IMPACT2021 - Responding to the Pandemic P.18 - Brown University
←
→
Page content transcription
If your browser does not render page correctly, please read the page content below
IMPACT Leading the Dialogue on Race P.14 The Big World of Tiny Nanocrystals P.40 RESEARCH AT BROWN 2021 Student Focus: Social Issues P.32 SPECIAL REPORT Responding to the Pandemic P.18
STARTING OFF CONTENTS THE COVID-19 PANDEMIC is one digital media: Dr. Ashish Jha, the new dean of the School of RESEARCH BRIEFS of the most devastating Public Health, is informing the nation on public health matters; public health challenges of economist Emily Oster is providing data-driven advice for 2 Saving “God’s Little Acre” modern times, but it has parents of school-age children; and Dr. Megan Ranney rallied her 4 Take the Sting Out of Mosquitos also given the world the ER coworkers as she called for national health care changes and 5 Alumni Impact: Suzanne Rivera most remarkable validation became a regular contributor on a major national news network. 5 The Dean of Urban Politics of the importance of Our research community successfully resumed most 6 Immunotherapy Enhanced government-supported operations over the summer, with rigorous new safety 6 Innovation to Impact in Medicine university research that we protocols and double shifts to accommodate reduced staffing 6 Alumni Impact: Alina Moran have seen in our lifetimes. densities. Brown faculty, staff, and students have been working 7 A New Approach to Genetic Testing Across the United States with dedication and innovation throughout the pandemic. As a 8 Everything in Moderation, Even Sports and the world, university laboratories closed for all but result, we’ve garnered many highly competitive awards. As one 9 Natural Language for Computers essential activities as COVID-19 cases increased and hospitals example, the National Science Foundation awarded Brown 9 Alumni Impact: Nicole Alexander-Scott and health care workers were overwhelmed. Yet, despite the $23.7 million for renewal of the Institute for Computational 10 The Unique Identities of uncertainty and losses, we have made extraordinary advances in research and in our understanding of the human experience. and Experimental Research in Mathematics (ICERM). In this issue of Impact, you will find stories about Brown 10 Immigrant Activists Research Honors 10 14 It has been an exceptional year for Brown research—one of research achievements in numerous fields, including a special 11 How Stimulants Really Work resilience and accomplishment. section devoted to COVID and a feature on the Center for the 11 Alumni Impact: Jonathan Karp In mid-March 2020, non-essential research ramped down at Study of Race and Ethnicity in America. Led by Tricia Rose, 12 Short Takes the same time most students left campus and the governor of CSREA is one of most highly regarded academic centers 13 Unpacking Lunar Ice Rhode Island issued a stay-at-home order. The emergency focused on scholarship on race and ethnicity—a topic brought reduction of laboratory research took only days to effect. into sharp relief as the nation grappled with anti-Black racism FOCUS Almost immediately, researchers galvanized to assist Rhode in 2020. This issue’s spotlight on undergraduate research Island’s health care system, with donations of PPE and other focuses on the work of our students in social issues. 36 Mathematics, Reimagined supplies to hospitals and frontline health care workers. It has been gratifying to see our University research 38 Books Born Digital Just as quickly, our researchers turned attention to urgent community respond to a challenging year so quickly, effectively, 40 The Big World of Tiny Nanocrystals questions related to the pandemic. The University’s COVID-19 and creatively. 41 School Discipline: The Race Gap Research Seed Fund, announced in April, accelerated innova- tive work of faculty and students on therapies, technology, and BROWN RESEARCH INDEX medical interventions. With this fund, 15 important projects launched, including a statewide Biobank providing patients’ 43 Books biological samples to researchers at Brown, as well as to Rhode 46 Selected Faculty Honors Island’s Lifespan and Care New England health systems. Jill Pipher Throughout this global crisis, many Brown researchers have been prominent voices in newspapers and in broadcast and Vice President for Research Elisha Benjamin Andrews Professor of Mathematics END NOTES 18 52 Ashish Jha and Megan Ranney: IMPACT Speaking Out 14 A Community in Conversation A Brown center has carved out a critical role in racial research and dialogue. BY SARAH C. BALDWIN ’87 RESEARCH AT BROWN 2021 18 Special Report: COVID-19 On the Cover: Amanda Jamieson, assistant Brown faculty have launched a wide range of research and Editor: Noel Rubinton Vice President for Research Office of Research Development Office of Foundation Relations professor of molecular microbiology and other projects to fight the pandemic. BY NOEL RUBINTON ’77 Designer: 2COMMUNIQUÉ Vp_research@brown.edu research_opps@brown.edu foundationrelations@brown.edu immunology at Brown, is working with 401-863-7408 Graphene Composites (GC), a nanomaterials Impact: Research at Brown is published annually by the Office of the Brown University Box 1937 Brown Technology Innovations tech-innovations@brown.edu For ongoing news about Brown research, follow engineering company, to develop and test a graphene and silver nanoparticle ink that has 32 Independent Inquiries Vice President for Research and the 350 Eddy Street us on Twitter @BrownUResearch. the potential to reduce the spread of COVID-19. Many undergraduates are succeeding in research related Office of University Communications Providence, R.I. 02912 Image by Graphene Composites to pressing social issues. BY MAURA SULLIVAN HILL PHOTOGRAPH BY NICK DENTAMARO/BROWN UNIVERSITY IMPACT 2021 1
RESEARCH BRIEFS A COMPENDIUM OF RECENT HIGHLIGHTS OF BROWN RESEARCH Saving “God’s Little Acre” Archaeology students are reviving the history of one of the oldest African-American cemeteries. FOR YEARS, STORIES of those buried in cans, many of whom were enslaved. Few God’s Little Acre in Newport, Rhode stories of people buried were preserved, Island, one of the oldest United States and the only known cemetery map dated cemeteries for Africans and African back to 1903 and was incomplete. Americans, had been slipping away Using three-dimensional images and despite a dedicated team of descendants aerial drone footage, graduate students and volunteers. Alex Marko, Dan Plekhov, and Miriam Stories like that of Charity “Dutchess” Rothenberg undertook an intense Quamino—who was brought to the investigation, recording the extensive United States from West Africa as a slave details on grave markers. They created in the 1700s and eventually became a an interactive map and database they pastry chef and caterer, later serving intend to make available to researchers George Washington for at least one and tourists. event—have been in danger of disap- “We know the bigger picture of the pearing as gravestones weather or recede slave trade and how inhumane it was,” into the Earth. Plekhov said. “You learn even more when Then three Brown archaeology you focus on individual people and graduate students were drawn into the individual experiences.” project by a volunteer at Newport’s Soon, Rothenberg said, “people can Historic Cemetery Advisory Commis- use a map on their phone or tablet to sion, and they became a key part of identify specific graves and interact with efforts to preserve and revive the history this site and its history more personally.” through a long-needed site map. Said Plekhov, “Making people aware Brown graduate The cemetery, founded in the late 17th of this lesser-known history, telling these students surveyed hundreds of grave century, is the final resting place of at stories . . . could drive us all toward a markers on the site. least 500 Africans and African Ameri- more inclusive future.” —jill kimball 2 IMPACT 2021 PHOTOGRAPH BY ALEX MARKO IMPACT 2021 3
