Bath Salts and Synthetic Marijuana: An Emerging Threat

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Bath Salts and Synthetic Marijuana: An Emerging Threat
Continuing Education
                                                     Course

Bath Salts and
Synthetic Marijuana:
An Emerging Threat
BY Rommie L. Duckworth

                                                           TRAINING THE FIRE SERVICE FOR 135 YEARS

        To earn continuing education credits, you must successfully complete the course examination.
                            The cost for this CE exam is $25.00. For group rates, call (973) 251-5055.
Bath Salts and
            Synthetic Marijuana:
                             An Emerging Threat
                                  Educational Objectives
                                            On completion of this course, students will
 1) Define the term “Designer Drug”.                                    3) Determine what constitutes Bath Salts, and their effects.

 2) Learn how regulation is not inhibiting the production of           4) Determine what constitutes Synthetic Marijuana, and its
     designer drugs.                                                        effects

BY ROMMIE L. DUCKWORTH                                                  emergency responders, and healthcare providers. Designer
                                                                        drugs are chemical compounds that are newly created, modi-
  April 5, 2011. Spanaway, Washington: Medic and Army Ser-              fied, or repurposed to provide abusers with effects similar to
  geant Dave Stewart, high on bath salts bought at a local pipe
  shop, killed himself and his wife during a police pursuit. Their
                                                                        currently illegal recreational drugs. They are often relatively
  five-year-old son was also found dead in the car.                     easy to make and, because of their ever-changing ingredient
                                                                        list, are also extremely difficult to regulate.
  August 21, 2011. Bowling Green, Kentucky: Teenager Ashley                The term “designer drugs” originated in the 1980s, but
  Stillwell became paralyzed while smoking 7H, a form of syn-           the idea of marketing legal chemical combinations related
  thetic marijuana, with her friends. She lay on the floor, helpless,
  as her friends discussed what to do, including how to dispose
                                                                        to regulated or banned drugs dates back to the 1920s. Such
  of her body.                                                          compounds, similar in structure or the effects produced by an-
                                                                        other chemical, are called “analogs.” When morphine, heroin,
  June 5, 2012. Austin, Texas: Eighteen-year-old Giovanni Leask         and other opiates were regulated by the International Opium
  was arrested for attacking and kicking a paramedic in the throat      Convention of 1925, dealers began to sell acetylpropionylmor-
  while he was being treated for injuries resulting from his jump-
  ing off a bridge. Leask was high on bath salts at the time.
                                                                        phine—a similar but as yet unregulated drug.2
                                                                           Most recently, emergency responders are confronting synthet-

A
          round the country and across the news,                        ic marijuana and bath salts across North America and Europe.
          stories like these are playing out with alarming              According to the American Association of Poison Control Cen-
          frequency. Emergency services are confronted by               ters, calls regarding synthetic marijuana almost doubled from
horrific events caused by a surge in the use of new types of            2010 to 2011,3 and calls related to bath salts went up from 304
designer drugs. This article discusses the upsurge in bath salts        in 2010 to more than 6,000 in 2011.4 Not only are these drugs
and synthetic marijuana: what they are, where they have been            cheap and easy to obtain, but many users believe they are legal
coming from, and what form they may take in the future; what            or, at least, that they are unlikely to get arrested for using or
regulators and law enforcement are doing to stop them; and              possessing them.
what field providers can do to manage the fallout from this
new wave of designer drugs.                                             REGULATION
                                                                           In the United States in 1986, the Controlled Substance
Designer Drugs                                                          Analog Enforcement Act was passed to control unregulated
  Although abuse of prescription painkillers like oxycontin             substances that mimic controlled substances. The loophole
remains the largest drug problem in the United States (over-            through which many designer drugs slip is the fact that, un-
doses kill more than 15,000 people per year),1 designer drugs           less specifically banned, chemical substances labeled as “not
present an evolving problem for law enforcement, regulators,            for human consumption” are not considered drugs at all. As a

