FORMULARY CATALOG 2022 - CRE8 Pharmacy
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TABLE OF CONTENTS Welcome ………………………………………………………………………….. 04 Licensed States ……………………………………………………………….. 05 Hormone Replacement Therapy ………………………………………. 06 The PCAA Advantage 07 HRT Creams & Gels 08 HRT Capsules, Tablets & Troches 09 Testosterone Therapy 10 HGH Therapy 11 Peptide Therapy ……………………………………………………………….. 12 Peptide Dosing Guide 16 Peptide Therapy Info Sheets ……………………………………………. 17 AOD-9604 18 BPC-157 19 CJC-1295 / Ipamorelin 20 Dihexa 21 DSIP (Delta Sleep Inducing Peptide) 22 Epiithalon 23 GHK-Cu 24 IGF-LR3 25 Ipamorelin 26 Kisspeptin-10 27 MK-677 (Ibutamoren) 28 PT-141 (Bremelanotide) 29 Selank 30 Semax 31 Semaglutide 32 Sermorelin Acetate 33 Zinc Thymulin 34 Peptide Therapy Mixing Instructions & Dosing Guide ………. 35 Cognitive & Mental Health ……………………………………………….. 39 Synapsin + RG3 41 Peptide Topical Creams ……………………………………………………. 42 Exclusive Organic Bio Cream 44 Weight Loss & Vitamin Therapy ………………………………………… 45 Glutathione 47 Lipotropic Formulas 48 LIV Injection 49 Semaglutide 50 Vitamin D3 51 Hair Loss Therapy ……………………………………………………………… 52 Sexual Wellness ………………………………………………………………… 54 CRE8 Vitality Nutrition ……………………………………………………… 57 CRE8RX.Online E-Prescribing Portal ………………………………… 63 Additional Peptide References ………………………………………… 65 Contact Us ……………………………………………………………………….. 67 3
WELCOME TO CRE8 PHARMACY Located in Coral Springs, Florida, CRE8 Pharmacy is dedicated to providing the medical community with the highest in quality pharmaceutical compounding services. We are proud to o er compounded medications for personalized medicine to doctors across the USA. We adhere to the guidance provided under section 503A of the Food, Drug, and Cosmetics Act (FDCA). CRE8 Pharmacy is compliant with USP chapters and for non-sterile and sterile compounding practices. We comply with new USP guidelines for the handling of Hazardous Drugs (HD’s). CRE8 Pharmacy believes in o ering outstanding levels of safety and quality compounds provided with exceptional customer service. We strive to provide the highest quality compounds to each individual patient with interactions that elevate the pharmacy experience. Our mission is to be leaders in safety and compliance practices for compounding pharmacies to ensure the best medications for all patients. WE ARE SPECIALISTS Our team brings over four decades of combined experience to the table. We have earned the reputation of industry experts in: designing, building, training, managing and operating compounding pharmacies. Our laboratory and clean room environments are out itted with advanced technology, enabling us to meet the ever- increasing demands for personalized solutions in medicine. Come discover the vast options CRE8 Pharmacy can provide for your patients! Perfectly customized formulas! Oral Administrations (capsules, dissolving troches, liquid suspensions)! Transdermal Applications! Suppositories and Injections (liquid, lyophilized) – start with us today! Our team continuously works to create specialized formulations, dispense orders in a timely fashion and resolve issues promptly. Giving you everything a patient needs shipped in one simple order: • Sterile & Non-Sterile Compounds • Nutritional Supplementation • Generic & Commercial Medications To learn more about our services and our team we encourage you to visit www.cre8pharmacy.com. We look forward to earning your business. Come and discover for yourself why leading physicians across the United States trust and partner with CRE8 Pharmacy due to our authenticity, dependability, excellent customer service and competitive pricing! Here’s to your Health and Vitality, The CRE8 Pharmacy Team Contact us today at 888.224.5181 In an e ort to reduce our carbon footprint, CRE8 Pharmacy will also be releasing the pages of this document digitally. Please consider the environment before printing it out. We only have 1 planet, let’s take care of it! 4 ff ff f ff
LICENSED STATES WE SHIP TO VI PR • Alaska • Maine • Puerto Rico • Arizona • Maryland • Rhode Island • Colorado • Massachusetts • South Dakota • Connecticut • Minnesota • Tennessee • District of Columbia • Missouri • Texas • Delaware • Nevada • Utah • Florida • New Hampshire • Virginia • Georgia • New Jersey • Washington • Hawaii • New Mexico • West Virginia • Iowa • New York • Wisconsin • Idaho • Ohio • Wyoming • Illinois • Oklahoma • Virgin Islands • Indiana • Pennsylvania Map Updated Feb. 1st, 2022 SHIPPING FEES • Ground (Arrives Next Day within Florida) $15.00 • 2nd Day Air $24.00 • Next Day Air $40.00 • Saturday $45.00
HORMONE REPLACEMENT THERAPY THE PCCA ADVANTAGE As a proud member of PCCA (Professional Compounding Centers of America), CRE8 Pharmacy has access to: • Clinical Services team of 20+ full-time pharmacists at our disposal 24/7/365 days a year • Formula Access - 9,400+ formulas, whenever and wherever we need them • Exclusive Bases - compounding vehicles with unmatched performance and reliability • Pharmacy Compounding Education — education, training and support for all sta EXCLUSIVE BASES 70+ PCCA o ers more than 70 high-quality proprietary bases, from leading topical and transdermal technologies to unique oral and nebulization preparations. They bring the brightest minds and the best equipment together to create bases with industry-tested chemical compatibility and superior emulsions. For a complete list of bases for your speci ic needs please contact one of our Physician Liaisons. FORMULATIONS We know that everything from the chemicals to the base to the formula to the support all add up to the inal compounded preparation that can change a life, or even save it. That’s why The PCCA Standard doesn’t just apply to our chemicals and bases; it applies to the formulas we develop and the science behind them, all to help PCCA members con idently and carefully compound prescriptions for their patients. 