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15 th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal POSTER PRESENTATION
Ehsan Kamani, J Cosmo Trichol 2019, Volume 08 15th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal Application of laser in medicine (treatment and diagnosis) L aser is a technology used in various medical fields. After the revolution, Penny Celine has been in the medicine of this laser, which has revolutionized medicine I have studied and studied laser applications in medical sciences, and I have been able to get the right information in this area. Biography Ehsan Kamani was born in 1994 in Iran. I am a graduate of the field of optics and laser engineering. I started studying and researching the use of lasers in medicine since 2014. I am mighty in the field of laser I have an intense internal drive. I am eager to learn medicine and treat people with passion, and the willingness to take a chance, to fail if necessary, and to start the process all over again. I have a passion for research to be able to make life better for people affected by diseases and it is far more important than anything to me. Working in a place nearby cancer department of Shohada University and watching patients affected by cancer complications made me think how I can help these people. I choose University due to the chance that has given to me with its superb research expertise. E110_k@yahoo.com Ehsan Kamani Eng optic and laser, Iran Journal of Cosmetology & Trichology | ISSN : 2471-9323 Cosmetology Conference 2019 Volume 5 Page 34
Alanoud Hakami, J Cosmo Trichol 2019, Volume 08 15th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal Prevalence of autoimmune diseases among psoriatic patients in a tertiary hospital Background: Psoriasis is a chronic inflammatory skin condition of unknown aetiology. It has been presumed that psoriasis is associated with several autoimmune diseases. Data regarding the prevalence of autoimmune diseases in psoriasis is scant. In addition, no study has yet determined the prevalence of autoimmune diseases amongst psoriatic patients in Saudi Arabia. Objectives: The aim of this study is to determine the prevalence of autoimmune diseases among psoriatic patients in a tertiary hospital, Riyadh, Saudi Arabia. By recognizing that some psoriatic patients may have strong links to other autoimmune diseases, the diseases can be monitored more efficiently, diagnosed earlier, and treated more effectively. Methodology: A cross-sectional study was conducted at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia, where conventional sampling technique was done to include all patients with psoriasis from 2016-2018, Alanoud Hakami and the total sample was 841. King Saud Bin Abdulaziz for Health and Results: 56.4% of our patients were female, and were mostly between the Sciences, KSA ages of 31-50 years, measuring 37.1%. Only 7.4% of those with psoriasis had a known family history. The majority of our patients did not have a comorbid autoimmune disease. The prevalence of autoimmune diseases in descending order was hypothyroidism 6.8%, alopecia areata 3.6%, atopic dermatitis 2.9%, hyperthyroidism 2.6%, vitiligo 1.9%, rheumatoid arthritis 1.5%, SLE, 0.8%, celiac disease 0.6% and Crohn’s disease 0.5%. Hypothyroidism was the only disease with a statistically significant association p
Sheida Naderi-Azad, J Cosmo Trichol 2019, Volume 08 15th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal The potential of BRAF-targeted therapy combined with immunotherapy in melanoma S tatement of the Problem: Advanced melanoma involves metastasis to distant sites and is associated with poor long-term survival (Fisher et al., 2012). Current treatment options for melanoma include interleukin 2, targeted therapy (BRAFi, MEKi) and immunotherapy (CTLA4 antibody, PD1/PDL1 antibody). While targeted therapeutics can successfully block oncogenic signaling with high clinical response, they result in high relapse rates due to acquired resistance. Furthermore, while immunotherapeutics can induce durable responses, they have lower response rates due to immune evasion and suppression of effector function in tumour microenvironment. The purpose of this study is to discuss the potential for combining immunotherapy and targeted therapy with the goal of achieving high response rates with prolonged duration. Methodology & Theoretical Orientation: To obtain these results, various search terms such as immunotherapy and targeted therapy were