapril) Gravergol (ergotamine, dimenhydramine) Micardis (telmisartan) Imitrex (sumatriptan) Minipress (prazosin) Maxalt, -RPD (rizatriptan) Monopril (fosinopril) Megral (ergotamine, cyclizine) Nifedipine PA Migranal (dihydroergotamine) Nipride (sodium nitroprusside) Ratio-Tecnal (ASA, butalbital) Novo-Hylazin (hydralazine) Ratio-Tecnal –C1/4, -C1/2 (ASA, butalbital, Novo-Veramil, -SR (verapamil) codeine) Nu-Capto (captopril) Sandomigran, -DS (pizotifen) Nu-Diltiaz-CD (diltiazem) Sansert (methylsergide) Nu-Hydral (hydralazine) Trianal –C1/4, -C1/2 (ASA, codeine, Nu-Prazo (prazosin) butalbital) Nu-Verap (verapamil) Zomig (zolmitriptan) Plendil (felodipine) Prinivil (lisinopril) Ratio-Captopril ANTINAUSEANTS/ANTIEMETICS Verelan (verapamil) Anzemet (dolasetron) Zestril (lisinopril) Apo-Dimenhydrinate Apo-Metoclop (metoclopramide) ANTI-INFLAMMATORIES Biltricide (prazinquantel) Bonamine (meclizine) (All non-steroidal anti-inflammatories are Cesamet (nabilone) permitted) Dimenhydrinate (suppositories, injection) Apo-Nabumetone Dimenhydrinate Injection, -USP Apo-Phenylbutazone Gravol (dimenhydrinate) Asacol (5-ASA) Kytril (granisetron) Dipentum (olsalazine) Metoclopramide Hydrochloride Injection 8
Substance Classification Booklet – 2004 Permitted Substances Metoclopramide Omega Injection DPT Polio Vermox (mebendazole) DT Polio Zofran, -ODT (odansetron) ANTIPARASITIC Famvir (famciclovir) Flu vaccine Herplex-D (idoxuridine) √ Immunization Injections (Hepatitis, typhoid, ANTHELMINTICS tetanus) Combantrin (pyrantel pamoate) Relenza (zanamivir) Entacyl (piperazine) Symmetrel (amantadine) Tamiflu (oseltamivir) ANTIMALARIALS Twinrix Aralen (chloroquine) Valtrex (valacyclovir) Daraprim (pyrimethamine) Virazole (ribavirin) Lariam (mefloquine) Zovirax Oral (acyclovir) Malarone (atovaquone) Paludrine (proguanil) ANXIOLYTICS/SEDATIVES Plaquenil (hydroxychloroquine) Primaquine Apo-Buspirone Quinine Sulfate Apo-Chlorax (chlordiazepoxide) Apo-Clorazepate ANTIPROTOZOALS Apo-Diazepam Flagyl (metronidazole) Apo-Hydroxyzine Florazole (metronidazole) Apo-Lorazepam Mepron (atovaquone) Atarax (hydroxyzine) Pentacarinat (pentamidine) Ativan (lorazepam) BuSpar (buspirone) Buspirex (buspirone) ANTISPAMODICS Bustab (buspirone) Albert Oxybutynin Diazemuls (diazepam) Apo-Oxybutynin Imovane (zopiclone) Apo-Trihex (trihexyphenidyl) Librax (chlordiazepoxide) Bentylol (dicyclomine) Ratio-Alprazolams Buscopan (hyoscine) Serax (oxazepam) Detrol (tolterodine) Valium Roche Oral (diazepam) Ditropan (oxybutynin) Formulex (dicyclomine) CONTRACEPTIVES Kemadrin (procyclidine) Levsin (hyoscyamine) All oral contraceptives, as well as the Depo- Lomine (dicyclomine) Provera injection, are permitted in females. Oxybutyn (oxybutynin) Unidet (tolterodine-tartrate) Urispas (flavoxate) COUGH AND COLD PREPARATIONS See also Antihistaminics, Decongestants ANTIVIRALS and Lozenges Acyclovir Balminil Codeine + Decongestant + Combivir (lamivudine, zidovudine) Expectorant (codeine, guaifenesin, Cytovene (ganciclovir) pseudoephedrine) 9
Substance Classification Booklet – 2004 Permitted Substances Balminil Codeine Night-Time + Expectorant Dimetane Expectorant-C (brompheniramine, (codeine, diphenhydramine, ammonium codeine, guaifenesin, phenylephrine) √ chloride) Balminil Cough & Flu (acetaminophen, dextromethorphan, guaifenesin, Dimetapp Cold Liquid (brompheniramine, phenylephrine) Dimetapp-C Syrup (brompheniramine, pseudoephedrine) codeine, phenylephrine) Balminil DM (dextromethorphan) Dimetapp Cough & Congestion Liquid Balminil DM + Decongestant (dextromethorphan, guaifenesin, (dextromethorphan, pseudoephedrine) pseudoephedrine) Balminil DM + Expectorant Dimetapp Daytime Cold, Extra Strength (dextromethorphan, guaifenesin) (acetaminophen, pseudoephedrine) Balminil DM + Decongestant + Expectorant Dimetapp DM Cough & Cold Liquid (dextromethorphan, guaifenesin, (brompheniramine, dextromethorphan, pseudoephedrine) phenylephrine) Balminil Expectorant (guaifenesin) Dimetapp Nighttime Cold, Extra Strength Benylin 4 Flu (acetaminophen, (acetaminophen, chlorpheniramine, dextromethorphan, guaifenesin, phenylephrine) pseudoephedrine) Formula 