Dietary Management of Type 2 Diabetes Resource Pack - Thames Valley Dietitian Forum September 2019
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Table of contents Background…………………………………………………………………………………………………………. 5 Reviewing and updating………………………………………………………………………………………. 5 Decision tree…………….………………………………………………………………………………………… 6 Step 1: Referring to local structured education………………………………………………. 7 Step 2: Providing Diabetes UK booklets………………………………………………………….. 8 Step 3: Referring to local weight management services…………………………………… 9 Step 4: Weight loss resources………………………………………………………………………… 10 4.1 Low energy diets…………………..……………………………………………………………. 11 4.2 Low carbohydrate diets………………………………………………………………………. 13 4.3 Mediterranean-style diets………………………………………………………………….. 15 4.4 Low fat, healthy eating……………………………………………………………………….. 16 4.5 Intermittent fasting …………………………………………………………………………… 18 4.6 Low glycaemic index diets………………………………………………………………….. 19 Evidence review……….…………………………………………………………………………………………. 20 Low energy diets………………….…………………………………………………………….. 21 Low carbohydrate diets……………….……………………………………………………… 22 Mediterranean-style diets………………………………………………………………….. 25 Low fat, healthy eating……………………………………………………………………….. 26 Intermittent fasting …………………………………………………………………………… 27 Low glycaemic index diets…………………………………………………………………… 28 References………………………...……………………………………………………………………………….. 28 Appendix 1. Local structured education programmes…………………………………………. 33 Berkshire…………………………………………………………………………………………… 33 Buckinghamshire………………………………………………………………………………… 35 Frimley Health……………………………………………………………………………………. 36 Oxfordshire……………………………………………………………………………………….. 37 Appendix 2. Local weight management programmes………………………………………….. 38 Berkshire………………………………………………………………………………………… 38 Buckinghamshire…………………………………………………………………………….. 40 Dietary management of type 2 diabetes Page 2 of 40 TVDF resource pack. September 2019. Final v1
Frimley Health………………………………………………………………………………… 42 Oxfordshire………………………………………………………………………………………. 43 Appendix 3. Medication adjustment for low carbohydrate and low energy diets…. 45 Appendix 4. Medication adjustment for intermittent fasting……………………………….. 48 Appendix 5. Handouts with information about resources……………………………………. 49 Low energy diets………………….…………………………………………………………… 50 Low carbohydrate diets……………….……………………………………………………. 51 Mediterranean-style diets…………………………………………………………………. 52 Low fat, healthy eating……………………………………………………………………… 53 Intermittent fasting …………………………………………………………………………. 54 Members of Thames Valley Dietitian Forum………………………………………………………… 55 Supplement 1. Low carbohydrate diet Supplement 2. Mediterranean-style diet Dietary management of type 2 diabetes Page 3 of 40 TVDF resource pack. September 2019. Final v1
Abbreviations CER Continuous energy restriction CVD Cardiovascular disease GI Glycaemic index IF Intermittent fasting LCHF Low carbohydrate high fat LED Low energy diet MD Mediterranean diets MHRA Medicines and healthcare products regulatory agency NICE National institute for health and care excellence SACN Scientific advisory committee on nutrition SFA Saturated fatty acids TDR Total diet replacement TVDF Thames Valley dietitian forum VLED Very low energy diet This resource pack has been produced by the Thames Valley Strategic Clinical Network (TVSCN) Dietitian Forum on behalf of the TVSCN Diabetes Network. For further details about the TVSCN and/or this resource pack please contact Julia Coles, Senior Clinical Network Manager, TVSCN. Email: julia.coles1@nhs.net Dietary management of type 2 diabetes Page 4 of 40 TVDF resource pack. September 2019. Final v1
Background People with type 2 diabetes attempting to lose weight, improve glycaemic control and reduce their risk of cardiovascular disease (CVD) have a wide variety of dietary strategies to choose from, and it is essential that they receive evidence-based advice from health care professionals. The Thames Valley Dietitian Forum (TVDF) supports the view of Diabetes UK that there is an extensive variety of dietary strategies that have shown to be effective in type 2 diabetes1, and it is committed to offering individualised, evidence-based advice. Information is disseminated in many different ways; verbally, through resources such as diet sheets and books and digitally either online or through apps, although not all available advice has a robust evidence base. In order to ensure that people with diabetes are able to make informed choices about personal dietary strategies, the TVDF has formulated an evidence review for a selection of widely available resources, and this has been synthesised into recommendations supported by resources where applicable. A decision tree is provided for reference, and each action is supported with a description of available resources and how to access them. The full evidence base for all resources has been produced and is available to reinforce appropriate advice. Reviewing and updating New dietary resources are constantly being developed and disseminated, and the TVDF is committed to reviewing and updating the resource pack as necessary using the following protocol: The resource pack will be reviewed and updated at six-monthly intervals Any new resources will be submitted to the TVDF At least two dietitians from different areas will review the resource An evidence-based report will be compiled Following a positive report, the resource will be included in the next iteration of the resource pack Dietary management of type 2 diabetes Page 5 of 40 TVDF resource pack. September 2019. Final v1
Dietary management of type 2 diabetes: Decision tree 1 See page 6 2 See page 11 3 See page 12 4 See page 19 Dietary management of type 2 diabetes Page 6 of 40 TVDF resource pack. September 2019. Final v1
