21 Australasian Society for ...
←
→
Page content transcription
If your browser does not render page correctly, please read the page content below
ASI NEWS SEPTEMBER 2019
NEWER AND BETTER
ASI WEBSITE P4
6
CLINICAL &
21
ASI-ADVANCED
CONTACT US
AUSTRALIAN AND NEW
ZEALAND SOCIETY FOR
IMMUNOLOGY INC.
TRANSLATIONAL IMMUNOLOGY SCHOOL ASI INC. SERETARIAT
IMMUNOLOGY 22-25th July, 2019, Iluka PO BOX 1371,
RECEIVES ITS FIRST Retreat, Rawson, Victoria MITCHAM NORTH 3132
EVER IMPACT FACTOR PH: 03 8393 9388
immunology.org.au/contact-us
CONTENTS ASI NEWSLETTER SEPTEMBER 2019
CONTENTS
SETTING THE BAR & MOVING ON FAST............. 3 2019 DOI POSTER CORNER............................... 23
Angelica Lau Gabriela Khoury & Angelica Lau
NEWER AND BETTER: ASI WEBSITE LAUNCH... 4 BD SCIENCE COMMUNICATION
Tyani Chan AWARD RECIPIENT 2018.................................... 30
Amy Prosser
CLINICAL & TRANSLATIONAL IMMUNOLOGY
RECEIVES ITS FIRST EVER IMPACT FACTOR..... 6
THE IUIS CORNER............................................... 33
Tyani Chan & Rajiv Khanna
J. Alejandro Lopez, IUIS Representative
CTI: SPECIAL FEATURE ON CELL AND
VISITING SPEAKERS: MORE TO COME............ 35
GENE THERAPY..................................................... 9
Stuart Mannering
Paul Beavis and Phillip Darcy
BRANCH REPORTS............................................. 37
48TH ANNUAL ASI MEETING & SIG
NZ Branch Report................................................37
WORKSHOPS........................................................10 Ries Langley, NZ Councillor
QLD Branch Report...............................................39
WOMEN’S INITIATIVE NEWS.............................. 12 Sumaira Hasnain, QLD Councillor
Kylie Quinn
NSW Branch Report............................................. 41
GORDON ADA SENIOR AWARD 2019 Helen McGuire, NSW branch Councillor
RECIPIENT............................................................ 14 PUBLICATIONS OF INTEREST............................ 42
Dr Natalie Borg Our Sustaining Members
JARED PURTON AWARD RECIPIENT 2019........ 16 AUSTRALIAN AND NEW ZEALAND
Dr Lucy Sullivan SOCIETY FOR IMMUNOLOGY INC..................... 44
ASI-ADVANCED IMMUNOLOGY SCHOOL......... 21
Sarah Dart & Steven Heaton
14 16 33
GORDON ADA SENIOR JARED PURTON AWARD THE IUIS CORNER
AWARD RECIPIENT 2019 RECIPIENT Immunologist Faith Osier
Dr Natalie Borg, Immunity Dr Lucy Sullivan, The of Kenya plans to train
and Immune Evasion Lab, Peter Doherty Institute for over 1,000 African
Monash University Infection and Immunity, scientists in the discipline
University of Melbourne during the next decade.
2
EDITORIAL ASI NEWSLETTER SEPTEMBER 2019
SETTING THE BAR &
MOVING ON FAST
Angelica Lau, Newsletter Editor
newsletter@immunology.org.au
It has been roughly 2 months initiatives and changes led by
ASI’s flagship journal Clinical &
since the celebrations of Day of our current council – officially
Immunology across Australia. We renaming as the Australian
Translational Immunology has
are now well and truly into the and New Zealand Society for also achieved a ground-breaking
second half of 2019 - all those Immunology, reinvigorating the new impact factor!
grant deadlines, review due Women’s Initiative, refining the
dates, abstract submissions… Gender Equity policies... It has Gordon Ada Senior Award and
they’re all happening! Speaking been an absolute pleasure to be the Jared Purton Award. These
of deadlines, have you registered on the receiving end of these rising stars have shared with
for the ASI Perth Annual Meeting great changes and to relay these us some of their exciting new
to be held on 8th-12th December exciting changes to you as editor. research. I hope their stories
this year? It is not too late! But But fear not, there are still more will be a real inspiration to all
before you all get carried away exciting news in this issue! you early career researchers out
with pending stress – make there!
We have now launched a brand
sure to check out some of the If you think there are certain
new ASI website with a sleek and
winning science communication news, editorials, featured articles
modern touch. The new website is
posters designed by our creative that you think would benefit
designed to be more streamlined
ASI students at the recent DOI the ASI community, I am always
and user-friendly for ASI members
outreach events! open to receive suggestions and
to apply for awards and stay up to
2019 has been without question date with society news. interesting leads! Send me an
a fast paced and an exciting email (newsletter@immunology.
ASI’s flagship journal Clinical &
year for ASI. We saw many new org.au) and let’s have a chat!
Translational Immunology has
ASI has officially launched of a
also achieved a ground-breaking
new impact factor! Make sure you
brand new ASI website – with a check out the CTI special column
modern touch, more streamlined in this issue!
and user-friendly portal for ASI We also get to hear from the
members well-deserved recipients of the
3
NEWER AND BETTER ASI NEWSLETTER SEPTEMBER 2019
NEWER AND BETTER
OUR NEW ASI WEBSITE AND SOME GREAT CHANGES
TYANI CHAN, ASI General Manager
generalmanager@immunology.org.au
It is with much excitement that
I inform you of some major
changes here at ASI. To name
a few, in the past 18 months
we have established our ASI
Strategic Goals, changed our
name, engaged AES as our
administrative support company,
and launched our brand new
website on the 28th June 2019.
The move to a new website
platform will undoubtedly
improve the efficiency of how
we operate on a daily basis and
also set us up for longer-term
sustainability on several levels.
A project spanning 18 months,
the new website was not
implemented purely for aesthetic
reasons but rather to address
some major ongoing issues
surrounding efficiency, security We hope that you take a minute Women Speakers Database.
and accuracy of our membership to explore the new website
In case you missed the emails,
management processes. (https://www.immunology.org.
here they are again:
au).
A project spanning 18 months, Click here log in to your
• First-timers: Click here for
the new website was not member profile by resetting
instructions on how to log in for
implemented purely for aesthetic
the first time
your password if this is your first
reasons but rather to address visit. All members will have an • Women Speakers: Click here
some major ongoing issues account already, so please log for how to join the Women
Speakers Database
surrounding efficiency, security
in and check that your member
details are current. You’ll
and accuracy of our membership notice you can indicate your
• Members on auto-renew:
management processes.