44 D (dextromethorphan, Benylin DM (dextromethorphan) pseudoephedrine) Benylin DM-D (dextromethorphan, Guaifenesin pseudoephedrine) Hycodan (hydrocodone) Benylin DM-D-E, Extra Strength Hycomine, -S (hydrocodone, phenylephrine) (dextromethorphan, guaifenesin, Hydrocodone pseudoephedrine) Koffex DM (dextromethorphan) Benylin DM-E, Extra Strength Neo Citran, Extra Strength (acetaminophen, (dextromethorphan, guaifenesin) pheniramine, phenylephrine) Benylin E Extra Strength (guaifenesin) Neo Tuss (chlorpheniramine, Benylin First Defense (ecchinacea, menthol) dextromethorphan, guaifenesin, Buckley’s Cough, Cold & Flu Daytime Relief phenylephrine) Extra Strength (acetaminophen, Novahistex DH (hydrocodone, dextromethorphan, pseudoephedrine) phenylephrine) Buckley’s DM (dextromethorphan, Phenylephrine pseudoephedrine) Pseudoephedrine Calmylin with Codeine (codeine, Ratio-Coristex DH (phenylephrine, guaifenesin, pseudoephedrine) hydrocodone) Cheracol (codeine, guaifenesin) Ratio Cotridin (tripolidine, pseudoephedrine, Codeine codeine) Codeine Phosphate Ratio Cotridin Expextorant (tripolidine, Contac Cough, Cold & Flu Day pseudoephedrine, codeine, guaifenesin) (acetaminophen, dextromethorphan, Robitussin, Extra Strength (guaifenesin) pseudoephedrine) Robitussin AC (codeine, guaifenesin, Contac Head & Chest Congestion pheniramine) (guaifenesin, pseudoephedrine) Robitussin Honey Cough & Cold Dayquil (acetaminophen, dextromethorphan, (dextromethorphan, pseudoephedrine) pseudoephedrine) Robitussin Honey Cough DM Delsym (dextromethorphan) (dextromethorphan) Dextromethorphan Robitussin Honey Flu (acetaminophen, 10
Substance Classification Booklet – 2004 Permitted Substances dextromethorphan, pseudoephedrine) Strength (acetaminophen, Robitussin Cough & Cold, Liqui-Gels, Extra chlorpheniramine, dextromethorphan, Strength (dextromethorphan, guaifenesin, pseudoephedrine) Robitussin Cough, Cold & Flu Liqui-Gels pseudoephedrine) Tylenol Cold Caplets –chest congestion (acetaminophen, dextromethorphan, √ (acetaminophen, dextromethorphan, guaifenesin, pseudoephedrine) guaifenesin, pseudoephedrine) Tylenol Cough (acetaminophen, Robitussin DM, Extra Strength dextromethorphan) (dextromethorphan, guaifenesin) Tylenol Decongestant (acetaminophen, Sinutab Sinus Non Drowsy (acetaminophen, pseudoephedrine) pseudoephedrine) Tylenol Flu (acetaminophen, Sudafed Cold & Cough Extra Strength dextromethorphan, pseudoephedrine) (acetaminophen, dextromethorphan, pseudoephedrine) CREAMS/OINTMENTS/LOTIONS Sudafed Cold & Flu (acetaminophen, Bengay Arthritis Extra Strength (methyl dextromethorphan, guaifenesin, salicylate, menthol) pseudoephedrine) Bengay Ice Extra Strength (menthol) Sudafed Head Cold & Sinus Extra Strength Bengay Muscle Pain Regular Strength (acetaminophen, pseudoephedrine) (methyl salicylate, menthol) Triaminic Cold & Cough (chlorpheniramine, Bengay Muscle Pain Ultra Strength (methyl dextromethorphan, pseudoephedrine) salicylate, menthol,camphor) Triaminic Cold, Cough & Fever Clotrimaderm (clotrimazole) (acetaminophen, chlorpheniramine, Dermatix Fitocream (extract of T. vulgare) dextromethorphan, pseudoephedrine) Dermatix Si Gel ( polyliloxane, silicone Triaminic Cold & Night Time Cough dioxide) (chlorpheniramine, dextromethorphan, Fucidin (fusidic acid) pseudoephedrine) Garamycin Topical Preparations Triaminic Cough & Congestion Gentamycin Sulfate (dextromethorphan, pseudoephedrine) Ketoderm (ketokonazole) Triaminic Cough & Sore Throat Lidosporin Cream (polymyxin B, gramicidin, (acetaminophen, dextromethorphan, lidocaine) pseudoephedrine) MetroCream (metronidazole) Triaminic Softchews Cold & Cough MetroGel (metronidazole) (chlorpheniramine, dextromethorphan, Myoflex (triethanolamine salicylate) pseudoephedrine) Neosporin Ointment (polymyxin B) Triaminic Softchews Throat Pain & Cough Neotopic (polymyxin B, neomycin) (acetaminophen, dextromethorphan, Noritate (metronidazole) pseudoephedrine) Ozonol Preparations (Polymyxin B sulphate, Triaminic Vapor Patch (camphor, menthol, bacitracin, lidocaine) eucalyptus oil) Pennsaid (diclofenac) Tylenol Cold Caplets (Daytime), - Extra Polysporin Preparations (polymyxin B, Strength (acetaminophen, gramicidin or bacitracin) dextromethorphan, pseudoephedrine) Polysporin Plus Pain Relief Cream Tylenol Cold & Flu Nightime Relief (polymyxin B, gramicidin, lidocaine) (acetaminophen, chlorpheniramine, Prevex (petrolatum) dextromethorphan, pseudoephedrine) Ratio-Gentamicin Tylenol Cold Caplets Nighttime, Extra 11
