COVID-19 VACCINATION STRATEGIES - A scoping review of international approaches COVID-19 POLICY SERIES GLOBAL HEALTH GOVERNANCE PROGRAMME - global ...
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COVID-19 VACCINATION STRATEGIES A scoping review of international approaches COVID-19 POLICY SERIES GLOBAL HEALTH GOVERNANCE PROGRAMME 21 November 2020
Global Health Governance Programme 21 November 2020 Contributors: Gabrielle Geonnotti Kavya Anchuri Jay Patel Maartje Kletter Genevie Fernandes 2
Global Health Governance Programme 21 November 2020 BACKGROUND: We conducted a scoping review of grey literature reports, peer-reviewed articles and news media reports to summarise the COVID-19 related vaccination strategies of 15 countries across North America, Europe and East Asia. In our searches, we tried to locate information for four broad areas i.e. (i) procurement, (ii) governance in terms of decision-making bodies and plans, (iii) vaccine distribution and administration strategies, and (iv) public attitudes and efforts for public information and communication. We have listed the key findings under each area below. Please see table 1 for a detailed summary of each country case based on the available information. SUMMARY: Vaccine procurement: ▪ Countries have undertaken four predominant routes to secure vaccine doses for their populations: o First, all the countries except for the US have joined the COVAX Facility coordinated by Gavi, the Vaccine Alliance, the Coalition for Epidemic Preparedness Innovations (CEPI) and the WHO. European countries including Austria, France, Germany, Greece, Italy, and Spain have joined the COVAX Facility as ‘Team Europe’ which is the European Commission on behalf of the 27 European Union member states as well as Norway and Iceland, negotiating for vaccine doses proportional to each country’s population. o Second, apart from the COVAX agreement, countries have also struck separate deals with the leading pharmaceutical companies developing the COVID-10 vaccine viz. Pfizer and BioNTech, AstraZeneca, Moderna, Johnson & Johnson, Valneva, and Sanofi and GlaxoSmithKline, for securing millions of vaccine doses for advance financial commitments. The first COVID-19 vaccines will require doses 3-4 weeks apart, which explains the increased number of doses being secured by some countries. However, Oxfami has warned that such dealmaking by richer countries representing just 13 per cent of the world’s population has already bought more than half of the leading vaccine candidates’ promised doses. Canada for instance has a population of 38 million, but has secured close to 358 million doses; Japan has 126 million citizens and has brokered deals securing 521 million doses. Contrastingly, South Korea intends to vaccinate 70% of its 51 million population to attain herd immunity, and accordingly has secured 60 million doses. o Third, countries are also funding local vaccine candidates, currently in the early stages of development and testing. o Fourth, countries like Mexico for instance, have agreed to host human trials of Covid-19 vaccines to strengthen relations with pharmaceutical companies in case limited production capacity leads to a battle for doses. ▪ Phase 3 trials are being conducted in the United Kingdom (UK) (AstraZeneca and Oxford University and Novavax) and the United States of America (USA) (Moderna and Johnson & Johnson). Additionally, a Phase 3 trial is being conducted in Canada with a focus on prevention of COVID-19 in cancer patients. Further, preparations for the start of a Phase 3 trial are undertaken in Austria. Phase 1 and/or Phase 2 trials are being conducted in Canada (n=3), Taiwan (n=2), South Korea (n=1), Singapore (n=1), Japan (n=1), Mexico (n=1), Austria (n=1) and Italy (n=1). Finally, pre-clinical vaccines were developed in Germany (n=2) South Korea (n=2), Hong Kong (n=1) and Spain (n=4). ▪ Germany added an additional 100 million euros to COVAX aimed at providing vaccine access in Low- and Middle Income Countries (LMIC). The UK provided £500 million aimed at providing access to vaccines in LMIC whereas Canada invested 440 million in COVAX of which half will go to vaccines for Canadians specifically. ▪ Several countries have invested in improving infrastructure in order to manufacture sufficient number of effective and approved vaccines. The UK, Canada and the US have invested to advance domestic manufacturing capabilities in order to have sufficient vaccine available. Further, in the US, distributors of vaccine components were identified and invested in. Singapore intends to ramp up to production of vaccine when they become available. Japan has obtained a licence to manufacture as well as commercialise the Novavax vaccine. Governance: 3
Global Health Governance Programme 21 November 2020 ▪ For most of the countries (n=13), we found information about established national-level taskforces or committees overseeing the vaccine procurement and vaccination plans. Countries including UK, US and Canada have set up their vaccine taskforce as a public-private partnership embedded within government departments. ▪ We found detailed vaccination strategies released by the US, Germany, and France, outlining the complete process of distribution, public communication, administration, and monitoring of vaccination. Germany has laid out a national strategy for three phases as the availability of doses, experience with the vaccine increases. Further, the health ministers of the 16 federal states of Germany have also drawn up vaccination plans including delivery and administration of vaccines. Vaccine distribution and administration: ▪ All countries have identified priority populations that will receive vaccination in the first phase when vaccines get