Click here for some important
interest in contributing to ASI, instructions about our change in
being included on the member payment processor
directory, or being listed on the
4
NEWER AND BETTER ASI NEWSLETTER SEPTEMBER 2019
Click here to log in to your member Your comments and feedback
profile by resetting your password are always welcome — just drop
if this is your first visit. me a line on generalmanager@
immunology.org.au
SO WHAT ARE THE KEY FEATURES OF OUR NEW WEBSITE?
1. The FAQs
Useful information is now contained within your member profile! You’ll be able to look this up in a
matter of seconds.
We are frequently asked:
• “What is my ASI member number?”
• “Am I a financial member?”
• “Am I eligible to apply for this ASI award?”
2. Where did the payment go?
Payments received from now on will generate tax invoices that can be downloaded later.
3. Award Status Tracking
We’ve now included a award status tracking in your profile, giving you greater confidence that we have
received your award application, plus the ability to track the progress of your application.
4. Reimbursement Status Tracking
If your award application was successful, you are now able to see that your reimbursements are being
processed.
5. Better user experience as you navigate through our website.
6.Significantly improved website security.
7. Automated registrations for new members
Quicker turnaround time for new members to join and start receiving member communications.
8.Mobile-friendliness for the 30% of you that enjoy viewing our website on
your phones.
9.So much more that won’t fit here!
5
ASI NEWSLETTER SEPTEMBER 2019
CTI RECEIVES ITS
FIRST EVER IMPACT FACTOR
TYANI CHAN, ASI General Manager,
generalmanager@immunology.org.au
RAJIV KHANNA, CTI Editor-in-Chief,
Rajiv.Khanna@qimrberghofer.edu.au
v
It’s a momentous time in history
Clinical &
when your society’s journal
receives its first ever Impact
Factor.
Clinical & Translational
Immunology (CTI) was founded
Translational
in 2012 in response to a growing
need for publishing clinically-
orientated research papers in the
Immunology
field of immunology.
CTI is an open-access, fully Impact Factor 7.271
peer-reviewed ASI journal, Clinical & Translational
covering clinical investigations Immunology
Cutting-edge advances
and trials of novel immune-based www.wileyonlinelibrary.com/journal/cti Volume 8‚ 2019
therapy, cancer immunotherapy,
in biomedical research
Editor-in-Chief: Rajiv Khanna
autoimmune disorders,
Clinical & Translational Immunology is an open
immunodeficiency, transplant access, online-only journal, seeking to cover basic,
immunology, gene therapy, translational and clinical studies in all aspects of
human immunology, including experimental
vaccine development and disease models specific to human diseases.
pathogenesis and therapy.
ASI members enjoy a discount for
Over the past year we had been publishing in Clinical & Translational
anxiously awaiting the release Immunology
of the 2018 Journal Citation cti2_v_i_ofc.indd 1 4/4/2019 2:35:59 PM
Reports, the annual publication Submit your next manuscript to Clinical & Translational Immunology
and enjoy these benefits of publishing with Wiley
by Clarivate Analytics that
It’s a momentous time in history
when your society’s journal
receives it’s first ever Impact Find out more at
www.wileyonlinelibrary.com/journal/cti
Factor.
6
CTI RECEIVES ITS FIRST EVER IMPACT FACTOR ASI NEWSLETTER SEPTEMBER 2019
ASI Members – don’t forget
provides the latest impact factors We will continue to raise the
and other information about profile and awareness of both
academic journals.
about the fantastic benefits our ASI Journals, to further
of submitting your work to increase readership, citations and
CTI, including member-only
There were certainly some key
submissions, both nationally and
indicators that we’d receive
some fantastic news. For 2017, opportunities such as the internationally.
CTI received a Scopus CiteScore 20% discount off the cost of As CTI continues to grow, we
of 3.55; a new metric that publishing, and the automatic can’t wait to bring you further
evaluates serial citation impact entry into the ‘CTI Publication exciting updates in the near
over a three-year period. When
of the Year Award’, which also future.
includes a speakers slot at the
this figure doubled in a year to
become 7.27 in 2018, CTI was
ranked as number 13 of 198 ASI Annual Scientific Meeting.
Immunology journals, placing
CTI in the 93rd percentile within 20% discount off the cost of
the Immunology category. It was publishing, and the automatic
clear that CTI was increasing in entry into the ‘CTI Publication
citation impact. of the Year Award’, which also
Needless to say, we were ecstatic includes a speakers slot at the
to hear the Impact Factor result ASI Annual Scientific Meeting.
when it was recently released Please don’t hesitate to contact
on the 21st June 2019. The 2018 CTI Editorial Office to seek
Journal Citation Reports showed presubmission enquiries. We
an incredible first Impact Factor are looking forward for younger
for CTI of 7.271! leading members of ASI to play
an important role in contributing
We were ecstatic to hear the their ground breaking research
Impact Factor result when it was in CTI.
recently released on the 21st
June 2019. The 2018 Journal
Citation Reports showed an
incredible first Impact Factor for
CTI of 7.271!
This fantastic Impact Factor
placed our journal 22/158 in
the Immunology category, and
well above other immunology
journals such as Journal of
Clinical Immunology (4.128),
Oncoimmunology (5.333), Clinical
and Experimental Allergy (4.741),
European Journal of Immunology
(4.695), and the Journal of
Immunology (4.718).
ASI congratulates the CTI
Editorial Board on this
outstanding achievement.
ASI Members – don’t forget
about the fantastic benefits
of submitting your work to
CTI, including member-only
opportunities such as the
7
Clinical & Translational Immunology ASI NEWSLETTER SEPTEMBER 2019
Catch up on recent Special Features from Clinical & Translational Immunology, including:
CTI Special Feature on Endoplasmic Reticulum and Oxidative Stress in Immunopathology
Misfolded+
Protein
Increased+
Protein+load+
Special Feature Coordinator: Sumaira Z Hasnain
Endoplasmic reticulum (ER) stress and related molecular programs, which occur when proteins misfold
Microbial+
Endoplasmic, Products
e"
Reticulum,Stress
O2"
Cytokines
Infections
during biosynthesis in the ER, are important components of the pathophysiology of several diseases
Reactive+Oxygen+
including cancer, diabetes, inflammatory bowel disease and multiple forms of respiratory inflammation.
Despite this, our understanding of the molecular programs that regulate ER stress, ER-associated
Species Inflammation,+
Autophagy,+
Apoptosis
degradation pathways, oxidative stress and the unfolded protein response are limited. In this Special
Feature of Clinical & Translational Immunology, we highlight the complex relationship between cellular
stress pathways and inflammation and the potential strategies that could pave the way for specific drugs
designed to improve protein folding, manipulate the unfolded protein response to reduce inflammation
and restore homeostasis.