Substance Classification Booklet – 2004 Permitted Substances Sarna-P (pramoxine) Vicks Sinez decongestant (oxymetazoline) Spectro Gram “2” (chlorhexidine) Xylometazoline √ Sun-Benz (benzydamine) Tantum (benzydamine) Teejel (choline salicylate) Zincfrin –A (antazoline, naphazoline) Zincfrin (phenylephrine) Zovirax Cream, Ointment (acyclovir) EYE/EAR Alcomicin (gentamycin) DECONGESTANTS Alocril (nedocrimil sodium) See also Antihistaminics and Cough and Alomide (lodoxamide) Cold Preparations Auralgan (antipyrine, benzocaine) Cetamide (sulfacetamide) Advil Cold and Sinus (ibuprofen, Cromolyn pseudoephedrine) Diochloram (chloramphenicol) Apo-Cromolyn Nasal Spray Diogent Ointment solution (gentamycin) Buckley’s Sinus pain relief (acetaminophen, Diomycin (erythromycin) pseudoephedrine) Diopentolate (cyclopentolate) Dayquil Sinus and Pain Relief Diophenyl-T (phenylephrine, tropicamide) (acetaminophen, pseudoephedrine) Diosulf (sulfacetamide) Decongestant Nasal Mist/Spray Diotrope (tropicamide) (xylometazoline) Duratears Naturale Dristan Long Lasting Nasal Mist/Spray Erythromycin (oxymetazoline) Eyestil (sodium hyaluronate) Dristan Nasal Mist/Spray, Mentholated Eye-Stream (salt solution) (pheniramine, phenylephrine) Garamycin Opthalmic Otic Prep. Dristan ND, Extra Strength (acetaminophen, (gentamicin) pseudoephedrine) Garasone Ophtalmic/Otic Prep. (gentamicin) Dristan Sinus (ibuprofen, pseudoephedrine) Garatec (gentamicin) Drixoral Decongestant Nasal Spray Gentamicin Sulfate (oxymetazoline) Genteal Livostin Nasal Spray (levocabastine) Hypotears Eye Ointment Mydfrin (phenylephrine) Hypotears Ophthalmic S/L Neo Citran Extra Strength Sinus Isopto Tears (acetaminophen, phenylephrine) Lacrinorm Otrivin Decongestant Nose Drops/Nasal Lidosporin Ear Drops Spray (xylometazoline) Lid-Pack Pseudoephedrine Liquifilm Tears Rhinaris Lubricating (polyethylene, Livostin Eye Drops (levocabastine) propylene) Naphcon (naphazoline) Rhinaris Saline Solution (sodium) Naphcon-A (naphazoline, pheniramine) Salinex Naphcon Forte (naphazoline) Salinol Neosporin Preparations (polymyxin B) Secaris (carbowax, propylene) Noroxin Ophtalmic Solution (norfloxaxin) Sudafed Decongestant (pseudoephedrine) Ocufen (flurbiprofen) Tylenol Decongestant (acetaminophen, Ocuflox (ofloxacin) pseudoephedrine) Opticrom (sodium cromoglycate) Tylenol Sinus, Extra Strength Optimyxin, -Plus (polymyxin B) (acetaminophen, pseudoephedrine) 12
Substance Classification Booklet – 2004 Permitted Substances Patanol (olopatadine) Zantac (ranitidine) Pentamycetin (chloramphenicol) PMS-Tobramycin Polycidin Eye/Ear Drops (polymyxin B, gramicidin) LAXATIVES Apo-Bisacodyl √ Colace (docusate sodium) Polycidin Ophtalimic Ointment (polymyxin B, Dulcolax (bisacodyl) bacitracin) Duphalac (lactulose crystals) Polysporin (antibiotic) Ex-lax (sennosides) Polytrim (trimethoprim, polymyxin B) Glycerin suppositories Refresh Plus Tears Klean-Prep Sodium Sulamyd (sulfacetamide) Lansoÿl (mineral oil) Tobramycin Maalox (aluminum, magnesium, Tobrex (tobramycin) simethicone) Tomycine (tobramycin) Metamucil (psyllium hydrophilic) Vasocon (naphazoline) Normacol (sterculia) Visine Allergy Eye Drops (tetrahydrozoline, Novo-Mucilax (plantago seed) zinc sulfate) Peri-Colace (docusate) Voltaren Optha (diclofenac) Phosphates Solution VoSol (benzethonium chloride) PMS-Sennosides Senokot Preparation (sennosides) GASTRIC ULCER Apo-Cimetidine LOZENGES (THROAT) Apo-Nizatidine Antiseptic Throat Lozenges (hexylresorcinol) Apo-Ranitidine Bentasil Lozenges (anethole, menthol, Axid (nizatidine) eucalyptus) Carafate (sucralfate) Benylin First Defense (Echinacea, menthol) Glycopyrrolate Bradosol (4-hexylresorcinol) Losec (omeprazole) Cepacol (cetylpyridinium) Losec 1-2-3-A (omeprazole, amoxicillin, Cepastat Lozenges (phenol) clarithromycin) Dequadin Lozenges (dequalinium) Losec 1-2-3-M (omeprazole, clarithromycin, Fisherman’s Friend (menthol) metronidazole) Halls (eucalyptus oil, menthol) Nexium (esomeprazole) Strepsils (hexylresorcinol) Novo-Famotidine (famotidine) Sucrets (dyclonine) Novo-Misoprostol Nu-Cimet (cimetidine) Nu-Ranit (ranitidine) MANIA THERAPY Panto IV (pantoprazole) LITHIUM SALTS Pantoloc (pantoprazole) Carbolith Pariet (rabeprazole) Duralith Pepcid AC (famotidine) Lithane Pepcid, IV (famotidine) Lithium Prevacid (lansoprazole) Pylorid (ranitidine) MUSCLE RELAXANT Tagamet (cimetidine) 282 MEP (ASA, meprobamate) Ulcidine (famotidine) Acetazone Forte (acetaminophen, 13
Substance Classification Booklet – 2004 Permitted Substances chlorzoxazone) Tylenol Menstrual (acetaminophen, Acetazone C8 (acetaminophen, pamabrom, pyrilamine) √ chlorzoxazone, codeine) Apo-Baclofen Apo-Cyclobenzaprine SEDATIVES Apo-Alpraz (alprazolam) Aspirin Backache (ASA, methocarbamol) Apo-Bromazepam Dantrium Capsules (dantrolene) Nembutal (pentobarbital) Flexeril (cyclobenzaprine) Novo-Alprazol (alprazolam) Glycopyrrolate Nu-Alpraz (alprazolam) Lioresal (baclofen) Nu-Loraz (lorazepam) Liotec (baclofen) Nytol plain, Extra Strength Methoxacet (methocarbamol, (diphenhydramine) acetaminophen) PMS-Chloral Hydrate Methoxacet-C (methocarbamol, Serax (oxazepam) acetaminophen, codeine) Starnoc (zaleplon) Methoxisal (methocarbamol, ASA) Tranxene (clorazepate) Methoxisal-C (methocarbamol, ASA, Unisom Extra Strength/Extra Strength codeine) Sleepgels (diphenhydramine) Norflex (orphenadrine) Valium Roche Oral (diazepam) Norgesic, -Forte (orphenadrine, ASA) Novo-cycloprine (cyclobenzaprine) Nu-Baclo (baclofen) SMOKING CESSATION AIDS Parafon Forte (acetaminophen and Habitrol (nicotine) chlorzoxazone) Nicoderm (nicotine) Ratio-Baclofen Nicorette, -Plus (nicotine) Ratio-Cyclobenzaprine Nicotrol (nicotine) Robaxacet, -Extra Strength (methocarbamol, Zyban (bupropion) acetaminophen) Robaxin, -750 (methocarbamol) VAGINAL Robaxisal, -Extra Strength (methocarbamol, AVC (sulphanilamide) ASA) Betadine (povidone iodine) Robaxisal-C (methocarbamol, ASA, codeine) Canesten Vaginal (clotrimazole) Soma (carisoprodol) Clotrimaderm (clotrimazole) Tylenol Aches and Strains (acetaminophen, Dolacin Vaginal Cream (clindamycin) chlorzoxazone) Flagyl (metronidazole) Flagystatin (metronidazole, nystatin) PREMENSTRUAL SYNDROME AND Gynecure (tioconazole) DYSMENORRHEA Micozole (miconazole) Midol Regular, -Traditional (ASA, caffeine) Monazole-7 (miconazole) Midol Extra Strength (acetaminophen, Monistat (miconazole) caffeine, pyrilamine) Mycostatin (nystatin) Midol PMS Extra Strength (acetaminophen, Nidagel (metronidazole) pamabrom, pyrilamine) Nilstat (nystatin) Pamprin, -Extra Strength, -PMS Nyaderm (nystatin) (acetaminophen, pyrilamine, pamabrom) Terazol (terconazole) 14
Substance Classification Booklet – 2004 Permitted Substances Other Various Medications Amatine (midodrine) Duofilm (salicylic acid) Eltroxin (levothyroxine) √ Enbrel (etanercept) Imuran (azathioprine) Synthroid (levothyroxine) 15
Substance Classification Booklet – 2004 2004 WADA Prohibited List The 2004 WADA Prohibited List The World Anti-Doping Agency (WADA) seeks to foster a doping-free culture in sport. It combines the resources of sport and government to enhance, supplement and coordinate existing efforts to educate athletes about the harms of doping, reinforce the ideal of fair play and sanction those who cheat themselves and their sport. WADA created the World Anti-Doping Program which encompasses all the elements needed in order to ensure optimal harmonization and best practice in international and national anti-doping programs. It includes three main elements: The World Anti-Doping Code, International Standards and Models of Best Practices. The purposes of the World Anti-Doping Program and the World Anti-Doping Code are: – To protect athletes’ fundamental right to participate in doping-free sport and thus x promote health, fairness and equality for athletes worldwide; and – To ensure harmonized, coordinated and effective anti-doping programs at the international and national level with regard to detection, deterrence and prevention of doping. International Standards are developed for different technical and operational areas within an anti-doping program and their purpose is harmonization among Anti-Doping Organizations (ADO), such as the CCES and international sport federations, responsible for specific technical and operational parts of anti-doping programs. The International Standard for the Prohibited List was developed by the WADA List and Health, Medical and Research Committees based on extensive input from Signatories (entities signing the Code and agreeing to comply with the Code) and governments. The principal purpose of the WADA Prohibited List is to establish under the rules of the World Anti-Doping Code the substances and methods which are prohibited in sport. The Code (4.3) states: “4.3 WADA shall consider the following criteria in deciding whether to include a substance or method on the Prohibited List. 4.3.1. A substance or method shall be considered for inclusion on the Prohibited List if WADA determines that the substance or method meets any two of the following three criteria: 4.3.1.1. Medical or other scientific evidence, pharmacological effect or experience that the substance or method has the potential to enhance or enhances sport performance; 4.3.1.2. Medical or other scientific evidence, pharmacological effect or experience that the use of the substance or method represents an actual or potential health risk to the athlete; 4.3.1.3. WADA's determination that the use of the substance or method violates the spirit of sport described in the Introduction of the Code 17
Substance Classification Booklet – 2004 2004 WADA Prohibited List 4.3.2. A substance or method shall also be included on the Prohibited List if WADA determines there is medical or other scientific evidence, pharmacological effect or experience that the substance or method has the potential to mask the use of other Prohibited Substances and Prohibited Methods. 4.3.3. WADA's determination of the Prohibited Substances and Prohibited Methods that will be included on the Prohibited List shall be final and shall not be subject to challenge by an athlete or other person based on an argument that the substance or method was not a masking agent or did not have the potential to enhance performance, represent a health risk, or violate the spirit of sport.” x The following is extracted from the 2004 WADA Prohibited List. It is divided in the following sections: – Substances (S) and Methods (M) Prohibited In-Competition – Substances Prohibited in Particular Sports – Substances (S) and Methods (M) Prohibited In- and Out- of Competition – Specified Substances – The 2004 Monitoring Program. For specific examples of Prohibited Substances, refer to the Prohibited Substances section. Although most national sport governing bodies and international sport federations prohibit the use of substances and methods outlined by WADA, it is important to note that some of the Prohibited Substances may vary from sport to sport. It is the athlete’s responsibility to know his or her sport’s anti-doping regulations. In cases of uncertainty, it is recommended to check with the appropriate relevant governing body and/or international sports federations. Substances (S) and Methods (M) Prohibited In-Competition S1. Stimulants Stimulants, identified by “S1.”, including their optical (D- and L-) isomers and other substances with similar chemical structure or similar pharmacological effects are prohibited. S2. Narcotics Narcotics, identified by “S2.”, are prohibited. S3. Cannabinoids Cannabinoids (eg. marijuana, hashish) are prohibited. S4. Anabolic agents All anabolic agents are prohibited. 18
