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POSTER PRESENTATION - OMICS International
15 th World Conference on
     Cosmetic Dermatology & Skin Diseases
     September 25-26, 2019 | Lisbon, Portugal

   POSTER
PRESENTATION
POSTER PRESENTATION - OMICS International
Ehsan Kamani, J Cosmo Trichol 2019, Volume 08

                                                     15th World Conference on

Cosmetic Dermatology & Skin Diseases
                              September 25-26, 2019 | Lisbon, Portugal

                                                          Application of laser in medicine (treatment and diagnosis)

                                                          L  aser is a technology used in various medical fields. After the revolution,
                                                             Penny Celine has been in the medicine of this laser, which has
                                                          revolutionized medicine I have studied and studied laser applications in
                                                          medical sciences, and I have been able to get the right information in this
                                                          area.

                                                          Biography
                                                          Ehsan Kamani was born in 1994 in Iran. I am a graduate of the field of optics and laser engineering.
                                                          I started studying and researching the use of lasers in medicine since 2014. I am mighty in the
                                                          field of laser I have an intense internal drive. I am eager to learn medicine and treat people with
                                                          passion, and the willingness to take a chance, to fail if necessary, and to start the process all over
                                                          again. I have a passion for research to be able to make life better for people affected by diseases
                                                          and it is far more important than anything to me. Working in a place nearby cancer department of
                                                          Shohada University and watching patients affected by cancer complications made me think how I
                                                          can help these people. I choose University due to the chance that has given to me with its superb
                                                          research expertise.
                                                                                                                                          E110_k@yahoo.com
          Ehsan Kamani
       Eng optic and laser, Iran

 Journal of Cosmetology & Trichology | ISSN : 2471-9323                                    Cosmetology Conference 2019                                 Volume 5

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POSTER PRESENTATION - OMICS International
Alanoud Hakami, J Cosmo Trichol 2019, Volume 08

                                                      15th World Conference on

Cosmetic Dermatology & Skin Diseases
                               September 25-26, 2019 | Lisbon, Portugal

                                                           Prevalence of autoimmune diseases among psoriatic patients in a
                                                           tertiary hospital
                                                           Background: Psoriasis is a chronic inflammatory skin condition of
                                                           unknown aetiology. It has been presumed that psoriasis is associated with
                                                           several autoimmune diseases. Data regarding the prevalence of autoimmune
                                                           diseases in psoriasis is scant. In addition, no study has yet determined the
                                                           prevalence of autoimmune diseases amongst psoriatic patients in Saudi
                                                           Arabia.
                                                           Objectives: The aim of this study is to determine the prevalence of
                                                           autoimmune diseases among psoriatic patients in a tertiary hospital,
                                                           Riyadh, Saudi Arabia. By recognizing that some psoriatic patients may have
                                                           strong links to other autoimmune diseases, the diseases can be monitored
                                                           more efficiently, diagnosed earlier, and treated more effectively.
                                                           Methodology: A cross-sectional study was conducted at King Abdulaziz
                                                           Medical City (KAMC), Riyadh, Saudi Arabia, where conventional sampling
                                                           technique was done to include all patients with psoriasis from 2016-2018,
         Alanoud Hakami                                    and the total sample was 841.
King Saud Bin Abdulaziz for Health and                     Results: 56.4% of our patients were female, and were mostly between the
            Sciences, KSA                                  ages of 31-50 years, measuring 37.1%. Only 7.4% of those with psoriasis had
                                                           a known family history. The majority of our patients did not have a comorbid
                                                           autoimmune disease. The prevalence of autoimmune diseases in descending
                                                           order was hypothyroidism 6.8%, alopecia areata 3.6%, atopic dermatitis
                                                           2.9%, hyperthyroidism 2.6%, vitiligo 1.9%, rheumatoid arthritis 1.5%, SLE,
                                                           0.8%, celiac disease 0.6% and Crohn’s disease 0.5%. Hypothyroidism was the
                                                           only disease with a statistically significant association p
POSTER PRESENTATION - OMICS International
Sheida Naderi-Azad, J Cosmo Trichol 2019, Volume 08