9400+ Proprietary formulas that help 155+ FormulaPlus™ formulas with extended 45+ Bracketed formulas with achieve positive, reproducible results beyond-use dates (BUD’s) extended BUD’s for your patients PCCA’s Formulation Development PCCA formulas are backed by solid These allow you to use a single formula team creates, monitors and tests science. They have gone through and to create a number of compounds with formulas at the request of PCCA passed stability-indicating testing and are extended BUD’s as long as the API in members or our Clinical Services denoted in our database with the “BUD each compound is within the range of department, and to support new Study” designation in the title and strengths listed in the formula. For PCCA bases and APIs. They also test accompanied by the FormulaPlus™ bracketed formulas, we use a stability- and update our formulas continually, symbol: indicating assay to test the potency of support them with research whenever the low concentration and the high possible, and maintain our Stability-indicating testing methods are concentration of the API(s) in the unparalleled database so that the so precise that they are capable of not formulation over time. This establishes latest versions are always available. only detecting the speci ic API in the the potency over time of the entire preparation, but also the presence of range of strengths for the API. This means that CRE8 Pharmacy has other substances, such as impurities, access to tested, well-supported degradation products and excipients, and compounding formulas that abide by clearly di erentiating between all of them the latest regulations, use new and to provide an incredibly precise measure improved technologies, and of the potency of the API over time, incorporate the most clinically thereby verifying the stability of the relevant bases and APIs to provide preparation. options for patients who need them. 7 ff ff f f f f f
HRT CREAMS & GELS Compounded with PCCA® Exclusive Bases & Ingredients DESCRIPTION FORMULA COMMON STRENGTHS QTY Bi-Estrogen Cream (E2, E3) 50/50 standard strengths 30 g Bi-Estrogen Cream (E2, E3) 50/50 strengths 6%+ 30 g Bi-Estrogen Cream (E2, E3) PLUS 1 HORMONE 50/50 standard strengths 30 g Bi-Estrogen Cream (E2, E3) PLUS 1 HORMONE 50/50 strengths 6%+ 30 g Bi-Estrogen Cream (E2, E3) PLUS 2 HORMONES 50/50 standard strengths 30 g Bi-Estrogen Cream (E2, E3) PLUS 2 HORMONES 50/50 strengths 6%+ 30 g Bi-Estrogen Cream (E2, E3) PLUS 3 HORMONES 50/50 standard strengths 30 g Bi-Estrogen Cream (E2, E3) PLUS 3 HORMONES 50/50 strengths 6%+ 30 g Bi-Estrogen Cream (E2, E3) 80/20 standard strengths 30 g Bi-Estrogen Cream (E2, E3) 80/20 strengths 6%+ 30 g Bi-Estrogen Cream (E2, E3) PLUS 1 HORMONE 80/20 standard strengths 30 g Bi-Estrogen Cream (E2, E3) PLUS 1 HORMONE 80/20 strengths 6%+ 30 g Bi-Estrogen Cream (E2, E3) PLUS 2 HORMONES 80/20 standard strengths 30 g Bi-Estrogen Cream (E2, E3) PLUS 2 HORMONES 80/20 strengths 6%+ 30 g Bi-Estrogen Cream (E2, E3) PLUS 3 HORMONES 80/20 standard strengths 30 g Bi-Estrogen Cream (E2, E3) PLUS 3 HORMONES 80/20 strengths 6%+ 30 g BLT (Benzocaine / Lidocaine / Tetracaine Cream standard strengths 30 g DHEA Cream standard strengths 30 g Estradiol Cream standard strengths 30 g Estradiol Cream strengths 10mg+ 30 g Ketoprofen Cream standard strengths 30 g LT (Lidocaine / Tetracaine Cream standard strengths 30 g Pregnenolone Cream standard strengths 30 g Progesterone Cream standard strengths 30 g Progesterone Cream strengths 210mg+ 30 g Progesterone / Testosterone Cream standard strengths 30 g Progesterone / Testosterone Cream strengths 210mg+ / 210mg+ 30 g Progesterone / Testosterone / Estradiol Cream standard strengths 30 g Progesterone / Testosterone / Estradiol Cream strengths 210mg+ / 210mg+ / 10mg+ 30 g Testosterone Cream standard strengths 30 g Testosterone Cream strengths 210mg+ 30 g Testosterone Cream PLUS 1 HORMONE standard strengths 30 g Testosterone Cream PLUS 1 HORMONE strengths 210mg+ 30 g Tri-Estrogen Cream standard strengths 30 g * Additional strengths and formulas available at Physician’s request. Prices subject to change without notice. 8
HRT CAPSULES, TABLETS & TROCHES 7-Keto DHEA 10 mg Melatonin (available in SR) 2 mg 25 mg 4 mg 50 mg 6 mg Anastrozole 0.25 mg 12 mg 0.5 mg Metformin 250 mg 0.75 mg 500 mg Anastrozole ® 1 mg Naltrexone HCl 3 mg Arimidex ® 1 mg 5 mg Armour Thyroid ® 0.25 Grain (15mg) Naltrexone HCl / B12 10 / 1 mg 0.5 Grain (30mg) NP Thyroid ® 30 mg 1 Grain (60mg) 60 mg 1.5 Grain (90mg) 90 mg 2 Grain (120mg) Oxandrolone 5 mg 3 Grain (180mg) 10 mg Bi-Estrogen (E2, E3) 1 mg 25 mg 5 mg Pregnenolone (available in SR) 10 mg 10 mg 25 mg Chrysin 250 mg 50 mg Clomiphene Citrate 12.5 mg 100 mg 25 mg Progesterone (available in SR) 25 mg 50 mg 50 mg 51 mg 100 mg Cytomel (available in SR) 5 mcg 150 mg 25 mcg 200 mg Cytomel / Anastrozole 12.5 mg / 0.125 mg Synthroid ® 25 mcg Cytomel / Tamoxifen 12.5 mg / 10 mg 50 mcg Danazol (available in SR) 10 mg 75 mcg 25 mg 100 mcg DHEA (available in SR) 5 mg 112 mcg 25 mg Tamoxifen Citrate ® 10 mg 50 mg 20 mg 100 mg Thyroid (Porcine) 15 mg DHEA / Pregnenolone 10 / 25 mg 25 mg 50 / 50 mg 45 mg DMSA 100 mg 50 mg Estradiol 1 mg 100 mg 2 mg Hydrocortisone 2.5 mg 5 mg Letrizole 2.5 mg SUBLINGUAL TROCHES Liothyronine/Levothyroxine 2.25/9.5 mcg 4.5/19 mcg Bi-Estrogen 0-5 mg 9/38 mcg DHEA 10 mg 11/47.5 mcg 50 mg 18/76 mcg Estriol standard strengths Levothyroxine (T4) SR 50 mcg Progesterone 25 mg 100 mcg 100 mg Liothyronine (T3) SR 5 mcg Testosterone 10 mg 10 mcg 50 mg 50 mcg 100 mg * Additional strengths and formulas available at Physician’s request. Prices subject to change without notice. 9
TESTOSTERONE THERAPY INJECTABLES Testosterone Cypionate (Compounded in Sesame Oil) 20mg/mL 5 mL Testosterone Cypionate (Compounded in Sesame Oil) 50mg/mL 4 mL Testosterone Cypionate (Compounded in Sesame Oil) 200mg/mL 4 mL Testosterone Cypionate (Depo-Testosterone P izer) 200 mg/mL 10 mL Testosterone Cypionate (Generic) 200 mg/mL 10 mL Testosterone Enanthate (Compounded in Grapeseed Oil) 200 mg/mL 4 mL Testosterone Enanthate (Brand) 200 mg/mL 5 mL Testosterone Cypionate / Propionate (Compounded in Sesame Oil) 160 / 40 mg/mL 5 mL SUBLINGUAL TROCHES Testosterone 10 mg each 50 mg each 100 mg each CREAMS & GELS Testosterone w/Atrevis™ Gel standard strengths 30 g Testosterone w/Atrevis™ Gel higher strengths 21%+ 30 g Testosterone Cream standard strengths 30 g Testosterone Cream higher strengths 21%+ 30 g Testosterone / Chrysin Cream standard strengths 30 g ATREVIS™ HYDROGEL The next-generation base for testosterone delivery. It has long been assumed that testosterone absorbs well topically from a variety of bases. However, many patients and physicians often report problems with achieving desired testosterone levels in male patients. There are many variables that can a ect these levels in men, and PCCA developed a new base that has proven results for testosterone delivery. Atrevis™ Hydrogel is an advanced topical base designed speci ically to deliver testosterone through the skin in male patients. ADVANCED TECHNOLOGY Atrevis uses a novel delivery system to drive testosterone through the skin, which includes its hydrogel polymer network along with three unique, naturally derived skin-permeation enhancers. This proprietary delivery system was developed speci ically to drive testosterone through the skin. THE PROOF The results of independent testing show that Atrevis Hydrogel signi icantly outperformed both a reference base (hydro-alcoholic surfactant solution) and a competitor base. The results show that: Atrevis™ delivered 2.73 times as much testosterone through the skin as the competitor base Atrevis™ delivered 1.62 times as much testosterone through the skin as the hydro-alcoholic surfactant solution * Additional strengths and formulas available at Physician’s request. Prices subject to change without notice. 10 ff f f f f