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emerging threats ●
result, as soon as one “active ingredient” for a designer drug           levels, bath salts can still be purchased through many convenience
is banned, another analog or variant is substituted, continu-            stores, gas stations, head shops, tattoo parlors, and the Internet.
ing the game of catch-up for regulators, law enforcement, and               Routes. Bath salts are typically snorted, but abusers may also
other emergency responders.                                              ingest, inject, or smoke them; insert them rectally directly; or mix
   One explanation for the popularity of these substances is             them with water and use them as eye drops.
the relative difficulty in testing for them in suspected abus-              Mechanism of action. The active ingredients in bath salts
ers; synthetic marijuana is not detectable in standard urine             impact monamine neurotransmitters acting as dopamine-nor-
drug screens. Still, determining what drugs were taken is less           epinephrine reuptake inhibitors (NDRI).8 This, in turn, leads to
important for field providers than managing the signs and                an increase in serotonin and, to a lesser extent, dopamine.9
symptoms resulting from the abuse.                                          Intended effects. The sensations abusers seek may either
   On a federal level on March 1, 2011, a ban on five of the             be those similar to MDMA (Ecstasy) such as increased arousal,
main synthetic cannabinoids (JWH-018, JWH-073, JWH-200,                  sociability, and euphoria or those similar to cocaine and meth-
CP 47,497, and CP 47,497 C8) was enacted, making all of them             amphetamine such as increased mental focus, stimulation, and
Schedule 1 Controlled Substances.5 On September 7, 2011, the             physical energy. Bath salts are often used in combination with
United States Drug Enforcement Agency invoked “emergency                 other recreational substances such as alcohol, marijuana, am-
scheduling” on the three primary active ingredients in bath salts        phetamines, LSD, opiates, benzodiazepines, and other designer
to restrict sales from October 7, 2011, to October 7, 2012.6             drugs for a combination of effects.
   Although federal bans help control large distributors and                Unintended effects. The results can vary widely depending
cross-state trafficking, state and local authorities must also           on product strength, active ingredients and fillers, dosing, route
act to affect individual users and local distributors. As of this        of administration, and individual physiology. Because of this,
writing, most states have banned at least some of the active             bath salts frequently produce undesired cardiac side effects in-
ingredients in these designer drugs, but the degree to which             cluding tachycardia, hypertension, hyperthermia, and peripheral
these drugs are manufactured, distributed, sold, possessed, or           vasoconstriction and neurological side effects including insomnia,
used still varies widely.                                                depression, hallucinations, anxiety, psychosis, paranoia, confu-
                                                                         sion, and excited delirium.10 In addition, bath salts have been
BATH SALTS                                                               reported to produce a high craving for immediate re-dosing,
   What are they? Never intended for use as actual bath salts,           leading to increases in the frequency and intensity of these unde-
these chemicals have virtually nothing in common with the                sired side effects.
Epsom salts you might use to relax in your tub after a long                 Duration. The duration of effects varies greatly in the same way
shift. These recreational drugs are marketed as products “not for        that the effects themselves can. Onset of action (the “come up”
human consumption” to avoid state and federal regulation as              phase) is typically from 30 minutes to two hours, with the “peak”
drugs or food substances. They are instead sold as plant fertil-         at approximately 90 minutes and the “come down” phase some
izers; insect repellants; pond cleaners; vacuum fresheners; and,         time from two to four hours.
of course, most popularly as bath salts, from which the slang for           Why you might see them. Some patients, thinking that
this category of drug is derived.                                        bath salts are legal products, may readily admit to their use
   Where did they come from? Bath salts arrived in the                   and call for assistance if they begin to experience unpleasant
United States around 2008, but both demand and availabil-                side effects. You might also suspect bath salt abuse in patients
ity of the product exploded in 2010. Typically supplied as a             found to be suddenly hyperactive, paranoid, aggressive, “fiend-
white, brown, or gray powder (depending on the manufactur-               ish” (compulsory drug seeking or re-dosing), suicidal, self-mu-
ing method), bath salts are packaged in small foil or plastic            tilating, or in excited delirium without other explanation.
bags. The active ingredients in these formulations are analogs
of cathinone, a derivative of the khat plant used as a stimu-            SYNTHETIC MARIJUANA
lant for hundreds of years throughout the Middle East and                   What is it? In an effort to circumvent regulation, synthetic
Africa.7 Although cathinone itself is a federal Class I Con-             marijuana, like bath salts, is labeled “not for human consump-
trolled Substance (high potential for abuse, no medical uses),           tion.” Most commonly marketed under the names of “Spice”
the cathinone analogs mephedrone (4-MMC), methylone, and                 and “K2” and labeled as incense, synthetic marijuana is typi-
methylenedioxypyrovalerone (MDPV) are the primary active                 cally sold as loose-leaf herbs in small prepackaged bags or
ingredients in most bath salt concoctions and are not yet                prerolled cigarettes.11 Other common names for synthetic
permanently federally controlled. (5) Not only can a variety of          marijuana include “Genie,” “Yucatan Fire,” “Sence,” “Smoke,”
these active ingredients be found in bath salt mixtures sepa-            “Skunk,” and “Zohai.” Like bath salts, new slang terms and
rately or in combinations, but they can also be mixed with a             brand names for synthetic marijuana continue to develop. Also
variety of “filler” components.                                          like bath salts, various forms of synthetic marijuana can be
   Common brand names of bath salts include “Vanilla Sky,” “Cloud        obtained through local shops and the Internet.
Nine,” “Ivory Wave,” “Aura,” “Blizzard,” “Scarface,” and “White Light-      Where did it come from? Trafficking of synthetic canna-
ning.” The speed at which new products can be produced means             binoids was first reported in the United States in December
that this list may be outdated by the time you finish reading this       2008, when a shipment was seized by U.S. Customs in Dayton,
sentence. Despite ongoing regulatory efforts at the state and federal    Ohio.12