Page 29 of 31 Clinical & Translational Immunology
(July 2018)
1
2
3
4
5
CTI Special Feature on Genome-wide Association Studies and Immunity
6
7
8 CHROMOSOME
9
10
11
12
13
14
15
Special Feature Coordinator: Manuel Ferreira
16
17
Fo
18
19MULTIPLE HAPLOTYPES
20
rR
21 (containing GWAS SNPs)
22
23
GWAS SNP Causal variant
ev
24
This Special Feature of Clinical & Translational Immunology marks 10 years since genome-wide
25
iew
26
27
28 Other SNPs in linkage disequilibrium (LD)
29
30
including causal variant
On association studies (GWAS) were first applied to immune-related diseases. The five reviews cover
31
32
33
ly
34
35
36 Cases Controls
findings from ankylosing spondylitis, asthma, Crohn’s disease, multiple sclerosis and type-1
37
38
39
40
41
42
diabetes. Topics covered include a summary of genetic associations reported to date, the likely
43
44
45
46
Minor allele frequency
47
48
target genes underlying those associations, novel insights into disease aetiology, and challenges
49
50
51
52
53
54
55
and opportunities that will shape our field in the next 10 years.
56
57
58
59 Cases Controls
60
(June 2018)
CTI Special Feature on Microbiota and immune cell crosstalk:
dialogues across health and disease
Special Feature Coordinator: Erika Duan
The therapeutic potential of correcting microbiota dysbiosis has galvanised researchers and clinicians
alike. Immune cells can selectively sense and eliminate microbial species, interact within a local
microenvironment and migrate into the periphery or distal organs following co-ordinated activation.
This renders them as prime candidates in the endeavour to understand how a localised microbiome can
broadly influence organism health and disease susceptibility. Specific commensal microbes can induce
tolerogenic or tissue reparative immune cells to maintain organ health, whilst unintentional microbe
translocation can initiate disease pathology. Critically, bi-directional communication exists as certain
immune cell products can sequester microbial species. Since immune cell contributions to acute and
chronic diseases are extensively studied, insight into the mechanisms of immune cell and microbiota
crosstalk may provide new leads in the development of superior therapeutic agents. In this Special
Feature of Clinical & Translational Immunology, we present four reviews which address and summarise
the evidence for immune cell and microbiota crosstalk during different acute and chronic diseases.
(May 2018)
CTI Special Feature on Regulatory T cell heterogeneity
Special Feature Coordinators: Ajithkumar Vasanthakumar and Kirsten Ward Hartstonge
Distinguishing self from non-self is a unique feature of the immune system. While negative selection
rigorously eliminates auto-reactive T cells, the few cells that escape could trigger severe auto-immune
responses. Regulatory T cells (Tregs) however, keep these auto-reactive T cells and other inflammatory
T cells in check to preserve immune homeostasis. Paucity of Tregs leads to fatal autoimmunity in both
mice and humans. While most Tregs develop in the thymus, they adapt and populate multiple lymphoid
and non-lymphoid tissues. Besides suppressing auto-reactive T cells, Tregs also perform non-canonical
functions, which include tissue repair and regulation of organismal metabolism. Tregs therefore are
heterogeneous in their tissue localization and function. A small fraction of Tregs that differentiate from
19 - RM000283
conventional CD4+ T cells in the periphery further adds to this heterogeneity. In this special feature,
we have collated reviews from experts to highlight Treg cell heterogeneity from the perspective of their
origin, phenotype, tissue localization, function and the complexity in regulation of these features.
(March 2018)
Start reading at www.wileyonlinelibrary.com/journal/cti
8
CTI: SPECIAL FEATURE ON CELL AND GENE THERAPY ASI NEWSLETTER SEPTEMBER 2019
SPECIAL FEATURE ON CELL
AND GENE THERAPY
CLINICAL & TRANSLATIONAL IMMUNOLOGY
PAUL BEAVIS AND PHILLIP DARCY, Special Feature Coordinators
Adoptive cellular immunotherapy increasing the function, trafficking
These results have led to recent
FDA approval of two CAR T cell
involving the transfer of and safety of CAR T cell therapy
autologous chimeric antigen and for broadening the utility
receptor (CAR) T cells has resulted of this specialised form of products for the treatment of
in remarkable responses in immunotherapy for treatment CD19+ ALL and non-Hodgkin
relapsed B cell malignancies such of cancers that have failed lymphoma.
as acute lymphoid leukaemia conventional treatments.
(ALL), often resulting in long-
term remission in these patients.
These results have led to recent
FDA approval of two CAR T cell
products for the treatment of
CD19+ ALL and non-Hodgkin
lymphoma. However, the broad
use of this type of therapy for
other cancers, in particular solid
tumors, has been precluded
by both intrinsic and extrinsic
factors. This includes the
immunosuppressive tumor
microenvironment, poor
trafficking and infiltration of
CAR T cells into the tumor site
and heterogenous expression of
antigen on the tumor cells.
In this Special Feature of Clinical
& Translational Immunology, we
have invited leading experts in
the adoptive immunotherapy
IMAGE GENERATED BY ALEXANDER J DAVENPORT AT THE PETER MACCALLUM CANCER
field to discuss recent innovative
CENTRE, MELBOURNE, AUSTRALIA.
developments for potentially
9
48th Annual Scientific ASIMeeting of 2019
NEWSLETTER SEPTEMBER
The Australian and New Zealand
Society for Immunology
Adelaide Convention Centre, South Australia
8 - 12 December 2019
www.asi2019.org SAVE
THE
The Organising Committee cordially invite
you to participate in the 48th Annual Scientific 8
DATE
-12 D
Meeting of The Australasian Society for ece
ADEL mber 20
Immunology taking place from 8-12 AIDE 1
, SA 9
December 2019 in Adelaide, South Australia.
The Conference aims to provide
another innovative and dynamic scientific program.
We are putting together a varied and balanced program
spread over 5 days to showcase the best immunological research from
Australia and around the world. With a wide-range of topics from tumour
immunology, inflammation, autoimmunity, infectious disease, translational
immunology and more, we will ensure there is something for everyone.
Preparations are well underway and we anticipate an intellectually
Key Dates challenging time, as well as an enjoyable opportunity to experience
South Australia and its unique environment. The Organising Committee
Registration Open
are preparing an engaging social program to give you a flavour of South
3 May 2019
Australian culture and cuisine.
Call for Abstracts Open Adelaide is a modern, dynamic, vibrant and lifestyle city with direct access
3 May 2019 to Australia’s best wine regions and stunning scenery, making it an ideal
destination for pre and post-Conference touring. It is home to world-class
Call for Abstracts Close
restaurants, a diverse nightlife, stylish shops and more.
