Clinical Indications for Protein Use by Common Medical Condition
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MEDICAL QUALITY PROTEINTM
Clinical Indications for Protein Use
by Common Medical Condition:
A Resource for Healthcare Professionals
Research Based
www.unjury.com
For Professional Samples and Wholesale Information, Email: RD@UNJURY.com ©Copyright UNJURY Protein 2015
Disease State / Conditions Researched
- Weight Loss Surgeries - Malnutrition
- Weight Loss (Overweight and Obesity) - Wounds/decubitus ulcers/burns
MEDICAL QUALITY PROTEINTM - Diabetes - Vegetarians
- Pregnancy - HIV
- Lactation - PCOS
- Aging - Oncology
- Stroke - Dysphagia and Difficulties Chewing
- Cardiovascular Disease - Liver Disease
- Critical Care and Enteral Feedings - Inflammatory Bowel Disease
- Chyle Leaks - Eating Disorders
- COPD - Sports Nutrition
- Cystic Fibrosis
Weight Loss Surgeries
Advice to Patients Clinical Indications Research
Protein is a major priority Protein needs of bariatric surgery Mechanick JI, Kushner RF, Sugerman HJ, Gonzalez-Campoy M, Collazo-
following bariatric surgery. patients can range from 60 – 120 g Clavell ML, Guven S, Spitz AF, Apovian CM, Livingston EH, Brolin R,
per day. Sarwer DB, Anderson WA, Dixon J. American Association of Clinical
Endocrinologists, The Obesity Soceity, and American Society for
Protein deficiencies are common Metabolic & Bariatric Surgery medical guidelines for clinical practice for
Studies suggest that higher protein
after bariatric surgery, as many the perioperative nutritional, metabolic, and nonsurgical support of the
intakes (at least 80-90 g/day) are
patients struggle to get the associated with reduced loss of
bariatric patient. Surg Obes Relat Dis. 2008; 4: S109-S184.
amount of high quality protein lean body mass. Mechanick JI, Youdim A, Jones DB, Garvey WT, Hurley DL, McMahon
they need through foods or M, Heinberg LJ, Kushner R, Adams TD, Shikora S, Dixon JB, Brethauer S.
beverages alone. Clinical practice guidelines for the perioperative nutritional, metabolic,
and nonsurgical support of the bariatric surgery patient – 2013 update:
Unjury contains 21 g of high- cosponsored by American Association of Clinical Endocrinologist, The
Obesity Society, and American Society for Metabolic & Bariatric Surgery.
quality protein per serving to Surg Obes Relat Dis. 2013; 9: 159-191.
help patients meet their
elevated needs. Raftopoulos I, Bernstein B, O’Hara K, Ruby JA, Chhatrala R, Carty
J. Protein intake compliance of morbidly obese patients undergoing
bariatric surgery and its effect on weight loss and biochemical
Protein is not only important
parameters. Surg Obes Relat Dis. 2011; 7: 733-742.
immediately after surgery, but
in the long-term as well. Many Faria SL, Faria OP, Buffington C, de Almeida Cardeal M, Ito MK. Dietary
patients tend to regain weight protein intake and bariatric surgery patients: a review. Obes Surg. 2011;
when they stop using 21: 1798 – 1805.
protein supplements.
Information on protein needs
after weight loss surgery remains
somewhat limited and more
research is still needed. Aiming
for the higher end of current
recommendations gives patients
a good “insurance policy” and
helps ensure that if guidelines
eventually trend higher, their
protein needs have been met.
www.unjury.com
For Professional Samples and Wholesale Information, Email: RD@UNJURY.com ©Copyright UNJURY Protein 2015Weight Loss Surgeries (Continued)
Advice to Patients Clinical Indications Research
Unjury is a whey protein isolate For bariatric patients, supplemental, Mechanick JI, Kushner RF, Sugerman HJ, Gonzalez-Campoy M, Collazo-
that can be successfully used liquid protein supplements may be Clavell ML, Guven S, Spitz AF, Apovian CM, Livingston EH, Brolin R,
critical for achieving postoperative Sarwer DB, Anderson WA, Dixon J. American Association of Clinical
throughout diet advancement Endocrinologists, The Obesity Soceity, and American Society for
post-bariatric surgery. Unjury satiety, and preventing loss of lean
Metabolic & Bariatric Surgery medical guidelines for clinical practice for
body mass during rapid weight loss
can be mixed with clear liquids the perioperative nutritional, metabolic, and nonsurgical support of the
without adding unnecessary fat or
(Strawberry Sorbet, Chicken carbohydrate to the diet.
bariatric patient. Surg Obes Relat Dis. 2008; 4: S109-S184.
Soup, and Unflavored), full
Faria SL, Faria OP, Buffington C, de Almeida Cardeal M, Ito MK. Dietary
liquids (any flavor), and “The highest quality protein protein intake and bariatric surgery patients: a review. Obes Surg. 2011;
incorporated into a solid food products are made of whey 21: 1798 – 1805.
diet as well. protein, which provides high levels
of branched-chain amino acids
Unjury is well-tolerated (important to prevent lean tissue
postoperatively, easily absorbed, break down), remain soluble in the
and helps patients feel fuller, stomach, and are rapidly digested.”
longer, leading to better overall
diet compliance and improved
body composition.
Weight Loss (Overweight and Obesity)
Advice to Patients Clinical Indications Research
Whey protein helps promote Whey protein supplementation Baer DJ, Stote KS, Paul DR, Harris K, Rumpler WV, Clevidence BA. Whey
healthy weight loss. appears to play an important role protein but not soy protein supplementation alters body weight and
in dieting by promoting fat loss and composition in free-living overweight and obese adults. J Nutr. 2011;
141: 1489 - 1494.
Unjury is a whey protein isolate preserving lean body mass.
supplement that helps people Arciero PJ, Baur D, Connelly S, Ormsbee MJ. Timed-daily ingestion of
achieve healthy weight loss by whey protein and exercise training reduces visceral adipose tissue mass
and improves insulin resistance: the PRISE study. J Appl Physiol. 2014;
reducing unhealthy fat mass and
117: 1-10.
preserving important lean body
mass. Lean body mass is not only Pal S, Radavelli-Bagatini S. The effects of whey protein on
the muscles that we can see on our cardiometabolic risk factors. Obes Rev. 2013; 14: 324 – 343.
bodies, like our biceps or triceps,
but also important organs like our
heart and lungs.
