Oncology International Journal of Cancer Research and Treatment - Karger Publishers
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99 | 2 | 21 Oncology International Journal of Cancer Research and Treatment
Healthcare products
and services by Karger.
For clinicians, patients,
and caregivers.
KI20248
Oncology
International Journal of Cancer Research and Treatment
Founded 1948 as “Oncologia” by H.R. Schinz
Continued by V. Richards (1967–1975), H. Wrba (1976–1992), P.P. Carbone (1993–2002),
D.L. Trump (2002–2007)
Editor-in-Chief
Maurie Markman – Cancer Treatment Centers of America, Philadelphia, PA, USA
Oncology and Informatics
Section Editor
Paul Martin Putora – Kantonsspital St. Gallen, St. Gallen, Switzerland
Associate Editors
Michael Baudis – University of Zurich, Zurich, Switzerland
Beth Beadle – Stanford University, Stanford, CA, USA
Issam El Naqa – Moffitt Cancer Center, Tampa, FL, USA
Frank A. Giordano – University of Bonn, Bonn, Germany
Nils Nicolay – University of Freiburg, Freiburg, Germany
Editorial Board
Al B. Benson – Northwestern University, Chicago, IL, USA
Alex Y.C. Chang – Johns Hopkins Singapore, Singapore, Singapore
Ann-Lii Cheng – National Taiwan University Hospital, Taipei, Taiwan
James F. Cleary – University of Wisconsin Medical School, Madison, WI, USA
Manfred Dietel – Universitätsklinikum Charité, Berlin, Germany
Giuseppe Di Lorenzo – Dea Nocera-Pagani-Scafati, ASL Salerno, Salerno, Italy
Patrick Dufour – Centre Paul Strauss, Strasbourg, France
Marc S. Ernstoff – Roswell Park Cancer Institute, Buffalo, NY, USA
Marwan G. Fakih – City of Hope Comprehensive Cancer Center, Duarte, CA, USA
Juan-José Grau – University of Barcelona, Barcelona, Spain
Hinrich Gronemeyer – Institut de Génétique et de Biologie Moléculaire et Cellulaire,
Illkirch, France
Daniel F. Hayes – University of Michigan, Ann Arbor, MI, USA
Candace S. Johnson – Roswell Park Cancer Institute, Buffalo, NY, USA
Michael Kelley – Duke University / VA Hospital, Durham, NC, USA
Vessela N. Kristensen – Oslo University Hospital, Oslo, Norway
Lalit Kumar – Dr. Brambedkar Institute, New Delhi, India
Patrick J. Loehrer – Indiana University Medical Center, Indianapolis, IN, USA
(Continued on next page)
Printed in Germany on acid-free and non-aging paper
(ISO 9706) by Stückle Druck, Ettenheim(Continued)
James R. Marshall – Roswell Park Cancer Institute, Buffalo, NY, USA
Silvio Monfardini – Istituto Palazzolo, Fondazione Don Gnocchi, Milan, Italy
Rafael M. Nagler – Rambam Medical Center, Haifa, Israel
Ryuzo Ohno – Aichi Cancer Center Hospital, Nagoya, Japan
Bernhard Pestalozzi – Universitätsspital Zurich, Zurich, Switzerland
Herbert M. Pinedo – VUMC - Cancer Center Amsterdam, Amsterdam, The Netherlands
Elizabeth A. Repasky – Roswell Park Cancer Institute, Buffalo, NY, USA
Daniele Santini – Università Campus Bio-Medico, Rome, Italy
Andrzej Semczuk – Lublin University, Lublin, Poland
Egbert F. Smit – VU University Medical Centre, Amsterdam, The Netherlands
Cora N. Sternberg – San Camillo Forlanini Hospital, Rome, Italy
Roger Stupp – Northwestern University, Chicago, IL, USA
Martin S. Tallman – Memorial Sloan Kettering Cancer Center, New York, NY, USA
Shinji Tanaka – Hiroshima University Hospital, Hiroshima, Japan
Mei Tian – The University of Texas, Houston, TX, USA
Donald L. Trump – Roswell Park Cancer Institute, Buffalo, NY, USA
Thomas Wiegel – Universitätsklinikum Ulm, Ulm, Germany