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● emerging threats

    These herbal concoctions list ingredients including plants               Little scientific research has been done on the long-term
 thought to produce cannabis-like effects including Scutellaria           effects of these drugs in humans, but it seems that tolerance
 nana, Nelumbo nucifera, Leonotis leonurus, Nymphaea caerulea,            may develop relatively quickly, leading to a great potential
 Canavalia maritima, Pedicularis densiflora, Zornia latifolia, and        for dependence.18 Not only are the active ingredients in these
 Leonurus sibiricus, but it is now understood that the herbal ingre-      products much stronger than most users expect, but it appears
 dients themselves serve primarily as filler. The active ingredients in   that unknown interactions are producing effects that are the
 these products are typically powdered synthetic cannabinoids that        opposite of what users and healthcare providers would expect
 contain no actual marijuana and are simply mixed or sprayed onto         to see with natural marijuana.19
 the herbs.13 Synthetic cannabinoids are a class of man-made sub-            Intended effects. The effects that users typically seek to
 stances that act as cannabinoid receptor agonists. This means that       obtain through synthetic marijuana products are the same as
 they are chemicals that bind with receptors (CB1 in the brain and        those with natural marijuana including euphoria, relaxation,
 CB2 in the spleen), producing a high similar to that of naturally        and sociability.
 occurring cannabinoids (marijuana, THC).14                                  Unintended effects. As with bath salts, the effects of synthetic
    A number of active ingredients have been found in these               marijuana can vary widely depending on product strength, ac-
 mixtures, all variations and derivatives of pharmaceutical               tive ingredients and fillers, dosing, route of administration, and
 research going back 50 years. This research has long been in             individual physiology. Undesired cardiac side effects of synthetic
 an effort to isolate the undesired psychoactive effects of can-          marijuana include tachycardia, hypertension, and chest pain or
 nabinoids from the therapeutically valuable ones, particularly           myocardial infarction. Neurological side effects including paras-
 for the treatment of nausea and loss of appetite from cancer             thesias, anxiety, psychosis, paranoia, confusion, tremors, seizures,
 chemotherapies.15                                                        hallucinations, and excited delirium. As a result of the psycho-
    Cannabinoid agonists fall into four major groups:                     logical effects of synthetic marijuana, some users present with
 • Analogs of THC developed in the 1960s including HU-120                suicidal ideation, self-mutilation, and highly aggressive behavior.
    (HU stands for Hebrew University, where the chemical was              20-23

    synthesized).                                                            Some users report such little effect from “normal” dosing that
 • Nonclassical cannabinoids such as the cyclohexylphenol                they may use larger quantities in subsequent doses, enhanc-
    (CP) series developed by Pfizer in the 1970s.                         ing the undesired effects. Discussion of synthetic marijuana use
 • Aminoalkylindoles or JWH compounds, developed in the                  on Internet discussion forums and comment threads illustrate
    1990s and named after their inventor, J. W. Huffman.                  the variety and unpredictability of the effects of these drugs.
 • Miscellaneous compounds including fatty acid amides such              Comments range from “I tried the ‘legal’ K2 last night and was
    as oleamide.                                                          not impressed” to “I smoke weed and have for many years! My
    These chemicals are all fairly volatile (vaporize readily) and,       heartbeat started to get my attention. It started to beat harder
 therefore, “smokeable,” and examples from all four groups                and faster. I thought I was going to die or at the very least was
 have been reported to be in synthetic marijuana.                         having a heart attack. The pain was really bad, but the fear of
    Although you probably will not know the specific underlying           dying was worse. This is just a warning. I am not trying to scare
 active ingredient affecting your patient, it is important that you       you.” (17)
 recognize that, like bath salts, synthetic marijuana refers to not          Duration. As with bath salts, the duration of the effects of
 one single product but rather to a wide variety of products with         synthetic marijuana can vary greatly. Onset of action (the “come
 varying active ingredients in varying combinations and with              up” phase) is typically from 15 to 30 minutes, with the “peak” at
 different fillers, which may produce drastic and sudden changes          approximately 90 minutes and the “come down” phase extremely
 in patient condition.16                                                  variable, from one to six hours.
    The primary synthetic cannabinoid currently in use is JWH-               Why you might see them. Like users of bath salts, many
 018. (14) Although JWH-018 is currently banned, more than                users of synthetic marijuana believe that they are using legal
 100 other synthetic cannabinoids that may lead to emergency              products, may admit to their use, and call 911 when they or
 services dealing with ever-changing forms of “legal highs”               someone else begins experiencing side effects. You may sus-
 exist.                                                                   pect synthetic marijuana abuse in patients found to be expe-
    Routes. Synthetic marijuana is typically smoked or eaten in           riencing uncontrollable tremors, seizures, difficulty breathing,
 the same manner as natural marijuana.                                    chest pain, or suddenly becoming anxious, paranoid, aggres-
    Mechanism of action. Natural cannabinoids (such as                    sive, suicidal, self-mutilating, or in excited delirium without
 THC) and synthetic cannabinoids (of which more than 100                  other explanation.
 compounds already exist) act by binding to CB1 and CB2
 receptors. These receptors are linked to proteins that regulate          MANAGEMENT OF
 neurotransmitters. Although, as with bath salts, the variety of          EMERGENCIES
 active ingredients, fillers, doses, and dosing methods will im-            Although there is no “antidote” for either bath salt or synthetic
 pact the effect or “high” of synthetic marijuana, synthetic can-         marijuana intoxication, basic life support (BLS) and advanced life
 nabinoids tend to bind better and longer to the CB receptors             support (ALS) emergency responders can apply a number of very
 than natural THC, generally producing stronger effects.17                good general guidelines to manage suspected emergencies.

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PREPARATION                                                                 —Toxins/Trauma (CHI)
   Police, firefighters, emergency medical service (EMS), and in-hos-       —Infection
pital healthcare providers must work in close coordination to pro-          —Psychiatric
vide care for these patients, and this coordination must begin well         —Shock/Stroke/Seizure
before the call to 911. Law enforcement, EMS, and firefighters called   • (ALS) Establish an IV, and protect it from removal. If you
to the scene must all have the same expectations as to what is going       suspect excited delirium, you may consider a fluid bolus and
to happen as well as who will play what roles. Likewise in-hospital        administration of sodium bicarbonate for shock and rhabdo-
and prehospital healthcare providers must have an understanding of         myolysis according to local protocol.
each other’s protocols and capabilities.                                • The patient will often be hyperthermic. This may be because
                                                                           of prior agitation, the protesting of physical restraint, or
MANAGE THE SCENE                                                           metabolic factors related to the drugs. If this is the case,
• As always, first ensure safety for yourself, your fellow pro-           consider external cooling as you would any other hyperther-
   viders, and bystanders. Remember, patients abusing bath salt            mic patient. Keep in mind that hyperthermia is another key
   and synthetic marijuana are particularly prone to sudden                indicator of excited delirium.
   and violent behavioral changes.                                      • (ALS) Closely monitor the patient’s mental state, level of
• The 911 calls for these patients may not include any informa-           sedation, ECG, pulse oximetry, and other vital signs.
   tion about drug use. Clues and cues to bath salt and synthetic       • Continually reassess your patient, as sudden and drastic
   marijuana use include drug paraphernalia or litter on scene,            behavioral and physiological changes are the hallmarks of
   sudden onset tremors, seizures, difficulty breathing, chest pain,       designer drug-related emergencies.
   anxiety, paranoid, and aggressive or suicidal behavior without       PITFALLS AND PRECAUTIONS
   other explanation. Keep in mind that drugs might not be the          • Preparation for these calls begins with responder education
   patient’s only issue.                                                   and collaboration.
• Cofactors to bath salt and synthetic marijuana-related emer-         • Always keep safety in mind, as conditions can change rapidly
   gencies include police use of chemical (pepper spray) or                on these calls.
   electrical (TASER®) restraint prior to your arrival. Additional-     • Coordinate physical restraint, and be prepared for a pro-
   ly, a patient history of mental illness, multiple types of drugs        longed struggle.
   onboard, and patient comorbid factors such as diabetes or            • If at all possible, do not attempt physical restraint without
   history of respiratory or cardiac problems may be obtainable            chemical restraint.
   only through evidence and bystanders on scene.                       • Do not attempt chemical restraint without physical restraint.
                                                                        • Consider bath salts/synthetic marijuana/other designer drugs
MANAGE THE PATIENT                                                         as an underlying cause of sudden patient changes, such as
• Attempt to establish a patient rapport, but always be pre-              those listed above, without other explanation.
   pared for sudden changes in patient behavior.                        • Consider other causes of altered mental status (AEIOU-
• Coordinate with other emergency responders to physically                TIPS).
   restrain the patient. You can use a variety of methods, but
   be sure to control all four extremities as well as the patient’s     THE FUTURE
   head. Do not use chemical pepper spray, and do not place             Bath Salts
   the patient in a prone or hog-tied position. Keep in mind               More recently termed “research chemicals,” designer drugs
   that physical restraint may be particularly difficult in these       continue to be created, modified, marketed, and abused at an
   patients because of increased strength, decreased pain sensi-        alarming rate. Now that the primary active ingredients in bath
   tivity, and loss of rational thought.                                salts, 4-MMC and MDPV, have been regulated, manufacturers
• (ALS) If possible, pharmaceutical restraints should quickly fol-     are substituting analogs including a-PPP, MPPP, MDPPP, and
   low or occur simultaneously with physical restraint. Administer      other chemical cousins that produce similar intoxicating and
   benzodiazepines such as midazolam (Versed®) or lorazepam             toxic effects. And the ingredients aren’t the only thing evolv-
   (Ativan®) per protocol preferably IN or IM.                          ing. In addition to marketing as bath salts, plant fertilizers, and
                                                                        insect repellants, bath salts are most recently being marketed
MANAGE THE CARE                                                         under the description of electronic screen cleaners and jewelry
• As soon as possible, perform a full physical exam, triaging and      cleaners with names like “M-Shine,” “Freebase,” and “Blast.” 24
   treating signs and symptoms. As always, focus on the ABCs.
• Consider other causes of altered mental states including             Synthetic Marijuana
   those listed in the AEIOU tips mnemonic:                               Likewise, synthetic marijuana is being updated and marketed
    —Alcohol                                                            on Web sites claiming, “There is a new generation of K2 products
    —Endocrine/Electrolytes/Encephalopathy                             that are completely legal everywhere” or “Not covered by any
    —Insulin (hypoglycemia)                                             ban, restriction, or regulation!” Despite state and federal bans,
    —Oxygen (hypoxia)                                                   these new concoctions are likely to continue to progress through
    —Uremia                                                             the more than 100 synthetic cannabinoids differentiated only by

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● emerging threats
                                                                                   12. DEA Diversion Control - Controlled Substance Schedules. deadiversion.
 new names like “K2 Sky,” “K2 Solid Sex,” “K2 Orisha,” “K2 Amazo-                  usdoj.gov. Springfield, VA: DEA; http://www.gpo.gov/fdsys/pkg/FR-2012-
 nian Shelter,” and “K2 Thai Dream.” 25                                            03-01/html/2012-4982.htm.
    Despite ongoing efforts to control the distribution and use                    13. emcdda.europa.eu. (n.d.). emcdda.europa.eu, European Monitoring
 of these designer drugs, emergency responders must be pre-                        Centre for Drugs and Drug Addiction. Paper PDF can be accessed at
                                                                                   http://www.emcdda.europa.eu/publications/thematic-papers/spice.
 pared to deal with this problem as it evolves. Bath salts and
 synthetic marijuana aren’t going away any time soon, and the                      14. Huffman, JWJ, Mabon, RR, Wu, MJM, et al. (1999). Current Medicinal
                                                                                   Chemistry. (Atta-ur-Rahman, ed.) Cannabimimetic Indoles, Pyrroles and
 optimal way to prepare yourself is to know and understand                         Indenes (Vol 6, pp705-720). Boca Raton, FL.
 what these substances are, how they work, and how best to
                                                                                   15. Huffman, J. W., Dai, D., Martin, B. R., & Compton, D. R. (1994). Design,
 manage patients who are users:                                                    Synthesis and Pharmacology of Cannabimimetic Indoles. Bioorganic &
    •M  anage the scene.                                                          Medicinal Chemistry L.etters, 4(4), 563–566.
    •M  anage the patient.                                                        16. Auwärter, V., Dresen, S., & Weinmann, W. (2009). “Spice”and other
    •M  anage the care.                                                           herbal blends: harmless incense or cannabinoid designer drugs? … Mass
                                                                                   Spectrometry.
    You may encounter abusers of bath salts or synthetic marijuana
 under a variety of circumstances. You may not know what they                      17. Bergen, K. (2010, February 17). Kansas lab looked at synthetic mari-
                                                                                   juana’s effect on brain - Columbia Missourian. Missourian, Potent Combina-
 took, how much of it they took, or even what was in it. You may                   tions. Retrieved June 14, 2012, from http://www.columbiamissourian.com/
 not know if your call is going to be fatal or just frightful. But you             stories/2010/02/17/legal-substance-mimic-marijuana-has-harmful-effects/.
 can know how to manage the scene, the patient, and the prehospi-                  18. Zimmermann, U. S., Winkelmann, P. R., Pilhatsch, M., Nees, J. A.,
 tal care that you will need to provide for the best possible patient              Spanagel, R., & Schulz, K. (2009). Withdrawal phenomena and dependence
                                                                                   syndrome after the consumption of “spice gold”. Deutsches Ärzteblatt
 outcome. ●                                                                        international, 106(27), 464–467.
                                                                                   19. AAPCC. (2010, March 24). American Association of Poison Control
 References                                                                        Centers Warn About Dangers of Synthetic Marijuana Product. American
                                                                                   Association of Poison Control Centers. ndria, VA. Retrieved June 14, 2012,
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 Drug Use and Health: (No. 11-4658). oas.samhsa.gov, Summary of National           products-89004037.html.
 Findings. Rockville, MD: Substance Abuse and Mental Health Services