One of the leading reasons diets Relative to casein, egg albumin, soy Anderson GH, Tecimer SN, Shah D, Zafar TA. Protein source, quantity,
fail is hunger. Unjury is a high- protein, and carbohydrate, whey and time of consumption determine the effect of proteins on short-term
protein consumption was found food intake in young men. J Nutr. 2004; 134: 3011 – 3015.
quality, whey protein isolate
that helps curb appetite, which to have greater subjective reports
Pal S, Radavelli-Bagatini, Hagger M, Ellis V. Comparative effects of whey
of satiety, delays in the return of
may lead to a reduction in and casein proteins on satiety in overweight and obese individuals: a
hunger, and can lead to greater
overall energy intake. suppression of food intake.
randomized controlled trial. Eur J Clin Nutr. 2014; 68: 980 – 986.
Faria SL, Faria OP, Buffington C, de Almeida Cardeal M, Ito MK. Dietary
Unjury also tastes great… protein intake and bariatric surgery patients: a review. Obes Surg. 2011;
Another factor that helps people 21: 1798 – 1805.
stick to their diets!
www.unjury.com
For Professional Samples and Wholesale Information, Email: RD@UNJURY.com ©Copyright UNJURY Protein 2015Diabetes
Advice to Patients Clinical Indications Research
Whey protein may improve Whey protein reduces spikes in Jing M, Stevens JE, Cukier K, Maddox AF, Wishart JM, Jones KL, Clifton
diabetes management. blood glucose following a meal PM, Horowitz M, Rayner, CK. Effects of a protein preload on gastric
and improves glucose regulation empting, glycemia, and gut hormones after a carbohydrate meal in diet-
Unjury’s protein source is 100% by slowing gastric emptying and controlled type 2 diabetes. Diabetes Care. 2009; 32: 1600-1602.
whey protein isolate and can be stimulating insulin response.
Pal S, Ellis, V. The acute effects of four protein meals on insulin, glucose,
incorporated into healthy meals or appetite, and energy intake in lean men. Br J Nutr. 2010; 104: 1241-
used as a snack to help regulate 1248.
blood sugars.
Mortensen LS, Holmer-Jensen J, Hartvigsen ML, Jensen VK, Astrup A, de
Unjury is low in sugar ( ≤ 3 grams Vrese M, Holst JJ, Thomsen C, Hermansen K. Effects of different fractions
per serving) and won’t complicate of whey protein on postprandial lipid and hormone responses in type 2
diabetes. Eur J Clin Nutr. 2012; 66: 799-805.
blood glucose control.
Using Unjury Protein regularly as Whey protein may decrease long- Pal S, Ellis V, Dhaliwal S. Effects of whey protein isolate on body
part of a healthy diet may help term blood insulin levels and improve composition, lipids, insulin, and glucose in overweight and obese
insulin sensitivity. individuals. Br J Nutr. 2010; 104: 716 – 723.
with long-term management of
diabetes.
Unjury Protein helps you feel Whey protein consumption was Anderson GH, Tecimer SN, Shah D, Zafar TA. Protein source, quantity, and
full and satisfied which helps found to have greater subjective time of consumption determine the effect of proteins on short-term food
reports of satiety, delays the return intake in young men. J Nutr. 2004; 134: 3011 – 3015.
“crowd out” sugary, unhealthy
food choices and may lead to of hunger, and can lead to greater
suppression of food intake.
reductions in caloric intake,
which promotes healthy weight
loss and may also lead to
improved diabetes management.
Pregnancy
Advice to Patients Clinical Indications Research
Pregnant women need protein. Consuming adequate protein during Institute of Medicine of the National Archives. Dietary Reference Intake:
pregnancy is critical for positive The Essential Guide to Nutrient Requirements. Washington, D.C.: The
Unjury is a safe and effective way pregnancy outcomes. National Academies Press; 2006.
to get the protein needed for
healthy growth, development, Current RDAs for protein Picciano MF. Pregnancy and lactation: physiological adjustments,
and support of the fetus, and during pregnancy nutritional requirements and the role of dietary supplements. J Nutr.
maintaining the health of 2003; 133: 1997S – 2002S.
important tissues and organs of • First half of pregnancy
the mother, like her heart, blood, = 0.8 g/kg/day
breasts, and uterus. Protein intake
• Second half of pregnancy
may suffer during the first trimester
= 1.1 g/kg/day
due to nausea and related
symptoms. Unjury is an easy
and well-tolerated way to meet
essential protein needs while also
potentially improving nausea.
Protein needs during the second
half of pregnancy are ~25 g/day
higher than that of non-pregnant
adults, based on the current RDAs.
An easy way to get that extra
protein: Unjury mixed with 8 oz of
unsweetened almond milk for a
total of 24 g of protein.
www.unjury.com
For Professional Samples and Wholesale Information, Email: RD@UNJURY.com ©Copyright UNJURY Protein 2015Pregnancy (Continued)
Advice to Patients Clinical Indications Research
Many maternal adaptations Results of a new study suggest that Stephens TV, Payne M, Ball RO, Pencharz PB, Elango R. Protein
involving protein occur early in “dietary protein needs are increased requirements of healthy pregnant women during early and late gestation
compared with non-pregnant adults are higher than current recommendations. J Nutr. 2015; 145: 73 – 78.
pregnancy, followed by a steady
increase in demand as pregnancy from early gestation (~16 weeks) and
onwards.”
progresses.
“The estimated average protein
Unjury can be used as a high- requirements for healthy pregnant
quality protein source early in women during early and late
pregnancy to help meet protein gestation were determined to be
needs while also reducing 1.22 g/kg/day and 1.52 g/kg/day,
morning sickness, and can respectively.”
continue to be used throughout
gestation to promote the health
of mother and baby.
Unjury can help moms of Women carrying twins should Institute of Medicine of the National Archives. Dietary Reference Intake:
multiples meet their high protein increase their protein intake by an The Essential Guide to Nutrient Requirements. Washington, D.C.: The
additional 50 g/day beginning in the National Academies Press; 2006.
needs without adding significant
amounts of sugars/carbohydrates second trimester.
and fat that could contribute to
excessive weight gain.
