Research Day May 8, 2021 - California Health Sciences University
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Research Day May 8, 2021
Welcome Attendees and Presenters,
On behalf of the CHSU Research Day Taskforce, we thank you for attending this virtual conference and hope you enjoy
learning about research projects in our local area, many of which from CHSU faculty and students.
We are excited about the newly developed CHSU Research Day program and have a lot to share with you! We have over
30 podium talks, and poster presentations for you to enjoy. In addition, there are more attendees joining us who will be
browsing throughout the day. We are honored to have Dr. Robert Kollmorgen, DO, Assistant Professor of Orthopaedic
Surgery, University of California San Francisco, deliver the keynote address: “Current concepts in the young adult and
athlete’s hip: Are we really preserving the hip?” After a short break, we will begin simultaneous podium and poster
presentations to maximize the benefits of Research Day, you are encouraged to visit the sessions that interest you,
challenge you and will stretch your knowledge! Finally, the event will conclude with a presentation by CHSU’s
Simulation Center Director, Leslie Catron M.A.ED, BSN, RN, CHSE titled “Interprofessional Education Using In-Situ
Simulation” and an awards presentation.
Virtual conferences are new to most of us, so we wanted to spend a bit of time explaining the process. If you need any
help with IT, Zoom, or how to present/organize in a virtual environment, please reach out to one of the taskforce
members listed below. We are here to help you and ensure you have a positive experience. The keynote and closing
presentations will occur in the main Zoom link and should be attended by all participants. After the break, virtual rooms
will be open for you to freely travel in and out of them. A room will be open for the Podium Presentation Series. Six
excellent presentations were hand-selected by the taskforce and include many exciting and broad topics. The podium
presentations occur at specific times (see agenda on next page). At the same time, there will be 30 breakout rooms open
for the poster presentations. You can enter and leave each of these breakout rooms at your convenience. The poster
presenters with odd numbers will be in their rooms from 10:30am to 11:15am, each room will be labeled with a number
and the presenter’s name. From 11:15am to 12:00pm, the even number poster presenters will be in their rooms to
guide you through their research topics. A complete list of all presenters and abstracts are included in this booklet for
your review. The podium presenters will also be in available in the poster breakout room for additional questions and
discussions.
The Zoom Link for the event will be included in the invite sent via email. We look forward to virtually meeting you and
appreciate your support in making our Research Day a success!
The CHSU Research Day Taskforce Members:
Edward Merino, PhD - emerino@chsu.edu
Chandra Kolli, MPharm, PhD - ckolli@chsu.edu
Karin Chao-Bushoven - kchaobushoven@chsu.edu
Jiehan Chen – jchen@chsu.edu
Katie Hoskins – khoskins@chsu.edu
Jessica McCune - jmccune@chsu.edu
2
CHSU Virtual Research Day
The California Health Sciences University (CHSU) Colleges of Osteopathic Medicine (COM) and Pharmacy (COP) are
pleased to invite you to their CHSU Virtual Research Day to be held on is Saturday, May 8, 2021. The CHSU Virtual
Research Day will showcase the research and scholarly activities by our students and faculty members. In addition, we
invite Resident Physicians/Pharmacists and their Faculty leading local Residency and Fellowship programs to participate.
As part of this event, we will host a competition for the best poster and podium presentation in various categories, such
as: Faculty, Resident Physician/Pharmacist, and Student. The top three presenters in each category will be recognized
with an award and a certificate at the event. CME credits will be offered for participation.
Date: Saturday, May 8, 2021
Time: 9:00 am – 1:00 pm
Zoom Meeting ID: 846 7018 8938
Passcode: 374401
Time Items Details
President - Florence T. Dunn
9:00 am – 9:15 am CHSU Leadership Welcome COM Dean - John Graneto, DO, MEd
COP Dean - Mark Okamoto, PharmD
Keynote Speaker
Robert Kollmorgen DO,
Current Concepts in the young adult and
9:15 am – 10: 15 am athlete’s hip: Are we really preserving the Assistant Professor of Orthopaedic Surgery,
hip? University of California San Francisco
10: 15 am – 10: 30 am Coffee Break
10:30 am – 10:45 am Podium #1 Vinayak Shenoy, PhD
10:45 am – 11:00 am Podium #2 Yasamin Mohammadi
11:00 am – 11:15 am Podium #3 Natalie S. Pardo
10:30 am – 11:15 am Odd Number Posters Odd Number Posters
11:15 am – 11:30 am Podium #4 Rahil N. Khasgiwale
11:30 am – 11:45 am Podium #5 Hany Ibrahim, MD
11:45 am – 12:00 pm Podium #6 Francis Dournayan
11:15 am – 12: 00 pm Even Number Posters Even Number Posters
Simulation and Health Education Leslie D. Catron, M.A.ED, BSN, RN, CHSE
12:00 pm – 1:00 pm
Training Simulation Center Director and Instructor
1:00 pm Awards and Recognition Edward Merino, PhD
3
Keynote Speaker
Our Keynote Speaker for Research Day is Dr. Robert Kollmorgen, DO, FAAOS,
FAOBOS, Assistant Professor of Orthopaedic Surgery at UCSF and Director of
Orthopaedic Surgery at UCSF Fresno. He will present on the topic of “Current
Concepts in the young adult and athlete’s hip: Are we really preserving the
hip?”
Dr. Kollmorgen is board certified in Orthopedic Surgery and fellowship-trained
in Hip Preservation. He is a member of the International Society of Hip
Arthroscopy and Preservation, the American Academy of Orthopaedic
Surgeons and the Arthroscopy Association of North America. He is an expert in
Hip arthroscopy and complete hip specialist. Treating such hip disorders as:
Femoral Acetabular Impingement Syndrome (FAI), hip dysplasia, abductor and
hamstring tears and arthritis. Specialty procedures include hip arthroscopy, Robert Kollmorgen D.O.,
Periacetabular Osteotomy, labral reconstruction and repair, abductor and FAAOS, FAOBOS
hamstring repair and Direct Anterior Total Hip Arthroplasty.