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                                                                                   21. DEA DEA Diversion Control - Controlled Substance Schedules, deadi-
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 ters Synthetic Marijuana Data. aapcc.org, Updated May 23, 2012. Retrieved         usdoj.gov/schedules/orangebook/orangebook.pdf.
 June 13, 2012, from http://www.aapcc.org/dnn/Portals/0/Synthetic%20
 Marijuana%20Data%20for%20Website%205.23.2012.pdf.                                 22. Hoyte, C. O., Jacob, J., Monte, A. A., Al-Jumaan, M., Bronstein, A. C., &
                                                                                   Heard, K. J. (2012). A Characterization of Synthetic Cannabinoid Exposures
 4. AAPCC. (2012b, May 23). American Association of Poison Control Cen-            Reported to the National Poison Data System in 2010. Annals of Emergen-
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 2012, from http://www.aapcc.org/dnn/Portals/0/Bath%20Salts%20Data%20
 for%20Website%205.23.2012.pdf.                                                    23. Mir, A., Obafemi, A., & Young, A. (2011). Myocardial Infarction Associ-
                                                                                   ated With Use of the Synthetic Cannabinoid K2. Pediatrics.
 5. DEA. (2011a, April 1). Microgram Bulletin. (D. E. Administration, Ed.)jus-
 tice.gov, REQUEST FOR INFORMATION ON SYNTHETIC CATHINONES.                        24. Allen, R., & Owens, W. (2012, May 31). FDNY Fireguard Update: Bath
 Retrieved June 13, 2012, from http://www.justice.gov/dea/programs/foren-          Salts. FDNY Center for Terrorism and Disaster Preparedness (CTDP), Legal,
 sicsci/microgram/mg2011/mg0411.pdf.                                               Synthetic Amphetamines. New York, NY. Retrieved June 14, 2012, from
                                                                                   http://www.nysvara.org/news/2012/june/120603.pdf.
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 justice.gov. Springfield, VA. Retrieved June 14, 2012, from http://www.           25. Mazzoni, O., Diurno, M. V., di Bosco, A. M., Novellino, E., Grieco, P.,
 justice.gov/dea/pubs/pressrel/pr090711.html.                                      Esposito, G., Bertamino, A., et al. (2009). Synthesis and Pharmacological
                                                                                   Evaluation of Analogs of Indole-Based Cannabimimetic Agents. Chemical
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 to assess the harm of drugs of potential misuse. The Lancet.
 8. Springer, D. D., Fritschi, G. G., & Maurer, H. H. H. (2003). Metabolism
 of the new designer drug alpha-pyrrolidinopropiophenone (PPP) and
 the toxicological detection of PPP and 4’-methyl-alpha-pyrrolidinopropi-
 ophenone (MPPP) studied in rat urine using gas chromatography-mass
 spectrometry. Journal of Chromatography B, 796(2), 253–266. doi:10.1016/j.
 jchromb.2003.07.008.
 9. Karila, L. (2011). GHB and synthetic cathinones: clinical effects and poten-
 tial consequences - Karila - 2010 - Drug Testing and Analysis - Wiley Online
 Library. Drug testing and analysis.                                                ● ROMMIE L. DUCKWORTH is a career fire lieutenant and
                                                                                    EMS coordinator for the Ridgefield (CT) Fire Department.
 10. Wood, D., Davies, S., & Puchnarewicz, M. (2009). 153. Recreational Use
 of 4-Methylmethcathinone (4-MMC) Presenting with Sympathomimetic                   He has more than 20 years of experience working in career
 Toxicity and Confirmed by Toxicological Screening. Clinical Toxicology             and volunteer fire agencies, public and private emergency
 47:7331.                                                                           services, and hospital-based healthcare systems. He is a
 11. Deluca, P., Schifano, F., Davey, Z., Corozza, O., di Furia, L., Farre, M.,     frequent speaker at national conferences and a regular con-
 Flesland, L., et al. (2010). Psychonaut WebMapping Research Group. psy-            tributor to research programs, magazines, textbooks, and
 chonautproject.eu, Spice Report. London, UK: Psychonaut WebMapping                 new media on fire and emergency service topics.
 Research Group.

