Nutrition & Immunity In the 'New Normal' - APAC Webinar, June 23rd, 2020 - BASF Nutrition
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Nutrition & Immunity
In the ‘New Normal’
APAC Webinar, June 23rd, 2020
What we will speak to you about today
What is the state of How is the market How can we approach What product solutions
consumer behavior? developing? the immune health space to meet the specific needs
in the ‘new normal’ ? of target consumers?
Insights into consumer What trends are going Formulating with ingredients Some concepts to help inspire
needs, priorities, to pave the way for founded in science to meet product innovation with the
purchasing behavior new opportunities, consumer needs consumer in mind
to differentiate in an Trusted micronutrients and
already crowded space emerging ingredients
2 24.06.2020 | BASF Nutrition & Immunity Webinar APAC
Allergens are a major
seasonal challenge for our
immune system with an
impact on the quality of life
3 24.06.2020 | BASF Nutrition & Immunity Webinar APAC
Living in dense
populations exposes
us to pathogens &
makes it difficult
to stay healthy
4 24.06.2020 | BASF Nutrition & Immunity Webinar APAC
Building a strong immune system should start early in life 5 24.06.2020 | BASF Nutrition & Immunity Webinar APAC
Elderly people have a
natural decline in immune
defense & requires
additional support
6 24.06.2020 | BASF Nutrition & Immunity Webinar APAC
2020 has been an extraordinary year Bringing lasting changes to our lives 7 24.06.2020 | BASF Nutrition & Immunity Webinar APAC
Consumer behavior changes drastically with the pandemic…
1 Eating healthy, doing exercise & the environment are of higher
priority for consumers, in APAC especially
2 Consumers in most countries expect to spend more on
healthcare products & in-home food items
3 Immunity is a key health concern & sales of dietary supplements surges
as consumers seek to proactively care for their immune health
8 24.06.2020 | BASF Nutrition & Immunity Webinar APACOpportunity 1:
Science-backed immunity solutions to meet specific consumer needs
▪ Micronutrients form base of science-backed immune health solutions
▪ Beyond Vitamin C, consider other ingredients which have authorized immunity claims
globally, for example: Vitamins A, B12, B6, C, D, Zinc, Folate, Copper, Iron, Carotenoids
▪ Quality ingredients, clear consumer communications, align with reputable health bodies
9 24.06.2020 | BASF Nutrition & Immunity Webinar APACOpportunity 2:
Functional foods & beverages plays a key role, on top of dietary supplements
▪ Dramatic increase in global searches for the word ‘food’ and ‘immune system’
in between Feb & March 2020
▪ Consumers are looking more to ‘real food’ to get their nutrients daily
▪ An opportunity pocket exists for immune health in functional nutrition
10 24.06.2020 | BASF Nutrition & Immunity Webinar APACEven as some countries start opening up, we move not
‘back-to-normal’ but into a ‘New Normal’
Increased instances of working and
studying from home arrangements 1 New ways of staying fit
Even as gyms and fitness centres re-open, the need
for safe-distancing and new virtual fitness & exercise
solutions could change how we exercise
2 Increased screen time
This will be hard to avoid with more virtual meetings,
home-based learning & more streaming & web-based
entertainment consumption (movies & TV series)
3 Healthier snacking for the family
The importance of choosing healthier snacks takes on
more importance for consumers, especially gate-keepers
who opt for snacks with added benefits for their families
11 24.06.2020 | BASF Nutrition & Immunity Webinar APACThe immune system:
What is immunocompetence
The role of nutrition
12 24.06.2020 | BASF Nutrition & Immunity Webinar APACThe immune system functions along three main lines of defense
3
2
2 Innate immunity: 1 3 Adaptive immunity:
▪ Builds up during lifetime
▪ Available at birth
▪ Reacts quickly with
▪ Reacts quickly in an
pathogen-specific antibodies
unspecific manner
▪ Antibodies produced after
▪ Key defense during
vaccination or first exposure
first-time exposure to
to pathogens; available for
pathogens
lifetime or certain period
▪ Often not fast enough
▪ Pathogens are bound by
to prevent symptoms
antibodies and destroyed by
of disease
immune cells before
symptoms of disease occur
Source: Muller L et al, The Immune System and Its
13 24.06.2020 | BASF Nutrition & Immunity Webinar APAC
Dysregulation with Aging, Sprinter Link, 2019What is immunocompetence?
