5th - Translational Immunology
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5
th
International Conference
of translational medicine
on pathogenesis and therapy
of immunomediated diseases
Innate immunity, inflammation
and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
www.translationalimmunology.it
PROGRAM
STEERING COMMITTEE
Francesco Annunziato
Massimo Locati
Domenico Mavilio
SCIENTIFIC COMMITTEE
Francesco Annunziato Enrico Lugli
Flavia Bazzoni Domenico Mavilio
Ennio Carbone Luis Montaner
Marco Cassatella William Nauseef
Raffaele De Palma Luigi Notarangelo
Francesca Di Rosa Isabella Quinti
Armando Gabrielli Angela Santoni
Francesca Granucci Antonio Sica
Massimo Locati Anna Villa
UNDER THE AUSPICES OF
5
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
WELCOME
Dear Colleagues,
we are all aware that conveying scientific discoveries into health improvement is a priority
for biomedical sciences in the 21st century. To contribute to this goal, the Italian Society of
Immunology, Clinical Immunology and Allergology (SIICA) is pleased to welcome you to the
“5th Conference on Translational Medicine on Pathogenesis and Therapy of Immunemediated
Diseases” in Milan, May 16th-18th, 2019.
The main goal of this meeting is to bring together clinicians, research scientists and industry
partners to discuss the medical advances from the laboratory to the clinic in the field of
immunopathology. Indeed, dysfunctions of both innate and adaptive immune responses play
key roles in the pathogenesis of a number of severe pathological conditions, including cancer,
infections, autoimmune and auto-inflammatory disorders, and primary immune-deficiencies.
The elucidation of immune mechanisms underlying the pathogenesis of these diseases is a
required experimental step for developing novel and alternative therapeutic strategies to finally
cure these pathologies and fill their several unmet clinical needs. In this 5th edition the meeting will
focus in particular on the contribution of inflammation in different prototypic immune-mediated
diseases representing a real burden for the society in terms of quality and duration of life.
As occurred in previous editions, in this meeting you will experience a high quality scientific
program with the presence of word renowned national and international speakers that will
discuss the latest advances in this field. Every section will include a keynote lecture delivered
by a pioneer in its research field, invited speakers, and short presentations selected from the
best submitted abstracts presented by young and skilled physicians and scientists. To enforce
interactions and scientific discussions, a very interactive social program with happy hours and
social dinners will be fully and freely accessible at all participants of the meeting.
In collaboration with biotech or pharmaceutical companies, we have also organized satellite
symposia to introduce the latest technologies available to investigate the pathogenetic
mechanisms underlying these diseases and new breakthrough drugs for their treatment.
All this will take place in the heart of Milan, a city famous for its history, fashion, culture and
food, and we will make sure you will also enjoy all these aspects of our city.
Hence, we welcome you in Milan!
Massimo Locati and Domenico Mavilio
Chairmen of the meeting on behalf of SIICA
1
5
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
CONTENTS
General information Page 3
Scientific Information Page 6
Conference Venue and Exhibition Area Page 7
Acknowledgements Page 8
Scientific Program
Thursday, May 16th Page 9
Friday, May 17 Page
th
11
Saturday, May 18th Page 14
Poster Session Page 18
Sponsored Sessions Page 34
Name Index Page 37
2
5
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
GENERAL INFORMATION
Conference Venue
Università degli Studi di Milano
Via Festa del Perdono, 7
20100 Milan - Italy
The Conference Venue is located in the city centre, ten minutes walking distance from Piazza
Duomo.
SIICA Secretariat
Rita Repizzi
Tel. +39 333 4398196
www.siica.org
siica.amministrazione@siica.it
Organizing Secretariat
Viale G. Matteotti, 7
50121 Florence, Italy
Tel. +39 055 50351 - Fax +39 055 5001912
siica2019@oic.it
The Organizing Secretariat desk will be open according to the following schedule:
Thursday, May 16th 12.00-20.00
Friday, May 17th 08.00-20.00
Saturday, May 18th 08.00-19. 1 0
Badge and Certificate of Attendance
Each participant receives a name badge upon check-in at the registration desk. The badge is
the official Conference pass and must be worn at all times.
Badges are colour-coded as follows:
= Faculty Member
Transparent = Participant
= Industry Member
Regularly registered participants receive a certificate of attendance included in the registration kit.
3
5
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
GENERAL INFORMATION
Coffee Breaks
Coffee breaks are offered to all regularly registered participants, in the coffee break area, as
indicated in the program.
Lunch Break
The Organizing Secretariat has concluded an agreement with some snack bar-restaurants,
walking distance from the Conference Venue. Each participant has to show the personal
conference badge at the cash desk to apply for a 10% discount on the bill.
C’Era una Volta Bistrot - Via Festa del Perdono, 14: open on May 16th and 17th - close on 18th
Bar Ateneo - Via Festa del Perdono, 14: open on May 16th, 17th and 18th
Bar Campus - Via Festa del Perdono, 12: open on May 16th, 17th and 18th
Grecale’s University Bar - Via Festa del Perdono: 12 open on May 16th and 17th - close on 18th
Registration Fees
Registration fees are in Euro (VAT 22% included).
Member SIICA * € 260,00
Member SIICA Under 35** € 210,00
Non Member SIICA € 290,00
Non Member SIICA Under 35 *** € 260,00
Delegate of the University of Milan € 260,00
*The reduced fee will be applied only to members with regular membership payments.
**The reduced fee will be applied only to members with regular membership payments. Copy of valid
document (ID or passport) to certify the date of birth is mandatory to be delivered at the registration desk
***Copy of valid document (ID or passport) to certify the date of birth is mandatory to be delivered at the
registration desk
Registration is mandatory for participation in the scientific sessions and for oral or poster
presenters.
Conference registration fee includes:
- Access to all scientific sessions
- Access to the exhibition area
- Conference kit and name badge
- Certificate of attendance
- Abstracts (digital)
- Welcome Cocktail on May 16th
- Social Dinner on May 17th
Cancellations and Refunds
For cancellations received until April 16th the paid fee will be refunded with a deduction of 70%
as penalty charge.No refund will be made for cancellations received after April 16th.
Should a delegate not attend the Conference, for whatever reasons, no further claims for
reimbursement can be made. All delegates are urged to take personal travel insurance.
45
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
GENERAL INFORMATION
Language
English is the official language of the Conference. No simultaneous translation is foreseen during
the scientific sessions.
WiFi
WiFi is available in the Conference Venue.
Username: unimi-convegni
Password: conferences@Unimi0519
In the Conference Venue is available the network EDUROAM.
Amazon Gift Card
As participant you will receive a card. Please visit all exhibitors with this card and ask them to
put their rubber stamp on their logo.
Once the card is complete with all the stamps, fill it in with your information and bring it to the
SIICA Secretariat Desk.
The winner will be drawn on May 18th during the Farewell.
The prize is a €100 value Amazon gift card.
SOCIAL PROGRAM
Welcome Cocktail
The welcome cocktail will take place on May 16th at the Conference Venue at 20.00.
Social Dinner
The Social Dinner wil take place on May 17th at the Conference Venue at 20.00. The dress code
for this evening is business informal.
All details will be given at the registration desk on site.
55
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
SCIENTIFIC INFORMATION
Session Schedule
Speakers are recommended to strictly respect the allotted time given for their presentations to
contribute to the smooth running of all scheduled Sessions.
Poster Sessions
Posters are display in the Poster Area. The Author is kindly requested to stand close to the poster
during the Poster Sessions for possible questions from participants.
The Poster Sessions are scheduled as follows:
Friday, May 17th from 13.30 to 14.30
Saturday, May 18th from 13.30 to 14.30
Abstract Book
The abstracts accepted as Oral Presentations and Posters are published on the Conference website.
Award Ceremony for the Best Poster
The Award Ceremony will take on May 18th during the Farewell. The prize is a €100 value
Amazon gift card.
Travel GRANT Awards
SIICA grants
Francesca Albano, Humanitas Clinic Institute, Rozzano, Italy
Martina Bonacini, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emiia, Italy
Mariantonia Braile, Interdepartmental Research Center in Basic and Clinical Immunological Sciences
Andrea Iannucci, University of Piemonte OrientaleSIICA
Ambra Natalini, University of Rome Sapienza, National Research Council, Rome, Italy
Raffaella Parente, Humanitas Research Hospital, Rozzano, Italy
Eva Piano Mortari, Pediatric Hospital ”Bambino Gesù”, Rome, Italy
Gianfranco Vitiello, University of Florence, Italy
EFIS grants
Ishaku Adamu, Nasarawa State University, Keffi, Nigeria
Giuseppe Ercolano, University of Lausanne, Switzerland
Chiara Farroni, Pediatric Hospital ”Bambino Gesù”, Rome, Italy
Darja Flegar, University of Zagreb School of Medicine, Croatia
Mahnaz Jamee, Alborz University of Medical Sciences, Karaj, Iran
Anna Kabanova, University of Siena, Italy
Daniela Latorre, ETH Zurich, Switzerland
Mohamed Mandour, University Catholique de Louvain, Belgium
Samuele Notarbartolo, Institute for Research in Biomedicine
Vincenzo Ronca, University of Milano - Bicocca School of Medicine, Italy
AIRC grants
Costanza Maria Cristiani, Magna Graecia University, Catanzaro, Italy
Leonardo Cristinziano, University of Naples Federico II, Italy
Maria Rosaria Galdiero, University of Naples Federico II, Italy
Barbara Mariotti, University of Verona, Italy
Irene Mattiola, Charité - Universitätmedizin Berlin, Germany
Valentina Tedeschi, Sapienza University of Rome, Italy
SLB grants
Elena Lo Presti, University of Palermo, Italy
Mariana Reis-Sobreiro, Universidade de Lisboa, Portugal
Ferdinando Oriolo, National Institutes of Health, Bethesda, USA - University of Milan and Humanitas Research
Hospital, Milan, Italy
Martin Pelletier, CHU de Québec-Université Laval Research Center, Canada
Margarita Dominguez Villar, New Haven, USA - Imperial College, London, United Kingdom
65 COFFEE BREAK AREA
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
CONFERENCE VENUE AND EXHIBITION AREA
COFFEE BREAK AREA
7 8 9 10 11 12
EXHIBITION
AREA 6 5 4 3 2 1
SLIDE
CENTRE
7 8 9 10 11 12
V
EXHIBITION
AREA 6 REGISTRATION
5 4 AREA
3 2 1 REGISTRATION AREA
SLIDE
CENTRE
V
REGISTRATION AREA REGISTRATION AREA
AULA MAGNA
AULA MAGNA
POSTER AREA
MAIN
ENTRANCE
Legenda
1 VODEN MEDICAL
5 BIO-RAD
9 FLUIDIGM MAI
ENTRA
INSTRUMENTS LABORATORIES CORPORATION
Booth number and Company Name
2 LABOSPACE 6 SHIRE ITALIA 10 EUROCLONE
Legenda
3 BIO-TECHNE 7 CHARLES RIVER
11 BIOGEM
LABORATORIES ITALIA
8 BIOLEGEND 12 PRODOTTI GIANNI
4 BECTON DICKINSON VODEN MEDICAL BIO-RAD FLUIDIGM
1 CAMPOVERDE
5 9
INSTRUMENTS LABORATORIES CORPORATION
2 LABOSPACE 6 SHIRE ITALIA 10 EUROCLONE
CHARLES RIVER
3 BIO-TECHNE 7 LABORATORIES ITALIA
11 BIOGEM
8 BIOLEGEND 12
4 BECTON DICKINSON
CAMPOVERDE
PRODOTTI GIANNI
75
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
ACKNOWLEDGEMENTS
The Italian Society of Immunology, Clinical Immunology and Allergology (SIICA)
would like to thank the following partners for their support
SILVER SPONSOR
EXHIBITORS AND SPONSORS
85
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
THURSDAY, 16th MAY 2019 AULA MAGNA
15.00-15.30 OPENING CEREMONY - Welcome and opening remarks
Massimo Locati, University of Milan and Humanitas Research Hospital, Milan, Italy
Domenico Mavilio, University of Milan and Humanitas Research Hospital, Milan, Italy
Angela Santoni, La Sapienza University, Rome, Italy
15.30-17.20 SESSION 1 - AUTOINFLAMMATION AND BEYOND
Supported by Society of Leukocyte Biology & Journal of Leukocyte Biology
Chairs: I vona Aksientevich, National Institutes of Health, Bethesda, USA
William Nauseef, University of Iowa, Iowa City, USA
15.30-15.50 Updates on pathophysiology of autoinflammatory diseases
Ivona Aksientevich, National Institutes of Health, Bethesda, USA
15.50-16.00 Phenotypical and functional characterization of innate immunity cells in
OP-01 Adenosine deaminase 2 deficiency (DADA-2)
Ferdinando Oriolo, National Institutes of Health, Bethesda, USA - University of
Milan and Humanitas Research Hospital, Milan, Italy
New advance in the treatment of autoinflammatory diseases
16.00-16.20
Marco Gattorno, Istituto Giannina Gaslini, Genoa, Italy
16.20-16.30 Cytokine secretion by blood leukocytes provides biotherapeutic options for
OP-02 patients suspected of chronic auto inflammatory syndromes
Martin Pelletier, CHU de Québec-Université Laval Research Center, Canada
16.30-16.50 Immunedysregulation and platelets: a new scenario in Wiskott Aldrich
Anna Villa, CNR, IRGB, SR-Tiget, San Raffaele, Milan, Italy
16.50-17.00 Regulation of Treg plasticity by the environment and its relevance in human
OP-03 autoimmune disease
Margarita Dominguez Villar, New Haven, USA - Imperial College, London,
United Kingdom
17.00-17.20 Discussion panel
17.20-17.50 Coffee break
95
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
THURSDAY, 16th MAY 2019 AULA MAGNA
17.50-19.10 SESSION 2 - NEW INSIGHTS IN HAEMATOPOIETIC STEM CELL TRANSPLANT
Chairs: M
arco A. Cassatella, University of Verona, Verona, Italy
Luca Castagna, Humanitas Research Hospital, Milan, Italy
Human cytomegalovirus reactivation in HSCT: present and future therapeutic
17.50-18.10
approaches
Fausto Baldanti, University of Pavia, Italy
18.10-18.30 CAR T cells and beyond - Clinics
Franco Locatelli, Ospedale Bambin Gesù, Rome, Italy
18.30-18.50 Highlights of viral infection in present allo HSCT practice
Raynier Devillier, Centre de Recherche en Cancèrologie de Marseille, Marseille,
France
18.50-19.10 Discussion panel
19.15-20.00
OPENING KEYNOTE LECTURE
Chair: Anna Villa, CNR, IRGB, SR-Tiget, San Raffaele, Milan, Italy
(Re)discovering primary immune deficiencies
Luigi Notarangelo, National Institutes of Health, Bethesda, USA
20.00 Welcome cocktail for all delegates
105
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
THURSDAY,
FRIDAY, 17th 16
MAYth
MAY
20192019 AULA MAGNA
08.30-09.15 KEYNOTE LECTURE
Chair: Luigi Notarangelo, National Institutes of Health, Bethesda, USA
Toward a genetic theory of childhood infectious diseases
Jean-Laurent Casanova, Rockfeller University, New York, USA
09.20-11.10 SESSION 3 - IMMUNODEFICIENCIES
Chairs: L
uigi Notarangelo, National Institutes of Health, Bethesda, USA
Anna Villa, CNR, IRGB, Milan, Italy
Rats, fleas, and autoinflammatory disease: familial Mediterranean fever and
09.20-09.40
Yersinia pestis
Dan Kastner, National Institutes of Health, Bethesda, USA
09.40-09.50 A monoallelic activating mutation in RAC2 resulting in a combined
OP-04 immunodeficiency
Vassilios Lougaris1, Janet Chou2, Abdallah Beano2, Jacqueline G. Wallace2,
Manuela Baronio1, Luisa Gazzurelli1, Tiziana Lorenzini1, Daniele Moratto1,
Giovanna Tabellini1, Silvia Parolini1, Michael Seleman2, Kelsey Stafstrom2,
Haiming Hu2, Raif S. Geha2, Alessandro Plebani1 ( 1Brescia - Italy, 2Boston - USA)
09.50-10.10 Human type I interferonopathies: insights into pathogenesis and therapy
Yanick J. Crow, University of Edinburgh, Edinburgh, United Kingdom
10.10-10.20 3D culture of BRAF-/KRAS-mutated Erdheim-Chester disease tissues unveils
OP-05 histiocyte metabolism as a new therapeutic target
Giulio Cavalli, Antonello Villa, Daniela Belloni, Barbara Vergani, Simone
Cenci, Riccardo Biavasco, Angelo D’Alessandro, Travis Nemkov,
Elena Casiraghi, Maria Giulia Cangi, Claudio Doglioni, Lorenzo Dagna,
Elisabetta Ferrero, Marina Ferrarini (Milan - Italy)
Anticytokine autoantibodies: what are they doing and what should we do
10.20-10.40
about it?
Steve Holland, National Institutes of Health, Bethesda, USA
10.40-10.50 Dysregulated miR-155 and miR-125b are related to impaired B-cell responses
OP-06 in down syndrome
Chiara Farroni1, Emiliano Marasco1, Valentina Marcellini1, Ezio Giorda1,
Diletta Valentini1, Stefania Petrini1, Valentina D’Oria1, Marco Pezzullo1,
Simona Cascioli1, Marco Scarsella1, Alberto G. Ugazio1, Giovanni C. De Vincentiis1,
Ola Grimsholm2, Rita Carsetti1 ( 1Rome - Italy, 2Gothenburg - Sweden)
10.50-11.10 Discussion panel
11.10-11.30 Coffee break
115
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
FRIDAY, 17th MAY 2019 AULA MAGNA
11.30-13.00 ATELLITE SYMPOSIUM (see page 34 )
S
IMMUNOLOGICAL THERAPIES AND MONITORING: TREATMENTS AND
READOUT HAVE NEVER BEEN MORE LINKED
13.00-13.30 Break
13.30-14.30 POSTER VIEW
14.30-16.20 SESSION 4 - AUTOIMMUNITY
Chairs: F
rancesco Annunziato, University of Florence, Florence, Italy
Pierluigi Meroni, IRCCS, Istituto Auxologico Italiano, Milan, Italy
14.30-14.50 Functional autoantibodiesin systemic sclerosis pathogenesis
Armando Gabrielli, University of Ancona, Ancona, Italy
IL-10 producing CCR6+T-cells are a distinct population of B-helper T-cells that
14.50-15.00
OP-07 play a pathogenic role in systemic Lupus erythematosus
Federica Facciotti, Paola Larghi, Roberto Bosotti, Nicola Gagliani,
Chiara Cordiglieri, Saveria Mazzara, Elsa Rottoli, Alessandra Penati,
Chiara Vasco, Bhavna Karnani, Mauro Bombaci, Maria Crosti, Maria
Carrabba, Lucia Augusta Baselli, Roberta Gualtierotti, Maria Gerosa,
Sara Torretta, Lorenzo Pignataro, Andrea Annoni, Fabio Russo, Giovanna
Fabio, Rosy Dellepiane, Sanders Tas, Sergio Abrignani, Fabio Grassi,
Massimiliano Pagani, Pierluigi Meroni, Richard Flavell, Jens Geginat
(Milan - Italy)
15.00-15.20 Manipulating regulatory T cell pathways to restore immune tolerance
Talal Chatila, Harward University, Boston, USA
15.20-15.30 Childhood vasculitis syndromes microscopic polyangiitis (MPA) and
OP-08 granulomatosis with polyangiitis (GPA) have different etiologies as indicated
by integrating blood transcriptomic and clinical metadata
M.L. Smith1, E.E. Gill1, K.M. Gibson1, K. Morishita1, J. Graham2, D. Foell3,
S. Benseler4, R. Luqmani5, C. Ross1, D.A. Cabral1, R.E.W. Hancock1, K.L. Brown1
( 1Vancouver - Canada, 2Burnaby - Canada, 3Muenster - Germany, 4Calgary -
Canada, 5Oxford - United Kingdom)
125
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
FRIDAY, 17th MAY 2019 AULA MAGNA
14.30-16.20 SESSION 4 - AUTOIMMUNITY (cont.)
Functional adaptation of Foxp3+ regulatory T cells in inflammatory diseases
15.30-15.50
Ciriaco A. Piccirillo, Montreal Diabetes Research Center, Montreal, Quebec, Canada
Loss-of-function variant in HSPG2 causes a familial form of monogenic
15.50-16.00
OP-09 systemic lupus erythematosus
Qinggang Li, Shunlai Shang, Yu Dong, Xiangmei Chen (Beijing - China)
16.00-16.20 Discussion panel
16.20-16.50 Coffee break
17.00-17.45 KEYNOTE LECTURE
Chair: Angela Santoni, La Sapienza University, Rome, Italy
Revisiting interleukin-2: biology and therapeutic advances
Abul Abbas, University of California, San Francisco, USA
20.00
S ocial dinner
135
th th
International
Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
SATURDAY, 18th MAY 2019 AULA MAGNA
08.30-09.15 KEYNOTE LECTURE
Chair: D
omenico Mavilio, University of Milan and Humanitas Research
Hospital, Milan, Italy
Natural killer cells in host defense against viral infection
Lewis Lanier, University of California, San Francisco, USA
09.15-10.15 SATELLITE SYMPOSIUM (see page 35)
FLOW TECHNOLOGY IN IMMUNOLOGY STUDIES
10.15-10.40 Coffee break
10.40-12.30 SESSION 5 - IMMUNITY TO INFECTIONS
Chairs: Emanuela Marcenaro, University of Genoa, Genoa, Italy
Luis Montaner, Wistar Institute, Philadelphia, USA
10.40-11.00 Vaccination, an achievement of civilization
Rino Rappuoli, GlaxoSmithKline Vaccines, Siena, Italy
Activation of cannabinoid receptor type-1 (CB1) and type-2 (CB2) inhibits
11.00-11.10
OP-10 the release of vascular endothelial growth factor (VEGF-A) from human neutrophils
Mariantonia Braile, Sara Scala, Luca Modestino, Anne Lise Ferrara,
Simone Marcella, Leonardo Cristinziano, Alessandro Barbato, Anna Ferraro,
Maria Rosaria Galdiero, Stefania Loffredo (Naples - Italy)
11.10-11.30 Novel immune-based approaches to cure HIV infection
Guido Silvestri, Emory University, Atlanta, USA
Broadly reactive T cells against Enterobacteriaceae are present in the naïve
11.30-11.40
OP-11 and enriched in the memory repertoire
Daniela Latorre1,2, Antonino Cassotta1,2, Jérémie Goldstein2, David Jarrossay1,2,
Franca Baggi Menozzi2, Mario Venditti3, Alessandro Russo4, Marco Falcone5,
Antonio Lanzavecchia1,2, Maria Cristina Gagliardi3, Federica Sallusto1,2 ( 1Zurich
- Switzerland, 2Bellinzona - Switzerland, 3Rome - Italy, 4Udine - Italy, 5Pisa - Italy)
A gut feeling: fatal attraction between HIV and Integrin alfa 4 beta 7
11.40-12.00
Paolo Lusso, National Institutes of Health, Bethesda, USA
Late development of FcεRγneg adaptive NK cells upon Human
12.00-12.10
OP-12 cytomegalovirus reactivation in Umbilical Cord Blood Transplantion recipients
Letizia Muccio1, Michela Falco1, Alice Bertaina2, Franco Locatelli2,
Francesco Frassoni1, Simona Sivori1, Lorenzo Moretta2, Alessandro Moretta1,
Mariella Della Chiesa1 ( 1Genoa - Italy, 2Rome - Italy)
12.10-12.30 Discussion panel
145
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
SATURDAY, 18th MAY 2019 AULA MAGNA
12.30-13.00 SATELLITE SYMPOSIUM (see page 36)
CHANGING MEMORY: MULTI-PARAMETER FLOW TO INTERROGATE T CELLS
FOLLOWING IMMUNOTHERAPY
13.00-13.30 Break
13.30-14.30 POSTER VIEW
14.30-15.15
KEYNOTE LECTURE
Chair: Guido Poli, San Raffaele Institute, Milan, Italy
Innate immunity, inflammation and cancer: double edged swords
Alberto Mantovani, Unimed and Humanitas Research Hospital, Milan, Italy
15.20-17.10 SESSION 6 - TUMOR IMMUNOLOGY
Chairs: A
ngela Santoni, La Sapienza University, Rome, Italy
Antonio Sica, University of Piemonte Orientale and Humanitas Research
Hospital, Milan, Italy
15.20-15.40 Deciphering the immune landscape of human cancer microenviroment
: Massimiliano Pagani, University of Milan and Istituto Nazionale Genetica
Molecolare, Milan, Italy
CXCR3 controls anti-myeloma efficacy of NK cells adoptively transferred
15.40-15.50
OP-13 for immunotherapy
Valentina Bonanni, Fabrizio Antonangeli, Angela Santoni,
Giovanni Bernardini (Rome - Italy)
New treatment strategies in the treatment of NSCLC
15.50-16.10
Marina Garassino, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Neutrophils driving unconventional T cells are essential for resistance to
16.10-16.20
OP-14 s arcomas
Andrea Ponzetta1, Roberta Carriero2, Silvia Carnevale1,
Marialuisa Barbagallo2, Martina Molgora1, Chiara Perucchini2,
Elena Magrini2, Paolo Kunderfranco2, Sabrina Di Marco2, Domenico Supino1,
Clelia Peano2, Ferdinando Cananzi2, Piergiuseppe Colombo2,
Cecilia Garlanda1, Alberto Mantovani2, Sebastien Jaillon1 ( 1Pieve Emanuele -
Italy, 2Rozzano - Italy)
155
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
SATURDAY, 18th MAY 2019 AULA MAGNA
15.20-17.10 SESSION 6 - TUMOR IMMUNOLOGY (cont.)
16.20-16.40 Enabling precision immuno-oncology in colorectal cancer
Zlatko Trajanoski
Medical University of Innsbruck, Austria
Phosphoproteomic analysis of CD2 signaling reveals a vast costimulatory
16.40-16.50
OP-15 network and identifies the pathway responsible for targeted granule secretion
in human cytotoxic T cells
Vanessa Zurli1, Tommaso Montecchi1, Giuliana Wimmer1, Oreste Acuto2,
Cosima Tatiana Baldari1, Anna Kabanova1 ( 1Siena - Italy, 2Oxford - United
Kingdom)
16.50-17.10 Discussion panel
17.10-17.30 Coffee break
17.30-18.10
MEMORIAL AND TRIBUTE TO THE MASTERS
Chairs: Federico Caligaris Cappio, AIRC President, Milan, Italy
D
omenico Mavilio, University of Milan and Humanitas Research
Hospital, Milan, Italy
Angela Santoni, La Sapienza University, Rome, Italy
Vito Pistoia: An outstanding scientist,a wonderful person and an unforgettable friend
17.30-17.40
Lorenzo Moretta, Ospedale Bambin Gesù, Rome, Italy
Luigi Varesio: A friend who perceived the role of tumor microphysiology in
17.40-17.50
antitumor immunity
Antonio Sica, University of Piemonte Orientale and Humanitas Research
Hospital, Milan, Italy
Alessandro Moretta: A wonderful journey in the land of NK cells with an
17.50-18.00
unforgettable friend
Franco Locatelli, Ospedale Bambin Gesù, Rome, Italy
Fernando Aiuti: An outstanding scientist, a pioneer in the recognition of
18.00-18.10
primary immunodeficiencies and in making AIDS a treatable disease
Isabella Quinti, La Sapienza University, Rome, Italy
165
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
SATURDAY, 18th MAY 2019 AULA MAGNA
18.10-18.55
KEYNOTE LECTURE
Chair: Lorenzo Moretta, Ospedale Bambin Gesù, Rome, Italy
Innate lymphoid cells: from discovery to cancer treatments
Eric Vivier, University of Marseille, Marseille, France
18.55-19.10 FAREWELL AND AWARD CEREMONY
Massimo Locati, University of Milan and Humanitas Research Hospital, Milan, Italy
D omenico Mavilio, University of Milan and Humanitas Research Hospital,
Milan, Italy
Angela Santoni, La Sapienza University, Rome, Italy
175
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
POSTER SESSION
P001 Gastric cancer and T memory cells: the clinical significance
Adamu Ishaku Akyala (Nigeria)
P002 Therapeutic faecal microbiota transplantation controls intestinal inflammation
through IL10 secretion by immune cells
Claudia Burrello1, Fulvia Milena Cribiù1, Jacopo Troisi2, Flavio Caprioli1,
Maria Rescigno1, Federica Facciotti1 ( 1Milan - Italy, 2Salerno - Italy)
P003 Mucosa-associated microbiota drives pathogenic functions in IBD-derived intestinal
iNKT cells
Claudia Burrello1, Maria Rita Giuffrè1, Ilaria Magagna1, Alice Bertocchi1,
Fulvia Milena Cribiù1, Fiorenzo Botti1, Antonio Di Sabatino2, Maurizio Vecchi1,
Maria Rescigno1, Flavio Caprioli1, Federica Facciotti1 (1Milan - Italy, 2Pavia - Italy)
P004 Different variants of immunopathogenesis of inflammatory bowel disease affect the
effectiveness of anti-TNF-α therapy
Anna Toptygina, Svetlana Petrichuk, Elena Semikina (Moscow - Russia)
P005 Combined indirect immunofluorescence and solid phase assay reflex strategy in the
determination of anti-nuclear and extractable nuclear autoantibodies
Gianfranco Vitiello, Boaz Palterer, Linda Giulietti, Maria Grazia Giudizi,
Paola Parronchi (Florence - Italy)
P006 Role of butyrylcholinesterase polymorphisms in relapsing remitting-multiple sclerosis
(RR-MS) patients
Marcella Reale1, Marco D’Aurora1, Marta Di Nicola1, Claudio Gasperini2,
Ada Maria Tata2, Chiara D’Angelo1, Erica Costantini1, Valentina Gatta1 ( 1Chieti - Italy,
2
Rome - Italy)
P007 The D-aspartate effects on neurosteroids, neurosteroid receptors, and inflammatory
mediators in experimental autoimmune encephalomyelitis
Mahdi Goudarzvand1, Gholamreza Azizi1, Mahnaz Jamee2 ( 1Karaj - Iran, 2Alborz -
Iran)
P008 Potential therapeutic targets for noninfectious uveitis gathered through cytokine
profiling In aqueous humor samples
Martina Bonacini1, Alessandra Soriano1, Luca Cimino1, Luca De Simone1,
Elena Bolletta1, Lucia Belloni1, Alessandro Zerbini1, Francesco Muratore1,
Luigi Fontana1, Carlo Salvarani2, Stefania Croci1 ( 1Reggio Emilia - Italy, 2Modena - Italy)
P009 Immune-regulatory phenotype of newly diagnosed Graves’ disease, with special
regards to micronutrients: preliminary data from a pilot study
Daniela Gallo, Simona Antonia Maria Cattaneo, Jessica Sabatino, Linda Gentile,
Francesca Merletti, Monia Nisi, Carlo Peruzzo, Marco Ferrario, Douglas Noonan,
Luigi Bartalena, Lorenzo Mortara, Eliana Piantanida (Varese - Italy)
185
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
POSTER SESSION
P010 The long-non-coding RNA NRIR drives IFN-response in monocytes: implication for
Systemic Sclerosis
Barbara Mariotti1, Nila H. Servaas2, Nicola Tamassia1, Marco A. Cassatella1, Marta
Cossu2, Lorenzo Beretta3, Timothy R.D.J. Radstake2, Marzia Rossato1, Flavia Bazzoni1
( 1Verona - Italy, 2Utrecht - Netherlands, 3Milan - Italy)
P011 Immunogenic activity of neutrophil extracellular trap in systemic lupus
erythematosus and lupus nephropathy
Roberta Bertelli, Francesca Schena, Maurizio Bruschi, Francesca Antonini, Genny
Del Zotto, Daniele Reverberi, Fabrizio Loiacono, Giovanni Candiano, Marco Gattorno,
Stefano Volpi, Gian Marco Ghiggeri (Genoa - Italy)
P012 A pharmacogenetic study implicates NINJ2, a regulator of endothelial inflammation
and activation, in the response to IFNbeta in multiple sclerosis
Silvia Peroni1, Melissa Sorosina1, Sunny Malhotra2, Ferdinando Clarelli1, Laura Ferrè1,
Tina Roostaei3, Luisa Maria Villar4, Nino Spataro2, Vittorio Martinelli1, Howard
Weiner5, Phil De Jager3, Giancarlo Comi1, Federica Esposito1, Manuel Comabella2,
Filippo Martinelli Boneschi1 ( 1Milan - Italy, 2Barcelona - Spain, 3New York - USA,
4
Madrid - Spain, 5Boston - USA)
P013 CD8 T cell effectors are increased in the blood of patients with psoriatic arthritis and
migrate towards synovial fluid
Marco Diani1, Fabio Casciano2, Laura Marongiu1, Matteo Longhi1, Andrea Altomare1,
Paola Secchiero2, Roberto Gambari2, Giuseppe Banfi1, Angelo Manfredi1,
Francesca Granucci1, Eva Reali1 ( 1Milan - Italy, 2Ferrara - Italy)
P014 The effect of inhibition of CCL2/CCR2 signaling on myeloid lineage cells and
osteoclast progenitor subpopulation in collagen induced arthritis
Darja Flegar, Alan Sucur, Antonio Markotic, Nina Lukac, Dino Sisl, Natasa Kovacic,
Tomislav Kelava, Vedran Katavic, Katerina Zrinski Petrovic, Danka Grcevic (Zagreb
- Croatia)
P015 Identification and characterization of two divergent human TH17 cells subsets
Dominik Aschenbrenner1, Mathilde Foglierini2, David Jarrossay2, Dan Hu3,
Howard L. Weiner3, Vijay K. Kuchroo3, Antonio Lanzavecchia2, Federica Sallusto2,
Samuele Notarbartolo2 (Oxford - United Kingdom, 2Bellinzona - Switzerland, 3Boston -
USA)
P016 Proteomic analysis of neutrophils in vasculitis associated with anti-proteinase 3
ANCA reveals a dysregulation in cytosolic and membrane proteins associated with
proteinase 3 and involved in apoptotic cell clearance : key role of annexin-A1
Judith Everts-Graber 1, Katherine Martin1, Nathalie Thieblemont1, Philippe Frachet2,
Mauro Perretti3, Luc Mouthon1, Veronique Witko-Sarsat1 ( 1Paris - France, 2Grenoble -
France, 3London - United Kingdom)
195
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
POSTER SESSION
D efective chemokine response of peripheral CD8+ T cells in patients with Ankylosing
P017
Spondylitis parallels with an intrinsic hypermotility
Valentina Tedeschi1, Fabiana Paladini1, Eugenia Principato1, Giorgia Paldino1,
Annamaria Iuliano1, Marino Paroli1, Alberto Cauli2, Rosa Sorrentino1,
Maria Teresa Fiorillo1 ( 1Rome - Italy, 2Cagliari - Italy)
P018 Follicular regulatory T cells are increased in the peripheral blood of subjects with
multiple islet-autoantibodies but are reduced in the pancreatic lymph nodes of
patients with T1D
Andrea Vecchione1, Kimberly Shankwitz2, Jolanda Gerosa1, Tatiana Jofra1,
Roberta di Fonte1, Maria Pia Cicalese1, Andrew Schultz3, Vincenzo Napoleone4,
Howie Seay3, Davide Cittaro1, Donatella Biancolini1, Francesca Ragogna1,
Angela Stabilini1, Pauline Gragon1, Eleonora Bianconi1, Clara Bonura1,
Riccardo Bonfanti1, Alberto Laurenzi1, Giulio Frontino1, Rita Nano1, Raffaela Melzi1,
Emanuele Bosi1, Lorenzo Piemonti1, Alessandro Aiuti1, Todd Brusko1,
Costantinos Petrovas2, Manuela Battaglia1, Georgia Fousteri1 ( 1Milan - Italy, 2Bethesda -
USA, 3Gainesville - USA, 4Florence - Italy)
P019 Phenotypic and functional landscape of B-cells in essential mixed cryoglobulinemia
Ylenia-Aura Minafò, Martina Del Padre, Stefania Colantuono, Massimo Fiorilli,
Milvia Casato, Marcella Visentini (Rome - Italy)
P020 Human umbilical cord-derived MSC could significantly attenuate renal lesions by
regulating abnormal immune response in rat IgA nephropathy
Xue-Yuan Bai, Yingjie Zhang, Xiaoyuan Wu, Xiangmei Chen (Beijing - China)
P021 Generation of in vitro models of the Aicardi-Goutières syndrome to dissect
mechanisms of physiopathology
Anna Maria Sole Giordano, Marco Luciani, Alessandro Migliara, Giacomo Frati,
Francesca Gatto, Luigi Naldini, Angelo Lombardo, Angela Gritti,
Anna Kajaste-Rudnitski (Milan - Italy)
P022 Analysis of the dynamics of T lymphocytes in patients and in NLRP3 Knock-in mice
affected by Cryopyrin Associated Periodic Syndromes (CAPS), for the evaluation of
new therapeutic targets
Giuseppina Astone, Arinna Bertoni, Daniela Fenoglio, Sabrina Chiesa,
Marco Gattorno, Gilberto Filaci (Genoa - Italy)
P023 The anti-inflammatory cytokine interleukin 37 is an endogenous inhibitor of trained
immunity
Giulio Cavalli1, Mark Gresnict2, Travis Nemkov3, Rob Arts2, Angelo D’Alessandro3,
Silvia Giugliano4, Lorenzo Dagna1, Leo Joosten2, Mihai Netea2, Charles Dinarello1
( 1Milan - Italy, 2Nijmegen - Netherlands, 3Aurora - USA, 4Rozzano - Italy)
205
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
POSTER SESSION
P024 High levels of IGE against tissue factor and thyroglobulin are reduced by
omalizumab in chronic spontaneous urticaria
Giovanni Genovese1, Riccardo Asero2, Silvia Ferrucci1, Maurizio Lorini1,
Vincenzo Carbonelli1, Emilio Berti1, Angelo Valerio Marzano1, Massimo Cugno1
( 1Milan - Italy, 2Paderno Dugnano - Italy)
P025 The long pentraxin PTX3 has a non-redundant role in the control of Streptococcus
pneumoniae invasive infections
Remi Porte1, Raffaella Parente1, Rita Gomez1, Fabio Pasqualini1, Camilla Recordati1,
Andrea Doni1, Tom van der Poll2, Cecilia Garlanda1, Barbara Bottazzi1, Alberto
Mantovani1 ( 1Milan - Italy, 2Amsterdam - Netherlands)
P026 Nailfold videocapillaroscopic findings in hereditary angioedema with C1-inhibitor
deficiency
Azzurra Marcelli Cesoni, Maria Bova, Angelica Petraroli, Anne Lise Ferrara,
Luca Modestino, Maria Rosaria Galdiero, Leonardo Cristinziano, Mariantonia Braile,
Simone Marcella, Stefania Loffredo (Naples - Italy)
P027 Expanded CD56BRIGHT NK cells in a SCID patient carrying the R222C mutation in the
IL-2 receptor g-chain
Cristina Cifaldi1, Silvia Di Cesare1, Nicola Cotugno1, Gigliola Di Matteo1, Silvia Giliani2,
Paola Zangari1, Maia De Luca1, Carmen Giancotta1, Donato Amodio1, Paolo Rossi1,
Paolo Palma1, Andrea Finocchi1, Margherita Doria1, Caterina Cancrini1 ( 1Rome - Italy,
2
Brescia - Italy)
P028 Adenosine deaminase 2 deficiency: characterization and correction of the immune
cell defects by gene therapy
Immacolata Brigida1, Matteo Zoccolillo1, Francesca Schena2, Antonella Insalaco3,
Claudia Sartirana1, Serena Scala1, Luca Basso-Ricci1, Raisa Jofra Hernandez1,
Giulia Milardi1, Federica Barzaghi1, Marco Gattorno2, Fabrizio De Benedetti3,
Maria Pia Cicalese1, Alessandra Mortellaro1, Alessandro Aiuti1 ( 1Milan - Italy, 2Genoa -
Italy, 3Rome - Italy)
P029 Non-genotoxic conditioning CD45-SAP promotes an adequate immunological
reconstitution in a mouse model of severe combined immunodeficiency caused by
RAG1 defect
Maria Carmina Castiello1, Nicolò Sacchetti1, Elena Draghici1, Ileana Bortolomai1,
Elena Fontana1, Lucia Sereni1, David T. Scadden2, Marita Bosticardo3,
Luigi D. Notarangelo3, Anna Villa1 ( 1Milan - Italy, 2Boston - USA, 3Bethesda - USA)
215
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
POSTER SESSION
P030 Prognostic values of post-vaccination anti-PS23 IGM and IGA levels phenotypes in
common variable immunodeficiency: a longitudinal study
Federica Pulvirenti, Filomena Monica Cavaliere, Cinzia Milito, Isabella Quinti
(Rome - Italy)
P031 Weighted gene co-expression network analysis identifies specific modules and hub
genes related to atypical hemolytic uremic syndrome
Mohamed El-Hadi Seninet1, Kheir Eddine Kerboua2, Mohamed Belhocine3,
Leila Saadi1 ( 1Blida - Algeria, 2Ouargla - Algeria, 3Dubai - United Arab Emirates)
P032 X-linked chronic granulomatosis: molecular and cellular mechanisms underlying
intestinal inflammation
Maria Chiriaco1, Martina Pellicciotta2, Silvia Di Cesare1, Elena Fontana2, Rosita
Rigoni2, Francesca Rea1, Anna Villa2,3, Simone Guglielmetti3, Andrea Finocchi1,
Barbara Cassani2,3 ( 1Rome - Italy, 2Rozzano - Italy, 3Milan - Italy)
P033 Rac2 regulates human NK cell biology
Vassilios Lougaris1, Giovanna Tabellini1, Ornella Patrizi1, Manuela Baronio1,
Luisa Gazzurelli1, Tiziana Lorenzini1, Janet Chou2, Raif S. Geha2, Silvia Parolini1,
Alessandro Plebani1 ( 1Brescia - Italy, 2Boston - USA)
P034 Distinct phenotype of human memory B cells define different type of immune deficiency
Eva Piano Mortari1, Ola Grimsholm2, Chiara Bocci1, Caterina Cancrini1, Ezio Giorda1,
Rita Carsetti1 ( 1Rome - Italy, 2Gothenburg - Sweden)
P035 The strategy of the human memory B cell response changes throughout life
Eva Piano Mortari1, Ola Grimsholm2, Alexey Davidov3, Mikhail Shugay4,
Emiliano Marasco1, Chiara Bocci1, Chiara Farroni1, Ezio Giorda1, Sabina Barresi1,
Domenico Alessandro De Silvestris1, Angela Gallo1, Cristina Cristofoletti1,
Marco Tartaglia1, Franco Locatelli1, Dmitry Chudakov4, Rita Carsetti1 ( 1Rome - Italy,
2
Gothenburg - Sweden, 3Brno - Czech Republic, 4Moscow - Russia)
P036 Thymic epithelium abnormalities in DiGeorge and Down syndrome patients
contribute to dysregulation in T cell development
Genni Enza Marcovecchio1, Ileana Bortolomai1, Francesca Ferrua1, Elena
Fontana1, Luisa Imberti2, Erika Conforti3, Donato Amodio4, Sonia Bergante3, Giulia
Macchiarulo4, Veronica D’Oria3, Francesca Conti4, Silvia Di Cesare4, Georgia
Fousteri1, Adriano Carotti4, Alessandro Giamberti3, Pietro Luigi Poliani2, Caterina
Cancrini4, Anna Villa1, Marita Bosticardo1 ( 1Milan - Italy, 2Brescia - Italy, 3San Donato
Milanese - Italy, 4Rome - Italy)
The impact of intestinal microbial landscape on clinical outcomes of WAS patients
P037
undergoing gene therapy
Rosita Rigoni, Genni Enza Marcovecchio, Maria Carmina Castiello,
Francesca Ferrua, Renée Pasciuta, Vera Gallo, Miriam Casiraghi, Paola Ballatore,
Nicasio Mancini, Alessandro Aiuti, Maria Pia Cicalese, Anna Villa (Milan - Italy)
225
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
POSTER SESSION
P038 Registry to collect long term safety data from pregnant women treated with
recombinant human hyaluronidase-facilitated subcutaneous immunoglobulin
Michael Borte1, Stefan Raffac2, Martin Hrubisko3, Karina Jahnz-Rozyk4,
Milada Cvackova5, Heinz Leibl6, Gaia A. Luppino7, Leman Yel8 ( 1Leipzig - Germany,
2
Kosice - Slovakia, 3Bratislava - Slovakia, 4Warsaw - Poland, 5Prague - Czech Republic,
6
Vienna - Austria, 7Milan - Italy, 8Cambridge - USA)
P039 Isohemagglutinin in adult hypogammaglobulinemic patients: friend or foe?
Riccardo Capecchi, Alessandro Ghilarducci, Francesca Angelotti, Donatella Sutera,
Valeria Rocchi, Paola Migliorini (Pisa - Italy)
P040 Isolated congenital asplenia with Waterhouse-Friderichsen syndrome and
pneumococcal septic shock
Maia De Luca1, Francesca Conti1, Donato Amodio1, Nicola Cotugno1, Paola Zangari1,
Lorenza Romani1, Carmela Giancotta1, Silvia Giliani2, Gigliola Di Matteo1,
Silvia Di Cesare1, Patrizia D’Argenio1, Paolo Palma1, Andrea Finocchi1, Paolo Rossi1,
Caterina Cancrini1 ( 1Rome - Italy, 2Brescia - Italy)
P041 Hyperige syndrome and DOCK8 deficiency: the case of a 2-year-old female
Maia De Luca1, Francesca Conti1, Donato Amodio1, Nicola Cotugno1, Paola Zangari1,
Carmela Giancotta1, Lorenza Romani1, Silvia Giliani2, Gigliola Di Matteo1,
Silvia Di Cesare1, Patrizia D’Argenio1, Paolo Palma1, Andrea Finocchi1, Paolo Rossi1,
Caterina Cancrini1 ( 1Rome - Italy, 2Brescia - Italy)
CD99 and its ligand in the regulation of immune responses
P042
Supansa Pata, Nuchjira Takheaw, Papawadee Ea-Wong, Witida Laopajon,
Watchara Kasinrerk (Chiang Mai - Thailand)
CD99 on monocytes play functional role in T cell activation
P043
Witida Laopajon, Nuchjira Takheaw, Saichit Khummuang, Supansa Pata, Watchara
Kasinrerk (Chiang Mai - Thailand)
Altered metabolism of phospholipases, diacylglycerols, endocannabinoids and
P044
N-acylethanolamines in patients with mastocytosis
Anne Lise Ferrara1, Luca Modestino1, Mariantonia Braile1, Leonardo Cristinziano1,
Simone Marcella1, Maria Rosaria Galdiero1, Anna Ferraro1, Angelica Petraroli1,
Roberta Parente2, Massimo Triggiani2, Vincenzo Di Marzo1, Stefania Loffredo1 ( 1Naples
- Italy, 2Salerno - Italy)
Unravelling the response of chronic lymphocytic leukemia to a novel class of anti-
P045
cancer agents, the pyrrolonaphthoxazepines (PNOXs)
Francesca Vanni1, Ludovica Lopresti1, Tuhina Khan1, Daniela M. Zisterer2,
Francesca Cattaneo1, Vanessa Zurli1, Kabanova Anna1, Monica Bocchia1,
Giuseppe Campiani1, Cosima T. Baldari1, Stefania Butini1, Cristina Ulivieri1 ( 1Siena -
Italy, 2Dublin - Ireland)
235
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
POSTER SESSION
P046 The role of IL-17s/IL-17Rs immune axis in airway defense and immunopathology
Giulia Rizzo, Alessandro Migliara, Barbara Sipione, Fabio Saliu,
Alessandra Bragonzi, Cristina Cigana, Angelo Lombardo, Nicola Lorè (Milan - Italy)
The glycoengineered tumor-targeting mAb Obinutuzumab acts via FcgammaRIIIA/
P047
CD16 to promote miR-155 upregulation associated to the priming for IFN-gamma
production in Natural Killer cells
Cristina Capuano1, Chiara Pighi1, Roberta Maggio1, Simone Battella1,
Stefania Morrone1, Gabriella Palmieri1, Angela Santoni1, Christian Klein2,
Ricciarda Galandrini1 ( 1Rome - Italy, 2Schlieren - Switzerland)
Circulating leukocytes abnormalities in chronic obstructive pulmonary disease
P048
(COPD)
Natalia Troianova, Barbara Mariotti, Francesco Spelta, Valentina Micheletti,
Marcello Ferrari, Flavia Bazzoni (Verona - Italy)
Metabolic conversion of IP3 to IP4 is required to operate Ca2+ entry and NFAT
P049
activation in dendritic cells in response to LPS
Laura Marongiu1, Francesca Mingozzi1, Clara Cigni1, Roberta Marzi2,
Marco Di Gioia3, Massimiliano Garrè1, Dario Parazzoli1, Laura Sironi1,
Maddalena Collini1, Reiko Sakaguchi4, Takashi Morii4, Maria Cristina Crosti1,
Monica Moro1, Stéphane Schurmans5, Rany Rotem1, Miriam Colombo1, Davide
Prosperi1, Ivan Zanoni1, Francesca Granucci1
( 1Milan - Italy, 2Bellinzona - Switzerland, 3Boston - USA, 4Kyoto - Japan, 5Liège - Belgium)
Characterization of tuberculosis-specific immune response of patients with latent
P050
tuberculosis infection and rheumatic disorders
Elisa Petruccioli, Teresa Chiacchio, Valentina Vanini, Gilda Cuzzi, Fabrizio Palmieri,
Giuseppe Ippolito, Delia Goletti (Rome - Italy)
Performance of a new whole-blood test for detecting reactivation of echinococcal cysts
P051
Linda Petrone1, Francesca Tamarozzi1, Ambra Vola2, Maria Angeles Gomez Morales1,
Mara Mariconti2, Enrico Brunetti2, Delia Goletti1 ( 1Rome - Italy, 2Pavia - Italy)
Long-term graft tolerance induction by NFATc pathway inhibition in innate immune cells
P052
Laura Gornati1, Clara Cigni1, Francesca Mingozzi1, Laura Marongiu1, Rany Rotem1,
Miriam Colombo1, Davide Prosperi1, Ivan Zanoni2, Francesca Granucci1 ( 1Milan - Italy,
2
Boston - USA)
Identification of a miR-146b-FasL axis in the development of neutropenia in T-LGL
P053
leukemia
Barbara Mariotti1, Marzia Rossato2, Antonella Teramo3, Giulia Calabretto3, Gregorio
Barilà3, Matteo Leoncin3, Cristina Vicenzetto3, Monica Facco3,
Gianpietro Semenzato3, Renato Zambello3, Flavia Bazzoni1 ( 1Verona - Italy, 2Padua - Italy)
245
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
POSTER SESSION
Functional cooperation between complement factor H and the long pentraxin PTX3
P054
in the immune response to Aspergillus fumigatus
Raffaella Parente1, Francesca Petroni1, Matteo Stravalaci1, Marina Sironi1, Roberto
Leone1, Sonia Valentino1, Anthony Jay Day2, Barbara Bottazzi1, Alberto Mantovani1,
Antonio Inforzato1 ( 1Rozzano - Italy, 2Manchester - United Kingdom)
Novel technological approaches to explore epigenome compartmentalization in
P055
CD4+ T cells
Federica Lucini1, Sara Valsoni2, Laura Antonelli3, Francesco Gregoretti3,
Gennaro Oliva3, Chiara Lanzuolo1 ( 1Milan - Italy, 2Rome - Italy, 3Naples - Italy)
The role of innate immune receptors in Candida albicans skin infections
P056
Irene Artuso1, Francesco Borriello2, Ivan Orlandi1, Giulia Stamerra1, Marina Vai1,
Ivan Zanoni2, Francesca Granucci1 (Milan - Italy, 2Boston - USA)
Innate immune response against Plasmodium falciparum gametocytes:
P057
phagocytosis and activation of bone marrow derived macrophages
Sarah D’Alessandro1, Silvia Parapini1, Valeria Messina2, Francesco Silvestrini2,
Loredana Cavicchini1, Paola Misiano1, Donatella Taramelli1, Nicoletta Basilico1,
Yolanda Corbett1 ( 1Milan - Italy, 2Rome - Italy)
The extracellular AIM2-like receptor IFI16 binds to LPS with high affinity and boosts
P058
inflammatory cytokine production
Andrea Iannucci1, Valeria Caneparo1, Valentina Salogni1, Santo Landolfo2,
Marisa Gariglio1, Marco De Andrea2 ( 1Novara - Italy, 2Turin - Italy)
CD45LOW and CD45HIGH human interleukin-10 (IL-10) producing B regulatory cells
P059
depend variably on BTK and mtor for survival and IL-10 production
Vassilios Lougaris, Manuela Baronio, Luisa Gazzurelli, Tiziana Lorenzini,
Daniele Moratto, Raffaele Badolato, Alessandro Plebani (Brescia - Italy
Effects of dextran oxygen-loaded nanodroplets on macrophages inflammatory
P060
response during hypoxia
Federica Perego1, Sarah D’Alessandro1, Silvia Parapini1, Rosalia Maria Ticozzi1, Mauro
Prato2, Bruno Bressan2, Adriano Troia2, Serena Delbue1, Nicoletta Basilico1 ( 1Milan -
Italy, 2Turin - Italy)
Sphingosine1-phosphate/sphingosine kinases axis contribute to determine
P061
polarization and function of T helper cells
Giusi Barra1, Alessio Lepore1, Miriam Gagliardi1, Maria Rosaria Matarazzo1,
Francesca Costabile1, Alessio Mazzoni2, Carmela Gallo3, Genoveffa Nuzzo3,
Francesco Annunziato2, Angelo Fontana3, Antonio Leonardi1, Claudia Angelini1,
Raffaele De Palma1 ( 1Naples - Italy, 2Florence - Italy, 3Pozzuoli - Italy)
255
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
POSTER SESSION
Antigen-specific CD8 T cells in cell cycle circulate in the blood after vaccination
P062
Ambra Natalini1, Sonia Simonetti1, Antonella Folgori1, Stefania Capone1,
Alfredo Nicosia2, Angela Santoni1, Francesca Di Rosa1 ( 1Rome - Italy, 2Naples - Italy)
Role of serum amyloid P component in antifungal immune response
P063
Andrea Doni1, Raffaella Parente1, Ilaria Laface2, Elena Magrini1, Federico Colombo1,
Antonio Inforzato1, Cecilia Garlanda1, Marina Botto3, Alberto Mantovani1
( 1Rozzano - Italy, 2New York - USA, 3London - United Kingdom)
Evaluation of novel biomarkers for early detection of septic patients in Emergency room
P064
Sadaf Davoudian1, Sonia Valentino1, Roberto Leone1, Martina Molgora1,
Antonio Inforzato1, Matteo Stravalaci1, Fatemeh Asgari1, Rita Gomes1,
Achille Anselmo1, Carlo Fedeli1, Denise Comina1, Antonio Voza1, Barbara Bottazzi1,
Cecilia Garlanda1, Alberto Mantovani2 ( 1Rozzano - Italy, 2London - United Kingdom )
Functional characterization of MS4A proteins in the macrophage context
P065
Rita Silva-Gomes1, Marina Sironi1, Matteo Stravalaci 1, Alessandro Fontanini1,
Irene Mattiola 2, Cristina Cunha3, Agostinho Carvalho3, Massimo Locati1,
Maria José Oliveira4, Barbara Bottazzi1, Alberto Mantovani1 ( 1Milan - Italy, 2Berlin -
Germany, 3Braga - Portugal, 4Porto - Portugal)
CODEX®: a novel platform for spatially-resolved deep antigen profiling of single cells
P066
in tissue samples
Maria Elena Gallina, Nadya Nikulina, Jaskirat Singh, Gajalakshmi Dakshinamoorthy,
Joseph Kim, Sejal Mistry, Roya Bashier, Julia Kennedy-Darling (Menlo Park - USA)
KIR3DS1-mediated recognition of HLA-*B51: modulation of KIR3DS1 responsiveness by
P067
self HLA-B allotypes and effect on NK cell licensing
Simona Carlomagno1, Michela Falco1, Maria Bono1, Claudia Alicata2,
Lucia Garbarino1, Michela Mazzocco1, Lorenzo Moretta2, Alessandro Moretta1,
Simona Sivori1 ( 1Genoa - Italy, 3Rome - Italy)
NK cell activation mediates protection against aggressive mesothelioma and
P068
plasmacytoma in a mouse model of viral infection
Mohamed Mandour, Pyone Pyone Soe, Jean-Paul Coutelier (Brussels - Belgium)
Functional crosstalks of tumour-infiltrating iNKT cells in sporadic and IBD-associated
P069
colorectal cancer (CRC)
Claudia Burrello, Maria Rita Giuffrè, Ilaria Magagna, Fiorenzo Botti, Alberto Carrara,
Flavio Caprioli, Federica Facciotti (Milan - Italy)
265
th International Conference of translational medicine
on pathogenesis and therapy of immunomediated diseases
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019
Università degli Studi di Milano
Milan, Italy
POSTER SESSION
In melanoma patients the high frequency of circulating CCR7+ natural killer cells
P070
marks. The disease evolution and reveals a new CCL19 dependent metastatic
pathway
Costanza Maria Cristiani1, Alice Turdo2, Valeria Ventura1, Tiziana Apuzzo2,
Mariaelena Capone3, Gabriele Madonna3, Domenico Mallardo3, Cinzia Garofalo1,
Emilia Dora Giovannone1, Antonio Maria Grimaldi3, Rossana Tallerico1,
Emanuela Marcenaro4, Silvia Pesce4, Genny Del4, Valter Agosti1,
Francesco Saverio Costanzo1, Elio Gulletta1, Aroldo Rizzo2, Alessandro Moretta4,
Klas Karre5, Paolo Antonio Ascierto3, Matilde Todaro2, Ennio Carbone1 ( 1Catanzaro
- Italy, 2Palermo - Italy, 3Naples - Italy, 4Catanzaro - Italy, 5Genoa - Italy, 6Stockholm -
Sweden)
Anti-PD-1 immunotherapy modulates PD-L1 expression on neutrophil subsets and
P071
monocytes from advanced melanoma patients
Maria Rosaria Galdiero, Leonardo Cristinziano, Luca Modestino, Marilena Capone,
Gabriele Madonna, Domenico Mallardo, Stefania Loffredo, Mariantonia Braile,
Anne Lise Ferrara, Simone Marcella, Marilena Tuffanelli, Antonio Maria Grimaldi,
Ester Simeone, Paolo Antonio Ascierto, Gianni Marone (Naples - Italy)
Neutrophil extracellular DNA traps (NETs) in human thyroid cancer
P072
Leonardo Cristinziano, Luca Modestino, Mariantonia Braile, Anne Lise Ferrara,
Simone Marcella, Sara Scala, Stefania Loffredo, Gianni Marone,
Maria Rosaria Galdiero (Naples - Italy)
Identification of a new vascular marker correlating with colon cancer
P073
metastatization at distant organs
Alice Bertocchi1, Sara Carloni2, Ilaria Spadoni2, Simona Ravenda1, Giovanni Bertalot1,
Salvatore Pece1, Pier Paolo Di Fiore1, Giuseppe Viale1, Giuseppe Penna1,
Maria Rescigno1 ( 1Rozzano - Italy, 2Milan - Italy)
The interplay of the macrophage tetraspan MS4A4A with Dectin-1 and its role in NK
P074
cell-mediated resistance to metastasis
Irene Mattiola1, Federica Tomay1, Maria De Pizzol1, Rita Silva-Gomes1, Benedetta
Savino1, Tamara Gulic1, Andrea Doni1, Silvia Lonardi2, Marie-Astrid Boutet3,
Alessandra Nerviani3, Roberta Carriero1, Martina Molgora1, Matteo Stravalaci1,
Diego Morone1, Irina N. Shalova4, Yiunquin Lin4, Shubra K. Biswas4, Giovanna
Mantovani5, Marina Sironi1, Costantino Pitzalis3, William Vermi2, Barbara Bottazzi1,
Alberto Mantovani1, Massimo Locati1 ( 1Pieve Emanuele - Italy, 2Brescia
Boosting NK cell anti tumor function in vitro for therapeutic options
P075
Ester Badami, Claudia Coronnello, Floriana Barbera, Diego Paini, Pier Giulio Conaldi
(Palermo - Italy)
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