JCEM THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Page created by Mike Davidson
 
CONTINUE READING
JCEM THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Downloaded from https://academic.oup.com/jcem/issue/106/3 by guest on 25 April 2021
                 ENDOCRINOLOGY
                 & METABOLISM
                 THE JOURNAL
                 OF CLINICAL

                 JCEM
    NUMBER 3
    VOLUME 106
    March 2021

                                             March 2021               VOLUME 106               NUMBER 3
1
JCEM THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
2A  Contents                                                                               J Clin Endocrinol Metab, March 2021, 106(3):13A–20A

   JCEM
                                         THE JOURNAL
                                         OF CLINICAL
                                         ENDOCRINOLOGY
                                         & METABOLISM

                                                                                  PUBLICATIONS CORE COMMITTEE
                                                                                  Daniel I. Spratt, Chair
                                                                                  Amita Bansal

                                                                                                                                                            Downloaded from https://academic.oup.com/jcem/issue/106/3 by guest on 25 April 2021
                                                                                  Arthur Gutierrez-Hartmann
                                                                                  Smita Jha
                                                                                  George J. Kahaly
   MISSION STATEMENT OF THE ENDOCRINE SOCIETY                                     Ana Claudia Latronico
   We unite, lead, and grow the endocrine community to accelerate                 Zhenqi Liu
   scientific breakthroughs and improve health worldwide.                         Sue Moenter
                                                                                  Stephanie T. Page
   APRIL 2020 – MARCH 2021                                                        Matthew D. Ringel
                                                                                  Hironobu Sasano
   BOARD OF DIRECTORS                                                             Gary D. Hammer, Ex Officio (President)
   Gary D. Hammer, President                                                      Carol H. Wysham, Ex Officio (President-Elect)
   Carol H. Wysham, President-Elect                                               Dolores M. Shoback, Ex Officio (Secretary/Treasurer)
   E. Dale Abel, Immediate Past President
   Dolores M. Shoback, Secretary/Treasurer
   Henry Anhalt
   Richard J. Auchus
   Samantha F. Butts
   Ann Danoff
   Ghada El-Hajj Fuleihan
   Whitney S. Goldner
   Ruth A. Keri
   Kathryn A. Martin
   John D.C. Newell-Price
   Stephen M. Rosenthal
   Joy Y. Wu

   Jenny A. Visser, Ex Officio (Nominating Committee Chair)
   Lindsey S. Trevino, Ex Officio (Early Career Director)

    On the cover: Light micrograph of the interior lobe of a human pituitary gland. Credit: Michael Ross / Science Source

2A       https://academic.oup.com/jcem                                                                     J Clin Endocrinol Metab, March 2021, 106(3):2A
RESOURCES
   JOURNAL INFORMATION                                                              The current year and two previous years’ issues are available from Oxford
   The Journal of Clinical Endocrinology & Metabolism (Print ISSN 0021-             University Press. Previous volumes can be obtained from the Periodicals
   972X; Online ISSN 1945-7197) is published monthly (January–December) by          Service Company, 11 Main Street, Germantown, NY 12526, USA. E-mail:

                                                                                                                                                                   Downloaded from https://academic.oup.com/jcem/issue/106/3 by guest on 25 April 2021
   Oxford University Press, 2001 Evans Road, Cary, NC 27513-2009 USA, on            psc@periodicals.com. Email: psc@periodicals.com.
   behalf of its owner, the Endocrine Society, 2055 L Street NW, Suite 600, Wash-   Tel: +1-518-537-4700. Fax:+1-518-537-5899.
   ington, DC 20036 USA, Tel. +1-202-971-3636; publications@endocrine.org;
   endocrine.org.                                                                   CONTACT INFORMATION
                                                                                    Journals Customer Service Department, Oxford Journals, Great Clarendon
   SUBSCRIPTIONS
                                                                                    Street, Oxford OX2 6DP, UK. E-mail: jnls.cust.serv@oup.com.
   A subscription to The Journal of Clinical Endocrinology & Metabolism
                                                                                    Tel: +44-0-1865-353907. Fax: +44-0-1865-353485.
   comprises 12 issues. Prices include dispatch by Standard Air. Airmail rates
   are available on request. The Journal of Clinical Endocrinology &                In the Americas, please contact: Journals Customer Service Depart-
   Metabolism Advance Articles are papers that have recently been accept-           ment, Oxford Journals, 2001 Evans Road, Cary, NC 27513, USA.
   ed but have not yet been copyedited, typeset, or assigned to an issue.           E-mail: jnlorders@oup.com. Tel: +1-800-852-7323 (toll-free in USA/
   The Advance Article display is updated daily.                                    Canada) or +1-919-677-0977. Fax: +1-979-677-1714. In Japan,
                                                                                    please contact: USACO Corporation, Tokyo, Japan
   Annual Subscription Rate (Volume 106, 12 issues, 2021)
                                                                                    usaco.co.jp; import@usaco.co.jp; Tel. +81-3-3505-3256. For
   Institutional
                                                                                    Endocrine Society member subscriptions, please contact:
   FTEs 1 to 5,000 – Online-only access: £846/$1356/€1230
   FTEs 1 to 5,000 – Print and online: £1063/$1485/€1549                            the Endocrine Society, endocrine.org/store/journals; info@endocrine.org;
   FTEs 5,001 to 20,000 – Online-only access: £1012/$1620/€1471                     Tel. +1-888-363-6762 (US only) or +1-202-971-3646.
   FTEs 5,001 to 20,000 – Print and online: £1248/$1791/€1816                       METHODS OF PAYMENT
   FTEs 20,001 and above – Online-only access: £1325/$2121/€1927
                                                                                    Payment should be made: by cheque (to Oxford Journals, Cashiers
   FTEs 20,001 and above – Print and online: £1634/$2348/€2376
                                                                                    Office, Great Clarendon Street, Oxford, OX2 6DP, UK); by bank transfer
   Personal
                                                                                    [to Barclays Bank Plc, Oxford Office, Oxford (bank sort code 20-65-18)
   Print: £755/$1021/€854
                                                                                    (UK); overseas only Swift code BARC GB22 (GB£ Sterling Account no.
   Please note: UK£ rate applies to UK and Rest of World, except US and Cana-       70299332, IBAN GB89BARC20651870299332; US$ Dollars Account
   da (US$) and Europe (Eur€). There are other subscription rates available; for    no. 66014600, IBAN GB27BARC20651866014600; EU€ EURO Account
   a complete listing, please visit https://academic.oup.com/jcem/subscribe.        no. 78923655, IBAN GB16BARC20651878923655]; or by credit card
   Full prepayment in the correct currency is required for all orders.              (Mastercard, Visa, Switch or American Express).
   Payment should be in US dollars for orders being delivered to the USA
                                                                                    POSTAL INFORMATION
   or Canada; Euros for orders being delivered within Europe (excluding
   the UK); GBP Sterling for orders being delivered elsewhere (i.e., not            Periodicals Postage Paid at Cary, NC, and additional mailing offices.
   being delivered to USA, Canada, or Europe). All orders should be                 POSTMASTER: Send address changes to The Journal of Clinical Endo-
   accompanied by full payment and sent to your nearest Oxford Journals             crinology & Metabolism, Journals Customer Service Department, Oxford
   office. Subscriptions are accepted for complete volumes only. Orders are         University Press, 2001 Evans Road, Cary, NC 27513-2009.
   regarded as firm, and payments are not refundable. Our prices include
                                                                                    ENVIRONMENTAL AND ETHICAL POLICIES
   dispatch by Standard Air. Claims must be notified within four months of
   dispatch/order date (whichever is later). Subscriptions in the EEC may           Oxford Journals, a division of Oxford University Press, is committed to
   be subject to European VAT. If registered, please supply details to avoid        working with the global community to bring the highest quality research to
   unnecessary charges. Subscribers in Canada, please add GST to the pric-          the widest possible audience. Oxford Journals will protect the environment
   es quoted. Personal rate subscriptions are only available if payment is          by implementing environmentally friendly policies and practices wherever
   made by personal cheque or credit card, delivery is to a private address,        possible. Please see https://academic.oup.com/journals/pages/about_us/eth-
   and is for personal use only.                                                    ical_policies for further information on environmental and ethical policies.