First-trimester nausea affects 50- Protein-dense meals improve Jednak MA, Shadigian EM, Kim MS, Woods ML, Hooper FG, Owyang
80% of pregnant women,however symptoms of women with first- C, Hasler WL. Protein meals reduce nausea and gastric slow wave
trimester nausea to a significantly dysrhythmic activity in first trimester pregnancy. Am J Physiol. 1999;
the reasons behind its occurrence 277: G855 – G861.
remains poorly understood. It greater degree than carbohydrates,
fats, or noncaloric meals.
is possible that slow gastric wave
dysrhythmias may be the cause.
Protein seems to stabilize these
gastric dysrhythmias and improve
nausea. Unjury provides 21 g
of protein per serving that may
help reduce nausea in pregnancy
while also helping women meet
their elevated protein needs for
fetal development.
Women who have used Unjury
during pregnancy tell us that our
Chicken Soup flavor is particularly
well-tolerated and delicious.
Recommendations to consume
solid carbohydrate meals
(ie crackers) are actually based
largely on anecdotal reports,
not scientific evidence.
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For Professional Samples and Wholesale Information, Email: RD@UNJURY.com ©Copyright UNJURY Protein 2015Lactation
Advice to Patients Clinical Indications Research
The importance of protein doesn’t Current RDAs for protein for Institute of Medicine of the National Archives. Dietary Reference Intake:
end after pregnancy. lactating women: The Essential Guide to Nutrient Requirements. Washington, D.C.: The
National Academies Press; 2006.
Nutritional demands during • 1.3 g/kg/day (~71 g/day)
lactation are considerably greater
than those of pregnancy.
Unjury is a safe way for lactating
mothers to get the protein they
need to support healthy milk
production without excess sugars
or fats that may hinder post-
partum weight loss.
Aging
Advice to Patients Clinical Indications Research
Seniors need more protein. New evidence shows that optimal Bauer J, Biolo G, Cederholm T, Cesari M, Cruz-Jentoft AJ, Morley JE,
protein intake for older adults is Phillips S, Sieber C, Stehle P, Teta D, Visvanathan R, Volpi E, Boirie Y.
higher than the level currently Evidence-based recommendations for optimal dietary protein intake in
Unjury is a safe and easy way for older people: a position paper form the PROT-AGE study group. J Am
older adults to help meet their recommended for adults
Med Dir Assoc. 2013; 14:542-559.
of all ages.
protein needs, especially those
who have difficulties getting their Studies suggest protein needs for Morley JE, Argiles JM, Evans WJ, Bhasin S, Cella D, Deutz NEP, Doehner
protein from food sources due to older adults may range from 1.0 – W, Fearon KCH, Ferrucci L, Hellerstein MK, Kalantar-Zadeh K, Lochs
taste changes, food aversions, and 1.2 g/kg/day and up to 1.5 g/kg/day H, MacDonald N, Mulligan K, Muscaritoli M, Ponikowski P, Posthauer
changes in appetite. for older adults who exercise or are ME, Fanelli FR, Schambelan M, Schols AMWJ, Schuster MW, Anker SD.
regularly active. Nutritional recommendations for the management of sarcopenia. J Am
Unjury is also very low in lactose, Med Dir Assoc. 2010; 11:391-396.
making it extremely well-tolerated Protein needs are also increased
Beasley JM, Shikany JM, Thomson CA. The role of dietary protein intake
in older adults who experience for older adults with chronic or
in the prevention of sarcopenia of aging. Nutr Clin Pract. 2013; 28:
lactose intolerance. acute illnesses, ranging from 684-690.
1.2-1.5 g/kg/day.
Unjury is a high-quality, whey Ingestion of 15 g of whey protein Paddon-Jones D, Sheffield-Moore M, Katsanos CS, Zhang XJ, Wolfe RR.
protein isolate that contains stimulates muscle protein synthesis Differential stimulation of muscle protein synthesis in elderly humans
in elderly, possibly because of its following isocaloric ingestions of amino acids or whey protein. Exp
21 g of protein per serving Gerontol. 2006; 41:215-219.
that is easy for older adults significant leucine content, which
plays an important role in muscle
to incorporate into their diets Beasley JM, Shikany JM, Thomson CA. The role of dietary protein intake
synthesis.
as fortification to low-protein in the prevention of sarcopenia of aging. Nutr Clin Pract. 2013; 28:
684-690.
meals or as snacks between “Consider protein supplementation
meals. in patients with sarcopenia who are Paddon-Jones D, Rasmussen BB. Dietary protein recommendations and
unsuccessful meeting protein needs the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care. 2009; 12:
through diet modification alone and 86-90.
there are no medical
contraindications.”
www.unjury.com
For Professional Samples and Wholesale Information, Email: RD@UNJURY.com ©Copyright UNJURY Protein 2015Stroke
Advice to Patients Clinical Indications Research
Protein may aid recovery after Protein supplementation may Aquilani R, Scocchi M, Iadarola P, Franciscone P, Verri M, Boschi F, Pasini
a stroke. enhance neurological recovery E, Viglio S. Protein supplementation may enhance the spontaneous
in subacute patients with recovery of neurological alterations in patients with ischemic stroke. Clin
Rehabil. 2008; 22: 1042 - 1050.
Brain protein synthesis is ischemic stroke through amino
acid reactivation of brain protein
important for the survival of
synthesis.
neurons, which are the basic
building blocks of the
nervous system.
Unjury Protein can be used to
supplement the diets of post-
stroke patients, can be mixed
successfully with food thickeners
(if necessary), and can be used
along with enteral formulas via
feeding tubes.
Poor nutrition is common Protein and energy supplements Geeganage C, Beavan J, Ellender S, Bath PM. Interventions for dysphagia
among patients after a stroke. may benefit patients with and nutritional support in acute and subacute stroke. Cochran Database
malnutrition following stroke, for Syst Rev. 2012; 10.
Unjury can be used in efforts to
prevent or reverse malnutrition example, reducing pressure sores.
and hopefully reduce nutrition-
related complications.
This study may suggest that Enteral formulas containing whey Eduardo de Aguilar-Nascimento J, Prado Silveira BR, Dock-Nascimento
whey, which is Unjury’s only protein may decrease inflammation DB. Early enteral nutrition with whey protein or casein in elderly
and increase antioxidant defenses patients with acute stroke: a double-blind randomized trial. Nutrition.
protein source, could provide 2011; 27: 440-444.
additional benefits to patients in elderly patients with ischemic
stroke, compared to casein-
after stroke.
containing formula.