HGH THERAPY PRESCRIBING GUIDE FORMAT: Lyophilized powder STRENGTHS AVAILABLE: 5.8mg strength NOTES: With mixing syringe reconstitute powder vial with 1.14ml of STRENGTH IN STRENGTH IN IU bacteriostatic water (included). Inject required dose with MG (= mg x 3) insulin syringes (not included) 5.8mg Vial 17.4 iu INSTRUCTIONS: Click here AVERAGE PRICE PER 1 IU OF HGH: $23.00 FORMAT: Lyophilized powder STRENGTHS AVAILABLE: 5mg & 10mg strengths STRENGTH IN STRENGTH IN IU NOTES: With mixing syringe reconstitute powder vial with 5ml of MG (= mg x 3) bacteriostatic water (included). Inject required dose with insulin syringes (not included) 5mg Vial 15 iu INSTRUCTIONS: Click here 10mg Vial 30 iu AVERAGE PRICE PER 1 IU OF HGH: $23.00 FORMAT: Pre- illed pens STRENGTHS AVAILABLE: STRENGTH IN STRENGTH IN IU 5mg - dose increments of 0.025mg MG (= mg x 3) 10mg - dose increments of 0.05mg 5mg Pen 15 iu 15mg - dose increments of 0.1mg NOTES: No mixing needed. Dial your required dose and inject. 10mg Pen 30 iu Uni-Fine tips not included INSTRUCTIONS: Click here 15mg Pen 45 iu AVERAGE PRICE PER 1 IU OF HGH: $52.00 FORMAT: Pre- illed mini syringes STRENGTH IN STRENGTH IN IU STRENGTHS AVAILABLE: MG (= mg x 3) 0.2mg, 0.4mg, 0.6mg, 0.8mg strengths (Pack of 7) 0.2mg (7pk) 0.6 iu (4.2 iu) NOTES: No mixing needed. Remove safety cap and inject INSTRUCTIONS: Click here 0.4mg (7pk) 1.2 iu (8.4 iu) AVERAGE PRICE PER 1 IU OF HGH: $62.00 0.6mg (7pk) 1.8 iu (12.6 iu) 0.8mg (7pk) 2.4 iu (16.8 iu) INJECTABLES Genotropin Miniquick 0.2 mg 0.6iu 7pk 0.4 mg 1.2iu 7pk 0.6 mg 1.8iu 7pk 0.8 mg 2.4iu 7pk Norditropin FlexPro Pen 5 mg 15iu Each 10 mg 30iu Each 15 mg 45iu Each Omnitrope Vial 5.8mg 17.4iu Each Zomacton Vial 5mg 10iu Each 10mg 30iu Each * Additional strengths and formulas available at Physician’s request. Prices subject to change without notice. 11 f f
PEPTIDE THERAPY 12
PEPTIDE THERAPY INJECTABLES INJECTABLE VIALS COMMON STRENGTHS AOD-9604 600mcg/ml (10ml Vial) BPC-157 (Lyophilized Vial) 10 mg Bremelanotide (PT-141) w/ B6 10,000mcg/50mg/ml (2ml Vial) CJC-1295 / Ipamorelin (Lyophilized Vial) 4/4 mg CJC-1295 / Ipamorelin (Lyophilized Vial) 5/9 mg DSIP (Delta Sleep Inducing Peptide) 1000mcg/ml (3ml Vial) GHK-Cu 10,000mcg/ml (5ml Vial) IGF-LR3 200mcg/ml (5ml Vial) IGF-LR3 / CJC-1295 / Ipamorelin (Lyophilized Vial) 1/6.25/3.75 mg Ipamorelin (Lyophilized Vial) 9 mg Kisspeptin-10 1000mcg/ml (5ml Vial) Semaglutide / BPC-157 / B6 1.25/1.25/40mg/ml (5ml Vial) Sermorelin Acetate (Lyophilized Vial) 9 mg Sermorelin Acetate (Lyophilized Vial) 15 mg CAPSULES CAPSULES COMMON STRENGTHS BPC-157 Capsules 500mcg 1000mcg 1500mcg Dihexa Capsule 2mg 5mg 10mg 25mg Ibutamoren Mesylate (MK-677) Capsules 12.5mg 25mg Ibutamoren Mesylate (MK-677) / BPC-157 Capsules 12.5mg / 1mg Sirolimus Capsule 3mg * Additional strengths and formulas available at Physician’s request. Prices subject to change without notice. 13
PEPTIDE THERAPY SUBLINGUAL TROCHES SUBLINGUAL TROCHES COMMON STRENGTHS AOD-9604 250mcg 500mcg 600mcg AOD-9604 / Ipamorelin 300/300mcg AOD-9604 / Ipamorelin / CJC-1295 300/300/200mcg BPC-157 300mcg 500mcg 1000mcg CJC-1295 300mcg 500mcg CJC-1295 / Ipamorelin 300/300mcg 500/500mcg DSIP 200mcg Epithalon 3mg Epithalon / NAD 3mg/250mg GHK-Cu 1000mcg Ibutamoren Mesylate (MK-677) 12.5mg 25mg Ipamorelin 300mcg 500mcg Kisspeptin-10 200mcg 400mcg Semaglutide 250mcg 500mcg Sermorelin 300mcg 500mcg Sermorelin / Ipamorelin 300/300mcg 600/300mcg * Additional strengths and formulas available at Physician’s request. Prices subject to change without notice. 14
PEPTIDE THERAPY NASAL SPRAYS NASAL SPRAYS COMMON STRENGTHS BPC-157 Nasal Spray 2000mcg/ml (6ml Bottle) Bremelanotide (PT-141) w/ B6 Nasal Spray 5/25mg/ml (10ml Bottle) IGF-LR3 300mcg/ml (6ml Bottle) Selank Nasal Spray 7500mcg/ml (6ml Bottle) Semax Nasal Spray 7500mcg/ml (6ml Bottle) SUPPOSITORIES SUPPOSITORIES COMMON STRENGTHS BPC-157 Suppository 500mcg 1000mcg 1500mcg TOPICAL CREAMS TOPICAL CREAMS COMMON STRENGTHS AOD-9604 Cream 600mcg/ml (30g) BPC-157 Anti-In ammatory Cream 1mg/ml (30g) BPC-157 Organic Bio-Cream 1mg/ml (15ml Pump) BPC-157 w/ GHK-Cu Anti-In ammatory Cream 2mg/2mg/ml (30ml Pump) Dihexa Cream 10mg/ml (15g) 10mg/ml (30g) Dihexa Cream 20mg/ml (15g) 20mg/ml (30g) GHK-Cu Organic Bio-Cream 2mg/g (15ml Pump) 5mg/g (15ml Pump) GHK-Cu w/ BPC-157 Organic Bio-Cream* 2mg/2mg/ml (15ml Pump) 5mg/5mg/ml (15ml Pump) * Additional strengths and formulas available at Physician’s request. Prices subject to change without notice. 15 fl fl
PEPTIDE INDICATION & DOSING GUIDE PEPTIDE INDICATION(s) COMMONLY PRESCRIBED DOSE AOD-9604 (6mg Vial) Weight Loss 300mcg SQ daily for 20 days AOD-9604 500mcg Troche Weight Loss Dissolve 1 troche daily under tongue for 20 days BPC-157 (10mg Vial) Tendon Repair + Ligaments 300mcg SQ daily BPC-157 500mcg Capsule Gut Repair Take one capsule daily BPC-157 1mg/g Organic Bio-Cream Facial Redness, Acne, Skin Issues Apply 1-2 pumps daily for 30 days CJC-1295 500mcg Troche GHRP, Sleep, Energy Dissolve 1 troche under tongue nightly CJC-1295 / Ipamorelin (4/4mg Vial) GHRP, Sleep, Energy, Recovery 200/200mcg SQ 5 days on, 2 days o CJC-1295 / Ipamorelin (5/9mg Vial) GHRP, Sleep, Energy, Recovery 250/450mcg SQ 5 days on, 2 days o CJC-1295 / Ipamorelin 300/300 Troche GHRP, Sleep, Energy, Recovery Dissolve 1 troche under tongue 5 days on 2 days o DIHEXA 2mg Capsule Neurological Function Take one capsule daily DSIP (Delta Sleep Inducing Peptide) 3ml Vial Sleep Assistance 100mcg SQ nightly as needed EPITHALON 3mg Troche Increases Telomere Length, Sleep Dissolve 1 troche under tongue nightly GHK-Cu 5mg/g Organic Bio-Cream Skin Elasticity, Hair Loss Apply 1-2 pumps daily for 30 days GHK-Cu 5mg/g Hair Foam (50ml) Hair Loss Apply 1ml