Assistant Professor of
He earned his medical degree from Ohio University College of Osteopathic Orthopaedic Surgery,
Medicine. His residency in Orthopedic Surgery was completed at Midwestern University of California
University, and he finished his fellowship in Hip Preservation at Duke San Francisco (UCSF)
University. and Director of Orthopaedic
Research, UCSF Fresno
Dr. Kollmorgen previously practiced as an orthopedic surgeon specializing in
sports medicine and instructed as an Associate Professor at Ohio University. He
also served as a Lieutenant Commander in the United States Navy.
He was awarded the Navy and Marine Corps Commendation Medal for
creating the hip preservation and hip arthroscopy program at Naval Hospital
Camp Pendleton. He also twice received Fellows award for Sports Medicine
Educator of the Year at Ohio University.
Dr. Kollmorgen is dedicated to providing compassionate and effective care. He
believes that excellent health begins with education and prevention and has
made it his mission to enlighten patients to ways they can take greater control
over their own health.
4
Closing Speaker
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5
Podium Presentations
Podium #1 Vinayak Shenoy, PhD
10:30-10:45 am Faculty
College of Pharmacy, California Health Sciences University
Title: Identification of SARS-CoV-2 Entry Inhibitors
Author(s): Vinayak Shenoy
Affiliation: College of Pharmacy
Abstract: There is an unmet medical need to identify therapies that can prevent SARS-CoV-2 infection
and improve the outcomes of COVID-19 patients. Intermolecular interactions between the virus spike
glycoprotein and Angiotensin converting enzyme 2 (ACE2) is responsible for the entry of SARS-CoV-2 into
the cells, particularly in the lung, heart, and intestine. Therapeutic molecules that can interfere with the
spike glycoprotein/ACE2 interaction can potentially prevent the viral entry of SARS-CoV-2.
To identify potential virus entry inhibitors, we screened various molecules using the ACE2 activity assay.
Our initial set of experiments revealed that the ACE2 activity was significantly decreased in the presence
of SARS-CoV-2 spike glycoprotein. Subsequent dose-response experiments using screening molecules
showed that the spike protein-induced decrease in ACE2 activity was completely reversed, suggesting
that the binding between the spike protein and the enzyme may be altered by these molecules.
Furthermore, immunoblotting studies in the Vero E6 cells derived from African green monkey kidney
revealed that pre-treatment with the screening molecules prevented the entry of SARS-CoV-2 spike
glycoprotein into the cells.
In conclusion, our experimental findings indicate a therapeutic potential of these molecules for COVID-19
treatment by acting as virus entry inhibitors. Further studies in human cells are warranted to measure
the effectiveness of these molecules against SARS-CoV-2 infections.
Podium #2 Yasamin Mohammadi, OMSIII
10:45-11:00 am Student
Kansas City University
Title: Rare Hemoglobin variant incorrectly elevating A1C levels leading to misdiagnosis of diabetes
mellitus
Author(s): Kamboj, R., Mohammadi, Y., Satish, B.
Affiliation: Kansas City University
Abstract: Hemoglobin A1c (HbA1c) assay is used as an accurate way to diagnose Diabetes mellitus
(DM), assess the effects of diabetic medications, and as a measurement of long-term glycemic control1.
However, HbA1c levels can be falsely decreased in conditions with elevated cell turn over, such as
hemolytic anemias, or blood cell transfusions2. Certain hemoglobinopathies can also impair the HbA1c
assay accuracies.There have been a number of reports of documented cases of known hemoglobin
variants in diverse populations of the world3. As further advances are made in technology, there can be
further light shed on the make-up of these variants. Here we present a case of a hemoglobin variant,
Hgb Wayne, in a 61 year old white woman in the United States. She presented to the ED with elevated
HbA1c that was found to remain elevated on repeat testing and found to be discordant with her normal
to slightly elevated point-of-care blood glucose testing. Upon review of the literature and special
investigation by the laboratory, the patient was found to have the rare hemoglobin Wayne’s variant
known to falsely elevate the hemoglobin A1c. The authors hope that this study will shed light on this
rare variant as it can lead to potentially deleterious effects on patients and their health in the event of
misdiagnosis.
Podium #3 Natalie Pardo, MPH
11:00-11:15 am Student
College Of Osteopathic Medicine, California Health Sciences University
Title: Multisystem Inflammatory Syndrome in Children (MIS–C): Case Report of 10-year-old Boy.
Author(s): N. Pardo, MPH S. Espalin, MD S. Kadavakollu, PhD, MSc
Affiliation: CHSU COM
Southwest Pediatrics
CHSU COM
6Abstract: Multisystem inflammatory syndrome in children (MIS-C) is a rare multisystem inflammatory
disease documented in children with Coronavirus disease 2019 (COVID-19) severe infection or positive
exposure. A 10-year-old boy with a history of previous COVID-19 infection presented to his pediatrician
with fever, bulbar conjunctivitis, chest pain, abdominal pain, diarrhea, rash on bilateral arms and
chest, dizziness, and difficulty ambulating. Upon admission, his laboratory studies revealed elevated
inflammatory markers. His echocardiogram demonstrated mildly diminished left ventricular systolic wall
motion, dilated left main coronary artery, echobright right and left coronary arteries, and trivial posterior
pericardial effusions. These findings were determined to be consistent with MIS-C case criteria. He
was subsequently treated with intravenous immunoglobulin (IVIG) for his inflammatory condition and
low-dose Aspirin for thromboprophylaxis. After 24-hours, he became afebrile and clinically improved.
At discharge, he was prescribed low-dose Aspirin for his coronary artery dilation, placed on exercise
restriction for 3 months, and recommended follow-up with the cardiologist 2 weeks post-discharge. At
follow-up, his improved health allowed for a gradual reintroduction of physical activity with restricted
strenuous physical activity. In 6 months, cardiology will reevaluate. Due to the novelty of MIS-C and
COVID-19, there is a research gap regarding long-term sequelae. The NIH and the National Heart,
Lung, and Blood Institute have funded the “Long-Term Outcomes after the Multisystem Inflammatory
Syndrome In Children,” a 5-year cohort study of 600 children in the U.S. and Canada in order to gain a
better understanding of the long-term effects of MIS-C.
Podium #4 Rahil Khasgiwale, MS
11:15-11:30 am Student
College of Osteopathic Medicine, California Health Sciences University
Title: Leg Movement Rate Pre- and Post-Kicking Intervention
in Infants with Down Syndrome
Author(s): Rahil N. Khasgiwale, Beth A. Smith Ph.D., and Julia Looper Ph.D.
