RESEARCH SYMPOSIUM Friday, April 30 | Virtual Conference - Department of Medicine
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Department of Medicine RESE A RC H 2021 SY M P OS IU M Friday, April 30 | Virtual Conference
FROM THE VICE CHAIR FOR RESEARCH
From the Vice Chair for Research
We would like to thank all of the participants for sharing their
innovative research, as well as those who coordinated and attended
this event. Your support for our research mission is greatly
appreciated.
Many thanks to the judges who contributed their time and effort to
make the 14th Annual Department of Medicine Research Symposium
a successful event.
Ruth Adekunle, M.D. Diane Kamen, M.D., MSCR
Emily Brennan, MLIS Margaret Markiewicz, M.D.
Thomas Di Salvo, M.D., MBA Paul McDermott, Ph.D.
Gary Gilkeson, M.D. William Moran, M.D., MS
Hamza Hashmi, M.D. Zengdun Shi, M.D.
Joshua Lipschutz, M.D. Charlie Strange, M.D.
Sincerely,
Jim Oates, M.D.
Professor and Director
Division of Rheumatology & Immunology
Vice Chair for Research, Department of Medicine
Medical University of South Carolina
2 D E PA R T M E N T O F M E D I C I N E
SCHEDULE OF EVENTS
Schedule of Events
2021 VIRTUAL RESEARCH SYMPOSIUM
Friday, April 30 | Live Streaming: Microsoft Teams
8:00 am - 8:30 am Welcome and Opening Remarks
Jim Oates, M.D., Vice Chair for Research
8:30 am - 11:00 am Poster Presentations
11:30 am - 12:30 pm Oral Abstract Presentations
12:30 pm - 1:15 pm Keynote Presentation by Jeremy Reiter, M.D., Ph.D.
Professor & Chair, Department of Biochemistry and
Biophysics, University of California, San Francisco
1:15 pm - 1:45 pm Research Day Poster Award Ceremony
Awards recognizing the best research day presentations will be
given in the following categories:
• Oral Presenters
• Junior Faculty
• Postdoctoral Fellows
• Residents/Fellows
• Graduate Students
• Medical Students
2021 RESEARCH SYMPOSIUM 3
K E Y N OT E
Keynote: Jeremy Reiter, M.D., Ph.D.
“How Cilia Signal, and How I Got so Fascinated by
this Organelle”
Dr. Jeremy Reiter is a professor and chair of the Department of
Biochemistry and Biophysics at the University of California, San Francisco.
His lab investigates how cilia form, signal and function in intercellular
communication. Their achievements include:
• The discovery that Smoothened, a critical component of the
Hedgehog pathway, localizes to and works in cilia. This was the first
demonstration that the Hedgehog signal transduction machinery
functions at cilia.
• They were the first to show that cancers can be ciliated and that
cancers can require cilia for growth.
Jeremy Reiter, M.D., Ph.D. • They helped show that the region at the base of the cilium called the
Professor & Chair, Department transition zone is a gate that controls ciliary composition. For example,
of Biochemistry and Biophysics the transition zone regulates the ciliary localization of Smoothened
University of California, San
and, therefore, is required for Hedgehog signaling.
Francisco
• They identified many transition zone components and discovered that
some ciliopathies are caused by inherited human mutations in these
transition zone components.
• They found a phosphoinositide that marks the ciliary membrane
and helps direct which proteins localize to cilia. This was the first
identification of a specific cilia-enriched lipid.
• They investigated how cilia regulate adult tissue homeostasis. Recently,
they have shown how cilia of hypothalamic neurons signal to regulate
satiety and how cilia restrict adipogenesis.
Dr. Reiter graduated magna cum laude in biochemistry from Yale
College and completed his PhD and MD in the combined program at
UCSF. In 1993, as a young scientist at UCSF, he was an ARCS Scholar;
since then, he has mentored many young scientists, including other
ARCS Scholars. He has received multiple academic awards, including
the Presidential Early Career Award fro Scientists and Engineers, the
R.R. Bensley Award in Cell Biology and the ARCS Distinguished
Scholar Alumni Award. His current research focuses on how cilia sense
cues from other cells to pattern tissues during embryonic development.