approved and become available, followed by general population in the next phases. ▪ Health and social care workers, older adults (>60), and those with chronic health conditions were commonly identified by all countries as being at high-risk and priority population groups for vaccinations. Additionally, Canada’s guidelines for priority populations also included those who live/ work in settings where physical distancing is challenging, healthcare infrastructure is lacking, and/ or where infection could have disproportionate consequences compared to the general population (e.g. Indigenous reservations), while US guidelines also included people with limited access to routine vaccination services. ▪ In terms of vaccine delivery, the German government will deliver vaccines to 60 delivery locations (wholesalers, pharmacies) in all federal states. Health ministers of the 16 federal states have drawn up plans to create one to two centers per administrative district — totaling hundreds of centers — as well as employing mobile vaccination teams. Similarly, Austria will also employ mobile vaccination teams. ▪ With respect to vaccination settings, US guidelines have listed healthcare provider offices and other outpatient clinics, public health clinics, chain and independent pharmacies, school-based health centers, worksites and other occupational health clinics, hospitals, temporary or off-site vaccination clinics and mobile vaccinators. In France, target populations will be vaccinated as close as possible to the people concerned – i.e. “in the field” Outpatient vaccination in doctors’ offices is also expected. Italy’s vaccine task force is reportedly planning where injections will be carried out: as well as at existing vaccination clinics and doctors' offices, the health service could set up large-scale, temporary centres in the same way it has created drive-through coronavirus testing sites. ▪ In Germany digital appointments are being planned, real time surveys and applications for monitoring safety and effectiveness also in pipeline. In Japan, those wishing for a vaccine will be inoculated for free at health care facilities by submitting special coupons to be distributed by local municipalities; they will also receive a certificate upon vaccination. Public attitudes and communication: ▪ In a global surveyii with 13,426 people in 19 countries, around 71% of participants reported that they would be very or somewhat likely to take a COVID-19 vaccine, and 61% reported that they would accept their employer’s recommendation to do so. Differences in acceptance rates ranged from almost 90% (in China) to less than 55% (in Russia). Respondents reporting higher levels of trust in information from government sources were more likely to accept a vaccine and take their employer’s advice to do so. ▪ Surveys conducted in Germany, France, Italy, Spain, and the US found that one-third of participants had doubts about a new vaccine and were not willing to receive it. While surveys in South Korea, Taiwan and Singapore revealed high levels willingness to accept a vaccine and high levels of trust in the government. ▪ These findings raise the issue of public hesitancy and skepticism over a new vaccine that needs to be urgently addressed through rapid, clear, transparent and multipronged communication from government authorities. 4
Global Health Governance Programme 21 November 2020 COUNTRY DEVELOPMENT AND PROCUREMENT GOVERNANCE STRATEGY PUBLIC ATTITUDES AND (Population) (Taskforce, Plans) (Doses, Target groups, Timelines, COMMUNICATION Delivery) UK The UK Government has secured access to 355 Two government bodies advising and JCVI has released a provisional list for Vaccine Task Force has (67 million) million doses of six vaccines across four different playing a lead role in decision-making: vaccine prioritisation which indicates that launched a series of podcasts formats: adenoviral vectors, mRNA, adjuvanted (i) Joint Committee of Vaccine and older adults living in care homes, their on Amazon and Spotify with proteins, and whole inactivated viral vaccines, Immunisation (JCVI) care workers, all adults over 80, all health experts discussing all key developed by AstraZeneca and Oxford (100 (ii) Vaccine Taskforce (VT) and social care workers, should rank first aspects of vaccine million doses), BioNTech and Pfizer (40 million to receive the vaccine. After this, risk (and development to inform the doses), Janssen (30 million doses), Moderna (5 JCVI is an existing government body. The priority for receiving the vaccine) is public about what to expect viii million doses), GSK/ Sanofi (60 million), Valneva Vaccine Taskforce, a public-private stratified by age and presence of pre- from COVID-19 vaccines. iii vi (60 million). iv partnership, has been recently set up in existing chronic disease. May 2020 by Sir Patrick Vallance. It is v embedded in the Department for Business, UK has pledged £500 million to COVAX. Kate Bingham, head of the UK Energy and Industrial Energy, and is Government’s Vaccine Taskforce, UK also has an agreement with AstraZeneca to responsible for identifying and securing indicated in early October 2020 that less neutralising antibody cocktail as a prophylactic access to effective and safe vaccines, than half of the UK population will receive treatment once clinical trials are completed and supporting clinical studies and funding the coronavirus vaccine—only the most “at manufacturing of vaccines. vii it is approved by regulators, for those who risk”. iv cannot receive a vaccine. Germany Germany has 2 vaccine candidates in pre-clinical In Germany, the Standing Committee on Phase 1 will inoculate high-risk groups and A World Economic Forum ix (83 million) development Vaccination in the Robert