30 August 2019
We look forward to welcoming you to Adelaide!
Abstract Notifications
27 September 2019 Adelaide Convention Centre
The Adelaide Convention Centre is conveniently located in the heart of
Early-bird / Presenter Registration Close
the city centre and nestled within the beauty of the Riverbank Precinct,
4 October 2019
surrounded by parklands and the River Torrens.
Special Interest Group Workshops Close proximity to the medical hub, entertainment, cultural and sport
8 December 2019 precinct, the Centre is a short walk to international and boutique hotels
and accommodation. Public transport, the Adelaide Railway Station and a
ASI2018 Conference
taxi ramp are on our doorstep.
8 – 12 December 2019
10 10ASI ADELAIDE 2019 48th Annual Scientific Meeting
ASI NEWSLETTER of 2019
SEPTEMBER
The Australian and New Zealand
Society for Immunology
Adelaide Convention Centre, South Australia
8 - 12 December 2019
www.asi2019.org SAVE
THE
48th Annual Scientific Meeting of
The Organising Committee cordially invite
you to participate in the 48th Annual Scientific 8
DATE
-12 D
ece
The Australian and New Zealand
Meeting of The Australasian Society for
ADEL mber 20
Immunology taking place from 8-12 AIDE 1
, SA 9
Society for Immunology
December 2019 in Adelaide, South Australia.
The Conference aims to provide
another innovative and dynamic scientific program.
Adelaide Convention Centre, South Australia
We are putting together a varied and balanced program
8 - 12 December 2019 spread over 5 days to showcase the best immunological research from
Australia and around the world. With a wide-range of topics from tumour
www.asi2019.org Sunday 8th December
SAVE
immunology, inflammation, autoimmunity, infectious disease, translational
immunology and more, we will ensure there is something for everyone.
THFeaturing
Preparations are well underway and we anticipate an intellectually
Key Dates
Workshops E DA our
challenging time, as well as an enjoyable opportunity to experience
TE
The Organising Committee cordially inviteSouth Australia and its unique environment. The Organising Committee
Registration Open
are preparing an engaging social program to give you a flavour of South
you3to participate in the 48th Annual Scientific
Special Interest Groups!
May 2019 8-12
Australian culture and cuisine.
Meeting of The Australasian Society for Dece
Call for Abstracts Open ADEdynamic,
Adelaide is a modern, mvibrant
ber 2 and lifestyle city with direct access
to Australia’s best wine L 0 9
AIDand E, SA 1scenery,
Immunology
3 May 2019 taking place from 8-12 regions stunning making it an ideal
December 2019 in Adelaide, South Australia.
destination for pre and post-Conference touring. It is home to world-class
Call for Abstracts Close
restaurants, a diverse nightlife, stylish shops and more.
The30Conference
August 2019 aims to provide Postgraduate Workshop
another innovative and dynamic scientific We look forward to welcoming you to Adelaide!
program.
Abstract Notifications
27 September 2019 Adelaide Convention Centre
We are putting together a varied and balanced program
SIG Workshop 1: Mucosal
The Adelaide Convention Immunology
Centre is conveniently located in the heart of
spread over/ Presenter
Early-bird 5 days Registration
to showcaseClosethe best immunological research from
the city centre and nestled within the beauty of the Riverbank Precinct,
4 October 2019
Australia and around the world. With a wide-rangesurroundedof bytopics from
parklands and tumour
the River Torrens.
immunology, inflammation, SIG
autoimmunity,
Special Interest Group Workshops Workshop
infectious 2:
disease,Tumour Immunology
translational
Close proximity to the medical hub, entertainment, cultural and sport
8 December 2019 precinct, the Centre is a short walk to international and boutique hotels
immunology and more, we will ensure there is something for everyone.
and accommodation. Public transport, the Adelaide Railway Station and a
ASI2018 Conference
Preparations SIG
are well underway and
8 – 12 December 2019
Workshop
we anticipate 3: doorstep.
Infection & Immunity
anonintellectually
taxi ramp are our
challenging time, as well as an enjoyable opportunity to experience
South Australia and its unique environment. The Organising Committee
SIG Workshop 4: Stromal Immunology
are preparing an engaging social program to give you a flavour of South
Australian culture and cuisine.
SIG and
Adelaide is a modern, dynamic, vibrant Workshop
lifestyle city5: Systems
with Immunology
direct access
to Australia’s best wine regions and stunning scenery, making it an ideal
SIG Workshop
destination for pre and post-Conference 6: Clinical
touring. It is home Immunology
to world-class
restaurants, a diverse nightlife, stylish shops and more.
We look forward to welcoming you to Adelaide!
Adelaide Convention Centre
The Adelaide Convention Centre is conveniently located in the heart of
ose
the city centre and nestled within the beauty of the Riverbank Precinct,
surrounded by parklands and the River Torrens.
Close proximity to the medical hub, entertainment, cultural and sport
precinct, the Centre is a short walk to international and boutique hotels
11
and accommodation. Public transport, the Adelaide Railway Station and a
taxi ramp are on our doorstep.WOMEN’S INITIATIVE NEWS ASI NEWSLETTER SEPTEMBER 2019
WOMEN’S INITIATIVE NEWS
KYLIE QUINN, Women’s Initiative Coordinator
kylie.quinn@rmit.edu.au
In this newsletter, I want to beginning of the Annual Meeting, from the Centre for Cancer
highlight two initiatives that so that everyone will have lots Biology in Adelaide, who has been
you can get involved with: the of opportunities to put her helping to organise the session!
Women’s Initiative Session at the suggestions to good use!
A New and Improved Women
2019 Annual Meeting and the ASI
So, if you are keen to proactively Speakers Database
Women Speakers Database.
support gender equity and The new ASI website is looking
Women’s Initiative Session at the diversity within ASI and keen to great – go check it out if you
ASI Annual Meeting learn about what works, please haven’t already. Your ASI profiles
At the upcoming 2019 Annual make sure to register and join us have also moved online and one
Meeting in Adelaide, we will have at this event- on the first day of of the big advantages to our
a Women’s Initiative Session. the conference during morning new system is that you can load
tea (10-11 am). your ASI profile directly into the
Everyone is welcomed but the
And many thanks to Tessa Gargett Women Speakers database.
session arose because a number
of men within ASI got in contact
to say they wanted to act to
support gender equity initiatives.
The aim of the session is therefore HOW TO BE INCLUDED IN THE WOMEN SPEAKERS
to give all ASI members, but DATABASE?
particularly men, some evidence-
If you want to be included on the database, follow these few simple
based tools and practices that
steps:
folks can use within ASI and in
daily life. 1. Log into your ASI member profile via the ASI website (www.
immunology.org.au/members/)
We have Prof Karen Farquharson
(University of Melbourne) 2. Fill out your details (making sure to select your “Discipline field
joining us to lead the session. of interests”) and then scroll to the bottom of the “Profile 2” tab.