▪ To be immunocompetent simply means that the immune system is working properly and that the
body is capable of mounting an appropriate immune response, when necessary.
Role NORMAL RESPONSE ABNORMAL RESPONSE
▪ Identification and protection against Overactive e.g. allergy, asthma, eczema etc.
Defense
pathogenic microorganisms and toxins Deficient: immuno-deficiency
▪ Autoimmune diseases: a case of mistaken
Auto- ▪ Recognition of own tissues and identity in which the body's immune
tolerance maintaining tolerance system, which ordinarily attacks intruders
like viruses and bacteria, attacks itself.
Immune ▪ Identifying and removing the damaged,
▪ Tumor generation or frequent infection etc
Surveillance old or otherwise changed cells
14 24.06.2020 | BASF Nutrition & Immunity Webinar APACLifestyle factors leading to immuno-compromise during adulthood
▪ The risk of infection is also influenced by gender, early programming, vaccination history,
pathogen exposure, specific health conditions, and diseases.
15 24.06.2020 | BASF Nutrition & Immunity Webinar APAC Source: Maggini et al., 2018Health ingredients have specific functions & strengthen the
immune system
▪ Specific micronutrients work together to reduce the risk, duration and severity of infections. These include
vitamin A, B6, folate, B12, C, D, E, as well as minerals like zinc, copper, iron, magnesium and selenium.
Vitamin A Vitamin D Carotenoids 2‘-Fucosyllactose
• Skin, eye, lung, and gut barriers • Promotes growth of healthy
inhibiting pathogen intrusion • Skin, eye, lung, and gut barriers • Beta-carotene: same effects as bacteria in the gut
inhibiting pathogen intrusion vitamin A
• Effectiveness of vaccinations • Inhibits pathogens in the gut Lower risk of allergies,
• Regulation of anti-microbial • All carotenoids: antioxidant
• Precursor of retinoic acid, key defense proteins function, tissue protection • Modulates immune system in respiratory infections,
regulator in the immune system; the gut & systemically
autoimmune diseases,
chronic inflammation
Vitamin E Vitamin B12 DHA/EPA and an overall
strengthened
immune system
• Skin, eye, lung, and gut barriers
inhibiting pathogen intrusion • Modulation of immune cells
• Anti-inflammatory function • Steering lymphocytes to • Anti-inflammatory function
infected tissues
• Stimulation of immune cells, • Stimulation of immune cells
particularly in elderly people • Skin, eye, lung, and gut barriers
inhibiting pathogen intrusion
16 24.06.2020 | BASF Nutrition & Immunity Webinar APACSummary of selected systematic review and meta-analysis
reporting on Vitamin D and respiratory infections
17 24.06.2020 | BASF Nutrition & Immunity Webinar APAC Calder et al 2020Vitamin D intake recommendations by scientists
◼ For preventing VD deficiency during lockdown:
“400 – 2000 IU of vitamin D3 supplementation could assist in
preventing vitamin D deficiency during lockdown, without significant
risk for harms” (Alpalhao M et al, 2020)
„Vitamin D3 supplementation, daily or weekly, at daily equivalent doses
of 1000–4000 IU, is advisable. (…) Both accommodate the anticipated
higher needs across the lifespan incurred by lockdown measures,
immobilization, and hospitalization.“ (Chakhtoura M et al, 2020)
◼ For increasing VD levels to recommended optimum:
“To reduce the risk of infection, it is recommended that people at risk of
influenza and/or COVID-19 consider taking 10,000 IU/d of vitamin D3
for a few weeks to rapidly raise 25(OH)D concentrations, followed
by 5000 IU/d. The goal should be to raise 25(OH)D concentrations
above 40–60 ng/mL (100–150* nmol/L).“(Grant WB et al, 2020; Grant
WB et al, 2020).
18 24.06.2020 | BASF Nutrition & Immunity Webinar APAC For comparison: 75 nmol/L are considered optimum for bone health (Int. Osteoporosis Foundation)HMO: Prebiotic 2’-FL benefits immune system in the gut & beyond
Source: Orczyk-Pawilowicz M & Lis-Kuberka J, 2020
19 24.06.2020 | BASF Nutrition & Immunity Webinar APACThe ‘New Normal’
Ideas for addressing
other consumer
health needs
20 24.06.2020 | BASF Nutrition & Immunity Webinar APACThe ‘New Normal’ for working adults:
Work-from-home, less time exercising outdoors
21Concept
(ADULTS) Booster Cold Brew with Tonalin® CLA
The perfect boost to kickstart your day with the benefits of Tonalin® CLA, Vitamins A, B & D
What is the market need for this meal
replacement beverage?