Koch Institute populations at higher risk of exposure; survey, however, found that develops national recommendations for phase 2 will open vaccination up to the 69% of respondents in xii xv Germany has joined the COVAX Facility as a the use of licensed vaccines. general population. Germany would be willing to member of “Team Europe”, on behalf of the 27 get a vaccine for COVID-19, if xviii EU members states as well as Norway and The Paul-Ehrlich-Institut, the national Vaccines will be delivered by the German available. Iceland.x Team Europe has secured doses from regulatory authority for vaccines, is government to 60 delivery locations Oxford University and AstraZeneca (300 million), responsible for the release of vaccine (wholesalers, pharmacies) in all federal xiii xvi Sanofi and GlaxoSmithKline (300 million), batches in Germany. states. Health ministers of the 16 CureVac candidate (225 million), BioNTech and federal states have drawn up plans to Pfizer (200 million), Johnson & Johnson Germany has a vaccination strategy in create one to two centers subsidiary (200 million). The bloc is also in talks xiv place, which outlines 3 phases: per administrative district — totaling with Moderna about a potential deal for an initial 1. Targeted, centralised inoculation hundreds of centers — as well as 80 million doses. Germany will receive 18% of 2. Advanced, centralised inoculation employing mobile vaccination teams. doses secured by this bloc. 3. Width, decentralized routine Digital appointments are being planned, inoculation real time surveys and applications for Germany has committed an additional 100 monitoring safety and effectiveness also xi xviixv million euro to the COVAX AMC. in pipeline. 5
Global Health Governance Programme 21 November 2020 COUNTRY DEVELOPMENT AND PROCUREMENT GOVERNANCE STRATEGY PUBLIC ATTITUDES AND (Population) (Taskforce, Plans) (Doses, Target groups, Timelines, COMMUNICATION Delivery) France France has joined the COVAX Facility as a In France, COVID-19 vaccine policy is being France has outlined conditions to be taken In their strategy document, (67 million) member of “Team Europe”, and will secure doses shaped by two key advisory bodies into account for prioritising populations, French health leaders state in proportion to its population. including: such as duration of protection to COVID- that their strategy hinges on xxii 19 and amounts of vaccine available. their ability to promote the In June, Italy, Germany, France and the 1. le Conseil scientifique With these in mind, they have identified vaccine, support the people Netherlands agreed to pay AstraZeneca 750 2. le Comité analyse, recherche et the following priority populations: to receive it, and promote xxv million euros for 300 million doses (with the expertise (CARE) good adherence, also option to buy an additional 100 million) of the First priority stating that vaccine vaccine they are developing with Oxford CARE has published draft guidelines, which ▪ Those at risk due to potential reluctance has been xix University details who will qualify for the vaccination occupational exposure documented in France and first, and highlights people due to their job, ▪ People aged ≥ 65 years or those at authorities cannot take this In October, France called for 25,000 adult risk category, age, or the presence of any risk due to their health for granted when preparing xxi volunteers on Thursday to enrol in a series of chronic illnesses. ▪ People living in precarious situations their campaign. large-scale clinical trials aimed at evaluating the (e.g. homeless) safety and efficacy of several COVID-19 vaccine The number of vaccinations that will be Second priority The three main difficulties xxvi candidates. France’s public research body ordered is still unknown, but it is expected ▪ Departments and overseas regions, if they foresee are : (i) Doubts Inserm, which is in charge of the project, did not to have tens of millions of doses there is a risk of a shortage of about the effectiveness and name the vaccines that would be assessed and (potentially of 2-5 different products) resuscitation safety of some (or all) said it was currently holding discussions with available between the last trimester of ▪ People living in closed facilities (e.g. vaccines, (ii) Controversies on drugmakers, adding it would pick the “most 2020 and the first trimester of 2021, which prisons) public strategies or promising” candidates for the trials. xx could be deployed in case of a second wave ▪ Those with strategic jobs (e.g. police) pharmaceutical products, (iii) of Covid-19. The COVID-19 vaccine Target populations will be vaccinated as specifically might raise a close as possible to the people concerned number of uncertainties. xxiii – i.e. “in the field” Outpatient vaccination in doctors’ offices is also expected. France anticipates training those giving the vaccinations and expects that this workforce will consist of doctors, nurses, and pharmacists, as well as workers from occupational medicine, xxiv hospitals, and the medico-social world COUNTRY DEVELOPMENT AND PROCUREMENT GOVERNANCE STRATEGY PUBLIC ATTITUDES AND (Population) (Taskforce, Plans) (Doses, Target groups, Timelines, COMMUNICATION Delivery) 6