Prof Farquharson is an expert in You can tick a box there to load your profile onto the Women
evidence-based practices that Speakers database, but don’t forget to scroll a bit further down
support equity and diversity. to fill out the rest of your profile!
We’ve lined the session up at the 3. If you have accounts for Google Scholar, ResearchGate, LinkedIn
or ORCID or an institutional website, these can all be added to
your profile.
If you are keen to proactively
support gender equity and You can also upload a bio picture and a brief biography to highlight
diversity within ASI and keen to
your skills and achievements. I highly encourage you to personalise
your profile and we have some great looking profiles on there
learn about what works, please already if you need some inspiration.
make sure to register and join us.
12WOMEN’S INITIATIVE NEWS ASI NEWSLETTER SEPTEMBER 2019
A key benefit of the database is
If you are looking to increase women in STEM.
that you can now update your
details at any time. If you move,
your visibility, these are some Scimex have the “Find and Expert”
have new research interests or great resources to do it. database (https://www.scimex.
org/find-an-expert), which aims
skills, or new accolades, just
to connect science journalists and
change it on your ASI profile and If you are keen to be featured on scientific experts in Australia and
the database will be updated. the database, please make sure to New Zealand, with a lot of great
We envision that this database update your profile before then. women on this website.
will be used in many different Fortunately, ASI is not alone in If you are looking to increase your
ways- conference and event promoting women in science with visibility, these are some great
organisers looking for a speaker access to databases: resources to do it.
or panellist; media outlets
looking for expert commentary; The Australian Academy of Finally, ASI members can now
scientific journal editors looking Science has recently launched also access an online Membership
for people to invite for articles “STEM Women” (https://www. Directory under your profile that
or reviewing; educators looking stemwomen.org.au), which is enables you to contact all other
for an expert to communicate an online database of women in ASI members. If you are looking
to their classes; policy makers STEM in Australia. for a diverse array of women
looking for experts. To enhance 500 Women Scientists website and men in our community for
the visibility of the database, we has “Request a Women Scientist” speaking or other opportunities,
will circulate a description and (https://500womenscientists.org/ this is a great resource too.
link to the database to a number request-a-scientist), which is an
of outlets on the 1st October 2019. international online database of
13GORDON ADA SENIOR AWARD RECIPIENT 2019 ASI NEWSLETTER SEPTEMBER 2019
GORDON ADA SENIOR
AWARD RECIPIENT 2019
DR NATALIE BORG
Immunity and Immune Evasion Lab, Depart-
ment of Biochemistry and Molecular Biology,
Monash University
natalie.borg@monash.edu
After finishing my undergraduate CSIRO in Parkville and I was
degree, I admittedly started The highlight of my PhD was enrolled through the University of
my honours year at RMIT with being the first to determine the Melbourne under the supervision
much hesitation. I wasn’t sure structure of the HN protein from of Jenny McKimm-Breschkin
what I wanted to do and so a hPIV3, and this in turn led to a and Margot Anders. The project
year’s experience in the wet-lab
structure of HN with RELENZA® was to study the structure and
seemed like a good move for function of a surface glycoprotein
future employment. My project called HN (haemagglutinin-
involved using phage display I learnt quickly to ask the right neuraminidase) from human
to identify influenza epitopes, questions of the right people. parainfluenza virus type 3
and this is where my passion for After honours I was certain a (hPIV3). This project captured
studying viruses began. I found PhD wasn’t for me…and then my interest as it enabled me to
my honours year tough due to I started one. In between my continue my love for viral research
the steep learning curve, but as two extremes I had stumbled whilst exposing me to X-ray
the year progressed I became across an advertisement for a crystallography. The highlight of
more persistent, resilient and PhD student in the newspaper. my PhD was being the first to
resourceful. Most importantly, The position was located at the determine the structure of the
HN protein from hPIV3, and this
in turn led to a structure of HN
with RELENZA® (Figure 2), the
influenza virus neuraminidase
inhibitor, bound to its active
site. The study provided insights
into the receptor-binding and
neuraminidase functions of HN,
and highlighted to me the power
that visualising a molecule holds
towards understanding how it
works.
Following on from my PhD
I joined Jamie Rossjohn’s
laboratory at Monash University.
I wanted to continue using X-ray
crystallography as a study tool
FIGURE: THE STRUCTURE OF HN IN COMPLEX WITH RELENZA® and this position provided the
14GORDON ADA SENIOR AWARD RECIPIENT 2019 ASI NEWSLETTER SEPTEMBER 2019
perfect opportunity to do so,
as the Protein Crystallography
Unit had just been established
at Monash University. My
research focus was to understand
the cornerstone of adaptive
immunity - how T Cell Receptors
(TCRs) recognise peptide
antigens displayed by Major
Histocompatibility Complex
(MHC) molecules. This research
later extended to understanding
how Natural Killer T (NKT) cells
recognise glycolipid antigens
displayed by MHC-like molecules.
A major highlight was being
one of the first ever to visualise
how TCRs recognise glycolipid
antigens – this was significant
because at the time we had
only ever visualised how TCRs
recognise peptide antigens. It MY RESEARCH TEAM. LEFT BACK - MICHELLE AUDSLEY, RIGHT BACK - SARAH ATKINSON;
was predicted that TCRs might FRONT LEFT – JACINTA WUBBEN, FRONT CENTRE – NATALIE BORG, FRONT RIGHT – MELISSA
recognize glycolipid-antigens SWEENEY.
in a similar way to peptide-
antigens, but our structure proved
otherwise. An added bonus was Now faced with finding my own treatment options or emerging
that the structure was published research niche, I came full circle drug resistance. My research
in Nature, and received a write and combined my love of X-ray vision is to advance knowledge of
up in Nature ‘News and Views’. crystallography with my previous host- and microbial-dependent
The article continues to attract research exposures. Although regulation of innate immunity,
interest as since 2007 it has I am now focused on innate and build on this to enable new
accrued over 530 citations. I have immunity, my major research strategies to combat microbial
very fond memories of this time. interests include host-pathogen infections. To this end, the biggest
interactions and understanding highlight of my career so far
My PhD and post-doc outputs
the role pathogens play in has been the road to translating
blocking or manipulating host an arm of our basic academic
My research vision is to proteins to aid their replication. research. This venture is in
advance knowledge of host- and I also have an interest in the collaboration with David Jans, and
microbial-dependent regulation role of ubiquitination and has been supported financially
of innate immunity, and build on
nucleocytoplasmic transport in by Monash University, BioCurate
regulating the function of host/ and Therapeutic Innovation
this to enable new strategies to pathogen-derived proteins. To Australia. I’m very much enjoying
combat microbial infections. address our research questions this journey, and observing
we use a diverse portfolio of the stark differences between
structural/biophysical tools academic and translational
culminated in the award of an
combined with high-resolution research. My first exposure to the
NHMRC Peter Doherty Fellowship,
imaging and cell-based infectious translational process has re-jigged
and later I received an NHMRC
assays. My group started with my way of thinking about basic
Career Development Award and
a single PhD student, but research, and I hope to spin-off
a L’Oréal Australia for Women in
has steadily expanded, and I new translational projects in the
Science Fellowship. I used these
was awarded an ARC Future future. My ultimate aim is to
fellowships to launch my own
Fellowship during this time. develop therapeutics that will
laboratory within the Department
make a lasting contribution to
of Biochemistry and Molecular We are in an era where infectious
human health.
