Activities report 2019 - Vall d'Hebron Institute of Oncology
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Activities report 2019
1. Activities in the institutional, organisational and management
areas
The professional team at VHIO and its evolution
VHIO upholds its commitment to safeguard its management structure and to support research, with the
aim of not expanding those areas more than it is necessary. However, VHIO's exponential increase in
projects has translated into the need to marginally increase the number of professionals in both areas to
meet the organisation's challenges and its growth, although - as can be seen in the figure - many of those
additions are funded by projects.
The evolution of the last three closes according to data presented to VHIO's governing bodies can be noted
from the table below (information from 31/12/2019)
2
The following figure sums up the results taking only the year's yearly average staff as a reference.
Male Female Total
Management and support to research 12,35 48,93 61,28
Research 76,03 231,3 307,33
Interns 2,07 2,62 4,69
Total 90,45 282,85 373,30
And the gender distribution is as follows:
3
%
Female 75,77
Male 24,23
Overall total 100
Furthermore, AQuAS submitted gender-disaggregated data appertaining to research staff making up the 19
research centers and institutes, in the form of what's called a "gender scissors diagram". According to data
included in the report, VHIO excels in its position in this matter and reaffirms its commitment to continue
working in the promotion of gender equality.
4
5
We must also stress that we held union elections last December 9 to renew the members of the works
council. The turnout was 64,12%
Additionally, following suggestions from Institució CERCA - the VHIO's patronage - decided to implement
HRS4R.
6
As an initial effort, we conducted the HRS4R survey in 2017, encouraging the involvement of all VHIO
researchers, regardless of their position or seniority, to carry out internal analyses and, in doing so, identify
areas of improvement according to principles outlined in the European Charter for Researchers.
The survey consisted of 40 questions about the 50 principles of the European Charter for Researchers and
the Code of Conduct for the Recruitment of Researchers. VHIO's research staff were requested to rate each
question from 1 to 5 according to their agreement levels. The survey was approved and launched on April
10 2017. The results were analysed in detail and submitted to VHIO's ad-hoc HRS4R committee,
established on July 13, 2017 as the body responsible for the design and monitoring of the implementation
process of HRS4R.
The survey results were used as the basis to prepare the gap analysis, and those were analysed according
to 7 separate categories (gender, nationality, research programme, seniority, employee category and
international exposure) to set up a more personalised and, therefore, more effective action plan. VHIO's
HRS4R committee met again in July 2017 to approve the analysis document and action plan and to be on
time to present it on July 31 2017. As a result of this engagement, we were notified on February 28, 2018, of
our accreditation by the European Commission HR Excellence.
Since then and in the course of 2019 we have been implementing the different actions set out in the action
plan and keeping track through progress indicators to be able to report within the timeline to the European
Commission.
New VHIO premises
During 2019 an agreement was reached with the leadership of Hospital Universitario Vall d'Hebron for the
concession to VHIO of areas close to the current UITM-la Caixa (ground floor of the General Hospital) to
enlarge this unit's facilities, with purpose of:
unifying both pharmacy areas of oncohaematology clinical trials:
o drug management
o preparation of cytostatics
creating a clinical trial oral medication dispensing area
building spaces for an eventual enlargement of the day hospital's capacity
Sponsorship has been provided by Fundación La Caixa, as part of its international programme of support
to research in oncology.
7
8
Negotiation and signature of the first VHIO collective agreement.
A negotiation table for the VHIO collective agreement was settled on March 1 2019. Finally, after collective
bargaining, it was signed with a temporal scope and validity from July 1, 2019 until December 21, 2021.
A commitment by VHIO to the Institució CERCA's Ethical Code and settlement of the code of good
practice in research according to new requirements set out in the ethical code.
VHIO governing bodies committed to apply Institució CERCA's ethical code and the adoption of the good
practice code in research in incoming requirements set out in that ethical code
9
Reaccreditation of the HUVH Healthcare Research Institute after integrating VHIO into the Healthcare
Research Institute
Reaccreditation of the Instituto de Investigación Universitaria (IIS) Vall
d'Hebron by ISCIII took place in the final week of April. That was the first
time it takes place since VHIO became a part, and the second time since
2009 when VHIR was initially accredited. The accreditation plan has
been prepared jointly throughout the past few months, and it is based
on four pillars: the IIS integration plan, the IIS strategic plan, the
stewardship plan for emerging groups, and the IIS training plan.
10Incorporation into VHIO of the oncology clinical trial pharmacy
During the year 2019 the integration of the team and its oncology clinical trial pharmacy into VHIO has
been completed.
This transfer entails the following for VHIO:
• Transferring 10 pharmacy graduates from VHIR
• Transferring 13 senior pharmacy technicians from VHIR
• Transferring an administrative assistant
As a consequence, this costs VHIO 900,000 euros annually, which will be financed with the canon charged
to sponsors (7,5% of the revenue from clinical trials)
Quality, certifications and recognitions area
Following with the strategy and primary goal of cementing the competitive advantages of VHIO in the field of
translational research and clinical trials in the realm of oncology, it is necessary to add as a reminder that in
late 2011 a process of gaining the ISO accreditation was launched for the Genomics and Molecular Oncology
units. The aim of this accreditation process was obtaining formal and
external recognition of processing quality, looking ahead to being able
to formalise agreements with the pharmaceutical industry with some
continuity in the medium to long run.
As a result of this strategy, the ISO90001 accreditation was obtained in 2013 for the activities of
Management of Biomedical Research Projects in Oncology, and ISO 15189 for different analyses carried
out by the Genomics and Molecular Oncology laboratories.
11During this year, different specific audits have
been carried out, commissioned by
pharmaceutical laboratories with signed
agreements for the prospective development
of phase I clinical trials in Oncology, as well as
to assess that VHIO can act as the central
laboratory for research projects and / or
clinical trials.
Also, 16 audits and an inspection by the
regulatory entity have been passed in
oncological research during this year. The evolution is shown in the figure below.
As well as the oncological clinic research audits, three have also been carried out during 2019 for clinical
research in oncohaematology.
Another strategic target in the quality area attained in 2016 and renewed according to a follow-up audit in
2017, and maintaining that target in 2018 and 2019, has been that ENAC (Entidad Nacional de Acreditación)
12has kept the flexible reach for the several analyses carried out in the Molecular Oncology and Cancer
Genomics laboratories. Keeping that flexible accreditation enables us to continue using the accreditation
scope to new analyses without prior request, which will be evaluated in the annual audits.
Concerning the ISO 9001 certification, VHIO has passed the reaccreditation audit, meeting thus the requisites
included in it and renewing the certificate received in 2013.
Also, within this section, it is necessary to emphasize the recognitions as institutional as in the personal field
to professionals of VHIO that have been awarded to us this year 2019.
A. Institutional recognition
The Medical Oncology Department of University Hospital Vall d'Hebron (HUVH), recognised for a sixth
consecutive time in the annual independent evaluation of the Spanish healthcare sector, Monitor de
13Reputación Sanitaria (MRS). It ranks first among clinical services in medical oncology with the best
nationwide reputation for its fourth consecutive year.
B- Personal recognition
Web of Science Group (WoS) has published the list of most-quoted scientists in the world
during 2019 and, once again, Josep Tabernero (for a fourth consecutive year) and Enriqueta
Felip (for a second consecutive year) appear in it. Doctor Tabernero and Doctor Felip are
have been recognised in the clinical medicine section, which this year amounts to a sum of
436 researchers.
Moreover, doctor Tabernero will act as a representative for VHIO at the
Cancer Mission of Horizon Europe, the European Commission's new
funding framework programme, endowed with 100 million euro. Josep
Tabernero has been appointed member of the Assembly which counsels
the board of the Cancer Mission, a team of 26 experts in cancer who will
contribute with their ideas and expertise to assist in the mission’s
success.
14Elena Elez, a medical oncologist of Hospital Universitari Vall d’Hebron and researcher in the
Gastrointestinal and Endocrine Tumour Team at the Vall d’Hebron Institut d’Oncologia (VHIO), was
awarded in March as the best young researcher of ICS at the 10th research conference.
Economic area
In the previous results by the “results central” submitted by AQuAS, VHIO stands out among the research
system centres in its ability to boost by 28 the funding provided by the Catalan government.
Information systems area
During 2019, VHIO has kept steadily upgrading of the information system, especially to be able to provide
the research systems with tools that facilitate their work and activities and to attain a positive impact on
research.
Following that target, during this year we have finished configuring and implementing NorayBanks. This is a
web application specifically designed for the management of biological sample collections and specially
designed for biobanks and biorepositories.
15NorayBanks facilitates the running of internal activities (specimens/donors and sample management,
labelling, processing, storage…) to different research teams.
This system has been used in different collectives already, such as Seroteca and Molecular Oncology, the
departments working with more samples at VHIO.
Likewise, and in connection with clinical research activity, VHIO, along with Hospital Universitario Vall
d’Hebron, developed a software which allows clinical trial monitors to act directly from clinical stations.
This system allows the clinical trial monitor to access the patient's clinical histories via a username and
password and check the source of the information directly. That entails a big improvement in efficiency, as
it renders unnecessary to print all documents to monitor them. During 2019 all promoters and CROs are
already monitoring using this system.
16Knowledge dissemination area
VHIO, most notably in 2019, has promoted and bolstered activities which are open to society to encourage
and increase social interest in cancer research and the important progress made by our scientists and
clinical researchers. These efforts have the aim to enhance the public’s scientific culture as well as
promoting science as an exciting career path among young people: the future of our research.
Dissemination activities and programmes run by VHIO are aimed at patients, young people and non-
specialist adult audiences.
As part of the “School and Science” programme created by VHIO in 2017, 15 educational establishments
and a total of 1200 students have joined in.
17Also during 2019 VHIO has partaken in other dissemination activities such as “Al cáncer donem-li
recerca” at The Youth Mobile Festival: YoMo, at the Science Festival in the 2019 Heltio event, at
BCNspiracy and 48H Open House BCN.
Moreover, we have kept organising workshops for patients, for instance, the sixth edition of the
workshop for breast cancer patients.
18Vall d’Hebron Institut d’Oncologia (VHIO), in collaboration with the association Dones en Actiu, has
launched a new series of talks of informative nature. Using the name of Patients’ School, last Wednesday of
each month a speech will be offered at the conference hall of Hospital Vall d’Hebron, in which it will be
sought to provide useful information for a better understanding of cancer. Dr Jorge Fernando, a researcher
in the Team of Gastrointestinal and Endocrine Tumours at VHIO, directed by Dr Josep Tabernero, will be the
coordinator of this series, which was launched last Wednesday, January 30.
19Furthermore, VHIO keeps being highly involved in solidarity actions promoted by third parties, which
have a great social impact. An example of that is the growth in the number of donations during the past
years in solidarity projects, such as the “Paseíco de la mama”, Fundació ESADE”, “Pink Run Mir” and
“Masterclass de zumba” projects which have brought together many people year after year to those
activities.
In this same section, but using a different approach based on the current lines
and fields of research which keep positioning VHIO as a leading international
reference, we also share our experience, learn from distinguished guest
speakers, discuss and debate our last findings organising ad hoc courses and
workshops at VHIO.
Our researchers also speak at international conferences of excellence. Intending to
exchange current findings in science and cancer medicine, VHIO has organised
the following number of courses, workshops and other educational activities: 21 in 2015, 29 in 2016, 31 in
2017, 50 in 2018 and also 50 in 2019.
Many activities mentioned above, along with the progress made by our researchers, have been noticed by
media with completely different audiences. Our communications have the main aim to reach the
international scientific community and other key audiences, such as potential partners, funders or
specialised media. An indicator of the impact of these reports about us and
20our research, its breakthroughs and importance, is the big impression on the written press, audiovisual and
social media, as the images of media and the progression figure below shows..
21Technology transfer scope
During 2019, VHIO has continued consolidating the technology transfer programme. VHIO, from its creation
until December 31, 2019, has achieved the following milestones:
22 VHIO researchers have taken part in 23 patent families:
13 families of patents are exploited via VHIO spinoffs (9 Mosaic Biomedicals and 4 Peptomyc)
3 patents have been licensed to leading companies in the pharmaceutical and diagnosis
fields (2 Doctor Arribas, 1 Doctor Prat)
4 patents are exploited directly by companies of international renown (1 doctor Arribas, 1
Doctor Serra, 1 Doctor Palmer, 1 Doctor Soucek)
2 patents are currently in the negotiation stage (Doctor Abad and Doctor Serra)
Abandoned patents (1 Doctor Villanueva)
Creation of 2 spin-offs that will develop new treatments against cancer:
MOSAIC Biomedicals. Several >50M funding rounds have been completed, and it merged
with Northern Biologics for the development of a new therapeutic antibodies portfolio. The
company completed its first Phase-I trial successfully.
PEPTOMYC. It has obtained funding from the international reference venture capital
AltaLife Sciences, and in 2019 it gained an SME Instrument Phase-II fund from the
European Commission to start clinical trials of a new MYC-inhibitory peptide.
The VHIO strategy in this matter has secured its acknowledgement by the community and the media.
232. Scientific activity for 2019 publications
Publications
24During 2019 researchers attached to VHIO have participated in 333 papers, with a cumulative impact
factor of 3806. We must highlight that the number of publications has considerably increased, and the
average impact factor has kept above 11,43.
On another note, an analysis of the quality of the scientific journals in which papers by VHIO researchers
have published shows that a 76% of the publications (see the following figure) were in scientific journals in
the first quartile, and 68% in the first or second decile, cementing the VHIO emphasis on the quality of
publications despite the increased number.
25Main publications (impact factor over 15)
26Research projects
We submitted 207 research projects in 2019, to a 28% success ratio and 20 pending grants. We
presented some projects within the Instituto de Investigación Sanitaria framework, to a 63%
success rate.
Publication Impact Factor
date Title Scope Authors Journal JCR
Hilf, Norbert; Kuttruff-Coqui,
Sabrina; Frenzel, Katrin; Bukur,
Valesca; Stevanovic, Stefan;
Gouttefangeas, Cécile; Platten,
Michael; Tabatabai, Ghazaleh;
Dutoit, Valerie; van der Burg,
Sjoerd H; Thor Straten, Per;
Martínez-Ricarte, Francisco;
Ponsati, Berta; Okada, Hideho;
Lassen, Ulrik; Admon, Arie;
Ottensmeier, Christian H; Ulges,
Alexander; Kreiter, Sebastian; von
Deimling, Andreas; Skardelly,
Marco; Migliorini, Denis; Kroep,
Judith R; Idorn, Manja; RODON
AHNERT, JORDI; Piró, Jordi;
Poulsen, Hans S; Shraibman,
Bracha; McCann, Katy; Mendrzyk,
Regina; Löwer, Martin; Stieglbauer,
Monika; Britten, Cedrik M; Capper,
David; Welters, Marij J P;
Sahuquillo, Juan; Kiesel, Katharina;
Derhovanessian, Evelyna; Rusch,
Elisa; Bunse, Lukas; Song, Colette;
Heesch, Sandra; Wagner, Claudia;
Kemmer-Brück, Alexandra; Ludwig,
Jörg; Castle, John C; Schoor,
Actively Oliver; Tadmor, Arbel D; Green,
personalized Edward; Fritsche, Jens; Meyer,
vaccination trial for Miriam; Pawlowski, Nina; Dorner,
newly diagnosed Sonja; Hoffgaard, Franziska;
01/01/2019 glioblastoma. Article Rössler, Bernhard; Maurer, NATURE 43,070
27Dominik; Weinschenk, Toni;
Reinhardt, Carsten; Huber,
Christoph; Rammensee, Hans-
Georg; Singh-Jasuja, Harpreet;
Sahin, Ugur; Dietrich, Pierre-Yves;
Wick, Wolfgang
Acute liver failure
due to immune-
mediated hepatitis
successfully
managed with
plasma exchange: Riveiro-Barciela, Mar; MUÑOZ
New settings call COUSELO, EVA; Fernandez-Sojo,
for new treatment Jesús; Diaz-Mejia, Nely; Parra- JOURNAL OF
01/03/2019 strategies? Letter López, Rafael; Buti, María HEPATOLOGY 18,946
Shaw, Alice T; Solomon, Benjamin
ALK Resistance J; Besse, Benjamin; Bauer, Todd M;
Mutations and Lin, Chia-Chi; Soo, Ross A; Riely,
Efficacy of Gregory J; Ou, Sai-Hong Ignatius;
Lorlatinib in Clancy, Jill S; Li, Sherry; Abbattista,
Advanced Antonello; Thurm, Holger; Satouchi,
Anaplastic Miyako; Camidge, D Ross; Kao,
Lymphoma Steven; Chiari, Rita; Gadgeel,
Kinase-Positive Shirish M; FELIP FONT,
Non-Small-Cell ENRIQUETA; Martini, Jean- JOURNAL OF CLINICAL
01/06/2019 Lung Cancer Article François ONCOLOGY 28,245
Juric, Dejan; Janku, Filip; RODON
Alpelisib Plus AHNERT, JORDI; Burris, Howard A;
Fulvestrant in Mayer, Ingrid A; Schuler, Martin;
PIK3CA-Altered Seggewiss-Bernhardt, Ruth; Gil-
and PIK3CA-Wild- Martin, Marta; Middleton, Mark R;
Type Estrogen Baselga, Josep; Bootle, Douglas;
Receptor-Positive Demanse, David; Blumenstein,
Advanced Breast Lars; Schumacher, Karl; Huang,
Cancer A Phase Alan; Quadt, Cornelia; Rugo, Hope
01/02/2019 1b Clinical Trial Article S JAMA oncology 22,416
Atezolizumab Rini, Brian I; Powles,
plus Thomas; Atkins, Michael B;
bevacizumab Escudier, Bernard;
15/06/201 versus McDermott, David F;
9 sunitinib in Article SUAREZ RODRIGUEZ, LANCET 59,102
28patients with CRISTINA; Bracarda,
previously Sergio; Stadler, Walter M;
untreated Donskov, Frede; Lee, Jae
metastatic Lyun; Hawkins, Robert;
renal cell Ravaud, Alain; Alekseev,
carcinoma Boris; Staehler, Michael;
(IMmotion151): Uemura, Motohide; De
a multicentre, Giorgi, Ugo; Mellado,
open-label, Begoña; Porta, Camillo;
phase 3, Melichar, Bohuslav; Gurney,
randomised Howard; Bedke, Jens;
controlled trial Choueiri, Toni K; Parnis,
Francis; Khaznadar, Tarik;
Thobhani, Alpa; Li, Shi;
Piault-Louis, Elisabeth;
Frantz, Gretchen; Huseni,
Mahrukh; Schiff, Christina;
Green, Marjorie C; Motzer,
Robert J; IMmotion151
Study Group
Atezolizumab Eng, Cathy; Kim, Tae Won;
with or without Bendell, Johanna; ARGILES
cobimetinib MARTINEZ, GUILLERMO;
versus Tebbutt, Niall C; Di
regorafenib in Bartolomeo, Maria; Falcone,
previously Alfredo; Fakih, Marwan;
treated Kozloff, Mark; Segal, Neil H;
metastatic Sobrero, Alberto; Yan,
colorectal Yibing; Chang, Ilsung; Uyei,
cancer Anne; Roberts, Louise;
(IMblaze370): Ciardiello, Fortunato;
a multicentre, IMblaze370 Investigators;
01/06/201 open-label, Ahn, J B; Asselah, J; LANCET
9 phase 3, Article Badarinath, S; Baijal, S; ONCOLOGY 35,386
29randomised, Begbie, S; Berry, S; Canon,
controlled trial. J L; Carbone, R G;
Cervantes, A; Cha, Y J;
Chang, K; Chaudhry, A;
Chmielowska, E; Cho, S H;
Chu, D; Couture, F;
Cultrera, J; Cunningham, D;
Van Cutsem, E; Cuyle, P J;
Davies, J; Dowden, S;
Dvorkin, M; Ganju, V;
Garcia, R V; Kerr, R; Kim, T
Y; King, K; Kortmansky, J;
Kozloff, M; Lam, K O; Lee,
J; Lee, A S; Lesperance, B;
Luppi, G; Ma, B; Maiello, E;
Mandanas, R; Marshall, J;
Marx, G; Mullamitha, S;
Nechaeva, M; Park, J O;
Pavlakis, N; Ponce, C G;
Potemski, P; Raouf, S;
Reeves, J; Segal, N; Siena,
S; Smolin, A; Streb, J O;
Strickland, A; Szutowicz-
Zielinska, E; TABERNERO
CATURLA, JOSEP; Tan, B;
Valera, J S; Van den Eynde,
M; Vergauwe, P; Vickers, M;
Womack, M; Wroblewska,
M; Young, R
Binimetinib, Van Cutsem, Eric; Huijberts,
Encorafenib, Sanne; Grothey, Axel;
and Cetuximab Yaeger, Rona; Cuyle, Pieter- JOURNAL OF
10/06/201 Triplet Therapy Jan; ELEZ FERNANDEZ, CLINICAL
9 for Patients Article MARIA ELENA; Fakih, ONCOLOGY 28,245
30With BRAF Marwan; Montagut, Clara;
V600E-Mutant Peeters, Marc; Yoshino,
Metastatic Takayuki; Wasan, Harpreet;
Colorectal Desai, Jayesh; Ciardiello,
Cancer: Safety Fortunato; Gollerkeri,
Lead-In Ashwin; Christy-Bittel,
Results From Janna; Maharry, Kati;
the Phase III Sandor, Victor; Schellens,
BEACON Jan H M; Kopetz, Scott;
Colorectal TABERNERO CATURLA,
Cancer Study JOSEP
Rosiñol, Laura; Oriol, Albert;
Rios, Rafael; Sureda, Anna;
Blanchard, María Jesús;
Hernández, Miguel Teodoro;
Martínez-Martínez, Rafael;
Moraleda, Jose M; Jarque,
Isidro; Bargay, Juan;
GIRONELLA MESA,
MERCEDES; de Arriba,
Felipe; Palomera, Luis;
González-Montes, Yolanda;
Bortezomib, Martí, Josep M; Krsnik,
lenalidomide, Isabel; Arguiñano, Jose M;
and González, Maria Esther;
dexamethason González, Ana Pilar;
e as induction Casado, Luis Felipe; López-
therapy prior to Anglada, Lucia; Paiva,
autologous Bruno; Mateos, Maria-
transplant in Victoria; San Miguel, Jesus
17/10/201 multiple F; Lahuerta, Juan-José;
9 myeloma. Article Bladé, Joan BLOOD 16,562
01/02/201 BRCA Lin, Kevin K; Harrell, Maria I; CANCER
9 Reversion Article Oza, Amit M; OAKNIN DISCOVERY 26,370
31Mutations in BENZAQUEN, ANA
Circulating MAZALTOB; Ray-Coquard,
Tumor DNA Isabelle; Tinker, Anna V;
Predict Helman, Elena; Radke,
Primary and Marc R; Say, Carmen; Vo,
Acquired Lan-Thanh; Mann, Elaina;
Resistance to Isaacson, Jeffrey D;
the PARP Maloney, Lara; O'Malley,
Inhibitor David M; Chambers,
Rucaparib in Setsuko K; Kaufmann, Scott
High-Grade H; Scott, Clare L; Konecny,
Ovarian Gottfried E; Coleman,
Carcinoma Robert L; Sun, James X;
Giordano, Heidi; Brenton,
James D; Harding, Thomas
C; McNeish, Iain A; Swisher,
Elizabeth M
Harbeck, Nadia; Penault-
Llorca, Frederique;
CORTES CASTAN, JAVIER;
Gnant, Michael; Houssami,
Nehmat; Poortmans, Philip;
23/09/201 Ruddy, Kathryn; Tsang, Nature Reviews
9 Breast cancer Article Janice; Cardoso, Fatima Disease Primers 32,274
de Wit, Ronald; de Bono,
Johann; Sternberg, Cora N;
Fizazi, Karim; Tombal,
Cabazitaxel Bertrand; Wülfing, Christian;
versus Kramer, Gero; Eymard,
Abiraterone or Jean-Christophe; Bamias,
Enzalutamide Aristotelis; CARLES
in Metastatic GALCERAN, JOAN; NEW ENGLAND
26/12/201 Prostate Iacovelli, Roberto; Melichar, JOURNAL OF
9 Cancer. Article Bohuslav; Sverrisdóttir, MEDICINE 70,670
32Ásgerður; Theodore,
Christine; Feyerabend,
Susan; Helissey, Carole;
Ozatilgan, Ayse; Geffriaud-
Ricouard, Christine;
Castellano, Daniel; CARD
Investigators
Cohen, Paul A; Jhingran,
Anjua; OAKNIN
12/01/201 Cervical Revie BENZAQUEN, ANA
9 cancer w MAZALTOB; Denny, Lynette LANCET 59,102
Chronic
lymphocytic
leukaemia: BOSCH ALBAREDA, NATURE REVIEWS
01/11/201 from genetics Revie FRANCESC; Dalla-Favera, CLINICAL
9 to treatment w Riccardo ONCOLOGY 34,106
Powles, Thomas; Kockx,
Mark; Rodriguez-Vida, Alejo;
Duran, Ignacio; Crabb,
Simon J; Van Der Heijden,
Michiel S; Szabados,
Bernadett; Pous, Albert
Font; Gravis, Gwenaelle;
Clinical Herranz, Urbano Anido;
efficacy and Protheroe, Andrew; Ravaud,
biomarker Alain; Maillet, Denis;
analysis of Mendez, Maria Jose;
neoadjuvant SUAREZ RODRIGUEZ,
atezolizumab CRISTINA; Linch, Mark;
in operable Prendergast, Aaron; van
urothelial Dam, Pieter-Jan; Stanoeva,
carcinoma in Diana; Daelemans, Sofie;
01/11/201 the ABACUS Mariathasan, Sanjeev; Tea, NATURE
9 trial Article Joy S; Mousa, Kelly; MEDICINE 30,641
33Banchereau, Romain;
Castellano, Daniel
Sharp, Adam; Welti, Jon C;
Lambros, Maryou B K;
Dolling, David; Rodrigues,
Daniel Nava; Pope, Lorna;
Aversa, Caterina;
Figueiredo, Ines; Fraser,
Jennifer; Ahmad, Zai; Lu,
Changxue; Rescigno,
Pasquale; Kolinsky, Michael;
Bertan, Claudia; Seed,
George; Riisnaes, Ruth;
Miranda, Susana; Crespo,
Mateus; Pereira, Rita;
Clinical Utility Ferreira, Ana; Fowler,
of Circulating Gemma; Ebbs, Berni; Flohr,
Tumour Cell Penny; Neeb, Antje;
Androgen Bianchini, Diletta;
Receptor Petremolo, Antonella;
Splice Variant- Sumanasuriya, Semini;
7 Status in Paschalis, Alec; MATEO
Metastatic VALDERRAMA, JOAQUIN;
Castration- Tunariu, Nina; Yuan, Wei;
resistant Carreira, Suzanne; Plymate,
01/11/201 Prostate Stephen R; Luo, Jun; de EUROPEAN
9 Cancer Article Bono, Johann S UROLOGY 17,298
Comparative Cherny, Nathan I; de Vries,
Assessment of Elisabeth G E; Dafni,
Clinical Benefit Urania; Garrett-Mayer,
Using the Elizabeth; McKernin,
ESMO- Shannon E; Piccart, Martine; JOURNAL OF
01/02/201 Magnitude of Latino, Nicola J; Douillard, CLINICAL
9 Clinical Benefit Article Jean-Yves; Schnipper, ONCOLOGY 28,245
34Scale Version Lowell E; Somerfield, Mark
1.1 and the R; Bogaerts, Jan; Karlis,
ASCO Value Dimitris; Zygoura,
Framework Panagiota; Vervita, Katerina;
Net Health Pentheroudakis, George;
Benefit Score TABERNERO CATURLA,
JOSEP; Zielinski, Christoph;
Wollins, Dana S; Schilsky,
Richard L
Baliakas, Panagiotis;
Jeromin, Sabine; Iskas,
Michalis; Puiggros, Anna;
Plevova, Karla;
NguyenKhac, Florence;
Davis, Zadie; Rigolin, Gian
Matteo; Visentin, Andrea;
Xochelli, Aliki; Delgado,
Julio; Baran-Marszak,
Fanny; Stalika, Evaggelia;
ABRISQUETA COSTA,
PAU; Durechova, Kristina;
Papaioannou, George;
Eclache, Virginie; Dimou,
Maria; Iliakis, Theodoros;
Collado, Rosa; Doubek,
Cytogenetic Michael; Calasanz, M Jose;
complexity in Ruiz-Xiville, Neus; Moreno,
chronic Carolina; Jarosova, Marie;
lymphocytic Leeksma, Alexander C;
leukemia: Panayiotidis, Panayiotis;
definitions, Podgornik, Helena;
associations, Cymbalista, Florence;
14/03/201 and clinical Anagnostopoulos, Achilles;
9 impact. Article Trentin, Livio; Stavroyianni, BLOOD 16,562
35Niki; Davi, Fred; Ghia,
Paolo; Kater, Arnon P;
Cuneo, Antonio;
Pospisilova, Sarka; Espinet,
Blanca; Athanasiadou,
Anastasia; Oscier, David;
Haferlach, Claudia;
Stamatopoulos, Kostas
Fizazi, Karim; Shore, Neal;
Tammela, Teuvo L; Ulys,
Albertas; Vjaters, Egils;
Polyakov, Sergey; Jievaltas,
Mindaugas; Luz, Murilo;
Alekseev, Boris; Kuss, Iris;
Kappeler, Christian; Snapir,
Amir; Sarapohja, Toni;
Smith, Matthew R; ARAMIS
Investigators; Metrebian,
Sergio; Montes de Oca, Luis
Fernando; Richardet, Martin;
Dowling, Anthony; Hovey,
Elizabeth; Joshi, Abishek;
Krieger, Laurence; Oliveira,
Niara; Parnis, Francis;
Meran, