GENESIS Biomed and GENESIS Ventures - Corporate Presentation March 2020

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GENESIS Biomed and GENESIS Ventures - Corporate Presentation March 2020
GENESIS Biomed and GENESIS Ventures
Corporate Presentation

                                                             March 2020

                                                             Please contact us at:
                                                             Baldiri Reixac 4, 08028 Barcelona
                                                             Velázquez 25, 2º A, 28001 Madrid
                                                             contact@genesis-biomed.com
                                                             +34 93 403 58 53
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Corporate presentation GENESIS Biomed

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Who are we?
                                                     GENESIS Biomed is a consultancy firm in the biomedical healthcare sector
                                                     specialized in providing consulting services to spin-off and start-up
                                                     companies, entrepreneurs and research centers.

                                                     Based in our expertise we help entrepreneurs and researchers to shape
                                                     their business plan and we support them in the private fundraising
                                                     process. We have raised >45 M€ in the last years.

                                                     We are Associate Partner at EIT Health and we are currently working in 7
                                                     EIT Health projects with TOP EU institutions.

                                                     Our expertise domains are biopharmaceutical, biotechnological, medical
                                                     devices, in vitro diagnostic, nutraceutical and cosmetic. With more than
                                                     20 years of expertise in the healthcare sector, we are born in May 2017
                                                     and we are located in the Barcelona Science Park.

                                                     In addition, the company owns GENESIS Ventures, a new fund sized in 2,0
                                                     M€ that invests in early stage research projects in the biomedical field,
                                                     with the aim to accelerate their development and reach key value
                                                     milestones to found the company and attract a first round of investment
                                                     from other venture funds.

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Our locations: Barcelona and Madrid

We are glad to announce that in
September 2019 we have open our
new offices located at Velázquez 25,
Madrid.

Located in the real center of Madrid,
our new offices will allow us to work
closely with the clients we have in
Madrid area.

In the coming weeks we will hire a
manager and two consultants for our
Madrid Office.
                                                  GENESIS Biomed HQ
We will keep our Barcelona staff in 10                                                    Madrid Office
members, and GENESIS CEO will be             Barcelona Science Park, Tower I
                                                                                   Calle de Velázquez 25, 2º A
working part time in both offices.                   Baldiri Reixac 4
                                                                                          28001 Madrid
                                                    08028 Barcelona

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Our portfolio of services

 1               Business Plan                          2             Private Fundraising                      3                 Interim CEO
  Preparation of business plans for spin-off or        Definition of the fundraising strategy. Selection           For those start-up companies with an
start-up companies, taking into account market,         of private investors among a wide personal             incomplete team. Serving as CEO and leading
 positioning, regulatory, development, IP, team        network and assistance in the fundraising and            the Project until identifying and hiring a full-
                 and financials.                                          negotiation.                                             time CEO.

 4              Strategic follow-up and supervision of current projects – For those companies developing a project after a first capital round,
                  continuous supervision and support in the strategic decision making of the company, serving as Board observer if needed.

 5             Market Analysis                          6    Regulatory and Development Plan                   7     Partners in EIT Health and H2020
Preparation of market and competitors analysis          Preparation of regulatory roadmaps including             Participation in European consortiums as
     using robust databases, knowledge                 regulatory strategy and development plans for             proactive partners, leading the business,
 management tools and fieldwork (interviews              biopharma, medtech, diagnostic, nutra and             regulatory and commercial work packages, in
              and focus groups).                                          cosmetic.                                  EIT Health, H2020, FTI and SME-2

 8           Business Development
                                                        9               Strategic Plan                        10            Training & Academy
      For companies and research centres.                  Preparation of strategic plans for research               For hospitals and research centres.
 In-licensing and out-licensing activities. Well               centres and companies, including                  Provide general knowledge in biomedical
established BD process built in the last 10 years        internal/external diagnostic, vision, strategic        entrepreneurship and technology transfer to
           + wide network of contacts.                            objectives and action plan.                           researchers and institutions

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Our value proposition in fundraising projects: from the Scientific case to the Investment case

               Investment case                    In the projects related to fundraising, we always start from the
                                                  Scientific Case, always excellent that comes from the Research
                                                                               Group.

                Business case                       We convert it into a Business Case, that is containing all the
                                                          aspects to be considered in a Business Plan.

                                                     Finally, creating a team between GENESIS Biomed and the
                                                   Research Group, we start a process that helps the investors to
                  Scientific                      create their Investment case that provides them support in the
                    case                                                    decision making.

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Participation in EU projects as proactive partners

                                         1      Preparation of Business Plan and Design of Business Model

                                         2       Market research and market analysis including fieldwork

                                         3              Implantation Plan and Market Access Plan

                                         4               Commercialization and Exploitation Plan

                                         5      Regulatory roadmap and Regulatory development activities

                                         6             Business Development for Licensing / M&A

   Currently working in 12 EU funded projects. We become very proactive partners in the preparation of the proposal
       and in the hearings. We are also a high proactive business partner during the development of the project.

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GENESIS Biomed becomes EIT Health Associate Partner

                                               Innovation Pillar                              Acceleration Pillar
                                                                                   GENESIS Biomed will apply to the appropriate
                                 GENESIS Biomed can contribute to take part as a
                                                                                   calls in which our expertise can contribute for
                                 consortium member in Innovation by Ideas or
                                                                                    the Pillar, such as bootcamps, Market Coach
                                 Innovation by Design projects.
                                                                                     Network, Investors network, Crowdfunding
                                                                                                platform, Catapult, etc.
  We have become Associate       The main tasks to be carried out will be:
           Partner                    • Business plans
        at EIT Health                 • Business coaching
      on May 14th 2018                • Commercialization                                        Campus Pillar
                                      • Business development
                                      • Preparation of WP0                         We can also contribute in Campus projects by
     We have also become
                                      • Etc                                        preparing Sustainability Plans or Bootcamps.
        Members of the
  Spanish Management Board
         at EIT Health

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EIT Health, the main biomedical European network with TOP companies and institutions

     Our presence in EIT
     Health as Associate
     partner allows us to
    collaborate with TOP
  international institutions

   In the last months we
       have started 8
   international projects

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Our current client portfolio (1/3)

 Spin-off and start-up                                                         Big & mid-size

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Our current client portfolio (2/3)

  Academia & Research

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Our current client portfolio (3/3)

  Healthcare                                                Investors          Institutional

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GENESIS team @ Barcelona Office: 11 very committed and passionate people

    Josep Lluís Falcó              Natalia de la Figuera                  Jordi Ortiz                           Carles Taulé                      Berta Borràs                        Mireia Samitier
 Managing partner & CEO           Managing partner & COO               Senior Consultant                         Consultant                        Consultant                           Consultant
   Chemist PhD, MBA                 Chemist PhD, PMP®                      Chemist                              Pharmacist                   Biotech. and Biochemist                     Biologist

                     Gisela Gallego                      Anna Miró                         Alberto Rodríguez                    Mariona Costa                         Teresa Bau
                       Consultant                        Consultant                        Consultant trainee                  Consultant trainee                  Comms Manager
                     Biotechnologist                 Biomedical Sciences                    Biotechnologist                     Biotechnologist                 Journalist & Digital MKT

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A highly committed team

                             Josep Lluís Falcó. Doctor in Chemistry (Institut Químic de Sarrià) and MBA (Universitat de Barcelona).

                             Josep Lluís has 21 years of experience in the biomedical sector. He has worked for big pharma companies (Sanofi), mid-size pharmas
                             (Ferrer Grupo), small biotechs (Hospital spin-off), Tech Transfer Offices (Fundació Bosch i Gimpera) and Consulting firms (Antares
                             Consulting and Asphalion). He has also been associate professor at IQS.

                             His experience is based in Healthcare Strategy, Technology Transfer, Fundraising of start-up companies, Business Development, Marketing,
                             Market Access, Reimbursement and Regulatory Affairs.

                             Josep Lluís has founded 4 companies. He currently serves as board member for 5 start-up companies and he is mentor of several
                             entrepreneurs. In addition in the last 5 years he has been involved in 11 private fundraising processes and he has contributed to raise 42
                             million euros for his clients.

                             The projects in which Josep Lluís has been involved are based in small chemical entities, biologicals, diverse medical devices, in vitro
                             diagnostics, nutraceuticals and cosmetics.

                             The therapeutic areas where he has recently worked are Oncology, Central Nervous System, Cardiovascular, Ophthalmology, Orthopedics,
                             Traumatology, HIV, Microbiome, Antibacterials and Immunomodulation.

                             He has global knowledge of drug/device development, having worked in Discovery, Preclinical and Clinical phases, Marketing and Post-
                             Marketing.
Josep Lluís Falcó
Managing partner and CEO     He takes part of programs such as Caixa Impulse and EIT Health programs, participating as reviewer, mentor and professor.
jlfalco@genesis-biomed.com   The entrepreneurial spirit runs through his veins. He has founded GENESIS Biomed to help other entrepreneurs and research centers in
                             their current projects.

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A highly committed team

                                  Natalia de la Figuera. PhD in Chemistry, Master in Project Management, PMP®

                                  Natalia has developed her professional experience both in academic (CSIC Madrid and Barcelona) and in the
                                  pharmaceutical industry: big pharma (Fresenius Kabi, Sanofi, Lilly, Merck-Serono), mid-size (Almirall, Palau Pharma)
                                  and start-ups (Ojer Pharma, ImmunNovative Developments, Enantia).

                                  She has worked in different positions in areas as project management, regulatory affairs, R & D and Quality among
                                  others.

                                  The main therapeutic areas on which she has been involved were oncology, central nervous system, anti-inflammatory,
                                  antibacterial, autoimmune diseases and cardiovascular.

                                  From 2015 she has been focused mainly in project management, broadening her knowledge on economic-
                                  administrative monitoring and controlling, changes request and dissemination results of projects.

                                  During her last job in the FSJD (Fundació Sant Joan de Déu) she was involved on public funding projects, some of them
                                  collaboratives, allowing her to acknowledge another health environment.
Natalia de la Figuera             She joins GENESIS Biomed in April 2019. She is a passionate of improving health and quality life for patients
Managing partner and COO
ndelafiguera@genesis-biomed.com

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A highly committed team

                             Jordi Ortiz. MSc in Chemistry, Biochemistry field (Universitat de Barcelona)

                             He completed his Master Thesis in Cation-induced aggregation and fusion of N-acyl-N-methylphosphatidyl-
                             ethanolamine liposomes and continued his research by studying the lipid-protein interaction.

                             In 1994, he joined the pharmaceutical industry and has occupied several positions, always in the R&D area (from
                             Discovery to Clinical phases). He has worked in Sanofi, Ferrer and Spherium Biomed. In this last company he has hold
                             the position of Senior Project Manager working in several projects from the discovery phase until the clinical research
                             phase.

                             He has an extended experience in several management positions in regulated analysis laboratories and as project
                             manager with both large and small molecules.

                             During the last years, he has been working in Autoinmune Diseases, Muscle recovery, ALS, Oncology Mucositis and
                             Acute Kidney Injury.

                             Jordi has also a deep expertise in European public fundraising and in Business Development activities, all of them
                             related to the projects in which he has participated.
Jordi Ortiz
Senior Consutant             He joins GENESIS Biomed in March 2019. He is a passionate of biomedical innovations of academic origin in order to
jortiz@genesis-biomed.com    accelerate their transition to the market.

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A highly committed team

                              Carles Taulé, BSc in Pharmacy (Universitat de Barcelona) and Master in Management of Biomedical Companies
                              (CESIF).