Hong Zhang – University Medical PET Center, Hangzhou City, China
© 2021 S. Karger AG, Basel
www.karger.com
karger@karger.comJournal Information
Aims and Scope
Although laboratory and clinical cancer research need to be closely linked, observations at
the basic level often remain removed from medical applications. This journal works to ac-
celerate the translation of experimental results into the clinic, and back again into the labo-
ratory for further investigation. The fundamental purpose of this effort is to advance clinical-
ly-relevant knowledge of cancer, and improve the outcome of prevention, diagnosis and
Guidelines for Authors treatment of malignant disease. The journal publishes significant clinical studies from cancer
We strongly encourage authors to read
the Guidelines for Authors at
programs around the world, along with important translational laboratory findings, mini-
www.karger.com/ocl_guidelines prior to reviews (invited and submitted) and in-depth discussions of evolving and controversial top-
submitting an article. ics in the oncology arena. A unique feature of the journal is a section which focuses on
rapid peer-review and subsequent publication of short reports of phase 1 and phase 2 clin-
ical cancer trials, with a goal of insuring that high-quality clinical cancer research quickly
enters the public domain, regardless of the trial’s ultimate conclusions regarding efficacy or
toxicity.
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www.karger.com
karger@karger.comVol. 99, No. 2, 2021
Contents
Review
65 Endometrial Cancer: When Upfront Surgery Is Not an Option
Barcellini, A.; Roccio, M. (Pavia); Laliscia, C. (Pisa); Zanellini, F.; Pettinato, D.; Valvo, F.; Mirandola, A.;
Orlandi, E. (Pavia); Gadducci, A. (Pisa)
Oncology and Informatics – Review
72 Cholangiocarcinoma Evaluation via Imaging and Artificial Intelligence
Yang, C.M.; Shu, J. (Luzhou)
Clinical Studies
84 Aromatase Inhibitors in Postmenopausal Women with Hormone Receptor-Positive
Breast Cancer: Profiles of Psychological Symptoms and Quality of Life in Different
Patient Clusters
Borreani, C.; Alfieri, S.; Infante, G.; Miceli, R.; Mariani, P.; Bosisio, M.; Vernieri, C.; Bianchi, G.V.;
Capri, G. (Milan)
96 Predictive Value of 18F-Fluorodeoxyglucose Positron Emission Tomography or
Positron Emission Tomography/Computed Tomography for Assessment of Occult
Lymph Node Metastasis in Non-Small Cell Lung Cancer
Seol, H.Y.; Kim, Y.S.; Kim, S.-J. (Yangsan)
105 Risk Factors for Cisplatin-Induced Nephrotoxicity: A Multicenter Retrospective Study
Miyoshi, T. (Beppu); Uoi, M.; Omura, F. (Fukuoka); Tsumagari, K. (Miyakonojo); Maesaki, S. (Koushi);
Yokota, C. (Kumamoto)
Clinical Translational Research
114 TERT Promoter Mutation in Serum Cell-Free DNA Is a Diagnostic Marker of Primary
Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease
Akuta, N.; Kawamura, Y.; Kobayashi, M.; Arase, Y.; Saitoh, S.; Fujiyama, S.; Sezaki, H.; Hosaka, T.;
Kobayashi, M.; Suzuki, Y.; Suzuki, F.; Ikeda, K.; Kumada, H. (Tokyo)
Reducing the Worldwide Burden of Cancer
124 The Emergence of Artificial Intelligence within Radiation Oncology Treatment
Planning
Netherton, T.J.; Cardenas, C.E.; Rhee, D.J.; Court, L.E. (Houston, TX); Beadle, B.M. (Stanford, CA)
Cover illustration
© S. Karger AG, Basel
© 2021 S. Karger AG, Basel
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