RESEARCH BRIEFS ALUMNI Marion Orr specializes in urban, racial, and IMPACT ethnic politics. SUZANNE RIVERA ’91 became president of Experiments showed Macalester College in June graphene, a carbon 2020, the school’s first nanomaterial, could be a potent defense female and Latinx president. against mosquitos. She concentrated in American Civilization at Brown. “The best research The Dean of experience I had at Brown was a summer fellowship with Professor Greg Elliott in sociology, developing a new course on poverty in the United States. That research Urban Politics experience demystified the A veteran scholar brings the “hidden” work of academia and fostered in me the joy of into the open in his examinations of discovery. I’d never have been race and ethnicity. capable of serving in this role at Macalester College WHEN HE WAS AN UNDERGRADUATE student at Savannah State University, Take the Sting Out of Mosquitos without the excellent Marion Orr was inspired by a professor who “made political science come preparation and the courage to life.” Thirty-five years after he graduated, the American Political Science of convictions I got at Brown.” Association (APSA) made Orr, a Brown professor, the recipient of the 2019 Engineering researchers find a promising new tool to stop bites: graphene. Hanes Walton Award, which honors political scientists who have made significant contributions to the study of racial and ethnic politics—named after the man who compelled Orr to pursue his field of study. SOMETIMES, SCIENTIFIC breakthroughs are graphene can provide a two-fold defense cheesecloth. Cintia Castillho PhD ’20, Orr has authored or edited seven books, and his pioneering research made when researchers are looking for against mosquito bites. The ultra-thin the study’s lead author, said the graphene in urban politics and racial and ethnic politics has been widely recog- something else. material acts as a barrier that mosqui- material “was a chemical barrier that nized by experts in his field. His book The Color of School Reform: Race, Robert Hurt, professor in Brown’s toes are unable to bite through. prevents mosquitoes from sensing that Politics, and the Challenge of Urban Education was named the best book School of Engineering and leader of the Experiments also showed that graphene someone is there.” in the ASPA’s Urban Politics Section. He has chaired the governing university’s Superfund Research blocks chemical signals mosquitoes use Within days of its release, the board of the Urban Affairs Association, and at Brown has served as the Program, had been working with his to sense that a blood meal is near, study—funded by the National Institute director of what is now known as the Taubman Center for American team on fabrics that incorporate blunting their urge to bite. of Environmental Health Sciences, the Politics and Policy and as chair of the political science department. graphene as a barrier against toxic The study was based on research with Superfund Research Program, and the For the past several years, Orr has been working on an upcoming chemicals. “We started thinking about participants who placed their arms in a National Science Foundation—drew a biography of former U.S. Representative Charles Diggs, the first African what else the approach might be good mosquito-filled enclosure so that only a large amount of international media American in Congress from Michigan, a staunch civil rights activist, and for,” he recalled. small patch of their skin was available to and scientific attention. Hurt said founder and first chair of the Congressional Black Caucus. Orr has A novel idea emerged from the the mosquitoes. Researchers compared properly engineered graphene linings interviewed dozens of Diggs’s family members and former colleagues and brainstorming: mosquito bite protection. the number of bites participants received could be used to make mosquito-pro- has visited the six libraries of the presidents who served during his tenure. In a paper published in Proceedings on their bare skin, on skin covered in tective clothing, and “there’s a lot of While Diggs is often mentioned in histories, “no one has brought him of the National Academy of Sciences, cheesecloth, and on skin covered by a interest in non-chemical mosquito bite together in one place,” Orr said. “My book, I hope, will bring this hidden Hurt’s lab showed that multilayer graphene oxide film sheathed in protection.”—kevin stacey figure out into the open.” —li goldstein ’22 4 IMPACT 2021 PHOTOGRAPH BY ISTOCK PHOTO; HURT LAB/BROWN UNIVERSITY (INSET) PHOTOGRAPH BY DAVID J. TURNER (RIVERA); BROWN UNIVERSITY (ORR) IMPACT 2021 5
RESEARCH BRIEFS Immunotherapy Innovation “We have been focused on supporting and building capacity for translational A New Approach to Enhanced to Impact science,” said Dr. Jack A. Elias, senior vice president for health affairs and dean Genetic Testing in Medicine of medicine and biological sciences. “The Scientists are working to block BBII awards have been a great tool to help Two biomedical engineers are teaming up researchers move their discoveries along a key tumor-promoting protein. that pathway toward commercialization.” to make procedures less invasive. Five teams receive Part of the Brown and the Innovation IMMUNOTHERAPY—an important form of medical grants to make Economy initiative, BBII was started with GENETIC TESTS are the only way to The labs of Tripathi, an treatment that uses the body’s immune system to advances into $8 million in philanthropic gifts from definitively diagnose a range of engineering professor who focuses recognize, attack, and kill cancerous tumor Brown donors and is run by the medical conditions in developing on molecular diagnostics, and cells—has successes, but still fails with a commercial products University’s Division of Biology and fetuses, but getting samples is Shukla, an assistant professor of significant proportion of patients. benefiting patients. Medicine in collaboration with Brown invasive and risky. That has driven engineering who specializes in Now Brown scientists have found evidence Technology Innovations, part of the Brown researchers, led by biomedi- smart biomaterials, are collaborat- of a way to block a key tumor-promoting IN ITS PROGRAM to accelerate medical Office of the Vice President for Research. cal engineering professors ing on a new technique. They have protein, MDM2, that has been a significant discoveries becoming commercial “BBII is a cornerstone of Brown’s Anubhav Tripathi and Anita found a way to enrich trophoblasts roadblock to greater effectiveness in immunotherapy. technologies, Brown Biomedical efforts to inspire and support innovative Shukla, to advance a less invasive, from simple cervical swabs using a “Immunotherapy has been one of the biggest breakthroughs in Innovations to Impact (BBII) gave five research that will improve people’s lives, equally reliable alternative. low-cost and rapid methodology. biomedical science and medicine of the last two decades,” said Dr. Wafik awards to faculty research ranging from including treatments and cures for Currently, the most common The technique could enable doctors El-Deiry (pictured), a professor of pathology and laboratory medicine and analyzing infant cries for signs of opioid