                                                      15th World Conference on

Cosmetic Dermatology & Skin Diseases
                               September 25-26, 2019 | Lisbon, Portugal

                                                           The potential of BRAF-targeted therapy combined with
                                                           immunotherapy in melanoma

                                                           S  tatement of the Problem: Advanced melanoma involves metastasis
                                                              to distant sites and is associated with poor long-term survival
                                                           (Fisher et al., 2012). Current treatment options for melanoma include
                                                           interleukin 2, targeted therapy (BRAFi, MEKi) and immunotherapy
                                                           (CTLA4 antibody, PD1/PDL1 antibody). While targeted therapeutics
                                                           can successfully block oncogenic signaling with high clinical response,
                                                           they result in high relapse rates due to acquired resistance. Furthermore,
                                                           while immunotherapeutics can induce durable responses, they have
                                                           lower response rates due to immune evasion and suppression of effector
                                                           function in tumour microenvironment. The purpose of this study is to
                                                           discuss the potential for combining immunotherapy and targeted therapy
                                                           with the goal of achieving high response rates with prolonged duration.
                                                           Methodology & Theoretical Orientation: To obtain these results, various
                                                           search terms such as immunotherapy and targeted therapy were utilized.
                                                           Furthermore, the articles were selected based on recency of publication as
       Sheida Naderi-Azad                                  well as depth of detail regarding the specific immunologic mechanisms by
University of Toronto Medical School,                      which combination therapies exert their effects. Findings: The results show
                                                           that potential mechanisms of combinatorial activity of immunotherapy
                Canada
                                                           and targeted therapy include increasing antigen presentation, as well as
                                                           improved lymphocyte homing and function. Yet it is important to note
                                                           that long-term consequences of combinatorial therapeutics are uncertain,
                                                           and clinical trials of combinations have resulted in adverse effects such
                                                           as hepatotoxicity and intestinal perforation. Conclusion & Significance:
                                                           Altogether, these results indicate a potential combination for BRAF-targeted
                                                           therapy and immunotherapy in achieving long-term durable responses.
                                                           Biography
                                                           Sheida Naderi-Azad has completed her Bachelor of Science in Microbial and Environmental
                                                           Pathophysiology from University of British Columbia and is currently an MD Candidate at the
                                                           University of Toronto Faculty of Medicine. She has an expertise in immunodermatology, with a
                                                           deep interest in melanoma immunotherapeutics, primary immunodeficiency diseases such as
                                                           atopic dermatitis, and autoimmune conditions such as psoriasis. She has most recently completed
                                                           a summer studentship at the Melanoma Clinic, Massachusetts General Hospital. She has had
                                                           numerous published articles and presentations on melanoma therapeutics, anti-inflammatory
                                                           conditions and dermatologic comorbidities such as mood disorders.

                                                                                                                          sheida.naderi@mail.utoronto.ca

  Journal of Cosmetology & Trichology | ISSN : 2471-9323                                  Cosmetology Conference 2019                             Volume 5

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POSTER PRESENTATION - OMICS International
15 th World Conference on
   Cosmetic Dermatology & Skin Diseases
   September 25-26, 2019 | Lisbon, Portugal

E-POSTERS
POSTER PRESENTATION - OMICS International
Lorenzo Martini, J Cosmo Trichol 2019, Volume 08

                                                     15th World Conference on

Cosmetic Dermatology & Skin Diseases
                              September 25-26, 2019 | Lisbon, Portugal

                                                          Easier method to defeat Psoriasis laepraformis by using plants
                                                          native to the same places where this disease is endemic

