PSYCHOLOGY, PSYCHIATRY, IMAGING & BRAIN NEUROSCIENCE SECTION
←
→
Page content transcription
If your browser does not render page correctly, please read the page content below
Pain Medicine 2018; 19: 50–59 doi: 10.1093/pm/pnx005 PSYCHOLOGY, PSYCHIATRY, IMAGING & BRAIN NEUROSCIENCE SECTION Original Research Article The Association of Post-traumatic and Downloaded from https://academic.oup.com/painmedicine/article-abstract/19/1/50/3062387 by guest on 11 February 2020 Postmigration Stress with Pain and Other Somatic Symptoms: An Explorative Analysis in Traumatized Refugees and Asylum Seekers Naser Morina, PhD,* Alexa Kuenburg, MD,* Ulrich Methods. One hundred thirty-four treatment-seek- Schnyder, MD,* Richard A. Bryant, PhD,† Angela ing traumatized refugees (78% male, mean age 5 42 Nickerson, PhD,† and Matthis Schick, MD* years) were assessed regarding lifetime traumatic experiences, symptoms of post-traumatic stress, overall pain and somatic symptoms, and postmigra- *Department of Psychiatry and Psychotherapy, tion living difficulties. University Hospital Zurich, University of Zurich, Zurich, Switzerland; †School of Psychology, University of New Results. An exploratory factor analysis of the 12 so- South Wales, Sydney, Australia matic symptoms revealed two distinct factors: so- matic symptoms related to bodily dysfunction Correspondence to: Naser Morina, PhD, Department (“weakness”) and somatic symptoms related to in- of Psychiatry and Psychotherapy, University Hospital, creased sympathetic activity (“arousal”). DSM-5 University of Zurich, Culmannstrasse 8, 8091 Zurich, PTSD Criteria D “alterations in cognitions and mood” Switzerland. Tel: þ41-44-255-52-80; Fax: þ41-44-255- and E “alterations in arousal and reactivity” were pri- 44-08; E-mail naser.morina@usz.ch. marily related to “weakness,” while PTSD Criterion E “alterations in arousal and reactivity” and postmigra- Funding sources: This study was partly supported by tion living difficulties were associated with “arousal.” the Parrotia Foundation, the Swiss Federal Office for Overall pain was associated primarily with living diffi- Migration (3a-12-0495), and the Swiss Federal Office culties and PTSD Criterion D and Criterion E. for Health (12.005187). AN was supported by a National Health and Medical Research Council Conclusions. Results indicate that somatic symptoms Clinical Early Career Fellowship (1037091). are of considerable concern among traumatized refu- gees and that different patterns of somatic symptoms Conflicts of interest: The authors disclose no conflicts are associated with different clusters of PTSD symp- of interest. toms. The findings contribute to the better understand- ing of the symptom presentation of traumatized people who are experiencing somatization and poten- Abstract tially inform treatment directions and highlight the im- portance of screening for PTSD in refugees presenting Objective. Post-traumatic stress disorder (PTSD) with pain and somatic symptoms. and somatic symptoms, such as pain, are fre- Key Words. Post-traumatic Stress Disorder; quently seen in refugees. Their relationship is Trauma; Pain; Somatic Symptoms; Postmigration poorly understood, and the treatment of these co- Living Difficulties; Refugee morbid conditions can be very challenging. The cur- rent cross-sectional study examined pain and other somatic symptoms and their relationship with Introduction trauma history, PTSD symptom clusters, and cur- rent living difficulties among treatment-seeking In the current international context, the number of refu- refugees. gees and internally displaced people worldwide is C 2017 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com V 50
Trauma and Somatic Symptoms in Traumatized Refugees increasing dramatically and recently exceeded 65 million family, which may increase the risk of developing psy- [1]. By definition, refugees have experienced persecution chological symptoms [29,30]. Despite numerous studies and are thus often subject to repeated and severe trau- attesting to the link between trauma exposure, matic experiences, including life-threatening situations, postmigration stressors, and psychological disorders in torture, and multiple bereavement [2]. Accordingly, high refugees, there is little evidence on how somatic symp- rates of trauma-related psychological disorders, includ- toms in traumatized refugees can be explained and how ing post-traumatic stress disorder (PTSD), depression, they interfere with other determinants of refugee mental and anxiety, have been reported in refugees [3–5]. health. There is little research that has demonstrated that postmigration stress is associated with somatization PTSD is often associated with comorbid conditions, and and somatoform disorders in refugee and immigrant Downloaded from https://academic.oup.com/painmedicine/article-abstract/19/1/50/3062387 by guest on 11 February 2020 physical complaints have been found to be among the groups [31–33]. Literature has shown that patients with most frequently reported symptoms in