                              After several years as intern in Pharmacy Offices, in 2015 completes his Master Thesis in: “Role of Gram-positive
                              vesicles in the acquired resistance mechanisms of staphylococcal biofilms” in Department of Biomaterials,
                              Sahlgrenska Academy, University of Gothenburg (Sweden). In 2017 he has been involved in several technology
                              transfer projects at Fundació Bosch i Gimpera.
         Carles Taulé
                              He joins GENESIS Biomed in September 2017. With a high entrepreneurial spirit, Carles is focused in the creation,
          Consultant          valorization and fundraising of spin-off and start-up companies in the biomedical environment.
  ctaule@genesis-biomed.com

                              BSc in Biotechnology (Universitat Autònoma de Barcelona, 2012), BSc in Biochemistry (Technische Universität
                              Hamburg-Harburg, 2013) and Master in Pharmaceutical Industry and Biotechnology (Universitat Pompeu Fabra,
                              2015).

                              Berta has worked for 2 years at the Tech Transfer Office of IDIBELL (Institut d'investigació Biomèdica de Bellvitge).
                              Her fields of expertise are project management, fundraising and technology transfer. Previously, she worked as an
                              intern at some R&D laboratories (Esteve, Charité, Humboldt University of Berlin and IMIM).

         Berta Borràs         She joins GENESIS Biomed in May 2018. Science is her passion and she seeks to help entrepreneurs start their own
          Consultant          business.
 bborras@genesis-biomed.com

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A highly committed team

                               BSc in Biology (Universitat de Barcelona, 2013) and Master in Genetics and Genomics (Universitat de Barcelona,
                               2014).

                               In the lasts three years Mireia has worked as research assistant in various stem cell projects in the field of heart and
                               and kidney differentiation in IBEC (Institut de Bioenginyeria de Catalunya).

                               She joins GENESIS Biomed in June 2018. She loves science and looks forward to support the creation of new start-
                               ups in the biomedical field.
       Mireia Samitier
         Consultant
msamitier@genesis-biomed.com

                               BSc in Biotechnology (Universitat de Vic, 2011) and Master in e-Health (Universitat Oberta de Catalunya, 2015).

                               In the last two years Gisela has worked in the Tech Transfer and Innovation Office of Sant Pau Research Institute,
                               with expertise in IP management and business development. She has three years of previous experience in e-Health
                               Project Manager as well as QMS Responsible at an ICT SME for the health sector.

                               She joins GENESIS Biomed in September 2018. Passionate about e-health and biotechnology, she seeks to help
                               entrepreneurs to bring innovation to society.
         Gisela Gallego
          Consultant
 ggallego@genesis-biomed.com

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A highly committed team

                                BSc in Biomedical Sciences (Universitat de Lleida, 2018) and Master in Management of Biotech companies at
                                CESIF.

                                Anna has experience as a research assistant in some different areas (biophysics, neuroscience and pathological
                                anatomy) in laboratories belonging to University of Pécs (Hungary), Universitat de Barcelona and HUAV Lleida. She
                                developed her final dissertation in IDIBAPS (Barcelona) studying the role of nutrigenomics in the progression of type
                                2 diabetes. She has finished a Master in Management of Biotech companies (CESIF), acquiring all the necessary
                                knowledge to develop her skills in the sector.
         Anna Miró
         Consultant             Anna joins GENESIS Biomed in March 2019. She is willing to assist entrepreneurs in the establishment of their new
  amiro@genesis-biomed.com      innovative companies.

                                BSc in Biotechnology (Universitat de Barcelona, 2019) and MSc in Technology and Management of Biotech
                                companies (CESIF, 2020).

                                Alberto has experience as an undergraduate researcher in laboratories belonging to the University of Cologne
                                (Germany). He developed his Bachelor´s Thesis in CECAD (Cologne) studying ubiquitin and its effect on cellular
                                regulation and homeostasis under stress conditions, under the supervision of Dr. Mafalda Escobar-Henriques Dias.
                                Eager to acquire and develop his career in Biotech based companies' management he is attending to a Master´s
                                Degree in Technology and Management of such companies at CESIF. Alberto joins GENESIS Biomed in January 2020.
       Alberto Rodríguez        With his scientific background he looks forward to help in the development of spin-off and start-up companies,
       Consultant trainee       considering technology transfer as a tool of innovation.
arodriguez@genesis-biomed.com

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A highly committed team

                             BSc in Biotechnology(Universitat de Barcelona, 2019) and Master in Management of Biotech companies at CESIF.