diseases,” said Jill Pipher, vice president way to diagnose genetic disorders to diagnose a wide range of genetic associate dean for oncologic sciences, and his lab’s finding could enhance withdrawal, to developing anti-malaria for research. during pregnancy is by retrieving disorders without using needles to immunotherapy. treatment, and more. Project proposals were reviewed by an trophoblasts—cells found in a harvest cells from the placenta. El-Deiry’s team found a drug that appears to be inhibiting the MDM2 Each research team was awarded advisory committee including venture mother’s placenta that carry the One of the project’s researchers, protein. “It’s tapping into a vulnerability within tumors to help immuno- $100,000 to help translate their scientific capitalists and pharmaceutical experts. complete fetal genome—through Christina Bailey-Hytholt PhD ’20 in therapy work better,” he said. Results of the study were published in the discoveries into commercial products amniocentesis or chorionic villus biomedical engineering, said, Nature journal Cell Death Discovery, and the research continues. benefiting patients. “The goal of the Project awardees are: sampling, both of which are “There is a large need for biomedical El-Deiry is inaugural director of the recently launched Cancer Center at program is to support biomedical QIAN CHEN, a professor of orthopedic invasive procedures that carry a engineering techniques toward Brown University, which in June became part of the highly selective technologies that need additional work research and medical science, to develop a gene risk of miscarriage. A less invasive advancing prenatal and women’s Association of American Cancer Institutes. The center builds on Brown’s to become products that have commer- therapy treatment for post-traumatic alternative involves blood tests that health.” A study about the new growing focus on translational science, aiming to have breakthroughs in cialization potential,” said Karen Bulock, osteoarthritis. look for fetal genetic material in a procedure was published by the basic research advanced to the point where they can make a meaningful the managing director of BBII, “includ- mother’s bloodstream. But those team in the journal Scientific medical difference for patients. “Establishing the Cancer Center at Brown ing navigating the gap between the time The team of KAREEN COULOMBE, an tests can’t be used for definitive Reports, and the work has been will support the programmatic integration of innovative cancer-relevant when federal research funding ends and assistant professor of engineering and medical diagnoses, and there’s a limited funded by the National Science research,” said El-Deiry. private investors are ready to invest.” science; BUM-RAK CHOI, an associate range of disorders that can Foundation and PerkinElmer Inc. professor of medicine (research); and ULRIKE be screened. —kevin stacey ALUMNI IMPACT MENDE, a professor of medicine, to design a test to make new therapeutic drugs that are safer for the heart. New technique could avoid using needles to harvest cells. JONATHAN KURTIS, chair of pathology and laboratory medicine, to develop antibody- ALINA MORAN ’93 was named president of Dignity Health–California Hospital Medical based therapeutics for malaria. Center in Los Angeles in February 2020. At Brown, she was an engineering concentrator. “Growing up in the Bronx, I did not have many opportunities to learn about how research can inform BARRY LESTER, director of the Brown Center action or prove a theory. As an engineering student, I was exposed to scientific observation— for the Study of Children at Risk, to search for identifying the problem, reviewing information, developing my hypothesis, and analyzing results. signs in newborn infants of opioid withdrawal. I used this in all aspects of life, in class, with my Hermanas sorority sisters, and with family. Decades later, research plays a prominent role in my profession.” ANITA SHUKLA, an assistant professor of engineering, to develop treatments to reduce dangerous fungal infections. —noel rubinton ’77 6 IMPACT 2021 PHOTOGRAPH BY ISTOCK PHOTO IMPACT 2021 7
RESEARCH BRIEFS Natural Language for Computers ALUMNI Communication is key to better interaction between humans IMPACT and computers. DR. NICOLE ALEXANDER-SCOTT MPH ’11 is director of the Rhode Island Department WHEN A COMPUTER program of Health. At Brown, she completed a encounters a word like four-year fellowship in adult and pediatric “apple,” explains Ellie infectious diseases at the Warren Alpert Pavlick (pictured), an Medical School and earned a master’s assistant professor of degree in public health. computer science at Brown, “COVID-19 is challenging us in unprecedented it will often comprehend ways. I am thankful that I can rely upon the tools it as a string of symbols— and values I developed as an infectious disease a-p-p-l-e—to be encoded into fellow and public health student at Brown to bytes. The driving question is: “What does the help me understand and respond to this computer actually need to know about the word pandemic. I draw upon these tools to ensure ‘apple’ to know what an apple is?” that every Rhode Islander has an equal Through her research in the area of natural opportunity to be healthy and safe.” language processing, Pavlick is working to answer that question by teaching computers to encounter language as a human might, in order to facilitate more versatile and meaningful interactions between humans and systems. Ever since her PhD, Pavlick has Risks of injuries for girls and boys in sports can be reduced. studied how to represent the nuances of language in computers, studying what a computer may need to know about a particular word in order to fully Everything in Moderation, Even Sports comprehend its meaning, on its own and in composi- tion with other words. At Brown, she conducts much of this research in collaboration with the Cognitive, Linguistic, and Intense, specialized training can hurt children. Psychological Sciences department. “We’re trying to figure out how humans represent language so that we “IT’S WONDERFUL for a child to love a Field said a common fear among Risk patterns differed for girls versus can reverse engineer it and implement it in computers,” sport and to want to engage in it,” said parents is that, if their children don’t play boys. For girls, no particular sport stood Pavlick said. Alison Field, professor of epidemiology more, they’ll fall behind in their sport. out as being extra risky to specialize in. Two recent grants, from the Defense Advanced and pediatrics. “But we must keep in “But it may actually be the opposite,” she However, specialization in general Research Projects Agency (DARPA) and the Intelli- mind the number of hours spent playing. said. “If children do too much, they may increased girls’ risk of injury by about gence Advanced Research Projects Activity (IARPA), They add up pretty quickly.” get injured and fall behind.” 30 percent. In contrast, specialization are enabling Pavlick to deepen her research. The first Field, who is affiliated with Brown’s Her findings, drawn from a multi-year in general did not significantly increase is tackling grounded language acquisition, an attempt School of Public Health and Warren study of 10,138 older children and teens boys’ risk of injury, but certain sports— to mimic in a computer how young children learn and Alpert Medical School, found in a study throughout the United States, suggest such as baseball and gymnastics— master language. With the IARPA grant of $6 published in the Orthopaedic Journal of that, although activity is good for health, increased risk. million—the largest received by the computer science Sports Medicine that injury dangers are there can be too much of a good thing. Field hopes the study’s conclusions department to date—Pavlick is teaming up with significantly higher for children who The youth engaging in the most hours of will help lead to less intense, less colleagues at Ohio State and the University of specialize in a sport from a young age intense activity per week, often involving specialized training, and include more Pennsylvania to design “cross-lingual search engines” and practice more frequently and specializing, are most likely to be cross-training and conditioning. that can return highly specific results and can intensely. seriously injured. —kerry benson function in any language. —li goldstein ’22 8 IMPACT 2021 PHOTOGRAPH BY ISTOCK PHOTO IMPACT 2021 9