Substance Classification Booklet – 2004 2004 WADA Prohibited List 1. Anabolic Androgenic Steroids (AAS) a. Exogenous1 Anabolic Androgenic Steroids Exogenous1 AAS and other substances with similar chemical structure or similar pharmacological effect(s), including but not limited to those identified by “S4.1a”, are prohibited. b. Endogenous2 Anabolic Androgenic Steroids Endogenous2 AAS and other substances with similar chemical structure or similar pharmacological effect(s), including but not limited to those identified by “S4.1b”, are prohibited. Where a Prohibited Substance is capable of being produced by the body naturally, a Sample will be deemed to contain such Prohibited Substance where the concentration of x the Prohibited Substance or its metabolites or markers and/or any other relevant ratio(s) in the Athlete’s Sample so deviates from the range of values normally found in humans so as not to be consistent with normal endogenous production. A Sample shall not be deemed to contain a Prohibited Substance in any such case where the Athlete proves by evidence that the concentration of the Prohibited Substance or its metabolites or markers and/or the relevant ratio(s) in the Athlete’s Sample is attributable to a pathological or physiological condition. In all cases, and at any concentration, the laboratory will report an adverse finding if, based on any reliable analytical method, it can show that the Prohibited Substance is of exogenous origin. If the laboratory result is not conclusive and no concentration as referred to in the above paragraph is found, the CCES shall conduct a further investigation if there are serious indications, such as a comparison to reference steroid profiles, for a possible Use of a Prohibited Substance. If the laboratory has reported the presence of a T/E ratio greater than six (6) to one (1) in the urine, further investigation is obligatory in order to determine whether the ratio is due to a physiological or pathological condition. In both cases, the investigation will include a review of any previous tests, subsequent tests and/or results of endocrine investigations. If previous tests are not available, the Athlete shall undergo an endocrine investigation or be tested unannounced at least three times within a three month period. Failure of the Athlete to co-operate in the investigations will result in considering the Athlete’s Sample to contain a Prohibited Substance. 2. Other Anabolic Agents Other anabolic agents, identified by “S4.2”, are prohibited. 1 Exogenous refers to a substance which is not capable of being produced by the body naturally. 2 Endogenous refers to a substance which is capable of being produced by the body naturally. 19
Substance Classification Booklet – 2004 2004 WADA Prohibited List S5. Peptide hormones The following substances including other substances with similar chemical structure or similar pharmacological effect(s) and their releasing factors are prohibited. 1. Erythropoietin (or EPO) (identified by “S5.1” ) 2. Growth hormone (hGH) and Insulin-like Growth Factor (IGF-1) (identified by “S5.2”) 3. Chorionic Gonadotrophin (hCG) prohibited in males only (identified by “S5.3”) 4. Pituitary and synthetic gonadotrophins (LH) prohibited in males only (identified by “S5.4”) x 5. Insulin (identified by “S5.5) 6. Corticotrophins (identified by “S5.6”) Unless the Athlete can demonstrate that the concentration was due to a physiological or pathological condition, a Sample will be deemed to contain a Prohibited Substance where the concentration of the Prohibited Substance or its metabolites and/or relevant ratios or markers in the Athlete’s Sample so exceeds the range of values normally found in humans so as not to be consistent with normal endogenous production. The presence of other substances with similar chemical structure or similar pharmacological effect(s), diagnostic marker(s) or releasing factors of a hormone listed above or of any other finding which indicate(s) that the substance detected is not the naturally present hormone, will be reported as an adverse analytical finding. S6. Beta-2 Agonists All Beta-2 agonists, including but not limited to those identified