STEMI ASSOCIATED WITH SARS-COV-2 INFECTION AND THE USE OF ECMO AS A POTENTIAL THERAPEUTIC APPROACH IN ADDITION TO THE PCI - OXFORD ACADEMIC JOURNALS

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STEMI ASSOCIATED WITH SARS-COV-2 INFECTION AND THE USE OF ECMO AS A POTENTIAL THERAPEUTIC APPROACH IN ADDITION TO THE PCI - OXFORD ACADEMIC JOURNALS
Oxford Medical Case Reports, 2021;3,82–85

                                                                                doi: 10.1093/omcr/omaa148
                                                                                Case Report

CASE REPORT

STEMI associated with SARS-CoV-2 infection and the

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use of ECMO as a potential therapeutic approach in
addition to the PCI
Tanvir Rahman∗,† , Quazim A. Alayo, Sibgha G. Chaudhary,
Reihaneh C. Moghadam, Matthew L. German, Neil A. Ettinger,
Jeremy E. Leidenfrost, Hope A. Cranston-D’amato, Morton R. Rinder and
Julianne E. Donnelly
St. Luke’s Hospital, Chesterfield, MO, USA
∗ Correspondence   address. St. Luke’s Hospital, Chesterfield, MO 63017, USA. Tel: +1 636-253-1232; E-mail: tanvir.rahman@stlukes-stl.com

Abstract
A 55-year-old male presented to the emergency department with the complaints of chest pain that started 4 h before
presentation. Pain was located over the anterior chest, 5 out of 10 intensity, with radiation to the left arm. Chest x-ray on
admission showed severe diffuse bilateral pulmonary infiltrates concerning for COVID-19 pneumonia. Electrocardiogram
showed inferior and lateral ST-segment elevation compatible with acute inferolateral myocardial infarction. Successful
percutaneous coronary intervention (PCI) of the proximal and mid-right coronary artery using the balloon angioplasty and
drug-eluting stent was performed. Post-PCI stenosis was 0% with a thrombolysis in myocardial infarction (TIMI) f low of 3.
Five-day course of azithromycin and hydroxychloroquine was completed with no improvement overall. Patient received two
doses of 400 mg of tocilizumab intravenously on hospital days 5 (HD#5) and #6. The patient was proned, on FiO2 100%, PEEP
15 cm H2 O, on epoprostenol sodium and paralytics and eventually received venovenous ECMO, which improved outcome.

INTRODUCTION                                                                    chest pain that started 4 h before presentation. Pain was 5
                                                                                out of 10 in intensity, with radiation to the left arm, and no
Thrombosis with severe acute respiratory syndrome coronavirus
                                                                                associated shortness of breath (SOB). He also reported a 2-week
infection has been reported in the past [1], which is believed to be
                                                                                history of dry cough and fever. Patient is a police officer, and two
caused from exaggerated cytokine response from the viral infec-
                                                                                of his coworkers tested positive for SARS-CoV-2 infection. Past
tion. Here, we present a case with severe acute respiratory syn-
                                                                                medical history significant for hypertension, hyperlipidemia,
drome coronavirus −2 (SARS-CoV-2) infection presenting with
                                                                                coronary artery disease (CAD) status post-percutaneous coro-
right coronary artery (RCA) thrombosis.
                                                                                nary intervention (PCI) with drug-eluting stent (DES) in 2005
                                                                                and coronary artery bypass graft × 4 in 2008, untreated type
CASE REPORT                                                                     II diabetes mellitus and polycythemia. Differential diagnosis
A 55-year-old male presented to the emergency department in                     included acute coronary syndrome, acute pulmonary embolism,
April 2020, with the complaints of sudden-onset, left-anterior                  pneumonia due to corona virus disease-2019 (COVID-19), acute

† Tanvir
       Rahman, http://orcid.org/0000-0002-1106-3619
Received: September 4, 2020; Revised: November 11, 2020; Accepted: December 12, 2020
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STEMI ASSOCIATED WITH SARS-COV-2 INFECTION AND THE USE OF ECMO AS A POTENTIAL THERAPEUTIC APPROACH IN ADDITION TO THE PCI - OXFORD ACADEMIC JOURNALS
STEMI associated with SARS-CoV-2 infection      83

                                                                                    11:40 h. STEMI protocol was activated and patient was taken to
                                                                                    the cardiac catheterization lab. Left heart catheterization with
                                                                                    coronary angiography and graft injection showed 90% stenosis
                                                                                    of both proximal and mid-portion of the RCA with a TIMI flow
                                                                                    of 3. Saphenous vein grafts to mid-diagonal artery and mid-
                                                                                    obtuse marginal artery were patent. Left ventricular ejection
                                                                                    fraction was 55%. Successful PCI of the proximal and mid-RCA
                                                                                    using the balloon angioplasty and DES was performed. Post-PCI
                                                                                    stenosis was 0% with TIMI flow of 3 (Fig. 3). Severe hypoxia out of
                                                                                    proportion to the CAD was noted during the procedure. ECG post-
                                                                                    PCI showed near normalization of the ST-segment elevation
                                                                                    (Fig. 4). He was given prasugrel and started on eptifibatide drip