RESEARCH BRIEFS Kevin Escudero’s goal: Research artificial intelligence, How Stimulants Really Work Honors “Texturing the narratives that machine learning, and human- I present about the activists.” computer interaction. Neuroscientists find that drugs like Ritalin operate Seven professors PETER MONTI (alcohol and addiction studies) for building by the brain doing a cost-benefit analysis. receive Brown’s understanding of the bio- THE COMMON ASSUMPTION has long been Brown postdoctoral researcher top awards. behavioral mechanisms that underlie addictive behavior as that Ritalin, Adderall, and other drugs Andrew Westbrook, the study’s lead well as its prevention and for the treatment of attention deficit author, added, “Our brains have been IN ITS ANNUAL program to treatment. hyperactivity disorder (ADHD) work by honed to orient us toward the tasks that honor exceptional scholars helping people focus. It turns out there’s will have the greatest payoff and the least across a wide variety of JOHN SEDIVY (molecular more to it. cost over time.” disciplines, Brown awarded biology, cell biology, and A study from researchers at Brown Westbrook and Frank hope their study Research Achievement biochemistry) for making marked the first time scientists examined will help future researchers and medical Awards to seven faculty advances in basic research on a precisely how stimulants such as Ritalin professionals better understand cognitive members. form of cellular aging and death alter cognitive function. They discovered mechanisms, allowing them to identify “It is a great pleasure to known as cell senescence. something new: The drugs actually work connections between levels of the recognize the singular by directing the brain to fix its attention neurotransmitter dopamine and disorders accomplishments of these on the benefits, rather than the costs, of such as anxiety, depression, and ADHD. The Unique Identities of The winners of 2020 seven researchers,” said Vice Early Career Research completing difficult tasks. “Our research is focused on disentan- President for Research Jill Achievement Awards are: Study author Michael Frank, a gling neural and cognitive functions to Immigrant Activists Pipher. “Beyond exceptional achievements, these awards are about something larger— SILVIA CHIANG (pediatrics) for clinical and epidemiological research on pediatric and professor of cognitive, linguistic, and psychological sciences and director of the Carney Institute’s new Center for understand people’s different thought processes and evaluate what’s best for their needs,” Frank said. A researcher digs deep to show the multifaceted Brown is truly making a adolescent tuberculosis. Computational Brain Science, said the The study, published in the journal difference in the world, study shows the drugs “increase your Science, was done in collaboration with world of youths. through both fundamental NICOLAS FAWZI (molecular cognitive motivation: Your perceived Radboud University in the Netherlands and translational research.” pharmacology, physiology, and benefits of performing a demanding task and funded by the National Institutes of WHEN KEVIN ESCUDERO began the research process for his book “Organizing While Provost Richard M. Locke biotechnology) for research are elevated, while the perceived costs are Health and the Netherlands Organiza- Undocumented: Immigrant Youth’s Political Activism under the Law,” he knew he said, “With its culture of centering on increasing under- reduced. This effect is separate from any tion for Scientific Research. faced a stiff challenge. With a renewed national focus on immigrant activism and the collaboration and excellence, standing of a class of RNA changes in actual ability.” —jill kimball federal government’s emphasis on creating “deserving” and “underserving” distinc- Brown is uniquely positioned processing assemblies whose ALUMNI IMPACT tions within the immigrant community, he needed to bring a fresh perspective to an to address critical societal dysfunction has implications area that had already been extensively researched and discussed. issues through rigorous for several neurodegenerative The difference, he decided, would come through his research approach and the research, teaching, and diseases. book’s overarching argument. Over the next five years, Escudero, an assistant service. Our faculty are professor of American Studies and ethnic studies at Brown, conducted a close central to these efforts. RAMELL ROSS (visual arts) for ethnographic study in San Francisco, Chicago, and New York, epicenters of immi- Research helps us understand his creative work as a writer, grant political activism. and mitigate great challenges, photographer, and filmmaker, JONATHAN KARP ’86 became CEO of Simon Escudero worked hard to honor his subjects’ unique identities in the book published and this year’s winners are including his film Hale County This & Schuster in May 2020. He concentrated in in March 2020, “texturing the narratives that I present about the activists.” He outstanding examples.” Morning, This Evening, nominated American Civilization at Brown. emphasized their multi-faceted identities as immigrants, people of color, and queer Nominations for the for a 2018 Academy Award for Best “When I wasn’t at the Brown Daily Herald learning to individuals, and the impact on the movement’s political strategies. awards were reviewed by Documentary Feature. ask ‘Who? What? When? Where? Why? How?’ UCLA Chicana/o studies professor Leisy Abrego, who spoke at a Brown sympo- panels of distinguished (essential questions for any manager), I was at the sium about Escudero’s book, praised his approach, saying, “Working honestly Brown faculty. ANITA SHUKLA (engineering), Rock, omnivorously browsing. Once, I discovered an through discussions on privilege, race, homophobia, transphobia, and inequalities for research focusing on obscure study of popular fiction. Years later, as an ultimately builds more trust and allows people to show up as their whole selves.” The winners of 2020 designing responsive and editor evaluating new works, I would think of that Also in 2020, Escudero received a CAREER award from the National Science Distinguished Research targeted biomaterials for musty book and its archetypes. I still carry my Rock Foundation, a highly selective early career honor. With the award’s five years of Achievement Awards are: applications in drug delivery ID in my wallet, in case I’m ever in the neighborhood.” funding, he will set up a research lab studying educational career pathways of immi- MICHAEL LITTMAN (computer and regenerative medicine. grant students, from college to graduate school to the workforce. —li goldstein ’22 science) for research focusing on —noel rubinton ’77 10 IMPACT 2021 PHOTOGRAPH BY BROWN UNIVERSITY PHOTOGRAPH BY GETTY IMAGES (PILLS) IMPACT 2021 11