4 D E PA R T M E N T O F M E D I C I N E
ORA L A BST RAC T PRES ENTER S
Oral Abstract Presenters
Krutika Kuppalli, M.D.
Assistant Professor, Division of Infectious Diseases
Category: Junior Faculty
Mentor: Cassandra Salgado, M.D., MS
Title: Epidemiology of COVID-19 Illness among Employees, Trainees, and Faculty
(ETF) of an Academic Health System (AHS)
Denisha Spires, Ph.D.
Postdoctoral Scholar, Division of Nephrology
Category: Postdoctoral Fellow
Mentor: Daria Ilatovskaya, Ph.D.
Title: The Role of Atrial Natriuretic Peptide in Glomerular Damage in Salt-
Sensitive Hypertension
Christina Mingora, M.D.
Fellow, Division of Pulmonary, Critical Care, Allergy & Sleep Medicine
Category: Resident/Fellow
Mentors: Patrick Flume, M.D., and Susan Dorman
Title: Time-to-detection as a pre-treatment predictor for culture conversion in
patients with non-tuberculous mycobacterial pulmonary disease
Nour Hijazi
Category: Graduate Student
Mentor: Don Rockey, M.D.
Title: The role of paxillin in hepatic stellate cell activation and fibrogenesis
Sarah Smith
4th Year Medical Student
Category: Medical Student
Mentor: Paula Ramos, Ph.D.
Title: Genome-wide DNA Methylation and Gene Expression Signatures in Classical
Monocytes from African Ancestry Patients with Systemic Sclerosis
2021 RESEARCH SYMPOSIUM 5
P O S T E R PA R T I C I PA N T S
Poster Participants
Junior Faculty Postdoctoral Fellow Resident/Fellow
Category Category Category
Ruth Adekunle, M.D. Halim Bou Daher, M.D. Nnamdi Azih, M.D.
Mentor: Jessica Lewis, M.D. Mentor: Don Rockey, M.D. Mentors: Brian Houston, M.D. and
Title: Clinical Outcomes of Solid Title: Development of a risk scoring Ryan Tedford, M.D.
Organ Transplant Recipients with system to predict in-hospital Title: Indirect Fick and
Severe Acute Respiratory Syndrome mortality in patients with cirrhosis Thermodilution Cardiac Output
Coronavirus 2 admitted with upper gastrointestinal Measurements Have Significant
bleeding Variance Compared to Direct Fick
Krutika Kuppalli, M.D. in LVAD Patients
Mentor: Cassandra Salgado, M.D., MS Kareem Marrache, M.D.
Title: Epidemiology of COVID-19 Mentor: Don Rockey, M.D. H. Jensie Burton, M.D.
Illness among Employees, Trainees, Title: The Relationship Between Mentor: Eric Meissner, M.D., Ph.D.
and Faculty (ETF) of an Academic the Severity of Portal Hypertensive Title: Barriers to Hepatitis C
Health System (AHS) Gastropathy and Portal Treatment: An Observational
Hypertension Retrospective Study
Meghan Thomas, M.D.
Mentors: William Moran, M.D., MS, Denisha Spires, Ph.D. Avery Chisholm, M.D.
Marc Heincelman, M.D., Ben Kalivas, Mentor: Daria Ilatovskaya, Ph.D. Mentor: Wing-Kin Syn, MBChB,
M.D., Patrick Mauldin, Ph.D., and Title: The Role of Atrial Natriuretic Ph.D.
Jingwen Zhang, MS Peptide in Glomerular Damage in Title: Utility of the FAST score in
Title: Understanding the Salt-Sensitive Hypertension identifying US Veterans with high
Association between Admission risk nonalcoholic steatohepatitis
Source and In-Hospital Delirium: Ashish Solanki, Ph.D. (NASH): a validation study
A Retrospective Cohort Study Mentor: Joshua Lipschutz, M.D.