J Clin Endocrinol Metab, March 2021, 106(3):5A                                                                          https://academic.oup.com/jcem       5A
RESOURCES
  DIGITAL OBJECT IDENTIFIERS                                                        editors and publishers cannot accept liability for damages arising from
  For information on DOIs and to resolve them, please visit www.doi.org.            any errors or omissions in the journal. Please inform the editors of any
                                                                                    errors.

                                                                                                                                                                        Downloaded from https://academic.oup.com/jcem/issue/106/3 by guest on 25 April 2021
  RIGHTS AND PERMISSIONS
  For information on how to request permissions to reproduce articles or            DISCLAIMER
  information from this journal, please visit https://academic.oup.com/jour-        Statements of fact and opinion in the articles in The Journal of Clinical
  nals/pages/access_purchase/rights_and_permissions. For questions not              Endocrinology & Metabolism are those of the respective authors and
  answered in the instructions, contact journals.permissions@oup.com.               contributors and not of The Journal of Clinical Endocrinology &
  All rights reserved; no part of this publication may be reproduced,               Metabolism, the editors, the editorial board, the Endocrine Society, or
  stored in a retrieval system, or transmitted in any form or by any                Oxford University Press, none of whom make any representation, express or
  means, electronic, mechanical, photocopying, recording, or other-                 implied, in respect of the accuracy of the material in this journal and none of
  wise without prior written permission of the publisher or a license               whom can accept any legal responsibility or liability for any errors or omis-
  permitting restricted copying issued in the UK by the Copyright                   sions that may be made. The reader should make their own evaluation as to
  Licensing Agency Ltd, 90 Tottenham Court Road, London W1P 9HE, or                 the appropriateness or otherwise of any experimental technique described.
  in the USA by the Copyright Clearance Center, 222 Rosewood Drive,                 All manuscripts submitted for publication are subject to external peer
  Danvers, MA 01923.                                                                review as directed by the journal editors, other than (1) Endocrine Society
  TRANSLATIONS AND LICENSING                                                        Statements, which are reviewed by the Endocrine Society and selected
  For inquiries regarding translated reprints, local editions, or other full text   outside experts, and (2) meeting abstracts, which, when published have
  usage, please contact pharma.rights@oup.com.                                      been reviewed by the Endocrine Society’s Annual Meeting Steering
                                                                                    Committee. The Editors are not permitted to engage in discussions about
  COMMERCIAL REPRINTS AND SPONSORED SUPPLEMENTS                                     journal content for forthcoming issues with agencies involved in soliciting
  For commercial reprint or sponsored supplement inquiries, please visit            advertisements, or companies purchasing advertising space. The Endo-
  http://oupmediainfo.com/contact and complete the web form. Please note            crine Society does not evaluate advertised products or services nor assess
  the name of the journal you are inquiring about in the body of the form.          advertising claims. Neither the appearance of advertising in publications
                                                                                    of the Endocrine Society, nor reference to a product within the same,
  DISPLAY PRINT AND ONLINE ADVERTISING
                                                                                    constitutes a guarantee or endorsement of the quality or value of such
  Contact Joe Schuldner (Tel. +1-212-904-0377; jschuldner@pminy.com) and
                                                                                    product or of the claims made for it by its manufacturer. Advertisements
  John Alberto (Tel. +1-212-904-0364; jalberto@pminy.com) at Pharmaceuti-           are randomly placed, and there is no predetermined relationship be-
  cal Media, Inc. (PMI).                                                            tween the content and the advertisement. The Endocrine Society reserves
  DRUG DISCLAIMER                                                                   the right to decline or refuse advertisements.
  The mention of trade names, commercial products or organizations,                 INDEXING/ABSTRACTING
  and the inclusion of advertisements in the journal does not imply                 Please visit https://academic.oup.com/jcem/pages/About and see the Discov-
  endorsement by The Journal of Clinical Endocrinology & Metabo-                    ery Resources list for a full list of databases in which this journal is indexed.
  lism, the editors, the editorial board, the Endocrine Society, or Oxford
  University Press, or the organization to which the authors are affiliated.        AUTHOR GUIDELINES
  The editors and publishers have taken all reasonable precautions to               Full instructions for manuscript preparation and submission can be found
  verify drug names and doses, the results of experimental work, and                at https://academic.oup.com/jcem/pages/Author_Guidelines. For ques-
  clinical findings published in the journal. The ultimate responsibility for       tions, contact publications@endocrine.org.
  the use and dosage of drugs mentioned in the journal and in interpre-
  tation of published material lies with the medical practitioner, and the          Copyright © 2021 Endocrine Society