RESEARCH BRIEFS SHORT TAKES A long-lost city from ancient Maya When organizations take a stand against actions to combat climate change, they get more news coverage civilization, Sak Tz’i’, was uncovered than their pro–climate action peers, according to a in a Mexican backyard by a research study from Assistant Professor of Environment and Society and Sociology Rachel Wetts. team including Associate Professor of Anthropology Andrew Scherer. New Rhode Island high school hockey safety Painter Jackson Pollock’s “drip” technique was geared guidelines were based on the concussion to avoid a classic fluid mechanical instability, whether he research led by Dr. Peter Kriz, clinical was aware of it or not, according to a study by Professor of Engineering Roberto Zenit. associate professor of orthopaedics and pediatrics at Warren Alpert Medical School. Research from Dr. Rebekah Gardner, associate professor of medicine, and Proving Einstein Right, a book by The Moon’s Shackleton Crater appears to be home to deposits of water ice. colleagues at UC San Francisco, showed Professor of Physics S. James that the narrative evaluations of medical Gates Jr. about the theory of students used for clerkships contained relativity, won the Brown Univer- Unpacking Lunar Ice significant gender and minority bias. sity Book Award and was given A surprising discovery on the Moon’s south pole could assist future astronauts. to high-achieving high school juniors around the country. FUTURE EXPLORERS ON the Moon will need more information sources and distribution of water in the inner solar system,” about resources available for fuel and other purposes, and new Deutsch said. “We need to understand the distributions of these research from planetary scientists at Brown could provide deposits to figure out how best to access them.” After receiving important clues. her PhD, Deutsch became a postdoctoral fellow at the NASA Victoria Almansa-Villatoro, a PhD student in The research’s discoveries about the age and sources of Ames Research Center to help further study the ice deposits. water ice on the Moon are expected to help both basic science The study, published in the journal Icarus, continues Brown’s Egyptology, worked with learning designers and exploration planning. The majority of the reported ice was long ties to NASA and planetary research. Deutsch worked with found within large craters dating back about 3.1 billion years or Brown professor James Head PhD ’69 and Gregory Neumann at Brown to create an interactive online longer, but the researchers also found evidence of ice in smaller PhD ’93 from NASA’s Goddard Space Flight Center. craters that appear to be relatively recent. Head said, “When we think about sending humans back to course about the pyramids, kings, and “That was a surprise,” said Ariel Deutsch PhD ’20, the the Moon for long-term exploration, we need to know what study’s lead author. “There hadn’t really been any observations resources are there that we can count on, and we currently societies of the third millennium B.C., of ice in younger cold traps before.” don’t know. Studies like this one help us make predictions “The ages of these deposits can potentially tell us something about where we need to go to answer those questions.” based on her fieldwork in Egypt. about the origin of the ice, which helps us understand the —kevin stacey 12 IMPACT 2021 PHOTOGRAPH COURTESY VICTORIA ALMANSA-VILLATORO PHOTOGRAPH BY NASA/GSFC/ARIZONA STATE UNIVERSITY IMPACT 2021 13
Brown’s Center for the Study of Race and Ethnicity in America has carved out a crucial role in dialogue and research. A Community in Conversation BY SARAH C. BALDWIN ’87 | PHOTOGRAPH BY ALEX GAGNE LAST SUMMER, DEMONSTRATIONS against police brutality, racism, and white supremacy rocked cities and towns from coast to coast. For many white Americans, the mobilization represented an awakening. For people of color—not to mention scholars of this country’s history—the moment felt all too familiar. But this time one thing was different: for many people, denying that racism is a foundational feature of the United States had become all but impossible. As Brown moved to advance understanding of this profoundly teachable moment, the Center for the Study of Race and Ethnicity in America (CSREA) became the heart of campus efforts. Based on its history, it was natural that, starting in September 2020, the center would host, along with other programs, “‘Race &’ in America,” a year-long series of panel discussions with distinguished researchers from around the university. Established in 1986, the CSREA was one of the earliest academic centers in the country focused on scholarship on race and ethnicity; at Brown, it is a site for research and dialogue about a topic that has arguably never been more urgent. Its move in 2016 to its current location in Lippitt House, in the heart of campus, mirrors the growing centrality of race and Tricia Rose, CSREA’s ethnicity in American academic and popular discourse. director: “Race is at the heart of whatever happens in our14country.” IMPACT 2021 ART CREDIT IMPACT 2021 15
In January 2020, the CSREA, along with centers at Yale University, the University of Chicago, and Stanford University, Tricia Rose led a conversation received a $4 million grant from the Mellon Foundation to with Trevor Noah, host of “The Daily Show,” at Brown in 2017. expand the study of race in the humanities across all four campuses. In addition to creating a faculty fellows program that will bring humanities scholars to the center for race-based research, the grant will make possible new multi-campus in 2019 that helped her refine an edited volume she’d been courses, free public events, exhibits, and conferences. One of working on with colleagues around the world. The event brought the signatures of Brown’s contribution is a humanities lab, a scholars from Jamaica, Brazil, and Ghana to the center—as well seminar-like space in which faculty and students can collabo- Providence, like elsewhere as others who joined via technology—for two days of workshops. rate in innovative, boundary-pushing ways and engage in what in the United States, was Rose calls “disciplined freestyling.” She says the lab will be a the site of many racial justice protests in 2020. CENTRIPETAL FORCE highly creative space in which to ask, “What if?” Reflecting her own multidisciplinary approach, Rose says the center invites people from within and beyond the humanities IT’S NEVER OVER and social sciences to contribute to the conversation. “If we were The CSREA records the vast majority of the events it convenes, “Race is at the heart of whatever happens in our country,” tion—through lectures, discussions, and workshops—of the just a center that’s a subset of a given discipline, we wouldn’t need and the nearly 200 videos in its ever-growing library can be says Tricia Rose AM ’87, PhD ’93, professor of Africana Studies range of normalized and interconnected policies, practices, and to be able to talk across lots of spaces. We’d have a specialized accessed for research purposes by anyone at any time because and, since 2013, director of the CSREA. “If we do not develop a attitudes that drive racial inequality in this country. language, and we would go deep instead of wide. But I think it’s race-related issues tend to be cyclical, receding and recurring more sophisticated understanding of how race works in When Rose accepted the CSREA directorship, she envi- much more important to create an interdisciplinary hub for across time. American society, we will not be able to produce a just, sioned the center as an “ideas hub” that