Global Health Governance Programme 21 November 2020 Italy Italy has joined the COVAX Facility as a member A task force of 15 experts has been working Leaders from the Italian Ministry of health The Italian population has a (60 million) of “Team Europe”, and will secure doses in on Italy's immunisation strategy since have said that priority groups, such as history of vaccine skepticism. proportion to its population. Italy will receive November 4th, particularly examining ways healthcare workers, the elderly, and those In 2018, their lawmakers 13.5% of the secured doses that entitles the to distribute the various possible vaccines, with conditions that put them at risk amended a law requiring xxx country to around 165 million at least of all the including different ones at the same time, should get the vaccine first parents to vaccinate their doses secured by the EU so far, for its population with one of the major challenges being children before sending them of 60.2 million people. The government expects how to store vaccines such as Pfizer's that The Italian government has decided to to school; this law introduced its first round of vaccinations to deliver 3.4 need to be kept at temperatures as low as - coordinate its vaccination plan nationally in 2017 that was introduced xxvii xxix million shots to 1.7 million people. 80 degrees C. instead of leaving it up to regional after a measles outbreak.xxxi authorities, who are usually responsible xxxii In June, Italy, Germany, France and the for local healthcare. Netherlands agreed to pay AstraZeneca 750 A study surveyed a random million euros for 300 million doses (with the sample of Italian citizens The task force is reportedly planning during the early days of the option to buy an additional 100 million) of the where injections will be carried out: as pandemic in Italy (n=968) and vaccine they are developing with Oxford well as at existing vaccination clinics and then surveyed a second University. doctors' offices, the health service could random sample of citizens set up large-scale, temporary centres in (n=1004) during the early Italy also has a local vaccine candidate, ReiThera, the same way it has created drive-through days of Italy’s reopening on which began a Phase 1 clinical trial of their xxviii coronavirus testing sites. their willingness to receive a vaccine candidate GRAd-COV2 in August xxxiii vaccine for COVID-19. Regional authorities have been asked to 59% of the respondents in identify suitable storage facilities as well phase 2 reported a as sites that could potentially immunise willingness to receive a xxvii some 2,000 people within 15 days. vaccine. Willingness to vaccinate was positively correlated with trust in scientific research as well as attitude towards vaccine’s efficacy. Greece Greece has joined the COVAX Facility as a As of 1 November 2020 the Greek Health Greece plans to set up more than 1,000 xxxvi (10 million) member of “Team Europe”, and will secure doses Minister has stated that together with the vaccination centres. in proportion to its population. Greece’s National Vaccine Committee they are government has committed an additional 1.5 working on their COVID-19 vaccination xxxiv xxxv million euro to the COVAX AMC plan. COUNTRY DEVELOPMENT AND PROCUREMENT GOVERNANCE STRATEGY PUBLIC ATTITUDES AND (Population) (Taskforce, Plans) (Doses, Target groups, Timelines, COMMUNICATION Delivery) 7
Global Health Governance Programme 21 November 2020 Spain Spain has joined the COVAX Facility as a member A working group has been coordinating Regarding who will qualify to get In August, according to a (47 million) of “Team Europe”, and will secure doses in with central and regional authorities on a immunized first, Spanish Health Minister national survey of 1033 xliii proportion to its population. vaccination plan for the country. has said that while the working group has participants conducted by the to determine these parameters, the Carlos III Health Institute, 30% There are 4 pre-clinical vaccine candidates being logical thing would be for the elderly and of respondents expressed xxxvii .xliv developed in Spain healthcare workers to be the first. doubts about whether they would be vaccinated against xliv Spain has been chosen as the manufacturing site the coronavirus. for two vaccines: (i) Novavax, an American pharma company, has selected Spanish biopharma group Zendal to produce its vaccine xxxviii (ii) Biofabi (whose parent company is Zendal) will reserve manufacturing capacity for CEPI- designated COVID-19 vaccines between Nov 2020-May 2022; the estimated production is xxxix 500 million doses (iii) Moderna has tapped the Spanish Pharma Industrial Services to produce the vials (fill and seal) of their vaccine to be commercialised outside the USxl xli xlii Austria Austria has joined the COVAX Facility as a Austria is currently setting up a national The Ministry of Health is prioritising (8.8 million) member of “Team Europe”, and will secure doses vaccination strategy in coordination with people who are at the greatest “personal in proportion to its population. the European Union. or systemic risk” for the first dose of the vaccine. Health workers and people with Three Austrian companies working on vaccine serious medical conditions that make candidates including (i) Themis Bioscience (ii) them vulnerable to the virus as well as xlv Valneva and (iii) Polymum. people over the age of 70 would be prioritised. Austria is likely to set up xlviii In July, Austria provided €2 million in funding for mobile vaccination teams. the Coalition for Epidemic Preparedness Innovations to advance the development of xlvi xlvii vaccines and equitable distribution COUNTRY DEVELOPMENT AND PROCUREMENT GOVERNANCE STRATEGY PUBLIC ATTITUDES AND (Population) (Taskforce, Plans) (Doses, Target groups, Timelines, COMMUNICATION Delivery) 8