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                                                                                    and was transferred to the medical intensive care unit. Even
                                                                                    though his chest pain improved following the PCI, he was still
                                                                                    complaining of SOB requiring up to 10 L of oxygen by high-
                                                                                    flow nasal cannula (HFNC). Because of the rapid and abrupt
                                                                                    decompensation, he was intubated on the hospital day 1 (HD#1).
                                                                                    Five-day course of azithromycin and hydroxychloroquine was
                                                                                    completed with no significant improvement. Patient received
Figure 1: CXR on admission showing diffuse bilateral infiltrates involving almost   two doses of intravenous tocilizumab on HD#5 and #6. Refractory
all of the lung fields.                                                             hypoxemia (arterial blood gases: pH 7.41, pCO2 53.4, pO2 72.4,
                                                                                    HCO3 34) persisted despite maximal ventilator settings (proned,
on chronic heart failure exacerbation, myocarditis, pericarditis,                   FiO2 100%, PEEP 15 cm H2 O, epoprostenol sodium and paralytics).
tension pneumothorax and costochondritis.                                           Therefore, given his young age and otherwise healthy status, it
    Chest X-ray (CXR) on admission showed severe diffuse bilat-                     was decided to place him on venovenous (VV) ECMO support.
eral pulmonary infiltrates with air bronchograms (Fig. 1), which                    He was cannulated at the bedside with 25 French inferior vena
was concerning for COVID-19 pneumonia. Electrocardiogram                            cava cannula and 25 French right internal jugular cannula. Flow
(ECG) showed acute inferolateral ST-segment elevation myocar-                       of 6 L/minute was provided with FiO2 of 100% and sweep of 8.
dial infarction (STEMI). ST-segment depression in V1 and V2                         Ventilator mode was set to pressure-regulated volume control,
suggested posterior myocardial injury (Fig. 2). Initial cardiac tro-                very low tidal volume at 300 mL, 15 breaths/min, minute volume
ponin I (TnI) was 0.02 ng/L (reference range < 19 ng/L) at 7 h.                     4.5 L/min, PEEP 12 cm H2 O, FiO2 60%. On HD#9, interleukin 6
Reverse transcription–polymerase chain reaction was positive                        (IL-6) level was 86.9 pg/ml (a 12-fold decrease), and ECMO was
for SARS-CoV-2.                                                                     decannulated on the HD#13. He was extubated on the HD#16
    On physical examination, he was diaphoretic, heart rate 100                     and was breathing on 10 L oxygen by HFNC. He remained only
beats/minute (bpm), elevated blood pressure at 148/100 mm hg                        on dexmedetomidine, was awake and followed commands. On
and hypoxic on room air. Repeat TnI was elevated at 19 ng/L at                      HD#17, oxygen weaned to 4 L, and on HD#18, he was off of oxygen

Figure 2: ECG on admission showing marked ST-segment elevation (lead II, III, aVF and V4–V6).
STEMI ASSOCIATED WITH SARS-COV-2 INFECTION AND THE USE OF ECMO AS A POTENTIAL THERAPEUTIC APPROACH IN ADDITION TO THE PCI - OXFORD ACADEMIC JOURNALS
84      T. Rahman et al.

Figure 3: (A) LHC showing 90% stenosis in the proximal and mid-RCA. (B) Guidewire insertion in the RCA. (C) Deployment of the DES in the RCA. (D) Restored perfusion

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with 0% stenosis in the RCA after DES deployment.

Figure 4: Normalization of the ST-segment after LHC and PCI.

Table 1: Inflammatory markers pre- and post-tocilizumab and ECMO

Inflammatory markers and            Before anti-IL-6       After receiving
cytokine                            and ECMO               anti-IL-6 and
                                                           ECMO

IL-6 (reference range (RR):         1054.5                 86.9
0.0–15.5 PG/ml)
Crp (RR: 0.0–0.9 mg/dl)             42.8                   16
D-dimer (RR:
STEMI ASSOCIATED WITH SARS-COV-2 INFECTION AND THE USE OF ECMO AS A POTENTIAL THERAPEUTIC APPROACH IN ADDITION TO THE PCI - OXFORD ACADEMIC JOURNALS
STEMI associated with SARS-CoV-2 infection      85

DISCUSSION                                                            ETHICAL APPROVAL
SARS-CoV-2 uses angiotensin-converting enzyme-2 receptor as           No ethical approval was needed for this case report.
a portal of entry into target cells, including endothelium and
cardiac myocytes making heart tissue a common target for
the SARS-CoV-2 [2]. Several observational studies have reported
                                                                      CONSENT
cardiovascular complications of SARS-CoV-2 infection, including
myocardial injury and myocarditis, acute coronary syndrome,           Used for educational purpose with full confidentiality of
acute heart failure, cardiomyopathies, elevated troponins,            patient information. Patient’s written consent was obtained and
cardiac dysrhythmias and venous thromboembolic events                 submitted.
[3, 4]. Little is known about the pathophysiology of acute
coronary syndrome (ACS) in SARS-CoV-2 infection. Multiple
mechanisms have been postulated including direct myocardial
                                                                      GUARANTOR

                                                                                                                                           Downloaded from https://academic.oup.com/omcr/article/2021/3/omaa148/6161395 by guest on 30 November 2021
injury, plaque rupture due to severe acute inflammation,
aggravation of preexisting CAD, altered myocardial demand–            Julianne E. Donnelly, MD.
supply ratio, coronary thrombosis. It is plausible that, the COVID-
19 infection facilitated the thrombosis in the RCA by inducing
a hypercoagulable state [5] in a patient already prone to ACS
from preexisting CAD and polycythemia (admission hemoglobin           REFERENCES
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of Internal Medicine, Department of Cardiology, Department of             Eritsland J, et al. IL-6 signalling in patients with acute ST-
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Pulmonary and Critical Care Medicine, Department of Cardio-               10.1016/j.rinim.2013.11.002.
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J. Balis, Program Director, St Luke’s Hospital Internal Medicine          support in severe COVID-19. Ann Thorac Surg 2020. doi:
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CONFLICT OF INTEREST
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                                                                          AS, Fan E, et al. Extracorporeal membrane oxygenation sup-
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