More research is likely needed on this Findings suggest that moderate Zhang Z, et al. Quantitative analysis of dietary protein intake and stroke
topic, but is an interesting suggestion dietary protein intake may lower risk. Neurology. 2014.
the risk of stroke.
(some evidence suggestions that
animal protein, with the exception
of red meat was slightly more
effective than vegetable protein,
although there was not enough
data on vegetable consumption to
reach a definitive conclusion)
www.unjury.com
For Professional Samples and Wholesale Information, Email: RD@UNJURY.com ©Copyright UNJURY Protein 2015Cardiovascular Disease
Advice to Patients Clinical Indications Research
Consuming more protein
may be linked to better
cardiovascular health.
Hypertension Reductions in blood pressure and Pal S, Radavelli-Bagatini S. The effects of whey protein on
thus a reduced risk of developing cardiometabolic risk factors.
- It is thought that whey reduces hypertension may be promoted by Obes Rev. 2013; 14: 324 – 343.
blood pressure through consuming whey protein isolate.
lactokinins that inhibit ACE
(angiotensin-converting
enzyme), the enzyme that
controls vasoconstriction.
Lipid Metabolism
- Whey may improve lipid Whey protein seems to improve Pal S, Ellis V, Dhaliwal S. Effects of whey protein isolate on body
composition, lipids, insulin, and glucose in overweight and obese
metabolism by inhibiting lipid profiles of both animals and
individuals. Br J Nutr. 2010; 104: 716 – 723.
cholesterol synthesis in the liver. humans. In a study conducted with
overweight and obese individuals,
- Further studies are needed to supplementation with whey protein
reduced plasma total cholesterol
strengthen these relationships,
and LDL cholesterol after 12
but it appears that incorporating weeks in comparison to a group
Unjury into a healthy diet may supplemented with casein
provide additional health (and a control group).
benefits, such as cardiovascular
improvements.
Critical Care and Enteral Feedings
Advice to Patients Clinical Indications Research
Protein is a top priority in Protein needs can be significantly McClave SA, Martindale RG, Vanek VW, McCarthy M, Roberts P, Taylor
critical care. elevated in the critical care setting. B, Ochoa JB, Napolitano L, Cresci G. Guidelines for the provision and
assessment of nutrition support therapy in the adult critically ill patient:
Society of Critical Care Medicine (SCCM) and American Society for
Protein appears to be the most Protein requirements are typically
Parenteral and Enteral Nutrition (A.S.P.E.N.). J Parenter Enteral Nutr.
important macronutrient for in the range of 1.2-2.0 g/kg of body
2009; 33: 277 – 326.
wound healing, supporting weight per day, and may likely
be even higher in burn or multi-
immune function, and maintaining
trauma patients.
lean body mass in the critical
care setting. Protein should be provided in a
range ≥ 2.0 g/kg ideal body weight
For most critically ill patients, per day for patients with BMIs of
protein requirements are 30-40, and ≥ 2.5 g/kg ideal body
proportionately higher than weight for patients with BMIs >40.
energy requirements.
Unjury Protein is safe to use in
the critical care setting for patients
able to consume an oral diet or for
those receiving enteral nutrition
support to help them meet their
proportionately higher protein
needs for proper nitrogen balance
and recovery.
www.unjury.com
For Professional Samples and Wholesale Information, Email: RD@UNJURY.com ©Copyright UNJURY Protein 2015Critical Care and Enteral Feedings (Continued)
Advice to Patients Clinical Indications Research
Unjury Protein can be used as a Use of additional modular protein McClave SA, Martindale RG, Vanek VW, McCarthy M, Roberts P, Taylor
modular supplement with supplements is a common practice, B, Ochoa JB, Napolitano L, Cresci G. Guidelines for the provision and
as standard enteral formulations assessment of nutrition support therapy in the adult critically ill patient:
enteral feeding regimens. It is Society of Critical Care Medicine (SCCM) and American Society for
easily administered, has a low tend to have a high non-protein
Parenteral and Enteral Nutrition (A.S.P.E.N.). J Parenter Enteral Nutr.
calorie to nitrogen ratios.
rate of tube feeding clogs when 2009; 33: 277 – 326.
administered properly, boosts
protein by 21 g (for only 90- 100
total calories), and has negligible
amounts of lactose for improved
tolerance.
Stir one packet of Unjury into
90ml of tepid/warm tap water
until dissolved. Administer
immediately via syringe through
the feeding tube (not directly
mixed into the feeding bag).
Then flush tube with 30 ml
of water.
Chyle Leaks
Advice to Patients Clinical Indications Research
Fat-free, protein-rich For patients who are well-nourished McCray S, Rees Parrish C. Nutritional management of chyle leaks:
supplements can be a valuable and able to take food by mouth, a an update. Nutritional Issues in Gastroenterology, Series #94. Pract
fat-free oral diet may be an option Gastroenterol. 2001: 12 – 32.
tool in chyle leak management.
for chyle leak management with
the goal of also trying to prevent
Unjury Protein is fat-free and
malnutrition.
provides much needed protein
and calories to prevent
malnutrition.
Unjury can be mixed with a
variety of fat-free liquids including
skim milk, juice, lemonade, and
tea. Chicken Soup and Strawberry
Sorbet, can be successfully mixed
with water.
www.unjury.com
For Professional Samples and Wholesale Information, Email: RD@UNJURY.com ©Copyright UNJURY Protein 2015COPD
Advice to Patients Clinical Indications Research
Many people with COPD fail to Intake of energy and protein below Yazdanpanah L, Shidfar F, Javad Moosavi A, Heidarnazhad H, Haghani H.
meet their protein needs. their demand is common in Energy and protein intake and its relationship with pulmonary function in
patients with COPD. chronic obstructive pulmonary disease (COPD) patients. Acta Med Iran.
2010; 48: 374 – 379.
Malnutrition is common in COPD
The prevalence of malnutrition is
and is associated with increased Akner G, Cederholm T. Treatment of protein-energy malnutrition in
reported to vary between 20% and
disability, diminished respiratory 70% for different patient groups
chronic nonmalignant disorders. Am J Clin Nutr. 2001; 74: 6-4.
and muscle strength and with COPD and appears to be
endurance, alteration in ventilator the highest in combination
capacity, increased susceptibility with emphysema.
to infections and impaired
quality of life.