Title: HGF induced activation William Dungan, M.D.
Xiaofeng Zuo, Ph.D. of Nephrin and Neph1, a novel Mentors: Puja Elias, M.D. and John
Mentor: Joshua Lipschutz, M.D. mechanism that participates in Romano, M.D.
Title: Role of the Exocyst, Primary podocytes recovery from injury Title: Tics In The Small Intestine,
Cilia, and Mitochondria in Acute An Unusual Case of Jejunal
Kidney Injury Diverticulitis
Travis Ferguson, M.D.
Mentor: Nicholas Pastis, M.D. and
Gerard Silvestri, M.D., MS
Title: Clinical Evaluation of the
Thin TCP-EBUS Bronchoscopy
System
6 D E PA R T M E N T O F M E D I C I N E *Poster Participants listed by category in alphabetical order.
P O S T E R PA R T I C I PA N T S
Poster Participants
Resident/Fellow Ahmadreza Karimianpour, D.O. Shaurya Prakash, M.D.
Category Mentor: Jeffrey Winterfield, M.D. Mentor: Don Rockey, M.D.
Title: Accessing the inaccessible: Title: Fibrosis Regression after Direct
epicardial mapping and ablation of Acting Antiviral Therapy in Patients
Adam Fox, M.D.
ventricular tachycardias from the with Chronic Hepatitis C Virus
Mentor: Gerard Silvestri, M.D., MS
coronary venous system in post- Infection and Cirrhosis
Title: Coordination of Biomarker
CABG patients.
Testing for Targeted Therapies in
Syed Quadri, M.D.
Non-Small Cell Lung Cancer
Monica Klaybor, M.D. Mentor: Ruth Campbell, M.D.
Mentor: Jennifer Bracey, MD Title: Reduction of intraoperative
Megan Goff, D.O.
Title: Off Target Effects of CFTR nephrotoxic antimicrobial exposure
Mentor: Blaithin McMahon,
Modulators on Serum Vitamin Levels can decrease the severity of stage
MB.BCh. BAO, Ph.D.
of Acute Kidney Injury and improve
Title: Continuous Renal Replacement
Jessica Lozier, M.D. renal recovery in patients undergoing
Therapy: a reversible cause of
Mentors: Gerard Silvestri, M.D., MS, heart transplantation
thrombocytopenia
and Stacey Fedewa, Ph.D.
Title: Demographic Differences in Jacob Read, M.D.
Zain Gowani, M.D.
Those Being Screened for Lung Mentors: Ryan Tedford, M.D. and
Mentor: Jeffrey Winterfield, M.D.
Cancer and Implications for Mass Brian Houston, M.D.
Title: Utility of Cardiac Computed
Screening in the U. Title: Hemodynamic Reserve
Tomography for Scar Assessment
Predicts Early Right Heart Failure
in Patients with Cardiac Sarcoidosis
Christina Mingora, M.D. After LVAD Implantation
Undergoing Catheter Ablation
Mentors: Patrick Flume, M.D. and
Susan Dorman, M.D. Harrison Smith, M.D.
Sarah Huse, D.O.
Title: Time-to-detection as a Mentor: Nichole Tanner, M.D.,
Mentors: Diane Kamen, M.D.,
pre-treatment predictor for MSCR
MSCR, Gary Gilkeson, M.D., and
culture conversion in patients with Title: Patient demographics and
Jim Oates, M.D.
non-tuberculous mycobacterial outcomes of a large national cohort
Title: Malignancy Risk in Patients with
pulmonary disease of patients undergoing lung cancer
Systemic Lupus Erythematosus
screening
Tejaswi Nadig, M.D.
Prarthana Jain, D.O.
Mentors: Patrick Flume, M.D. and Michelle Spiegel, M.D.