would spawn new ways research and learning. Sociologists have to be able to talk to “The conversation evolves,” Rose says, “but it also continues multiracial democracy.” of thinking and talking about race, and a widely valued campus people in public health, who have to be able to talk to historians, to revolve around a set of issues. You can’t [look at the protests] What distinguishes racism in America, she says, is the asset: productive for faculty, important for students, engaging who have to be able to talk to people who work in biomed and of summer 2020 and suddenly say, What’s all this racial talk? enduring myth that it’s going away. In the post-civil rights era, for the public. genetics,” she says. “A center should bring people together.” What’s going on? You have to know there’s a long-term the fallacy of colorblindness—the idea that if, we refuse to “I have always been invested in making complicated ideas The center also supports fellowship programs to further the conversation about these issues. It’s important to be able to see acknowledge race and racial inequality, discrimination will that matter in the world interesting, relevant, and engaging. work of graduate students and faculty, and, with the Watson the conversation unfolding.” vanish—became entrenched across the political spectrum. The That to me is the point of being a teacher and a researcher,” Institute for International and Public Affairs, co-sponsors a Case in point: the “‘Race &’ in America” series draws on center is using scholarship and discussion to close the gap Rose says. It’s also the spirit that animates the CSREA. postdoctoral research associate in race and ethnicity. Ronald Brown scholars to probe the effects of race and anti-Black between the notion that racial and ethnic inequalities are a Through programming and rigorous research, she set about Aubert, current visiting professor of the practice, appreciates racism from a variety of perspectives, such as public health, thing of the past and the glaring truth that they are not. “building a community in conversation about race.” The the CSREA’s “unparalleled exposure to senior thought media depictions, and incarceration rates. In her virtual “Racism has been at the root of our darkest periods, and conversation would be both informed by scholars and accessi- leadership as well as the exciting intellectual energy of conversation series “Underlying Conditions,” also launched in despite the efforts of many across generations—including civil ble to all. The center has since convened many prominent emerging scholars across multiple disciplines.” Former postdoc 2020, Rose engages experts to explore the disproportionate rights activists, students and scholars—we know that racism is intellectuals, activists, and artists. One of the first public Mariaelena Huambachano credits the support she received impacts of the COVID-19 pandemic on communities of color pervasive today, and remains an obstacle to achieving true programs Rose organized, in 2014, took place shortly after a from the CSREA with encouraging her to continue her through a variety of lenses, including health disparities and the peace and justice for all,” says Provost Richard Locke. “At jury declared George Zimmerman not guilty of the murder of research and her work with the United Nations as an advocate effects on black businesses. Brown, we are committed to revealing and addressing legacies unarmed Black teenager Trayvon Martin: a teach-in featuring of indigenous people’s rights. Participating in a round table To maintain connections—and conversations—during the of structural racism and discrimination in our society, and we experts on the targeting of young people of color. discussion as part of “How Structural Racism Works,” says pandemic, the center created the e-newsletter “The Art of the are fortunate to have significant scholarly resources to draw That same year, as its public programming found its former Presidential Diversity Postdoctoral Fellow Yalidy Matter,” and started another that features a video pulled from upon in our work. Chief among these is CSREA, which brings audience on campus and beyond, the center began designing Matos, helped her expand her thinking about how structural its archive. And in June 2020 Rose partnered with another together thought leaders to investigate history and reflect and programs to support scholars in myriad ways—eventually racism interfaces with immigration, her area of study. public intellectual, Harvard scholar Cornel West, to create “The shape contemporary thought, policy, and practice.” offering manuscript workshops, writing retreats, course Notable among the CSREA’s extensive menu of research-fo- Tight Rope,” a virtual conversation/podcast on subjects innovation grants, and CSREA Faculty Grants. Intended to cused initiatives, which includes first-book events and informal ranging from pop culture to peace and justice. TIMELY, RELEVANT, AND SUPPORTIVE cultivate an intellectual community drawn from across Brown, workshops on current projects, are programs that support and Rose, who signs emails and letters “joy + justice,” admits to Rose, whom Ms. magazine called a “legendary Black feminist Faculty Grants provide funding and staffing for campus events showcase writers, artists, and performers. Past art exhibits have becoming weary at times in the battle for justice and its scholar,” has spent her career studying Black history, culture, and research groups that faculty members themselves devise explored microaggressions, appropriation of indigenous backlash. These, she says, are “bigger than the human spirit, if and sexuality in the post-civil rights era. She is perhaps best according to their academic interests. Over the years, these culture in modern media, and resilience, among other topics. you let them be.” But she’s also heartened by the speed with known for her pioneering 1994 book, Black Noise: Rap Music have included performances, films, seminars, and lectures on “Artists have always been the most powerful of voices for which things that were impossible to change five years ago and Black Culture, which helped establish hip-hop as a topic of topics as timely and diverse as school segregation, Latina helping us see things around us in ways that are often invisible seem to be changing today. scholarly focus. In 2015, she was tapped to direct the new “How feminism, indigenous language revival, the whiteness of food to those of us who don’t have that gift,” Rose says. “They have Of joy and justice, she says, “You can’t have one without the Structural Racism Works” series, another collaboration between movements, and refugees and immigration. the capacity to get at the heart of something in a way that other. We need a joyful approach to create justice. And joy can’t the Office of the Provost and the CSREA. Based on her ongoing Such a grant enabled Elena Shih, assistant professor of engages your spirit and soul as well as your intellect. They help happen in its full sense until we’re really invested in trying to research project, the initiative offers a campus-wide examina- American Studies, to hold a manuscript development workshop us connect in ways that words don’t.” produce a just world. Right?” 16 IMPACT 2021 PHOTOGRAPH BY DAVID DELPOIO PHOTOGRAPH BY NICK DENTAMARO/BROWN UNIVERSITY IMPACT 2021 17