Unjury can be used by patients
with COPD to supplement meals or
between meals to help meet their
protein and energy demands.
The anti-inflammatory The combination of anti- Sugawara K, Takahashi H, Kashiwagura T, Yamada K, Yanagida S, Homma
properties of whey along with inflammatory nutritional M, Dairiki K, Sasaki H, Kawagoshi A, Satake M, Shioya T. Effect of anti-
supplementation with whey peptide inflammatory supplementation with whey peptide and exercise therapy
its ability to promote muscle in patients with COPD. Respir Med. 2012; 106: 1526 – 1534.
synthesis during exercise/ and low-intensity exercise was
successful in increasing weight and
strength training, may be the
energy intake as well as exercise
reason for the improvements capacity in patients with COPD.
seen in COPD patients.
Unjury’s protein source is
100% high-quality whey
protein isolate.
Cystic Fibrosis
Advice to Patients Clinical Indications Research
Nutritional needs for people Nutritional guidelines for individuals White H, Morton AM, Peckham DG, Conway SP. Dietary intakes in adult
with Cystic Fibrosis are elevated, with CF recommend meeting 200% patients with cystic fibrosis – do they achieve guidelines? J Cyst Fibros.
2004; 3: 1-7.
including protein requirements. of the reference nutrient intake
(RNI) for protein.
Unjury Protein is a concentrated
source of high-quality whey < 40% of adult cystic fibrosis
protein that can be added to patients achieve the recommended
high-calorie, high-fat beverages intake for protein and only 28%
or foods (whole milk, milkshakes, achieve their needs for both energy
etc.) that can help adults with and protein.
cystic fibrosis meet their elevated
energy, protein, and fat needs. The introduction of oral
supplements results in increased
energy and protein intake.
www.unjury.com
For Professional Samples and Wholesale Information, Email: RD@UNJURY.com ©Copyright UNJURY Protein 2015Cystic Fibrosis (Continued)
Advice to Patients Clinical Indications Research
Glutathione is an anti-oxidant Dietary supplementation with a Grey V, Mohammed SR, Smountas AA, Bahlool R, Lands LC. Improved
that functions as a major front- whey-based product can increase glutathione status in young adult patients with cystic fibrosis
glutathione levels in cystic supplemented with whey protein. J Cyst Fibros. 2003; 2: 195 – 198.
line defense against oxidants
in the lungs. Inflammation, fibrosis which may be useful in
counteracting the deleterious
as present in CF, increases the
effects of oxidative stress in the
demand for glutathione and lungs of these patients.
may also be limited if nutritional
status is compromised.
Whey supplements, like Unjury
Protein, are rich in cysteine, an
important precursor of
glutathione.
Malnutrition
Advice to Patients Clinical Indications Research
Inadequate protein intake plays Available data indicates that Akner G, Cederholm T. Treatment of protein-energy malnutrition in
a large role in the development nutritional supplements can chronic nonmalignant disorders. Am J Clin Nutr. 2001; 74: 6-4.
have positive effects when given
of malnutrition. to chronically ill, nonmalignant
patients with Protein-Energy Milne AC, Potter J, Vivanti A, Avenell A. Protein and energy
Unjury can be mixed into a variety Malnutrition or at risk for PEM. supplementation in elderly people at risk for malnutrition. Cochran
of energy-rich foods and beverages Database Syst Rev. 2009; 2.
to help supply patients with the Protein-energy supplementation
protein and energy they need in elderly patients at risk for
for prevention or reversal of malnutrition appears to result in
small, but consistent weight gain,
malnutrition. The versatility and benefit mortality in patients who
great taste of Unjury makes it a are undernourished, and may also
product that yields great patient reduce the risk of complications.
compliance, which leads to
better nutrition results.
Wounds/Decubitus Ulcers/Burns
Advice to Patients Clinical Indications Research
The role protein plays in the Increased protein levels have been Dorner B. Posthauer ME, Thomas D. The role of nutrition in pressure
repair and rebuilding of tissue is associated with improved healing ulcer prevention and treatment: National Pressure Ulcer Advisory Panel
rates. Protein deficits tend to white paper. 2009.
well established.
correlate with higher wound
Arnold M, Barbul A. Nutrition and Wound Healing. Plast Reconstr Surg.
complication rates, increased
Adequate protein intake is crucial 2006; 117: 42S-58S.
incidents of infection, and
for patients with wounds or burns increased wound failure.
as it ensures cell multiplication
and collagen and connective Recommended guidelines for protein
tissue formation. provisions are between 1.25 – 1.5
g/kg body weight/day (Agency for
Unjury can be used as a high Healthcare Research and Quality).
quality protein supplement for Clinical judgement should be used
patients with elevated protein as protein needs may be higher for
requirements to aid wound patients with multiple wounds, exuding
healing. wounds with significant nitrogen losses,
and other comorbidities.
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For Professional Samples and Wholesale Information, Email: RD@UNJURY.com ©Copyright UNJURY Protein 2015Wounds/Decubitus Ulcers/Burns (Continued)
Advice to Patients Clinical Indications Research
Adequate protein intake is “Intact protein, particularly of whey Cresci G. Nutrition Support for the Critically Ill Patient: A Guide to
crucial for patients with wounds source, has been proved superior Practice. Boca Raton, FL: Taylor & Francis Group; 2005.
or burns as it ensures cell to free amino acids in maintaining
body weight and nitrogen Chan MM, Chan GM. Nutritional therapy for burns in children and adults.
multiplication and collagen and J Nutr. 2009; 25: 261 – 269
retention.”
connective tissue formation.
“High-protein regimens in stable
Unjury is a protein-dense, whey burn patients have shown
protein isolate supplement achievement of nitrogen balance,
that can be consumed orally by increased rates of restored body
burn/would patients in addition weight and muscle function, and
better immune function. High
to their diet. Or it can be
protein regimens (>1.5 g/kg/day)
administered via a feeding tube are recommended for burn patients
to increase total protein delivery until significant wound healing is
to meet elevated requirements achieved.”
of these metabolically stressed
patients without significantly “Patients with burn injuries
affecting greater than 25% TBSA
altering the delivery of other
benefit from approximately 23% of
nutrients (≤ 4 grams of CHO and total calories as protein. Given the
0 g fat/serving). hypermetabolic state of the burn
patient, this may translate to
3 to 5 g/kg/d.”
Renal Disease
Advice to Patients Clinical Indications Research
The importance of protein intake The prevalence of malnutrition is Akner G, Cederholm T. Treatment of protein-energy malnutrition in chronic nonmalignant
disorders. Am J Clin Nutr. 2001; 74: 6-4.
in people with renal disease is high and dietary protein intake is
often overlooked. typically low in patients with chronic
National Kidney Foundation Guidelines. Nutrition in Chronic Renal Failure. Am J Kidney Dis.
renal failure. 2000; 35.
Unjury is a high biological value Malnutrition is an indicator of poor
protein (PDCAAs score of 100%) outcomes in renal failure.
that is safe for renal/dialysis 1.2 g of protein/kgBW/day is
patients to use to help meet their recommended for clinically stable
protein needs. hemodialysis patients to maintain
neutral or positive nitrogen balance.
High-protein foods tend to be At least 50% of that protein should
major sources of nutrients that be of high biological value.
renal patients typically need to 1.2-1.3 g of protein/kgBW/day is
avoid (phosphorus, cholesterol, recommended for clinically stable
and fat). Unjury is fat and patients receiving peritoneal
cholesterol-free, contains 80 mg dialysis. At least 50% of that protein
or less of phosphorus per serving, should be of high biological value.
and 150 mg or less of potassium For patients who are unable to meet
per serving. All flavors, except their protein needs, oral diet may be
chicken soup, are also low in fortified with protein supplements.
sodium and contain 90 mg or less Although protein restriction may be
per serving. necessary for some patients with
chronic renal failure not receiving
dialysis, close nutritional monitoring
is advised, as PEM is common in
these patients and often predates
the onset of renal replacement
therapy initiation.
www.unjury.com
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Advice to Patients Clinical Indications Research
Critically ill renal patients may Acutely ill, catabolic patients National Kidney Foundation Guidelines. Nutrition in Chronic Renal
have difficulties meeting their receiving more intensive dialysis Failure. Am J Kidney Dis. 2000; 35.
elevated protein needs via treatments may tolerate and
benefit from protein intakes greater Cresci G. Nutrition Support for the Critically Ill Patient: A Guide to
oral diet or may be unable to Practice. Boca Raton, FL: Taylor & Francis Group; 2005.
than 1.2-1.3 g/kgBW/day.
consume an oral diet at all.
Protein delivery of 1.5-1.8 g/kgBW/
Enteral formula designed for day may be needed to achieve
renal patients typically only nitrogen balance in patients
provide 1.0 to 1.1 g protein/ with acute renal failure receiving
kgBW when delivered at continuous renal replacement
approximately 30kcal/kgBW. therapy. Patients with severe ARF
Adding Unjury to a renal may have significant protein losses
supplement or enteral feeding and require even greater
regimen can boost protein intake protein delivery.
without significantly increasing
sodium, phosphorus, potassium,
carbohydrate, or fat intakes.
Vegetarians
Advice to Patients Clinical Indications Research
Protein quality may be lacking in Protein needs might be higher for Mangels AR, Messina V, Vesanto M. Position of the American Dietetic
the diets of some vegetarians. some vegetarians whose dietary Association and Dietitians of Canada: Vegetarian Diets. J Am Diet Assoc.
protein sources are mainly those 2003; 103: 748 – 765.
Unjury is a complete protein that that are from plant proteins that
are not as easily digested, such as
provides all essential amino acids,
some cereals and legumes.
is especially high is lysine, and is
acceptable for lacto-ovo The essential amino acid, lysine, is
vegetarians. low in many non-animal sources
of protein.
HIV
Advice to Patients Clinical Indications Research
Protein may help people living The protein needs of people American Dietetic Association. HIV/AIDS evidence-based nutrition
infected with HIV are highly practice guideline. Chicago (IL): American Dietetic Association; 2010.
with HIV/AID minimize lean
individualized and can be Various p.
body mass wasting that is often
influenced by the presence of
associated with the disease. Fields-Gardner C, Campa A. Position of the American Dietetic
opportunistic infections and other
Association: Nutrition Intervention and Human Immunodeficiency Virus
disease-related complications. Infection. J Am Diet Assoc. 2010; 110: 1105-1119.
Unjury is a protein-rich
supplement that can be used to High-protein diets do appear to
meet the often elevated protein be beneficial for people living with
and energy needs of patients HIV/AIDS to help preserve lean
with HIV/AIDS. body mass. Protein is also involved
in many of the reactions that are
involved in immunity.
www.unjury.com
For Professional Samples and Wholesale Information, Email: RD@UNJURY.com ©Copyright UNJURY Protein 2015HIV (Continued)
Advice to Patients Clinical Indications Research
Whey supplements, like Unjury Whey protein formulas are an Micke P, Beeh KM, Schlaak JF, Buhl R. Oral supplementation with whey
Protein, are rich in the amino effective and well tolerated way to proteins increases plasma glutathione levels of HIV-infected patients. Eur
increase glutathione levels in HIV- J Clin Invest. 2001; 31: 171-178.
acid cysteine, an important
precursor of glutathione and may infected individuals.
provide additional benefits to
The role glutathione plays in disease
patients infected with HIV. progression is somewhat unclear,
but HIV infection is characterized by
a deficiency in glutathione related
to an enhanced oxidant burden.
Studies looking at glutathione
supplementation are hopeful that
it is a potential target for adjuvant
therapy in HIV patients
PCOS
Advice to Patients Clinical Indications Research
High-protein diets appear to Obesity appears to be associated Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of
benefit women with PCOS in with PCOS, but the exact link polycystic ovary syndrome. Clin Epidemiol. 2013; 6: 1-13.
many ways. remains somewhat unclear.
Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yidiz BO. The
Studies looking at rates of obesity
Many women with PCOS are in women diagnosed with PCOS
prevalence and features of the polycystic ovary syndrome in an
unselected population. J Clin Endocrinol Metab. 2004; 89: 2745 – 2749.
overweight or obese. A weight loss vary, with numbers ranging from
of 5% can help improve insulin around 30% to over 80%. Clark AM, Thornley B, Tomlinson L, Galletley C, Norman J. Weight loss in
resistance, lower levels of male obese infertile women results in improvement in reproductive outcome
hormones, improve menstrual Diet can play an important role in for all forms of fertility treatment. Hum Reprod 1998; 13: 1502-1505
function and reduce cholesterol the management of PCOS. Studies
have shown that diets higher in Lipea GU, Sengupta A, Karsies D. Polycystic Ovary Syndrome (PCOS) and
abnormalities. Weight loss can other androgen excess-related conditions: can changes in dietary intake
protein (40% of total calories) and
also increase fertility. make a difference? Nutr Clin Pract. 2008; 23: 63-71.
lower in carbohydrates tend to
Research shows that women with result in more successful weight
Grassi A. Recognition and treatment approaches for polycystic ovary
PCOS may benefit from a diet low loss and improvements in syndrome. Women’s Health Report. Summer 2008.
in saturated fat, high in fiber and blood glucose.
high in quality protein. Sorenson LB, Soe M, Halkier HH, Stigsby B, and Astrup A. Effects
A weight loss of only 5 percent can of increased dietary protein-to-carbohydrate ratios in women with
A high-protein diet with 40% of improve insulin resistance, leading polycystic ovary syndrome. Am J Clin Nutr. 2012; 95: 39-48.
total calories coming from protein to lower levels of male hormones
would equal 150 g of protein per (and less facial hair), improved
day on a 1500 calorie diet; women menstrual function, and a reduction
who are more active and consume in cholesterol abnormalities.
more energy each day would
require higher amounts of proteins.
Eating frequent meals (every 3-4
hours) and including protein with
each meal and at snacks also helps
to manage blood sugar levels and
prevents hypoglycemia. High-fiber
diets low in saturated fats and
simple sugars are also beneficial.
Including supplements such as
UNJURY, helps meet elevated
protein needs, can aid in weight
loss, maintains blood glucose
control, and keeps dietary
saturated fat and cholesterol low.
www.unjury.com
For Professional Samples and Wholesale Information, Email: RD@UNJURY.com ©Copyright UNJURY Protein 2015Oncology
Advice to Patients Clinical Indications Research
Protein may help people with Malnutrition is highly prevalent Rock CL, Doyle C, Demark-Wahnefried W, Meyerhardt J, Courneya KS,
cancer avoid complications in oncology patients and is Schwartz AL, Bandera EV, Hamilton KK, Grant B, McCullough M, Byers T,
typically associated with a poorer Gansler T. Nutrition and physical activity guidelines for cancer survivors.
associated with malnutrition. CA Cancer J Clin. 2012; 62: 242-274.
prognosis and reduced tolerance to
Unjury Protein can be mixed with treatments. Causes of malnutrition
Mercadante, S. Nutrition in cancer patients.
a variety of high-calorie and low- in cancer include reduced food Support Care Cancer. 1996; 4: 10 – 20.
calorie foods and beverages to intake, nausea/vomiting, anorexia,
supplement the diets of oncology taste changes, early satiety, and Hopkinson J, Okamoto I, Addington-Hall JM. What to eat when off
patients with elevated protein or elevated nutritional requirements. treatment and living with involuntary weight loss and cancer: a
systematic search and narrative review. Support Care Cancer. 2011; 19:
protein and energy requirements. 1-17.
Nutrient-dense diets, including
Unjury is well-tolerated because adequate protein, are
of its high quality and minimal recommended by most experts Bauer J, Capra S, Battistutta D, Davidson W, Ash S. Compliance with
lactose content and can be used for patients at risk for or who have
nutrition prescription improves outcomes in patients with unresectable
pancreatic cancer. Clin Nutr. 2005; 24: 998-1004.
with foods/beverages already developed malnutrition. Adequate
tolerated or acceptable to protein intake is crucial during
the patient. all phases of cancer progression/
treatment.
Protein needs tend to be harder
to meet when overall oral intake Oral supplements are a valuable
is poor. Unjury helps patients tool in increasing protein and
meet their protein goals and meet energy intake in patients who are
energy requirements when added unable to meet their nutritional
to calorically-dense foods and needs via foods alone.
beverages. In a study of untreated pancreatic
cancer patients, those who
Unjury can be added to meals complied with a nutrition
or used between meals as prescription of 1.5 cans/day of a
snacks. Although Unjury Protein liquid oral supplement improved
is satisfying, patients will still be nutrition-related outcomes and
the supplement did not hinder
able to consume a variety of other
spontaneous food intake.
foods and beverages that make up
a well-balanced diet.
Unjury’s Chicken Soup Flavor and
Unflavored also provide a great
savory alternative to patients with
treatment-related aversions to
sweet flavors.
Unjury provides 21 gm of high- Low, recent protein intake (Dysphagia and Difficulties Chewing
Advice to Patients Clinical Indications Research
Adequate protein intake can The risk of being malnourished is Sura L, Madhavan A, Carnaby G, Crary, M. Dysphagia in the elderly:
be especially difficult in the significantly higher in the presence management and nutritional considerations. Clin Interv Aging. 2012; 7:
of dysphagia following stroke, head 287-298.
presence of dysphagia.
and neck cancer, and in aging.
Foley NC, Martin RE, Salter KL, Teasell RW. A review of the relationship
Unjury can be used in thickened between dysphagia and malnutrition following stroke. J Rehabil Med.
liquids of any consistency and 2009; 41: 707-713.
as a modular protein source for
Garcia-Peris, Paron L, Velasco C, de la Cuerda C, Camblor M, Breton I,
enteral feedings to help patients Herencia H, Verdaguer J, Navarro C, Clave P. Long-term prevalence of
with dysphagia meet their protein oropharyngeal dysphagia in head and neck cancer patients: impact on
needs in hopes of avoiding/ quality of life. Clin Nutr. 2007; 26: 710-717.
reversing malnutrition.
Liver Disease
Advice to Patients Clinical Indications Research
Protein-energy malnutrition is Daily protein intake should be Bianchi G, Marzocchi R, Lorusso C, Ridolfi V, Marchesini G. Nutritional
common among patients with at least 1 g/kg (unless severe treatment of chronic liver failure. Hepatology Research. 2008; 38:
hepatic encephalopathy limits S93-S101.
liver disease and can lead to
poorer outcomes and higher intake); 1.2 g/kg/day can be safely
Cresci G. Nutrition Support for the Critically Ill Patient: A Guide to
administered to patients with
morbidity. Practice. Boca Raton, FL: Taylor & Francis Group; 2005.
cirrhosis, even those that exhibit
episodes of encephalopathy, as
Unjury may help patients with even transient protein restriction
liver disease meet their elevated does not appear to benefit these
protein needs. patients.
Unjury is also a good source of Positive nitrogen balance can
all the BCAAs (branched chain promote hepatic regeneration; a
amino acids). minimum protein intake of 1.2 g/
kg/day has been recommended to
maintain this balance in cirrhotic
Our Chocolate Splendor and
patients.
Classic, Vanilla, Strawbery Sorbet,
and Unflavored proteins are all Critically ill patients with major
low in sodium (90 mg or less acute stress, such as those with
per serving). gastrointestinal bleeding or
infection, will have higher protein
needs and may require
1.5 g/kg/day.
Unjury is a whey protein isolate In patients with untreated NASH Chitapanarux T, Tienboon P, Pojchamarnwiputh S, and Leelarungrayub
that can be consumed by patients (Nonalcoholic steatohepatitis), D. Open-labeled pilot study of cysteine-rich whey protein isolate
the degree of hepatic steatosis supplementation for nonalcoholic steatohepatitis patients. J
with NASH for possible treatment Gastroenterol Hepatol. 2009; 24: 1045-1050.
decreased significantly after 12
benefits, assistance in meeting
weeks of whey protein isolate
their elevated protein needs, supplementation.
and may also aid weight loss for
patients who may need it. Modest, but statistically significant,
NASH is now thought to be a weight loss and reduction in BMI
was also seen in this population
common manifestation or even a
receiving 12 weeks of whey protein
predictor of metabolic syndrome, isolate supplementation.
making the additional benefit of
weight loss due to whey protein
isolate use even more important.
www.unjury.com
For Professional Samples and Wholesale Information, Email: RD@UNJURY.com ©Copyright UNJURY Protein 2015Inflammatory Bowel Disease
Advice to Patients Clinical Indications Research
Nutritional intake is frequently IBD is commonly associated with Campos FG, Waitzberg DL, Teixeira MG, Mucerino DR, Habr-Gama A, Kiss
compromised in patients with protein-calorie malnutrition, DR. Inflammatory bowel diseases. Principles of nutritional therapy. Rev
seen in approximately 23% of Hosp Clin. 2002; 57: 187 – 198.
IBD. When oral intake is poor,
protein tends to be the first outpatients and up to 85% of
Lucendo AJ, De Rezende LC. Importance of Nutrition in inflammatory
patients hospitalized for an acute
macronutrient that suffers. bowel disease. World J Gastroenterol. 2009; 15: 2081-2088.
flare. Self-imposed food restriction
and anorexia are the most
Unjury is a safe and well-tolerated common causes of malnutrition
way to improve protein intake for in this population, but increased
those patients with IBD who may bowel movements, malabsorption,
be struggling with meeting their nausea, protein losses from areas
nutritional needs. of inflammation and mucosal
ulceration, and certain drugs can
also impact nutrition status.
Protein needs are typically higher
in IBD patients and are estimated
to be around 1.0-1.5 g/kg body wt/
day for adults and up to 2.0 gm/kg
body wt/day for malnourished or
septic patients.
Eating Disorders
Advice to Patients Clinical Indications Research
Unjury, or any protein, should Adding protein (a liquid, whey Latner JD, Wilson GT. Binge eating and satiety in bulimia nervosa and
not be viewed as a treatment protein supplement) to the diets binge eating disorders: effects of macronutrient intake. Int J Eat Disord.
for eating disorders, as these of women with bulimia and binge 2004; 36: 402-415.
eating disorder reduced food intake
conditions are far more complex
and binge episodes over a two
than simple diet alterations can week time frame.
address. However, this study may
suggest that protein supplements
could be a valuable tool to use
along with conventional treatment
methods to help alter undesirable
behaviors in this population.
More research is needed.
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For Professional Samples and Wholesale Information, Email: RD@UNJURY.com ©Copyright UNJURY Protein 2015Sports Nutrition
Advice to Patients Clinical Indications Research
Athletes and active individuals Scientific evidence supports that Hoffman JR, Falvo MJ. Protein – which is best? J Sports Sci and Med.
benefit from higher protein athletes do benefit from increased 2004; 3: 118-130.
intake. protein intake.
In strength-trained athletes, higher
Athletes of all types benefit from
protein intakes have generally been
higher protein intake than what shown to have positive effects
is recommended for the average on muscle protein synthesis and
person. Higher protein intake size gains. 1.4-1.8 g/kg/day is
improves performance and recommended for strength/power
enhances training efforts. athletes.
Endurance athletes also benefit
from higher protein intakes to
prevent the loss of lean muscle
mass during training.
1.2 – 1.4 g/kg/day is needed
to ensure nitrogen balance in
endurance athletes.
Unjury is a high-quality, whey Whey protein contains a high Hoffman JR, Falvo MJ. Protein – which is best? J Sports Sci and Med.
protein isolate that contains high concentration of branched chain 2004; 3: 118-130.
levels of BCAAs which can amino acids that are important for
help maintain the strength and their role in the maintenance of
tissue and prevention of catabolic
performance gains achieved
actions during exercise.
during exercise/training sessions.
Unjury Protein is convenient and The timing of protein consumption Maughan RJ, Shirreffs SM. Nutrition for sport performance: issues and
easy to use before or after may be more important that opportunities. Proceedings of the Nutrition Society. 2012; 71: 112-119.
exercise. the amount of protein actually
consumed.
Hoffman JR, Falvo MJ. Protein – which is best? J Sports Sci and Med.
Unjury contains 21 g of whey 2004; 3: 118-130.
20 gm of protein consumed just
protein isolate that appears to be before or shortly after training
more effective than other (exercise) may help promote muscle
proteins in promoting muscle remodeling and adaptations; higher
repair and growth. amounts of protein may have
little impact.
Milk protein, especially whey, may
be more effective than some other
proteins in promoting net muscle
protein synthesis after resistance
training.
Whey protein has a greater initial
benefit for protein synthesis related
to its rate of absorption in the body.
Smaller, more frequent ingestion of
whey protein could prove to be of
more value.
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