Step 1: Referring to local structured education Structured education is the foundation for effective self-management and is recommended by NICE2 and by Diabetes UK1 at the time of diagnosis and with annual reinforcement. Details of local available programmes, by region, can be found in Appendix 1, page 33: Index to structured education programmes Area Page Berkshire: Berkshire East……………………………………………………. 33 Berkshire West………………………………………………….. 34 Buckinghamshire……………………………………………………… 35 Frimley Health: NE Hants & Farnham…………………………………………. 36 Surrey Heath……………………………………………………… 36 Oxfordshire……………………………………………………………… 37 A new national programme, Healthy Living for People with Type 2 Diabetes (HeLP Diabetes) will be available from early 2020. HeLP Diabetes is an online self-management support programme and accompanying structured education pathway for adults with type 2 diabetes and was originally developed by a team at University College London (UCL). It provides information about type 2 diabetes and its treatments, offers emotional support, and helps with adopting and maintaining healthy behaviours (diet and physical activity). HeLP offers an alternative means of accessing support alongside more traditional group based structured education programmes, and is intended to increase access to these services. More information is available at: https://www.england.nhs.uk/diabetes/digital-innovations-to-support-diabetes-outcomes/help- diabetes/ Dietary management of type 2 diabetes Page 7 of 40 TVDF resource pack. September 2019. Final v1
Step 2: Providing Diabetes UK booklet For those who do not wish or are unable to attend local structured education groups and who have a BMI
Step 3: Signposting local weight management groups Local weight management groups, which are free at the point of delivery, are available in the Thames Valley. For details, please see Appendix 2, page 38. Index to structured weight management programmes Area Page Berkshire: Berkshire East………………………………………………… 38 Berkshire West………………………………………………… 39 Buckinghamshire 40 Frimley Health: NE Hants & Farnham……………………………………… 42 Surrey Heath…………………………………………………… 42 Oxfordshire…………………………………………………………… 43 Dietary management of type 2 diabetes Page 9 of 40 TVDF resource pack. September 2019. Final v1
Step 4: Offering weight loss advice If local weight management services or groups are not available, or if people with type 2 diabetes are unwilling or unable to attend, individualised weight management advice can be offered. It is best practice to ensure that all dietary support is evidence-based and conforms with guidelines. Evidence-based advice for weight loss in those with type 2 diabetes includes: − low energy (calorie) diets − low carbohydrate diets − Mediterranean-style diets − general healthy, low fat eating combined with a degree of energy restriction. There is also more limited evidence to support the use of intermittent fasting. The full evidence review of these diets is available on page 20. There are a variety of commonly available resources to support these different strategies, and the range of resources recommended below reflects the decision of the expert dietitian group, and is not necessarily exhaustive. Those that have been considered are those that are commonly mentioned by people with diabetes during consultations, although some frequently used resources are not included due to insufficient evidence. Printable leaflets including a full list and brief description of each of the recommended resources for each individual dietary strategy are available in Appendix 5, page 49. Index to printable handouts Dietary strategy Page Low energy diets…………………………………………………………. 50 Low carbohydrate diets………………………………………………… 51 Mediterranean-style diets…………………………………………… 52 Low fat, healthy eating…………………………………………………. 53 Intermittent fasting……………………………………………………… 54 Dietary management of type 2 diabetes Page 10 of 40 TVDF resource pack. September 2019. Final v1
4.1 Low energy diets Low energy diets typically provide 800-1200 kcal/day from food, meal replacement products (shakes, bars and soups) or a combination of the two. The evidence review is available on page 21. Total diet replacement Recent studies such as the DiRECT and DROPLET trials used a short period (12-24 weeks) of total diet replacement (TDR) using formula foods, followed by structured food reintroduction and weight management programmes. Although they have reported positive effects, it is important to remember that these are structured behavioural interventions designed to maintain weight loss over the long-term, and not simply a short- term intervention. At present, only Counterweight Plus (used in DiRECT) and the Cambridge Weight Plan (DROPLET) have a strong evidence base. If people with type 2 diabetes wish to adopt a TDR strategy, this is as yet unavailable on the NHS, and they will need to self-fund. Currently, the NHS is rolling out a TDR programme and this may be available in some areas in the near future. People adopting TDR require proactive medication adjustment, see Appendix 3, page 45. Name Description Cost Contact details Counterweight Plus 12 weeks of TDR using branded products followed by Approximately £100 https://www.counterweight.org food reintroduction and weight maintenance support per month The 1:1 diet 12 weeks of TDR using branded shakes, bars and Approximately £50 https://www.one2onediet.com/abou (Cambridge Weight soups followed by structured food reintroduction per week during t-us Plan) under personal supervision of a counselllor TDR, then ~£30 pw Lighter Life 8 weeks of TDR using branded Foodpacks (shakes, Approximately £70 https://www.lighterlife.com bars, soups, pasta) followed by structured food per week during TDR reintroduction. Both personal counsellors and groups are offered Optifast 8-12 weeks of TDR using branded shakes and soups Approximately £60 https://www.nestlehealthscience.co. followed by food reintroduction per week uk/optifast/home Dietary management of type 2 diabetes Page 11 of 40 TVDF resource pack. September 2019. Final v1