SPECIAL REPORT: COVID-19 “Our faculty and their research are Bring in defined by extraordinary resilience, creativity, and generosity. I always knew these were characteristics of Brown, but to witness their impact in the context of this pandemic is amazing.” —Vice President for Research Jill Pipher the Sc ientists Dozens of Brown faculty launched COVID-19 research in the weeks and months after the pandemic started, attracting internal and external funding for projects stretching from biology and medicine to public health, engineering, computer science, economics, and more. While the recently started research is in its early stages, Brown’s COVID projects have already generated hundreds of published papers in respected journals, multiplied initial funding through additional sources, and grown through new collaborations within Brown and externally. 18 IMPACT 2021 ILLUSTRATION BY ISTOCK PHOTO IMPACT 2021 19
SPECIAL REPORT: COVID-19 For four researchers, COVID-19 provided immediate new possibilities. BEFORE COVID, VINCENT MOR was engaged Vincent Mor: “This is the in a broad range of research, including epitome of what applied research is all about.” co-leading the largest federal grant in University history, a $53.4 million award from the National Institute on Aging to help people with Alzheimer’s and their caregivers. At the end of January 2020, Mor, professor of health services, policy, and practice at Brown’s School of Public Health, chaired an Alzheimer’s meeting in Washington, D.C., with about 80 col- leagues from around the country, and COVID wasn’t a topic of any conversation. That quickly changed. A COMMUNITY RESPONDS “Right now there are already hundreds of millions of people in Brown faculty have become prominent voices during China whose lives have been completely turned upside down by BY NOEL RUBINTON ’77 the pandemic. Here are selected highlights of their the response to the virus.” —Katherine Mason, assistant professor of anthropology, PHOTOGRAPHS BY ALEX GAGNE expert commentary. The Scientific Inquirer, February 18 20 IMPACT 2021 ART CREDIT IMPACT 2021 21
SPECIAL REPORT: COVID-19 Little information about the effects of the virus week, on initiatives and to disseminate the results Harris describes the early weeks as a “sprinted on people in nursing homes had been released by of their research. marathon,” with work often going through the China, but it was clear that it was devastating Mor said an important goal of his research is to night, seven days a week. He and others got the residents of long-term facilities in Italy. “We knew build a counter-narrative, setting the record straight model ventilator operational for the first time at 4 that all hell was breaking loose in Italy and it was and informing future action. Many people have a.m. one night in late March. just a matter of time before it hit the United States,” accused nursing home companies, especially The Brown-designed ventilator went far in the Mor said. His team knew the window for action for-profit ones, for not taking enough care to mitigate challenge competition, getting to the top 65 of the would be brief: “I knew that nursing homes were the havoc of COVID. But Mor believes a more more than 1,000 entries worldwide, and the team going to feel the brunt of this.” accurate picture is that most nursing homes “are decided to refocus for the longer term. It combined By mid-March, Mor was talking to his program doing their very best” with little financial or scientific its work with two bio-engineering labs, one at officer at the National Institutes of Health (NIH) to support, facing waves of community transmission of Stanford University and one at the University of see what research would be most helpful. “He the virus that are not under their control. He said Utah. The expanded team then gained core impressed on us the importance of having data in solutions need to be on a broader scale: “Our data is international partners in India, Nepal, and Kenya. real time as quickly as possible,” Mor said. He pretty compelling, and outbreaks are not due to the The team’s communication network expanded from turned to Genesis HealthCare, a company he’d nursing homes’ behavior as much as they are one Slack channel to 20 different channels, on top worked with before and one of the largest nursing attributable to prevalence in the community.” of frequent Zoom calls. The research has had home providers in the country, with nearly 400 unexpected offshoots too. “This crisis has homes in 26 states. unearthed a lot of inequities in the medical device Quickly, Genesis agreed to give Mor’s team huge market globally,” Harris said, and the project data files on a daily basis in return for Brown leaders hope to spin off a foundation to help reduce Daniel Harris: researchers’ help in unraveling the many mysteries JUST BEFORE THE PANDEMIC, Daniel Harris, an assistant “I didn’t want to sit these inequities. of COVID, including its transmission and possible professor of engineering, was running a busy fluid on the sidelines.” As summer turned to fall, Harris’s research treatment at nursing homes. “We threw lots of mechanics lab in the new Engineering Research work shifted backed toward fluid dynamics projects resources at designing a system to receive nightly Center, including many graduate and undergradu- after his lab reopening plans were approved. Yet he downloads of data,” Mor said. It rapidly grew into a ate students. Suddenly all the work stopped in expects that his research trajectory will be forever large research initiative that is generating new ideas mid-March when Brown ramped down all but changed by the COVID experience: “I see a huge and knowledge about the effects of COVID in essential research. “It was a sad moment to leave a few weeks, even though they initially lacked a opportunity to use some of these skills for a very nursing homes. “This is the epitome of what applied vibrant lab and community,” he said. physical lab headquarters. But the group’s work different cause.” What has he learned about Brown research is all about,” he said. But the inactivity didn’t last more than a few quickly required a place for assembly and testing of from the experience? “How inter-disciplinary the Mor’s Alzheimer’s Collaboratory group found days. An engineering colleague, Roberto Zenit, equipment. Harris’s lab was allowed to reopen as a program is at Brown, with very few barriers . . . , additional ways to address COVID, receiving seven contacted Harris about the “Code Life Ventilator site for essential research, and he and some students and the passion and the capability of our under- supplemental awards from the NIH totaling over Challenge,” a global innovation effort to inspire started working in a deserted engineering building. graduate students.” $10 million. New project aims include advance teams to rapidly design a more efficient and easier to “It was an eerie feeling,” Harris said. care planning in assisted living facilities, strength- produce ventilator, a critical piece of life-saving At the same time, Harris took on another job, ening infection control, enhancing testing for equipment for many COVID patients. Harris joined unusual for a faculty researcher: delivery person. It historically underserved populations in nursing right away. “I didn’t want to sit on the sidelines,” he was temporarily impossible to deliver needed homes, messaging strategies to increase COVID said, even though he had never worked on medical equipment to the lab, and many on the team WHEN AMANDA JAMIESON went to Galveston, Texas, at vaccination uptake among nursing home residents devices before. couldn’t go into the restricted lab space anyway, the end of February for an international conference and staff, and monitoring incidence of adverse A rapid round of emails and phone and Zoom forcing them to build at home. The workaround on the Biology of Acute Respiratory Infection, she reactions to COVID vaccinations in nursing homes calls generated