                             Mariona studied Biotechnology and is currently attending a Master in Management of Biotech companies at CESIF in
                             order to assist the establishment and growth of small biotechnological companies. She performed her final degree
                             project in the Spin-off DBGen Ocular Genomics where she performed tasks related to the optimization of Inherited
                             Retinal Disorders’ genetic diagnose.

                             She joins GENESIS Biomed in January 2020. She is passionate of Life Sciences and looks forward to support spin-off
       Mariona Costa         and start-up creation.
      Consultant trainee
 mcosta@genesis-biomed.com

                             Degree in Journalism (Universitat Autònoma de Barcelona), postgraduate course in Medical Communications (Universitat Pompeu
                             Fabra), Translation Studies at Universitat Autònoma and University of Glasgow and Digital Marketing in ESADE.

                             Teresa has over 15 years experience as a reporter and communications specialist, mainly working for the healthcare sector, with a focus
                             on digital health. In the last years she has worked for organizations such as Novartis, HIMSS Europe, Patient Power, UOC eHealth
                             Center, UpToDate, Among Doctors, Mobile World Capital.

                             Teresa’s areas of expertise include digital communications, social media, communications strategy, content production, digital
                             marketing, media relations, PR, Patient Engagement. She has a large network of contacts in the health sector at a national and
        Teresa Bau           international level. She is a member of the Catalan Association of Scientific Communication and the Journalists College.
   Communications Manager
                             Teresa joins GENESIS Biomed in January 2020.
  tbau@genesis-biomed.com

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Our Scientific Advisory Board

                              Dr. Josep Tabernero                                                            Dr. Pere Ginés
                   Chairman of the Board – Expert in Oncology                                             Expert in Hepatology
                                                                                        Chairman of Liver Unit, Hospital Clinic Barcelona; Full Professor
                Head of the Department of Medical Oncology in Vall d’Hebrón
                                                                                            of Medicine, University of Barcelona; Director of Liver
                 University Hospital; Director of the Vall d’Hebrón Research
                                                                                            Transplantation; Head of Research Group, IDIBAPS and
                                    Institute in Oncology.
                                                                                                                  CIBEReHD.

                                 Dr. Rafael Cantón                                                      Dr. José Luís Molinuevo
                            Expert in Infectious Diseases                                                Expert in Neurology
                Head of the Clinical Microbiology Department at the University          Scientific director and Head of the Clinical, Biomarker and Risk
                   Hospital Ramón y Cajal; associated Professor of Clinical             Factors Research Group at the Barcelonabeta Research Centre
                     Microbiology at Complutense University of Madrid.                     (BBRC); associate professor in University Pompeu Fabra.

                           Dr. Francisco Fernández Avilés                                                   Dr. Rafael Simó
                                 Expert in Cardiology                                                   Expert in Endocrinology
                 Full Professor of Cardiovascular Medicine at the Complutense            Chair of the Division of Endocrinology and Nutrition at Vall
                University (UCM); Chairman of the Department of Cardiology in             d’Hebron University Hospital; Director of Diabetes and
                the University Hospital Gregorio Marañón of Madrid; Scientific          Metabolism Research Unit at Vall d’Hebron Research Institute
                  Director of the Spanish Network Centre for Cardiovascular                (VHIR); Professor of Medicine & Endocrinology at the
                                      Research (CIBERCV).                                           Autonomous University of Barcelona.

