CONGRESS ON BIOCATALYSIS - 9th INTERNATIONAL CONGRESS PROGRAMME - 9th International Congress on ...
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9th INTERNATIONAL
CONGRESS
ON BIOCATALYSIS
CONGRESS PROGRAMME
26–30 AUGUST 2018
HAMBURG UNIVERSITY OF TECHNOLOGY l GERMANY
© Technische Universität Hamburg
Programme overview
Sunday, Monday, Tuesday,
26 August 27 August 28 August
Building H Audimax I Room H0.01–H0.09 Audimax I Room H0.01–H0.09
08:30–10:30 08:30–10:30
Invited speaker Invited speaker
session 1 session 2
Topic 2 Topic 3
p. 9 p. 14
Coffee break and industrial exhibition Coffee break and industrial exhibition
11:00–13:10 11:00–12:40
Morning session 1 Industrial
Topics 2+1 implementations
Morning session 2
Topic 5
p. 14
p. 9
Lunch at Mensa
Lunch at Mensa
14:00–15:00 14:00–15:30
Lightning talk Poster session 2
14:30–15:30 14:30–16:30 Session 2 Topic 1
Lightning talk Poster session 1 Topic 1 p. 15
session 1 Topic 3
Topic 3 p. 10 p. 35
15:30–17:00 Coffee break and industrial exhibition
Registration 15:50–16:50
Industrial
p. 26 implementations
Coffee break and industrial exhibition Afternoon session 2
p. 8 16:50–18:10 Topic 1 p. 17
17:00–18:45 Afternoon session 1 17:00–22:30
Opening ceremony Topic 4 Congress dinner on the boat
Louisiana Star
p. 12 p. 56
p. 8
19:00–22:00
Welcome reception
p. 8
2
Programme overview
Wednesday, Thursday,
29 August 30 August
Audimax I Room H0.01–H0.09 Ditze Lecture Hall Audimax I
08:30–10:30
Invited speaker
09:00–11:00 session 4
Invited speaker Topic 3+4
session 3
Topic 1
p. 24
Coffee break and
p. 18 industrial exhibition
11:00–13:00
Coffee break and industrial exhibition
Industrial
11:30–13:20 11:30–13:20 implementations
Morning session 3 Morning session 4 Morning session 5
Topics 5+2 Topics 2+3 Topic 3
p. 24
p. 18 p. 19 13:00–13:30
Closing remarks
p. 25
Lunch at Mensa
14:40–15:50 14:40–16:40
Lightning talk Poster session 3
session 3 Topics 2+4+5
Topics 2+4+5
p. 19
p. 43
Coffee break and industrial exhibition
17:00–18:00 17:00–18:00
Afternoon session 3 Afternoon session 4
Topic 3 Topic 2
p. 22 p. 22
Registration
Opening/Closing/Social programme
Session
Poster session
Lightning talk session
26–30 August 2018
Hamburg University of Technology l Germany 3
Table of contents
Organisation and imprint ....................................................................................................... 5
Committees ............................................................................................................................ 6
Welcome note ........................................................................................................................ 7
Scientific programme
Sunday, 26 August ........................................................................................................ 8
Monday, 27 August ...................................................................................................... 9
Tuesday, 28 August ...................................................................................................... 14
Wednesday, 29 August ................................................................................................ 18
Thursday, 30 August . ................................................................................................... 24
Poster presentations
Monday, 27 August ...................................................................................................... 26
Tuesday, 28 August ...................................................................................................... 35
Wednesday, 29 August ................................................................................................ 43
Sponsors, exhibitors and media cooperations . .................................................................... 54
Floor plan ................................................................................................................................ 55
Social programme .................................................................................................................. 56
General information ............................................................................................................... 57
General tips for authors and presenters ............................................................................... 59
Index of authors and chairs . .................................................................................................. 60
4
Organisation and imprint Venue Hamburg University of Technology (TUHH) Audimax I Am Schwarzenberg-Campus 5 21073 Hamburg, Germany Date 26–30 August 2018 Congress website www.biocat-conference.de Congress organisation and industrial exhibition Conventus Congressmanagement & Marketing GmbH Dana Nostitz Carl-Pulfrich-Straße 1 07745 Jena, Germany Phone +49 3641 31 16-398 biocat2018@conventus.de www.conventus.de Design/layout Layout krea.tif-studio UG (haftungsbeschränkt) Print siblog – Gesellschaft für Dialogmarketing, Fulfillment & Lettershop mbH Circulation 400 Editorial deadline 6 August 2018 26–30 August 2018 Hamburg University of Technology l Germany 5
Committees Congress chair Prof. Dr. Dr. h.c. Garabed Antranikian Hamburg University of Technology (TUHH) Technical Microbiology V-7 Kasernenstraße 12 (F) 21073 Hamburg, Germany Local organizing committee Anna Krüger Hamburg University of Technology, Germany Petra Esselun Hamburg University of Technology, Germany Andreas Liese Hamburg University of Technology, Germany Christian Schäfers Hamburg University of Technology, Germany Carola Schröder Hamburg University of Technology, Germany Ralf Grote Hamburg University of Technology, Germany Scientific advisory board Carolina Andrade SENAI, Brazil Yasuhisa Asano Toyama Prefectural University, Japan Haruyuki Atomi Kyoto University, Japan Christoph Bolten Nestlé Research Center, Switzerland Uwe T. Bornscheuer University of Greifswald, Germany Thomas Brück Technical University of Munich, Germany Arnold Driessen University of Groningen, Netherlands Kurt Faber University of Graz, Austria Laurence Hecquet University Clermont Auvergne, France Stefan Heinrich Hamburg University of Technology, Germany Gjalt Huisman Codexis, USA Romas Kazlauskas University of Minnesota, USA Martin Keller National Renewable Energy Laboratory, USA Byung-Gee Kim Seoul National University, Korea Andreas Kohl Clariant, Germany Vladimír Křen Czech Academy of Sciences, Czech Republic Wolfgang Kroutil University of Graz, Austria Karl-Heinz Maurer AB Enzymes, Germany Pierre Monsan National Institute of Applied Science, France Marco Moracci University of Naples ‘Federico II’, Italy Mosè Rossi National Council of Research of Italy, Italy Nicholas Turner The University of Manchester, United Kingdom Alex Zaks Akermin, USA An-Ping Zeng Hamburg University of Technology, Germany 6
Welcome note Dear colleagues, Developing a bio-based economy is a worldwide strategy to address the global challenges of dwindling fossil energy reserves, environmental pollution and climate change in the light of a growing world population. Biocatalysis is one of the key technologies to address this complex task helping to produce sustainable raw materials and energy supply from biomass, while at the same time taking responsibility for the world’s food supply. Biotechnological products already find application in food, feed, chemical, pharmaceutical and cosmetics industry and the developing bioeconomy is expected to create new processes and products and new job opportunities. To face the current enormous and diverse challenges bridging the gap between research and markets of the future is particularly important. The successful concept of biocat is due to an interdisciplinary approach integrating the know-how of highly acknowledged biologists, biochemists, chemists and engineers from academia and industry. Biocat offers a platform to form strategic alliances for future projects and innovations. It is my great pleasure and honor to invite scientists from all over the world to the 9th Inter- national Congress on Biocatalysis 2018 (biocat2018) to be held from August 26–30, 2018 at the Hamburg University of Technology (TUHH), Germany. Since 2002 we have been organizing the biennial biocat congress series, which is focused on the rapidly evolving fields of biocatalysis and industrial biotechnology. The preceding International Congresses on Biocatalysis attracted more than 2,900 participants from over 40 countries. The major topics to be addressed are: Topic 1 – Enzyme discovery, production and application Topic 2 – Structure-function analysis and enzyme design Topic 3 – Enzymatic and whole cell biotransformations Topic 4 – Bioprocess engineering and downstream processing Topic 5 – Sustainable industrial processes, biorefinery and bioeconomy It is our aim to create a stimulating and open scientific atmosphere to foster the development of new collaborations. We are looking forward to welcoming you in Hamburg, an exciting and cosmopolitan city, and to share a successful and enjoyable meeting with you. Garabed Antranikian 26–30 August 2018 Hamburg University of Technology l Germany 7
General Information
Programme l sunday, 26 august
15:30–17:00 REGISTRATION
Building H
17:00–18:45 OPENING CEREMONY
Audimax I Garabed Antranikian (Hamburg/DE)
Music
SwingING. Bigband
© www.gero-weiland.de/de/105706-SwingING-Big-Band
17:45 Directed evolution of stereoselective enzymes – a prolific source of
OL1 catalysts for asymmetric reactions
Manfred T. Reetz (Mülheim an der Ruhr/DE)
18:15 Synthetic biochemistry at GSK
OL2 Joe Adams (Stevenage/GB)
19:00–22:00 WELCOME RECEPTION
Building I, Mensa
8ProgrammeGeneral
l monday,
Information
27 august
08:30–10:30 INVITED SPEAKER SESSION 1 – TOPIC 2
Audimax I Structure-function analysis and enzyme design
Chair Byung-Gee Kim (Seoul/KR)
08:30 Engineering oxidative flavoenzymes for industrial processes
IL2-1 Marco W. Fraaije (Groningen/NL)
09:00 Dissecting prokaryotic polyunsaturated fatty acid synthases
IL2-2 Tohru Dairi (Hokkaido/JP)
09:30 Recent advances in the discovery, engineering and application of
IL2-3 monooxygenases
Uwe T. Bornscheuer (Greifswald/DE)
10:00 Imine reductases in the stereoselective synthesis of
IL2-4 N-heterocyclic amines
Bettina Nestl (Stuttgart/DE)
10:30–11:00 Coffee break and industrial exhibition
11:00–13:10 MORNING SESSION 1 – TOPICS 2+1
Audimax I Structure-function analysis and enzyme design + Enzyme discovery,
production and application
Chair Uwe T. Bornscheuer (Greifswald/DE)
11:00 Archaeal metabolism and its application
IL1-4 Haruyuki Atomi, Takaaki Sato, Tamotsu Kanai (Kyoto/JP)
11:30 Biocatalytic production of quercetin with rutinosidase – novel concept
L1-1 of “solid state biocatalysis”
Vladimír Křen, Jana Kapesova, Michal Kotik
Lucie Petraskova (Prague/CZ), Martin Rebros
Kristina Markosova (Bratislava/SK)
11:50 A prolyl endopeptidase from Flammulina velutipes for the improved
L1-2 processing of celiac disease provoking cereal proteins
Kathrin Schulz, Lucienne Giesler, Diana Linke
Ralf Günter Berger (Hannover/DE)
12:10 Actinobacterial genomes – a treasure trove of oxidative enzymes
L1-3 Marilize Le Roes-Hill (Bellville/ZA)
Kim Durrell (Bellville, Stellenbosch/ZA), Alaric Prins (Bellville/ZA)
Amos Musengi (Harare/ZW), Tukayi Kudanga (Durban/ZA)
26–30 August 2018
Hamburg University of Technology l Germany 9General Information
Programme l monday, 27 august
12:30 Biocatalytic degradation of synthetic polymers with thermophilic
L1-4 bacterial polyester hydrolases
Ren Wei, Wolfgang Zimmermann (Leipzig/DE)
12:50 Purification and characterization of a viral RNA polymerase isolated from
L1-5 an antarctic environmental sample
Jenny Blamey, Giannina Espina (Santiago/CL), Michael Goodson
Nancy Kelley-Loghnane, Svetlana Harbaugh
Irina Drachuk (Wright Patterson Air Force Base, OH/US), Javiera Aviles
Belen Rickmers (Santiago/CL)
13:10–14:30 Lunch at Mensa
14:30–16:30 POSTER SESSION 1 – TOPIC 3 (see page 26)
Enzymatic and whole cell biotransformations – P3-1–P3-78
14:30–15:30 LIGHTNING TALK SESSION 1 – TOPIC 3
Audimax I Enzymatic and whole cell biotransformations
Chair Andreas Liese (Hamburg/DE)
P3-1 Finally – diterminal oxidation of medium chain alkanes
Youri van Nuland, Gerrit Eggink, Ruud Weusthuis (Wageningen/NL)
P3-2 Aldol additions of pyruvate analogs to formaldehyde — synthesis of
optically active β-hydroxycarboxylic esters
Pere Clapes, Karel Hernández, Jordi Bujons, Jesús Joglar
Roser Marín (Barcelona/ES)
P3-3 Biosynthesis of N-heterocycles from diamine at the expense of
molecular oxygen and molecular hydrogen
Ammar Al-Shameri (Berlin/DE), Niels Borlinghaus
Bettina Nestl (Stuttgart/DE), Lars Lauterbach (Berlin/DE)
P3-4 Compartmentalized aqueous-organic emulsions for efficient biocatalysis
Changzhu Wu (Odense M/DK)
P3-5 Accessing enantiopure epoxides and sulfoxides via group E
monooxygenases
Thomas Heine, Anika Scholtissek, Lucas Siegel, Sarah Hofmann
Xiaoqi Gao, Philipp Rathsack (Freiberg/DE)
Dirk Tischler (Freiberg, Bochum/DE)
10ProgrammeGeneral
l monday,
Information
27 august
P3-6 Selective aerobic oxidation of C-H bonds by combining photochemistry
and biocatalysis
Wuyuan Zhang, Elena Fernández-Fueyo, Yan Ni, Morten van Schie
Jenö Gacs, Bastien O. Burek, Jonathan Z. Bloh, Rokus Renirie
Ron Wever, Francesco G. Mutti, Dörte Rother, Miguel Alcalde
Frank Hollmann (Delft/NL)
P3-7 Whole cell biocatalyst expressing a surface-displayed P450 allows for
efficient hydroxylation reactions
Marcus Probst, Cindy Kunze (Frankfurt am Main/DE), Eva Kranen
Ruth Maas (Düsseldorf/DE), Dirk Holtmann (Frankfurt am Main/DE)
P3-8 Ionization basis for activation of enzymes in zwitterionic liquids
Guangnan Ou, Biyan He (Xiamen/CN)
P3-9 Model optimization of DERA-catalyzed double aldol addition
Ana Vrsalović Presečki, Anera Švarc, Đurđa Vasić-Rački (Zagreb/HR)
Karel Hernandez, Pere Clapés (Barcelona/ES)
Zvjezdana Findrik Blažević (Zagreb/HR)
P3-10 Enzyme catalysed synthesis of esters in water
Ulf Hanefeld (Delft/NL)
P3-11 New bioactive prodigiosin derivatives – a bridge between chemistry and
biology
Hannah U. C. Braß, Andreas S. Klein, Thomas Classen, Anita Loeschcke
Thomas Drepper (Jülich/DE), Sonja Sievers (Dortmund/DE)
Karl-Erich Jaeger, Jörg Pietruszka (Jülich/DE)
P3-12 Enrichment of mono-unsaturated long chain fatty acids from camelina
and crambe seed oils by engineered lipase variants
Isabel Oroz-Guinea, Katja Zorn, Henrike Brundiek
Uwe T. Bornscheuer (Greifswald/DE)
P3-13 Catalytic properties of the fluoroketone reductase from
Pichia farinosa NBRC0462
Sayaka Kamai, Sayaka Shichida (Imizu, Toyama/JP)
Shinsuke Miki (Kawagoe/JP), Kimiyasu Isobe, Makoto Hibi
Yasuhisa Asano (Imizu, Toyama/JP)
26–30 August 2018
Hamburg University of Technology l Germany 11General Information
Programme l monday, 27 august
P3-14 Microbial electrosynthesis of chiral alcohols using resting recombinant
Escherichia coli cells
Jeannine Mayr (Braunschweig/DE), Luis F. M. Rosa (Leipzig/DE)
Jan-Hendrik Grosch (Braunschweig/DE), Falk Harnisch (Leipzig/DE)
Antje C. Spiess (Braunschweig/DE)
P3-15 Stereoselective one-pot enzyme cascade towards
γ‑butyrolactone fragrances
Ceyda Kumru, Thomas Classen, Jörg Pietruszka (Jülich/DE)
P3-16 Synthesis of syringaresinol from 2,6-dimethoxy-4-allylphenol using
an oxidase/peroxidase enzyme system
Mohamed Habib (Groningen/NL; Cairo/EG), Milos Trajkovic
Marco W. Fraaije (Groningen/NL)
P3-17 Biocatalysis alternatives dedicated to flavors and fragrances production
Madalina Tudorache, Sabina Ion, Cristina Sora, Simona Reznicencu
Vasile Parvulescu (Bucharest/RO)
P3-18 Aromatic hydroxylases as part of enzymatic cascading reactions
Martin Dippe, Susann Hermann, Benjamin Weigel
Ludger Wessjohann (Halle an der Saale/DE)
16:30–16:50 Coffee break and industrial exhibition
16:50–18:10 AFTERNOON SESSION 1 – TOPIC 4
Audimax I Bioprocess engineering and downstream processing
Chair Marco Moracci (Naples/IT)
16:50 Application of periodic counter-current chromatography for the
L4-1 continuous purification of industrial relevant proteins
Chantal Brämer, Thomas Scheper, Sascha Beutel (Hannover/DE)
17:10 Process considerations for overcoming major hurdles in amine
L4-2 transaminase catalysed synthesis of chiral amines – strategies for
resolving issues with stability, inhibition and thermodynamic limitations
Carl Grey (Lund/SE)
17:30 Combination of enantioselective chromatography and enzymatic
L4-3 racemization – initial characterization and experimental demonstration
Katarzyna Wrzosek, Isabel Harriehausen
Andreas Seidel-Morgenstern (Magdeburg/DE)
17:50 Stepwise cascade reaction for cofactor supply of enzymatic oxidations
L4-4 Florian Busch (Geleen/NL; Bochum/DE), Martin Schürmann (Geleen/NL)
Robert Kourist (Graz/AT)
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Germany www.c-LEcta.comGeneral Information
Programme l tuesday, 28 august
08:30–10:30 INVITED SPEAKER SESSION 2 – TOPIC 3
Audimax I Enzymatic and whole cell biotransformations
Chair Haruyuki Atomi (Kyoto/JP)
08:30 Production of omega-hydroxy fatty acids using biocatalysis
IL3-1 Hee-Wang Yoo, Bum-Gi Park, Sung-Youn Joo, Hyungdon Yoon
Byung-Gee Kim (Seoul/KR)
09:00 Enzymatic and microbial conversion of waste plastics
IL3-2 Harry P. Austin, Mark D. Allen (Portsmouth/GB), Bryon S. Donohoe
Mary Ann Franden, Lahiru Jayakody
Christopher W. Johnson (Golden, CO/US), Fiona Kearns (Tampa, FL/US)
Nicholas A. Rorrer (Golden, CO/US), H. Lee Woodcock (Tampa, FL/US)
John E. McGeehan, Gregg Beckham (Golden, CO/US)
09:30 Discovery and development of novel glucanotransferases for healthier
IL3-3 foods
Tim Börner (Lausanne/CH), Joana Gangoit (Groningen/NL), Lisa Lamothe
Stéphane Duboux (Lausanne/CH), S. van Leeuwen
Lubbert Dijkhuizen (Groningen/NL), Christina Vafeiadi (Lausanne/CH)
10:00 Exploring and engineering the application potential of GH13
IL3-4 glycosyltransferases
Tom Desmet (Gent/BE)
10:30–11:00 Coffee break and industrial exhibition
11:00–12:40 INDUSTRIAL IMPLEMENTATIONS – MORNING SESSION 2 – TOPIC 5
Audimax I Sustainable industrial processes, biorefinery and bioeconomy
Chair Andreas Kohl (Planegg/DE)
11:00 Self-sufficient co-immobilized PLP-dependent ω-transaminases and
L5-1 cofactor for flow-biocatalysis
Martina Letizia Contente (Nottingham/GB), Francesca Paradisi
Fernando López-Gallego (Nottingham/GB; Zaragoza/ES)
Ana I. Benítez-Mateos (San Sebastián/ES)
11:20 Flexible bio-production based on Cupriavidus necator – heterotrophic,
L5-2 autotrophic and eletrotrophic production of terpenoids
Dirk Holtmann (Frankfurt am Main/DE)
14ProgrammeGeneral
l tuesday,
Information
28 august
11:40 From hit to process – examples of chiral amine synthesis from small to
L5-3 large scale
Serena Bisagni, Ahir Pushpanath, Annette Alcasabas, Amin Bornadel
Iustina Slabu, David Woodlock, Chloe Fisher
Beatriz Dominguez (Cambridge/GB)
12:00 OrganoCat – biogenic lignocellulose fractionation for biorefineries
L5-4 Pablo Dominguez de Maria (Las Palmas de Gran Canaria/ES)
Philipp Grande (Jülich/DE), Holger Klose (Jülich, Aachen/DE)
Walter Leitner (Mülheim an der Ruhr, Aachen/DE)
Ulrich Schurr (Jülich/DE), Björn Usadel (Jülich, Aachen/DE)
12:20 Industrial application of RedAms for biocatalytic reductive amination
L5-5 Markus Schober (Stevenage/GB)
12:40–14:00 Lunch at Mensa
14:00–15:30 POSTER SESSION 2 – TOPIC 1 (see page 35)
Enzyme discovery, production and application – P1-1–P1-63
14:00–15:00 LIGHTNING TALK SESSION 2 – TOPIC 1
Audimax I Enzyme discovery, production and application
Chair Selin Kara (Hamburg/DE)
P1-1 RosB is an 8-amino-8-demethyl-riboflavin-5’-phosphate synthase and
the first member of a novel class of enzymes which are oxidoreductases,
decarboxylases and aminotransferases in one
Matthias Mack (Mannheim/DE)
P1-2 Acceleration of enzymatic degradation of poly(ethylene terephthalate)
by coating its surface with anionic surfactants
Makoto Furukawa, Norifumi Kawakami, Kenji Miyamoto (Yokohama/JP)
P1-3 New laccases from Fusarium oxysporum
Natalia Kwiatos, Marzena Jędrzejczak-Krzepkowska
Stanisław Bielecki (Łódź/PL)
P1-4 Continuous protein hydrolysis for the production of bioactive peptides
Tim Sewczyk (Hannover/DE), Marieke Hoog Antink
Michael Maas (Bremen/DE), Sascha Beutel (Hannover/DE)
P1-5 Rational identification of aggregation hotspots based on secondary
structure and amino acid hydrophobicity
Daisuke Matsui, Shogo Nakano, Yasuhisa Asano (Imizu/JP)
26–30 August 2018
Hamburg University of Technology l Germany 15General Information
Programme l tuesday, 28 august
P1-6 Biocatalytic potential of the epoxide hydrolase (YlEH) from a tropical
marine yeast Yarrowia lipolytica NCIM 3589
Vijaya Godase (Pune, Kolhapur/IN), Ameeta Ravikumar (Pune/IN)
P1-7 Exploration of biocatalysts diversity by integrating bioinformatics with
biochemical testing
Pavel Vanacek, Eva Sebestova, Petra Babkova, Sarka Bidmanova
Lukas Daniel, Pavel Dvorak, Veronika Stepankova, Radka Chaloupkova
Jan Brezovsky, Jiri Damborsky, Zbynek Prokop (Brno/CZ)
P1-8 New strategy for the discovery of carbohydrate-active enzymes through
integrated omics
Philip Busch, Marcel Suleiman, Christian Schäfers
Garabed Antranikian (Hamburg/DE)
P1-9 Influence of recalcitrant substrates on microbial diversity of samples
from Azorean hot springs
Marcel Suleiman, Barbara Klippel, Philip Busch, Christian Schäfers
Garabed Antranikian (Hamburg/DE)
P1-10 News from vanillyl alcohol oxidase
Gudrun Gygli (Stuttgart/DE; Wageningen/NL), Tom A. Ewing
Willem J. H. van Berkel (Wageningen/NL)
P1-11 The monolignol oxidoreductase AtBBE-like protein 15 – characterization,
rational engineering and biocatalytic applications
Bastian Daniel, Sabine Pils, Peter Macheroux, Jörg H. Schrittwieser
Wolfgang Kroutil (Graz/AT)
P1-12 Stereoselective conversion of α-angelica lactone to (R)-γ-valerolactone
in a one-pot two-step enzymatic cascade
Marina Simona Robescu, Laura Cendron (Padova/IT)
Riccardo Motterle (Montecchio Maggiore/IT)
Elisabetta Bergantino (Padova/IT), Mélanie Hall (Graz/AT)
P1-13 Aggregating flavoprotein as a catalyst for 1-dehydro-3-ketosteroids
production
Agnieszka M. Wojtkiewicz, Patrycja Wójcik, Monika Sroczyk
Maria Oszajca, Kamila Sofińska, Jakub Barbasz, Olga Zastawny
Maciej Guzik (Krakow/PL), Elvira Romero
Marco W. Fraaije (Groningen/NL), Maciej Szaleniec (Krakow/PL)
16ProgrammeGeneral
l tuesday,
Information
28 august
P1-14 Costa Rican lipases from native coffee plantation fungi as a green
alternative for the management of agroindustrial coffee by-products
Jorge Campos Rodríguez, Nicole Hernández Herrera
Daniela Pereira Arce, Elias Quesada Carrillo, Randall Syedd León
Frank Solano Campos, Luis Roberto Villegas-Peñaranda
Manuel Sandoval Barrantes (Heredia/CR)
P1-15 Laccase production from hazelnut husk via submerged cultivation of
white-rot fungi
Zeynep Yilmaz Sercinoglu, Nihat Alpagu Sayar (Istanbul/TR)
P1-16 A novel biocatalyst for the biotransformation of Taxanes/Taxol®
Eugen Schell, Marion Ansorge-Schumacher (Dresden/DE)
15:30–15:50 Coffee break and industrial exhibition
15:50–16:50 INDUSTRIAL IMPLEMENTATIONS – AFTERNOON SESSION 2 – TOPIC 1
Audimax I Enzyme discovery, production and application
Chair Gregg Beckham (Golden, CO/US)
15:50 MetaFluidics – ultra-high throughput metagenomic enzyme discovery
L1-6 Michael Roggenbuck, Keith McCall, Martin S. Borchert (Bagsvaerd/DK)
16:10 Mining and engineering of novel redox enzymes from genomic and
L1-7 metagenomic libraries for the biocatalytic conversion of lignin and
lignocellulosic biomass
Giang-Son Nguyen (Trondheim/NO), Noelia Villarroel Rodriguez
Narcis Fernandez-Fuentes, Joe Gallagher (Aberystwyth/GB)
Anna S. Lewin, Geir Klinkenberg, Håvard Sletta
Trond E. Ellingsen (Trondheim/NO), Eva Kranen
Ruth Maas (Düsseldorf/DE), Vincent G. H. Eijsink (Ås/NO)
Alexander Wentzel (Trondheim/NO)
16:30 EziGTM-immobilised biocatalysts – applications in organic solvents and
L1-8 continuous flow
Matthew Thompson (Stockholm/SE)
17:00–22:30 CONGRESS DINNER ON THE BOAT LOUISIANA STAR
biocat award ceremony (see page 56)
26–30 August 2018
Hamburg University of Technology l Germany 17General Information
Programme l Wednesday, 29 august
09:00–11:00 INVITED SPEAKER SESSION 3 – TOPIC 1
Audimax I Enzyme discovery, production and application
Chair Tom Desmet (Gent/BE)
09:00 Substrate specificity of tRNA-dependent amide bond-forming enzyme
IL1-1 Yoshimitsu Hamano (Fukui/JP)
09:30 New tools facilitating discovery, expression, engineering and application
IL1-2 of enzymes from eukaryotes
Anton Glieder (Graz/AT)
10:00 Engineering a GH89 α-N-acetylglucosaminidase in an α-thioglycoligase
IL1-3 for the chemoenzymatic synthesis of α-N-glycoconjugates
A. Strazzulli (Naples/IT), N.O. Tshililo (Matieland/ZA)
B. Cobucci-Ponzano, R. Iacono, L. Maurelli, E. Bedini
M.M. Corsaro (Naples/IT), E. Strauss (Matieland/ZA)
Marco Moracci (Naples/IT)
10:30 Use of L-amino acid deaminase in one-step or multi-step biocatalysis
IL2-5 Loredano Pollegioni, Roberta Melis, Elena Rosini, Valentina Pirillo
Antonio Savinelli, Paolo Motta, Gianluca Molla (Varese/IT)
11:00–11:30 Coffee break and industrial exhibition
11:30–13:20 MORNING SESSION 3 – TOPICS 5+2 (PARALLEL SESSION)
Audimax I Sustainable industrial processes, biorefinery and bioeconomy +
Structure-function analysis and enzyme design
Chair Marco W. Fraaije (Groningen/NL)
11:30 Greek bioeconomy – current status, initiatives and perspectives
IL5-1 Constantinos E. Vorgias (Athens/GR)
12:00 Thermotolerant biotechnology – biocatalysts for added manufacturing
L2-1 Kersten Rabe (Eggenstein-Leopoldshafen/DE)
12:20 Data-integrated simulation of enzymes
L2-2 Jürgen Pleiss (Stuttgart/DE)
12:40 A novel (R)-selective amine transaminase with extraordinary substrate
L2-3 scope
Aline Telzerow (Graz/AT), Maria Håkansson (Lund/SE)
Juraj Paris (Bielefeld/DE), Martin Schuermann (Geleen/NL)
Javier Sabin (Oviedo/ES), Helmut Schwab, Kerstin Steiner (Graz/AT)
18Programme l Wednesday,
General Information
29 august
13:00 Computational design of enzyme catalyst on new scaffolds for the
L2-4 synthesis of cephalosporin antibiotics
Yushan Zhu (Beijing/CN)
11:30–13:20 MORNING SESSION 4 – TOPICS 2+3 (PARALLEL SESSION)
Ditze Lecture Hall Structure-function analysis and enzyme design + Enzymatic and whole
cell biotransformations
Chair Bettina Nestl (Stuttgart/DE)
11:30 Simple standardisation of MD and QM protocols to derive highly active
L2-8 lipases at low pH optima and enantiospecific keto reductases
Rithvik Vinekar, Akshai Shreenivasan, Naveen Krishna, Kiran Takur
Shivakumar Venkataraju, Naveen Kulkarni
R. Pravin Kumar (Bangalore/IN)
12:00 Amano’s biotransformarion enzymes for chiral synthesis
L2-9 Yukihide Sato (Oxfordshire/GB)
12:20 H2-driven cofactor regeneration in a recombinant Pseudomonas putida
L3-1 strain for production of 1-octanol
Lars Lauterbach, Tom Lonsdale (Berlin/DE), Sumire Honda Malca
Bettina Nestl, Bernhard Hauer (Stuttgart/DE), Oliver Lenz (Berlin/DE)
12:40 Enantioselective synthesis of the key intermediate of suvorexant via
L3-2 enzymatic intramolecular asymmetric reductive amination
Zefei Xu, Peiyuan Yao, Shanshan Yu, Qiaqing Wu, Dunming Zhu
Xuerong Xing (Tianjin/CN)
13:00 Light-driven enzymatic decarboxylation of free fatty acids
L3-3 Mieke Huijbers, Wuyuan Zhang, Frank Hollmann (Delft/NL)
13:20–14:40 Lunch at Mensa
14:40–16:40 POSTER SESSION 3 – TOPICS 2+4+5 (see page 43)
Structure-function analysis and enzyme design – P2-1–P2-43
Bioprocess engineering and downstream processing – P4-1–P4-24
Sustainable industrial processes, biorefinery and bioeconomy – P5-1–P5-17
14:40–15:50 LIGHTNING TALK SESSION 3 – TOPICS 2+4+5
Audimax I Structure-function analysis and enzyme design
Chair Andreas Liese (Hamburg/DE)
P2-1 Understanding enzyme interactions under process conditions
Valerio Ferrario, Jürgen Pleiss (Stuttgart/DE)
26–30 August 2018
Hamburg University of Technology l Germany 19General Information
Programme l Wednesday, 29 august
P2-2 In vitro activity of piromyces xylose isomerase and its in vivo
performance in yeast
Misun Lee, Henriëtte Rozeboom (Groningen/NL), Maarten Verhoeven
Paul de Waal, Jack Pronk (Delft/NL), Dick B. Janssen (Groningen/NL)
P2-3 Structure-based engineering of steroidogenic CYP260A1 for stereo- and
regioselective hydroxylation of progesterone
Yogan Khatri (Saarbrücken/DE; Ann Arbor, MI/US)
Ilona Jóźwik (Groningen/NL), Michael Ringle, Irina Ionescu
Martin Litzenburger, Michael Hutter (Saarbrücken/DE)
Andy Thunnissen (Groningen/NL), Rita Bernhardt (Saarbrücken/DE)
P2-4 Novel insights into β-etherase catalysis
Jana Husarcikova, Hauke Voß, Anett Schallmey (Braunschweig/DE)
P2-5 Combinatorial engineering of proteolytically resistant APPI variants that
selectively inhibit human mesotrypsin for cancer therapy
Niv Papo (Beer Sheva/IL)
P2-6 Dynamics of sub-unit assembly within multi enzyme complex and its
mutants
Sibel Ilhan, Uwe Jandt, Cornelius Müller (Hamburg/DE)
P2-7 Design and evaluation of metal-binding sites in a new engineered
protein scaffold for achieving artificial metalloenzymes
Dominik Renn, Johannes Fischer (Thuwal/SA; Garching/DE)
Felix Quitterer (Garching/DE), Anand Radhakrishnan, Meina Liu
Magnus A. Rueping, Stefan T. Arold (Thuwal/SA)
Michael Groll (Garching/DE), Jörg Eppinger (Thuwal/SA)
P2-8 Engineering enzymes for the fabrication of robust and highly active
heterogeneous biocatalyst
Andoni Rodriguez-Abetxuko, Ana Beloqui (Donostia-San Sebastián/ES)
P2-9 Engineering of phosphoserine aminotransferase for a novel biosynthetic
pathway of 1,3-propanediol from glucose via homoserine
Yujun Zhang, Chengwei Ma (Hamburg/DE)
Wanda Dischert (Clermont-Ferrand/FR), An-Ping Zeng (Hamburg/DE)
20Programme l Wednesday,
General Information
29 august
Bioprocess engineering and downstream processing
P4-1 Development of an in situ-product crystallization (ISPC)-concept to shift
the reaction equilibria of selected transaminase-catalyzed reactions
Dennis Hülsewede (Rostock/DE), Philipp Süss
Ulf Menyes (Greifswald/DE), Jan von Langermann (Rostock/DE)
P4-2 Rational strategy for nuclease immobilisation on synthetic resins
Simona Serban, Alessandra Basso (Llantrisant/GB), Valerio Ferrario
Juergen Pleiss (Stuttgart/DE), Benjamin Summers (Llantrisant/GB)
P4-3 Impact of yeast extract on amino acid de novo synthesis and
glycosylation of recombinant proteins
Jan Förster, Lars Blank (Aachen/DE), Katelijne Bekers (Hamburg/DE)
P4-4 Chiral amines synthesis and in situ product recovery for process
intensification for application in organic fine chemicals and
pharmaceuticals
Claudia Matassa (Mol/BE; Greifswald/DE), Matthias Höhne (Greifswald/DE)
Dominic Ormerod, Yamini Satyawali (Mol/BE)
P4-5 Improvement of bioreactor performance using immobilized lipase in
supercritical carbon dioxide for development of lipid modification process
Masakazu Naya, Atsushi Shono (Tokyo/JP)
Masanao Imai (Kanagawa-pref./JP)
P4-6 Development and scale-up of efficient biocatalytic oxidations using
oxygen
Jan Brummund, Catharina Kleist, Harrie Straatman, Martin Schürmann
Monika Müller (Geleen/NL)
P4-7 In situ monitoring of the biocatalyzed (S)-naproxen synthesis with
process raman spectroscopy
Anne Stöbener, Tim Ramelow, Miriam Assmann
Selin Kara (Hamburg/DE), Hanns Simon Eckhardt (Oberursel/DE)
Andreas Liese (Hamburg/DE)
Sustainable industrial processes, biorefinery and bioeconomy
P5-1 Development of a chemo-enzymatic route for the synthesis of chiral
vicinal amino alcohols-application for the synthesis of ethambutol,
an anti-tuberculosis drug
Yudhisthir Mandal, K.K Balasubramanian, Anju Chadha (Tamil Nadu/IN)
26–30 August 2018
Hamburg University of Technology l Germany 21General Information
Programme l Wednesday, 29 august
P5-2 Bioelectrochemical NADPH regeneration using biocatalysis in redox
hydrogel matrices
Leonardo Castañeda Losada, Carolina Laverde Perdomo
Michael Richter, Nicolas Plumeré (Straubing/DE)
P5-3 Lurgi process-based fatty alcohol synthesis via a chemoenzymatic
reaction sequence
Kim Schlipköter, Andreas Liese, Joscha Kleber
Anne Stöbener (Hamburg/DE), Harald Gröger
Tobias Betke (Bielefeld/DE)
P5-4 Biorefinery of australian rock lobster shells (Jasus edwardsii) by
microwave intensified enzymatic deproteinization and demineralization
for production of multiple functional food ingredients
Wei Zhang, Trung Nguyen (Adelaide/AU)
P5-5 Micropollutant degradation in enzymatic membrane bioreactor (EMBR)
Faisal Hai, Muhammad Bilal Asif (Wollongong/AU)
16:40–17:00 Coffee break and industrial exhibition
17:00–18:00 AFTERNOON SESSION 3 – TOPIC 3 (PARALLEL SESSION)
Audimax I Enzymatic and whole cell biotransformations
Chair An-Ping Zeng (Hamburg/DE)
17:00 Chemo-enzymatic cascade synthesis of optically pure alkanoic acids
L3-4 using engineered arylmalonate decarboxylase variants
Junichi Enoki, Carolin Mügge (Bochum/DE)
Kenji Miyamoto (Yokohama/JP), Robert Kourist (Bochum/DE; Graz/AT)
17:20 Development of a modular whole cell glycosylation platform for small
L3-5 molecules
Constantin Ruprecht, Friedericke Bönisch, Wolfgang R. Streit
Ulrich Rabausch (Hamburg/DE)
17:40 Biocatalytic asymmetric synthesis of N-functionalized L-aspartic acids
L3-6 Jielin Zhang, Haigen Fu, Pieter G. Tepper
Gerrit J. Poelarends (Groningen/NL)
2217:00–18:00 AFTERNOON SESSION 4 – TOPIC 2 (PARALLEL SESSION)
Ditze Lecture Hall Structure-function analysis and enzyme design
Chair Mosè Rossi (Napoli/IT)
17:00 Loop swapping as protein engineering approach to optimise
L2-5 NADH-binding of ene reductases
Christoph Mähler, Dirk Weuster-Botz (Garching/DE)
Kathrin Castiglione (Erlangen/DE)
17:20 Enhancement of lipase selectivity by semi-rational design
L2-6 Katja Zorn, Isabel Oroz-Guinea, Henrike Brundiek
Uwe T. Bornscheuer (Greifswald/DE)
17:40 The many roads to Rome – How to overcome limitations for the
L2-7 production of chiral β-amino acids via ω-transaminases (ω-TAs)
Jens Rudat, Oliver Buß (Karlsruhe/DE)
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Programme l Thursday, 30 august
08:30–10:30 INVITED SPEAKER SESSION 4 – TOPIC 3+4
Audimax I Enzymatic and whole cell biotransformations + Bioprocess engineering
and downstream processing
Chair Joe Adams (Stevenage/GB)
08:30 Enzyme design in synthetic biology – a key role from proof-of-concept
IL3-5 towards precision function
Yan Feng (Shanghai/CN)
09:00 Complex N-acetylhexosamines prepared by engineered enzymes for
IL3-6 targeting lectins
Pavla Bojarová (Praha/CZ), Dominic Laaf (Aachen/DE), Petr Chytil
Tomáš Etrych (Praha/CZ), Lothar Elling (Aachen/DE)
Vladimír Křen (Praha/CZ)
09:30 Computer-aided engineering of enzymes for in vitro and in vivo
IL4-1 production of novel precursors
Isabelle André (Toulouse/FR)
10:00 The Nestlé culture collection – from gene to activity
IL4-2 Christoph Bolten (Lausanne/CH)
10:30–11:00 Coffee break and industrial exhibition
11:00–13:00 INDUSTRIAL IMPLEMENTATIONS – MORNING SESSION 5 – TOPIC 3
Audimax I Enzymatic and whole cell biotransformations
Chair Andreas Liese (Hamburg/DE)
11:00 Glycosynthases – a biocatalytic approach to the synthesis of glycosides
L3-7 Marc Hayes (Düsseldorf/DE), Jörg Pietruszka (Düsseldorf, Jülich/DE)
11:20 Selective ring-opening of di-substituted epoxides by halohydrin
L3-8 dehalogenases
Anett Schallmey, Elia Calderini, Julia Koopmeiners (Braunschweig/DE)
11:40 H2-driven heterogeneous biocatalysis for the atom-efficient synthesis of
L3-9 α‑chiral amines
Jack Rowbotham, Lisa Thompson, Barnabas Poznansky, Xu Zhao
Jake Nicholson, Holly Reeve, Kylie Vincent (Oxford/GB)
24Programme General
l Thursday,
Information
30 august
12:00 Smart engineering of aldolases for asymmetric synthesis of
L3-10 β-hydroxyl-α-amino acids on industrial scale
Marco Bocola, Haibin Chen (Ningbo/CN)
Thomas Daußmann (Ningbo/CN; Düsseldorf/DE)
Yong Koy Bong (Ningbo/CN)
12:20 Suppression of by-product hydroxyproline generation in the growth
L3-11 coupled production of hydroxypipecolic acid by recombinant
microorganisms
Ryoma Miyake, Takanobu Iura, Kenji Oki, Yuriko Iwano
Haruka Sasano (Yokohama/JP), Hiroshi Kawabata (Yokohama, Tokyo/JP)
12:40 Industrial synthesis of functional ingredients by enzyme cascade
L3-12 reactions
Andreas Vogel (Leipzig/DE)
13:00–13:30 CLOSING REMARKS
Audimax I Poster awards (see page 59)
26–30 August 2018
Hamburg University of Technology l Germany 25Generall Information
Poster monday, 27 august
14:30–16:30 POSTER SESSION 1 – TOPIC 3
Room H0.01–H0.09 Enzymatic and whole cell biotransformations
P3-1 Finally – diterminal oxidation of medium chain alkanes
Youri van Nuland, Gerrit Eggink, Ruud Weusthuis (Wageningen/NL)
P3-2 Aldol additions of pyruvate analogs to formaldehyde – synthesis of
optically active β-hydroxycarboxylic esters
Pere Clapes, Karel Hernández, Jordi Bujons, Jesús Joglar
Roser Marín (Barcelona/ES)
P3-3 Biosynthesis of N-heterocycles from diamine at the expense of
molecular oxygen and molecular hydrogen
Ammar Al-Shameri (Berlin/DE), Niels Borlinghaus
Bettina Nestl (Stuttgart/DE), Lars Lauterbach (Berlin/DE)
P3-4 Compartmentalized aqueous-organic emulsions for efficient biocatalysis
Changzhu Wu (Odense M/DK)
P3-5 Accessing enantiopure epoxides and sulfoxides via group E
monooxygenases
Thomas Heine, Anika Scholtissek, Lucas Siegel, Sarah Hofmann
Xiaoqi Gao, Philipp Rathsack (Freiberg/DE)
Dirk Tischler (Freiberg, Bochum/DE)
P3-6 Selective aerobic oxidation of C-H bonds by combining photochemistry
and biocatalysis
Wuyuan Zhang, Elena Fernández-Fueyo, Yan Ni, Morten van Schie
Jenö Gacs, Bastien O. Burek, Jonathan Z. Bloh, Rokus Renirie
Ron Wever, Francesco G. Mutti, Dörte Rother, Miguel Alcalde
Frank Hollmann (Delft/NL)
P3-7 Whole cell biocatalyst expressing a surface-displayed P450 allows for
efficient hydroxylation reactions
Marcus Probst, Cindy Kunze (Frankfurt am Main/DE), Eva Kranen
Ruth Maas (Düsseldorf/DE), Dirk Holtmann (Frankfurt am Main/DE)
P3-8 Ionization basis for activation of enzymes in zwitterionic liquids
Guangnan Ou, Biyan He (Xiamen/CN)
26PosterGeneral
l monday,
Information
27 august
P3-9 Model optimization of DERA-catalyzed double aldol addition
Ana Vrsalović Presečki, Anera Švarc, Đurđa Vasić-Rački (Zagreb/HR)
Karel Hernandez, Pere Clapés (Barcelona/ES)
Zvjezdana Findrik Blažević (Zagreb/HR)
P3-10 Enzyme catalysed synthesis of esters in water
Ulf Hanefeld (Delft/NL)
P3-11 New bioactive prodigiosin derivatives – a bridge between chemistry and
biology
Hannah U. C. Braß, Andreas S. Klein, Thomas Classen, Anita Loeschcke
Thomas Drepper (Jülich/DE), Sonja Sievers (Dortmund/DE)
Karl-Erich Jaeger, Jörg Pietruszka (Jülich/DE)
P3-12 Enrichment of mono-unsaturated long chain fatty acids from camelina
and crambe seed oils by engineered lipase variants
Isabel Oroz-Guinea, Katja Zorn, Henrike Brundiek
Uwe T. Bornscheuer (Greifswald/DE)
P3-13 Catalytic properties of the fluoroketone reductase from Pichia farinosa
NBRC0462
Sayaka Kamai, Sayaka Shichida (Imizu, Toyama/JP)
Shinsuke Miki (Kawagoe/JP), Kimiyasu Isobe, Makoto Hibi
Yasuhisa Asano (Imizu, Toyama/JP)
P3-14 Microbial electrosynthesis of chiral alcohols using resting recombinant
Escherichia coli cells
Jeannine Mayr (Braunschweig/DE), Luis F. M. Rosa (Leipzig/DE)
Jan-Hendrik Grosch (Braunschweig/DE), Falk Harnisch (Leipzig/DE)
Antje C. Spiess (Braunschweig/DE)
P3-15 Stereoselective one-pot enzyme cascade towards
γ‑Butyrolactone fragrances
Ceyda Kumru, Thomas Classen, Jörg Pietruszka (Jülich/DE)
P3-16 Synthesis of syringaresinol from 2,6-dimethoxy-4-allylphenol using an
oxidase/peroxidase enzyme system
Mohamed Habib (Groningen/NL, Cairo/EG), Milos Trajkovic
Marco W. Fraaije (Groningen/NL)
P3-17 Biocatalysis alternatives dedicated to flavors and fragrances production
Madalina Tudorache, Sabina Ion, Cristina Sora, Simona Reznicencu
Vasile Parvulescu (Bucharest/RO)
26–30 August 2018
Hamburg University of Technology l Germany 27Generall Information
Poster monday, 27 august
P3-18 Aromatic hydroxylases as part of enzymatic cascading reactions
Martin Dippe, Susann Hermann, Benjamin Weigel
Ludger Wessjohann (Halle an der Saale/DE)
P3-19 Biotransformation of unnatural substrates by sesquiterpene cyclases
Vanessa Harms, Clara Oberhauser, Katja Seidel
Andreas Kirschning (Hannover/DE)
P3-20 A light-driven enzyme cascade reaction for the synthesis of lactones
Hanna Christiane Büchsenschütz (Graz/AT)
Fabian Schultes (Bochum/DE), Sandy Schmidt, Robert Kourist (Graz/AT)
P3-21 Reaction mechanisms, product selectivity and characterization of the
recombinant SUMO (+)-zizaene synthase from Vetiveria zizanioides
Francisco Aguilar, Stephan Hartwig, Thomas Scheper
Sascha Beutel (Hannover/DE)
P3-22 Sialylated human milk oligosaccharides produced in optimized
enzymatic one-pot reactions
Sabine Schelch, Barbara Petschacher, Stefanie Gross Belduma
Manuel Eibinger (Graz/AT), Uma Reddy, Jürgen Kuballa (Hamburg/DE)
Bernd Nidetzky (Graz/AT)
P3-23 Growth of Gulf of Mexico Rhodococcus erythropolis PC20 strain under
the influence of pressure and dispersant
Steffen Hackbusch, Juan Viamonte, Nuttapol Noirungsee (Hamburg/DE)
Xiaoxu Sun (Atlanta, GA/US), Paul Bubenheim (Hamburg/DE)
Joel Kostka (Atlanta, GA/US), Andreas Liese (Hamburg/DE)
P3-24 Multienzymatic cascade reactions in a 2-phase system
Jens Johannsen, Claudia Engelmann, Andreas Liese, Georg Fieg
Paul Bubenheim, Thomas Waluga (Hamburg/DE)
P3-25 Enzymatic synthesis of glycerol ethers derivatives as new green solvents
Susana Velasco-Lozano, Alejandro Leal-Duaso, Elisabeth Pires
José Ignacio García, José Antonio Mayoral
Fernando López-Gallego (Zaragoza/ES)
P3-26 Peroxygenases – dream catalysts for selective oxyfunctionalization
reactions?
Florian Tieves (Delft/NL), Patricia Gómez de Santos
Elena Fernández-Fueyo, Miguel Alcalde (Madrid/ES)
Frank Hollmann (Delft/NL)
28PosterGeneral
l monday,
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27 august
P3-27 Photobiocatalytic routes towards chiral amines
Christoph K. Winkler, Silvan Poschenrieder, Valentina Jurkaš
Sandy Schmidt, Hanna C. Büchsenschütz, Viktorija Vidimce
Robert Kourist, Wolfgang Kroutil (Graz/AT)
P3-28 One-pot multi-enzyme synthesis of UDP-Man
Reza Mahour (Magdeburg/DE)
Cláudia Filipa Duarte Bento (Magdeburg/DE; Caparica/PT)
Thomas F. T. Rexer, Udo Reichl (Magdeburg/DE)
P3-29 Evolving transaminases towards sugar substrates
Ryan Cairns (Nottingham/GB), Moritz Voss
Uwe T. Bornscheuer (Greifswald/DE), Elaine O’Reilly (Nottingham/GB)
P3-30 Development of E. coli based whole cell biocatalysts for
plant P450 monooxygenases
Stefan Wohlgemuth, Esther Ricklefs, Sarah Kranz-Finger
Vlada B. Urlacher (Düsseldorf/DE)
P3-31 Mathematical modeling of DERA-catalyzed statin side-chain
intermediate production
Anera Švarc, Đurđa Vasić-Rački, Zvjezdana Findrik Blažević (Zagreb/HR)
Karel Hernandez, Pere Clapés (Barcelona/ES)
Ana Vrsalović Presečki (Zagreb/HR)
P3-32 Hetero-and autotrophically driven biotransformations in C. necator
Leen Assil Companioni, Sandy Schmidt, Petra Heidinger, Helmut Schwab
Robert Kourist (Graz/AT)
P3-33 Selective biocatalytic synthesis of nordihydroguaiaretic acid (NDGA)
glucosides and analysis of their chemical, physical and pharmacological
properties
Johannes Nolte, Lara-Alina Pöttgen, Alexander Kempa, Julia Sperlich
Ulrich Schörken (Leverkusen/DE)
P3-34 Avoiding cross-reactivities in multi-step biocatalysis by light‑induced
enzyme deactivation
Tim Gerlach, Fabienne Hilgers, Nora Bitzenhofer, Thomas Drepper
Dörte Rother (Jülich/DE)
26–30 August 2018
Hamburg University of Technology l Germany 29Generall Information
Poster monday, 27 august
P3-35 High-yield production of cortisone by establishment of an efficient
whole-cell system in Bacillus megaterium
Lisa König, Philip Hartz, Rita Bernhardt
Frank Hannemann (Saarbrücken/DE)
P3-36 Site-specific covalent immobilization of a recombinant fungal
L-amino acid oxidase for efficient production of alpha-keto acids
Tobias Beuel, Svenja Bloess, Karthikeyan Radhakrishnan
Gabriele Fischer von Mollard, Thomas Dierks (Bielefeld/DE)
P3-37 Enzymatic tandem approach to Knoevenagel condensation of enol
acetates with aldehydes in organic media
Dominik Koszelewski, Ryszard Ostaszewski (Warsaw/PL)
P3-38 Chemoenzymatic tandem reaction promoted by sugar esters for the
synthesis of α-acyloxy carboxamides containing coumarin scaffold
Daniel Paprocki, Ryszard Ostaszewski (Warsaw/PL)
P3-39 Fusion enzyme of FMO-E and HLADH for a convergent cascade reaction
in non-conventional media
Lei Huang (Hamburg/DE), Friso S. Aalbers (Groningen/NL)
Wei Tang (Hamburg/DE), Marco W. Fraaije (Groningen/NL)
Selin Kara (Hamburg/DE)
P3-40 Asymmetric enzymatic synthesis of the metallo-β-lactamase inhibitor
aspergillomarasmine A and related aminocarboxylic acids
Haigen Fu, Jielin Zhang, Mohammad Saifuddin, Gea Cruiming
Pieter Tepper, Gerrit Poelarends (Groningen/NL)
P3-41 Lipase from porcine pancreas – efficient biocatalyst for the synthesis of
ortho-aminocarbonitriles
Kiran Dalal, Dipak Dalal, Bhushan Chaudhari (Jalgaon/IN)
P3-42 Characterisation of Baeyer-Villiger monooxygenases and optimisation of
the convergent cascade for synthesis of Epsilon-Caprolactone
Jennifer Engel (Hamburg/DE), Katlego Mthethwa
Dirk Opperman (Bloemfontein/ZA), Selin Kara (Hamburg/DE)
P3-43 Potential of carbon dioxide fine bubbles in biocatalysis
Daniel Ohde, Benjamin Thomas, Simon Matthes
Paul Bubenheim (Hamburg/DE), Koichi Terasaka (Tokio/DE)
Michael Schlüter, Andreas Liese (Hamburg/DE)
30PosterGeneral
l monday,
Information
27 august
P3-44 Enzymatic kinetic resolution of enol lactones as a new approach towards
chiral peptidomimetics
Anna Brodzka, Ryszard Ostaszewski (Warsaw/PL)
P3-45 Structural and physicochemical characterization of sophorolipids from
Starmerella bombicola and Candida kuoi
Christian Zerhusen, Yifei Zhan, Timo Bollmann, Sonja Müller
Birgit Glüsen, Ulrich Schörken (Leverkusen/DE)
P3-46 Probing enzyme active sites in promiscious ugi reaction by isocyanates
Monika Wilk, Damian Trzepizur, Ryszard Ostaszewski (Warsaw/PL)
P3-47 Independent cell transamination
Stylianos Grigoriou, Frederik Walter, Evelina Kulcinskaja, John King
Phil Hill, Elaine O’Reilly (Nottingham/GB)
P3-48 A novel assay for the detection of carboxylic acid reductase (CAR)
activity in whole cells
Daniel Schwendenwein (Graz/AT), Anna Ressmann
Florian Rudroff (Vienna/AT), Margit Winkler (Graz/AT)
P3-49 (R,R)-Butane-2,3-diol dehydrogenase from Bacillus clausii DSM 8716T –
a versatile biocatalyst for synthesis of α-hydroxy ketones/diols and
biosensor development
Lukas Muschallik, Denise Molinnus, Melanie Jablonski, Carina Kipp
Johannes Bongaerts, Torsten Wagner, Martina Pohl, Thorsten Selmer
Michael J. Schöning, Petra Siegert (Jülich/DE)
P3-50 Fine bubbles for biochemical transformation
Benjamin Thomas, Daniel Ohde, Simon Matthes
Paul Bubenheim (Hamburg/DE), Koichi Terasaka (Tokyo/JP)
Michael Schlüter, Andreas Liese (Hamburg/DE)
P3-51 Screening for hydrolases catalyzing the esterification of cyclic (di-)
carboxylic acids
Robert Hiessl, Yvonne Schade (Hamburg/DE)
Carmen Plass (Bielefeld/DE), Joscha Kleber (Hamburg/DE)
Rainer Otter (Ludwigshafen/DE), Harald Gröger (Bielefeld/DE)
Andreas Liese (Hamburg/DE)
26–30 August 2018
Hamburg University of Technology l Germany 31Generall Information
Poster monday, 27 august
P3-52 One-step process for production of N-methylated amino acids
Melanie Mindt (Bielefeld/DE), Hendrik Gruß (Biefeled/DE)
Joe Max Risse (Bielefeld/DE), Marcel Freese
Norbert Sewald (Biefeled/DE), Bernhard Eikmanns (Ulm/DE)
Volker Wendisch (Bielefeld/DE)
P3-53 Small laccase from Streptomyces coelicolor A3(2) – secretory expression
and application for the synthesis of antioxidants
Tukayi Kudanga, Deepti Yadav, Blessing Nemadziva
Nokuthula Mchunu (Durban/ZA), Marilize Le Roes-Hill (Cape Town/ZA)
P3-54 Large-scale production of oligocaprolactone in aqueous media
Vishnu S. T. Srinivasamurthy, Dominique Böttcher
Uwe T. Bornscheuer (Greifswald/DE)
P3-55 Production of milk oligosaccharide constituent sialic acid in
Saccharomyces cerevisiae
Uma Katha, Jürgen Kuballa (Hamburg/DE)
P3-56 Biocatalytic terpene platform
Antonino Biundo (Solna/SE), Arne Stamm (Stockholm/SE)
Maryam Mousa, Ylva Grevenfors (Solna/SE), Linda Fogelström
Eva Malmström (Stockholm/SE), Per-Olof Syrén (Solna/SE)
P3-57 Application of enzymatic dynamic kinetic resolution of homoallylic
alcohols to the synthesis of chiral δ-lactones
Filip Borys, Dominik Koszelewski, Ryszard Ostaszewski (Warsaw/PL)
P3-58 Stereospecific reductions of substituted β-keto-esters using microbial
whole-cell conversions and isolated microbial enzymes
Chris Drewniok, Katerina Barková, Akadil Belgara, Janine Heinrich
Philipp Röbisch, Corinna Schuster, Christian Trapp, Dieter Greif
Annett Fuchs, Marek Jan Pecyna, Thomas Wiegert (Zittau/DE)
P3-59 In vitro studies on cyclases from polyketide biosynthetic pathways for
the synthesis of heterocycles
Lisa Wagner, Tim Hollmann (Bayreuth/DE)
Gesche Berkhan (Hannover/DE), Frank Hahn (Bayreuth/DE)
P3-60 Characterization of fungal linoleate diol synthases with diverse
regio-specificities and biotransformation to hydroxy fatty acids using
recombinant cells expressing these enzymes
Min-Ju Seo, Kyung-Chul Shin, Deok-Kun Oh (Seoul/KR)
32PosterGeneral
l monday,
Information
27 august
P3-61 Biocatalytic oxidative cascade for the conversion of fatty acids to
α-Ketoacids via internal H2O2 recycling
Somayyeh Gandomkar, Alexander Dennig, Lucas Hammerer
Anđela Đordić, Mathias Pickl, Mélanie Hall, Wolfgang Kroutil
Kurt Faber (Graz/AT)
P3-62 Effect of elevated pressure on bacterial communities
Nuttapol Noirungsee, Steffen Hackbusch, Juan Viamonte
Paul Bubenheim, Rudolf Müller, Andreas Liese (Hamburg/DE)
P3-63 Synthesis of hops prenylflavonoids sulphates by Desulfitobacterium
hafniense aryl-sulfate sulfotransferase
Jarosław Popłoński, Sandra Sordon, Tomasz Tronina (Wrocław/PL)
Aloysius Hartog, Ron Wever (Amsterdam/NL)
Ewa Huszcza (Wrocław/PL)
P3-64 Cross-linked enzyme-adhered nanoparticles (CLEANs) and their
applications
Flóra Nagy, András Szilágyi, György T. Balogh, Diána Balogh-Weiser
László Poppe (Budapest/HU)
P3-65 Transformation of lactose to value-added products with immobilized
β-galactosidase
Helena Hronská, Silvia Michalíková, Michal Rosenberg (Bratislava/SK)
P3-66 Catalytic and substrate promiscuity of L-threonine aldolase
Kateryna Lypetska (Fesko) (Graz/AT)
P3-67 F420H2 dependent ene-reductases – revealing a new class of
enantioselective and regioselective biocatalysts
Milos Trajkovic, Sam Mathew, Hemant Kumar (Groningen/NL)
Quoc-Thai Nguyen (Ho Chi Minh City/VN)
Marco W. Fraaije (Groningen/NL)
P3-68 Kinetic resolution of amino acids by using covalently immobilized
lipase enzymes
Bianka Szokol, József Nagy (Budapest/HU)
László Poppe (Budapest/HU; Cluj-Napoca/RO)
P3-69 Biosynthesis of the Nylon 12 monomer, ω-aminododecanoic acid with
novel cytochrom P450, alcohol dehydrogenase, and
omega-transaminase enzymes
Hyunwoo Jeon, hyungdon Yun (Seoul/KR)
26–30 August 2018
Hamburg University of Technology l Germany 33Generall Information
Poster monday, 27 august
P3-70 The kinetic resolution of racemic amines using a whole-cell biocatalyst
co-expressing amine dehydrogenase and NADH oxidase
Sanghan Yoon, Hyunwoo Jeon, Hyungdon Yun (Seoul/KR)
P3-71 A highly effective and enantioselective Kurthia gibsonii SC0312 for the
asymmetric oxidation of racemic 1-phenyl-1,2-ethanediol
Wenyong Lou (Guangzhou/CN)
P3-72 Production of flavonoids with catechol moiety by rhodotorula genus
Sandra Sordon, Jarosław Popłoński, Magdalena Milczarek
Martyna Stachowicz, Tomasz Tronina, Joanna Wietrzyk
Ewa Huszcza (Wrocław/PL)
P3-73 Chemoenzymatic dynamic kinetic resolution of benzylic amines in fully
continuous-flow mode
Emese Farkas, Márk Oláh, Attila Földi (Budapest/HU)
Csaba Paizs (Cluj-Napoca/RO), Gábor Hornyánszky (Budapest/HU)
László Poppe (Budapest/HU; Cluj-Napoca/RO; Budapest/HU)
P3-74 Mutability-landscape guided enzyme engineering for improved
performance in aqueous-ethanol solvents
Chao Guo (Groningen/NL)
P3-75 Mimicking metabolism in the brain – analysis of cytochrome P450
mediated drug metabolism in iPS-derived cortical organoids
Nina Beyer, Matthias Vogel, Denna Tabari, Karim Barakat
Catharina Scholl, Julia Stingl (Bonn/DE)
P3-76 Orange peel-application/usage by an artificial enzymatic cascade
expressed in Pichia pastoris
Erna Zukic (Vienna/AT), Anton Glieder, Martina Geier (Graz/AT)
Nikolin Oberleitner, Anna Ressmann, K. Bica, P. Gärtner (Vienna/AT)
Marco W. Fraaije (Groningen/NL), Uwe T. Bornscheuer (Greifswald/DE)
Marko Mihovilovic, Florian Rudroff (Vienna/AT)
P3-77 Cell-free bio-conversion of n-octane to n-octanol via a bio-catalytic
approach
Shanna Swart, Athanasios Kotsiopoulos, Susan Harrison (Cape Town/ZA)
P3-78 Production of selenium nanoparticles in Pseudomonas putida KT2440
and identification of genes involved
Roberto Avendaño, Nefertiti Chaves, Paola Fuentes, Rafael Montenegro
Sofía Vieto, Ethel Sánchez (San José/CR), Jose I. Jiménez (Guildford/GB)
Max Chavarría (San José/CR)
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