Mentor: Diane Kamen, M.D., MSCR
Bryan Garcia, M.D. Mentor: Andrew Goodwin, M.D.
Title: Factors that Impact Medication
Title: Factors associated with health- Title: Work Smarter, Not
Adherence in Hospitalized Patients
related quality of life in patients Harder: Innovative Re-Design of
with Lupus
with pulmonary nontuberculous Computerized Provider Order Entry
mycobacterium to Drive Evidence-Based Fluid
Carson Keck, M.D.
Prescribing
Mentors: Marc Heincelman, M.D.
and Andrew Schreiner, M.D.
Title: POCUS Curriculum for
Internal Medicine Residents: using
Sound Waves to Amplify the Exam 2021 RESEARCH SYMPOSIUM 7
P O S T E R PA R T I C I PA N T S
Poster Participants
Cameron Leyers
Resident/Fellow Graduate Student Mentor: Melissa Cunningham, M.D.
Category Category* Title: Altered ERα localization
differentially modulates immune cell
subsets
Molly Stone, M.D. Thelma Amoah
Mentor: Erin Forster, M.D., MPH Mentor: Daria Ilatovskaya, Ph.D.
Ryan Schibalski
Title: Adherence to Recommended Title: Effect of Atrial Natriuretic
Mentor: Daria Ilatovskaya, Ph.D.
Healthcare Maintenance Guidelines Peptide on Mitochondrial
Title: Sex differences in renal
by IBD Providers in a Tertiary Care Bioenergetics in Cortical Collecting
mitochondrial function of young
Center Duct Cells
healthy rats
Michael Sutton, D.O. Callie Clarke
Morgan Spicer
Mentor: Don Rockey, M.D. Mentor: Daria Ilatovskaya, Ph.D.
Mentor: Daria Ilatovskaya, Ph.D.
Title: Overuse of Intravenous Proton- Title: Differential Expression of
Title: The implications of salt-
Pump Inhibitors in the Treatment of Histaminergic System Components
deficiency in autosomal recessive
Low to Moderate Risk Peptic Ulcer in Renal Cortex during Salt-Sensitive
polycystic kidney disease
Bleeding Hypertension
*Participants were placed in the
Emily Vara, D.O. Mikhail Fomin, MS
category that most closely fit their
Mentor: Diane Kamen, M.D., MSCR, Mentor: Daria Ilatovskaya, Ph.D.
current title.
Dulaney Wilson, Ph.D., John Pearce, Title: Establishing the expression
Ph.D., and Jim Oates, M.D. of renal histamine receptors and
Title: Perfluoroalkyl Compound associated enzymes in the human
Serum Concentrations and kidney: a literature review
Community Vulnerability:
Medical Student
Associations with Lupus-Related Nour Hijazi Category
Autoantibodies and Disease Mentor: Don Rockey, M.D.
Title: The role of paxillin in
Wayne Bauerle
hepatic stellate cell activation and
Mentor: Heather Evans, M.D.
fibrogenesis
Title: Improving antibiotic
stewardship in acute appendicitis
Richa Jaiswal
through risk-based empiric treatment
Mentor: Don Rockey, M.D.
selection.
Title: Utility of the world
association of sarcoidosis and other
Noah Blaker
granulomatosis disease (wasog)
Mentors: Valerian Fernandes,
criteria for the diagnosis of hepatic
M.D., Katrina Bidwell, M.D., and
sarcoidosis
Christopher Nielsen, M.D
Title: Practical Differences Between
the Biradial and Femoral Approach
for Alcohol Septal Ablation
Nephritis
8 D E PA R T M E N T O F M E D I C I N E
P O S T E R PA R T I C I PA N T S
Poster Participants
Ian O'Connor Peyton Tharp
Medical Student Mentors: Don Rockey, M.D. and Mentors: Valerian Fernandes,
Category Anand Mehta, Ph.D. M.D., Katrina Bidwell, M.D., and
Title: NAFLD/NASH induces Christopher Nielsen, M.D
fucosylation and mannose N-linked Title: Immediate impact of alcohol
Daniel Cook glycan modifications septal ablation on left ventricular
Mentors: Valerian Fernandes, M.D. diastolic pressure in patients
and Christopher Nielsen, M.D. Julia Rodes with hypertrophic obstructive
Title: Long-Term Changes in Diastolic Mentors: Kelly Barh, D.O. and Taylor cardiomyopathy
Function in HOCM Patients Treated Crouch, Ph.D.