Affiliation: Division of Biokinesiology and Physical Therapy, University of Southern California, Los
Angeles, California, USA; Division of Research on Children, Youth, and Families, Children’s Hospital Los
Angeles, Los Angeles, California, USA; Department of Pediatrics, Keck School of Medicine, University of
Southern California, Los Angeles, California, USA; School of Physical Therapy, University of Puget Sound,
Tacoma, Washington, USA
Abstract: Aim: Children with Down syndrome (DS) have delayed development and atypical movements
including kicking. We hypothesized that a kicking intervention would significantly increase leg movement
rate.
Methods: Nine infants, 3–5 months old, with DS used a commercially available toy that encouraged
kicking. The intervention was administered in their home for 20 minutes, 5 days a week, for 8 weeks. Leg
movement rate was measured using Opal wearable sensors before and after the intervention. At post-
test, a secondary analysis compared infants with DS to infants with typical development (TD).
Results: Average leg movement rate increased significantly from pre to post-intervention, from 2253 to
2645 movements per hour of awake time (p ¼ 0.049). Compared to data from nine infants with TD,
infants with DS had a significantly lower movement rate post-intervention (p ¼ 0.002).
Conclusion: The infants with DS demonstrated a higher leg movement rate following an in-home kicking
intervention.
Podium #5 Hany Ibrahim, MD
11:30-11:45 am Faculty
College of Osteopathic Medicine, California Health Sciences University
Title: Educate to Motivate! Exploring the application of Self Determination Theory to Motivate Adult
Learners
Author(s): H. Ibrahim, MD
Affiliation: California Health Sciences University College Of Osteopathic Medicine
Abstract: Motivation is essential to supporting and sustaining effective learning. Generally, motivated
learners are more energized and engaged in the learning process. There are several benefits to educating
motivated learners including increased engagement, reduced anxiety, enhanced sense of collaboration
and higher levels of creativity.
7We have experience in educating millennials for many years now, but we are just starting to see post-
millennials (Gen Z) enter the higher education scene, so it is critical to understand the characteristics of
this generation to continue driving the motivation of our adult learners and to help them improve their
academic achievement.
This presentation will define the Self-Determination Theory of motivation, particularly its three
components; Competence, Relatedness and Autonomy, compare between intrinsic and extrinsic
motivation, and discuss examples to demonstrate the applications of this theory to motivate adult
learners in active learning environments.
Podium #6 Francis Dournayan, OMS-III
11:45-12:00 pm Student
Kansas City University
Title: Assessing the impact of interprofessional education sessions on the attitudes toward and
understanding of bioethics and disclosing medical error
Author(s): C. Campat, F. Dournayan, K. Helm, A. VanGarsse, MD
Affiliation: Kansas City University/California Health Sciences University
Abstract: As the medical field becomes more specialized, members of an interdisciplinary team must be
able to communicate and work together effectively. This is especially important in the cases when ethical
dilemmas arise as team members from different disciplines may have opposing views on the correct
course of action. Developing these skills early in one’s career allows adequate time for these skills to
mature and flourish. This research explores the attitudes and impact that interprofessional education
(IPE) sessions surrounding ethical dilemmas can have on medical and pharmacy students. We conducted
a pre-post observational study via surveys filled out by the students immediately before and after an
IPE session about the ethics and process of disclosing medical error. Our results show that a single IPE
session can both increase a student’s understanding of ethical principles and dilemmas (Poptimum dose for subsequent experiments. RT-qPCR was also carried out on capsaicin-treated OVCAR8
cells to determine the expression of cytokines that are known to play a role in tumor immunogenicity.
Our results indicate that capsaicin imparts a dose dependent cytotoxic effect on OVCAR8 with IC50
of 110uM. Further, we observed that capsaicin treatment (100uM) altered the expression of innate
immunogenic cytokines such as IL-1β, TNF, IRF7 and IL-6. Capsaicin treatment may chemosensitize the
HGSOC by altering the milieu of cytokines involved in innate immunity. Activation of the innate immune
system may serve as a bridge to an adaptive immune response to combat resistant ovarian cancer.
Poster #3 Leanne Coyne, PhD
Faculty
College of Osteopathic Medicine, California Health Sciences University
Title: Faculty Job Satisfaction in Pharmacy Schools that Utilize Team-Based Learning
Author(s): Leanne Coyne, Peter Clapp, David Romerill, Leslie Ochs, Jody Takemoto
Affiliation: California Health Sciences University College of Osteopathic Medicine; Regis University School
of Pharmacy; Ben and Maytee Fisch College of Pharmacy, The University of Texas at Tyler;
University of New England College of Pharmacy
Abstract: Team-Based Learning (TBL) has been implemented as the primary teaching modality in several
US pharmacy schools, however no studies have evaluated the impact of these environments on faculty.
This study aimed to evaluate instructor perceptions of their workload, work-life balance, distribution of
responsibilities, professional development, collaboration, and overall enjoyment of their faculty role.
Faculty at US colleges of pharmacy were eligible to participate in this survey-based study. Data was
collected using a questionnaire developed by the investigators in Qualtrics. 33 instructors responded
to the survey, including 27 who primarily teach using TBL and 6 who use other methods. Participants
who primarily use TBL responded similarly to participants who do not use TBL in questions relating to
workload, work preferences and time spent preparing for class. Interestingly, instructors who do not use
TBL attended more professional development workshops relating to teaching than those who primarily
use TBL. Instructors who do not use TBL reported more frequent work-related collaborations but
socialized with colleagues less frequently than instructors who primarily use TBL. Although instructors
who use TBL as their primary teaching modality reported that they feel more connected, work better
with and enjoy collaborating with their faculty colleagues than non-TBL instructors, overall job
satisfaction appeared to be higher for instructors who do not use TBL. Although a primary limitation of
this study was the low response rate from non-TBL instructors, this study did reveal that some faculty are
not satisfied with using TBL as their primary instructional modality. This is important for administrators
to consider when considering migrating to a program wide TBL model.