Biology at Monash University. disease remains a significant
global challenge due to a lack of
15JARED PURTON AWARD RECIPIENT ASI NEWSLETTER SEPTEMBER 2019
JARED PURTON
AWARD RECIPIENT
DR LUCY SULLIVAN
The Peter Doherty Institute for Infection and
Immunity, Department of Microbiology and
Immunology, University of Melbourne
lcsull@unimelb.edu.au
I completed my Bachelor of
My current research investigates from the Transplantation Society
Science (Honours) and PhD at the of Australia and New Zealand
University of Adelaide. My early
the immune system following (TSANZ). My ability to link
research focused on comparative lung transplantation with a focus basic laboratory research with
aspects of lung physiology and on defining parameters that can translational clinical activities
during this time I developed a improve survival rates. saw me convening the 2018
keen interest in immunity. This Annual Scientific Meeting of
prompted a change in direction the Transplantation Society
A major focus of my post-
for my postdoctoral research of Australia and New Zealand
doctoral studies focused on
where I joined the lab of Professor (TSANZ). I am currently chair
understanding how viruses
Andrew Brooks at the University of the Scientific Program
shape immune responses
of Melbourne. and Education Committee
during lung transplantation.
of TSANZ and a member
Through my work at the
of the Transplantation and
Brooks lab, I made a significant
Immunogenetics Research
contribution to understanding
Advisory Committee. I am also
the role of natural killer (NK)
a strong advocate for women
cells in immunity to viruses
in medical research, being
following lung transplantation. In
an executive member of the
recognition of my contribution
Women in Science Parkville
to transplantation research, I was
Precinct (WiSPP) group, where
commended with a joint Research
we are establishing programs to
Fellowship at The Alfred Hospital
promote gender equity in medical
with the Lung Transplant Service
research.
and with the Peter Doherty
Institute at The University of My current research investigates
Melbourne in 2017. Since then the immune system following
I have received several awards lung transplantation with a focus
during my career, including an on defining parameters that
NHMRC Peter Doherty Fellowship, can improve survival rates. We
NHMRC Career Development have several active and ongoing
Award, a University of Melbourne projects focused on reducing
Research Fellowship and the rejection and controlling infection
DR LUCY SULLIVAN, JARED PURTON
AWARD RECIPIENT Josette Eris Memorial Award following lung transplantation.
16JARED PURTON AWARD RECIPIENT ASI NEWSLETTER SEPTEMBER 2019
FIGURE : MY RESEARCH FOCUSES ON THE CONTROL OF REJECTION AND INFECTION FOLLOWING LUNG TRANSPLANTATION. LUNG
TRANSPLANTATION IS A LIFE-SAVING THERAPY FOR PEOPLE WITH END-STAGE LUNG DISEASE. HOWEVER, LOGISTICAL AND TIME
CONSTRAINTS DICTATE THAT LUNG-TRANSPLANT RECIPIENTS ARE NOT HLA-MATCHED TO THEIR ORGAN DONOR, RESULTING IN THE
REQUIREMENT FOR LIFE-LONG IMMUNOSUPPRESSION. FIGURE BY DR PHILIPPA SAUNDERS.
Left panel: Donor-recipient mismatches result in the stimulation of Right panel: Post-transplant immunosuppression, required to
cellular (T cell) and humoral (antibody) alloreactivity. Whilst T cell prevent rejection, results in impaired ability to control infections.
alloreactivity is an established risk factor for rejection, there is an Cytomegalovirus (CMV) is the most significant pathogen causing
increasing recognition of anti-HLA donor specific antibodies (DSA) post-transplant complications. Our research investigates the
against the lung allograft also contributing to rejection. One stream immune cells that control CMV following transplantation, with a
of our research focuses on the identification and the mechanisms of focus on NK and gd T cell subsets. Our study aims to ultimately
DSA formation and determining the role of natural killer (NK) and gd guide diagnostic tests to predict CMV infection and to harness
T cells as effectors of antibody-mediated rejection. immune cells for cellular therapy in recipients with CMV disease.
17JARED PURTON AWARD RECIPIENT ASI NEWSLETTER SEPTEMBER 2019
have future utility in novel cell refining pilot experiments with
therapy for post-transplant CMV the objective of commercially
disease. We are also developing marketing an assay that aims to
diagnostics to predict recipients improve the clinical management
who are at most risk of CMV of transplant patients. The Jared
disease. (Figure 4) Purton Award allowed present
this research at ISHLT, helping
With the help of the Jared
to raise my research profile at
Purton Award, in April 2019 I
this crucial point in my career.
attended the annual meeting
With the help of the Jared Purton
of the International Society for
Award, I have established new
Heart and Lung Transplantation
collaborations that will enable
(ISHLT) in Orlando, Florida.
me to extend our research into
This is the world’s largest
multiple lung transplant centres.
lung transplantation meeting
Most importantly, this award
with attendance by clinicians,
assisted me towards my ultimate
DR LUCY SULLIVAN, JARED PURTON scientists and commercial
goal: to extend the lives of
AWARD RECIPIENT companies. We are currently
transplant recipients.
One project aims to identify and
understand the mechanisms of
antibody-mediated destruction
of the lung allograft, for the
purpose of ultimately designing
targeted therapies to prevent
rejection. In an exciting new
development in this project we
now believe that the antibodies
that are produced by the donor’s
immune cells can also contribute
to antibodies present in transplant
recipients. We will continue to
pursue this area of research as
With the help of the Jared
Purton Award, I have established
new collaborations that will
enable me to extend our
research into multiple lung
transplant centres.
it has the potential to cause a
paradigm shift in the way we
think about antibodies that can
damage a transplanted lung.
Another project is focused on the
control of cytomegalovirus (CMV)
following lung transplantation.