with Alcohol Septal Ablation Title: Gender Differences in Brian Troyer
Outcomes of Interdisciplinary Pain Mentor: Tamara Nowling, Ph.D.
Jonathan Hill Rehabilitation Title: Urine Biomarkers of Lupus
Mentor: Stephen Savage, M.D. Nephritis
Title: Pretreatment Prostate-Specific Dayvia Russell
Antigen Velocity Is Associated with Mentor: Jim Oates, M.D. Andrew Wortham
Biochemical Recurrence and Failure Title: Changes in Gene Expression Mentor: Don Rockey, M.D.
of Prostate Cancer in African- After Sepiapterin Treatment in Title: Prognosis and outcomes in
Americans and Low Risk Patients Lupus Nephritis Stimulated Human compensated and decompensated
Glomerular Endothelial Cells cirrhosis in correlation to hepatic
Morgan Hill venous pressure gradient
Mentor: Taufiek Konrad Rajab, M.D., Sarah Smith
and Steven Kubalak, Ph.D. Mentor: Paula Ramos, Ph.D. Brandon Xavier
Title: Partial Heart Transplantation: Title: Genome-wide DNA Mentor: Don Rockey, M.D.
a New Operation for Children Methylation and Gene Expression Title: Appropriateness of pre-
Requiring Valve Replacement Signatures in Classical Monocytes endoscopic evaluation in patients
from African Ancestry Patients with referred for iron deficiency anemia
Andraia Li Systemic Sclerosis
Mentors: John Kaczmar, M.D. and
Terry Day, M.D. Mary Kate Sullivan
Title: Safety of novel targeted Mentor: Don Rockey, M.D.
therapies and immunotherapy in Title: Normal or near normal
recurrent or metastatic head and neck aminotransferase levels in patients
squamous cell cancer: a meta-analysis with alcoholic cirrhosis
Veena Mehta Eric Taylor
Mentor: Vinayak Rohan, M.D. Mentors: Valerian Fernandes, M.D.
Title: Patients' Perspective Regarding and Katrina Bidwell, M.D.
Perceived Risk and Transplantation Title: Effect of the COVID-19
During the Early Period of Pandemic on Incidence of Patients
COVID-19 Pandemic: Results of a Presenting with STEMI at MUSC
Cross-Sectional Survey
*Poster Participants listed by category in alphabetical order. 2021 RESEARCH SYMPOSIUM 9
DEPARTMENT OF MEDICINE
As the largest Department in the MUSC College of Medicine, the Department of Medicine provides essential leadership to
numerous programs across the university, MUSC Health, and South Carolina.
Our Department—made up of ten divisions engaged in care at two hospital systems and multiple ambulatory practices—is
guided by our vision to provide superior patient care, to educate the next generation of physicians, and to perform seminal
discovery research. Our divisions are home to numerous NIH-funded, internationally renowned investigators, master clinicians,
and award-winning educators who are leaders in their specialized fields of medicine:
> Cardiology > Hospital Medicine
> Endocrinology, Diabetes & Metabolic Diseases > Infectious Diseases
> Gastroenterology & Hepatology > Nephrology
> General Internal Medicine > Pulmonary, Critical Care, Allergy & Sleep Medicine
> Hematology & Oncology > Rheumatology & Immunology
96 Jonathan Lucas Street | Suite 803, MSC 623 | Charleston, SC 29425
muschealth.org musc.edu/dom
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