6A       https://academic.oup.com/jcem                                                                            J Clin Endocrinol Metab, March 2021, 106(3):6A
JCEM
 J Clin Endocrinol Metab, March 2021, 106(3):13A–20A                                                                                                   9A
                                                                                                                                              Contents  
                                                                                                                                THE JOURNAL
 March 2021 ● VOLUME 106 ● NUMBER 3                                                                                             OF CLINICAL
                                                                                                                                ENDOCRINOLOGY
 EDITORIAL BOARD                                                                                                                & METABOLISM

EDITOR-IN-CHIEF                                  Nicola Napoli, MD, PhD                               Serdar E. Bulun, MD
                                                 University Campus Bio-Medico                         Northwestern University
Paul M. Stewart, MD, FRCP, FMedSci               Rome, Italy                                          Chicago, Illinois, USA
University of Leeds
Leeds, United Kingdom                            Genevieve Neal-Perry, MD, PhD                        Sonia Caprio, MD
                                                 University of Washington School of Medicine          Yale University School of Medicine
                                                 Seattle, Washington, USA                             New Haven, Connecticut, USA
DEPUTY EDITORS
                                                 Elizabeth N. Pearce, MD                              Ada S. Cheung, MBBS (Hons),
Ursula B. Kaiser, MD
                                                 Boston University Medical Center                     FRACP, PhD
Harvard Medical School
                                                 Boston, Massachusetts, USA                           Austin Health and The University of Melbourne
Boston, Massachusetts, USA
                                                                                                      Melbourne, Australia