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Continuing Education
Bath Salts and Synthetic Marijuana: An Emerging Threat
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COURSE EXAMINATION
1) Which prescription painkiller remains the largest cause of            8) What act was passed in 1986 to control unregulated substances
   overdose deaths in the United States?                                    that mimic controlled substances?
  a. Vicodin                                                               a.	Controlled Substance Enforcement Act
  b.	Oxycontin                                                             b.	Designer Drug Analog Enforcement Act
  c. Tylenol                                                               c. Synthetic Drug and Substance Control Act
  d. Morphine                                                              d.	Controlled Substance Analog Enforcement Act

2)	Designer Drugs are _____________ that are newly created,              9) The loophole through which many Designer Drugs slip is the fact
  modified, or repurposed to provide abusers with effects similar to        that, unless specifically banned, chemical substances labeled as
  currently illegal recreational drugs.                                     “not for human consumption” are not considered drugs at all.
  a.	Chemical Compounds                                                    a. True
  b. Store-bought drugs                                                    b. False
  c.	Combined drugs
  d. Single chemical drugs                                               10) Which drug is usually sold as plant fertilizers, insect repellents,
                                                                              pond cleaners, vacuum fresheners?
3)	Designer Drugs are harder to make than their real counterparts.         a. Bath Salts
  a. True                                                                  b.	Designer Oxycontin
  b. False                                                                 c. Synthetic Marijuana
                                                                           d.	None of the above
4) When did Designer Drugs make an appearance in the United
   States?                                                               11) How are Bath Salts packaged?
  a.   1960s                                                               a.   In   large bricks
  b.   1970s                                                               b.   In   large pails for wholesale
  c.   1980s                                                               c.   In   small foil or plastic bags
  d.   1990s                                                               d.   In   small landscape bags for long-term storage

5)	Chemical compounds used in Designer Drugs are similar in              12) Bath Salts are typically ___________ when used as Designer Drugs.
   structure, or their effects produced by another chemical are
                                                                           a.   Snorted
   called, “analogs”.
                                                                           b.   Smoked
  a. True                                                                  c.   Injected
  b. False                                                                 d.   Eaten

6) According to the American Association of Poison Control Centers,      13) The mechanism of action for Bath Salts is ____________ .
  Calls regarding synthetic marijuana almost _______________ from
  2010 to 2011.                                                            a.	Decrease in Norepinephrine
                                                                           b. Increase in Serotonin
  a.	Doubled
                                                                           c.	Decrease in Serotonin
  b. Tripled
                                                                           d. Increase in Adrenaline
  c. Quadrupled
  d. Quintupled
                                                                         14) What Designer Drug is commonly marketed under such names
                                                                              as “Spice” and “K2?”
7) Many users of Designer Drugs believe they are legal, and that
   they are unlikely to get arrested for using or possessing them.         a. Bath Salts
                                                                           b.	Oxycontin derivatives
  a. True
                                                                           c. Synthetic Marijuana
  b. False
                                                                           d. Synthetic Oxycontin

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Continuing Education
Bath Salts and Synthetic Marijuana: An Emerging Threat
15) How is Synthetic Marijuana used as a Designer Drug?               18) Due to the state of euphoria that most Designer Drug users
                                                                          seek, they are less prone to be sudden and violent behavioral
  a. Smoked or injected
                                                                          changes.
  b. Smoked or eaten
  c. Eaten or ingested                                                  a. True
  d.	Only Smoked                                                        b. False

16) S
     ynthetic Marijuana can produce a stronger “high” than natural   19) Also termed “research chemicals,” Designer Drugs are continuing
    marijuana.                                                             to be created, modified, marketed and abused at an alarming
                                                                           rate.
  a. True
  b. False                                                              a. True
                                                                        b. False
17) What are some signs and symptoms of Synthetic Marijuana use?
                                                                      20) The optimal way to prepare yourself against abusers of Designer
  a.   Tremors                                                             Drugs is to:
  b.   Seizures
                                                                        a.   Manage the scene
  c.   Paranoia
                                                                        b.   Manage the patient
  d.   All of the above
                                                                        c.   Manage the care
                                                                        d.   All of the above

                                                              Notes

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Continuing Education
Bath Salts and Synthetic Marijuana: An Emerging Threat
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