utilized. Furthermore, the articles were selected based on recency of publication as Sheida Naderi-Azad well as depth of detail regarding the specific immunologic mechanisms by University of Toronto Medical School, which combination therapies exert their effects. Findings: The results show that potential mechanisms of combinatorial activity of immunotherapy Canada and targeted therapy include increasing antigen presentation, as well as improved lymphocyte homing and function. Yet it is important to note that long-term consequences of combinatorial therapeutics are uncertain, and clinical trials of combinations have resulted in adverse effects such as hepatotoxicity and intestinal perforation. Conclusion & Significance: Altogether, these results indicate a potential combination for BRAF-targeted therapy and immunotherapy in achieving long-term durable responses. Biography Sheida Naderi-Azad has completed her Bachelor of Science in Microbial and Environmental Pathophysiology from University of British Columbia and is currently an MD Candidate at the University of Toronto Faculty of Medicine. She has an expertise in immunodermatology, with a deep interest in melanoma immunotherapeutics, primary immunodeficiency diseases such as atopic dermatitis, and autoimmune conditions such as psoriasis. She has most recently completed a summer studentship at the Melanoma Clinic, Massachusetts General Hospital. She has had numerous published articles and presentations on melanoma therapeutics, anti-inflammatory conditions and dermatologic comorbidities such as mood disorders. sheida.naderi@mail.utoronto.ca Journal of Cosmetology & Trichology | ISSN : 2471-9323 Cosmetology Conference 2019 Volume 5 Page 36
15 th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal E-POSTERS
Lorenzo Martini, J Cosmo Trichol 2019, Volume 08 15th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal Easier method to defeat Psoriasis laepraformis by using plants native to the same places where this disease is endemic O ne of the latest steps of the psoriatic syndromes is the psoriasis laepraformis. The AA, unscrupulously tend to assert that it is always better to follow the historiographical path that drives to a determined cure that had been well established and tested since centuries, even if the original ideas were exceptional and results were sometimes not quite satisfactory. Aldous Huxley recited “Technological progress has merely provided us with more efficient means for going backwards.” And thus the AA has preferred to go back to investigate the very history of Psoriasis those in very ancient times was confounded with Leprosy. Leprosy is an ancient, chronic granulomatous disease caused by acid fast bacilli, the Gerhard Armauer Hansen’s bacilli spirilli, affecting all age groups and has no sex predilection. Usually the disease presents with hypo pigmented patches, nodules and plaques with or without loss of sensations and thickening of nerves. Leprosy has a wide range of presentation which can mimic various other\differential diagnosis is so wide that one has to exclude Lorenzo Martini wide variety of dermatological diseases before stamping it to be leprosy as Italy stigma is still associated to it. So, since the psoriasis is one of a plentitude of illnesses that does not know therapeutic results at all, notwithstanding ultra-modern and most sophisticated shamans and opinion-makers give false hope and mislead, is resistant to every type of medication, we have observed what ancient physicians employed to combat this malaise in the lands where the illness was endemic. Lorenzo.martini@unisi.it Journal of Cosmetology & Trichology | ISSN : 2471-9323 Cosmetology Conference 2019 Volume 5 Page 38
Kacey HAU, J Cosmo Trichol 2019, Volume 08 15th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal Surgical adverse events and incidence rate in bidirectional barb suspension thread surgery Introduction: Barb suspension surgery is getting popular as a supplementary choice for facial contouring and reshaping. Compared with formal face lifting, barb suspension provides a safer, minimally invasive and office-based surgical procedure. However, barb suspension surgery do have certain risks due to the invasive nature. Objective: We would like to evaluate the incidence of adverse events after thread suspension surgery. Through this retrospective analysis, we would like to standardize the possible adverse events to facilitate future reporting and prevention strategies. Methods: This is a single centre retrospective cohort study on the surgical outcomes. A collection of 200 pairs of thread used in the period of 2017- 2019 (two years). The patients were followed up one week, two weeks and four weeks after surgery. The adverse events are stratified according to defined categories. Photos were taken for documentation after patients’ consent. Kacey HAU Results: the incidence of adverse event rate in the first week is 13.5%. Dermatologist, Hong Kong It drops in the first 4 weeks, 9.6% at week 2, and 5.5% at week 4. The reported adverse events which persist after 4 weeks(number in brackets) include headache(0), redness(0), swelling and bruising(0), persistent surgical site pain(0), surgical site infection(1), asymmetry(0), palpability of threads(0), early recurrence(0), protrusion and extrusion(5), injury of the local anatomical parts like parotid gland(1), post-inflammatory hyperpigmentation(0), bunching, pleating and dimpling(5). Discussion and onclusion: Both patient factor, operator factor, material and surgical field can contribute to the incidence. Barb suspension thread surgery is a relatively safe procedure. With careful selection of candidates, well-planned surgery, and respect to the sterility of surgical field and individual anatomical structures, majority of the incidents are avoidable. Clear post-operative care instruction and prompt intervention should issues arise are essential. Biography Kacey Hau is a dermatology specialist in private practice. He is the global trainer in thread suspension surgery, botulinum toxin and minimally invasive surgery. He publishes in the literature, poster presentation and book chapters on thread surgery. He is the members of the committees of related advisory boards, expert panels and scientific board. drhau@perfectskinsurgery.com Journal of Cosmetology & Trichology | ISSN : 2471-9323 Cosmetology Conference 2019 Volume 5 Page 39
15 th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal ACCEPTED ABSTRACTS
J Cosmo Trichol 2019, Volume 08 15th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal Restoration of pigmentation by hot incubated autologous non cultured keratinocyte melanocyte transplant in patients of stable and refractory focal Vitiligo Prachi Agrawal, MD Dermatologist, India V itiligo affects about 2% of the world population and cause psychological distress, low self-esteem and suicidal tendencies. Despite the availability of various medical treatments, a large percentage fails to achieve satisfactory results. In such cases surgical treatment may help restore pigmentation. In recent years, cellular transplantation such as the non-cultured melanocyte-keratinocyte suspension has gained popularity because of minimal technical complexity, superior aesthetic results and requirement of only a small donor area. Very few studies regarding the effectiveness of this technique exist in the literature. We hereby report our experience with this technique. Objectives: To determine the efficacy of transplantation of autologous non-cultured keratinocytes melanocytes in stable vitiligo and to obtain a successful uniform repigmentation and observe for side effects; if any. Materials and methods: Ten patients with stable vitiligo were included and duration of our study was 6 months. Superficial split thickness skin grafts taken from donor site, transferred to 0.25% trypsin-EDTA, incubated for 40 minutes at 37ºC followed by dermal epidermal separation in a medium of autologous plasma, then centrifuged and applied to a dermabraded depigmented skin area and collagen dressing placed. The patients were observed over every 15 days, for following 6 months and the photographs were taken. We maintained the patient on NBUVB, along with topical corticosteroids on and off for the 6 months following surgery. Results: Onset of pigmentation observed earliest at 3 weeks post-operatively; however, in few, it was delayed up to 6 weeks. Homogenous repigmentation achieved after 6 months was uniform and matches well with surrounding skin. Discussion: The hot incubated autologous non cultured keratinocyte melanocyte transplant technique is simple, yet effective cell based therapy in refractory cases of stable vitiligo; the main advantage being that larger areas can be treated with a small donor site in a comparatively short period of time. Journal of Cosmetology & Trichology | ISSN : 2471-9323 Cosmetology Conference 2019 Volume 5 Page 42
J Cosmo Trichol 2019, Volume 08 15th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal Scalp micro pigmentation as an alternative to hair transplant surgery Seepika Jaiswal, MD Dermatologist, India Objective: Introduction-While SMP does realistically mimic hair follicles, it does not replace or restore hair. A medical hair line tattoo is strictly cosmetic, but it will give the recipient the appearance of a freshly shaved head or, in the case of diffuse baldness, it camouflages the scalp within the remaining hair, eliminating the contrast of a bare scalp peeking through thinning hair. Materials and methods: SMP requires needles and medical grade pigment. Although similar, micro pigmentation is performed slightly differently than a standard body tattoo. For example, the diameter of the needle used to apply pigment is much smaller to more closely mimic the appearance of hair. The pigment used is also different than pigments used in standard tattoos as they are customized to match the recipient's hair. A surgical hair transplant requires that the patients’ scalp be receptive to new follicles and, of course, the patient must also have a viable donor site from which to remove healthy hair follicles for transplant. SMP, on the other hand, can be performed on a fully or partially bald scalp without shaving or the risk of rejection, provided that your procedure is completed by an experienced and skilled specialist. SMP boasts a 100% success rate. Results: Non-surgical SMP will slowly fill in and define, your existing hairline with a custom-selected pigment mix specially designed to mimic your hair’s natural growth patterns as well as your hair’s various shades and colors. Conclusion: SMP is typically completed in 2 non-consecutive sessions. The spacing of sessions helps gradually introduce subtle changes into the appearance of the recipient over the course of several weeks. While the healing period required for a surgical hair transplant is not excessive, a medical hairline tattoo requires zero downtime whatsoever. Journal of Cosmetology & Trichology | ISSN : 2471-9323 Cosmetology Conference 2019 Volume 5 Page 43
J Cosmo Trichol 2019, Volume 08 15th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal The visualization of hair follicles by means of Ultrasound scanner to reduce damage for hair follicles during FUE (follicular unit extraction) WooKoung Lee¹, MD, HakKyu Lee2 1 Root Hair Transplantation Center, 2Gangnam Theme Dermatologic Clinic, South Korea FUE has many advantages but definitely have disadvantages as well. One of them includes potential for high follicle transection rate. There is a difference in angle between hair and follicle. We want to use ultrasound as a way to overcome the difference. In addition, we will present a method to make the FUE more easily using our sensor. Figure 1: The scanned image is saved in a computer program. Figure 3: The follicle is hypoechoic as seen here Figure 2: Rotated 90 degrees to help understand Figure 4: Sensors used in ultrasound-guided FUE Journal of Cosmetology & Trichology | ISSN : 2471-9323 Cosmetology Conference 2019 Volume 5 Page 44
J Cosmo Trichol 2019, Volume 08 15th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal Type I leucocyte adhesion deficiency in Yemenian family managed with appropriate treatment: A case series Ezeldeen Alsorori3, Carmen Cantisani1, Ahmad Faiq Naqeshbandi1, Mohamad Goldust2, Salvatore Lampitelli1, Franca Cantoresi1, 1 U.O.C Dermatologia, Dipartimento di scienze mediche, Policlinico Umberto , Italia 2 Mazandaran University of medical sciences, Iran 3 University of Science and technology hospital Sanaa, Yemen P rimary immunodeficiencies(PIDS) are rare,inherited diseases, characterized by altered function or absence of immune cells. Among them is leukocyte adhesion deficiency type I (LAD-I), an autosomal recessive disorder characterized by primary immunodeficiency, caused by mutations in the ITGB2 gene which produces inability of leucocytes to migrate towards the area of inflammation and is associated with recurrent life-threatening bacterial and fungal infections. Pyoderma gangrenosum(PG) is an uncommon noninfectious neutrophilic dermatosis, characterized by recurrent, necrotic ulcers. It is a diagnosis of exclusion and can be challenging and its management is empirical, with local(topical tacrolimus or intralesional triamcinolone) or systemic immunosuppressive therapy (oral or intravenous glucocorticoids, sulfasalazine, especially in cases associated with crohn’s disease, cyclosporine and, recently, anti-TNF drugs such as Infliximab, Etanercept, Adalimumab). Though skin ulcerations are common, predominant clinical presentation as PG can often mimic other diseases. It is unusual in children even more in LAD-I. Here we present a Yemenian family with LAD-I from consanguineous relatives. All patients had history of chronic recurrent skin ulcerations without any bleeding tendency, associated with persistent neutrophilia and requiring steroids and antibiotics. There was no history of delayed cord separation and the condition was initially diagnosed as epidermolysis bullosa, but successively as PG. LAD-I should be kept in mind while evaluating patients with PG especially in children with persistent neutrophilia in the absence of other rheumatological disorders. Its diagnosis is extremely important from the management perspective, as treating these patients without adequate antibiotic cover may be fatal, as happened to one of our patient, and these patients often require hematopoietic stem cell transplantation for permanent cure. Therefore, genetic counseling especially in population with high consanguinity is mandatory. Journal of Cosmetology & Trichology | ISSN : 2471-9323 Cosmetology Conference 2019 Volume 5 Page 45
J Cosmo Trichol 2019, Volume 08 15th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal Combined use of topical imiquimod and 5-fluorouracil in the management of in-transit cutaneous melanoma: A Case Report and Literature Review Sheida Naderi-Azad1, Marisa Ponzo2 1 University of Toronto Medical School, Canada 2 University of British Columbia Faculty of Medicine, Canada S tatement of the Problem: While there are numerous therapeutic options available for in-transit cutaneous melanoma, the treatments are often unsuccessful due to suboptimal response rates. This motivates the use of combination therapies such as imiquimod and 5-fluorouracil to increase therapeutic efficacy. Imiquimod and 5-fluorouracil have distinct mechanisms of action, with imiquimod binding to toll-like receptor 7 and 8 on leukocytes and 5-FU inhibiting thymidylate synthase and inhibiting DNA synthesis. The purpose of this case report is to describe the course of an 87-year-old female with an 8-year history of cutaneous melanoma. Findings: The patient was initially managed with a wide local excision of the right shin lesion, as well as a split-thickness graft. She was further treated with a combination of 5% topical imiquimod cream and 5% 5-fluorouracil cream. There was complete clearance within 23 months, and the patient has been disease- free since. Conclusion & Significance: Given the patient’s complete clearance and disease-free state since treatment, we postulate that imiquimod and 5-FU’s synergistic mechanisms of action provide a valuable potential for targeting in-transit cutaneous melanoma in patients. Journal of Cosmetology & Trichology | ISSN : 2471-9323 Cosmetology Conference 2019 Volume 5 Page 46
J Cosmo Trichol 2019, Volume 08 15th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal Novel psoriasis therapeutics: examining the anti-inflammatory utility of anti-anxiolytic medications Sheida Naderi-Azad University of Toronto Medical School, Canada S tatement of the Problem: Psoriasis is a debilitating autoimmune disease defined by erythematous, pruritic, and scaly plaques. Yet, this disease also has numerous extracutaneous associations including depression, heart disease, arthritis, and inflammatory bowel disease. The combination of physical and mental manifestations of psoriasis can be explained, respectively, by inflammatory cytokines that act on skin cells to create scaly patches and brain cells to alter one’s mental state. The purpose of this study is to discuss the novel use of anti-anxiolytic medications to address psoriasis therapeutics. Methodology & Theoretical Orientation: To obtain these results, various search terms such as psoriasis and anti-anxiolytics were utilized. Furthermore, the articles were selected based on recency of publication as well as depth of detail regarding the specific immunologic mechanisms by which anti- psychotics exert their therapeutic effects. Findings: The results show that educing anxiety can reduce the release of stress compounds, thus reducing body’s inflammatory reaction. Specifically, stress signals such as CRH and substance P contribute to the release of inflammatory cytokines such as TNF-α and interleukins. Conclusion & Significance: Psoriasis provides evidence for the connection between the psychiatric symptoms caused by changes in the brain and cutaneous symptoms caused by changes in the skin. The bidirectionality of these interactions is used to create a novel use for anti-anxiolytic medications in treating psoriatic symptoms. Journal of Cosmetology & Trichology | ISSN : 2471-9323 Cosmetology Conference 2019 Volume 5 Page 47
J Cosmo Trichol 2019, Volume 08 15th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal Examining the role of inflammasomes in psoriasis, atopic dermatitis, and contact dermatitis: A Review Sheida Naderi-Azad University of Toronto Medical School, Canada S tatement of the Problem: Inflammasomes are intracellular multiprotein complexes that comprise part of the innate immune response. They are composed of three elements; the pattern recognition receptor, an adaptor protein, and a caspase-1 enzyme that results in production of pro-inflammatory cytokines (Dunn et al., 2012). Inflammasome disorders have been linked to an increasing number of diseases. Autoinflammatory diseases refer to disorders in which local factors lead to the activation of innate immune cells, causing tissue damage in the absence of autoantigens and autoantibodies. The purpose of this review is to discuss the involvement of inflammasomes in inflammatory skin conditions such as psoriasis, atopic and contact dermatitis by the production of the interleukin-1 (IL-1) family of cytokines. Findings: The results for contact dermatitis show that inflammasome-dependent secretion of IL-1B, IL-18 and IL-1R cytokines results in T-cell inflammation in sensitized individuals (Li and Zhong 2014, Watanabe et al., 2007, Coehlo de Sa and Nato 2016). Inflammasomes have also been shown to contribute to AD by upregulating the epidermal expression of IL-1B and IL-1RA (Machura et al., 2018, Hay et al., 2012, Kezic et al., 2012). IL-1β and IL-18 also play a key role in psoriasis, as indicated by the involvement of NLRP1, NLRP3 and CARD8 polymorphisms, as well as upregulation of caspase-1 and AIM-2 for cytokine production (Carlstrom et al., 2012, Ekman et al., 2014, Johansen et al., 2007, Dombrowski et al., 2011). Conclusion & Significance: The inflammasome- mediated secretion of IL-1 family cytokines in contact dermatitis, atopic dermatitis and psoriasis implicates the potential role of caspase, NLR and IL-targeted therapy for treatment of inflammatory skin conditions. Journal of Cosmetology & Trichology | ISSN : 2471-9323 Cosmetology Conference 2019 Volume 5 Page 48
J Cosmo Trichol 2019, Volume 08 15th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal What wound care specialists should know about Pyoderma Gangrenosum Sheida Naderi-Azad University of Toronto Medical School, Canada S tatement of the Problem: Pyoderma gangrenosum (PG) is a rare, destructive neutrophilic dermatosis characterized by a progressive, necrotizing process. The classic pyoderma involves a full-thickness ulcer with blue undermining borders. Patients exhibit “pathergy” with the appearance of new lesions after local trauma such as surgical procedures, debridement, and biopsy, thus suggesting altered inflammatory response (Soncini et al., 2016). The treatment of PG involves both systemic therapy such as corticosteroids and antibiotics, and topical therapy like wound dressings and compression therapy. The purpose of this review is to discuss the benefits of wound dressing and compression therapy in treating acute wounds from PG. Methodology & Theoretical Orientation: To obtain these results, search terms including “pyoderma gangrenosum”, “wound dressing” and “compression therapy” were utilized. Furthermore, the articles were selected based on recency of publication as well as depth of detail regarding the specific PG types they help target. Findings: The results show that numerous dressings are used to target each subtype including films for superficial skin disruption, hydrogels for dry eschars, absorptive alginates for exudates, hydrocolloids for granulating wounds, and silver iodide for colonized wounds. In addition, compression therapy is used for healing ulcers and preventing recurrent ulcers. Conclusion & Significance: The results of this study will be used to enhance wound care in PG by individualizing each dressing depending on the nature of the PG wound. The use of both wound dressings and compression therapy will facilitate improved healing of this debilitating dermatosis. Journal of Cosmetology & Trichology | ISSN : 2471-9323 Cosmetology Conference 2019 Volume 5 Page 49
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