                                                                                                                                                            Downloaded from https://academic.oup.com/jcem/issue/106/3 by guest on 25 April 2021
                                                 Mark Sherlock, MB (Hons), BCh, BAO,
Raghavendra G. Mirmira, MD, PhD
                                                 MRCPI, MD, PhD                                       Ching-Lung Cheung, PhD
The University of Chicago
                                                 Royal College of Surgeons in Ireland and             The University of Hong Kong
Chicago, Illinois, USA                           Beaumont Hospital
                                                                                                      Hong Kong
                                                 Dublin, Ireland
ASSOCIATE EDITORS                                                                                     Mirjam Christ-Crain, MD, PhD
                                                 Hirotaka Watada, MD, PhD
                                                                                                      University of Basel
Takashi Akamizu, MD, PhD                         Juntendo University
                                                                                                      Basel, Switzerland
Wakayama Medical University                      Tokyo, Japan
Wakayama, Japan                                                                                       Adi Cohen, MD, MHSc
                                                 EDITORIAL BOARD                                      Columbia University
Felix Beuschlein, MD
                                                                                                      New York, New York, USA
University Hospital Zurich                       Carlos A. Aguilar-Salinas, MD, PhD
Zurich, Switzerland                              Instituto Nacional de Ciencias Médicas y Nutricion   Cosimo Durante, MD, PhD
                                                 Mexico City, Mexico                                  Sapienza Università di Roma
Ellen E. Blaak, PhD
                                                                                                      Rome, Italy
Maastricht University                            Erik K. Alexander, MD
Maastricht, The Netherlands                      Brigham & Women’s Hospital,                          Elif I. Ekinci, MBBS, FRACP, PhD
                                                 Harvard Medical School                               University of Melbourne
Stephanie T. Chung, MBBS (Hons), FAAP            Boston, Massachusetts, USA                           Melbourne, Australia
National Institute of Diabetes, Digestive and
Kidney Diseases                                  Trevor E. Angell, MD                                 Tobias Else, MD
National Institutes of Health                    University of Southern California Keck               University of Michigan
Bethesda, Maryland, USA                          School of Medicine
                                                                                                      Ann Arbor, Michigan, USA
                                                 Los Angeles, California, USA
Joshua N. Farr, PhD
Mayo Clinic College of Medicine
                                                                                                      Pamela U. Freda, MD
                                                 Caroline M. Apovian, MD
                                                                                                      Columbia University
Rochester, Minnesota, USA                        Boston University School of Medicine
                                                                                                      New York, NY, USA
                                                 Boston, Massachusetts, USA
Mônica Gadelha, MD, PhD
Universidade Federal do Rio de Janeiro
                                                                                                      Julia H. Goedecke, PhD
                                                 Natasha M. Appelman-Dijkstra, MD, PhD
Rio de Janeiro, Brazil                                                                                South African Medical Research Council
                                                 Leiden University Medical Center
                                                                                                      Cape Town, South Africa
                                                 Leiden, The Netherlands
David J. Handelsman, MB BS, PhD,
FRACP, FAHMS                                     Muthuswamy Balasubramanyam, PhD,                     Whitney S. Goldner, MD
ANZAC Research Institute, University of Sydney   FAMS, MNASc, FAPASc, FASCh                           University of Nebraska Medical Center
Sydney, Australia                                Madras Diabetes Research Foundation (MDRF)           Omaha, Nebraska, USA
                                                 Chennai, India
Jens Otto Lunde Jørgensen, MD, DMSci                                                                  Mathis Grossmann, MD, PhD, FRACP
Aarhus University Hospital                       Irina Bancos, MD                                     University of Melbourne
Aarhus, Denmark                                  Mayo Clinic                                          Heidelberg, Australia
                                                 Rochester, Minnesota, USA
Sangeeta R. Kashyap MD                                                                                Haixia Guan, MD, PhD
Cleveland Clinic Foundation                      Nienke Biermasz, MD, PhD                             Guangdong Provincial People's Hospital
Cleveland, Ohio, USA                             Leiden University Medical Center                     Guangzhou, China
                                                 Leiden, The Netherlands
Karen S.L. Lam, MD, FHKAM(Med),                                                                       S. Mitchell Harman, MD, PhD
FHKCP, FRCP(Edin, Lond), FRACP                   Michael S. Boyne, MD                                 University of Arizona College of Medicine and the
The University of Hong Kong                      The University of the West Indies                    Phoenix VA Health Care System
Hong Kong                                        Kingston, Jamaica                                    Phoenix, Arizona, USA

J Clin Endocrinol Metab, March 2021, 106(3):9A                                                                     https://academic.oup.com/jcem       9A
JCEM
                                     THE JOURNAL
                                                                                                                                                    March 2021
                                     OF CLINICAL
                                     ENDOCRINOLOGY                                  EDITORIAL BOARD                                                VOLUME 106
                                     & METABOLISM                                  continued from EB 4A                                              NUMBER 3

  Megan R. Haymart, MD                                V. Mohan, MD, PhD, DSc, FRCP, FACE                   Young Kee Shong, MD, PhD
  University of Michigan                              Dr. Mohan’s Diabetes Specialities Centre             Asan Medical Center
  Ann Arbor, Michigan, USA                            Chennai, India                                       Seoul, South Korea

  Angelica Lindén Hirschberg, MD, PhD                 Giovanna Muscogiuri, MD                              William F. Simonds, MD
  Karolinska Institutet and Karolinska University     University of Naples Federico II                     National Institutes of Health / NIDDK
  Hospital                                            Naples, Italy                                        Bethesda, Maryland, USA
  Stockholm, Sweden
                                                      Mitsuhide Naruse, MD, PhD                            Noel P. Somasundarum, MD
  Reiko Horikawa, MD, PhD                             Ijinkai Takeda General Hospital                      National Hospital of Sri Lanka
  National Center for Child Health and Development    NHO Kyoto Medical Center                             Colombo, Sri Lanka
  Tokyo, Japan                                        Kyoto, Japan
                                                                                                           Kathryn C.B. Tan, MD
  Gregory A. Kaltsas, MD, PhD, FRCP                   Karel Pacak, MD, PhD, DSc, FACE                      University of Hong Kong
  National and Kapodistrian University of Athens      National Institutes of Health / NICHD                Hong Kong
  Athens, Greece                                      Bethesda, Maryland, USA

                                                                                                                                                                 Downloaded from https://academic.oup.com/jcem/issue/106/3 by guest on 25 April 2021
                                                                                                           Manuel Tena-Sempere, MD, PhD
  Bente L. Langdahl, MD, PhD                          Stephanie Page, MD, PhD                              University of Cordoba
  Aarhus University Hospital                          University of Washington School of Medicine          Cordoba, Spain
  Aarhus, Denmark                                     Seattle, Washington, USA
                                                                                                           Elena Tsourdi, MD
  Kok Onn Lee, MBBS, MD, FRCP(Edin)                   Nelly Pitteloud, MD                                  Dresden University Medical Center
  National University of Singapore                    Centre Hospitalier Universitaire Vaudois             Dresden, Germany
  Singapore                                           Lausanne, Switzerland
                                                                                                           Adina F. Turcu, MD, MS
  Ana Luiza Maia, MD, PhD                             Catalina Poiana, MD, PhD, FACE                       University of Michigan
  Universidade Federal do Rio Grande do Sul           “Carol Davila” University of Medicine and Pharmacy   Ann Arbor, Michigan, USA
  Porto Alegre, Brazil                                Bucharest, Romania
                                                                                                           Anand Vaidya, MD, MMSc
  Monica Marazuela, MD, PhD                           Salman S. Razvi, FRCP, MD                            Brigham and Women’s Hospital
  Hospital de la Princesa, Universidad Autonoma       Newcastle University                                 Boston, Massachusetts, USA
  de Madrid                                           Newcastle upon Tyne, United Kingdom
  Madrid, Spain                                                                                            Bobbie-Jo Webb-Robertson, PhD
                                                      Sirimon Reutrakul, MD                                Pacific Northwest National Laboratory
  Erica E. Marsh, MD, MSCI, FACOG                     University of Illinois at Chicago                    Richland, Washington, USA
  University of Michigan                              Chicago, Illinois, USA
  Ann Arbor, Michigan, USA                                                                                 Jacques Young, MD, PhD
                                                      Michael Rosenbaum, MD                                University Paris Saclay, INSERM and AP-HP
  Christopher R. McCartney, MD                        Columbia University Irving Medical Center            Le Kremlin-Bicêtre, France
  University of Virginia School of Medicine           New York, New York, USA
  Charlottesville, Virginia, USA                                                                           Hongting Zheng, MD
                                                      Sebastian M. Schmid, MD                              The Second Affiliated Hospital of Army Medical
  Philippa Melamed, PhD                               Universität zu Lübeck                                University
  Technion - Israel Institute of Technology           Lübeck, Germany                                      Chongqing, China
  Haifa, Israel
                                                      Claudia E. Sedlinsky, MD                             Zhiguang Zhou, MD, PhD
  Zaher Merhi, MD, HCLD                               Instituto Cesar Milstein                             Second Xiangya Hospital of CSU
  Einstein & New York University School of Medicine   Buenos Aires, Argentina                              Changsha, Hunan, China
  New York, New York, USA
                                                      Nalini S. Shah, MD
  Veronica Mericq, MD                                 King Edward Memorial Hospital                        ENDOCRINE SOCIETY STAFF
  University of Chile                                 Mumbai, India
  Santiago, Chile                                                                                          Richard T. O’Grady, PhD
                                                      Susmeeta T. Sharma, MD, MHSc                         Publisher
  Geltrude Mingrone, MD, PhD                          Medstar Washington Hospital Center/Georgetown
  King’s College London                               University Hospital                                  Timothy M. Beardsley, DPhil
  London, United Kingdom                              Washington, DC, USA                                  Executive Editor

10A       https://academic.oup.com/jcem                                                                    J Clin Endocrinol Metab, March 2021, 106(3):10A
You can also read