a Brown team, including faculty, was that Harris had packages delivered to his heard a lot about the dangers of COVID and its and the general population of older persons. His students, clinicians, and industry consultants. The house, and then he drove them to dorms and exponentially increasing spread. Back at Brown, she group has worked “flat out,” often seven days a team designed the Brun02 ventilator prototype in a apartments so teammates could use them. heard people talking about having a few more weeks “W hen it pops [in prisons], and it’s about to, it’s going to be “My experiences in Liberia [during Ebola] taught me that courage is “This pandemic is a wake-up call from the future. It tells us that we “The crisis has made clear that the United States has welcomed the really ugly.” not the absence of fear—it is doing what you know you must even need to re-imagine what we mean by the term ‘security threat.’” benefits of planetary interconnection but avoided the responsibili- —Josiah Rich, professor of medicine and epidemiology, when you are terrified.” —Stephen Kinzer, senior fellow at Watson Institute, ties that would help us weather the disasters that spread across Huffington Post, March 10 —Adam Levine, associate professor of emergency medicine, Boston Globe, March 18 the same global networks.” STAT, March 21 —Samuel Zipp, associate professor of American studies and urban studies, Washington Post, March 27 22 IMPACT 2021 IMPACT 2021 23
SPECIAL REPORT: COVID-19 Amanda before any possible shutdown. Jamieson, an assistant THE APPLIED MICROECONOMICS work of economics Jamieson: professor of molecular microbiology and immunol- professor John Friedman involves analyzing huge “Being an immunologist, ogy, was ready to start ramping down right away. amounts of data. “When the pandemic hit, we lost there had to be While shutting down many projects was painful access to some data sets,” Friedman said, and something we and caused significant research losses, Jamieson was progress on his work was greatly slowed. But before could do.” already looking forward: “Being an immunologist, long, he said, “We were trying to think about what there had to be something we could do.” She talked we could do to be helpful.” with members of her lab team and others, and, after Friedman does much of his research through the university announced its COVID-19 Research Opportunity Insights, a nonprofit that he is a Seed Fund in April, Jamieson applied for and codirector of and which is dedicated to using “big became the only researcher to be funded by two data” to turn its findings into policy change. He Seed awards. brainstormed with his fellow directors, Raj Chetty Working with Graphene Composites (GC), a and Nathaniel Hendren of Harvard, and soon a new nanomaterials technology company whose CEO is idea came up: to develop a real-time economic Brown alumnus Sandy Chen ’88, Jamieson is testing activity tracker. During the pandemic, they believed John Friedman: “Now this is a tool a graphene/silver nanoparticle ink formulation to be that businesses and others would especially want the that is out there for used in personal protective equipment as a way of most up-to-date statistics on income and spending policymakers.” reducing virus transmission rates. She said initial to help make policy decisions and adjustments. results have been promising. By May 7, the tracker was in operation and In her other Seed project, Jamieson teamed up publicly available, following successful negotiations with faculty from pathology and laboratory with many private companies to allow use of their medicine, as well as economics, to try to map the data on an anonymous basis. “It has been quite a bit At first, it was “an all-hands-on deck moment,” spread of COVID in the Rhode Island population of work on our part but a testament to the public- Friedman said. After a couple of months, he and and assess the role of asymptomatic cases. mindedness of these companies,” Friedman said. others have been able to get back to other research, Buoyed by her seed success, Jamieson applied for a A month later, Friedman and his colleagues but the tracker has continued to be a major project. highly competitive COVID Fast Grants opportunity, published a major research paper based on the He thinks the tracker is headed toward “chang- a program from Emergent Ventures in the Mercatus tracker, showing its ability to document—faster than ing things in a few different ways for economic Center at George Mason University. She won a had been done before—consumer spending, business research and policy.” The idea of a real-time tracker $300,000 award that she can use for anything related revenues, employment rates, and other key indica- had been talked about in the past, but never to COVID and which she plans to use for bioinfor- tors. By tapping into private companies’ data, accomplished. “What we capitalized on here was matics-related research to look at possible causes of important information and insights that previously that we are in a pandemic,” he said, “and it moti- blood coagulation defects in COVID patients. were not available for months through usual vated companies to do things they wouldn’t For several months, Jamieson’s whole team government sources were now possible within days ordinarily do. Now this is a tool that is out there for concentrated on COVID work, but was subsequently or a few weeks. Government websites became among policymakers.” able to resume its previous grant-funded research. the users of the data from Friedman and his team. Friedman added, “This is going to affect the way “In terms of techniques, it’s things we do a lot,” The response to the tracker was tremendously policy is made,” explaining that real-time data could Jamieson said of the COVID work. “But the subjects positive. Policymakers started using it, as did private allow for more targeted decisions, including by are completely new. It’s been really interesting companies and other academics. Media around the government. “We’re not going to give up on learning a new field. I have always felt that how world wrote about the tracker and its results and thinking about long-term upward mobility,” which people can survive respiratory disorders is impor- used the newly public data to do their own analysis. had been Opportunity Insights’ previous largest tant, and people are appreciating it more. It is more Friedman and colleagues started briefing U.S. research niche, “but we will keep going on this. This urgent now.” senators and House members using the tracker. is a space we are going to continue on.” “Counting on people’s memory [for COVID contact tracing] is less “Oil fields are not like wine bottles, where you can put in a cork “As a liberal, a 72-year-old, a bioethicist, and most of all as a human “If there’s one thing we learned in this crisis it’s that we can’t fall than perfect, especially when you have a really busy life.” [because of COVID] and return to it later. Shutting an oil field being, I am appalled that some states have set forth guidelines . . . behind the information curve. We need the most up-to-date —Anna Lysyanskaya, professor of computer science, down can damage it.” that call for discrimination against people in my age group in the information to make decisions.” WPRI-TV, April 17 —Jeff Colgan, associate professor of political science event of a shortage of ventilators or ICU beds.” —John Friedman, professor of economics, and international and public affairs, —Felicia Nimue Ackerman, professor of philosophy, MSNBC “Morning Joe,” May 7 The Guardian, May 8 New York Times, April 23 24 IMPACT 2021 IMPACT 2021 25
You can also read