STEMI ASSOCIATED WITH SARS-COV-2 INFECTION AND THE USE OF ECMO AS A POTENTIAL THERAPEUTIC APPROACH IN ADDITION TO THE PCI - OXFORD ACADEMIC JOURNALS
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Oxford Medical Case Reports, 2021;3,82–85 doi: 10.1093/omcr/omaa148 Case Report CASE REPORT STEMI associated with SARS-CoV-2 infection and the Downloaded from https://academic.oup.com/omcr/article/2021/3/omaa148/6161395 by guest on 30 November 2021 use of ECMO as a potential therapeutic approach in addition to the PCI Tanvir Rahman∗,† , Quazim A. Alayo, Sibgha G. Chaudhary, Reihaneh C. Moghadam, Matthew L. German, Neil A. Ettinger, Jeremy E. Leidenfrost, Hope A. Cranston-D’amato, Morton R. Rinder and Julianne E. Donnelly St. Luke’s Hospital, Chesterfield, MO, USA ∗ Correspondence address. St. Luke’s Hospital, Chesterfield, MO 63017, USA. Tel: +1 636-253-1232; E-mail: tanvir.rahman@stlukes-stl.com Abstract A 55-year-old male presented to the emergency department with the complaints of chest pain that started 4 h before presentation. Pain was located over the anterior chest, 5 out of 10 intensity, with radiation to the left arm. Chest x-ray on admission showed severe diffuse bilateral pulmonary infiltrates concerning for COVID-19 pneumonia. Electrocardiogram showed inferior and lateral ST-segment elevation compatible with acute inferolateral myocardial infarction. Successful percutaneous coronary intervention (PCI) of the proximal and mid-right coronary artery using the balloon angioplasty and drug-eluting stent was performed. Post-PCI stenosis was 0% with a thrombolysis in myocardial infarction (TIMI) f low of 3. Five-day course of azithromycin and hydroxychloroquine was completed with no improvement overall. Patient received two doses of 400 mg of tocilizumab intravenously on hospital days 5 (HD#5) and #6. The patient was proned, on FiO2 100%, PEEP 15 cm H2 O, on epoprostenol sodium and paralytics and eventually received venovenous ECMO, which improved outcome. INTRODUCTION chest pain that started 4 h before presentation. Pain was 5 out of 10 in intensity, with radiation to the left arm, and no Thrombosis with severe acute respiratory syndrome coronavirus associated shortness of breath (SOB). He also reported a 2-week infection has been reported in the past [1], which is believed to be history of dry cough and fever. Patient is a police officer, and two caused from exaggerated cytokine response from the viral infec- of his coworkers tested positive for SARS-CoV-2 infection. Past tion. Here, we present a case with severe acute respiratory syn- medical history significant for hypertension, hyperlipidemia, drome coronavirus −2 (SARS-CoV-2) infection presenting with coronary artery disease (CAD) status post-percutaneous coro- right coronary artery (RCA) thrombosis. nary intervention (PCI) with drug-eluting stent (DES) in 2005 and coronary artery bypass graft × 4 in 2008, untreated type CASE REPORT II diabetes mellitus and polycythemia. Differential diagnosis A 55-year-old male presented to the emergency department in included acute coronary syndrome, acute pulmonary embolism, April 2020, with the complaints of sudden-onset, left-anterior pneumonia due to corona virus disease-2019 (COVID-19), acute † Tanvir Rahman, http://orcid.org/0000-0002-1106-3619 Received: September 4, 2020; Revised: November 11, 2020; Accepted: December 12, 2020 © The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com 82
STEMI associated with SARS-CoV-2 infection 83 11:40 h. STEMI protocol was activated and patient was taken to the cardiac catheterization lab. Left heart catheterization with coronary angiography and graft injection showed 90% stenosis of both proximal and mid-portion of the RCA with a TIMI flow of 3. Saphenous vein grafts to mid-diagonal artery and mid- obtuse marginal artery were patent. Left ventricular ejection fraction was 55%. Successful PCI of the proximal and mid-RCA using the balloon angioplasty and DES was performed. Post-PCI stenosis was 0% with TIMI flow of 3 (Fig. 3). Severe hypoxia out of proportion to the CAD was noted during the procedure. ECG post- PCI showed near normalization of the ST-segment elevation (Fig. 4). He was given prasugrel and started on eptifibatide drip Downloaded from https://academic.oup.com/omcr/article/2021/3/omaa148/6161395 by guest on 30 November 2021 and was transferred to the medical intensive care unit. Even though his chest pain improved following the PCI, he was still complaining of SOB requiring up to 10 L of oxygen by high- flow nasal cannula (HFNC). Because of the rapid and abrupt decompensation, he was intubated on the hospital