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The needs we understand for a fundraising process with a startup. Our Methodology

                                              For a fundraising process with a given startup, there are some important steps to accomplish prior starting the
                                              roadshow. For that purpose, an Interim CEO should lead the fundraising process, including:

                                              •   Business plan preparation and cash need dimension
                                              •   Fundraising strategy set up
                                              •   Selection of the most suitable VCs for the fundraising, taking care of:
                                                     •    Lifecycle of the current funds
                                                     •    Lifecycle of the invested projects
                                                     •    Portfolio of invested projects
                                              •   Preparation of the roadshow with investors
                                              •   Starting of the fundraising process:
                                                     •    Non-confidential approaches and contacts
                                                     •    First TCs and meetings
                                                     •    Signature of NDA
                                                     •    Starting of building the syndicate up
                                                     •    Negotiation of the Term Sheet
                                                     •    Creation of a Data Room and coordination of the Due Diligence
                                                     •    Negotiation of the Investment and Shareholders Agreement
                                              •   In the meanwhile, identification of the full-time CEO that will join the spin-off company

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Our Methodology. Which are the 10 success factors to learn and implement? (1/5)

                                          1. Market Analysis
                                              • Current unmet medical need
                                              • Epidemiology
                                              • Determination of market size
                                              • Description of market trends
                                              • Analysis of main players in the market (commercial products)
                                              • Description of the future competitors (development projects)

                                          2. Competitive positioning
                                               • Analysis of main features of current and future competitors
                                               • Price analysis
                                               • Business model analysis
                                               • Market share analysis
                                               • Voice of Customer and Cost-effectiveness analysis
                                               • Competitors matrix

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Our Methodology. Which are the 10 success factors to learn and implement? (2/5)

                                          3. Proof of Concept results
                                               • Complete list and description of studies done till date
                                               • Main results obtained and conclusion analysis
                                               • Studies to be conducted in the future
                                               • Current agreement with the Main Institution
                                               • Outsourced studies and external collaborations
                                               • R+D Gantt chart

                                          4. Intellectual Property
                                                • List of filed patents till date
                                                • Analysis of the current situation of each filed patent
                                                • List of potential future patents in the project
                                                • Freedom to operate analysis
                                                • License Agreement from the Institutions
                                                • IP strategy of the company

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Our Methodology. Which are the 10 success factors to learn and implement? (3/5)

                                          5. Regulatory Strategy
                                               • Regulatory framework for the current project
                                               • Analysis of the corresponding guidelines and directives
                                               • Current regulatory considerations
                                               • Future trends and regulatory changes
                                               • Regulatory strategy and validation
                                               • Regulatory roadmap

                                          6. Development plan
                                               • List of all needed studies for the development of the product
                                               • Gantt chart for the whole development process
                                               • Identification of main milestones
                                               • Measurement of timelines
                                               • Identification of potential outsourced partners
                                               • Prediction of associated costs

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Our Methodology. Which are the 10 success factors to learn and implement? (4/5)

                                          7. Internal team of de company
                                                • Existing team and initial roles
                                                • Presence of a full-time CEO
                                                • Complete job description for all needed roles in the future
                                                • Organigram analysis and Headcount evolution in the company
                                                • Analysis of salaries and ESOP for internal staff
                                                • Partners Agreement, Governance and Reserved matters

                                          8. External team
                                               • Profiles needed for the Scientific Advisory Board
                                               • Design of the Board of Directors
                                               • Identification of the Chairman
                                               • Identification of suitable outsourced roles and service providers
                                               • Analysis of costs and quotations
                                               • Design of ESOP for key external people

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Our Methodology. Which are the 10 success factors to learn and implement? (5/5)
                                          9. Financial Plan
                                                • Definition of the Business Model of the company
                                                • Quantification of the global cash need
                                                • General Risk Analysis and mitigation plan
                                                • Main financial milestones and Identification of Tranches
                                                • Fundraising strategy for Investors and Exit scenario analysis
                                                • Valuation of the company and Cap Table analysis
                                                • Preparation of the Financial Plan: CF, P&L and BS

                                          10. Strategy and Fundraising negotiation
                                               • Selection of the most suitable investors
                                               • Preparation of the slide deck of the company
                                               • Roadshow and first meetings round
                                               • Building the syndicate up
                                               • Analysis and negotiation of the Term sheet
                                               • Preparation of Data room for Due diligence
                                               • Negotiation of the Investment Agreement and Partners Agreement
                                               • Closing of the Round