Global Health Governance Programme 21 November 2020 US The U.S. has invested over $12 billion USD in Operation Warp Speed is a public–private CDC has established a work group to In a global survey, 75% of the (360 million) COVID-19 vaccine R&D via Moderna, Johnson & partnership, initiated by the U.S. review evidence for prioritising critical respondents from the US Johnson, Novavax, Astra-Zeneca, and Pfizer; in government to facilitate and accelerate the population groups. These groups may agreed that they will take a li domestic manufacturing; and in domestic development, manufacturing, and include : COVID-19 vaccine if it is distribution efforts, securing 100s of millions of distribution of COVID-19 vaccines, • Critical infrastructure workforce proven safe and effective and xlix liii doses of potential vaccine candidates for the therapeutics, and diagnostics. • People at increased risk for severe is available. American people for potential distribution by COVID-19 illness xlix January 2021. On 29 October, CDC released a detailed • People at increased risk of acquiring or COVID-19 vaccination playbook outlining transmitting COVID-19 US has secured 300 million doses from the entire process of distribution, • People with limited access to routine AstraZeneca, 100 million doses each from Pfizer, administering and monitoring the safety of vaccination services Novovax, and GSK/Sanofi, upon successful vaccines, including priority populations and l lilii approvals and authorisations. US has not public communication. participated in COVAX facility. Canada On September 25th, PM Trudeau pledged a $440 On August 5th, 2020, the federal The National Advisory Committee on Concerns abound over (38 million) million investment to COVAX, of which half will government (including the Minister of Immunization (NACI) has published vaccine hesitancy and towards purchasing vaccines from COVAX for Innovation, Science and Industry and the preliminary guidelines on key inadequate communications Canadians, specifically. liv Minister of Public Services and populations: lviii from health authorities about lix Procurement) announced the - people of advanced age; vaccines. As of Oct. 23rd, 2020, the federal government establishment of the COVID-19 Vaccine - people living with high-risk had pre-ordered and secured 358 million doses Task Force, an advisory panel of conditions; of potential COVID-19 vaccines, including 76 multidisciplinary experts in immunology, - healthcare workers, including those million doses alone from Medicago Inc., a pharmaceutical industry, and vaccinology. who care for the elderly/ work in Quebec-based biotech company who are The task force is supported by the National LTC; essential service workers who lvii currently running two clinical trials authorized by Research Council of Canada. cannot work virtually (e.g. Health Canada. The remaining doses have been firefighters, grocery store staff, etc.); purchased from AstraZeneca, Moderna, and - those who live/ work in settings lv Pfizer. where physical distancing is challenging, healthcare infrastructure As of Nov. 6th, 2020 there are four vaccine is lacking, and/ or where infection candidates for COVID-19 being investigated in could have disproportionate clinical trials authorised by Health Canada (i.e. consequences compared to the the department of the Government of Canada general population (e.g. Indigenous responsible for federal health policy).lvi reservations) COUNTRY DEVELOPMENT AND PROCUREMENT GOVERNANCE STRATEGY PUBLIC ATTITUDES AND (Population) (Taskforce, Plans) (Doses, Target groups, Timelines, COMMUNICATION Delivery) 9
Global Health Governance Programme 21 November 2020 Canada On Nov. 5th, 2020, the Department of Public Works and Government Services released an “Invitation to Qualify” for any potential Logistics Service Providers (companies) to apply to be considered for the execution of the Government of Canada’s COVID-19 vaccine logistics lx strategy. Mexico Mexico has already signed deals with Pfizer, The first to receive the vaccine would be (128 million) AstraZeneca and CanSino for sufficient doses to medical staff and the most dangerous inoculate 117m of its 127m people by the end of cases such as patients with underlying lxi lxiii 2021, if those vaccines get approved. conditions. On Oct. 10th, 2020, the Mexican government announced a nearly $160 million to the COVAX facility. UNAM (Mexico’s main public university), the Mexican Social Security Institute, and private vaccine R&D company Laboratorio Avimex are collaborating on a domestic COVID-19 vaccine candidate that, as of early September, was ready lxii to enter phase 1 trials. Mexico has agreed to host human trials of seven Covid-19 vaccines to strengthen relations with pharmaceutical companies in case limited production capacity leads to a battle for doses. South Korea South Korea will buy 20 million doses through The 5th meeting of a pan-government The South Korean government have set There is a high willingness to (51 million) COVAX, enough for 10 million people, and 40 support committee for the treatment of the target of securing enough vaccine accept a COVID-19 vaccine in million doses from private drug-makers including COVID-19 and development of a vaccine doses for all 50 million citizens, with a South Korea (exceeding 80%), AstraZeneca, Novavax, Pfizer, Moderna and held on August 21st made reference to a minimum national target of 70% with strong trust from in lxiv . Johnson & Johnson. Local corporations engaging ‘two-pronged’ approach involving (1) local coverage, to acquire herd immunity. central government liii in clinical trials for the development of (five) corporation support and (2) international therapeutic treatments and (three) vaccine community. candidates are receiving government funding (estimated $83 million). COUNTRY DEVELOPMENT AND PROCUREMENT GOVERNANCE STRATEGY PUBLIC ATTITUDES AND (Population) (Taskforce, Plans) (Doses, Target groups, Timelines, COMMUNICATION Delivery) 10
