Psychotherapy for Generalized Anxiety Disorder
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Chapter 14 Psychotherapy for Generalized Anxiety Disorder Jonathan D. Huppert, Ph.D. William C. Sanderson, Ph.D. William C. Sanderson, Ph.D. AUTHOR: 1) Below are affiliations for each chapter author Professor of Psychology, Hofstra University, Hempstead, as they will appear in the contributor list in the front of the New York book. Please review these carefully and provide any miss- ing information or updates. (This information will be UPS – William C. Sanderson, Ph.D., Department of Psy- moved to the front matter to create an alphabetical list of chology, Rutgers University, Piscataway, NJ 08854; contributors at the next stage of production.) tel.:__________ (please provide); 2) So that we may send each contributor a complimentary e-mail: wsanders@rci.rutgers.edu copy of the book on publication, please update current mailing information for each author (what we have on file is listed below). UPS requires a street address (not a P.O. box) and a phone number. Jonathan D. Huppert, Ph.D. As discussed in other chapters in this volume, gener- Associate Professor of Psychology, The Hebrew Univer- alized anxiety disorder (GAD) is a relatively common sity of Jerusalem, Mt. Scopus, Jerusalem, Israel disorder that is associated with significant distress and functional impairment. Recent advances in both phar- UPS – Jonathan D. Huppert, Ph.D., [author: is this mail- macotherapy and psychotherapy have resulted in a ing address sufficient?] Department of Psychology, Hebrew greater likelihood of providing effective treatment. University of Jerusalem, ISRAEL; tel.: 02-588-3376; fax: However, reports suggest that people with GAD re- 02-588-1159; e-mail: huppertj@mscc.huji.ac.il spond less robustly compared with those who have other anxiety disorders, which highlights the need for continued work in understanding the nature and treat- ment of GAD. In this chapter, we provide an overview of empirically based psychotherapeutic treatment of GAD. First, we briefly describe the history of psycho- social approaches to GAD, which have been predomi- 253
254 TEXTBOOK OF ANXIETY DISORDERS nantly cognitive-behavioral. Next, we elucidate the psy- the perception of potential future danger (Craske 2003) chological mechanisms associated with GAD that such as “What if I fail the licensing exam I am taking appear to be involved in the maintenance of the disorder next week and as a result I am not able to get a job?” and, thus, must be addressed in treatment. We then Worry is often accompanied by behavior directed at provide a review of the treatment outcome literature rel- gaining control to avoid the occurrence of the negative evant to GAD, and briefly review how treatment has event (Rapee 1991; e.g., “What can I do to prevent fail- been applied to special populations such as children and ing the exam?”). Indeed, the appropriate “function” of older adults. Finally, an overview of empirically sup- worry will lead one to take action to decrease the likeli- ported psychological treatment strategies is provided. hood of potential negative outcomes (e.g., increase This chapter ends with a treatment algorithm to suggest studying to avoid failing the exam), thereby decreasing what techniques to use and when to use them. the anxiety. Although worry in itself is not pathological, and is in The Nature of fact very common in the population at large, individuals diagnosed with GAD suffer from excessive worry; that Generalized Anxiety Disorder is, reporting worry most of the day, nearly every day GAD is a relatively new diagnosis, transformed from a (Brown et al. 1993; Dupuy et al. 2001). Even though “wastebasket” diagnosis pertaining to anyone with anx- worry often activates attempts at problem solving in iety whose symptoms did not meet criteria for any other nearly everyone, individuals with GAD lack confidence anxiety disorder listed in DSM-III (American Psychi- in their solutions, thereby leading to continued worry atric Association 1980) to an independent diagnosis, (Davey 1994). This raises an important issue to con- more “carved at its joints” in DSM-III-R and DSM-IV sider: if worry is a ubiquitous experience, how does it (American Psychiatric Association 1987, 1994) (see differ in individuals with GAD versus those without the also Chapter 11, “Phenomenology of Generalized Anx- disorder? There are two main aspects of pathological iety Disorder,” in this volume). Until the advent of worry that differentiate it from “normal” worry (de- DSM-III-R in 1987, the development of treatment for scriptive studies such as Ruscio and Borkovec 2004 and GAD was aimed at treating “anxious neurotics.” Two information-processing studies such as Mathews 1990 primary techniques were utilized: relaxation or biofeed- provide supportive evidence). First, pathological worry back to address physiological tension and arousal (Rice appears to be uncontrollable. In a study by Abel and and Blanchard 1982), and cognitive therapy to address Borkovec (1995), all (100%) of the patients with GAD the anxious thoughts associated with GAD (Beck described their worry as uncontrollable, in comparison 1976). Most CBT treatment protocols developed since with none of the control subjects. Second, pathological then continue to integrate these two major strategies. worry is excessive for a given situation, in that patients However, as a result of greater precision in the defini- overestimate the threat in their environment, especially tion of GAD and an increased understanding of the na- when interpreting ambiguous cues (Mathews 1990). In ture of worry and anxiety (Heimberg et al. 2004), newer fact, these two features may be the result of GAD pa- treatment protocols also include strategies to address tients’ intolerance of uncertainty, leading to more exces- these recently identified components (e.g., techniques sive and uncontrollable worry (Dugas et al. 1998). In to minimize experiential avoidance, techniques to en- addition, anxious subjects tend to selectively attend to hance problem solving). threatening, personally relevant stimuli (Mathews 1990). The overprediction of danger may lead patients Worry with GAD to worry more often than others because The diagnosis of GAD depends on the existence of two they perceive their environment as more threatening. core symptoms: worry (i.e., preoccupation with negative Frequently, the implied belief is that worry will make events occurring in the future) and physiological hyper- the world more controllable and predictable. For exam- arousal (e.g., muscle tension, sleep disturbance, feeling ple, one patient stated, “When I fly in an airplane, I keyed up). Clearly, worry is frequently the most prom- worry that the plane will crash. If I stopped worrying inent symptom of GAD and is considered the cardinal about it, it probably would crash.” Consistent with this feature of the disorder. Worry is a cognitive activity of- feature, worriers report five major functions of worry: ten referred to as anxious apprehension. It is elicited by 1) superstitious avoidance of catastrophes, 2) actual avoidance of catastrophes, 3) avoidance of deeper emo-
Psychotherapy for Generalized Anxiety Disorder 255 tional topics, 4) coping preparation, and 5) motivating Characteristics of Patients With devices (Borkovec 1994). Generalized Anxiety Disorder Research has demonstrated that pathological worry GAD is a relatively chronic disorder that begins in has a functional role for patients with GAD. Ironically, childhood (Brown et al. 1994). In view of these and worry inhibits autonomic arousal in patients with GAD other similar data, some argue that, in contrast to other when they are shown aversive imagery (Borkovec and anxiety disorders, a subtype of GAD (chronic, pervasive Hu 1990). Worrying may allow for the avoidance of symptoms since childhood) may be better conceptual- aversive imagery, the latter being associated with a ized as an underlying personality trait that increases greater emotional state (Borkovec et al. 1991). Thus, one’s vulnerability to developing anxiety disorders worry may be maintained by both the avoidance of cer- (Sanderson and Wetzler 1991). Along this line, Barlow tain affective states and the reduction of anxious states (2002) considers GAD the “basic anxiety disorder.” through the decrease in arousal that occurs along with GAD-like symptoms typically start in childhood, but worry (see Borkovec et al. 2004 for a review). Counter- often, a major stressor at some point in the individual’s intuitively, relaxation has been shown to increase the life will exacerbate symptoms and raise the condition to amount of worry in some patients with GAD (Borkovec a clinical disorder. For example, one common example et al. 1991). In these patients, relaxation may signal a of a trigger we see clinically is becoming a parent. It ap- lack of control, triggering an increase in anxiety, or these pears that the increased responsibility and desire for patients may sit quietly with their thoughts, causing perfection in child rearing may exacerbate these traits to greater exposure to their worries. the point of interference and distress. In addition, individuals with GAD often have a New conceptualizations of GAD have focused on in- heightened sense of the likelihood of negative events terpersonal deficits that may have developed in child- (i.e., increased risk perception) and often exaggerate the hood (Crits-Christoph et al. 2005; Newman et al. negative consequences that would occur (Brown et al. 2004). In fact, interpersonal difficulties and concerns 1993). Patients with GAD and control subjects appear appear to be common triggers for worry episodes. Along to worry about similar topics (Sanderson and Barlow this line, Sanderson and Barlow (1990) found that the 1990), although patients with GAD tend to worry more majority of patients with GAD suffer from clinically frequently about minor matters (Brown et al. 1994). significant social evaluative concerns. Other recent con- Spheres of worry endorsed by patients with GAD in- ceptualizations have focused on emotion regulation clude concerns about family, health, social matters, fi- problems in individuals with GAD (e.g., Mennin et al. nances, work, and world events. The topics of worry 2005). It is likely that the interpersonal and emotion may change with age and life situation. regulation deficits interact to create difficulties (e.g., Erickson and Newman 2007). Other common charac- Physiological Hyperarousal teristics of GAD patients include perfectionism, ex- In addition to worry, patients with GAD experience un- traordinary need for control in their environment, diffi- pleasant somatic sensations associated with physiologi- culty tolerating ambiguity, and feelings of increased cal hyperarousal. The presence of physiological arousal personal responsibility for negative events that occur or is seen as a component of the “fight-or-flight” response are predicted to occur in their environment (Wells that is activated by GAD patients’ perceptions of dan- 1994). ger. Although both the cognitive and the somatic sen- sations usually increase during the course of a “worry AUTHOR: Please provide a full reference to correspond to episode,” for the most part, these symptoms are rela- the above citation of Erickson and Newman 2007. tively chronic, and not limited to episodes of worry. The most common somatic symptom reported by patients with GAD is muscle tension. Other common symp- toms include irritability, restlessness, feeling keyed up or Differentiating Generalized Anxiety on edge, difficulty sleeping, fatigue, and difficulty con- Disorder From Other Disorders centrating. Accurate diagnosis is an essential first step in providing the appropriate treatment for a particular disorder. In fact, differentiating GAD from other anxiety disorders
256 TEXTBOOK OF ANXIETY DISORDERS can be extremely complicated. First, worry (or anticipa- minutes, whereas the onset and course of GAD-related tory anxiety) is a relatively generic feature of anxiety dis- anxiety are usually longer and more stable. orders (e.g., patients with panic disorder often worry about future panic attacks, patients with social anxiety Social Anxiety Disorder disorder worry about embarrassing themselves in forth- Social concerns are a common area of worry for patients coming social situations). In addition, a high level of co- with GAD, and these patients are often assigned a co- morbidity exists among the anxiety disorders, and morbid diagnosis of social phobia (Sanderson et al. GAD in particular, which requires one to consider di- 1990). For diagnosis of GAD, additional concerns be- agnosing multiple disorders to account for the full range yond the social evaluative fears must be present. As op- of psychopathology displayed by the individual (Sand- posed to the concerns of individuals with social anxiety erson and Wetzler 1991). To do this, the clinician must disorder, interpersonal concerns in individuals with distinguish between symptoms that can be subsumed GAD frequently include interactions with close friends within GAD versus those that are signs of an additional, and relatives (e.g., “Did I say something wrong to my independent disorder. The primary distinction to be wife?”) and are not as focused on rejection by others spe- made in differential diagnosis is not the presence of cifically because of inadequate content or behaviors (i.e., worry per se, but the focus of the worry. Patients with saying or doing things that are perceived as strange or GAD experience uncontrollable worry about multiple unintelligent). In contrast to patients with social anxiety areas of their life. Common worries include minor mat- disorder, the evaluative concerns of patients with GAD ters, work and family responsibilities, money, health, extend beyond fears of embarrassment. In addition, pa- safety, and the well-being of significant others. More- tients with GAD are less likely than patients with social over, patients with GAD often end up worrying about anxiety disorder to engage in significant avoidance, ei- their worry (known as metaworry; Wells 1994). We will ther overt (e.g., not going to parties, not meeting new review differential diagnostic considerations below, people, not talking to people) or social anxiety-specific with an emphasis on the distinctions that are relevant to (e.g., censoring one’s thoughts, staying on the edge of CBT treatment (see Chapter 11, “Phenomenology of groups, rehearsing sentences in one’s mind before Generalized Anxiety Disorder,” for other consider- speaking) which are focused on the prevention of nega- ations of differential diagnosis). tive evaluations and embarrassment. Panic Disorder AUTHOR: Above: 1) For clarity, should social anxiety dis- Patients with panic disorder are worried about having a order be identified as another term for social phobia? Or panic attack or about the consequences of experiencing use one or the other throughout? certain bodily sensations. Their focus is on internal states. What makes the differential diagnosis particu- 2) Sentence beginning “In addition,…” was missing a larly confusing is that the worry experienced by patients word. To fix, “significant overt avoidance” has been changed to “significant avoidance, either overt” Correct? with GAD can lead to a panic attack. However, unlike patients with panic disorder, patients with GAD are concerned primarily about some future event, not about Obsessive-Compulsive Disorder the negative consequences of having a panic attack or Although the differentiation between obsessive-com- the symptoms of anxiety per se. Some patients with pulsive disorder (OCD) and GAD seems obvious be- GAD focus on the physical symptoms of their anxiety, cause of the behavioral rituals that are unique to OCD and this can lead one to think that the preoccupation (Brown et al. 1994), some cases still can be extremely with bodily sensations is a sign of panic disorder. How- difficult to differentiate. This is especially true of pa- ever, there is a distinction between distress about the tients with OCD who do not have overt compulsions presence of bodily sensations (e.g., muscle tension) and (i.e., have only mental rituals). In these cases, a distinc- catastrophic misinterpretations of such sensations (e.g., tion must be made between the obsessions and the wor- my heart racing means I am having a heart attack). An- ries. To do so, it is necessary to assess the focus of con- other distinction is the course of onset of worry com- cern. The nature of obsessions tends to be unrealistic pared with that of panic symptoms. The onset of a panic and often takes an “if-then” form (e.g., “If I don’t cancel attack is sudden, and its peak typically lasts for several the thought that my child will be hurt in a car accident
Psychotherapy for Generalized Anxiety Disorder 257 by imagining him safe at home, then he will be in a car in press, for a review) support the notion that GAD and accident”). In contrast, worry associated with GAD is depression may have a common underlying predisposi- usually focused on future negative events that are poten- tion. In fact, it has been suggested that GAD be moved tially more realistic; and it is more likely to be specified into a category of dysphoric disorders in DSM-V and in a “what if ” fashion, without a consequence being not be included among the anxiety disorders (Watson stated (e.g., “What if I am in a car accident on the high- 2005). way and my children are injured?” or “What if I become ill?”). In research examining the distinction, nonanxious AUTHOR: Above: 1) Please update press status of Hup- subjects reported that worry lasts longer and is more pert reference above. distracting (Wells and Morrison 1994). Worry also usu- ally takes the form of predominantly verbal thoughts as 2) In sentence beginning “According to DSM-IV-TR,” “then opposed to images (Wells and Morrison 1994). Al- GAD” has been substituted for “then it,” to clarify. Please though compulsive behaviors are associated with OCD, confirm this is correct. patients with GAD often engage in reassurance-seek- ing and checking behaviors that can be somewhat ritu- alistic and superstitious (i.e., similar to compulsive be- Review of Treatment havior; Schut et al. 2001). In addition, patients with Outcome Studies GAD may report feeling compelled to act to neutralize their worries (Wells and Morrison 1994; e.g., to call In our previous review of GAD (Huppert and Sander- one’s wife at work to lessen a worry about something son 2002), we reviewed meta-analyses and studies con- happening to her). However, these behaviors are not as ducted between 1987 and 2000. Since 2000, several re- consistent, methodical, or ritualized as compulsive be- views have been written about the treatment of GAD haviors in patients with obsessive-compulsive disorder. (Borkovec and Ruscio 2001; Covin et al. 2008; Gould et al. 2004; Hunot et al. 2007; Mitte 2005; Roemer et al. Mood Disorders 2002; Rygh and Sanderson 2004; Siev and Chambless A differentiation must also be made between GAD and 2007; Westen and Morrison 2001). As in earlier re- mood disorders, especially major depression and dys- views, the efficacy of cognitive-behavioral therapy thymia. According to DSM-IV-TR, if GAD symptoms (CBT) and related strategies (e.g., cognitive restructur- are present only during the course of a depressive epi- ing, relaxation training) has received the most support- sode, then GAD is not diagnosed as a comorbid disor- ive evidence when used to alleviate worry and anxiety. In der. More often than not, anxiety symptoms occur fact, the Task Force of the Division of Clinical Psychol- within the context of depression; thus, GAD is diag- ogy of the American Psychological Association, which nosed as a separate disorder only when the symptoms is involved with identifying empirically supported treat- have occurred at least at some point independent of de- ments, found that the only psychosocial treatment with pression. However, regardless of DSM exclusionary cri- sufficient research support to be labeled “empirically teria, the nature of cognitions associated with each dis- supported treatment” is CBT (Chambless et al. 1998; order can be distinguished: ruminations (common in Woody and Sanderson 1998). Independent reviews of depressive disorders) tend to be negative thought pat- treatments for GAD by the National Institute for Clin- terns about past events, whereas worries (associated ical Excellence in the United Kingdom (McIntosh et al. with GAD) tend to be negative thought patterns about 2004) and by the International Consensus Group on future events. This is consistent with theoretical con- Anxiety and Depression (Ballenger et al. 2001) con- ceptualizations of anxiety and depression, which posit cluded that CBT is equivalent to medication as a first- that depression is a reaction to uncontrollable, inescap- line treatment. Furthermore, Dutch guidelines for able negative events, leading to feelings of hopelessness treatment of anxiety by primary care physicians also rec- and helplessness and deactivation, whereas anxiety is a ommend CBT (van Boeijen et al. 2005). These treat- reaction to uncontrollable negative events that the per- ment recommendations are based on the accumulated son attempts or plans to escape from (for a more de- literature demonstrating the efficacy of CBT for GAD tailed explanation, see Barlow 2002). The high comor- as well as support for the cost-effectiveness of such bidity rates, symptom overlap, and genetic similarities treatments (Heuzenroeder et al. 2004). Although there between GAD and depressive disorders (see Huppert, is some preliminary evidence suggesting short-term
258 TEXTBOOK OF ANXIETY DISORDERS psychodynamic treatments for anxiety disorders may be Newer Studies effective (Crits-Christoph et al. 2005; Ferrero et al. As shown in Table 14–1, during the period 2000–2007, 2007), adequate controlled studies have yet to be con- 17 outcome studies on GAD were published. A few of ducted. Therefore, consistent with the empirical litera- these studies presented follow-up data to previously ture, our review emphasizes CBT. conducted trials; most included CBT and at least one other treatment group, a minimum of a 6-month fol- Previous Reviews low-up assessment, and a variety of outcome measures, Borkovec and Ruscio (2001) conducted a meta-analysis usually a combination of self-report and clinician-rated of treatment outcome studies for GAD. Their primary measures. For Table 14–1, we calculated percentage im- conclusion was that CBT for patients with GAD is provement in anxiety and worry by subtracting post- more efficacious in treating both anxious and depressive treatment averages from pretreatment averages and symptoms than no treatment or nonspecific control then dividing by the pretreatment averages. Data were conditions, and that the combination of cognitive and gathered from information provided in the published behavioral strategies tends to be better than either reports. Self-report and clinician-rated measures were alone. Specifically, they reported large between-group separated, because each type of information can be sub- effect sizes for acute CBT when compared with no stantially different (i.e., a clinician may see improve- treatment, medium effect sizes when compared with ment when a patient does not, or vice versa). Whether placebo or alternative therapies, and small effect sizes authors noted improvement, no change, or relapse dur- when compared with cognitive or behavioral therapy ing follow-up periods is noted next in the table. Finally, alone. Nonspecific treatments (e.g., supportive psycho- the rate of dropout is presented in the last column. Note therapy) were reported to have large within-group effect that many percentages of improvement were calculated sizes, but smaller than CBT. Long-term follow-up sug- by using treatment-completer analyses; these results gested smaller, but sustained, advantages of CBT over could have been substantially different if intent-to-treat other treatments. Similar conclusions about the efficacy analyses had been used. We do not review each study of CBT for GAD were reported by Gould et al. (2004). here because many of them are included in the previous However, in their review, Hunot et al. (2007) concluded discussion of meta-analytic reviews. that it is difficult to determine whether CBT is substan- tially more effective than supportive therapy. A meta- AUTHOR: In sentence above beginning “Note that many analysis by Mitte (2005) in which CBT was compared percentages,” please check edited version to ensure it to medications revealed that overall, CBT was superior keeps the intended meaning. to no treatment or placebo control conditions and was similar in effectiveness to medications. However, fur- ther analyses suggested that medications for GAD may Table 14–1 is currently at the end of the chapter. It will be be somewhat more effective than CBT, even though positioned about here at a later phase of production. CBT may be more tolerable than medications (based on lower dropout rates). In her conclusions, Mitte stated The 17 studies can be divided into numerous catego- that it is clear CBT for GAD has specific treatment ef- ries: studies examining the efficacy of CBT versus wait- fects beyond common factors. Most reviews conclude list conditions, dismantling designs that examined that approximately 50% of patients receiving CBT are relaxation versus cognitive therapy (and/or their combi- categorized as responders. nation), studies attempting to improve CBT outcomes by adding other techniques, and studies examining psy- AUTHOR: Above, “Long-term follow-up suggested...”: chodynamic therapies. Some of these studies also pro- Please clarify how this report of a follow-up finding relates vided analyses to determine predictors of treatment to the 2001 meta-analysis of many studies by Borkovec and Ruscio, and provide a reference and citation if neces- outcome, which will be discussed later. Studies varied in sary. Thanks. terms of the length of treatment sessions employed and in the number of treatment sessions included. As in our review of studies that were published during the 1990s (Huppert and Sanderson 2002), percentage of improve- ment was rated consistently greater by “blind” clinicians
Psychotherapy for Generalized Anxiety Disorder 259 than by patients’ self-reports. According to indepen- cused techniques, rather than just an increase in the dent evaluators, CBT yielded from 30% to 66% im- amount of CBT. Indeed, Newman et al. (2008) have re- provement in anxiety, and self-report measures yielded cently completed a trial of CBT alone compared with an between 11% and 61% improvement. With regard to integrated CBT plus interpersonal and emotion-fo- follow-up, all but one study revealed no significant cused therapy. Preliminary results suggest that CBT changes (either deterioration or improvement) from alone was as effective as the integrated treatment at posttreatment to follow-up. However, one study did posttreatment and at 1-year follow-up. However, for a show statistically significant continued improvement subgroup of patients, advantages of the integrated treat- after acute treatment (i.e., improvement from posttreat- ment in anxiety symptom reduction at 2-year follow-up ment to follow-up). With regard to comparisons with emerged (Newman et al. 2008). other treatments, overall, CBT was seen as significantly At present, perhaps the area receiving the greatest more effective than the waitlist control condition, and amount of attention within the CBT field is the incor- results for those who received CBT after being in the poration of mindfulness meditation and acceptance-based waitlist group showed they improved similarly to those techniques into, or instead of, standard CBT approaches. who initially received CBT (Bowman et al. 1997; These techniques have been examined in the treatment Ladouceur et al. 2000). Dismantling studies found that of GAD as well. Unfortunately, preliminary results cognitive therapy, relaxation, and their combination from initial trials in which the outcomes are compared yielded similar effect sizes (see also Siev and Chambless with other CBT trials have not supported the notion 2007). that these strategies provide an additional benefit. The inclusion of mindfulness and acceptance-based tech- AUTHOR: Above, in last sentence, “dismantling studies”: niques (Evans et al. 2008; Roemer and Orsillo 2007) Please clarify this phrase (or define this term). does not appear to enhance the efficacy of CBT for GAD (see Table 14–1). Two therapeutic strategies that appear to be promis- To date, attempts to improve outcome by adding or ing additions to CBT are the addition of well-being ex- modifying techniques have yielded variable results, with ercises (i.e., focusing on improving quality of life and some findings showing more promise than others. positive aspects of one’s life; cf. Fava et al. 2005) and Durham et al. (1994, 2004) have examined longer- ver- meta-cognitive therapy (i.e., focusing specifically on sus shorter-duration CBT, with mixed findings. positive and negative beliefs about worry, thought con- Durham et al. (1994) suggested that 16 sessions of CBT trol strategies, and other techniques; Wells and King may be more effective than 8 sessions. However, in a 2006). Table 14–1 provides more details of these and second study in which patients were a priori categorized other studies modifying CBT. into those likely to have good versus poor outcome, Three studies have examined the efficacy of psycho- Durham et al. (2004) found that providing more CBT dynamic treatments for GAD. Although two of these (20 vs. 10 sessions) to individuals predicted to have poor studies are predominantly nonrandomized trials, the outcome did not improve outcomes. In contrast, pro- fact that they include psychodynamic treatment, which viding short-duration CBT (6 sessions) to individuals is a commonly utilized approach in clinical practice, predicted to have good outcomes worked quite well merits their extensive consideration. Therefore, more (equivalent to those receiving more sessions, in the details about these studies are described, although this group predicted to have poor outcomes), and improve- should not be seen as an endorsement of these tech- ment continued at follow-up (see Table 14–1). Bork- niques over CBT approaches that have been studied ovec et al. (2002) modified typical CBT by including 2- more extensively. Each study used a different school of hour sessions for all conditions. Although they found psychodynamic thought (psychoanalytic/classical somewhat larger effect-sizes compared with other stud- Freudian, neo-Freudian interpersonal, Adlerian). ies using this treatment in the short run (at posttreat- Durham et al. (1994, 1999, 2003) were the only inves- ment), the results were not substantially better than pre- tigators to examine both cognitive and psychodynamic vious findings at follow-up. As a result of this study and therapies for GAD. Crits-Christoph et al. (1996) con- their clinical experiences, Borkovec et al. (2002) sug- ducted an open trial examining the effects of short-term gested the need to examine alternative strategies to psychodynamic therapy for GAD, for which 1-year fol- CBT, such as addition of interpersonal and emotion-fo- low-up data are available (Crits-Christoph et al. 2004).
260 TEXTBOOK OF ANXIETY DISORDERS The group also published a randomized trial, suggesting that nondirective, supportive therapy was equally as ef- AUTHOR: In above sentence beginning “Results of this fective as their psychodynamic approach (Crits-Chris- study indicated...”: Change OK? toph et al. 2005). They presented their data in a com- bined sample. In addition, Ferrero et al. (2007) reported This study had several strengths. First, the authors on a trial of short-term Adlerian psychodynamic ther- measured patients’ expectancies of recovery through apy. Each of the treatments yielded improvements in therapy, which showed that patients in both CBT and symptoms, although the degree of improvement dif- relaxation training had greater expectations of improve- fered. ment than did those in the psychoanalytic groups after the third treatment session. In addition, they used well- AUTHOR: Please review edits to sentence above begin- trained therapists who were strong believers in their re- ning “Therefore, more details.” OK? spective theoretical perspectives, thus eliminating ex- perimental bias (allegiance effects) for any one treat- ment. However, the study had several weaknesses as Durham et al. (1994) compared cognitive therapy well. The researchers did not conduct adherence or (Beck et al. 1985) to anxiety management (a behavioral competency ratings to ensure that the therapists in fact technique) and to psychoanalytic therapy. A total of 110 provided the said treatment components. In addition, patients with GAD were divided into five groups: 1) few therapists were used in the study and, as a result, it brief CBT (average of 9 sessions), 2) extended CBT was possible that some of the treatment differences (average of 14 sessions), 3) brief analytic therapy (aver- could have been due to therapist differences. age of 8 sessions), 4) extended analytic therapy (average Crits-Christoph et al. (1996, 2004, 2005) conducted of 16 sessions), and 5) anxiety management training an open clinical trial and a small randomized trial of a (average of 8 sessions). Results of this study indicated short-term psychodynamically oriented treatment for that patients who received any form of CBT improved GAD called supportive-expressive psychodynamic most and those who received psychoanalytic psycho- therapy (SEP). The authors used treatment manuals, therapy improved least, with the group receiving anxiety adherence ratings, and therapists carefully trained in a management showing levels of improvement some- psychodynamic treatment to target problems specifi- where in between. Patients who received psychoanalytic cally thought to arise in GAD. SEP is grounded in psy- treatment deteriorated on three measures (although not chodynamic theory, positing that anxiety is related to significantly), whereas patients in the CBT groups im- conflictual interpersonal attachment patterns and in- proved on all measures at posttreatment and 6-month complete processing of past traumatic events. The treat- follow-up, and the anxiety management group main- ment focused on conflicts in relationships through ex- tained gains. Follow-up data revealed that patients con- amining the interpersonal desires of the patient tinued to improve after CBT or anxiety management (wishes), reactions of others to these desires, and conse- was terminated. Follow-up data at 1 year and 8–10 years quences of these reactions. Relationships explored in- have been published (Durham et al. 1999, 2003). At cluded current and past relationships, as well as the 1 year, CBT continued to show superiority to psycho- therapeutic relationship. In SEP, the proposed mecha- analytic therapy in terms of symptom reduction, re- nism of change is through working with the patient on sponse rates, and overall functioning, and there were exploring alternative methods of coping with feelings some advantages found for more intensive CBT over and interpersonal conflicts. SEP orients the therapist to fewer sessions. Anxiety management continued to be a deal with specific GAD-oriented wishes, mechanisms bit less effective than CBT and more effective than psy- of defense, and resistances. In addition, the influence of choanalytic therapy. At the 8–10-year follow-up, many termination on the patient is explored in depth. differences between CBT and psychoanalytic treatment A total of 61 patients with GAD (diagnosed by on anxiety and response measures had disappeared, structured interview) were treated by therapists trained though functioning and global symptom measures con- in SEP (Crits-Christoph et al. 2005). Posttreatment tinued to indicate CBT was superior. It is interesting to measures indicated significant improvement in all areas. note that a greater number of patients who received psy- There was less change in specific areas of interpersonal choanalytic therapy sought further treatment between functioning (dominant and overly nurturing styles) the posttreatment and follow-up assessments. than expected. Overall, effect sizes were similar to those
Psychotherapy for Generalized Anxiety Disorder 261 calculated for CBT and nondirective psychotherapy. A pact of additional diagnoses on treatment outcome. Al- subset of these patients was part of an unpublished ran- though many of the treatment studies described above domized trail comparing SEP with nondirective sup- have included patients with a variety of comorbid diag- portive therapy (see Borkovec and Abel 1991, in which noses, only four published studies have specifically ex- CBT was superior to the same treatment). No differ- amined the effect of comorbid disorders on the treat- ences in outcome were found on continuous measures. ment of GAD. Borkovec et al. (1995) found that However, the quality of the response among patients re- comorbid anxiety disorders tended to remit when treat- ceiving SEP was better than among those receiving the ment focused on GAD. Of 55 patients with a principal nondirective therapy (i.e., more were considered to be diagnosis of GAD, 23 (41.8%) were rated as having at remitters), and the variability of response was less. least one clinically significant comorbid Axis I diagnosis Thus, preliminary data suggest that this new, innovative (patients with major depression had been ruled out of psychodynamic therapy may be effective for patients the study, thus decreasing the overall rate of comorbid- with GAD, and is certainly worthy of further investiga- ity). At a 12-month follow-up, only two patients re- tion. tained a clinically significant comorbid diagnosis, sug- gesting that in most cases, comorbid anxiety disorders AUTHOR: Please provide a full reference to correspond to may not need to be addressed directly. This may be above citation of Borkovec and Abel 1991. largely a result of the fact that the treatment for GAD may be useful in reducing other anxiety symptoms as well. For example, learning cognitive restructuring as Another psychodynamic approach, Adlerian psy- applied to worry in GAD may ultimately be generalized chodynamic therapy (APT), was examined in a clinical by the patient and used for coping with other anxiety trial by Ferrero et al. (2007). Patients with GAD were symptoms. Ladouceur et al. (2000) reported that their assigned to either APT, medication management, or sample of 26 patients included individuals with multiple the combination, based on clinical judgment of what comorbid diagnoses—most commonly, specific phobia was best for the patient by the treating psychiatrist. Re- and social phobia. At pretreatment, patients had an av- sults suggested that all three conditions were effective, erage of 1.6 additional diagnoses, whereas at posttreat- although the percentage of improvement was somewhat ment and follow-up, they had significantly fewer (an av- lower than in CBT treatment trials. Given the lack of erage of 0.4) additional diagnoses. random assignment, it is difficult to make firm conclu- Sanderson et al. (1994) examined the influence of sions from this study. However, it appeared that APT personality disorders on outcome in an open trial and was quite effective in reducing anxiety and depression found that CBT treatment effects were equivalent for and improving quality of life. In addition, there was no GAD patients with and without personality disorders. difference in outcome in the APT condition for those However, patients with personality disorders were more with Axis II disorders and those without, whereas for likely to drop out of treatment. A total of 32 patients medication treatment, there appeared to be poorer re- with diagnoses of GAD were separated into two groups, sponse among patients with Axis II disorders. Overall, based on whether or not they had a concurrent person- the results complement the findings of Crits-Christoph ality disorder. Of the 32 patients, 16 were diagnosed et al. (2005), demonstrating that short-term dynamic with a personality disorder and 16 without. Of the 10 therapy focused on interpersonal issues can be thera- dropouts (those not receiving what was defined as a peutic for individuals with GAD. Clearly, more re- minimal dose of treatment), 7 were given a diagnosis of search is needed on these psychodynamic treatments, a personality disorder at the pretreatment evaluation. especially controlled trials, as well as investigation into Effect sizes of treatment completers in both groups the mechanism of action of psychodynamic treatment were similar to those mentioned by Borkovec and Rus- and whether or not it differs from that of CBT (Ablon cio (2001). In light of these data, it appears that atten- and Jones 2002). tion should be paid to issues related to dropout in pa- Effect of Comorbidity on Outcome of tients with personality disorders (e.g., difficulties Generalized Anxiety Disorder forming therapeutic relationships, which is a consistent theme in a subgroup of GAD patients, as noted above). Given the high rate of comorbidity in GAD (Sanderson Analogous to the finding in the Borkovec et al. and Barlow 1990), it is important to determine the im- (1995) study, a number of studies have focused on
262 TEXTBOOK OF ANXIETY DISORDERS changes in comorbidity rates in treated patients with Special Populations principal diagnoses of panic disorder. Brown et al. (1995) reported that GAD remitted when the focus of Older Adults treatment was on the principal diagnosis of panic disor- Although controversy exists as to whether or not the der in patients with a comorbid diagnosis of GAD. Of typical onset of GAD tends to be earlier versus later in 126 patients with panic disorder, 32.5% received an ad- life (Barlow 2002), it is safe to say that a significant per- ditional diagnosis of GAD. Comorbidity did not appear centage of older adults (i.e., >age 60 years), perhaps as to influence completer status, but did appear to influ- high as 7% of the population, suffer from GAD (Flint ence initial severity of panic (i.e., those with a comorbid 1994). Given that the vast majority of treatment trials disorder had more severe panic disorder). Of the 57 pa- on GAD examine considerably younger subjects (in tients available for follow-up analyses, 26.3% were given fact, some exclude individuals over age 65), it cannot be diagnoses of GAD at pretreatment, whereas only 7.0% assumed that the effectiveness of treatment found in were given such diagnoses at posttreatment, 8.8% at 3- those trials applies to older adults. Thus, a body of re- month follow-up, and 8.8% at 24-month follow-up. search has emerged examining the efficacy of CBT, as Thus, 11 of 15 (73.3%) patients did not meet criteria for described above, for GAD in older adults (e.g., Stanley a clinical diagnosis of GAD at posttreatment, and gains et al. 1996, 2003___; Wetherell et al. 2003). Clearly, the were maintained throughout follow-up assessments. treatment with the most consistent support for late-life Similar findings have been found by Tsao and col- GAD is CBT (Ayers et al. 2007), with approximately leagues in three studies (2005). Once again, considering half of patients achieving a significant improvement that the strategies used in CBT for panic disorder are (Wetherell et al. 2005). Although these results are similar to those used for GAD, it is not surprising that promising, it is important to note that, overall, re- the treatment would generalize to other anxiety symp- sponder rates in studies of GAD in older adults have toms as well (Sanderson and McGinn 1997). been somewhat lower than those reported in the litera- ture on younger adults (Stanley et al. 2003___). In light Predictors of Outcome of this finding, a study by Mohlman et al. (2003) is par- Durham and colleagues (2004) have been the most sys- ticularly interesting. In a preliminary, uncontrolled tematic in examining predictors of treatment outcome. study, they tested an “enhanced version” of CBT that in- In two studies, they found that predictors of poor out- cluded learning and memory aids designed to make the come include greater initial severity, low socioeconomic therapy more effective for elderly patients (e.g., home- status, comorbidity, history of previous treatment, and work reminder and troubleshooting calls) and found it relationship difficulties. The last is consistent with to be superior to standard CBT. Investigating this mod- studies by Borkovec et al. (2002) and Zinbarg et al. ification in controlled trials is certainly warranted, and (2007), both of which found pretreatment interpersonal may eliminate the gap between response rates in style or hostile communication patterns with partners to younger and older adults suffering from GAD. be predictive of treatment outcome. In addition, Durham et al. (2004) found that the therapeutic alliance AUTHOR: Please see reference list and identify the two was a good predictor of acute outcome but a much less Stanley et al. 2003 citations above as 2003a or 2003b. significant predictor of long-term outcome. Children AUTHOR: In first sentence above, please provide a con- text for “have been the most systematic” (among all Although there are no studies examining the efficacy of researchers of GAD? or among all whose studies are CBT in an exclusive sample of children diagnosed with reviewed in this chapter?), or change wording (e.g., “... GAD, several trials have evaluated CBT on mixed sam- have been highly systematic...”) ples, often including children with GAD, overanxious disorders, and social anxiety disorder. For example, a large study by Kendall et al. (2004) included 94 children who had an anxiety disorder—55 of whom were diag- nosed with GAD. Data revealed significant improve- ment in anxiety symptoms from pretreatment to post- treatment. In a thorough review of the literature on
Psychotherapy for Generalized Anxiety Disorder 263 CBT for childhood anxiety disorders, Chorpita and Many patients experience great relief in knowing that Southam-Gerow (2006) concluded that CBT has “very their experiences are not uncommon, that a consider- strong empirical support” for childhood GAD. It is able amount of scientific knowledge exists about the eti- worth noting that although the treatment closely re- ology and phenomenology of GAD, and that effective sembles the intervention package utilized for adults treatments designed specifically for their difficulties are (i.e., it includes cognitive and behavioral components), available. Finally, providing education about GAD is a the child intervention by Kendall (1990), labeled the way to review the treatment rationale (i.e., what the Coping Cat Program, has been modified to be more purpose of each treatment strategy is) and thus may fa- child-friendly. cilitate treatment compliance. We recommend that psychoeducation be provided CBT Techniques for Generalized first in a written form (e.g., via a Web site on GAD such as the one available through the National Institute of Anxiety Disorder Mental Health (http://www.nimh.nih.gov/health/topics/ As should be clear by now, CBT is the only psychother- generalized-anxiety-disorder-gad/index.shtml) and then apeutic approach with strong empirical support from followed up in session. During the session, questions are controlled research studies. Although there may be answered and the information is reviewed in a manner some subtle differences in treatment packages employed that makes the information personally relevant to the within these studies, for the most part, there are several patient. common “essential” elements contained in almost every CBT manual for GAD. (For detailed descriptions of Self-Monitoring these techniques, see: Rygh and Sanderson 2004; Zin- Self-monitoring is one of the most basic yet essential barg et al. 2006.) These methods include psychoeduca- parts of CBT. Monitoring is used as both an assessment tion, self-monitoring, cognitive restructuring, relax- procedure (to identify the context and content of worry) ation, worry exposure, worry behavior control, and and a treatment strategy. (Becoming aware of patterns problem solving. Of course, these techniques should be and focusing on worry and anxiety may lead to reduc- delivered in the context of a good psychotherapeutic at- tion in worry and anxiety.) The basic concept of moni- mosphere that includes all of the nonspecific effects of toring is that each time the patient feels worried or anx- therapy (e.g., a good therapeutic relationship, positive ious, he or she should record when and where the expectancy, warmth). Each technique is briefly de- anxiety began and the intensity of the experience, in- scribed below. cluding symptoms that were present. The patient can monitor his or her experience on a full sheet of paper Psychoeducation that describes the entire week or record one situation or As in most cognitive-behavioral treatments, psychoed- day at a time. The amount of information gathered may ucation about GAD is an important aspect of therapy. vary with each patient, according to each individual’s Several rationales exist for starting treatment with edu- abilities and needs. It should be noted that avoidance of cation about anxiety and worry. First, we believe that monitoring is seen as detrimental to treatment, because knowledge is an important factor in change. Many pa- of the likelihood that the patient is avoiding anxiety. tients who have come in for treatment have never been Thus, we prefer to simplify and problem-solve to attain told their diagnosis and frequently have misconceptions compliance rather than eliminate the monitoring alto- about their disorder (e.g., that anxiety will lead to psy- gether. chosis) and misunderstandings about common re- To enhance compliance, the therapist should inform sponses (e.g., physiological, emotional) to worry and the patient of the reasoning behind the monitoring: to stress (e.g., that all worry is bad or that increased heart help elicit specific patterns that occur and lead to worry rate means that you are more likely to have a heart at- episodes, to obtain a good estimate of current symp- tack). In addition, some patients want a greater under- toms, to be able to notice effects of treatment on symp- standing of why they are anxious and what they can do toms, and to further examine worry (e.g., cognitions, about it. So, the first step in CBT treatment is educating behaviors). The basic aspects of worry monitoring are patients about the biopsychosocial model of anxiety date, time began, time ended, place, event (trigger), av- (Rygh and Sanderson 2004; Borkovec et al. 2004). erage anxiety (from 1 [minimal] to 8 [extremely dis- tressing]), peak anxiety (1–8), average depression (1–8),
264 TEXTBOOK OF ANXIETY DISORDERS and topics of worry. Once cognitive restructuring is in- the patient to uncover his or her thoughts during anxi- troduced, monitoring the specific thought process in- ety-provoking situations), role-playing (if worry oc- volving worries is added. curred during a social interaction, playing the role of the friend and replaying the event in the session), and im- Cognitive Therapy: Restructuring the Worry agery (trying to visualize a worry-provoking event to ac- As stated earlier, worry is a predominantly cognitive cess thoughts and fears). Increases in levels of anxiety process, thereby making cognition an important aspect either in or outside of the session are opportune times to to address. Cognitive therapy is an effective strategy for monitor “hot” cognitions. This often needs to be mod- this purpose. Patients with anxiety disorders, and with eled by filling out a thought record and helping the pa- GAD in particular, overestimate the likelihood of neg- tient elicit thoughts (e.g., “I won’t be able to do the ative events and underestimate their ability to cope with homework right”) in session before patients can accu- difficult situations (A.T. Beck et al. 1985). These “cog- rately monitor their thoughts for homework. It is often nitive distortions” can play a major role in the vicious helpful to warn patients that monitoring thoughts can cycle of anxiety, and they accentuate the patient’s feel- provoke anxiety because one is focusing on anxious cog- ings of danger and threat. Thus, cognitive therapy tar- nitions. It should be explained that exposure to such gets the faulty appraisal system and attempts to guide thoughts, while uncomfortable, is necessary for change. the patient toward more realistic, logical thinking. Once thoughts have been monitored sufficiently to The idea of cognition and its influence on anxiety are determine frequency and themes, categories of distorted reviewed with the patient in the introduction to therapy thinking are introduced. Several cognitive distortions and the psychoeducation discussion. Threaded have been identified as common in patients with GAD, throughout the biopsychosocial model is the theme that the three most common being probability overestima- cognition plays a major role in eliciting and perpetuat- tion, catastrophizing, and all-or-none (black-and- ing the cycle of anxiety. Cognitive restructuring is intro- white) thinking (A. T. Beck et al. 1985; Brown et al. duced in detail by discussing the concepts of automatic 1993). thoughts, anxious predictions, and the maintenance of Frequently, many distortions exist within one state- anxiety through unchallenged/unchecked negative pre- ment. In our clinical experience, it can be very helpful to dictions about the future. address all of the distortions in each statement. This will help the patient have a fully loaded armamentarium AUTHOR: Above, note change from “Threaded . . . is the against anxious thoughts. A patient may remain anxious fact that . . .”: (One doesn’t usually think of a “fact” as after challenging a thought-focus on a single type of “threaded.”) Change OK? distortion because he or she is still apprehensive about another distortion. Thus, we believe that the most ef- fective strategy is to thoroughly process all cognitive Automatic thoughts are described as learned responses distortions. For example, a patient presents with a worry to cues that can occur so quickly that they may be out- statement that he is not going to be able to pay the rent side of one’s awareness. However, these cognitions can on time because he thinks that his paycheck will come in create, maintain, and escalate anxiety if their content the mail late. We would have the patient evaluate the contains information with a danger-related theme. probability that he will not pay the rent, based on past Thus, the patient is taught to observe his or her own experiences of receiving his paycheck, evaluate the con- thoughts at the moment of anxiety (or immediately af- sequences of his paying the rent late, and evaluate his ter), to assess what cues may have brought on the feel- belief that if he is 1-day late with the rent, it is as if he ing, and to elaborate on what thoughts were going will never pay it. Thus, the one worry may contain all through his or her mind. The goal is to bring the three categories of distortions. Challenging in this fash- thoughts into awareness. Initially, the thoughts are not ion focuses on automatic thoughts. This may be suffi- immediately challenged but collected as data to deter- cient for some patients, but for others it may be neces- mine common thoughts that occur during worry. In ad- sary to examine core beliefs (i.e., consistent thought dition to self-monitoring during anxiety episodes, anx- patterns about oneself, the environment, or the future; ious cognitions are accessed within the therapy session J.S. Beck 1995). through Socratic questioning (asking questions to lead
Psychotherapy for Generalized Anxiety Disorder 265 Relaxation that strategy. At times, a combination of relaxation Relaxation exercises are an important component of techniques can also be encouraged, depending on the most CBT-oriented treatments for GAD. The function needs of the patient. Accordingly, yoga, transcendental of these exercises is to reduce the physiological corre- or other types of meditation, and tai chi are all accept- lates of worry and anxiety by lowering the patient’s able, especially if the patient is already engaged in such overall arousal level. Relaxation reduces arousal, but it activities and/or if progressive muscle relaxation does may play other roles as well. First, it may help broaden not appear effective. the focus of one’s attention; anxiety tends to narrow at- There are several caveats to be noted about conduct- tentional focus (Barlow et al. 1996). As a result of its ing progressive muscle relaxation. First, the goal is to anxiety-reducing property, relaxation may widen the have the patient feel relaxed. Although similar proce- scope of attention and thereby increase the patient’s dures are used to help patients with insomnia, the goal ability to consider alternatives in an anxiety-provoking here is not to have the person fall asleep. Second, this situation. In addition, relaxation may serve as a distrac- procedure is similar to those used in initiating a hyp- tion. Distraction is not effective as a sole method, be- notic trance; because of this, patients may react to the cause by constantly avoiding anxious cognitions, the procedure with anxiety, fearing a “loss of control.” It is patient is subtly supporting the belief that his or her important to explain to the patient the difference be- thoughts are threatening and/or harmful. However, dis- tween hypnosis and relaxation, as used in CBT for traction can be an effective tool when the GAD patient GAD, is that in progressive muscle relaxation the focus is “stuck” in a worry pattern and needs to break the per- is on awareness of bodily sensations. Hypnosis has the severating thoughts. Finally, contrary to the concepts goal of distraction to the point of reaching a trance state. described above and to conventional wisdom, which as- This would be counterproductive in treating GAD be- sumes that relaxation is solely a coping strategy, relax- cause, as discussed in this section, these patients are al- ation may at times facilitate the activation of anxious ready distracted from aversive states through worry. Our thoughts that are otherwise not being processed (Bork- goal is facilitated exposure to worry-provoking stimuli, ovec and Whisman 1996), thereby assisting in exposure not avoidance. to the anxious thoughts. This may explain why some Worry Exposure patients describe becoming more anxious when initially engaging in relaxation exercises. Specifically, worrying As noted above, the perpetuation of worry in GAD pa- prevents the processing of other, more fearful informa- tients may be caused by incomplete processing of the tion (see Borkovec and Hu 1990), and relaxation helps worry, which may be a result of avoiding focusing on the reduce this “protective” worry and thus may ultimately worry itself. Instead of focusing on a worry that will in- aid in exposure to fearful thoughts, ideas, or images that crease anxiety in the short run, patients attempt to avoid were not fully processed through or evoked by worrying. fully processing the worry through various behaviors (discussed in the next section), as well as through con- stant shifting of worries. For this reason, Brown et al. AUTHOR: 1) Please review edited last sentence above to (1993) described a technique in which patients pur- ensure that it keeps the intended meaning. OK as edited? posely expose themselves to both worry and images as- 2) Please provide a full reference to correspond to the sociated with the worry for an extended period. The above citation of Barlow et al. 1996. concept is to have the patient activate the worst possible outcome in order to process it and habituate to the anx- Whether for any of the reasons cited above or for iety associated with it. Habituation of the anxiety is fa- other reasons not discussed here, relaxation clearly helps cilitated through cognitive challenging after the patient patients with GAD. Most recent methods of teaching focuses on the image for 20–30 minutes. Similar proce- relaxation have adapted a flexible concept rather than dures (called cognitive exposure) are used to facilitate in- insisting on any particular approach. Thus, although tolerance of uncertainty in the treatment developed by progressive muscle relaxation techniques are empha- Dugas et al. (2003). Borkovec et al. (1983) developed a sized for most patients and have the most empirical sup- similar technique referred to as stimulus control. In this port, if a patient prefers another method and is able to approach, patients are asked to postpone worrying use it effectively, then we recommend continued use of when it begins to happen, make a list of the worries that occur, and then set aside an hour in the evening to focus
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