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Last success cases in fundraising. Our Track record

            Signed deals             Sector         Round size   Year   Investors
            AptaTargets              Pharma         4,5 M€       2017   Caixa Capital Risc, Inveready
            Anaconda Biomed          Medtech        15 M€        2017   Ysios, Omega, Innogest, BSabadell
            Peptomyc                 Biotech        4,2 M€       2017   ALTA Life Sciences, Healthequity
            GlyCardial Diagnostics   IVD            3,1 M€       2017   Caixa Capital Risc, Healthequity
            MJN Neuroserveis         Medtech        750 k€       2018   Ship2B and Family Offices
            Cornea Project           IVD            300 k€       2018   Industrial partner
            Corify Care              Medtech        1 M€         2019   Family Office and EU Funds
            Oxolife                  Pharma         300 k€       2019   Family Office
            Cornea Project           IVD            300 k€       2019   Family Office
            LiverScreen Project      Medtech        8,5 M€       2019   EU Funds
            CreatSens                IVD            750 k€       2019   EU Funds
            ABLE Human Motion        Medtech        2,5 M€       2019   EU Funds

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Our success stories in fundraising

                                •   Medtech project: stratification of patients suffering from atrial fibrillation
                                •   1 M€ raised in January 2019
                                •   Investors: Family offices and EU funds

                                •   Pharma project: new aptamer for ischemic stroke
                                •   2,7 M€ raised in May 2017
                                •   Investors: Caixa Capital Risc and Inveready

                                •   Medtech project: new catheter for thrombectomy
                                •   15 M€ raised in May 2017
                                •   Investors: Ysios, Omega, Innogest, Banc Sabadell

                                •   Biotech project: recombinant protein for NSCLC and TNBC
                                •   4,2 M€ raised in July 2017
                                •   Investors: ALTA Life Sciences and Healthequity

                                •   IVD project: new biomarker for cardiovascular ischemia
                                •   2,4 M€ raised in October 2017
                                •   Investors: Caixa Capital Risc and Healthequity

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Current projects in fundraising process

                       Company sector          Product      Indication             Round size
                       Ophtalmology            IVD          Cornea disorders       3,6 M€
                       Cardiovascular          Medtech      Atrial fibrillation    15 M€
                       Nephrology              IVD          Renal failure          300 k€
                       Women’s health          Pharma       Fertility              8,1 M€
                       Gastrointestinal        Medtech      Chronic Constipation   5 M€
                       Ophtalmology            Pharma       Retinitis pigmentosa   500 k€

                                          GENESIS Biomed - Corporate Presentation               30
02
Presentation of our new fund GENESIS Ventures

                     GENESIS Biomed - Corporate Presentation   31
02 Presentation of GENESIS Ventures
  Context and need for a New Fund in Tech Transfer (1/2)

                                                                        Activities for GENESIS Biomed during this year
                           GAP                                Business plan                               Fundraising       General
                                                                                   Interim CEO
               Projects need to be valorised                   preparation                                  support        support…

Month -12…               Month -6                   Month 0                          Month 6                         Month 12

                                               GENESIS Biomed starts
                                                                               After the work done by           The startup is founded
                                                working with a client
                                                                                GENESIS, the project is         and the financial round
                                               coming from hospital,
                                                                               ready to start roadshow           is closed. The project
                                               university or research
                                                                                  with VC investors              development starts…
                                                       center

                                         GENESIS Biomed - Corporate Presentation                                                      32
02 Presentation of GENESIS Ventures
Context and need for a New Fund in Tech Transfer (2/2)

Questions related to this GAP:

1. All researchers lack of funds for the valorisation
   of their projects
2. Usually the researchers are not business
   oriented when deciding which studies to
   perform
3. With funds & advise, the GAP can be shortened
   and the project can be ready to start the
   fundraising process in advance

                                      GENESIS Biomed - Corporate Presentation   33
02 Presentation of GENESIS Ventures
Lifecycle and portfolio management for GENESIS Ventures