Global Health Governance Programme 21 November 2020 Taiwan The Taiwan government will allocate US$635.6 In April, the government-sponsored Priority groups for the vaccine include The government of Taiwan (23 million) million for the development or procurement of a National Health Research Institutes (NHRI) health professionals, senior and more has secured high levels of lxv COVID-19 vaccine. established a “national team” for vulnerable citizens. public trust for their facilitating development of vaccines and responses to coronavirus. In Under the agreement with Pfizer and BioNTech, treatments for coronavirus (COVID-19). Taiwan, YouGov polls in May Taiwan can acquire up to 30 million COVID-19 showed that public trust in vaccine doses, with 10 million expected to be In June, the health minister announced a the government and delivered in the first quarter of 2021. new special task force will be formed to healthcare professionals on speed up the development of a COVID-19 COVID-19 was very high – at lxvi Taiwan has also joined the COVAX Facility. vaccine. over 80%. Over the years, lxv the government, particularly Two local vaccine candidates have been the Digital Ministry led by developed in Taiwan and are currently being Audrey Tang, has worked to tested. Although, challenges for vaccine trials in increase a direct dialogue Taiwan include lack of standard parameter for between government officials evaluating vaccine productivity and number of and citizens and responding subjects required for representing vaccine safety to disinformation across as no locally acquired COVID-19 cases since May, lxvii media channels. 2020. Japan Japan is on track to have 521 million doses of five In August, Japan’s coronavirus task force Japan will prioritize administering (126 million) different vaccines in 2021, compared with a drafted vaccination guidelines, prioritising coronavirus vaccines to certain groups of lxviii population of 126 million. Apart from joining medical workers, older people and those the population. Those wishing for a the COVAX Facility, the Japanese government has with underlying illnesses. The task force vaccine will be inoculated for free at pledged a budget of ¥671.4 billion and signed will also consider whether pregnant health care facilities by submitting special agreements with AstraZeneca and Pfizer, to women, emergency responders and staff at coupons to be distributed by local receive 120 million doses of vaccines from each public health centers should be included in municipalities. They will also receive a lxxi company, when successfully developed. the priority group for vaccination. certificate upon vaccination, according to lxxii Negotiations with Moderna for 40 million or the ministry. more additional dose are underway. Japan also has a local vaccine candidate currently being lxix tested. Novavax have granted Takeda a license to manufacture and commercialise its vaccine in Japan, with a preliminary estimate of 250 million lxx Novavax to be produced each year. COUNTRY DEVELOPMENT AND PROCUREMENT GOVERNANCE STRATEGY PUBLIC ATTITUDES AND (Population) (Taskforce, Plans) (Doses, Target groups, Timelines, COMMUNICATION Delivery) 11
Global Health Governance Programme 21 November 2020 Hong Kong Hong Kong has procured COVID-19 vaccine doses The government has in place a scientific Hong Kong government health adviser, A preprint study on nurses’ (7.5 million) from at least two types of vaccine candidates committee on vaccine-preventable said he expected the vaccination schedule hesitancy to accept a COVID- from the list of 9 CEPI potential vaccines, to cover diseases, responsible for tracking will be similar to the seasonal influenza 19 vaccine in Hong Kong 35% of its population. Hong Kong has also joined candidates in the final stage of vaccine, in which the elderly, chronically ill suggested that only around lxxiv the COVAX Facility. The University of Hong development around the world. patients, and medical workers will be the 63% participants (of a sample lxxv Kong/Xiamen University have a dual COVID- first vaccinated. of 1203) had an intent to opt- 19/influenza nasal spray, CEPI-supported, in for a COVID-19 vaccine, lxxiii preclinical vaccine candidate. when it becomes lxxvi available. Singapore Singapore plans to secure vaccine doses through Singapore's 14-member COVID-19 vaccine Priority to protect individuals who are There is a high willingness to (5 million) its partnership with the COVAX Facility. The expert committee was unveiled on Nov 12, most vulnerable or at high risk from the accept a COVID-19 vaccine in country also has a local vaccine candidate being to assess the effectiveness and safety of disease, as well as those who may be Singapore (exceeding 80%), lxxvii lxix tested. the vaccine and identify priority groups for more likely exposed to infection, while with strong trust from in lxxviiilxxix liii vaccination. working progressively towards a high level central government. of vaccination in the population. 12
Global Health Governance Programme 21 November 2020 References: i Oxfam. 2020. Small group if rich nations have bought up more than half of the future supply of leading COVID-19 vaccine contenders. https://www.oxfam.org/en/press-releases/small-group-rich-nations-have- bought-more-half-future-supply-leading-covid-19 ii Lazarus, J.V., Ratzan, S.C., Palayew, A. et al. A global survey of potential acceptance of a COVID-19 vaccine. Nat Med (2020). https://doi.org/10.1038/s41591-020-1124-9. iii Elgot J and Sample I. 2020. UK scrambles to buy 5m doses of Covid breakthrough vaccine https://www.theguardian.com/world/2020/nov/16/uk-in-advanced-discussions-to-buy-moderna-covid- vaccine iv Bingham K. The UK Government's Vaccine Taskforce: strategy for protecting the UK and the world. The Lancet. 