by “S6.”, including their D- and L- isomers are prohibited with the exception of formoterol, salbutamol, salmeterol and terbutaline which are permitted by inhalation only for the prevention and/or treatment of asthma and respiratory ailments with prior Abbreviated Therapeutic Use Exemption (TUE). Despite the granting of a TUE, concentrations of salbutamol in urine greater than 1000 ng/ml will be regarded as an adverse analytical finding unless the athlete proves that the abnormal result was the consequence of the therapeutic use of inhaled salbutamol. S7. Agents with anti-oestrogenic activity Agents with anti-oestrogenic activity, identified by “S7.”, are prohibited in males only. S8. Masking Agents Masking agents, including but not limited to those identified by “S8.”, are prohibited due to their potential to impair the excretion of Prohibited Substances, to conceal their presence in urine or other samples used in doping control, or to change haematological parameters. A TUE is not valid if an athlete’s urine contains a diuretic, including but not limited to 20
Substance Classification Booklet – 2004 2004 WADA Prohibited List those identified by “S8/P3.” and other substances with similar chemical structure or similar pharmacological effects, in association with threshold or sub-threshold levels of a Prohibited Substance(s). S9. Glucocorticosteroids Glucocorticosteroids, including but not limited to those identified by “S9.”, are prohibited when administered orally, rectally, or by intravenous or intramuscular administration. All other administration routes require prior Abbreviated TUE. x Table 1: Glucocorticosteroid routes of administration and their status in sport Route of Prohibited Permitted with prior Permitted Administration Abbreviated TUE (✍) oral (ex. pill form) • rectal (ex. suppository) • intravenous injection • intramuscular injection • local injection • intra-articular injection • inhalation (ex. pump) • topical (ex. cream, • lotion, ointment) anal (ie. around the anus) • aural (ex. ear drop) • nasal (ex. nasal spray) • ophthalmic (ex. eye drops) • M1. Enhancement of oxygen transfer a. Blood doping. Blood doping is the use of autologous, homologous or heterologous blood or red blood cell products of any origin, other than for legitimate medical treatment. b. The use of products that enhance the uptake, transport or delivery of oxygen, e.g. erythropoietins, modified haemoglobin products including but not limited to haemoglobin-based blood substitutes, microencapsulated haemoglobin products, perfluorochemicals, and efaproxiral (RSR13). M2. Pharmacological, chemical, and physical manipulation Pharmacological, chemical and physical manipulation is the use of substances and methods, including masking agents, which alter, attempt to alter or may reasonably be expected to alter the integrity and validity of specimens collected in doping controls. These include but are not limited to catheterization, urine substitution and/or tampering, 21
Substance Classification Booklet – 2004 2004 WADA Prohibited List inhibition of renal excretion and alterations of testosterone and epitestosterone concentrations. M3. Gene doping Gene or cell doping is defined as the non-therapeutic use of genes, genetic elements and/or cells that have the capacity to enhance athletic performance. Substances Prohibited in Particular Sports x P1. Alcohol Unless otherwise specified, alcohol (ethanol), identified by “P1.” is prohibited in competition only in the following sports. Detection will be conducted by breath analysis and/or blood. The doping violation threshold for each sport federation is reported in parenthesis (if no threshold is indicated, the presence of any quantity of alcohol shall constitute a doping violation). • Aeronautic (FAI) (0.05 g/L) • Archery (FITA) (0.10 g/L) • Automobile (FIA) • Billiards (WCBS) • Boules (CMSB) (0.50 g/L) • Gymnastics (FIG) (0.10 g/L) • Karate (WKF) (0.40 g/L) • Modern Pentathlon (UIPM) (0.10 g/L) • Motorcycling (FIM) • Roller Sports (FIRS) (0.02 g/L) • Skiing (FIS) • Triathlon (ITU) (0.40 g/L) • Wrestling (FILA) P2. Beta-Blockers Unless otherwise specified, beta-blockers, including but not limited to those identified by “P2.”, are prohibited in competition only in the following sports: • Aeronautic (FAI) • Archery (FITA) (also prohibited out of competition) • Automobile (FIA) • Billiards (WCBS) • Bobsleigh (FIBT) • Boules (CMSB) • Bridge (FMB) • Chess (FIDE) • Curling (WCF) • Gymnastics (FIG) 22