Poster #5 Karen Fong, MD
Resident/Fellow
Adventist Health
Title: Spiritual Care in the Hospital Setting: S.O.U.L. Rounds revisited
Author(s): K. Fong, C. Golez
Affiliation: Resident, Faculty
Abstract: Introduction
An increasing body of research shows that spiritual care enhances medical care by improving patient’s
quality of life, enhancing their recovery and improving their coping skills, regardless of their physician’s
religious beliefs. It also elevates the physician’s personal growth and resiliency. Despite this, physicians
lack confidence in giving spiritual care to patients. S.O.U.L. rounds, or “Sharing Ourselves, Uniting Lives”,
is a strategy of the Adventist Health Hanford Family Medicine Residency Program to provide resident
training in spiritual care, in line with Adventist Health’s mission to live God’s love by inspiring health,
wholeness and hope. It mirrors the format of “Love Rounds,” a part of the curriculum of Loma Linda
University Family Medicine Residency, of which our program was affiliated with. Objective The objective
of this presentation is to propose an innovation to integrate spiritual care in the curriculum for Inpatient
Care in the light of the Covid-19 pandemic. Method Historically, S.O.U.L. Rounds was conducted in
person on a monthly basis, with the residents and faculty present at patient’s bedside during the patient
interview. The interviews were conducted by the primary team residents and facilitated by a faculty
9member, while other residents observed. The CLEAR Method, short for “Connect, Listen, Exposure,
Acknowledge, Review resources and empower” was used to guide patient interviews. Questions asked
during the patient interview included: “Tell us the story of your illness”, “How do you feel about being
in the hospital”, “What do your friends and family love about you?”, etc. After Rounds, the group leaves
the patient room and debrief.
Poster #7 Katie Hoskins, MLS, MEd
Faculty
California Health Sciences University
Title: Trends In Osteopathic Medical Education: A Scoping Review Protocol
Author(s): Katie Hoskins
Affiliation: California Health Sciences University
Abstract: A multi-state team of medical librarians developed a scoping review protocol in order to assess
prominent trends in undergraduate and graduate osteopathic medical education, and identify opportunities
for further research. Learn the difference between a scoping review and a systematic review, what a search
protocol includes, and how librarians can provide expert support before and after you start your review.
Poster #9 Rabia Kamboj, OMSIII
Student
Kansas City University
Title: Evaluation of the Osteopathic Core Competencies of Medical Students, the Core Entrustable
Professional Activities, and the COMLEX-USA Master Blueprint in the Development of Knowledge, Skills,
and Abilities of Osteopathic Medical Students
Author(s): Kamboj, R. Shank, E., Vu, P. Paulson, J.
Affiliation: Kansas City University
Abstract: Most clinical education assessments of knowledge, skills, and abilities in medical schools are
based on standard guidelines provided by the Association of American Medical Colleges (AAMC) and
the American Association of Colleges of Osteopathic Medicine (AACOM). However, one of the medical
students’ biggest concerns is identifying what they need to learn in regards to their clinical education,
national board examinations, and for residency training. Our research compares three documents,
the Osteopathic Core Competencies of Medical Students (OCCMS), the Core Entrustable Professional
Activities (EPAs), and the COMLEX-USA Master Blueprint, with the top 50 diagnoses most commonly
reported to one of the major insurance company’s Midwest region in the United States. The purpose
of this study was to compare whether these three documents provided substantial guidelines to train
medical students to become competent resident physicians, and eventually clinicians. In our review,
we found that none of the documents specifically mentioned the importance of the top diagnosis of a
routine exam.
Poster #11 Theresa Kim, MD
Resident/Fellow
Kaweah Delta
Title: Case Report: Acute Pancreatitis Following Administration of the COVID-19 Vaccine
Author(s): T Kim, K Sokol
Affiliation: Kaweah Delta Healthcare District
Abstract: Introduction: Several vaccines have been linked to the development of acute pancreatitis,
which in turn can have significant morbidity and mortality.
Case Report: In this article, we present a woman who unfortunately developed acute pancreatitis several
hours after receiving her first dose of the BNT162b2 mRNA vaccine for the coronavirus disease of 2019
(COVID-19), without any other clear cause of her pancreatitis, such as the more common conditions of
cholelithiasis and heavy alcohol use.
Conclusion: To our knowledge, this is the first case of pancreatitis following administration of this specific
vaccine, and it is therefore essential to document its occurrence.
Keywords: Post-vaccine pancreatitis, case report, COVID-19 vaccine
Poster #13 Rosie Kumar
10Student
College of Osteopathic Medicine, California Health Sciences University
Title: A Case Report of Ogilvie’s Syndrome in a 58-year-old
Quadriplegic
Author(s): R. Kumar, B. Cowan, M.D., D. Quesada, M.D., S. Wexner, M.D.
Affiliation: Kumar- CHSU, Kern Medical, Cowan- Kern Medical, Quesada- Kern Medical, Wexner- Kern
Medical
Abstract: Ogilvie’s syndrome (acute colonic pseudo-obstruction) is a rare disorder characterized by an
acute dilation of the colon measuring greater than 10 centimeters. Common symptoms associated with
Ogilvie’s include abdominal distension, abdominal pain, nausea, vomiting, constipation, and diarrhea.
This report presents an uncommon case of a quadriplegic presenting to the emergency department
with complaints of abdominal distention. Computed tomography and radiographic imaging studies
were consistent with Ogilvie’s syndrome. The patient was admitted to the hospital and started on stool
softeners and bowel rest with resolution of symptoms.
Poster #15 Benfie Liu, MS, DO
Resident/Fellow
Kaweah Delta Hospital
Title: Patient Care Advocates Impact in the Emergency Department
Author(s): B. Liu, Y. Yan, T. Evans, S. Seng
Affiliation: Kaweah Delta Graduate Medical Education: Emergency Medicine Residency 2. University of
California Merced Biostatistics 3. Vituity Healthcare
Abstract: Background: Kaweah Delta’s Emergency Department (ED), located in Visalia, California,
utilizes patient care advocates (PCA) to help connect patients after their ED visit with their primary care
physician. From November 2018-February 2021, 5,464 patients were identified for navigation with an
average of 195 patients every month.
Objectives: Identify the impact of the patient care advocate program on reducing return ED visits.
Methods: Three comparison groups with 143 patients each were made from patients visiting the ED
between April 2019 and January 2020. Group 1) Patient care advocate made patient’s appointment
(PCA). Group 2) Patient made appointment themselves (PAT). Group 3) Patient did not make any
appointment or did not answer PCA calls (NA). Crosstabulation, chi-square tests, and analysis of variance
were used to analyze demographic or outcome variables. Poisson and logistic regression examined
associations with return ED visits.
Results: Patients with a higher number of historic ED visits in the past 6 months had more recurrent visits
in 72 hours (5.5 vs. 3.6, pscaring in response to ocular trauma. In this report we describe a 43-year-old, hypermobile female
patient with a heterozygous missense mutation (Pro365Leu) in ZNF469; a transcriptional factor involved
in Collagen I synthesis and associated with Brittle Cornea Syndrome and keratoconus. The patient
underwent a superficial keratectomy approximately three months after suffering a non-healing corneal
abrasion and developed post-surgical chronic corneal erosion. The pathophysiology of EDS within the
context of the specific molecular defect is discussed as are the history, clinical features, genetic testing,
and ophthalmologic management considerations.
Poster #19 Saumya Shah, BA
Student
College of Osteopathic Medicine, California Health Sciences University
Title: A Comparison of BMI and Treatment Modalities in Obese Pediatric Patients Based on Insurance
Author(s): S Shah, T Van Es, A VanGarsse, MD
Affiliation: California Health Sciences University College of Osteopathic Medicine
Abstract: Introduction: Central California is among the world’s largest producers of nutrient-rich foods,
yet this region sees higher rates of pediatric obesity compared to the national average. This is especially
true in rural agricultural towns where the majority of families are immigrants of Mexican heritage. The
goal of this study is to analyze pediatric patient data in two rural agricultural towns where the Hispanic
population alone makes up more than 75%. We plan to analyze the impact of the type of insurance
(government-funded or private) and different treatment modalities used (medication, surgical, or
lifestyle intervention) on preventing and improving health outcomes.
Methods: This will be a retrospective, multicenter study where two Aventist Health pediatric outpatient
clinics in Dinuba, CA and Reedley, CA will be conducting a pooled analysis between data collected from
both sites. Patients under the age of 18, with a confirmed BMI at or above the 95th percentile for age,
gender, and height will be included in the sample. Each treatment modality will be split into two groups
(government-funded vs privately insured).
Results and Discussion: We expect to find a significant difference in the prevalence of obesity among
both insurance types in each group. Specifically, we believe pediatric patients with government-funded
insurance plans, will have poorer health outcomes compared to those in the same treatment group.
Poster #21 Stephanie Songey, D.O.
Resident/Fellow
Kaweah Delta Health Care District
Title: Posterior Sternoclavicular Dislocation: A Case Report
Author(s): S Songey, DO*, C Goodwill, DO* and K Sokol, MD, MS, MACM*
Affiliation: *Kaweah Delta Medical Center, Department of Emergency Medicine, Visalia, CA
Abstract: Posterior sternoclavicular dislocations are very rare and pose immediate threat to mediastinal
structures should a patient sustain this type of injury. This case report discusses the presentation
and diagnosis of a young male who presented with isolated right arm swelling after blunt trauma
one day prior while participating in a bull riding rodeo event. He was diagnosed with posterior right
sternoclavicular joint dislocation with compression of the left brachiocephalic vein that was seen on
computed tomography (CT) angiogram study. Patient was transferred to a tertiary care center for a
higher level of care and definitive reduction management. Any history of blunt shoulder trauma or
direct sternoclavicular trauma with symptoms to suggest compression of mediastinal structures should
make one suspicious for posterior sternoclavicular dislocation. Evaluation is best made by computed
tomography (CT) scan. Reduction should be performed by an orthopedic surgeon in the operating room
with cardiothoracic surgery available for any vascular compromise that may occur.
12Poster #23 Linh Tran, MD
Resident/Fellow
Kaweah Delta Health Care District
Title: Increasing the Percentage of Specific Asthma Diagnoses in a Residency Clinic
Author(s): Linh Tran
Affiliation: Kaweah Delta Health Care District
Abstract: Background: Non-specific diagnoses such as “asthma” do not indicate disease severity, and
make it difficult to assess whether or not patients are on the appropriate control regimen.
Hypothesis: A reference card for asthma severity classification placed at each workstation in the
residency clinic will increase the percentage of documented specific asthma diagnoses.
Methods: Asthma reference cards were placed at all workstations in the Sequoia Health and Wellness
Centers (SHWC) residency clinic without explanation.
The Cerner Dynamic Worklist and its filters were used to generate a list of SHWC patients aged 5-65
years-old that had received a diagnosis of “asthma” at any point and were seen in the clinic from June 4,
2020 to July 27, 2020. The most recent clinic note for the visit that occurred just before the study period
was also assessed to see if the specific asthma diagnosis was updated from an unspecified diagnosis of
“asthma”.
Results: Prior to intervention, 20 out of 61 charts (32.8%) had specific asthma diagnoses. After the
intervention, 24 out of 61 charts (39.3%) had specific asthma diagnoses.
Discussion: The percentage of specific asthma diagnoses increased by 6.5% after the intervention period.
Limitations to the study include a brief study period and consequently small sample size.
To further increase the percentage of specific asthma diagnoses in the residency clinic, an additional
verbal announcement could be made to remind/educate residents on utilizing specific asthma diagnoses.
An announcement was not done for this project so that the effects of a single intervention (the asthma
reference card) could be measured.
Poster #25 Rahil Khasgiwale, MS
Student
College of Osteopathic Medicine, California Health Sciences University
Title: Leg Movement Rate Pre- and Post-Kicking Intervention
in Infants with Down Syndrome
Author(s): Rahil N. Khasgiwale, Beth A. Smith Ph.D., and Julia Looper Ph.D.
Affiliation: Division of Biokinesiology and Physical Therapy, University of Southern California, Los
Angeles, California, USA; Division of Research on Children, Youth, and Families, Children’s Hospital Los
Angeles, Los Angeles, California, USA; Department of Pediatrics, Keck School of Medicine, University of
Southern California, Los Angeles, California, USA; School of Physical Therapy, University of Puget Sound,
Tacoma, Washington, USA
Abstract: Aim: Children with Down syndrome (DS) have delayed development and atypical movements
including kicking. We hypothesized that a kicking intervention would significantly increase leg movement
rate.
Methods: Nine infants, 3–5 months old, with DS used a commercially available toy that encouraged
kicking. The intervention was administered in their home for 20 minutes, 5 days a week, for 8 weeks. Leg
movement rate was measured using Opal wearable sensors before and after the intervention. At post-
test, a secondary analysis compared infants with DS to infants with typical development (TD).
Results: Average leg movement rate increased significantly from pre to post-intervention, from 2253 to
2645 movements per hour of awake time (p ¼ 0.049). Compared to data from nine infants with TD,
infants with DS had a significantly lower movement rate post-intervention (p ¼ 0.002).
Conclusion: The infants with DS demonstrated a higher leg movement rate following an in-home kicking
intervention.
Poster #27 Hany Ibrahim, MD
Faculty
College of Osteopathic Medicine, California Health Sciences University
Title: Educate to Motivate! Exploring the application of Self Determination Theory to Motivate Adult
Learners
13Author(s): H. Ibrahim, MD
Affiliation: California Health Sciences University College of Osteopathic Medicine
Abstract: Motivation is essential to supporting and sustaining effective learning. Generally, motivated
learners are more energized and engaged in the learning process. There are several benefits to educating
motivated learners including increased engagement, reduced anxiety, enhanced sense of collaboration
and higher levels of creativity. We have experience in educating millennials for many years now, but
we are just starting to see post millennials (Gen Z) enter the higher education scene, so it is critical
to understand the characteristics of this generation to continue driving the motivation of our adult
learners and to help them improve their academic achievement. This presentation will define the Self-
Determination Theory of motivation, particularly its three components; Competence, Relatedness and
Autonomy, compare between intrinsic and extrinsic motivation, and discuss examples to demonstrate
the applications of this theory to motivate adult learners in active learning environments.
Poster #29 Francis Dournayan, OMS-III
Student
Kansas City University
Title: Assessing the impact of interprofessional education sessions on the attitudes toward and
understanding of bioethics and disclosing medical error
Author(s): C. Campat, F. Dournayan, K. Helm, A. VanGarsse, MD
Affiliation: Kansas City University/California Health Sciences University
Abstract: As the medical field becomes more specialized, members of an interdisciplinary team must be
able to communicate and work together effectively. This is especially important in the cases when ethical
dilemmas arise as team members from different disciplines may have opposing views on the correct
course of action. Developing these skills early in one’s career allows adequate time for these skills to
mature and flourish. This research explores the attitudes and impact that interprofessional education
(IPE) sessions surrounding ethical dilemmas can have on medical and pharmacy students. We conducted
a pre-post observational study via surveys filled out by the students immediately before and after an
IPE session about the ethics and process of disclosing medical error. Our results show that a single IPE
session can both increase a student’s understanding of ethical principles and dilemmas (Psection of the progress note for that visit. This study was reviewed by Glendale IRB and was certified as
approved Exempt Category 4 on October 23, 2019.
Results. A total of 211 charts were reviewed for 2018 and 221 for 2019. Findings included: Paps, 50
due and 4 scheduled in 2018 vs 43 due and 4 scheduled in 2019; Mammograms, 26 due and 2 ordered
in 2018 vs 39 due and 14 ordered in 2019; colorectal cancer (CRC) screening, 36 due and 5 ordered/
referred in 2018 vs 68 due and 21 ordered/scheduled in 2019; pneumococcal vaccine, 8 due and 0
ordered in 2018 vs 21 due and 7 ordered in 2019; influenza vaccine, 164 due and 57 ordered in 2018
vs 157 due and 61 ordered in 2019. Chi-square and Fisher’s Exact test were used for statistical analysis.
Only mammogram ordering showed statistical significance (pJohnston, PhD, MPH, RDN, CDE; Sara Goldgraben, MD, MPH, MBA
Affiliation: California Health Sciences University College of Osteopathic Medicine
Abstract: While it is expected that nutrition will be a central focus for healthcare in the future, many
healthcare providers find it difficult to confidently counsel their patients on healthy eating habits. This
is primarily due to a lack of adequate nutritional training, which often results in the provider electing to
defer to costly or unavailable specialists instead of taking the lead in providing nutrition counseling. As a
result, a fertile opportunity is missed to prevent and mitigate diseases, to improve healthcare outcomes,
and reduce rising health care costs. Medical school provides a favorable environment to incorporate
culinary and nutrition education prior to practice. This highlights the need to discuss the obstacles to
integrate nutrition education into medical school curricula.
The College of Osteopathic Medicine at California Health Sciences University assessed and recognized
the need for developing strategies to allow for hands-on culinary education to be incorporated in its
curriculum for a smoother transition of nutrition science to clinical practice.
Securing adequate resources to build an on-campus teaching kitchen and effectively integrating nutrition
into the medical school curriculum is critical for promoting the well-being of students and empowering
them with tools to truly embrace the osteopathic philosophy by holistically evaluating and treating their
future patients. The teaching kitchen provides an opportunity for delivering hands-on experiences in
culinary medical courses and community seminars to provide evidence-based recommendations to a
wide range of audiences including students, faculty, patients, and interested community members.
Poster #10 Rabia Kamboj, OMSIII
Student
Kansas City University
Title: Establishing a Limb Preservation Program in a Rural Hospital: Successes and Challenges
Author(s): Kamboj, R. Yerokun, O.
Affiliation: Mercy Hospital, Joplin
Abstract: A multidisciplinary approach to the management of patients with threatened limbs has been
shown in a variety of settings to reduce the number of non-trauma related major lower extremity
amputations. Reduced amputations helps improve key healthcare quality parameters including overall
healthcare cost, length of hospital stay, morbidity and mortality. In rural clinical settings, there are
several challenges to ensuring that the critical disciplines are accessible to provide the necessary services
for limb preservation. Providers at a single center rural hospital sought to create a multidisciplinary limb
preservation program with the goal of improving provider knowledge, interdisciplinary communication,
and overall patient outcomes. We developed a regularly scheduled collaboration of providers involved
in limb preservation. The providers were surveyed at each meeting for areas of educational and process
improvement. Hospital data on the number of major amputations prior to and after the beginning of
the Limb preservation program were reviewed. We found that we were able to successfully create a
limb preservation program which improved interdisciplinary communication and provided beneficial
educational opportunities for attendees. A sustainable limb preservation program may help reduce the
major lower extremity amputation rate and improve overall patient outcomes in rural clinical settings.
Poster #12 Jason Kim, BA, PharmD and William Kim, BS
Students
College of Osteopathic Medicine, California Health Sciences University
Title: Motivating High School Students From Rural Areas to Attend College and Pursue Careers as
Osteopathic Physicians
Author(s): S Kadavakollu, R S Shindi, H R Nummerdor, V K Singh, S B Pillai, S J Ontiveros, B Boyanovsky
A ilia ion: S Kadavakollu (CHSU COM), R S Shindi (New Mexico State University), H R Nummerdor, V K
Singh (F Edward Hebert SOM), S B Pillai, S J Ontiveros (Burrell COM), B Boyanovsky (CHSU COM)
Abstract: To healthcare professionals, rural areas elicit an unanimous consensus: that these areas are
medically underserved. There are many studies conducted demonstrating that rural communities have
deficits in their quality of healthcare, but few studies have directly evaluated the efficacy of motivating
the younger generation of these communities to pursue higher education in healthcare. We conducted a
study with 116 students in a rural area with 150 hours of interactive lectures and laboratories, and
16after the study, students were motivated to pursue higher education. We evaluated these motivations
by utilizing the Likert scale and blinded ACT scores for confirmation. Looking forward, we believe that
inspiring rural high school students to pursue higher education in healthcare will improve retention rates
of healthcare professionals in these medically underserved areas, and bring the quality of healthcare
that these communities deserve.
Poster #14 Mike Lim
Student
Kansas City University
Title: Case report of 59-year-old male with unilateral hydronephrosis of unknown etiology
Author(s): M Lim, C Liu, M Lau, R Arora
Affiliation: M Lim, C Liu, M Lau - Kansas City University
R Arora - California Health Sciences University
Abstract: Unilateral hydronephrosis presents as an uncommon feature in adults. Causes of unilateral
hydronephrosis in adults often involve central obstruction proximal to the attachment of the ureter
to the bladder. Here, a 59-year-old man with past medical history of uncontrolled diabetes mellitus,
hypertension, hyperlipidemia, and benign prostatic hyperplasia presented to a rural outpatient internal
medicine clinic after referral from a PA-C due to poor kidney function and secondary hypertension.
Physical examination showed no signs of infection, no flank pain, nor dysuria. Urinalysis showed 3+
protein and 3+ glucose, and a complete metabolic panel showed eGFR 26, BUN 34, and creatinine
2.55, suggesting acute kidney injury. Retroperitoneal ultrasound was conducted, indicating right kidney
hydronephrosis. With scheduling delays from the COVID-19 pandemic, a nuclear medicine renal flow
study was performed, showing no flow or function in the right kidney, and normal function and flow in
the left kidney. Alongside nuclear medicine studies, a CT scan on the same day indicated end-stage right
renal hydronephrotic sac with moderate left renal parenchymal scar formation. At this time of writing
this report, a urologist was consulted to schedule the patient for right kidney nephrectomy and workup
for potential etiology. The etiology of our patient’s unilateral hydronephrosis was puzzling. This case
presents a spontaneous manifestation of unilateral hydronephrosis uncharacteristically seen in patients
with acute kidney failure. Furthermore, the nature of rural medicine combined with the impact of the
COVID-19 pandemic provides a glimpse of an amplified, delayed struggle to fulfill the critical healthcare
needs of underserved patients with limited access.
Poster #16 Daniela Rangel Orozco, MD, MPH
Resident/Fellow
Kaweah Delta Health Care District
Title: Acute Interstitial Nephritis After Phentermine Use
Author(s): D. Rangel Orozco MD, T. Javed, MD
Affiliation: Kaweah Delta Health Care District
Abstract: There is a long list of drugs associated with AIN and one that does not often make the
published list is Phentermine. Phentermine is one of the most commonly prescribed weight loss
medications in the U.S. and is indicated as a short-term adjunct to a multimodal weight loss plan.
We report a case of Drug-induced AIN in a Latina woman aged 22 years who presented with back
and abdominal pain, nausea, vomiting and unable to tolerate oral intake. She took phentermine for
two weeks consecutively and then intermittently four months prior to presenting to the emergency
department. Renal biopsy pathology results were consistent with pathological findings of AIN including
interstitial inflammation, edema, and lymphocytic infiltrates. Our case adds to the data of two additional
reported cases of AIN in the literature resulting from phentermine use alone and a second case resulting
from the combination of phentermine and phendimetrazine. This begs the question of whether
phentermine induced AIN is more common than previously thought but simply has not been widely
identified and reported. We recommend that primary care providers prescribing phentermine should
take a thorough history prior to prescribing the medication to assess for any possible predisposing
factors to AKI, personal or family history of any renal dysfunction, obtain baseline renal panels and trend
renal function while patients are on phentermine.
17Poster #18 Saumya Shah, BA
Student
College of Osteopathic Medicine, California Health Sciences University
Title: Treatment responses in drug-resistant juvenile myoclonic epilepsy: valproate resistance may not be
the end of the road
Author(s): S Shah, BA (1), H Veedu, MD (2), N Baheti, MD(3), C Rathore, MD (4), A Bansal, MD (5),
S Prakash, MD (3), K Kanhere (3), MS, S Jaiswal, MD (6), A Jukkarwala, MD (7), J Murthy, MD (6), K
Radhakrishnan, MD (8)
Affiliation: (1) California Health Sciences University College of Osteopathic Medicine, Clovis, CA
(2) Medical Institute of Central California & Kern Medical Outpatient Clinic, Bakersfield, CA
(3) Department of Neurology, Dr. G. M. Taori Central India Institute of Medical Sciences, Nagpur, India
(4) Department of Neurology, Smt. B. K. Shah Medical Institute and Research Center, Sumandeep
Vidyapeeth, Vadodara, India
(5) Department of Neurology, Medanta-Medicity Hospital, Gurugram, India
(6) Department of Neurology, Care Hospitals, Hyderabad, India
(7) Department of Neurology, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India
(8) Department of Neurology, Avitis Institute of Medical Sciences, Kerala, India
Abstract: Aim: To study the seizure outcome and responses to various anti-seizure medicine (ASM) trials
in patients with drug-resistant juvenile myoclonic epilepsy (DRJME).
Methods: We reviewed the records of all the patients with juvenile myoclonic epilepsy (JME) who
attended epilepsy clinics at 3 Indian and 2 US centers during a 5-year period. We used International
Consensus Criteria to diagnose JME and International League Against Epilepsy (ILAE) definition to define
drug resistance and sustained seizure freedom. We considered an ASM or combination successful if the
patient achieved seizure freedom within 3 months of attaining the maintenance dose.
Results: We studied 116 patients (61 males; 55 females) with DRJME. At the last follow-up visit, 91 (78%)
patients became seizure-free after a median duration of 8 (2-33) years. In patients where valproate failed
as first or second-line drug (n=70; 60.3%), 55(78%) became seizure-free. In this seizure-free group, the
addition of lamotrigine produced seizure freedom in 37 (67.3%) patients. The success rate of lamotrigine
and valproate combination was 77% as compared to 9% with all other combinations (p = 0.0001). In
patients who were not exposed to valproate as initial therapy (n=46), 36 (78%) became seizure-free, of
which, 33 (92%) after adding valproate. At the last follow-up visit, 85 (93%) seizure-free patients were
receiving valproate including 49 (54%), receiving a combination of valproate and lamotrigine. Only one of
16 patients became seizure-free after failing the combination of valproate and lamotrigine.
Conclusion: Seizure freedom can be achieved in three-fourths of patients with DRJME. A combination of
valproate and lamotrigine is the most effective ASM duotherapy.
Poster #20 Anitha Shenoy, PhD
Faculty
College of Pharmacy, California Health Sciences University
Title: Canonical Wnt Signaling Promotes Vascular Destabilization and Metastasis in Breast Cancer by
Directly Activating Angiopoietin-2 Expression
Author(s): Anitha Shenoy, Jianrong Lu
Affiliation: California Health Sciences University
Abstract: Metastasis is the primary reason for Breast Cancer (BC) related deaths. Though BC is diagnosed
and treated at an early stage, BC patients are at an increased risk of developing sudden metastases
many years later. Initial steps of metastasis involve transmigration of cancer cells across the vascular
endothelial cell (EC) layer and depend on the interplay between cancer cells and ECs that results
in destabilization of blood vessels. We found that Wnt5A is upregulated in metastatic BC cell lines
compared to the normal and non-metastatic ones. Also, the Wnt receptor, Frizzled 4 (Fzd 4), was highly
upregulated in Human microvascular endothelial cells (HMVECs), implying the Wnt pathway-activation
in the ECs of BC. To determine the effect of Wnt pathway activation on ECs, we evaluated the gene
expression of various factors involved in vascular remodeling in the Wnt pathway-activated HMVECs. We
found a 12-fold increase in Angiopoietin-2 (Ang-2) gene in Wnt pathway-activated HMVECs compared to
the control. Through Chromatin Immunoprecipitation (CHIP) assay, we confirmed that Ang-2 is the direct
18target of the Wnt pathway. We also performed a transendothelial migration assay using RFP labeled
metastatic BC line Hs578T through Wnt pathway-activated and control HMVECs. Increased Hs578T-RFP
cells migrated through the Wnt pathway-activated HMVECs compared to the control. Overall our results
show that Ang-2 is the direct target of the Wnt pathway, which plays a pivotal role in the destabilization
of the vasculature, promoting metastasis. Further studies will provide insights into the development of
novel therapeutics targeting the Wnt pathway and/or Ang-2 to prevent metastasis in BC patients.
Poster #22 Kevin Steed, PhD
Faculty
College Of Osteopathic Medicine, California Health Sciences University
Title: Impact of service-learning participation on volunteers’ academic and personal development
Author(s): Kevin Steed
Affiliation: California Health Sciences University COM
Abstract: Abstract: Service-learning is an immersive experience that provides academic and personal
development for volunteer participants. For example, Mentors of Anatomy Academy, who reflected on
their teaching experiences in an active learning environment, noted significant improvement in qualities
of constructivism and significant learning. Through the process of teaching, Mentors learned skills that
allowed a deeper connection with their mentees and realized that their resulting increase in knowledge
applied directly to understanding real world issues. The simultaneous learning of skills and knowledge
facilitated a journey toward life-long learning that is difficult to teach in conventional classroom
environments.
Poster #24 Miho Yoshida, DO, MA
Faculty, Health Professional
College Of Osteopathic Medicine, California Health Sciences University
Title: Medical Students’ Perceptions on Changing Osteopathic Manipulative Medicine Lab Practical
Assessment Styles
Author(s): YC Wang, OMS IV
M Yoshida, DO, MA
Affiliation: Yen-Chung Jonathan Wang, OMS IV-VCOM Auburn Campus
Miho Yoshida, DO, MA, -CHSU COM
Abstract: Purpose: With the development of Osteopathic Core Competencies and Core Entrustable
Professional Activities (EPAs), there has been a shift towards competency-based curriculum in
osteopathic medical education. Medical students at the Edward Via College of Osteopathic Medicine-
Auburn campus (VCOM-Auburn); which utilizes the traditional, randomized Osteopathic Manipulative
Medicine (OMM) practical testing style; were surveyed on their preference towards an OMM practical
assessment modality to determine how receptive students would be to curricular change. The study
evaluated the learning and assessment preferences of first- and second-year osteopathic medical
students (OMS I & OMS II) at VCOM-Auburn.
Methods: Participants, regardless of sex, age, race, or academic achievement, were recruited using class
announcement and emails. A 6-question anonymous and voluntary survey was conducted via iClicker to
evaluate perception and readiness for change in OMM curriculum and assessment formats.
Results: Out of the 308 enrolled first- and second-year students, 243 responded (78.9%). Study results
found that OMS I and OMS II students selected similar choices for each question, and most students
preferred the current traditional OMM practical testing style over competency-based testing. However,
there is a significant difference in the proportion of student satisfaction and testing preference between
OMS I and OMS II classes; satisfaction with the current practical setup decreased from 82% among OMS
I’s to 68% among OMS II’s, x2(1)=5.114, p=0.024.
Conclusion: Data suggests that OMS I and OMS II at VCOM-Auburn are satisfied with the current
traditional practical assessment with a significant decrease with the increase in seniority. Previous
experience in traditional assessment may be a factor. The preference to utilize competency based
learning as medical education progresses predicts that students and residents with increased medical
education experience acknowledge the importance of a more interactive and flexible curriculum.
Therefore, this is a relevant consideration with the changes to the Single Accreditation System for
Graduate Medical Education.
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