2020 Oct 27. https://www.thelancet.com/action/showPdf?pii=S0140-6736%2820%2932175-9 v Devex. UK joins COVAX scheme on deadline day. Accessed 2020 Nov 9. https://www.devex.com/news/uk- joins-covax-scheme-on-deadline-day-98132 vi Department of Health and Social Care, Government of the United Kingdom. JCVI: updated interim advice on priority groups for COVID-19 vaccination. Accessed 2020 Nov 9. https://www.gov.uk/government/publications/priority-groups-for-coronavirus-covid-19-vaccination-advice- from-the-jcvi-25-september-2020/jcvi-updated-interim-advice-on-priority-groups-for-covid-19-vaccination vii Financial Times. Less than half UK population to receive coronavirus vaccine, says task force head. Accessed 2020 Nov 9. https://www.ft.com/content/d2e00128-7889-4d5d-84a3-43e51355a751 viii Government of the United Kingdom. A statement regarding Kate Bingham and the Vaccine Taskforce. Accessed 2020 Nov 9. https://www.gov.uk/government/news/a-statement-regarding-kate-bingham-and-the- vaccine-taskforce ix WHO, 2020. DRAFT Landscape of COVID-19 Candidate Vaccines - 3 November 2020. [online] p.3. Available at: [Accessed 6 November 2020]. x Gavi.org. 2020. COVAX Commitment Agreements. [online] Available at: [Accessed 5 November 2020]. xi GAVI: The Vaccine Alliance, 2020. Key Outcomes: COVAX AMC. [online] Available at: [Accessed 7 November 2020]. xii https://www.rki.de/EN/Content/infections/Vaccination/Vaccination_node.html xiii https://www.dw.com/en/germany-to-set-up-hundreds-of-vaccination-centers-from-december-report/a- 55605652 xiv Bundesministerium für Gesundheit, 2020. Durchführung Und Organisation Der COVID-19 Pandemieimpfung In 2 Phasen. p.1. xv Bundesgesundheitsministerium. 2020. Chronik Zum Coronavirus SARS-Cov-2. [online] Available at: [Accessed 7 November 2020]. xvi Ibid. xvii https://www.dw.com/en/germany-to-set-up-hundreds-of-vaccination-centers-from-december-report/a- 55605652 xviii Markovitz, G. and Russo, A., 2020. Survey Shows Rising Vaccine Hesitancy Threatening COVID-19 Recovery. [online] World Economic Forum. Available at: [Accessed 7 November 2020]. xix Ellyatt, H., 2020. Four European Nations To Pay $843 Million For Astrazeneca’S Coronavirus Vaccine. [online] CNBC. Available at: [Accessed 5 November 2020]. xx https://www.reuters.com/article/us-health-coronavirus-france-trials-idUSKBN26M6CH xxi https://www.connexionfrance.com/French-news/France-sets-out-future-Covid-19-coronavirus-vaccine- vaccination-priority-plan-for-at-risk-and-vulnerable-workers-and-people xxii Ministry of Health, 2020. VACCINS CONTRE LE SARS-Cov-2: UNE STRATEGIE DE VACCINATION. xxiii Ibid. xxiv Ibid. xxv Ibid. 13
Global Health Governance Programme 21 November 2020 xxvi Ibid. xxvii https://www.thelocal.it/20201118/how-italy-is-preparing-for-a-covid-19-vaccine xxviii Angela Betsaida B. Laguipo, B., 2020. Italy Starts Human Trials Of Potential COVID-19 Vaccine. [online] News-Medical.net. Available at: [Accessed 5 November 2020]. xxix https://www.thelocal.it/20201118/how-italy-is-preparing-for-a-covid-19-vaccine xxx Salute, M., 2020. Covid-19 Vaccine Will Be Free, 1St Doses In Autumn Says Speranza. [online] Salute.gov.it. Available at: [Accessed 5 November 2020]. xxxi Nugent, C. and Ducharme, J., 2018. Why Is Italy's Government Trying To Overturn A Lifesaving Vaccination Law? Here's What To Know. [online] Time. Available at: [Accessed 6 November 2020]. xxxii Mezzofiore, G., 2018. Why Italy's U-Turn On Mandatory Vaccination Shocks The Scientific Community. [online] CNN. Available at: [Accessed 6 November 2020]. xxxiii Palamenghi, L., Barello, S., Boccia, S. and Graffigna, G., 2020. Mistrust in biomedical research and vaccine hesitancy: the forefront challenge in the battle against COVID-19 in Italy. European Journal of Epidemiology, 35(8), pp.785-788. xxxiv GAVI: The Vaccine Alliance, 2020. Key Outcomes: COVAX AMC. [online] Available at: [Accessed 7 November 2020]. xxxv TornosNews.GR. 2020. Greek Minister: We Are Drafting The Coronavirus Vaccination Business Plan | Tornosnews.Gr. [online] Available at: [Accessed 7 November 2020]. xxxvi https://in.reuters.com/article/us-health-coronavirus-greece-vaccination/greece-makes-vaccination-plans- urges-patience-as-covid-cases-rise-idUSKBN27Y2IR xxxvii WHO, 2020. DRAFT Landscape Of COVID-19 Candidate Vaccines - 3 November 2020. [online] p.3. Available at: [Accessed 6 November 2020]. xxxviii Mitchell, D., 2020. Spain Will Manufacture The U.S. Novavax Vaccine Against Covid-19. [online] Euro Weekly News Spain. Available at: [Accessed 6 November 2020]. xxxix Gavi.org. 2020. CEPI Expands Global Manufacturing Network, Reserving Manufacturing Capacity For More Than 1 Billion Doses Of COVID-19 Vaccines. [online] Available at: [Accessed 6 November 2020]. xl Mitchell, D., 2020. Spain Will Manufacture The U.S. Novavax Vaccine Against Covid-19. [online] Euro Weekly News Spain. Available at: [Accessed 6 November 2020]. xli Thisistherealspain.com. 2020. Spain, Again Chosen To Produce The Vaccine To Combat Covid-19. [online] Available at: [Accessed 6 November 2020]. xlii thinkSPAIN. 2020. Two Spanish Companies Manufacturing Covid Vaccines. [online] Available at: [Accessed 6 November 2020]. xliii https://english.elpais.com/society/2020-11-10/spain-hopes-to-have-pfizer-vaccine-for-10-million-people- by-early-2021.html xliv https://english.elpais.com/society/2020-08-26/30-of-spaniards-have-doubts-about-being-vaccinated- against-covid-19-poll-reveals.html xlv Eine Information des ÖVIH – Österreichischer Verband der Impfstoffhersteller, 2020. Virtueller Medien- Workshop: Impfstoffentwicklung Gegen Covid-19. [online] Vienna: APA Press Center. Available at: [Accessed 7 November 2020]. 14