individuals with somatic symptoms have excessively higher rates of PTSD [6]. Comorbid chronic pain—a prominent mani- health care utilization and in addition such patients may festation of somatic symptoms—has been reported in contribute to increasing cost of health care services 34% to 80% of PTSD patients [7–9], and the frequent [34]. A better understanding is needed to provide effec- co-occurrence of PTSD with unexplained somatic tive treatment for this highly vulnerable population. symptoms and medical conditions is well documented [10,11,12]. Particularly high comorbidity rates of PTSD This exploratory study examines the nature of pain and and somatic symptoms have been demonstrated in somatic symptoms, as well as their interaction with samples of refugees [13,14] and torture survivors [15]. PTSD and postmigration living difficulties (PMLDs), in a Furthermore, somatization is considered a vital part of sample of treatment-seeking refugees. On the premise post-traumatic symptomatology in relation to complex that pain is associated with elevated stress, we hypoth- trauma [16]. esized 1) a positive association of PTSD symptoms, pain, and somatic symptoms; and 2) due to the explor- While there is solid evidence with regard to the frequent ative character of this study, no hypothesis was made co-occurrence of trauma-related mental and somatic regarding the exact nature of the association between health problems, the nature of this relationship is still PTSD symptoms and level of PMLDs. poorly understood. Psychological, behavioral, and bio- logical factors, as well as the complex interactions be- Methods tween these factors, serve as possible mechanisms through which PTSD may be associated with physical Participants health [10,17]: Somatic presentations may occur in PTSD patients as a result of a number of mechanisms, These data were collected between May 2012 and including 1) trauma-independent somatic disorders; 2) August 2013. Participants were refugees or asylum traumatic injuries and tissue damage sustained in the seekers who had survived war and/or torture and came course of the initial traumatic event; 3) somatic condi- from a variety of refugee backgrounds. At the time of tions related to the increased allostatic load or to unfa- the study, they were receiving psychological treatment vorable health habits associated with PTSD; 4) for trauma-related health complaints at the outpatient autonomic, neuroendocrine, and immunologic dysregu- units for victims of torture and war in either Zurich or lation resulting from PTSD; 5) genetic and epigenetic Bern, Switzerland. Inclusion criteria were written in- predispositions; 6) somatoform disorders, particularly formed consent, being 18 years or older, and speaking dissociative or conversion disorders associated with ele- one of the study languages, that is, German, English, vated stress levels; 7) somatic intrusions that function Turkish, Arabic, Farsi, or Tamil. Patients were excluded as a form of re-experiencing of the trauma; or 8) alexi- if they were unable to fill in self-report questionnaires, if thymia or culture-dependent expression of psychological they were pregnant, if they had a severely impaired dis- distress [18–22]. So far, several theoretical models, tress tolerance (for example, severe dissociative symp- such as the mutual maintenance model [23], the shared toms), or if they were currently suffering from psychosis vulnerability model [24], and the fear avoidance model or were acutely suicidal or a threat to others. [25], have been suggested to explain the mechanisms of the co-occurrence of pain and PTSD. Based on the inclusion criteria, 152 patients were invited to participate in the study and 137 patients (90.1%) Refugee mental health is becoming an increasingly im- agreed to participate. After three participants failed to portant public health concern in hosting societies attend the assessment, 134 participants were included [3,26,27]. While evidence-based therapies for PTSD in in the final sample. refugees do exist [28], there are no empirically sup- ported treatments for trauma-related somatic symp- Measures toms. In addition, over and above the adverse psychological and physical effects of trauma, refugees The measures used in this study have been used across and asylum seekers are often subjected to a variety of multiple cultural groups. Accredited translators trans- postmigration stressors, including unemployment, inse- lated them into Turkish, Arabic, Farsi, and Tamil. Blind cure visa status, discrimination, and separation from back-translation procedures were also implemented 51