CMV disease is a major problem
following transplantation and
uncontrolled CMV replication can
result in organ loss and death. Our
research in this area has identified
subsets of immune cells that
18Immunology ASI NEWSLETTER SEPTEMBER 2019
& Cell Biology
the flagship journal of the Australian and
New Zealand Society for Immunology (ASI)
2018 Impact Factor 3.947
Immunology & Cell Biology is an international peer-
v
Immunology
reviewed journal, with a reputation built on more
97 97
6 6
& Cell publishing.
than 90 years of innovative Biology Areas that Immunology
Immunology & Cell Biology
Immunology & Cell Biology
are covered includeWKHȵDJVKLSMRXUQDORIWKHb$XVWUDOLDQDQG
but are not limited to:
1HZ=HDODQG6RFLHW\IRUΖPPXQRORJ\b $6Ζ & Cell Biology
• Cellular immunology
&DWFKXSRQUHFHQW6SHFLDO)HDWXUHV
www.wileyonlinelibrary.com/journal/icb Volume 97‚ Issue 6‚ July 2019
IURPImmunology & Cell Biology,LQFOXGLQJ
• Innate and adaptive immunity
• Immune responses to pathogens
Volume 97
Volume 97
• Tumour immunology
Number 6
Number 6
Special Feature on Special Feature on MAIT cells Special Feature on Immune
Extracellular Vesicles and The July 2018 issue contains a Special homeostasis in health and
• Immunopathology
Immune Modulation Feature on MAIT cells. Mucosal Associated disease
pages 519–610
pages 115–236
Invariant T (MAIT) cells are an innate-like
The August 2018 issue contains a Special The May/June 2018 issue contains a
T-cell population that have attracted
Feature on Extracellular Vesicles and Special Feature on Immune homeostasis
increasing amounts of attention, especially
Immune Modulation. There is a variety in health and disease. This series
LQWKHODVWIHZ\HDUVVLQFHWKHLUVSHFLȴFLW\
of extracellular vesicles (EV) produced explores the mechanisms that maintain
• Immunotherapy
KDVEHHQGHȴQHGΖQKXPDQVWKHVHFHOOV
by cells, including but not limited to homeostasis across a variety of key
are very abundant, notably in organs such
exosomes, microvesicles and apoptotic immune cell lineages. Important themes
as the liver, but also in blood, so they are
vesicles. Once thought of as a way to include how these mechanisms adjust
UHDGLO\LGHQWLȴHGDQGVWXGLHGDQGZHKDYH
jettison cellular waste, it has become with challenges as diverse as infection,
also learned a lot from animal models.
apparent that EV are an integral cancer or drug exposure to maintain
In this series of reviews, we discuss the
• Immunogenetics
compartment of a cell, albeit one that homeostasis, or the adaption to chronic
GHYHORSPHQWRI0$Ζ7FHOOVDQGWKHȴQH
can act at a distance to transmit conditions that impose new set-points to
details of their T-cell receptor recognition
intercellular messages. This series of limit tissue damage. This Special Feature
of MR-1 and the ligands it binds. We also
articles looks particularly at how blood also explores the prospects for translating
discuss the functions of these cells in a
and immune cell function are regulated these mechanistic insights in each of the
variety of settings, taking into account the
by EV. From extracellular antigen main immune lineages into new targets
• Immunological studies in humans
emerging data on their diverse triggering
presentation, through to the modulation for immune disorders. Immunology & Cell
PHFKDQLVPV7KLVȴHOGLVGHYHORSLQJ
of immune activity by pathogens, Biology thanks the coordinators of this
rapidly and we hope to capture these new
parasites and pregnancy, cancer cell Special Feature – Daniel Gray and Nick
advances and the questions they pose
LPPXQHHYDVLRQDQGWKHHHFWRI Huntington – for their planning and input.
and model organisms
in this set of reviews. Immunology & Cell
chemotherapy on blood cell function, EV
Biology thanks the coordinators of this
play a critical role in cell communication.
Special Feature – Daniel Pellicci and Paul
Immunology & Cell Biology thanks the
Klenerman – for their planning and input.
coordinator of this Special Feature –
Melanie McConnell – for her planning
and input.
19 - RM000283
Submit your next manuscript to Immunology Find out more by visiting the journal’s homepage here:
& Cell Biology and enjoy these benefits of
http://www.wileyonlinelibrary.com/journal/icb
July 2019
July 2019
Or access it by scanning this code
publishing with Wiley
IMCB_v97_i6_cover.indd 1 25-Jun-19 11:57:16 AM
Find out more by visiting the journal’s homepage here:
http://www.wileyonlinelibrary.com/journal/icb
Or access it by scanning this code
19Immunology ASI NEWSLETTER SEPTEMBER 2019
& Cell Biology
the flagship journal of the Australian and
New Zealand Society for Immunology (ASI)
Catch up on recent Special Features
from Immunology & Cell Biology, including:
Special Feature on Immunological Memory
The August 2019 issue of Immunology & Cell Biology contains a Special Feature on Immunological Memory.
The term “Immunological Memory” refers to the phenomenon that, after an initial exposure, immune mechanisms
respond more vigorously to subsequent exposure to a pathogen. This is fundamental to the concept of immunity;
it is a cornerstone many immune-based therapies and it has been documented in human history for thousands of
years. However, there remains much to be learned about the basic biology underlying this phenomenon. This series
of articles explores recent advances in immunological memory, by examining our current understanding of CD4 T
cell memory differentiation pathways, evaluating the impact of the microbiome on developing B and T cell memory
and exploring the role of metabolism in control of memory cell development. The articles also highlight how our
understanding of the basic biology of immunological memory can be used to refine the design of immunotherapies,
including vaccines and cell-based cancer therapies. Finally, several articles explore the broadening definition of
immunological memory, with an exploration of trained immunity and virtual memory cells. Immunology & Cell Biology
thanks the coordinators of this Special Feature – Joanna Kirman, Kylie Quinn and Robert Seder – for their planning
and input.
Special Feature on Primary Immunodeficiencies
The April 2019 issue contains a Special Feature on Primary Immunodeficiencies. Inborn errors of immunity,
or primary immunodeficiency disorders (PID), are monogenic diseases of the immune system. These affections
give rise to complex diseases with a wide range of susceptibility to infections. The advent of next-generation
sequencing has ushered in a Golden Age of PID research. The number of genes identified as responsible for PID
has been rapidly rising, with a new PID gene identified on average every week for the past 10 years. Despite the
recent explosion of knowledge, 90% of the estimated 3000 PID genes have yet to be studied. This Special Feature
discusses recent advances in PID research, and what it means for our understanding of human immunology.
Immunology & Cell Biology thanks the coordinators of this Special Feature – Adrian Liston & Stephanie Humblet-
Baron – for their planning and input.
COPD human lung live
Special Feature on Macrophages in Tissue Repair
precision cut lung slice
EPCAM- Green
CD206- Magenta The March 2019 issue of Immunology & Cell Biology contains a Special Feature on Macrophages in tissue repair.
In the late 18th century, Metchnikoff proposed the ‘phagocytosis theory’ in which he controversially placed
the contribution of macrophages to organismal biology as being of even greater importance than their role in
bactericidal defence. His view still prevails today, with macrophages appreciated as playing a fundamental role in
the process of tissue repair. The present series of articles explores recent advances in this area, highlighting the
importance of macrophage heterogeneity, plasticity, tissue specificity, activation status and cellular metabolism
on the outcome of tissue repair. Finally, in a broader view of the repair process, the role of neutrophils as well as
eicosanoids as supporting macrophage migration and polarisation is discussed. Immunology & Cell Biology thanks
the coordinators of this Special Feature – Tiffany Bouchery and Nicola Harris – for their planning and input.
19 - RM000283
Find out more by visiting the journal’s homepage here:
http://www.wileyonlinelibrary.com/journal/icb
Or access it by scanning this code
20ASI-ADVANCED IMMUNOLOGY SCHOOL ASI NEWSLETTER SEPTEMBER 2019
ASI-ADVANCED
IMMUNOLOGY SCHOOL
22-25TH JULY, 2019, ILUKA RETREAT, RAWSON, VICTORIA
SARAH DART, Immunology and Microsurgery Group,
University of Western Australia
STEVEN HEATON, Department of Biochemistry & Molecular Biology,
Monash University
On July 22nd-25th, ASI hosted
the inaugural Advanced
Immunology School at Iluka
Retreat in Mornington Peninsula,
Victoria. There was genuine
warmth on display that cut
through the winter air, leading to
new friends and great discussions
between early career researchers
and established experts in the
field.
BONDING OVER A MORNING COFFEE
Centred on the theme ‘Immune
Life’, we heard from some
of Australia’s best scientists
through expert seminars, panel
Early career researchers had dump channels”. Dr Joanne Reed
the chance to present their
also reflected on some great
discussions and skills workshops. life lessons we can borrow from
Early career researchers had the latest research, all the while immunology, including “learn
chance to present their latest being encouraged to challenge through positive and negative
research, all the while being dogma, discover our passion and feedback”, and “build diverse and
encouraged to challenge dogma,
consider what type of scientist collaborative teams”.
discover our passion and consider
what type of scientist we are.
we are. The unique opportunity to
present work to all delegates
Among the most memorable A/Prof Kim Jacobson, reminding without judgement for prizes
advice in crafting our own us to “be your own FACS Aria; allowed us to present in a relaxed
‘Immune Life’ were the words of sort advice into collection or environment and get to know
21ASI-ADVANCED IMMUNOLOGY SCHOOL ASI NEWSLETTER SEPTEMBER 2019
a great opportunity to meet
other early career researchers
in immunology, forging life-
long friendships and potential
future collaborations. Hopefully
this will be the first of many
Advanced Immunology Schools
and we encourage all early career
researchers to watch this space
in 2020!
Thank you to the organising
committee: Susanne, Odilia,
Jess and Nick, for this
wonderful initiative, and to the
subcommittees for all their help
in making the event possible.
A huge thank you also to the
AUDIENCE PARTICIPATION WAS THE NAME OF THE GAME
inspiring faculty team for their
advice, guidance and expertise.
others at the School, to find
overlapping themes, techniques
or areas of interest to discuss
over our next meal. Throughout
the week we had the opportunity
to meet each and every person
in our cosy camp group of
58, allowing for many great
conversations.
Hopefully this will be the first
of many Advanced Immunology
Schools and we encourage all
early career researchers to
watch this space in 2020!
In true camp style, our evenings
were filled with (immunology-
related) fun including quizzes,
campfires and the lab Olympics,
during which we got to see
just how good some of our
‘immunology experts’ were at
filling tip boxes (with cryogloves
on, because, who doesn’t fill tip
boxes like that?).
Overall, the Advanced
Immunology School was a
wonderful week, mixed with
lots of learning and discussing
of immunology. It was also
22POSTER SHOWCASE: DOI 2019 ASI NEWSLETTER SEPTEMBER 2019
POSTER SHOWCASE: DOI 2019
GABRIELA KHOURY, DOI Coordinator
Gabriela.khoury1@gmail.com
Angelica Lau, Newsletter Editor
newsletter@immunology.org.au
Students were encouraged to put together a poster to explain their research
project in the manner of communicating their scientific work to the public during
Day of Immunology. These posters were on display during the public lectures
throughout DoI and the public voted on their favourites across continent! Here is a
compilation of the wonderful work these students have made and they look great!
29TH APRIL
DAY OF
AUSTRALIA AND
NEW ZEALAND
IMMUNOLOGY
23POSTER SHOWCASE: DOI 2019 ASI NEWSLETTER SEPTEMBER 2019
www.DoIdailynews.com.au
DoI News FRIDAY, MAY 3, 2019 DoI ISSUE
DoI2019 BREAKING NEWS: SCIENTISTS
DICOVER LINK BETWEEN MOUSE SURVIVAL
AND MOULDY HARD CHEESE Xavier Sng
I had two kinds of mice in my house and
they behaved just like the cells I study -
CD8 T cells!!
Mice depend on Mouldy Hard Cheese
(MHC) for survival but each mouse will only
snack on one type of cheese- leading to the
two kinds of mice: One that likes Gouda and Xavier Sng is a 3rd year
one that likes Blue Vein. PhD student in Prof.
Nicole La Gruta's lab at
Monash University, co-
supervised by Dr. Kylie
Quinn, with a long-
standing interest in CD8 T
cell biology.!
His research focuses onto
how MHCI gene dosage
When one cheese is removed, mice that dictates the level of MHCI
depend on that cheese disappeared expression and delimits
entirely, but the number of mice that the size and quality of
depend on the other cheese stays the resulting naive CD8 T cell
same. I was surprised since mice are population in the
notorious for proliferating to fill any periphery. This study has
available space! significant implications for
the composition of naive
CD8 T cell populations in
individuals with diverse
haplotype.
When I halved the amount of
either cheese, half of the mice that
depend on that cheese
disappeared! The mice that
survived were highly competitive
for their cheese- oh it was brutal!
What does this mean?
Given that the type and amount of cheeses limit
the type and number of mice (CD8 T cells), my
study of my mouse infestation gives us some
basic rules for how diversity and amount of Mouldy
Hard Cheese (MHC, up to six different varieties!)
shapes our mouse population (CD8 T cell pool).
FIGURE 1: WINNING POSTER BY XAVIER SNG
24You can also read