Global Health Governance Programme 21 November 2020 xlvi Pharmashots.com. 2020. Austria Donates €2 Million To CEPI To Support COVID-19 Vaccine Programmes | Pharmashots. [online] Available at: [Accessed 7 November 2020]. xlvii CEPI. 2020. Austria Donates €2 Million To CEPI To Support COVID-19 Vaccine Programmes – CEPI. [online] Available at: [Accessed 7 November 2020]. xlviii https://www.thelocal.at/20201112/when-will-the-coronavirus-vaccine-be-available-in-austria xlix US Department of Health and Human Services. Fact Sheet: Explaining Operation Warp Speed. Accessed 2020 Nov 9. https://www.hhs.gov/coronavirus/explaining-operation-warp-speed/index.html l US Centers for Disease Control. Frequently Asked Questions about COVID-19 Vaccination. Accessed 2020 Nov 9. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/faq.html li US Centers for Disease Control. COVID-19 Vaccination Program Interim Playbook for Jurisdiction Operations. Accessed 2020 Nov 9. https://www.cdc.gov/vaccines/imz-managers/downloads/COVID-19-Vaccination- Program-Interim_Playbook.pdf lii US Department of Health and Human Services. From the Factory to the Frontlines: The Operation Warp Speed Strategy for Distributing a COVID-19 Vaccine. Accessed 2020 Nov 9. https://www.hhs.gov/sites/default/files/strategy-for-distributing-covid-19-vaccine.pdf liii Lazarus, J.V., Ratzan, S.C., Palayew, A. et al. A global survey of potential acceptance of a COVID-19 vaccine. Nat Med (2020). https://doi.org/10.1038/s41591-020-1124-9 liv CBC News. Canada snapping up COVID-19 vaccines at expense of poorer countries, experts say. Accessed 2020 Nov 8. https://www.cbc.ca/news/canada/ottawa/covid-19-vaccines-canada-covax-insufficient- contribution-global-health-experts-1.5741693 lv CBC News. Trudeau announces plan to purchase 76 million doses of Canadian-made COVID-19 vaccine. Accessed 2020 Nov 4. https://www.cbc.ca/news/politics/trudeau-vaccine-rapid-tests-1.5774309 lvi Medicago. MEDICAGO SIGNS AGREEMENTS WITH THE GOVERNMENT OF CANADA TO SUPPLY UP TO 76 MILLION DOSES OF ITS RECOMBINANT PLANT-DERIVED COVID-19 VACCINE. Accessed 2020 Nov 4. https://www.medicago.com/en/newsroom/medicago-signs-agreements-with-the-government-of-canada-to- supply-up-to-76-million-doses-of-its-recombinant-plant-derived-covid-19-vaccine/ lvii Government of Canada. Government of Canada announces major steps in treating and preventing COVID-19 through vaccines and therapies. Accessed 2020 Nov 5. https://www.canada.ca/en/innovation-science- economic-development/news/2020/08/government-of-canada-announces-major-steps-in-treating-and- preventing-covid-19-through-vaccines-and-therapies.html lviii Government of Canada. Preliminary guidance on key populations for early COVID-19 immunization. Accessed 2020 Nov 8. https://www.canada.ca/en/public-health/services/immunization/national-advisory- committee-on-immunization-naci/guidance-key-populations-early-covid-19-immunization.html lix Global News. Hesitancy over a COVID-19 vaccine may threaten public health. Accessed 2020 Nov 8. https://globalnews.ca/news/7446769/vaccine-hesitancy-covid-19-public-health-threat/ lx National Research Council Canada. COVID-19 response: Building the infrastructure. Accessed 2020 Nov 8. https://nrc.canada.ca/en/covid-19-response-building-infrastructure lxi https://www.ft.com/content/8beceb2f-14b1-4071-9283-0307159feff2 lxii NBC News. Mexico aims to produce its own coronavirus vaccine. Accessed 2020 Nov 9. https://www.nbcnews.com/news/latino/mexico-aims-produce-its-own-coronavirus-vaccine-n1239500 lxiii https://www.aa.com.tr/en/asia-pacific/mexico-signs-deal-to-secure-covid-19-vaccine/2005415# lxiv Korea.net. Gov’t eyes COVID-19 vaccines for at least 70% of population. 2020. http://www.korea.net/Government/Current-Affairs/National- Affairs/view?affairId=2034&subId=5&articleId=189029&viewId=56467 lxv https://www.taiwannews.com.tw/en/news/3922322 lxvi https://theconversation.com/what-coronavirus-success-of-taiwan-and-iceland-has-in-common-140455 lxvii https://www.brookings.edu/blog/order-from-chaos/2020/09/15/taiwans-unlikely-path-to-public-trust- provides-lessons-for-the-us/ lxviii https://www.livemint.com/news/world/why-japan-ordered-covid-vaccines-four-times-its-entire- population-11598591799334.html lxix NIH Clinical Trials. Study of COVID-19 DNA Vaccine (AG0301-COVID19). 2020. https://clinicaltrials.gov/ct2/show/NCT04463472 lxx BioPharma. Takeda sets up deal to distrubte Moderna’s COVID-19 vaccine in Japan .2020. https://www.biopharma-reporter.com/Article/2020/08/31/Takeda-sets-up-deal-to-distribute-Moderna-s- COVID-19-vaccine-in-Japan 15
Global Health Governance Programme 21 November 2020 lxxi https://www.japantimes.co.jp/news/2020/08/22/national/japan-medical-staff-elderly-coronavirus-vaccine/ lxxii https://www.japantimes.co.jp/news/2020/11/10/national/science-health/prioritize-older-people- administering-coronavirus-vaccines/ lxxiii News.gov.hk. Vaccine procurement plan explained. 2020. https://www.news.gov.hk/eng/2020/09/20200918/20200918_140407_591.html lxxiv https://www.scmp.com/news/hong-kong/health-environment/article/3101028/hong-kong-health-experts- say-delay-astrazeneca lxxv The Standard. Vaccine first buy good for 35pc of Hongkongers. 2020. https://www.thestandard.com.hk/section-news/section/11/222652/Vaccine-first-buy-good-for-35pc-of- Hongkongers lxxvi Kwok KO, Li KK, Wei WI, Tang KH, Wong SYS, Lee SS. Are we ready when COVID-19 vaccine is available? Study on nurses′ vaccine hesitancy in Hong Kong. medRxiv 2020. Preprint. lxxvii World Health Organization. 172 countries and multiple candidate vaccine candidates engaged in COVID-19 Global Access Facility. 2020. https://www.who.int/news/item/24-08-2020-172-countries-and-multiple- candidate-vaccines-engaged-in-covid-19-vaccine-global-access-facility lxxviii https://www.straitstimes.com/singapore/health/who-should-be-first-to-get-access-to-vaccine lxxix https://www.youtube.com/watch?v=6W0V5L9gs8U 16
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