Substance Classification Booklet – 2004 2004 WADA Prohibited List • Modern Pentathlon (UIPM) • Motorcycling (FIM) • Nine-pin Bowling (FIQ) • Sailing (ISAF) (match race helms only) • Shooting (ISSF) (also prohibited out of competition) • Skiing (FIS) (in ski jumping and free style snow board) • Swimming (FINA) (in diving and synchronised swimming) • Wrestling (FILA) P3. Diuretics x Diuretics, including but not limited to those identified by “P3”, are prohibited in all sports as masking agents. However, in the following weight-classified sports and sports where weight loss can enhance performance, no Therapeutic Use Exemptions shall be granted for use of diuretics. • Body-Building (IFBB) • Boxing (AIBA) • Judo (IJF) • Karate (WKF) • Powerlifting (IPF) • Rowing (light weight) (FISA) • Skiing (FIS) for ski jumping only • Taekwondo (WTF) • Weightlifting (IWF) • Wrestling (FILA) • Wushu (IWUF) Substances (S) and Methods (M) Prohibited In and Out of Competition S4. Anabolic Agents S5. Peptide Hormones S6. Beta-2 Agonists (only clenbuterol and salbutamol when its concentration is greater than 1000ng/mL) S7. Agents with Anti-Oestrogenic Activity S8. Masking Agents M1. Enhancement of Oxygen Transfer M2. Pharmacological, Chemical, and Physical Manipulation M3. Gene Doping P2. Beta Blockers in Archery and Shooting 23
Substance Classification Booklet – 2004 2004 WADA Prohibited List Specified Substances An anti-doping violation involving the following substances may result in a reduced sanction provided that the athlete can establish that the use of such specified substance was not intended to enhance sport performance. • Stimulants: ephedrine, L-methylamphetamine, methylephedrine • Cannabinoids • Inhaled beta-2 Agonists (except clenbuterol) • Diuretics (this does not apply to section P3) • Glucocorticosteroids x • Masking agents: Probenecid • Beta Blockers • Alcohol The 2004 Monitoring Program The WADA Code (4.5) states “WADA, in consultation with other Signatories and governments, shall establish a monitoring program regarding substances which are not on the Prohibited List, but which WADA wishes to monitor in order to detect patterns of misuse in sport.” The following substances are placed on the 2004 Monitoring List: Stimulants: In-Competition Only: caffeine, phenylephrine, phenylpropanolamine, pipradrol, pseudoephedrine, synephrine. Narcotics: In-Competition Only: morphine/codeine ratio. 24
Substance Classification Booklet – 2004 Prohibited Substances Prohibited Substances The following is a non-exhaustive list in alphabetical order of Prohibited Substances. It includes substances that are prohibited in particular sports only and those that require an Abbreviated Therapeutic Use Exemption (refer to the Therapeutic Use Exemption (TUE) section of this Booklet). Please note that this non-exhaustive list does not contain any examples of Prohibited Methods. Generic medicines are often named by the abbreviation of the company followed by the chemical name of the substance eg: Apo-, Depo-, Gen-, Lin-, Neo-, Novo-, PMS-, Ratio-, Rho-, Rhoxal, Riva-, Solu-, and Taro-. For example, Apo-Salbutamol is salbutamol. The first letter and number (eg. S3) indicate the class of Prohibited Substances in which x the product falls into (categorized in the 2004 WADA Prohibited List section of this Booklet ). Generic names or non-proprietary names are written in plain text and brand names are in bold. For each brand name the Prohibited Substance is indicated in brackets. Legend: ✍ - may be permitted with prior Abbreviated TUE - is prohibited in males only † - foreign product 25
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