Food based diets Food-based low energy diets were used in most of the early studies, including UKPDS, but have fallen out of fashion recently with the introduction of meal replacements. However evidence from these early studies indicate that they are effective. People choosing this strategy are advised to monitor blood glucose levels and may require proactive medication adjustment, see Appendix 1. Recommended resources include: Name Description Cost Contact details Diabetes UK online Online 1200 kcal/day, nutrient-dense diets that and Free https://www.diabetes.org.uk/guide- energy-restricted diets are high in fruit and vegetables and dietary fibre and to-diabetes/enjoy-food/eating-with- low in saturated fat. They offer 7-day menu plans diabetes/meal-plans with recipes for both meat-eaters and vegetarians Dietary management of type 2 diabetes Page 12 of 40 TVDF resource pack. September 2019. Final v1
4.2 Low carbohydrate diets There is no consensus on the definition of low carbohydrate diets, but a low a carbohydrate diet is usually assumed to provide
Low carb diabetes Cookbook authored by David Cavan £14.99 https://www.penguin.co.uk/books/111/1113968/the- cookbook (diabetes consultant) and Emma Porter (Available at low-carb-diabetes-cookbook/9781785041402.html (food writer and person with type 1 cheaper prices at diabetes). Promoted as a method of Amazon) managing type 1 diabetes and reversing type 2 diabetes, although management of type 2 diabetes is also included. Recommends limiting carbohydrate intake to 50-100g/day and provides recipes and meal plans Carbs and Cals/World Books and apps. These resources are Books £9.99 https://www.carbsandcals.com Foods designed for those who wish to Apps £4.99 carbohydrate and calorie count. They are not designed for stand-alone use, but are useful for supporting a specific energy or carbohydrate restriction Low carbohydrate Diet sheet Free Available at the back of this resource pack (
4.3 Mediterranean-style diets The Mediterranean diet (MD) reflects the culinary traditions of people living in countries bordering the Mediterranean sea and is characterised by higher intakes of vegetables, fruits, legumes, nuts, beans, cereals, grains, fish and unsaturated fats such as olive oil. It is not, however, a licence to eat unlimited pasta, pizza and red wine. Mediterranean-style diets are supported by Diabetes UK and have an extensive evidence base, see page 25. Name Description Cost Contact details Diabetes UK online This provides simple advice about Free https://www.diabetes.org.uk/guide-to- Mediterranean meal choosing Mediterranean-style foods and diabetes/enjoy-food/eating-with-diabetes/meal- plan provides a 7-day menu plan with recipes. plans-/mediterranean Mediterranean-style Diet sheet Free Available at the back of this resource diet Dietary management of type 2 diabetes Page 15 of 40 TVDF resource pack. September 2019. Final v1
4.4 Low fat, healthy eating These diets are recommended for the management of type 2 diabetes and for CVD risk reduction by most authorities, although an energy restriction is required for those who would benefit from weight loss. This strategy has been widely used in research studies and the evidence review is available on page 26. Name Description Cost Contact details NHS online weight A 12-week online plan incorporating Free https://www.nhs.uk/live-well/healthy-weight/start- loss plan dietary advice, physical activity and the-nhs-weight-loss-plan/ behavioural strategies British Heart A booklet including dietary advice, Free https://www.google.com/url?sa=t&rct=j&q=&esrc=s Foundation ‘Facts not physical activity and behavioural support &source=web&cd=1&cad=rja&uact=8&ved=2ahUKE Fads’ for weight loss wiMrpLh1NnjAhXkolwKHcgcBcAQFjAAegQIBBAC&url =https%3A%2F%2Fwww.bhf.org.uk%2F~%2Fmedia% 2Ffiles%2Fpublications%2Fhealthy-eating-and- drinking%2Fm2_facts_not_fads_weightv2.pdf&usg= AOvVaw3m0kZLaDwZcbuWofw1ppyo Diabetes UK online Online 1200-1800 kcal/day, nutrient- Free https://www.diabetes.org.uk/guide-to- energy restricted dense diets that and are high in fruit and diabetes/enjoy-food/eating-with-diabetes/meal- diets vegetables and dietary fibre and low in plans saturated fat. They offer 7-day menu plans with recipes for both meat-eaters and vegetarians Our Path QISMET approved online 12-week weight £90 for 3m https://www.ourpath.co.uk management programme incorporating without tech dietary advice, physical activity and support behavioural support £180 for 3m with tech support Dietary management of type 2 diabetes Page 16 of 40 TVDF resource pack. September 2019. Final v1
Carbs and Cals/World Books and apps. These resources are Books £9.99 https://www.carbsandcals.com Foods designed for those who wish to Apps £4.99 carbohydrate and calorie count. They are not designed for stand-alone use, but are and useful for supporting a specific carbohydrate or energy restriction Dietary management of type 2 diabetes Page 17 of 40 TVDF resource pack. September 2019. Final v1