                                                          O    ne of the latest steps of the psoriatic syndromes is the psoriasis
                                                               laepraformis. The AA, unscrupulously tend to assert that it is always
                                                          better to follow the historiographical path that drives to a determined cure
                                                          that had been well established and tested since centuries, even if the original
                                                          ideas were exceptional and results were sometimes not quite satisfactory.
                                                          Aldous Huxley recited “Technological progress has merely provided us with
                                                          more efficient means for going backwards.” And thus the AA has preferred
                                                          to go back to investigate the very history of Psoriasis those in very ancient
                                                          times was confounded with Leprosy.
                                                          Leprosy is an ancient, chronic granulomatous disease caused by acid fast
                                                          bacilli, the Gerhard Armauer Hansen’s bacilli spirilli, affecting all age
                                                          groups and has no sex predilection. Usually the disease presents with hypo
                                                          pigmented patches, nodules and plaques with or without loss of sensations
                                                          and thickening of nerves. Leprosy has a wide range of presentation which can
                                                          mimic various other\differential diagnosis is so wide that one has to exclude
           Lorenzo Martini                                wide variety of dermatological diseases before stamping it to be leprosy as
                Italy                                     stigma is still associated to it. So, since the psoriasis is one of a plentitude
                                                          of illnesses that does not know therapeutic results at all, notwithstanding
                                                          ultra-modern and most sophisticated shamans and opinion-makers give
                                                          false hope and mislead, is resistant to every type of medication, we have
                                                          observed what ancient physicians employed to combat this malaise in the
                                                          lands where the illness was endemic.
                                                                                                                        Lorenzo.martini@unisi.it

 Journal of Cosmetology & Trichology | ISSN : 2471-9323                             Cosmetology Conference 2019                        Volume 5

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POSTER PRESENTATION - OMICS International
Kacey HAU, J Cosmo Trichol 2019, Volume 08

                                                     15th World Conference on

Cosmetic Dermatology & Skin Diseases
                              September 25-26, 2019 | Lisbon, Portugal
                                                          Surgical adverse events and incidence rate in bidirectional barb
                                                          suspension thread surgery
                                                          Introduction: Barb suspension surgery is getting popular as a
                                                          supplementary choice for facial contouring and reshaping. Compared with
                                                          formal face lifting, barb suspension provides a safer, minimally invasive and
                                                          office-based surgical procedure. However, barb suspension surgery do have
                                                          certain risks due to the invasive nature.
                                                          Objective: We would like to evaluate the incidence of adverse events after
                                                          thread suspension surgery. Through this retrospective analysis, we would
                                                          like to standardize the possible adverse events to facilitate future reporting
                                                          and prevention strategies.
                                                          Methods: This is a single centre retrospective cohort study on the surgical
                                                          outcomes. A collection of 200 pairs of thread used in the period of 2017-
                                                          2019 (two years). The patients were followed up one week, two weeks and
                                                          four weeks after surgery. The adverse events are stratified according to
                                                          defined categories. Photos were taken for documentation after patients’
                                                          consent.

          Kacey HAU                                       Results: the incidence of adverse event rate in the first week is 13.5%.
     Dermatologist, Hong Kong
                                                          It drops in the first 4 weeks, 9.6% at week 2, and 5.5% at week 4. The
                                                          reported adverse events which persist after 4 weeks(number in brackets)
                                                          include headache(0), redness(0), swelling and bruising(0), persistent
                                                          surgical site pain(0), surgical site infection(1), asymmetry(0), palpability
                                                          of threads(0), early recurrence(0), protrusion and extrusion(5), injury
                                                          of the local anatomical parts like parotid gland(1), post-inflammatory
                                                          hyperpigmentation(0), bunching, pleating and dimpling(5).
                                                          Discussion and onclusion: Both patient factor, operator factor, material
                                                          and surgical field can contribute to the incidence. Barb suspension thread
                                                          surgery is a relatively safe procedure. With careful selection of candidates,
                                                          well-planned surgery, and respect to the sterility of surgical field and
                                                          individual anatomical structures, majority of the incidents are avoidable.
                                                          Clear post-operative care instruction and prompt intervention should
                                                          issues arise are essential.
                                                          Biography
                                                          Kacey Hau is a dermatology specialist in private practice. He is the global trainer in thread
                                                          suspension surgery, botulinum toxin and minimally invasive surgery. He publishes in the literature,
                                                          poster presentation and book chapters on thread surgery. He is the members of the committees of
                                                          related advisory boards, expert panels and scientific board.
                                                                                                                            drhau@perfectskinsurgery.com

 Journal of Cosmetology & Trichology | ISSN : 2471-9323                                   Cosmetology Conference 2019                               Volume 5

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POSTER PRESENTATION - OMICS International
15 th World Conference on
    Cosmetic Dermatology & Skin Diseases
    September 25-26, 2019 | Lisbon, Portugal

ACCEPTED
ABSTRACTS
POSTER PRESENTATION - OMICS International
J Cosmo Trichol 2019, Volume 08

                                                     15th World Conference on

Cosmetic Dermatology & Skin Diseases
                              September 25-26, 2019 | Lisbon, Portugal

 Restoration of pigmentation by hot incubated autologous non cultured keratinocyte
 melanocyte transplant in patients of stable and refractory focal Vitiligo
 Prachi Agrawal,
 MD Dermatologist, India

 V    itiligo affects about 2% of the world population and cause psychological distress, low self-esteem and
      suicidal tendencies. Despite the availability of various medical treatments, a large percentage fails to
 achieve satisfactory results. In such cases surgical treatment may help restore pigmentation. In recent years,
 cellular transplantation such as the non-cultured melanocyte-keratinocyte suspension has gained popularity
 because of minimal technical complexity, superior aesthetic results and requirement of only a small donor
 area. Very few studies regarding the effectiveness of this technique exist in the literature. We hereby report
 our experience with this technique.
 Objectives: To determine the efficacy of transplantation of autologous non-cultured keratinocytes melanocytes
 in stable vitiligo and to obtain a successful uniform repigmentation and observe for side effects; if any.
 Materials and methods: Ten patients with stable vitiligo were included and duration of our study was 6
 months. Superficial split thickness skin grafts taken from donor site, transferred to 0.25% trypsin-EDTA,
 incubated for 40 minutes at 37ºC followed by dermal epidermal separation in a medium of autologous
 plasma, then centrifuged and applied to a dermabraded depigmented skin area and collagen dressing placed.
 The patients were observed over every 15 days, for following 6 months and the photographs were taken. We
 maintained the patient on NBUVB, along with topical corticosteroids on and off for the 6 months following
 surgery.
 Results: Onset of pigmentation observed earliest at 3 weeks post-operatively; however, in few, it was delayed
 up to 6 weeks. Homogenous repigmentation achieved after 6 months was uniform and matches well with
 surrounding skin.
 Discussion: The hot incubated autologous non cultured keratinocyte melanocyte transplant technique is
 simple, yet effective cell based therapy in refractory cases of stable vitiligo; the main advantage being that
 larger areas can be treated with a small donor site in a comparatively short period of time.

 Journal of Cosmetology & Trichology | ISSN : 2471-9323              Cosmetology Conference 2019                          Volume 5

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J Cosmo Trichol 2019, Volume 08

                                                     15th World Conference on

Cosmetic Dermatology & Skin Diseases
                              September 25-26, 2019 | Lisbon, Portugal

 Scalp micro pigmentation as an alternative to hair transplant surgery
 Seepika Jaiswal,
 MD Dermatologist, India

 Objective: Introduction-While SMP does realistically mimic hair follicles, it does not replace or restore hair.
 A medical hair line tattoo is strictly cosmetic, but it will give the recipient the appearance of a freshly shaved
 head or, in the case of diffuse baldness, it camouflages the scalp within the remaining hair, eliminating the
 contrast of a bare scalp peeking through thinning hair.
 Materials and methods: SMP requires needles and medical grade pigment. Although similar, micro
 pigmentation is performed slightly differently than a standard body tattoo. For example, the diameter of the
 needle used to apply pigment is much smaller to more closely mimic the appearance of hair. The pigment
 used is also different than pigments used in standard tattoos as they are customized to match the recipient's
 hair.
 A surgical hair transplant requires that the patients’ scalp be receptive to new follicles and, of course, the
 patient must also have a viable donor site from which to remove healthy hair follicles for transplant. SMP,
 on the other hand, can be performed on a fully or partially bald scalp without shaving or the risk of rejection,
 provided that your procedure is completed by an experienced and skilled specialist. SMP boasts a 100%
 success rate.
 Results: Non-surgical SMP will slowly fill in and define, your existing hairline with a custom-selected
 pigment mix specially designed to mimic your hair’s natural growth patterns as well as your hair’s various
 shades and colors.
 Conclusion: SMP is typically completed in 2 non-consecutive sessions. The spacing of sessions helps
 gradually introduce subtle changes into the appearance of the recipient over the course of several weeks.
 While the healing period required for a surgical hair transplant is not excessive, a medical hairline tattoo
 requires zero downtime whatsoever.

 Journal of Cosmetology & Trichology | ISSN : 2471-9323              Cosmetology Conference 2019                          Volume 5

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J Cosmo Trichol 2019, Volume 08

                                                     15th World Conference on

Cosmetic Dermatology & Skin Diseases
                              September 25-26, 2019 | Lisbon, Portugal

 The visualization of hair follicles by means of Ultrasound scanner to reduce damage for hair
 follicles during FUE (follicular unit extraction)
 WooKoung Lee¹, MD, HakKyu Lee2
 1
  Root Hair Transplantation Center, 2Gangnam Theme Dermatologic Clinic, South Korea

 FUE has many advantages but definitely have disadvantages as well. One of them includes potential for high
 follicle transection rate. There is a difference in angle between hair and follicle. We want to use ultrasound as
 a way to overcome the difference. In addition, we will present a method to make the FUE more easily using
 our sensor.

Figure 1: The scanned image is saved in a computer program.

                                                                                Figure 3: The follicle is hypoechoic as seen here

Figure 2: Rotated 90 degrees to help understand

                                                                                Figure 4: Sensors used in ultrasound-guided FUE

 Journal of Cosmetology & Trichology | ISSN : 2471-9323              Cosmetology Conference 2019                          Volume 5

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J Cosmo Trichol 2019, Volume 08

                                                     15th World Conference on

Cosmetic Dermatology & Skin Diseases
                              September 25-26, 2019 | Lisbon, Portugal

 Type I leucocyte adhesion deficiency in Yemenian family managed with appropriate
 treatment: A case series
 Ezeldeen Alsorori3, Carmen Cantisani1, Ahmad Faiq Naqeshbandi1, Mohamad Goldust2, Salvatore Lampitelli1,
 Franca Cantoresi1,
 1
  U.O.C Dermatologia, Dipartimento di scienze mediche, Policlinico Umberto , Italia
 2
  Mazandaran University of medical sciences, Iran
 3
  University of Science and technology hospital Sanaa, Yemen

 P    rimary immunodeficiencies(PIDS) are rare,inherited diseases, characterized by altered function or
      absence of immune cells. Among them is leukocyte adhesion deficiency type I (LAD-I), an autosomal
 recessive disorder characterized by primary immunodeficiency, caused by mutations in the ITGB2 gene which
 produces inability of leucocytes to migrate towards the area of inflammation and is associated with recurrent
 life-threatening bacterial and fungal infections. Pyoderma gangrenosum(PG) is an uncommon noninfectious
 neutrophilic dermatosis, characterized by recurrent, necrotic ulcers. It is a diagnosis of exclusion and can be
 challenging and its management is empirical, with local(topical tacrolimus or intralesional triamcinolone) or
 systemic immunosuppressive therapy (oral or intravenous glucocorticoids, sulfasalazine, especially in cases
 associated with crohn’s disease, cyclosporine and, recently, anti-TNF drugs such as Infliximab, Etanercept,
 Adalimumab). Though skin ulcerations are common, predominant clinical presentation as PG can often
 mimic other diseases. It is unusual in children even more in LAD-I. Here we present a Yemenian family
 with LAD-I from consanguineous relatives. All patients had history of chronic recurrent skin ulcerations
 without any bleeding tendency, associated with persistent neutrophilia and requiring steroids and antibiotics.
 There was no history of delayed cord separation and the condition was initially diagnosed as epidermolysis
 bullosa, but successively as PG. LAD-I should be kept in mind while evaluating patients with PG especially
 in children with persistent neutrophilia in the absence of other rheumatological disorders. Its diagnosis is
 extremely important from the management perspective, as treating these patients without adequate antibiotic
 cover may be fatal, as happened to one of our patient, and these patients often require hematopoietic stem
 cell transplantation for permanent cure. Therefore, genetic counseling especially in population with high
 consanguinity is mandatory.

 Journal of Cosmetology & Trichology | ISSN : 2471-9323              Cosmetology Conference 2019                          Volume 5

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J Cosmo Trichol 2019, Volume 08

                                                     15th World Conference on

Cosmetic Dermatology & Skin Diseases
                              September 25-26, 2019 | Lisbon, Portugal

 Combined use of topical imiquimod and 5-fluorouracil in the management of in-transit
 cutaneous melanoma: A Case Report and Literature Review
 Sheida Naderi-Azad1, Marisa Ponzo2
 1
  University of Toronto Medical School, Canada
 2
  University of British Columbia Faculty of Medicine, Canada

 S   tatement of the Problem: While there are numerous therapeutic options available for in-transit cutaneous
     melanoma, the treatments are often unsuccessful due to suboptimal response rates. This motivates the use
 of combination therapies such as imiquimod and 5-fluorouracil to increase therapeutic efficacy. Imiquimod
 and 5-fluorouracil have distinct mechanisms of action, with imiquimod binding to toll-like receptor 7 and 8
 on leukocytes and 5-FU inhibiting thymidylate synthase and inhibiting DNA synthesis. The purpose of this
 case report is to describe the course of an 87-year-old female with an 8-year history of cutaneous melanoma.
 Findings: The patient was initially managed with a wide local excision of the right shin lesion, as well as
 a split-thickness graft. She was further treated with a combination of 5% topical imiquimod cream and 5%
 5-fluorouracil cream. There was complete clearance within 23 months, and the patient has been disease-
 free since. Conclusion & Significance: Given the patient’s complete clearance and disease-free state since
 treatment, we postulate that imiquimod and 5-FU’s synergistic mechanisms of action provide a valuable
 potential for targeting in-transit cutaneous melanoma in patients.

 Journal of Cosmetology & Trichology | ISSN : 2471-9323              Cosmetology Conference 2019                          Volume 5

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J Cosmo Trichol 2019, Volume 08

                                                     15th World Conference on

Cosmetic Dermatology & Skin Diseases
                              September 25-26, 2019 | Lisbon, Portugal

 Novel psoriasis therapeutics: examining the anti-inflammatory utility of anti-anxiolytic
 medications
 Sheida Naderi-Azad
 University of Toronto Medical School, Canada

 S    tatement of the Problem: Psoriasis is a debilitating autoimmune disease defined by erythematous,
      pruritic, and scaly plaques. Yet, this disease also has numerous extracutaneous associations including
 depression, heart disease, arthritis, and inflammatory bowel disease. The combination of physical and mental
 manifestations of psoriasis can be explained, respectively, by inflammatory cytokines that act on skin cells
 to create scaly patches and brain cells to alter one’s mental state. The purpose of this study is to discuss
 the novel use of anti-anxiolytic medications to address psoriasis therapeutics. Methodology & Theoretical
 Orientation: To obtain these results, various search terms such as psoriasis and anti-anxiolytics were utilized.
 Furthermore, the articles were selected based on recency of publication as well as depth of detail regarding
 the specific immunologic mechanisms by which anti- psychotics exert their therapeutic effects. Findings:
 The results show that educing anxiety can reduce the release of stress compounds, thus reducing body’s
 inflammatory reaction. Specifically, stress signals such as CRH and substance P contribute to the release
 of inflammatory cytokines such as TNF-α and interleukins. Conclusion & Significance: Psoriasis provides
 evidence for the connection between the psychiatric symptoms caused by changes in the brain and cutaneous
 symptoms caused by changes in the skin. The bidirectionality of these interactions is used to create a novel
 use for anti-anxiolytic medications in treating psoriatic symptoms.

 Journal of Cosmetology & Trichology | ISSN : 2471-9323              Cosmetology Conference 2019                          Volume 5

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J Cosmo Trichol 2019, Volume 08

                                                     15th World Conference on

Cosmetic Dermatology & Skin Diseases
                              September 25-26, 2019 | Lisbon, Portugal

 Examining the role of inflammasomes in psoriasis, atopic dermatitis, and contact dermatitis:
 A Review
 Sheida Naderi-Azad
 University of Toronto Medical School, Canada

 S    tatement of the Problem: Inflammasomes are intracellular multiprotein complexes that comprise part of
      the innate immune response. They are composed of three elements; the pattern recognition receptor, an
 adaptor protein, and a caspase-1 enzyme that results in production of pro-inflammatory cytokines (Dunn et
 al., 2012). Inflammasome disorders have been linked to an increasing number of diseases. Autoinflammatory
 diseases refer to disorders in which local factors lead to the activation of innate immune cells, causing
 tissue damage in the absence of autoantigens and autoantibodies. The purpose of this review is to discuss
 the involvement of inflammasomes in inflammatory skin conditions such as psoriasis, atopic and contact
 dermatitis by the production of the interleukin-1 (IL-1) family of cytokines. Findings: The results for contact
 dermatitis show that inflammasome-dependent secretion of IL-1B, IL-18 and IL-1R cytokines results in T-cell
 inflammation in sensitized individuals (Li and Zhong 2014, Watanabe et al., 2007, Coehlo de Sa and Nato
 2016). Inflammasomes have also been shown to contribute to AD by upregulating the epidermal expression
 of IL-1B and IL-1RA (Machura et al., 2018, Hay et al., 2012, Kezic et al., 2012). IL-1β and IL-18 also play
 a key role in psoriasis, as indicated by the involvement of NLRP1, NLRP3 and CARD8 polymorphisms,
 as well as upregulation of caspase-1 and AIM-2 for cytokine production (Carlstrom et al., 2012, Ekman et
 al., 2014, Johansen et al., 2007, Dombrowski et al., 2011). Conclusion & Significance: The inflammasome-
 mediated secretion of IL-1 family cytokines in contact dermatitis, atopic dermatitis and psoriasis implicates
 the potential role of caspase, NLR and IL-targeted therapy for treatment of inflammatory skin conditions.

 Journal of Cosmetology & Trichology | ISSN : 2471-9323              Cosmetology Conference 2019                          Volume 5

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J Cosmo Trichol 2019, Volume 08

                                                     15th World Conference on

Cosmetic Dermatology & Skin Diseases
                              September 25-26, 2019 | Lisbon, Portugal

 What wound care specialists should know about Pyoderma Gangrenosum
 Sheida Naderi-Azad
 University of Toronto Medical School, Canada

 S   tatement of the Problem: Pyoderma gangrenosum (PG) is a rare, destructive neutrophilic dermatosis
     characterized by a progressive, necrotizing process. The classic pyoderma involves a full-thickness
 ulcer with blue undermining borders. Patients exhibit “pathergy” with the appearance of new lesions after
 local trauma such as surgical procedures, debridement, and biopsy, thus suggesting altered inflammatory
 response (Soncini et al., 2016). The treatment of PG involves both systemic therapy such as corticosteroids
 and antibiotics, and topical therapy like wound dressings and compression therapy. The purpose of this
 review is to discuss the benefits of wound dressing and compression therapy in treating acute wounds from
 PG. Methodology & Theoretical Orientation: To obtain these results, search terms including “pyoderma
 gangrenosum”, “wound dressing” and “compression therapy” were utilized. Furthermore, the articles were
 selected based on recency of publication as well as depth of detail regarding the specific PG types they help
 target. Findings: The results show that numerous dressings are used to target each subtype including films
 for superficial skin disruption, hydrogels for dry eschars, absorptive alginates for exudates, hydrocolloids
 for granulating wounds, and silver iodide for colonized wounds. In addition, compression therapy is used
 for healing ulcers and preventing recurrent ulcers. Conclusion & Significance: The results of this study will
 be used to enhance wound care in PG by individualizing each dressing depending on the nature of the PG
 wound. The use of both wound dressings and compression therapy will facilitate improved healing of this
 debilitating dermatosis.

 Journal of Cosmetology & Trichology | ISSN : 2471-9323              Cosmetology Conference 2019                          Volume 5

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