▪ More than being just a meal replacement, this beverage provides the proven
benefits of vitamins A, B, D for immunity as well as an energy boost!
▪ Fortified with Tonalin® CLA and protein to help consumers reduce body fat &
achieve fitness goals
▪ This meal replacement beverage with Tonalin® CLA and caffeine is perfectly
suited to start the day or for pre or post-workout consumption, all under
180 calories. *Please contact us
for details on this
Why Tonalin® & what are the unique benefits? concept formulation
▪ Each serving contains 1.5g of Tonalin® CLA, half the daily efficacious dose
▪ Sourced from natural safflower oil, Tonalin® CLA is the most clinically
researched CLA ingredient in the market
▪ Tonalin® CLA: helps to reduce body fat, and helps to build and maintain INGREDIENTS: LOWFAT MILK, WATER, WHEY PROTEIN, CONTAINS 2% OR
lean muscle mass LESS OF THE FOLLOWING: COFFEE EXTRACT, SUGAR, CLA (TONALIN® TG
80), CANOLA OIL, PECTIN, NATURAL FLAVOR, POTASSIUM PHOSPHATE,
SUCRALOSE, ACE K, BETA CAROTENE, SODIUM ASCORBATE.
BASF INGREDIENTS IN BOLD
A market launch is subject to local regulatory requirements.
®
22 24.06.2020 | BASF Nutrition & Immunity Webinar APAC Registered trademark of BASF in several countries.
Published by BASF Human NutritionWhat is CLA and where can it be found?
▪ Conjugated Linoleic Acid (CLA) is blend of Omega-6 and Omega-7 polyunsaturated fatty acid isomers.
▪ CLA was discovered in 1979 and identified in 1987.
Where is it found? What are the key isomers?
▪ CLA naturally exists in ruminant t10c12 CLA
meat products (beef) and dairy
Product of animals
(especially grass-fed) Tonalin®Body composition effect
▪ CLA consumption has declined key
with societal shifts away from beef
isomers c9t11 CLA
and high-fat dairy consumption Product of animals
▪ Industrially produced CLA is Anti-inflammatory effect
naturally-sourced from
safflower oil
c9c12 linoleic acid
(non-conjugated)
Eg. corn oil, soybean oil
Product of plants and animals
23 24.06.2020 | BASF Nutrition & Immunity Webinar APACTonalin® CLA provides sustainable benefits
Quick weight loss Yo-Yo Effect
ingredients
Long-term
fat loss
Phase I: < 12 weeks Phase II: Long-term
▪ Quick measurable weight loss, ▪ Keeps body fat & weight constant by
not always fat loss managing body fat vs. lean body mass
▪ May be only water loss ▪ Prevents yo-yo effect
24 24.06.2020 | BASF Nutrition & Immunity Webinar APACMeta-analysis demonstrates fat loss benefits of Tonalin®
What was done? Meta-analysis of RCT‘s: Fat loss vs. time
A meta-analysis compiled all double-blind, randomized,
placebo controlled clinical trials on CLA featuring a validated 1.0
Each dot is a treatment group from a
relative to placebo (kg)
body-composition method (eg. DEXA scan) 0.5
Change in fat mass
randomized, controlled clinical trial
0.0
▪ Of 20 trials selected, 15 featured Tonalin® CLA 0 20 40 60 80 100 120
-0.5
▪ Trials on normal, overweight, and obese populations
▪ n=1191 total clinical trial subjects -1.0
▪ Duration 3 – 24 weeks -1.5
-2.0
-2.5
What was found? -3.0
Overall conclusion: supplementation with CLA is effective Length of treatment (weeks)
in reducing body fat and maintaining reductions long-term
▪ CLA causes a modest reduction in fat (~90g lost per week or
~1kg lost in 3 months) relative to placebo at a dose of 3.0g CLA/d
Doses tested:
▪ Fat loss is linear for 6 months then losses are maintained up to Range from 1.0-6.8g/d active CLA isomers
2 years. This is especially remarkable given the average person ▪ Suggested effective dose 3.0g/d
gains about a pound of fat per year. ▪ Minimum effective dose 1.7g/d
24.06.2020 | BASF Nutrition & Immunity Webinar APAC Whigham, et al. Am J Clin Nutr 2007; 85:1203
25The ‘New Normal’ for kids:
Home-based learning & more screen time
26Concept
(KIDS & YOUTH) Eye-Shield Chewable Tabs
An appealing format for children & youths increasingly exposed to the harmful effects of blue light
What is the market need for this supplement?
▪ More than 1/3 of consumers in APAC are concerned about eye health. Supplement Facts
▪ Affinity of electronic devices are very high amongst Asian populations, and Lutein (Xangold®
young children are being exposed to electronic earlier, with longer 10% CWD)
exposure time per day. (= as free lutein)
▪ Gate-keepers (mothers) want to protect their children’s eyes but needs an
appealing format to ensure compliance. Vitamin E
Vitamin B1
*Please
Vitamin B2 contact us
Vitamin B6
for details on this
Why Xangold® & what are the unique benefits? Pantothenic acid
▪ Each serving of 4 tabs provides 2.5mg of Xangold® Lutein per day.
concept
Vitamin B12 formulation
Blue Light
▪ Sourced from natural marigold flowers from South America, Xangold® protection formula
Dosage 4
Lutein esters reduces the damaging effects of blue light to the retina and
chewables per day
improve visual performance
▪ Vitamin E helps to reduce oxidative damage in the eye
▪ B Vitamins may help maintain normal optic nerve function and may support
the treatment of eyestrain
A market launch is subject to local regulatory requirements.
®
27 24.06.2020 | BASF Nutrition & Immunity Webinar APAC Registered trademark of BASF in several countries.
Published by BASF Human NutritionWhat is lutein and where can it be found?
▪ It is a plant pigment that plays an important role in photosynthesis
and in the plant’s protection against UV light damage
Where is it found?
▪ Lutein is mainly found in kale, spinach and other green leafy vegetables,
as well as in some yellow / orange fruits. For dietary supplements, lutein
is sourced from the yellow petals of Marigold flowers.
▪ Lutein occurs naturally in 2 different chemical forms:
In the ESTERIFIED form in In the non-esterified or FREE
yellow / orange fruits as form in dark leafy vegetables as
Lutein Esters “Free” Lutein
28 24.06.2020 | BASF Nutrition & Immunity Webinar APACClose up on lutein and blue light
▪ The macula is responsible for central vision.
▪ Dietary Lutein and Zeaxanthin are
Blue light reaches human macula and deposited in the macula.
causes oxidative stress and inflammation.
Blue Light
UV
▪ Lutein is highly concentrated in the back of the eye (macula) where it is highly vulnerable to damaging light
▪ Lutein filters blue light and has antioxidative effects protecting the sensitive cells required for vision
29 24.06.2020 | BASF Nutrition & Immunity Webinar APACProviding the right nutrients
to the right people
at the right time
30 24.06.2020 | BASF Nutrition & Immunity Webinar APACWe are among the largest players in the health field,
offering a wide portfolio
Vitamin A, Bs, CLA Natural Vitamin E HMOs
D, E, K & Antioxidants
Omega-3 Plant Sterols Carotenoids Bioactive Peptides
31 24.06.2020 | BASF Nutrition & Immunity Webinar APACWe are close to our customers & close to their markets
Ballerup
Ludwigshafen ▪ Combining expert know-how of
Illertissen
health and performance ingredients
Tarrytown Istanbul with state of the art equipment
Shanghai
▪ Deep understanding of local needs,
preferences and habits
Singapore
▪ Access to local ingredients from
Jacarei diverse cultures and tastes
Solid applications Liquid applications Food
32 24.06.2020 | BASF Nutrition & Immunity Webinar APACConcept
Seniors: Immunity Booster Effervescent Tablets
“I want to be as healthy as I was when I was younger.
My immune system needs an extra boost.”
What is the market need?
▪ Easy to consume supplements for elderly people, no big capsules
▪ Support of immune system as it naturally declines during aging
What is the consumer benefit?
▪ Provides high-dose beta-carotene, vitamin E and vitamin D3
▪ Beta-carotene is a precursor of retinoic acid, a key regulator in the
immune system; important for barrier functions as first line of Health ingredients
defense against pathogens, and for effectiveness of vaccinations
▪ Vitamin E and vitamin D3 have anti-inflammatory properties and
stimulate immune cells. *Please contact us for details
on this concept formulation
… Better immune function while aging
A market launch is subject to local regulatory requirements.
33 24.06.2020 | BASF Nutrition & Immunity Webinar APAC ®
Registered trademark of BASF in several countries.
Published by BASF Human NutritionConcept
Adults: Immunity Power Juice
“I life in a big city and my life is rather stressful.
I want to have a strong immune system”
What is the market need?
▪ Beverages for immune support
▪ Good taste, with herbals, fruits & vegetables (“superfoods”)
What is the consumer benefit? Red berries Kiwi & Spinach
Orange & Carrot
▪ Provides (pro)vitamin A, E & C in a modern type of “ACE” beverage Curcuma Cinnamon Ginger
▪ Beta-carotene is a precursor of retinoic acid, a key regulator in the
immune system. Vitamin E and Vitamin C have antioxidant, tissue Health ingredients
protective function and stimulate immune cells
▪ Fruits & vegetables are popular “superfoods”
▪ Herbals are traditionally used for immune support *Please contact us for details
on this concept formulation
… Better immune function when life is busy
A market launch is subject to local regulatory requirements.
34 24.06.2020 | BASF Nutrition & Immunity Webinar APAC ®
Registered trademark of BASF in several countries.
Published by BASF Human NutritionConcept
Adults: Daily Defense Antioxidant Capsules
“I live in a crowded, polluted city and wonder
how I can protect myself better.”
What is the market need?
▪ Easy to swallow capsules for daily immune support
What is the consumer benefit?
▪ Provides 24 mg of antioxidants per capsule including
beta-carotene, lutein, lycopene and vitamin E
▪ Helps to evenly distribute fat-soluble antioxidants in body tissues Health ingredients
▪ Antioxidant combination helps replenish the body’s antioxidant
defence network and supports barrier immune function
▪ In addition, beta-carotene is a precursor of retinoids, which are
key regulators in the immune system. *Please contact us for details
on this concept formulation
… Better protection against environmental stressors
A market launch is subject to local regulatory requirements.
35 24.06.2020 | BASF Nutrition & Immunity Webinar APAC ®
Registered trademark of BASF in several countries.
Published by BASF Human NutritionLab-tested Concept
Adults: Prebilac® plus Vitamin Immune Sachet
“I want to take a supplement that helps
boost my gut immune system.”
What is the market need?
▪ Supplements that can be mixed easily into beverages & foods
▪ Neutral taste or, alternatively, fruity taste (lemon, orange)
What is the consumer benefit?
▪ 2’-FL fosters a healthy gut by facilitating the growth of
beneficial bacteria and supporting intestinal immune functions Health ingredients
▪ Vitamin D3 and vitamin B12 contribute to the normal function
of the immune system
▪ Vitamin B2 contributes to the protection of cells from oxidative
stress *Please contact us for details
on this concept formulation
… Better immune function in the gut
A market launch is subject to local regulatory requirements.
36 24.06.2020 | BASF Nutrition & Immunity Webinar APAC ®
Registered trademark of BASF in several countries.
Published by BASF Human NutritionThis document, or any answers or information provided herein by BASF, does not constitute a legally binding obligation of BASF. While the descriptions, designs, data and information contained herein are presented in good faith and believed to be accurate, they are provided for your guidance only. Because many factors may affect processing or application/use, we recommend that you make tests to determine the suitability of a product for your particular purpose prior to use. It does not relieve our customers of the obligation to perform a full inspection of the products upon delivery or any other obligation. The claims and supporting data provided in this publication have not been evaluated for compliance with any jurisdiction’s regulatory requirements and the results reported may not be generally true under other conditions or in other matrices. Users must evaluate what claims and information are appropriate and comply with a jurisdiction’s regulatory requirements. NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, ARE MADE REGARDING PRODUCTS DESCRIBED OR DESIGNS, DATA OR INFORMATION SET FORTH, OR THAT THE PRODUCTS, DESIGNS, DATA, OR INFORMATION MAY BE USED WITHOUT INFRINGING THE INTELLECTUAL PROPERTY RIGHTS OF OTHERS. IN NO CASE SHALL THE DESCRIPTIONS, INFORMATION, DATA, OR DESIGNS PROVIDED BE CONSIDERED A PART OF OUR TERMS AND CONDITIONS OF SALE.
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