4.5 Intermittent fasting Intermittent fasting includes restricting energy intake to 500-600 kcal for 2 days per week (often referred to as the 5:2 or Fast diet), alternate day fasting or time-restricted eating which involves leaving a >12-hour window without food each day. There is limited evidence for people with type 2 diabetes, although most studies report that these strategies are as effective as continuous energy restriction, see evidence review on page 27. The greatest issue is that there is an increased risk of hypoglycaemia in people treated by insulin or sulfonylureas, and proactive medication adjustment is required on fasting days, see Appendix 4, page 48. Name Description Cost Contact details The Fast Diet Book by Michael Mosley and Mimi Book available https://thefastdiet.co.uk Spencer. This programme, also known as from Amazon 5:2 includes 5 days of normal eating and 2 ~£6.99 days fasting (500-600kcal) each week. Available as either a book or online programme Carbs and Cals 5:2 Book and app by Chris Cheyette and Yello Book £9.99 https://www.carbsandcals.com Balolia with pictorial food plans and App £4.99 recipes The 2-day diet Book by Michele Harvie and Tony Howell. £12.99 https://www.penguin.co.uk/articles/2019/feb/why- This version of 5:2 involves two the-2-day-diet-works.html consecutive days of low-carb, high-protein eating, and healthy Mediterranean style eating the rest of the week. Dietary management of type 2 diabetes Page 18 of 40 TVDF resource pack. September 2019. Final v1
4.6 Low glycaemic index diets Recent meta-analyses have confirmed that low GI diets have little or no effect on weight loss and only a small (but significant) effect on glycaemic control, see evidence review, page 31 for further details. For this reason, they are no longer recommended as a primary strategy for people with type 2 diabetes, although they may be useful for fine-tuning blood glucose control. Dietary management of type 2 diabetes Page 19 of 40 TVDF resource pack. September 2019. Final v1
Evidence review for resources In order to ensure that people with diabetes are able to make informed choices about personal dietary strategies, the TVDF has formulated an evidence review for a selection of widely available resources. The resources were selected by dietitians working in the Thames Valley and were those that were most frequently mentioned by people with type 2 diabetes during consultations. The evidence has been restricted to studies in people with type 2 diabetes, although where evidence is limited, e.g. intermittent fasting (5:2 diet) findings from the general population have been discussed. In each dietary category, an overview of the evidence-base is provided and each specific resource within a category has then been assessed. A hierarchy of evidence has been used to grade the evidence for each resource based on the methodology adopted by the Scientific Advisory Committee on Nutrition (SACN)3: • Adequate – a meta-analysis was performed on three or more randomised controlled trials. Alternatively, a total of four or more studies were identified in the systematic review and/or the update search; these consistently showed the same outcome although a meta-analysis was not performed. • Moderate – a meta-analysis was performed on three or more randomised controlled trials. Alternatively, three or more randomised controlled trials were identified in the systematic review and/or the update search, which consistently showed the same outcome although a meta-analysis was not performed. • Limited – three to four randomised controlled trials were identified and there was some indication that the results were in the same direction, but no meta-analysis was performed. However, the evidence may also have been considered limited if there were a number of studies, but the biological plausibility was unclear, the methodology was not precise or the exposures were heterogeneous. • Inconsistent – the results from meta-analyses or pooled analyses are conflicting and it is not possible to draw a conclusion. • Insufficient – there are no meta-analyses and
1. Low energy (calorie) diets Evidence grade: Adequate Low energy diets (LED) are defined as providing 800-1200 kcal/day4 and are typically composed of total diet replacement (TDR) using formula foods, a food-based diet or partial replacement (where one or two meals a day are replaced by formula foods). The evidence for both TDR and food-based diets are discussed below. It is important to note that very low energy diets (VLED), defined as providing approximately 600-800 kcal/day, are not currently recommended by NICE4 and have not been further considered here. 1.1 Total diet replacement Evidence grade: Adequate TDR provides the strongest evidence for the efficacy of low energy diets, with evidence of benefit in people with type 2 diabetes5,6. Two recent trials reported weight losses of ~10kg at one-year’s follow-up7,8. In addition, the DiRECT trial has reported diabetes remission rates of 46% at one year and 36% at two-years follow-up following a period of TDR7,9. The authors emphasise that this was a structured, behavioural intervention designed to maintain weight loss over the longer term, and the idea that TDR alone can be used as a quick fix for either weight loss or remission of type 2 diabetes is not supported by current evidence. Only Counterweight Plus (used in DiRECT7) and the Cambridge Plan (used in DROPLET8) have any direct evidence of effect, but there is little reason to suggest that other commercial providers would be inferior. 1.2 Food-based diets Evidence grade: Moderate The evidence for food-based LEDs is weaker than that for TDR, although a recent meta-analysis reports favourable outcomes for 800-1200kcal/day diets in people with type 2 diabetes10. In addition, a small local pilot study of 800-1000kcal/day has demonstrated significant weight loss and improvements in glycaemic control11. 1.2.1 The 8-week blood sugar diet (Online and book) Evidence grade: Insufficient This book is based on the success of the DiRECT trial and suggests that food can be used to replace the TDR stage which provides ~800kcal/day. However, the TDR phase of DiRECT lasted 12-20 weeks, and there are no studies specifically investigating an 8-week period of restriction. Dietary management of type 2 diabetes Page 21 of 40 TVDF resource pack. September 2019. Final v1
In addition, although this book provides tips for maintenance of weight loss, it does not include a structured maintenance programme. 1.2.2 The Fast 800 (online and book) Evidence grade: Insufficient This programme is a combination of 800kcal/day with a 5:2 diet and a weight maintenance plan based on a Mediterranean diet. Although well-written and easy to use (especially the online plan with recipes), there is limited evidence to support intermittent fasting in type 2 diabetes (see section below) and no study has investigated this combination of strategies for efficacy. 1.2.3 Carbs and cals VLED meal plans and recipes Evidence grade: Insufficient This book suggests meal plans and recipes that can be used to provide ~800kcal/day. No recommendations are made about the period of restriction (30-day meal plans are provided) or food reintroduction at the end of the restriction phase. 2. Low carbohydrate diets Evidence grade: Adequate Low carbohydrate (
1.1 NHS online low carb programme Evidence grade: Adequate for low carbohydrate component Although there is evidence of efficacy from low carbohydrate diet studies, only two studies have reported outcomes for online low carbohydrate programmes. Both studies report positive outcomes in terms of improvements in glycaemic control, weight loss and reductions in diabetes medication22,23. However, firm conclusions are limited by the lack of evidence from large randomised controlled trials of online interventions and the fact that of the two studies mentioned above, one study was an audit without a comparator group 22 and the other was a small study (n=25) using a very low carbohydrate ketogenic diet (20-50g carbohydrate/day) as the intervention23. 1.2 Diabetes UK online low carb meal plan Evidence grade: See comments above 1.4 Diet Doctor online programme Evidence grade: Insufficient Despite general evidence that carbohydrate restriction is effective, no head-to-head studies have investigated the three levels of restriction recommended in this programme (Low/keto:
A low carbohydrate, high fat (LCHF) ketogenic diet is recommended here and there is little evidence of efficacy of this strategy in people with type 2 diabetes. Although there is no agreed definition for a low carbohydrate ketogenic diet, it is generally assumed that ketosis occurs at intakes of
1.7 Public Health Collaboration resources Evidence grade: Insufficient The advice published online by the Public Health Collaboration (PHC) states that the carbohydrate restriction for weight loss should be
4. General advice/low fat/healthy eating 4.1 Carbs and Cals counter book/app and Carbs and Cals World Foods Evidence grade: Insufficient for carbohydrate counting, adequate for calorie counting/energy restriction The efficacy of carbohydrate counting on weight loss in people with type 2 diabetes is largely unknown. One small study investigating the effects on glycaemia in people taking insulin reported that it is as effective in reducing HbA1c as a simple algorithm 45. However, although monitoring carbohydrate intake whether by use of exchanges, portions or experience-based estimation remains a key strategy in achieving glycaemic control in people with type 2 diabetes, there are no studies investigating its role in weight loss. Counting calories and energy restriction are effective for weight loss46. 4.2 NHS online Weight loss plan Evidence grade: Adequate A 12-week online energy-restricted diet and exercise programme including behavioural strategies. This combination of strategies is effective for weight loss in people with type 2 diabetes46. 4.3 Diabetes UK online energy-restricted diets Evidence grade: Adequate Diabetes UK offer online 1200 and 1500kcal/day diets for men and women and include vegetarian options. In addition the web-site offers behavioural tips for weight loss and this approach is effective for people with type 2 diabetes45. 4.4 OurPath online weight loss programme Evidence grade: Adequate A 12-week online diet and exercise programme endorsed by the NHS. Individuals are provided with a handbook, smart scales and optional activity tracker and are supported by a personal health coach. Behavioural strategies are integral to the programme. After the 12 week intervention period, a weight loss maintenance programme is offered. This combination of strategies is effective for weight loss in people with type 2 diabetes46. 4.3 BHF Facts not fads Evidence grade: Adequate Dietary management of type 2 diabetes Page 26 of 40 TVDF resource pack. September 2019. Final v1
The BHF guide is based on the concept of healthy eating and the Eatwell Guide. It includes guidance for energy restriction and includes behavioural strategies. This combination of strategies is effective for weight loss in people with type 2 diabetes46. 4.3 MyFitnessPal app Evidence grade: Insufficient It is widely acknowledged that self-monitoring supports weight loss in the general population47,48, although there is little evidence for those with type 2 diabetes. Electronic devices such as MyFitnessPal are a means of self-monitoring, although it has been reported that it tends to underestimate intake49,50. A study specifically investigating its use for weight loss in primary care reported that it neither supported weight loss nor had any effect compared to usual care51. 5. Intermittent fasting (IF) Evidence grade: Limited Intermittent fasting has been sub-divided into restricted intake (usually 500-600kcal/day) on 2 days each week (often called the 5:2 or Fast diet), alternate day fasting where intake is restricted on alternate days or time-restricted eating where meals are typically restricted to an 8-hour window52. A recent review has reported that IF is as effective as continuous energy restriction (CER) for weight loss in the general population, although the authors state in their conclusion that ‘reaching a firm conclusion on the relative merits of IF is not possible without further studies with appropriate controls’53. One randomised controlled trial in people with type 2 diabetes reported no difference between IF and CER at one and two-year’s follow-up54,55, although both strategies were effective for weight loss and improving glycaemic control. 5.1 The Fast Diet Evidence grade: Limited See above comments 5.2 Carbs and Cals 5:2 diet photos Evidence grade: Limited See above comments Dietary management of type 2 diabetes Page 27 of 40 TVDF resource pack. September 2019. Final v1
5.3 The 2-day diet Evidence grade: Limited See above comments 6. Low GI diets Evidence grade: Inconsistent Low GI diets have been recommended as a first-line strategy for managing type 2 diabetes, although they have no significant effect on weight loss56,57. In the past, low Gl diets have been reported to lower HbA1c by 4-6mmol/mol (0.4–0.5%), although these results may be confounded by differences in fibre content and effects of body weight between low and high GI diets. However, more recent meta-analyses have reported more modest effects of 2- 3mmol/mol (0.2-0.3%)58,59 and low GI diets are no longer recommended by Diabetes UK for weight loss although they may be useful for fine-tuning glycaemic control1. References 1. Diabetes UK. Evidence-based nutrition guidelines for the prevention and management of diabetes. March 2018. Available at: https://diabetes-resources-production.s3.eu- west-1.amazonaws.com/resources-s3/2018-03/1373_Nutrition%20guidelines_0.pdf 2. National Institute for Health and Care Excellence. Type 2 diabetes in adults: management [NG 28]. London, NICE;2015. 3. Scientific Advisory Committee on Nutrition and Health. Carbohydrates and health. SACN. 2015; London: TSO. 4. National Institute for Health and Care Excellence. Obesity: Identification, assessment and management of overweight and obesity in children, young people and adults (CG189). NICE, London; 2014 5. Leslie WS, Taylor R, Harris L, Lean ME. Weight losses with low-energy formula diets in obese patients with and without type 2 diabetes: systematic review and meta-analysis. Int J Obes (Lond). 2017;41:96-101. 6. Sellahewa L, Khan C, Lakkunarajah S, Idris I. A Systematic Review of Evidence on the Use of Very Low Calorie Diets in People with Diabetes. Curr Diabetes Rev. 2017;13(1):35-46. 7. Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, Rodrigues AM, Rehackova L, Adamson AJ, Sniehotta FF, Mathers JC, Ross HM, McIlvenna Y, Stefanetti R, Trenell M, Welsh P, Kean S, Ford I, McConnachie A, Sattar N, Taylor R. Primary care-led weight management for remission of type 2 diabetes: (DiRECT): an open-label, cluster-randomised trial. Lancet. 2018;391:541-551. 8. Astbury NM, Aveyard P, Nickless A, Hood K, Corfield K, Lowe R, Jebb SA. Doctor Referral of Overweight People to Low Energy total diet replacement Treatment (DROPLET): pragmatic randomised controlled trial. BMJ. 2018;362:k3760. Dietary management of type 2 diabetes Page 28 of 40 TVDF resource pack. September 2019. Final v1
9. Lean MEJ, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, Rodrigues AM, Rehackova L, Adamson AJ, Sniehotta FF, Mathers JC, Ross HM, McIlvenna Y, Welsh P, Kean S, Ford I, McConnachie A, Messow CM, Sattar N, Taylor R. Durability of a primary care-led weight- management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes Endocrinol. 2019;7(5):344-355. 10. Kloecker DE, Zaccardi F, Baldry E, Davies MJ, Khunti K, Webb DR. Efficacy of low- and very-low-energy diets in people with type 2 diabetes mellitus: A systematic review and meta-analysis of interventional studies. Diabetes Obes Metab. 2019;21(7):1695-1705. 11. Morris E, Aveyard P, Dyson P, Noreik M, Bailey C, Fox R, Hoffman K, Tan GD, Jebb SA. Dietary Approaches to the Management Of type 2 Diabetes (DIAMOND): protocol for a randomised feasibility trial. BMJ Open. 2019;9(1):e026460. 12. McArdle PD, Greenfield SM, Rilstone SK, Narendran P, Haque MS, Gill PS. Carbohydrate restriction for glycaemic control in Type 2 diabetes: a systematic review and meta-analysis. Diabet Med. 2019;36(3):335-348. 13. Sainsbury E, Kizirian NV, Partridge,SR, Gill T, Colagiuri S, Gibson AA. Effect of dietary carbohydrate restriction on glycemic control in adults with diabetes: A systematic review and meta‐analysis. Diabetes Res Clin Pract. 2018;139:239– 252. 14. Schwingshackl L, Chaimani A, Hoffmann G, Schwedhelm C, Boeing H. A network meta‐ analysis on the comparative efficacy of different dietary approaches on glycaemic control in patients with type 2 diabetes mellitus. Eur J Epidemiol. 2018;33:157– 170. 15. van Zuuren EJ, Fedorowicz Z, Kuijpers T, Pijl H. Effects of low-carbohydrate- compared with low-fat-diet interventions on metabolic control in people with type 2 diabetes: a systematic review including GRADE assessments. Am J Clin Nutr. 2018;108(2):300-331. 16. Korsmo-Haugen HK, Brurberg KG, Mann J, Aas AM. Carbohydrate quantity in the dietary management of type 2 diabetes - a systematic review and meta-analysis. Diabetes Obes Metab. 