day 1 (HD#1). Five-day course of azithromycin and hydroxychloroquine was completed with no significant improvement. Patient received Figure 1: CXR on admission showing diffuse bilateral infiltrates involving almost two doses of intravenous tocilizumab on HD#5 and #6. Refractory all of the lung fields. hypoxemia (arterial blood gases: pH 7.41, pCO2 53.4, pO2 72.4, HCO3 34) persisted despite maximal ventilator settings (proned, on chronic heart failure exacerbation, myocarditis, pericarditis, FiO2 100%, PEEP 15 cm H2 O, epoprostenol sodium and paralytics). tension pneumothorax and costochondritis. Therefore, given his young age and otherwise healthy status, it Chest X-ray (CXR) on admission showed severe diffuse bilat- was decided to place him on venovenous (VV) ECMO support. eral pulmonary infiltrates with air bronchograms (Fig. 1), which He was cannulated at the bedside with 25 French inferior vena was concerning for COVID-19 pneumonia. Electrocardiogram cava cannula and 25 French right internal jugular cannula. Flow (ECG) showed acute inferolateral ST-segment elevation myocar- of 6 L/minute was provided with FiO2 of 100% and sweep of 8. dial infarction (STEMI). ST-segment depression in V1 and V2 Ventilator mode was set to pressure-regulated volume control, suggested posterior myocardial injury (Fig. 2). Initial cardiac tro- very low tidal volume at 300 mL, 15 breaths/min, minute volume ponin I (TnI) was 0.02 ng/L (reference range < 19 ng/L) at 7 h. 4.5 L/min, PEEP 12 cm H2 O, FiO2 60%. On HD#9, interleukin 6 Reverse transcription–polymerase chain reaction was positive (IL-6) level was 86.9 pg/ml (a 12-fold decrease), and ECMO was for SARS-CoV-2. decannulated on the HD#13. He was extubated on the HD#16 On physical examination, he was diaphoretic, heart rate 100 and was breathing on 10 L oxygen by HFNC. He remained only beats/minute (bpm), elevated blood pressure at 148/100 mm hg on dexmedetomidine, was awake and followed commands. On and hypoxic on room air. Repeat TnI was elevated at 19 ng/L at HD#17, oxygen weaned to 4 L, and on HD#18, he was off of oxygen Figure 2: ECG on admission showing marked ST-segment elevation (lead II, III, aVF and V4–V6).
84 T. Rahman et al. Figure 3: (A) LHC showing 90% stenosis in the proximal and mid-RCA. (B) Guidewire insertion in the RCA. (C) Deployment of the DES in the RCA. (D) Restored perfusion Downloaded from https://academic.oup.com/omcr/article/2021/3/omaa148/6161395 by guest on 30 November 2021 with 0% stenosis in the RCA after DES deployment. Figure 4: Normalization of the ST-segment after LHC and PCI. Table 1: Inflammatory markers pre- and post-tocilizumab and ECMO Inflammatory markers and Before anti-IL-6 After receiving cytokine and ECMO anti-IL-6 and ECMO IL-6 (reference range (RR): 1054.5 86.9 0.0–15.5 PG/ml) Crp (RR: 0.0–0.9 mg/dl) 42.8 16 D-dimer (RR:
STEMI associated with SARS-CoV-2 infection 85 DISCUSSION ETHICAL APPROVAL SARS-CoV-2 uses angiotensin-converting enzyme-2 receptor as No ethical approval was needed for this case report. a portal of entry into target cells, including endothelium and cardiac myocytes making heart tissue a common target for the SARS-CoV-2 [2]. Several observational studies have reported CONSENT cardiovascular complications of SARS-CoV-2 infection, including myocardial injury and myocarditis, acute coronary syndrome, Used for educational purpose with full confidentiality of acute heart failure, cardiomyopathies, elevated troponins, patient information. Patient’s written consent was obtained and cardiac dysrhythmias and venous thromboembolic events submitted. [3, 4]. Little is known about the pathophysiology of acute coronary syndrome (ACS) in SARS-CoV-2 infection. Multiple mechanisms have been postulated including direct myocardial GUARANTOR Downloaded from https://academic.oup.com/omcr/article/2021/3/omaa148/6161395 by guest on 30 November 2021 injury, plaque rupture due to severe acute inflammation, aggravation of preexisting CAD, altered myocardial demand– Julianne E. Donnelly, MD. supply ratio, coronary thrombosis. It is plausible that, the COVID- 19 infection facilitated the thrombosis in the RCA by inducing a hypercoagulable state [5] in a patient already prone to ACS from preexisting CAD and polycythemia (admission hemoglobin REFERENCES 17.9 g/dl and hematocrit 51.1%). IL-6 plays a significant role 1. WL-m Y X-h, Ai-bin L, Zhu G. Severe acute respiratory syn- to cause ‘cytokine storm’ in acute inflammatory settings and drome and venous thromboembolism in multiple organs. reported to be associated with myocardial injury [6]. 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