to scalp nightly for 30 days GHK-Cu + BPC-157 2/2mg/g Organic Bio-Cream Skin Elasticity, Hair Loss Apply 1-2 pumps daily for 30 days GHK-Cu 10mg/ml (5ml Vial) Skin Elasticity, Wound Healing 2000-3000mcg SQ nightly as needed IBUTAMOREN (MK-677) 25mg Capsule IGF-1 Increase, Energy, Performance Take one capsule daily IGF-LR3 200mcg/ml (5ml Vial) IGF-1 Increase, Energy, Muscle 30mcg SQ daily for 30 days IGF-LR3 / CJC-1295 / Ipamorelin (1/6.25/3.75 mg) IGF-1 Increase, Energy, Muscle 40/250/150mcg SQ 6 days on, 1 day o IPAMORELIN (9mg Vial) GHRP, Sleep, Energy 300mcg SQ daily for 30 days IPAMORELIN 500mcg Troche GHRP, Sleep, Energy Dissolve 1 troche daily under tongue KISSPEPTIN-10 (5mg Vial) LH Increase 100mcg SQ nightly for 30 days PT-141 w/ B6 10,000mcg/ml (2ml vial) 0.1ml SQ injection 30 minutes to 6 hours prior to Erectile Dysfunction, Libido sexual activity for males (0.2ml for females) PT-141 w/ B6 5,000mcg (10ml Nasal Spray) Erectile Dysfunction, Libido 2-4 sprays per nostril 30-60 minutes prior to sex SELANK 7500mcg/ml (3ml Nasal Spray) Neurological Function, Anxiety 1-2 sprays intranasal daily or as needed SEMAX 7500mcg/ml (3ml Nasal Spray) Neurological Function, Anxiety 1-2 sprays intranasal daily or as needed SEMAGLUTIDE / BPC-157 / B6 (1.25/1.25/40mg/ml) Weight Loss 250mcg/250mcg/8mcg SQ 5 days on, 2 days o SEMAGLUTIDE 500mcg Troche Weight Loss Dissolve 1 troche under tongue nightly SERMORELIN (9mg Vial) GHRP, Sleep, Energy 300mcg SQ nightly for 30 days SERMORELIN (15mg Vial) GHRP, Sleep, Energy 500mcg SQ nightly for 30 days ZINC THYMULIN 50mcg/ml Hair Foam (50ml) Hair Loss Apply 1ml to scalp nightly for 30 days ZINC THYMULIN w/ GHK-Cu 10mcg/5mg/ml Hair Loss Apply 1ml to scalp nightly for 30 days Hair Dropper (30ml) * Additional strengths and formulas available at Physician’s request. Prices subject to change without notice. 16 f f f f f
PEPTIDE THERAPY INFO SHEETS 17
AOD-9604 BENEFITS MAY INCLUDE • Promotes lipolysis without e ecting blood sugar • Less appetite stimulation or tissue growth • Treatment in osteoarthritis, hypercholesterolemia, • Prompts fat release from obese fat cells bone and cartilage repair - results favored when • Prevents lipogenesis (fat accumulation) combined with BPC-157 • Boosts the body’s metabolism BRIEF OVERVIEW AOD-9604 (Advanced Obesity Drug) is a synthetic peptide fragment that comprises a modi ied 15 aminoacid region of GH with a tyrosine component to help stabilize the molecule. It was originally developed by Professor Frank Ng at Monash University in Australia, with the intent of inding an anti-obesity drug that had the fat burning e ects of human growth hormone (HGH) without the muscle-building e ect. Similar to GH, AOD-9604 aids weight reduction in rodent models of obesity and was originally developed for the treatment of obesity in humans. Additionally, it does not stimulate the production of IGF-1, has positive e ects on the di erentiation of adipose mesenchymal stem cells into bone, and was found to promote proteoglycan and collagen production in isolated bovine chondrocytes in an in vitro study. Its positive e ects include promoting the repair of bone and cartilage in cases of OA. COMMONLY PRESCRIBED FORMULAS • AOD-9604 (600mcg/ml) 10ml Vial • AOD-9604 (600mcg/g) Anti-In lammatory Cream • AOD-9604 (500mcg) Sublingual Troche CLINICAL REFERENCES 1. He ernan M, et al. “The E ects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice andβ 3-AR Knock-Out Mice” 2. Stier H, et al. “Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans” Journal of Endocrinology and Metabolism, North America (2013) These statements have not been evaluated by the Food and Drug Administration. These medications are not intended to diagnose, treat, cure or prevent any disease. Additional references available. 18 ff ff ff ff f ff f ff ff f ff
BPC-157 BENEFITS MAY INCLUDE • Supports cognitive performance • Ligament healing (knee, rotary) • Supports joint health • Bene its for ulcers in the stomach • Protects against drug-induced damage • Bene its for intestinal damage • Restores the serotogenic transport system • May help irritable bowel disease • Protects dopaminergic system • Promotes lipolysis • Enhances the GABAergic system • Improves overall skin appearance • Reverse opioid tolerance • Repairs skin barrier proteins • Accelerated wound healing BRIEF OVERVIEW BPC-157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many di erent wounds, including tendons, muscles, nervous system and superior healing of damaged ligaments. Those who su er from discomfort due to muscle sprains, tears and damage may bene it from treatment with this peptide. It can also help aid skin burns to heal at a faster rate and increase blood low to damaged tissues. COMMONLY PRESCRIBED FORMULAS • BPC-157 (10mg) Lyophilized Vial • BPC-157 (500mcg) Capsule • BPC-157 (500mcg) Sublingual Troche • BPC-157 (500mcg) Suppository • BPC-157 (1mg/g) Anti-In lammatory Cream • BPC-157 (1mg/g) Organic Bio-Cream (facial) • GHK-Cu / BPC-157 (2mg/2mg/ml) Organic Bio-Cream (facial) CLINICAL REFERENCES 1. Cerovecki, Tomislav; Bojanic, Ivan; Brcic, Luka; Radic, Bozo; Vukoja, Ivan; Seiwerth, Sven; Sikiric, Predrag (September 2010). "Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat". Journal of Orthopaedic Research. 28 (9): 1155–1161. doi:10.1002/jor.21107. ISSN 1554-527X. PMID 20225319. 2. "Stable gastric pentadecapeptide BPC 157 in trials for in lammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response". PMID 17186181. These statements have not been evaluated by the Food and Drug Administration. These medications are not intended to diagnose, treat, cure or prevent any disease. Additional references available. 19 f f f f f f ff ff
CJC-1295+IPAMORELIN BENEFITS MAY INCLUDE • Promotes lipolysis • Accelerated injury recovery • Improves sleep quality • Improved immune system • Increased energy • Increased protein synthesis • Increased endurance • Increase in lean body mass • Improved cellular repair • Increased collagen production • Increased IGF-1 • Increase in lean body mass • Increased bone density • Less appetite stimulation BRIEF OVERVIEW CJC-1295 is 30 amino acid peptide hormone that has shown promising and amazing results as a Growth Hormone Releasing Hormone (GHRH) analog. CJC-1295 stimulates HGH secretion and can provide a steady increase of HGH with minimal e ect on cortisol and prolactin levels. This means increased protein synthesis thus promoting growth and fat loss simultaneously. Ipamorelin mimics ghrelin and binds to the ghrelin receptor (or GH secretagogue receptor, GHSR) in the brain, thereby selectively stimulating the release of GH from the pituitary gland. This results in increased plasma GH levels, which would a ect many biological processes. Unlike other GH releasing peptides, Ipamorelin only stimulates GH release in a manner very similar to that of growth hormone releasing hormone. This combination results in a great aid for sleep, energy, stamina and recovery bene its. COMMONLY PRESCRIBED FORMULAS • CJC-1295 / Ipamorelin (4/4mg) Lyophilized Vial • CJC-1295 / Ipamorelin (5/9mg) Lyophilized Vial • CJC-1295 / Ipamorelin (300/300mcg) Sublingual Troche CLINICAL REFERENCES 1. Teichman, Sam L.; Neale, Ann; Lawrence, Betty; Gagnon, Catherine; Castaigne, Jean-Paul; Frohman, Lawrence A. (2006). "Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults". The Journal of Clinical Endocrinology & Metabolism. 91 (3): 799–805. doi:10.1210/jc.2005-1536. ISSN 0021-972X. PMID 16352683. 2. Gobburu, Jogarao V. S.; Agersø, Henrik; Jusko, William J.; Ynddal, Lars (1999).Pharmacokinetic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers". Pharmaceutical Research. 16 (9): 1412–1416. doi:10.1023/A:1018955126402. ISSN 0724-8741. These statements have not been evaluated by the Food and Drug Administration. These medications are not intended to diagnose, treat, cure or prevent any disease. Additional references available. 20 ff ff f
DIHEXA BENEFITS MAY INCLUDE • Improves cognitive function • Helps manage depression • Helps in the treatment of Alzheimer’s Disease • Enhances creative thinking and social interaction and Parkinson’s Disease • Improved heart health • Improves long and short-term memory • Improves brain focus BRIEF OVERVIEW Dihexa, also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high a inity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. Dihexa has been found to potently improve cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor. An orally active, blood– brain barrier permeable compound was subsequently developed with the potential to treat Alzheimer’s disease and other disorders that would bene it from augmented synaptic connectivity. COMMONLY PRESCRIBED FORMULAS • Dihexa (2mg) Capsule • Dihexa (5mg) Capsule • Dihexa (20mg/ml) Transdermal Cream (30g) CLINICAL REFERENCES 1. Joseph W. Harding; John W. Wright; Caroline C. Benoist; Leen H. Kawas; Gary A. Wayman (3 December 2013). "Patent US 8598118 - Hepatocyte growth factor mimics as therapeutic agents". Retrieved 11 October 2015. 2. Alene T. McCoy; Caroline C. Benoist; John W. Wright; Leen H. Kawas; Jyote Bule-Ghogare; Mingyan Zhu; Suzanne M. Appleyard; Gary A. Wayman; Joseph W. Harding (January 2013). "Evaluation of metabolically stabilized angiotensin IV analogs as pro-cognitive/anti-dementia agents". The Journal of Pharmacology and Experimental Therapeutics. 344 (1): 141–154. doi:10.1124/jpet.112.199497. PMC 3533412. PMID 23055539. These statements have not been evaluated by the Food and Drug Administration. These medications are not intended to diagnose, treat, cure or prevent any disease. Additional references available. 21 ff f
DSIP (DELTA SLEEP INDUCING PEPTIDE) BENEFITS MAY INCLUDE • Improvement on disturbed sleeping patterns • Decreased production of somatostatin production • Improved LH and GH release • Reduction of chronic pain • Decreased production of cortisol production • Regulation of your circadian rhythm BRIEF OVERVIEW DSIP (Delta sleep-inducing peptide) is a neuromodulator and natural sleep-promoting nonapeptide with many other physiologic functions. It is predominately found in the brain and easily passes the blood-brain barrier. It has been used for the treatment of poor sleep, pain conditions, stress-related symptoms, low testosterone (via stimulation of LH), and even sometimes as an antioxidant and anti-cancer protein. It exhibits a pronounced stress protective action and decreases stress-induced metabolic and functional disorders in human and animal organisms exposed to a variety of stresses. In humans, DSIP is shown to directly impact the secretion of adrenocorticotropic hormone (ACTH), luteinizing hormone (LH) and growth hormone (GH). It may also play a role in the regulation of circadian rhythms. COMMONLY PRESCRIBED FORMULAS • DSIP - Delta Sleep Inducing Peptide (1000mcg/ml) 3ml Vial • DSIP - Delta Sleep Inducing Peptide (200mcg) Troche CLINICAL REFERENCES 1. Abba J.KastinGayle A.OlsonAndrew V.SchallyDavid H.Coy, Alene T. McCoy; Caroline C. Benoist; John W. Wright; Leen H. Kawas; Jyote Bule-Ghogare; Mingyan Zhu; Suzanne M. https://doi.org/10.1016/0166-2236(80)90060-0 2. J M Gimble , A A Ptitsyn, B C Goh, T Hebert, G Yu, X Wu, S Zvonic, X-M Shi, Z E Floyd Delta sleep-inducing peptide and glucocorticoid-induced leucine zipper: potential links between circadian mechanisms and obesity? PMID: 19849801 https://doi.org: 10.1111/j.1467-789X.2009.00661.x These statements have not been evaluated by the Food and Drug Administration. These medications are not intended to diagnose, treat, cure or prevent any disease. Additional references available. 22
EPITHALON BENEFITS MAY INCLUDE • Regulates cell cycle through telomerase activity • Activate gene expression and protein synthesis in up-regulation speci ic target tissues • Increases and restores telomere length • Activates chromatin which its primary function is • Improves glucose tolerance and decreases insulin and packaging long DNA molecules into more compact, triglyceride levels denser structures • Improvement on disturbed sleeping patterns BRIEF OVERVIEW Epithalon (also known as Epitalon) is the synthetic version of the polypeptide Epithalamin which is naturally produced in humans. The pineal peptide preparation is secreted in the epithalamium-epiphyseal region of the brain. It is used to regulate metabolism in the epiphysis, increase the sensitivity of hypothalamus to its natural hormonal in luences, normalize the function of the anterior pituitary, regulate the levels of gonadotropins and melatonin in the body. Epithalamin increases a person's resistance to emotional stress and also acts as an antioxidant. It is a bio-regulator for the endocrine system, especially for the pineal gland, and has been shown to lengthen telomeres in human cells. The mechanisms in Epitalon’s primary role is to increase the natural production of telomerase, a natural enzyme that helps cells reproduce telomeres, which are the protective parts of our DNA. This allows the replication of our DNA so the body can grow new cells and rejuvenate old ones. It reduces lipid oxidation and ROS, along with normalizing T cell function. It seems to normalize cholesterol and uric acid, along with prolactin levels. It has shown promise in restoring pancreatic hormone function. Epithalon can also restore and normalize melatonin levels in older patients who have lost some pineal function due to aging. COMMONLY PRESCRIBED FORMULAS • Epithalon - (3mg) Sublingual Troche • Epithalon / NAD - (3mg / 250mg) Sublingual Troche • Epithalon Nasal Spray (300mcg/ml) 6ml Bottle CLINICAL REFERENCES 1. Christensen, K., Thinggaarda, M., McGue, M., Rexbye, H., Hjelmborg, J.B., Aviv, A., … Vaupel, J.W. (2009). Perceived age as a clinically useful biomarker of aging: cohort study. Bio Medical Journal (online). 339:b5262. 2. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells V Kh Khavinson 1, I E Bondarev, A A Butyugov A iliationsexpand PMID: 12937682 DOI: 10.1023/a:1025493705728 3. Khavinson VK, et al. Byulleten’ Eksperimental’noi Biologii i Meditsiny, Peptide Geroprotector from the Pituitary Gland Inhibits Rapid Aging of Elderly People: Results of 15-Year Follow-UpVol. 151, No. 3, pp. 343- 347, March, 2011 These statements have not been evaluated by the Food and Drug Administration. These medications are not intended to diagnose, treat, cure or prevent any disease. Additional references available. 23 f f ff
GHK-CU BENEFITS MAY INCLUDE • Improved skin elasticity and irmness • Improves wound healing and reduce infections • Reduces hyper-pigmentation and skin spots • Increases hair growth and follicle size • Stimulates skin collagen • Increase production of stem cells • Improves overall skin appearance • Bone Repair • Reduces in lammation • Antimetastatic properties BRIEF OVERVIEW GHK-Cu is a tripeptide with the amino acid sequence glycyl-histidyl-lysine. It naturally occurs in human plasma. It has also been found in saliva, and urine. In plasma the level of GHK declines as you age. This decline in the GHK-level coincides with the noticeable decrease in regenerative capacity of an organism. GHK-Cu functions as a complex with copper stimulates collagen production, accelerates wound healing and contraction, improves the take of transplanted skin, and also possesses anti- in lammatory properties. COMMONLY PRESCRIBED FORMULAS • GHK-Cu (5mg/ml) Organic Bio-Cream (facial) • GHK-Cu (5mg/ml) Hair Foam (50ml Bottle) • GHK-Cu / BPC-157 (2mg/2mg/ml) Organic Bio-Cream (facial) • GHK-Cu (10,000mcg/ml) 5ml Vial • Zinc Thymulin w/ GHK-Cu (10mcg/5mg/ml) Hair Foam (50ml Bottle) • Zinc Thymulin w/ GHK-Cu (50mcg/5mg/ml) Hair Foam (50ml Bottle) • Zinc Thymulin w/ GHK-Cu (10mcg/5mg/ml) Hair Dropper (30ml Bottle) • Zinc Thymulin w/ GHK-Cu (50mcg/5mg/ml) Hair Dropper (30ml Bottle) CLINICAL REFERENCES 1. L. Pickart, J. H. Freedman, W. J. Loker et al., “Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells,” Nature, vol. 288, no. 5792, pp. 715–717, 1980. 2. D. Downey, W. F. Larrabee Jr., V. Voci, and L. Pickart, “Acceleration of wound healing using glycyl-histidyl-lysine copper (II),” Surgical Forum, vol. 25, pp. 573–575, 1985. 3. H. Ehrlich, “Stimulation of skin healing in immunosuppressed rats,” in Proceedings of the Symposium on Collagen and Skin Repair, Reims, France, September 1991. These statements have not been evaluated by the Food and Drug Administration. These medications are not intended to diagnose, treat, cure or prevent any disease. Additional references available. 24 f f f
IGF-LR3 BENEFITS MAY INCLUDE • Helps production of protein synthesis in the body • Up-regulates anti-oxidant bene its • It regulates the storage of fat and distributes it to be used • Helps in the development of hyperplasia in muscle cells, for the production of energy. which lead to fuller muscle tissues • Increases lean body mass and decreases fat • Increases the regenerative properties of the body’s nerve tissues. BRIEF OVERVIEW IGF-LR3 is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1). It di ers from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence ("arginine 3"), and also has an additional 13 amino acids at its N-terminus ("long"), for a total of 83 amino acids (relative to the 70 of IGF-1). The consequences of these modi ications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low a inity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability. As a result, it is approximately three times more potent than IGF-1, and possesses a signi icantly longer half-life of about 20–30 hours (relative to IGF-1's half-life of about 12–15 hours). IGF-1 LR3 (insulin-like growth factor-1 long arginine 3) is a synthetic, modi ied construct of insulin-like growth factor-1. Because IGF-1 LR3 does not bind to IGF-1 binding proteins very well, it remains active up to 120 times longer than standard IGF-1. This results in improved half-life for the peptide and thus increased activity. IGF-1 LR3 enhances cell division and growth, boosts fat metabolism, and increases muscle repair and hypertrophy by inhibiting myostatin. IGF-1 LR3 inhibits the movement of glucose into the body cells which facilitates fat burning and the use of fat in the body for the production of energy. COMMONLY PRESCRIBED FORMULAS • IGF-LR3 (200mcg/ml) 5ml Vial • IGF-LR3 (300mcg/ml) Nasal Spray 6ml Bottle CLINICAL REFERENCES 1. Tomas FM, Lemmey AB, Read LC, Ballard FJ (1996). "Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injection". J. Endocrinol. 150 (1): 77–84. doi:10.1677/joe.0.1500077. PMID 8708565.^ 2. Mohan S, Baylink DJ (2002). "IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms". J. Endocrinol. 175 (1): 19– 31. doi:10.1677/joe.0.1750019. PMID 12379487. 3. ^ Tomas FM, Knowles SE, Owens PC, Chandler CS, Francis GL, Read LC, Ballard FJ (1992). "Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats". Biochem. J. 282 ( Pt 1): 91–7. doi:10.1042/bj2820091. PMC 1130894. PMID 1371669. These statements have not been evaluated by the Food and Drug Administration. These medications are not intended to diagnose, treat, cure or prevent any disease. Additional references available. 25 ff f f f ff f
IPAMORELIN BENEFITS MAY INCLUDE • Promotes lipolysis • Improved cellular repair • Increased collagen production • Increased IGF-1 • Increase in lean body mass • Counteracts glucocorticoid catabolic e ects • Improves sleep quality • Less appetite stimulation • Increased energy • Less release of cortisol, prolactin and aldosterone • Increased endurance BRIEF OVERVIEW Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) and a ghrelin mimetic with growth hormone (GH) releasing activity. Ipamorelin mimics ghrelin and binds to the ghrelin receptor (or GH secretagogue receptor, GHSR) in the brain, thereby selectively stimulating the release of GH from the pituitary gland. This results in increased plasma GH levels, which would a ect many biological processes. Besides its presence in the brain, GHSR can also be found in the gastrointestinal tract, heart, lung, liver, kidney, pancreas, adipose tissue and immune cells. Unlike other GH releasing peptides, Ipamorelin only stimulates GH release in a manner very similar to that of growth hormone releasing hormone. COMMONLY PRESCRIBED FORMULAS • Ipamorelin (9mg) Lyophilized Vial • Ipamorelin (300mcg) Sublingual Troche • CJC-1295 / Ipamorelin (4/4mg) Lyophilized Vial • CJC-1295 / Ipamorelin (5/9mg) Lyophilized Vial CLINICAL REFERENCES 1. Gobburu, Jogarao V. S.; Agersø, Henrik; Jusko, William J.; Ynddal, Lars (1999).Pharmacokinetic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers". Pharmaceutical Research. 16 (9): 1412–1416. doi:10.1023/A:1018955126402. ISSN 0724-8741. 2. Raun, K; Hansen, B.; Johansen, N.; Thogersen, H; Madsen, K; Ankersen, M; Andersen, P. (1998). "Ipamorelin, the irst selective growth hormone secretagogue". European Journal of Endocrinology. 139 (5): 552–561. doi:10.1530/eje.0.1390552. ISSN 0804-4643. These statements have not been evaluated by the Food and Drug Administration. These medications are not intended to diagnose, treat, cure or prevent any disease. Additional references available. 26 ff f ff
KISSPEPTIN-10 BENEFITS MAY INCLUDE • Evokes luteinizing hormone secretion • Reverse e ects of hypogonadotropic hypogonadism • Increases Testosterone • Increases aldosterone production • Increases follicle stimulating hormone • Improves cognitive function • Increased energy • Bene icial for low libido (male & female) BRIEF OVERVIEW Kisspeptins are a family of peptide hormones, which have been shown to play a critical role in the regulation of the hypothalamic– pituitary–gonadal axis, thus in luencing fertility and reproduction. In 1996, a research team at the University of Pennsylvania (Hershey, PA, USA) irst identi ied the Kisspeptin gene (KISS1 - named after the most famous local product Hershey’s Kisses ) for its anti-metastatic properties in malignant melanoma . Later on Kisspeptin-based studies have identi ied a role in idiopathic hypogonadotrophic hypogonadism, hypothalamic amenorrhoea, hyperprolactinaemia, in vitro fertilisation, polycystic ovarian syndrome and psychosexual disorders. COMMONLY PRESCRIBED FORMULAS • Kisspeptin-10 (1000mcg/ml) 5ml Vial • Kisspeptin-10 (200mcg) Troche • Kisspeptin-10 (400mcg) Troche CLINICAL REFERENCES 1. J. T. George, J. D. Veldhuis, A. K. Roseweir, C. L. Newton, E. Faccenda, R. P. Millar,* and R. A. Anderson; “Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency in Men”; doi: 10.1210/jc.2011-0089 2. C. N. Jayasena , A. N. Comninos , J. D. Veldhuis, S. Misra, A. Abbara, C. Izzi‐Engbeaya, M. Donaldson, M. A. Ghatei, S. R. Bloom, W. S. Dhillo; “A single injection of kisspeptin‐54 temporarily increases luteinizing hormone pulsatility in healthy women”; doi.org/10.1111/cen.12179 These statements have not been evaluated by the Food and Drug Administration. These medications are not intended to diagnose, treat, cure or prevent any disease. Additional references available. 27 f ff f f f f
MK-677 (IBUTAMOREN) BENEFITS MAY INCLUDE • Promotes lipolysis • Increased endurance • Increased bone density • Improved cellular repair • Increase in lean body mass • Increased IGF-1 • Increase muscle mass • Supports cognitive performance • Improves sleep quality • Supports joint health • Increased energy BRIEF OVERVIEW Ibutamoren (MK-677) is a potent, long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. It has been shown to increase the secretion of several hormones including GH and insulin-like growth factor 1 (IGF-1) and produces sustained increases in the plasma levels of these hormones without a ecting cortisol levels. COMMONLY PRESCRIBED FORMULAS • Ibutamoren (MK-677) 12.5mg Capsule • Ibutamoren (MK-677) 25mg Capsule • Ibutamoren (MK-677) 25mg Troche CLINICAL REFERENCES 1. Patchett AA, Nargund RP, Tata JR, Chen MH, Barakat KJ, Johnston DB, Cheng K, Chan WW, Butler B, Hickey G (July 1995). "Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue". Proceedings of the National Academy of Sciences of the United States of America. 92 (15): 7001–5. doi:10.1073/pnas.92.15.7001. PMC 41459. 2. Chapman IM, Pescovitz OH, Murphy G, Treep T, Cerchio KA, Krupa D, Gertz B, Polvino WJ, Skiles EH, Pezzoli SS, Thorner MO (October 1997). "Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-de icient adults". The Journal of Clinical Endocrinology and Metabolism. 82 (10): 3455–63. doi:10.1210/jc.82.10.3455. PMID 9329386. These statements have not been evaluated by the Food and Drug Administration. These medications are not intended to diagnose, treat, cure or prevent any disease. Additional references available. 28 ff f
PT-141 (BREMELANOTIDE) BENEFITS MAY INCLUDE • HSDD (hypoactive sexual desire disorder) in • Bene icial for ED (erectile dysfunction) premenopausal women • Helps enhance sexual satisfaction • Bene icial for low libido (male & female) • Skin pigmentation (sunless tanning agent) • Increase energy BRIEF OVERVIEW PT-141 (Bremelanotide) is a synthetic peptide developed from Melanotan 2 (MT-II). PT-141 is used for the treatment of erectile dysfunction or impotence in men and HSDD (hypoactive sexual desire disorder) in women. PT-141 is a peptide that was originally developed as a sunless tanning agent. It is a melanocyte stimulating hormone (MSH) that a ects sexual arousal, aiding enhanced libido levels and penile erections. Unlike all PDES inhibitors, PT-141 does not target the vascular system. Instead, it acts on the nervous system via activation of neurons in the hypothalamus to increase sexual desire. COMMONLY PRESCRIBED FORMULAS • Bremelanotide (PT-141) 10,000mcg/ml w/ B6 50mg/ml - 2ml Vial • Bremelanotide (PT-141) w/B6 (5/25mg/ml) Nasal Spray 10ml Bottle CLINICAL REFERENCES 1. Shadiack AM, Sharma SD, Earle DC, Spana C, Hallam TJ. 2007;7(11):1137-44. Melanocortins in the treatment of male and female sexual dysfunction. 2. Rosen RC1, Diamond LE, Earle DC, Shadiack AM, Molinoff PB 2004 Apr;16(2):135-42. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. These statements have not been evaluated by the Food and Drug Administration. These medications are not intended to diagnose, treat, cure or prevent any disease. Additional references available. 29 f f ff
SELANK BENEFITS MAY INCLUDE • Superior learning aptitude and memory processes • Better antiviral functioning without any adverse side • Better sensory awareness e ects • Improved curiosity • Improved cerebral energy • Enhanced mental concentration • Better and steady mood as well as feelings of grati ication • Regulation of the activities of noradrenergic and and happiness. serotonergic brain systems • Decreased anxiety and stress levels BRIEF OVERVIEW Selank is a heptapeptide which is a derivative of tetra-peptide Tuftsin. The human body produces Tuftsin naturally which comes with a broad range of bene its. The Institute of Molecular Genetics of the Russian Academy of Science initially synthesized Selank during the late 1990’s. Stage III clinical tests were quite successful in Russia. It is one of the latest substances used for its many anti-anxiety (anxiolytic) e ects. Selank is a precursor to the tetrapeptide known as Tuftsin. This tetrapeptide can e iciently improve and transform your immune system. COMMONLY PRESCRIBED FORMULAS • Selank (7500mcg/ml) Nasal Spray 6ml Bottle CLINICAL REFERENCES 1. Uchakina, O. N.; Uchakin, P. N.; Miasoedov, N. F.; Andreeva, L. A.; Shcherbenko, V. E.; Mezentseva, M. V.; Gabaeva, M. V.; Sokolov, O. U.; Zozulia, A. A.; Ershov, F. I. (2008). "Immunomodulatory e ects of selank in patients with anxiety-asthenic disorders". Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova. 108 (5): 71–75. PMID 18577961. 2. Semenova, T. P.; Kozlovskiĭ, I. I.; Zakharova, N. M.; Kozlovskaia, M. M. (2009). "Comparison of the e ects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA". Eksperimental'naia i klinicheskaia farmakologiia. 72 (4): 6–8. PMID 19803361. These statements have not been evaluated by the Food and Drug Administration. These medications are not intended to diagnose, treat, cure or prevent any disease. Additional references available. 30 ff ff ff f f ff ff
SEMAX BENEFITS MAY INCLUDE • Enhanced mental concentration • Improved Glaucoma Optic Neuropathy • Increased attention and short-term memory • Helpful in the treatment of ADHD • Increased brain BDNF levels • Nootropic (cognitive-enhancing) e ects • Reduces breakdown of enkephalins • Neuroprotection: may help protect the brain from • Improved Non-proliferative Diabetic Neuropathy various types of stress and damage • Can help during recovery from Stroke/Hypoxia • Decreased anxiety and stress levels BRIEF OVERVIEW Semax is a peptide known best for its nootropic, neurogenic/neurorestorative and neuroprotective properties. It is a modi ied snippet of a hormone called adrenocorticotropic hormone (ACTH). Semax is the basis for a number of drugs that are used in clinical practice for the treatment of CNS diseases (ischemic brain stroke, dys-circulatory encephalopathy, optic nerve atrophy, etc.) and to enhance adaptability under extreme conditions in healthy persons. Heptapeptide SEMAX (MEHFPGP) is the analogue of ACTH (4-10) that has prolonged neurotropic activity and thus is a good candidate for medical therapy. Currently this peptide is successfully used in treatment of patients with pathologies related to brain circulation dysfunction and with di erent intellectual- amnestic problems of the CNS. Doctors have prescribed it for many conditions like anxiety, memory improvement, ischemic events, stroke, nerve regeneration, ADHD, opioid withdrawal, and even chronic diseases such as ALS, Parkinson’s, and Alzheimer’s. COMMONLY PRESCRIBED FORMULAS • Semax (7500mcg/ml) Nasal Spray 6ml Bottl CLINICAL REFERENCES 1. Shih-Jen Tsai - Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-de icit hyperactivity disorder and Rett syndrome PMID: 16996699 DOI: 10.1016/j.mehy.2006.07.017 2. G S Polunin, S M Nurieva, D L Baiandin, N L Sheremet, L A Andreeva - Evaluation of therapeutic e ect of new Russian drug semax in optic nerve disease] PMID: 10741256 These statements have not been evaluated by the Food and Drug Administration. These medications are not intended to diagnose, treat, cure or prevent any disease. Additional references available. 31 ff e ff f ff f
SEMAGLUTIDE BENEFITS MAY INCLUDE • Promotes lipolysis • Lowers BMI • Improves blood sugar levels in adults with Type 2 diabetes • Plaque hemorrhage is reduced • Lowers A1C • Helps pancreatic insulin release to lower glucose levels in • Cardiovascular bene its - lowers risk of cardiovascular the bloodstream events such as heart attacks & strokes BRIEF OVERVIEW Semaglutide is a glucagon-like peptide (GLP-1) analog as an FDA approved treatment method for improving glycemic control in patients with Type 2 diabetes. It increases insulin secretion, which is good for diabetes. At higher doses, it can act on centers in the brain and help suppress appetite. Used in conjunction with lifestyle changes and a reduced-calorie diet, Semaglutide can have a very successful outcome with weight loss and lowering high blood pressure. Studies show that Semaglutide can reduce appetite, improved control of eating, and reduce food cravings in addition to improved glycemic control. Some studies show negative side e ects that may include nausea, diarrhea and even vomiting. The inclusion of BPC-157 and Pyridoxine (B6) may help decrease nausea e ect. COMMONLY PRESCRIBED FORMULAS • Semaglutide / BPC-157 / B6 (1.25mg/1.25mg/40mg/ml) - 5ml Vial • Semaglutide (250mcg) Sublingual Troche • Semaglutide (500mcg) Sublingual Troche CLINICAL REFERENCES 1. John P.H. Wilding, D.M., Rachel L. Batterham, M.B., B.S., Ph.D., Salvatore Calanna, Ph.D., Once-Weekly Semaglutide in Adults with Overweight or Obesity DOI: 10.1056/NEJMoa2032183 2. Robert F. Kushner 1, Salvatore Calanna2, Melanie Davies3,4,5, Dror Dicker6,7, W. Timothy Garvey 8,9, Bryan Goldman2, Ildiko Lingvay10,11, Mette Thomsen2, Thomas A. Wadden12, Sean Wharton 13, John P.H. Wilding14, and Domenica Rubino15 - Semaglutide 2.4 mg for the Treatment of Obesity: 3. Yuko Tashiro, Kengo Sato, Takuya Watanabe, Kyoko Nohtomi, Michishige Terasaki, Masaharu Nagashima, Tsutomu Hirano, A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atherosclerosis, Peptides,Volume 54, 2014, Pages 19-26, ISSN 0196-9781, These statements have not been evaluated by the Food and Drug Administration. These medications are not intended to diagnose, treat, cure or prevent any disease. Additional references available. 32 ff ff f
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