2018. doi: 10.1111/dom.13499. 17. Huntriss R, Campbell M, Bedwell C. The interpretation and effect of a low‐carbohydrate diet in the management of type 2 diabetes: a systematic review and meta‐analysis of randomised controlled trials. Eur J Clin Nutr 2018; 72: 311– 325. 18. Snorgaard O, Poulsen GM, Andersen HK, Astrup A. Systematic review and meta‐analysis of dietary carbohydrate restriction in patients with type 2 diabetes. BMJ Open Diabetes Res Care. 2017;5:e000354. 19. Meng Y, Bai H, Wang S, Li Z, Wang Q, Chen L. Efficacy of low carbohydrate diet for type 2 diabetes mellitus management: A systematic review and meta‐analysis of randomized controlled trials. Diabetes Res Clin Pract. 2017;131:124– 131. 20. Fan Y, Di H, Chen G, Mao X, Liu C. Effects of low carbohydrate diets in individuals with type 2 diabetes: systematic review and meta-analysis. Int J Clin Exp Med. 2016; 9(6): 11166-11174. 21. Naude CE, Schoonees A, Senekal M, Young T, Garner P, Volmink J. Low Carbohydrate versus Isoenergetic Balanced Diets for Reducing Weight and Cardiovascular Risk: A Systematic Review and Meta-Analysis. PLoS ONE. 2014;9(7):e100652. 22. Saslow LR, Summers C, Aikens JE, Unwin DJ. Outcomes of a Digitally Delivered Low- Carbohydrate Type 2 Diabetes Self-Management Program: 1-Year Results of a Single- Arm Longitudinal Study. JMIR Diabetes. 2018;3(3):e12. 23. Saslow LR, Mason AE, Kim S, Goldman V, Ploutz-Snyder R, Bayandorian H, Daubenmier J, Hecht FM, Moskowitz JT. An Online Intervention Comparing a Very Low- Dietary management of type 2 diabetes Page 29 of 40 TVDF resource pack. September 2019. Final v1
Carbohydrate Ketogenic Diet and Lifestyle Recommendations Versus a Plate Method Diet in Overweight Individuals With Type 2 Diabetes: A Randomized Controlled Trial. J Med Internet Res. 2017;19(2):e36. 24. Mayer SB, Jeffreys AS, Olsen MK, McDuffie JR, Feinglos MN, Yancy WS Jr. Two diets with different haemoglobin A1c and antiglycaemic medication effects despite similar weight loss in type 2 diabetes. Diabetes Obes Metab. 2014;16(1):90-3. 25. Westman EC, Yancy WS Jr, Mavropoulos JC, Marquart M, McDuffie JR. The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus. Nutr Metab (Lond). 2008;5:36. 26. Davis NJ, Tomuta N, Schechter C, Isasi CR, Segal-Isaacson CJ, Stein D, Zonszein J, Wylie- Rosett J. Comparative study of the effects of a 1-year dietary intervention of a low- carbohydrate diet versus a low-fat diet on weight and glycemic control in type 2 diabetes. Diabetes Care. 2009;32(7):1147-52. 27. Dyson PA, Beatty S, Matthews DR. A low carbohydrate diet is more effective for reducing body weight than healthy eating in both diabetic and non-diabetic subjects. Diabetic Med. 2007;24(12):1430-1435. 28. Goday A, Bellido D, Sajoux I, Crujeiras AB, Burguera B, García-Luna PP, Oleaga A, Moreno B, Casanueva FF. Short-term safety, tolerability and efficacy of a very low-calorie- ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus. Nutr Diabetes. 2016;6(9):e230. 29. Goldstein T, Kark JD, Berry EM, Adler B, Ziv E, Raz I. The effect of a low carbohydrate energy-unrestricted diet on weight loss in obese type 2 diabetes patients – A randomized controlled trial. Clin Nutr. 2011;6(4):e178-86. 30. Gumbiner B, Low CC, Reaven PD. Effects of a monounsaturated fatty acid-enriched hypocaloric diet on cardiovascular risk factors in obese patients with type 2 diabetes. Diabetes Care. 1998;21(1):9-15. 31. Saslow LR, Daubenmier JJ, Moskowitz JT, Kim S, Murphy EJ, Phinney SD, Ploutz-Snyder R, Goldman V, Cox RM, Mason AE, Moran P, Hecht FM. Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very low-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes. Nutr Diabetes. 2017;7(12):304. 32. Tay J, Luscombe-Marsh ND, Thompson CH, Noakes M, Buckley JD, Wittert GA, Yancy WS Jr, Brinkworth GD. A very low-carbohydrate, low-saturated fat diet for type 2 diabetes management: a randomized trial. Diabetes Care. 2014;37(11):2909-18. 33. Daly ME, Paisey R, Paisey R, Millward BA, Eccles C, Williams K, Hammersley S, MacLeod KM, Gale TJ. Short-term effects of severe dietary carbohydrate-restriction advice in Type 2 diabetes--a randomized controlled trial. Diabet Med. 2006;23(1):15-20. 34. Guldbrand H, Dizdar B, Bunjaku B, Lindström T, Bachrach-Lindström M, Fredrikson M, Ostgren CJ, Nystrom FH. In type 2 diabetes, randomisation to advice to follow a low- carbohydrate diet transiently improves glycaemic control compared with advice to follow a low-fat diet producing a similar weight loss. Diabetologia. 2012;55(8):2118-27. 35. Jonasson L, Guldbrand H, Lundberg AK, Nystrom FH. Advice to follow a low- carbohydrate diet has a favourable impact on low-grade inflammation in type 2 diabetes compared with advice to follow a low-fat diet. Ann Med. 2014;46(3):182-7. 36. van Wyk HJ, Davis RE, Davies JS. A critical review of low-carbohydrate diets in people with Type 2 diabetes. Diabet Med. 2016;33(2):148-57. Dietary management of type 2 diabetes Page 30 of 40 TVDF resource pack. September 2019. Final v1
37. Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frassetto L, Gower BA, McFarlane SI, Nielsen JV, Krarup T, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, Dahlqvist A, Sundberg R, Childers A, Morrison K, Manninen AH, Dashti HM, Wood RJ, Wortman J, Worm N. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition. 2015;31(1):1-13. 38. Scientific Advisory Committee on Nutrition and Health. Saturated fat and health. SACN. 2019; London: TSO. 39. Papamichou D, Panagiotakos DB, Itsiopoulos C. Dietary patterns and management of type 2 diabetes: A systematic review of randomised clinical trials. Nutr Metab Cardiovasc Dis. 2019. pii: S0939-4753(19)30054-7. 40. Esposito K, Maiorino MI, Bellastella G, Chiodini P, Panagiotakos D, Giugliano D. A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses. BMJ Open. 2015;5(8):e008222. 41. Koloverou E, Esposito K, Giugliano D, Panagiotakos D. The effect of Mediterranean diet on the development of type 2 diabetes mellitus: a meta-analysis of 10 prospective studies and 136,846 participants. Metabolism.2014;63(7):903-911. 42. Esposito K, Maiorino MI, Petrizzo M, Bellastella G, Giugliano D. The effects of a Mediterranean diet on the need for diabetes drugs and remission of newly diagnosed type 2 diabetes: follow-up of a randomized trial. Diabetes Care. 2014;37(7):1824-1830. 43. Becerra-Tomás N, Blanco Mejía S, Viguiliouk E, Khan T, Kendall CWC, Kahleova H, Rahelić D, Sievenpiper JL, Salas-Salvadó J. Mediterranean diet, cardiovascular disease and mortality in diabetes: A systematic review and meta-analysis of prospective cohort studies and randomized clinical trials. Crit Rev Food Sci Nutr. 2019:1-21. 44. Elhayany A, Lustman A, Abel R, Attal-Singer J, Vinker S. A low carbohydrate Mediterranean diet improves cardiovascular risk factors and diabetes control among overweight patients with type 2 diabetes mellitus: a 1-year prospective randomized intervention study. Diabetes Obes Metab. 2010;12(3):204-9. 45. Bergenstal RM, Johnson M, Powers MA, Wynne A, Vlajnic A, Hollander P, Rendell M. Adjust to target in type 2 diabetes: comparison of a simple algorithm with carbohydrate counting for adjustment of mealtime insulin glulisine. Diabetes Care. 2008;31(7):1305- 10. 46. Franz MJ, Boucher JL, Rutten-Ramos S, VanWormer JJ. Lifestyle weight-loss intervention outcomes in overweight and obese adults with type 2 diabetes: a systematic review and meta-analysis of randomized clinical trials. J Acad Nutr Diet. 2015;115(9):1447-63. 47. Hartmann-Boyce J, Boylan AM, Jebb SA, Aveyard P. Experiences of Self-Monitoring in Self-Directed Weight Loss and Weight Loss Maintenance: Systematic Review of Qualitative Studies. Qual Health Res. 2018:1049732318784815. 48. Burke LE, Wang J, Sevick MA. Self-monitoring in weight loss: a systematic review of the literature. J Am Diet Assoc. 2011;111(1):92-102. 49. Chen J, Berkman W, Bardouh M, Ng CYK, Allman-Farinelli M. The use of a food logging app in the naturalistic setting fails to provide accurate measurements of nutrients and poses usability challenges. Nutrition. 2019;57:208-216. 50. Teixeira V, Voci SM, Mendes-Netto RS, da Silva DG. The relative validity of a food record using the smartphone application MyFitnessPal. Nutr Diet. 2018;75(2):219-225. Dietary management of type 2 diabetes Page 31 of 40 TVDF resource pack. September 2019. Final v1
51. Laing BY, Mangione CM, Tseng CH, Leng M, Vaisberg E, Mahida M, Bholat M, Glazier E, Morisky DE, Bell DS. Effectiveness of a smartphone application for weight loss compared with usual care in overweight primary care patients: a randomized, controlled trial. Ann Intern Med. 2014;161(10 Suppl):S5-12. 52. Patterson RE, Sears DD. Metabolic effects of intermittent fasting. Annu Rev Nutr. 2017;37:371-393. 53. Templeman I, Gonzalez JT, Thompson D, Betts JA. The role of intermittent fasting and meal timing in weight management and metabolic health. Proc Nutr Soc. 2019:1-12. 54. Carter S, Clifton PM, Keogh JB. Effect of Intermittent Compared With Continuous Energy Restricted Diet on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Noninferiority Trial. JAMA Netw Open. 2018;1(3):e180756. 55. Carter S, Clifton PM, Keogh JB. The effect of intermittent compared with continuous energy restriction on glycaemic control in patients with type 2 diabetes: 24-month follow-up of a randomised noninferiority trial. Diabetes Res Clin Pract. 2019 Mar 19;151:11-19. 56. Marsh K, Barclay A, Colagiuri S, Brand-Miller J. Glycemic index and glycemic load of carbohydrates in the diabetes diet. Curr Diab Rep. 2011;11(2):120-7. 57. Ajala O, English P, Pinkney J. Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes. Am J Clin Nutr. 2013;97(3):505-16. 58. Ojo O, Ojo OO, Adebowale F, Wang XH. The Effect of Dietary Glycaemic Index on Glycaemia in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2018;10(3). pii: E373. 59. Wang Q, Xia W, Zhao Z, Zhang H. Effects comparison between low glycemic index diets and high glycemic index diets on HbA1c and fructosamine for patients with diabetes: A systematic review and meta-analysis. Prim Care Diabetes. 2015;9(5):362-9. Dietary management of type 2 diabetes Page 32 of 40 TVDF resource pack. September 2019. Final v1
Appendix 1 Structured education programmes Berkshire Area Programme name Description of programme Contact details Berkshire East DEAL* The course is 2 x 3 hours sessions. Referral via DXS to Session 1: Bks-tr.DiabetesCentre@nhs.net • What is Type 2 Diabetes and what it means to you and your family or send completed referral form by post to: • Management of diabetes and the medications used • How to monitor your blood glucose levels and Bookings Co-Ordinators what the different blood results mean Diabetes Centre • Understanding the long term complications, King Edward VII Hospital with advice on prevention and treatment St. Leonard’s Road • Looking after your health and what health checks you are entitled to Windsor • Employment and driving advice Berkshire SL4 3DP Session 2: • What foods affect your diabetes • What and how much to eat • How to read food labels and what to look out for • Advice on eating out and celebrations • How to change food behaviours • How to manage your weight • Goal planning Dietary management of type 2 diabetes Page 33 of 40 TVDF resource pack. September 2019. Final v1
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