  GENESIS Ventures                                                            The spin-off is                                                             The series A is closed with
     invests in the                                                          founded and GV                                                              VC investors. GV remains as
   research project                                                        becomes shareholder                                                            shareholder until the exit

         Period of time in which the ticket will be devoted to the valorisation of the       Period of time in which GENESIS Biomed will support the spinoff (potential GENESIS’ client)
  research project (new experiments to generate new results to increase the project value)             in the fundraising process to finally close a series A with Venture Capital

                                                                  GENESIS Biomed - Corporate Presentation                                                                                  34
02 Presentation of GENESIS Ventures
Investment policy with a given identified project that will become spin-off in 1 year

Phase 1: Pre-foundation of the spin-off                 Phase 2: Foundation of the spin-off

           Our Total Fund: 2,0 M€                          After the investment period, the spinoff company should be founded. If the spinoff is
                                                           not founded and the project is licensed to a third party, the Investment Agreement
                                                           regulates the return to GENESIS Ventures (via upfront and/or royalties).
        Tickets*: 25.000 – 100.000 €
                                                           In the foundation, GENESIS Ventures acquires the corresponding shares committed
     Investment Agreement is signed                        in the Investment Agreement. Our policy is not to become a major shareholder.
        with Research Center and
             Research Group
                                                           After the foundation, GENESIS Biomed will help the new spinoff (becoming potential
                                                           GENESIS’ client) in the fundraising process in order to close a series A with Venture
   Max. time to found NewCo*: 1 year                       Capital investors.

     GENESIS Biomed will manage the
       projects and will inform the                        Exit scenario: the standard exit scenario for Venture Capital once the Company is
         Investments Committee                             acquired or the project is out-licensed to a third party.

* Orientative figures. These will be fixed in a case-by-case basis

                                                      GENESIS Biomed - Corporate Presentation                                                      35
02 Presentation of GENESIS Ventures
Our invested projects till date

                         ELEM                 ADmit Tx              Aptamer                Quality           MOWOOT
 NeuroHeal                                                                                 Pharma
   Spinoff UAB
                      Spinoff BSC-UPC         Spinoff IDIBELL        project                                     Start-up
                                                                    Spinoff IRYCIS         Medtech
                     Developing a new       Developing a new                            Spinoff Karolinska   Developing a new
Developing a new
                        software for           IVD for early      Developing a new                            solution for SCI
   therapy for
                      virtualization of        detection of       aptamer for Breast    Developing a new        and chronic
neuroregeneration
                       human organs         Alzheimer Disease          Cancer                 CDSS             constipation
 Ticket: 150.000€
                      Ticket: 75.000€        Ticket: 100.000€      Ticket: 50.000€      Ticket: 100.000€     Ticket: 100.000€

    LIMNO               Aortyx
   Spinoff CSIC
                        Spinoff IQS
                                                 SHBG                  ABLE              CreatSens             DropLite
                                               Spinoff VHIR          Spinoff UPC          Spinoff URV          Spinoff ICFO
 Developing a new
                     Developing a new
    therapy for                              Developing a new      Developing a new     Developing a new     Developing a new
                      device for aortic
      retinitis                             therapy for obesity   exoskeleton for SCI     IVD for CKD           IVD for AH
                         aneurism
   pigmentosa
                                              Ticket: 50.000€      Ticket: 50.000€       Ticket: 50.000€      Ticket: 50.000€
                      Ticket: 100.000€
 Ticket: 125.000€

                                          GENESIS Biomed - Corporate Presentation                                           36
©GENESIS Biomed

Barcelona Office:
Barcelona Science Park
Tower I, offices 3B01-03-05-06                  GENESIS Biomed is member of:
Baldiri Reixac 4-8
08028 Barcelona
+34 93 403 58 53

Madrid Office:
Velázquez 25, 2º A
28001 Madrid

contact@genesis-biomed.com
                                 GENESIS Biomed - Corporate Presentation       37
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