Morina et al. [35], with differences between the two translations with social worker”). The 17 items were rated on a five- being rectified by independent bilingual individuals expe- point scale (0 ¼ “not a problem” to 4 ¼ “very serious rienced in working with health-related questionnaires. problem”). Items scored at least 2 (“moderately serious Sociodemographic sample characteristics were as- problem”) were considered positive responses, yielding sessed at the beginning of the assessment. a total count of living difficulties. Trauma exposure was measured by combining the Procedures trauma event lists of two standardized questionnaires, the Harvard Trauma Questionnaire (HTQ) [36], and the The ethics committees of the respective Cantons of Post-traumatic Diagnostic Scale (PDS) [37,38]. This Downloaded from https://academic.oup.com/painmedicine/article-abstract/19/1/50/3062387 by guest on 11 February 2020 Zurich and Bern, Switzerland, approved the study (KEK- combined scale indexes exposure to 23 types of trau- ZH-Nr. 2011-0495). A therapist-assisted computer- matic events associated with the refugee experience based assessment tool (MultiCASI) was used to (i.e., brainwashing, torture, being close to death) and implement the self-report measures [48]. In MultiCASI, traumatic experiences associated with other civilian participants can read each item and the range of possi- trauma (i.e., natural disaster, serious accident, fire, or ble responses in their respective mother tongue on a explosion). A count of the number of types of traumatic tablet screen and—in case of illiteracy—can listen to the events experienced by each participant was computed. audio-recorded items/responses. Items are answered by touching the screen. A study team member ex- To measure PTSD symptom severity over the past plained the purpose of the study to potential partici- month, part three of the PDS [37,38] was used. The pants, including that the study would be performed PDS has been used with several refugee groups [39– anonymously and would have no influence on their sta- 41]. As data collection for this study was conducted tus of residence or asylum procedures. Written informed prior to publication of the DSM-5 in 2013, the additional consent was obtained from all participants. Participants items included in DSM-5 for the proposed PTSD diag- were informed that they were free to withdraw from the nostic criteria were added to the PDS [42,43]. study at any time without jeopardizing their ongoing According to the DSM-5, to meet criteria for PTSD one treatment. Participants attended a research assessment must initially be exposed to a traumatic event (Criterion of 60 to 120 minutes’ duration. Assessments were su- A). PTSD symptoms are then divided into four main cri- pervised by a psychiatrist, clinical psychologist, or a teria: Criterion B: intrusion symptoms; Criterion C: per- Master’s-level student of clinical psychology. sistent avoidance of stimuli associated with the trauma; Participants were reimbursed CHF 40 (approximately Criterion D: negative alterations in cognitions and mood; USD 40) for participation. Criterion E: alterations in arousal and reactivity. Probable PTSD diagnosis was determined by applying DSM-5 criteria to symptoms in the PDS [39]. Internal Data Analysis consistency for this scale was high (a ¼ 0.94). Analyses were conducted using SPSS version 22 Somatic symptoms were measured using the somatiza- (SPSS-IBM, INC). Exploratory factor analysis (principal tion subscale of the Symptom Checklist (SCL) [44]. This components) was used to derive somatization patterns subscale is a self-report inventory of 12 physical symp- based on the 12 SCL items. Two factors were retained, toms with strong autonomic mediation that are often as- with the criteria for extraction being an eigenvalue equal sociated with emotional distress. Symptom severity to or greater than 1. The factors were rotated by the di- during the last seven days is rated on a five-point Likert rect oblimin (oblique) function in order to obtain a sim- scale ranging from 0 ¼ “not at all” to 4 ¼ “extremely.” pler structure with greater interpretability. Items with a Items scored as 2 ¼ “moderately” or above are consid- loading higher than 0.40 on a given factor were consid- ered positive responses, yielding a total count of so- ered to contribute substantially to that factor. Only one matic symptoms. The SCL has been used with item failed to load to one of the two factors; for this rea- individuals from many cultural backgrounds [45]. In the son, we omitted this item. After deriving these two fac- current study, internal consistency was set at an tors, multiple linear regression (using the method a of 0.89. stepwise) was utilized to examine the relationship be- tween the two somatic symptom factors and pain as Overall pain over the past four weeks was assessed outcome variables and age, gender (Step 1), potentially with a single item on a five-point scale ranging from traumatic events and current living difficulties (Step 2), 0 ¼ “not at all” to 4 ¼ “extremely.” and PTSD core symptom clusters (Step 3) as indepen- dent variables. Assumptions for regression analyses A version of the Postmigration Living Difficulties were checked in terms of linearity of the relationships Checklist (PMLDC) [46,47] adapted to the Swiss context between somatic symptoms and independent variables, was used to examine the extent to which postmigration autocorrelation of residuals (Durbin-Watson challenges had been of concern to the individual over test ¼ 1.974), and homoscedasticity and normal distribu- the past 12 months (i.e., “communication difficulties,” tion of residuals, and all were found to be satisfactory. “discrimination,” “difficulties in interviews with immigra- Furthermore, we found no multicollinearity between in- tion officials,” “difficulties with employment,” “conflict dependent variables (all VIF < 1.7). 52
Trauma and Somatic Symptoms in Traumatized Refugees Results Table 1 Sample characteristics Participants in this study had a mean age of 42.4 years Variable (SD ¼ 9.9), and the sample comprised 78.4% (N ¼ 105) males. Participants reported having experienced a mean Male gender, N (%) 105 (78.4) of 13.11 (SD ¼ 4.80) types of traumatic events, with Age, mean (SD), y 42 (9.9) over 90% of the sample having experienced torture Nationality, N (%) (N ¼ 114, 92.7%) and a mean of 9.77 (SD ¼ 4.2) types Turkey (with N ¼ 58 being Kurdish) 71 (53.0) of living difficulties during the last 12 months. Iran 15 (11.2) Approximately half of the sample (N ¼ 66, 49.3%) had a Sri Lanka 11 (8.2) Downloaded from https://academic.oup.com/painmedicine/article-abstract/19/1/50/3062387 by guest on 11 February 2020 probable diagnosis of PTSD according to the DSM-5 Bosnia 6 (4.5) criteria. Further sociodemographic and sample charac- Iraq 6 (4.5) teristics are presented in Table 1. Afghanistan 5 (3.7) Others (i.e., Algeria, Bangladesh, 20 (14.9) An exploratory factor analysis of the 12 SCL items re- Ethiopia, Congo, Kosovo, Lebanon, vealed two distinct factors of somatic complaints. A fac- Liberia, Libya, Somalia, Syria, Tunesia) tor-loading matrix is shown in Table 2. The first factor, Years of education, N (%) with five items, was labeled “weakness” as it presented Less than 4 18 (10.4) high loadings of items referring to weakness, soreness, 4–8 25 (18.7) or heaviness symptoms and accounted for 45.7% of 8–12 39 (29.1) the variance. For this factor, the internal consistency was set at an a of 0.85. The second factor comprised 12þ 49 (36.6) six items and was characterized by high loadings of so- Employment status, N (%) matic symptoms predominantly associated with sympa- Full time 9 (6.79) thetic hyperactivation, such as chest pain or shortness Part time 17 (12.6) of breath, and was labeled “arousal.” This factor ex- Unemployed 82 (61.2) plained 10.3% of the variance, and the internal consis- Retired/homemaker 23 (17.1) tency was set at an a of 0.81. The item “hot or cold Duration of stay in Switzerland (SD), y 9.01 (6.67) spells” did not load on either factor. No. of experienced trauma types, mean 13.23 (4.54) (SD) The results of the correlation analyses are shown in Probable PTSD diagnosis, N (%) 66 (49.3%) Table 3. Multiple regression analyses revealed that only Number of somatic symptoms, mean (SD) 7.3 (3.5) symptoms of the PTSD Criterion D “alterations in cogni- Symptom scores, mean (SD) tions and mood” and Criterion E “alterations in arousal PTSD symptoms (range ¼ 0–60) 33.2 (13.8) and reactivity” symptoms were independently associ- PTSD Criterion B (range ¼ 0–15) 9.2 (4.0) ated with the “weakness” factor, accounting for 36% of PTSD Criterion C (range ¼ 0–6) 3.4 (1.9) the variance, while the “arousal” factor was associated PTSD Criterion D (range ¼ 0–21) 10.9 (5.3) with female gender, the PTSD Criterion E “alterations in PTSD Criterion E (range ¼ 0–18) 9.9 (4.5) arousal reactivity,” and the postmigration living difficul- Somatic symptoms ties, accounting for 32% of the variance (see Table 4). “Weakness” (range ¼ 0–4) 2.1 (0.9) Overall pain was associated with age, female gender, “Arousal” (range ¼ 0–4) 1.7 (0.8) living difficulties, and both PTSD Criteria D and E. Overall pain (range ¼ 0–4) 2.3 (1.2) Discussion This exploratory cross-sectional study examined the fac- PTSD symptom clusters as well as PMLD, with the tor structure of somatic symptoms (as assessed with highest correlations emerging with Criterion D (“negative the SCL) and the relationship of somatic symptoms and alterations in cognitions and mood”) and Criterion E (“al- pain with PTSD symptom clusters and postmigration liv- terations in arousal and reactivity”). However, while the ing difficulties in a clinical sample of severely trauma- “weakness” factor showed slightly higher correlations tized refugees. with PTSD symptoms, “arousal” was more strongly re- lated to PMLD. Regression analysis revealed that, when An exploratory factor analysis revealed two distinct fac- controlling for all variables simultaneously, while both tors of somatic complaints: Factor one included physical factors related to Criterion E, the “weakness” factor was perceptions in terms of bodily dysfunction and was re- additionally related to PTSD Criterion D and the ferred to as “weakness,” whereas factor two included “arousal” factor related to PMLD. Overall pain was re- somatic symptoms predominantly associated with sym- lated to PMLD and both PTSD CRITERIA D and E. pathetic hyperactivation and was referred to as “arousal.” Correlation analyses revealed that both fac- While the relationship between traumatic experiences, tors and overall pain were significantly related to all PTSD, and somatic complaints is well documented, this 53
Morina et al. Table 2 Summary of the factor loadings for the function that has been observed in PTSD [49]. somatization items of SCL (N ¼ 134) Conversely, potentially life-threatening somatic symp- toms such as shortness of breath or chest pain may re- Factor loadings sult in increased sympathetic activation, often accompanied by secondary symptoms such as hyper- Factor 1 Factor 2 ventilation, dizziness, muscular hypertension, and ten- Item “weakness” “arousal” sion headache [50,51]. Dizziness has been noted in prior traumatized populations, especially those from Soreness of 0.925 0.118 non-Western backgrounds; for example, dizziness has muscles been found to be a prominent complaint in a study on Downloaded from https://academic.oup.com/painmedicine/article-abstract/19/1/50/3062387 by guest on 11 February 2020 Numbness or tin- 0.813 0.251 traumatized Cambodians [51]. We also note that the gling in part of items in the “arousal” factor overlap with those of panic the body attacks; panic disorder is frequently comorbid with Pains in lower 0.726 0.356 PTSD [52], and it is possible that many of the refugees back in this sample had comorbid panic disorder. This possi- Heavy feeling in 0.719 0.263 bility cannot be clarified because comorbid disorders your arms or were not assessed. legs Feeling weak in 0.691 0.200 With regard to the “weakness” factor, a recent meta- parts of your analysis found traumatic experiences to be associated body with an increased prevalence of functional somatic syn- dromes (FSS), including fibromyalgia, chronic widespread Trouble getting 0.156 0.829 pain, and chronic fatigue syndrome [53]. Individuals re- your breath porting exposure to trauma had 2.7 times higher odds of Pains in heart or 0.082 0.747 having FSS. Combat exposure and PTSD had the stron- chest gest association with FSS. FSS typically accompanies Faintness or 0.060 0.698 complaints included in the “weakness” factor. Apart from dizziness sympathetic activation, the association of the “weakness” Headaches 0.135 0.602 factor and overall pain with the PTSD CRITERION of Nausea or upset 0.213 0.588 “negative alterations in cognitions and mood” is notable stomach and points to other potential mechanisms; for example, it Lump in your 0.350 0.490 is possible that the “weakness” symptoms may be asso- throat ciated with fatigue overreported in dysphoric states that Hot or cold spells 0.397 0.339 is incorporated in Criterion D. Variance, % 45.7 10.3 Internal a ¼ 0.85 a ¼ 0.81 Somatic Symptoms and PMLD consistency The association of somatic complaints (i.e., somatization Factor loadings higher than 0.40 are presented in bold. symptoms and pain) with postmigration living difficulties has attracted little research attention to date. While PMLDs have repeatedly been identified to be related to mental health problems in refugees over and above is one of the very first studies to examine distinct clus- trauma exposure [32,46,54–56], this is one of the first ters of somatic symptoms and pain, their association studies to our knowledge to show an association with with different PTSD clusters, and their association with regard to physical health complaints. The association of PMLD. Our findings suggest a model of triangular rela- PMLD with the PTSD Criterion E and the “arousal” fac- tion between the three elements: post-traumatic stress, tor and pain suggests a shared basis in terms of an ele- postmigration living difficulties, and somatic symptoms. vated stress level, in analogy to the above-cited Though by virtue of the cross-sectional study design the neurobiological and cognitive models. Again, it remains causal direction of the respective associations remains unclear whether PMLDs result in stress and stress- unclear, some subpatterns can be distinguished. associated somatic complaints, or if PTSD and somatic complaints would rather map into PMLD due to func- Somatic Symptoms and PTSD tional impairment, or a combination of both. The relationship between the “arousal” factor of somatic Apart from nonspecific elevated stress levels resulting symptoms and PTSD Criterion E is not surprising. PTSD from PMLD, another hypothesis for the relationship be- models have suggested that the relationship between tween somatic symptoms and PMLD is social rejection, pain and PTSD, particularly the arousal symptoms (i.e., in terms of social pain. Social rejection might be particu- hypervigilance, exaggerated startle response), is a func- larly perceived by refugees, who, after their displace- tion of sympathetic hyperactivation (or diminished para- ment, are confronted with often adverse social sympathetic activation) and the altered HPA-axis environments in hosting societies. In an experimental 54
Trauma and Somatic Symptoms in Traumatized Refugees Table 3 Pearson’s correlation of somatization symptoms and overall pain with potentially traumatic events, PTSD symptom criteria and living difficulties (N ¼ 134) 1 2 3 4 5 6 7 8 1 “Weakness” 2 “Arousal” 0.634** 3 Overall pain 0.658** 0.630** 4 PTE 0.208* 0.193* 0.120 Downloaded from https://academic.oup.com/painmedicine/article-abstract/19/1/50/3062387 by guest on 11 February 2020 5 PTSD Criterion B 0.349** 0.329** 0.278* 0.159 6 PTSD Criterion C 0.241** 0.233** 0.227* 0.179* 0.428** 7 PTSD Criterion D 0.439** 0.392** 0.385* 0.161 0.450** 0.501** 8 PTSD Criterion E 0.572** 0.511** 0.434* 0.300** 0.480** 0.441** 0.532** 9 PMLD 0.296** 0.340** 0.261* 0.201* 0.233** 0.221* 0.260** 0.267** Criterion B ¼ intrusion symptoms; Criterion C ¼ persistent avoidance of stimuli associated with the trauma; Criterion D ¼ negative alterations in cognitions and mood; Criterion E ¼ alterations in arousal and reactivity; PMLD ¼ postmigration living difficulties; PTE ¼ potentially traumatic events; PTSD ¼ post-traumatic stress disorder. *
Morina et al. Table 4 Summary of the multiple regression analyses of somatization factors and overall pain, age, gender, trauma, PTSD symptom criteria, and living difficulties (N ¼ 134) Outcome Independent Adjusted variable variable B SEB b T P F P R2 R2 “Weakness” 10.313 0.000 0.398 0.359 Age 0.014 0.007 0.139 1.960 0.052 Gender 0.067 0.166 0.028 0.400 0.690 Downloaded from https://academic.oup.com/painmedicine/article-abstract/19/1/50/3062387 by guest on 11 February 2020 Trauma 0.007 0.016 0.032 0.427 0.670 Living difficulties 0.033 0.017 0.144 1.937 0.055 PTSD Criterion B 0.150 0.245 0.052 0.613 0.541 PTSD Criterion C 0.203 0.178 0.097 1.141 0.256 PTSD Criterion D 0.438 0.187 0.213 2.344 0.021 PTSD Criterion E 0.881 0.184 0.434 4.783 0.000 “Arousal” 8.843 0.000 0.361 0.321 Age 0.011 0.006 0.124 1.694 0.093 Gender 0.313 0.150 0.153 2.087 0.039 Trauma 0.008 0.014 0.045 0.591 0.556 Living difficulties 0.044 0.016 0.215 2.819 0.006 PTSD Criterion B 0.186 0.221 0.073 0.844 0.401 PTSD Criterion C 0.131 0.160 0.071 0.816 0.416 PTSD Criterion D 0.272 0.168 0.151 1.618 0.108 PTSD Criterion E 0.640 0.166 0.360 3.861 0.000 Overall pain 7.285 0.000 0.322 0.277 Age 0.023 0.009 0.206 2.771 0.008 Gender 0.553 0.204 0.206 2.708 0.008 Trauma 0.002 0.020 0.007 0.088 0.930 Living difficulties 0.043 0.021 0.159 2.010 0.047 PTSD Criterion B 0.142 0.300 0.043 0.472 0.638 PTSD Criterion C 0.086 0.222 0.036 0.387 0.699 PTSD Criterion D 0.512 0.230 0.217 2.231 0.028 PTSD Criterion E 0.646 0.226 0.277 2.857 0.005 Criterion B ¼ intrusion symptoms; Criterion C ¼ persistent avoidance of stimuli associated with the trauma; Criterion D ¼ negative alterations in cognitions and mood; Criterion E ¼ alterations in arousal and reactivity; Gender ¼ 1: male, 2: female; Living difficul- ties ¼ count of postmigration living difficulties; PTSD ¼ post-traumatic stress disorder; Trauma ¼ count of experienced potentially traumatic events. Future research should include longitudinal studies con- involved in the conception of the study, in the analysis ducting multivariate analyses with larger sample sizes in and interpretation of the data, and in the drafting of the order to investigate indicators and causal factors, in manuscript. RB was involved in the conception of the which the two factors “weakness” and “arousal” are study, in the analysis and interpretation of the data, and related to aspects of trauma experience and in the drafting of the manuscript. AN was involved in the postmigration living difficulties. conception and design of the study, the analysis and in- terpretation of the data, and the drafting of the manu- script. MS was involved in the design of the study, the Authors’ Contributions acquisition, analysis and interpretation of the data, and the drafting of the manuscript. NM and AK contributed Naser Morina and Alexa Kuenburg contributed equally equally to this manuscript. All authors read and ap- to this article. proved the final manuscript. NM was involved in the conception and design of the study, the acquisition, analysis, and interpretation of the data, and the drafting of the manuscript. He is account- References able for all aspects of the work. AK was involved in the 1 UNHCR. Global trends UNHCR 2015. 2016. acquisition, analysis, and interpretation of the data and Available at: http://www.unhcr.org/576408cd7.pdf the drafting and the revision of the manuscript. US was (accessed August 20, 2016). 56
Trauma and Somatic Symptoms in Traumatized Refugees 2 Hollifield M, Warner TD, Nityamo L, et al. Measuring Examination of comorbidity with anxiety and depres- trauma and health status in refugees: A critical re- sion. J Trauma Stress 2002;15(5):415–21. view. J Am Med Assoc 2002;288(5):611–21. 15 Carlsson JM, Olsen DR, Mortensen EL, Kastrup M. 3 Fazel M, Wheeler J, Danesh J. Prevalence of serious Mental health and health-related quality of life: A 10- mental disorder in 7000 refugees resettled in west- year follow-up of tortured refugees. J Nerv Ment Dis ern countries: A systematic review. Lancet 2005;365 2006;194(10):725–31. (9467):1309–14. 16 Aragona M, Catino E, Pucci D, et al. The relation- 4 Johnson H, Thompson A. The development and ship between somatization and posttraumatic symp- Downloaded from https://academic.oup.com/painmedicine/article-abstract/19/1/50/3062387 by guest on 11 February 2020 maintenance of post-traumatic stress disorder toms among immigrants receiving primary care (PTSD) in civilian adult survivors of war trauma and services. J Trauma Stress 2010;23(5):615–22. torture: A review. Clin Psychol Rev 2008;28:36–47. 17 Rohlof HG, Knipscheer JW, Kleber RJ. Somatization 5 Heeren M, Mueller J, Ehlert U, et al. Mental health in refugees: A review. Soc Psychiatry Psychiatr of asylum seekers: A cross-sectional study of psy- Epidemiol 2014;49(11):1793–804. chiatric disorders. BMC Psychiatry 2012;12:114. 18 Schnurr PP, Green BL. Trauma and health: Physical 6 McFarlane AC, Atchison M, Rafalowicz E, Papay P. health consequences of exposure to extreme stress. Physical symptoms in post-traumatic stress disor- Washington, DC: American Psychological der. J Psychosom Res 1994;38(7):715–26. Association; 2004. 7 Otis JD, Keane TM, Kerns RD. An examination of 19 Schnurr PP, Jankowski MK. Physical health and the relationship between chronic pain and post- post-traumatic stress disorder: Review and synthe- traumatic stress disorder. J Rehabil Res Dev 2003; sis. Semin Clin Neuropsychiatry 1999;4(4):295–304. 40(5):397–405. 20 Rytwinski NK, Avena JS, Echiverri-Cohen AM, 8 Villano CL, Rosenblum A, Magura S, et al. Zoellner LA, Feeny NC. The relationships between Prevalence and correlates of posttraumatic stress posttraumatic stress disorder severity, depression disorder and chronic severe pain in psychiatric out- severity and physical health. J Health Psychol 2014; patients. J Rehabil Res Dev 2007;44(2):167–78. 19(4):509–20. 9 Norman SB, Stein MB, Dimsdale JE, Hoyt DB. Pain 21 Pietrzak RH, Goldstein RB, Southwick SM, Grant in the aftermath of trauma is a risk factor for post- BF. Physical health conditions associated with post- traumatic stress disorder. Psychol Med 2008;38 traumatic stress disorder in U.S. older adults: (4):533–42. Results from wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions. J Am 10 Gupta MA. Review of somatic symptoms in post- Geriatr Soc 2012;60(2):296–303. traumatic stress disorder. Int Rev Psychiatry 2013; 25(1):86–99. 22 Benyamini Y, Solomon Z. Combat stress reactions, posttraumatic stress disorder, cumulative life stress, 11 Pacella ML, Hruska B, Delahanty DL. The physical and physical health among Israeli veterans twenty health consequences of PTSD and PTSD symp- years after exposure to combat. Soc Sci Med (1982) toms: A meta-analytic review. J Anxiety Disord 2005;61(6):1267–77. 2013;27(1):33–46. 23 Sharp TJ, Harvey AG. Chronic pain and posttrau- 12 Taycan O, Sar V, Celik C, Erdogan-Taycan S. matic stress disorder: Mutual maintenance? Clin Trauma-related psychiatric comorbidity of somatiza- Psychol Rev 2001;21(6):857–77. tion disorder among women in eastern Turkey. Comprehensive Psychiatry 2014;55(8):1837–46. 24 Asmundson GJ, Coons MJ, Taylor S, Katz J. PTSD and the experience of pain: Research and clinical 13 Teodorescu DS, Heir T, Siqveland J, et al. Chronic implications of shared vulnerability and mutual main- pain in multi-traumatized outpatients with a refugee tenance models. Can J Psychiatry 2002;47 background resettled in Norway: A cross-sectional (10):930–7. study. BMC Psychol 2015;3(1):7. 25 Norton PJ, Asmundson GJG. Amending the fear- 14 van Ommeren M, Sharma B, Sharma GK, et al. The avoidance model of chronci pain: What is the role of relationship between somatic and PTSD symptoms physiological arousal? Behavior Therapy 2003;34 among Bhutanese refugee torture survivors: (1):17–30. 57
Morina et al. 26 Harris MF, Telfer BL. The health needs of asylum 38 Foa EB, Cashman L, Jaycox L, Perry K. The valida- seekers living in the community. Med J Aust 2001; tion of a self-report measure of posttraumatic stress 175(11–12):589–92. disorder: The Posttraumatic Diagnostic Scale. Psychol Assessment 1997;9(4):445–51. 27 Maier T, Schmidt M, Mueller J. Mental health and healthcare utilisation in adult asylum seekers. Swiss 39 Schnyder U, Müller J, Morina N, et al. Comparison Med Wkly 2010;140:w13110. of DSM-5 and DSM-IV Diagnostic Criteria for Posttraumatic Stress Disorder in Traumatized 28 Jongedijk RA. Narrative exposure therapy: An Refugees. J Trauma Stress 2015;28(4):267–74. evidence-based treatment for multiple and complex Downloaded from https://academic.oup.com/painmedicine/article-abstract/19/1/50/3062387 by guest on 11 February 2020 trauma. Eur J Psychotraumatol 2014;5:26522. 40 Vinson GA, Chang Z. PTSD symptom structure among West African war trauma survivors living in 29 Porter M, Haslam N. Predisplacement and postdis- African refugee camps: A factor-analytic investiga- placement factors associated with mental health of tion. J Trauma Stress 2012;25(2):226–31. refugees and internally displaced persons: A meta- analysis. JAMA 2005;294(5):602–12. 41 Onyut LP, Neuner F, Ertl V, et al. Trauma, poverty and mental health among Somali and Rwandese 30 Li SS, Liddell BJ, Nickerson A. The relationship be- refugees living in an African refugee settlement—An tween post-migration stress and psychological dis- epidemiological study. Confl Health 2009;3:6. orders in refugees and asylum seekers. Curr Psychiatry Rep 2016;18(9):82. 42 American Psychiatric Association. DSM-5: G 05 posttraumatic stress disorder. 2010. Available at: 31 Aragona M, Pucci D, Carrer S, et al. The role of http://www.dsm5.org/ProposedRevisions/Pages/pro post-migration living difficulties on somatization posedrevision.aspx?rid¼165. (accessed November among first-generation immigrants visited in a pri- 7, 2011) mary care service. Ann IST Super Sanita 2011;47 (2):207–13. 43 Friedman MJ, Resick PA, Bryant RA, Brewin CR. Considering PTSD for DSM-5. Depress Anxiety 32 Laban CJ, Gernaat HB, Komproe IH, Schreuders 2011;28(9):750–69. BA, De Jong JT. Impact of a long asylum procedure on the prevalence of psychiatric disorders in Iraqi 44 Derogatis LR. SCL-90-R: Administration, Scoring asylum seekers in The Netherlands. J Nerv Ment Dis and Procedure Manual - I. Baltimore, MD: John 2004;192(12):843–51. Hopkins; 1977. 33 Schweitzer R, Melville F, Steel Z, Lacherez P. 45 Derogatis LR, Unger, R. (2010). Symptom Checklist- Trauma, post-migration living difficulties, and social 90-Revised The Corsini Encyclopedia of Psychology: support as predictors of psychological adjustment in John Wiley & Sons, Inc. resettled Sudanese refugees. Aust N Z J Psychiatry 2006;40(2):179–87. 46 Silove D, Sinnerbrink I, Field A, Manicavasagar V, Steel Z. Anxiety, depression and PTSD in asylum-seekers: 34 Landa A, Bossis AP, Boylan LS, Wong PS. Beyond Associations with pre-migration trauma and post- the unexplainable pain: Relational world of patients migration stressors. Br J Psychiatry 1997;170(4):351–7. with somatization syndromes. J Nerv Ment Dis 2012;200(5):413–22. 47 Steel Z, Silove D, Bird K, McGorry P, Mohan P. Pathways from war trauma to posttraumatic stress 35 Bontempo R. Translation fidelity of psychological symptoms among Tamil asylum seekers, refugees, scales: An item response theory analysis of an and immigrants. J Trauma Stress 1999;12(3):421–35. individualism-collectivism scale. J Cross-Cult Psychol 1993;24:149–66. 48 Knaevelsrud C, Müller J. Multilingual Computer- Assisted Self-Interview (MultiCASI) System for 36 Mollica RF, Caspi-Yavin Y, Bollini P, et al. The Psychiatric Diagnostic of Migrants (Version 1.0). Harvard Trauma Questionnaire. Validating a cross- Heidelberg: Springer; 2007. cultural instrument for measuring torture, trauma, and posttraumatic stress disorder in Indochinese 49 Yehuda R. Advances in understanding neuroendo- refugees. J Nerv Ment Dis 1992;180(2):111–6. crine alterations in PTSD and their therapeutic impli- cations. Ann N Y Acad Sci 2006;1071(1):137–66. 37 Foa EB. Posttraumatic Diagnostic Scale Manual. Minneapolis, MN: National Computer Systems; 50 Liedl A, O’Donnell M, Creamer M, et al. Support for 1996. the mutual maintenance of pain and post-traumatic 58
Trauma and Somatic Symptoms in Traumatized Refugees stress disorder symptoms. Psychol Med 2010;40 literature and implications for the Canadian con- (7):1215–23. text—Part A. Soc Work Public Health 2012;27 (4):330–44. 51 Hinton DE, Kredlow MA, Pich V, Bui E, Hofmann SG. The relationship of PTSD to key somatic com- 55 Nickerson A, Steel Z, Bryant RA, Brooks R, Silove plaints and cultural syndromes among Cambodian D. Change in visa status amongst Mandaean refu- refugees attending a psychiatric clinic: The gees: Relationship to psychological symptoms and Cambodian Somatic Symptom and Syndrome living difficulties. Psychiatry Res 2011;187(1– Inventory (CSSI). Transcult Psychiatry 2013;50 2):267–74. Downloaded from https://academic.oup.com/painmedicine/article-abstract/19/1/50/3062387 by guest on 11 February 2020 (3):347–70. 56 Ryan DA, Benson CA, Dooley BA. Psychological 52 Cougle JR, Feldner MT, Keough ME, Hawkins KA, distress and the asylum process: A longitudinal Fitch KE. Comorbid panic attacks among individuals study of forced migrants in Ireland. J Nerv Ment Dis with posttraumatic stress disorder: Associations with 2008;196(1):37–45. traumatic event exposure history, symptoms, and impairment. J Anxiety Disord 2010;24(2):183–8. 57 Eisenberger NI. The pain of social disconnection: Examining the shared neural underpinnings of physi- 53 Afari N, Ahumada SM, Wright LJ, et al. cal and social pain. Nat Rev Neurosci 2012;13 Psychological trauma and functional somatic syn- (6):421–34. dromes: A systematic review and meta-analysis. Psychosom Med 2014;76(1):2–11. 58 Iffland B, Sansen LM, Catani C, Neuner F. Rapid heartbeat, but dry palms: Reactions of heart rate 54 Brabant Z, Raynault M-F. Health situation of mi- and skin conductance levels to social rejection. grants with precarious status: Review of the Front Psychol 2014;5:956. 59
You can also read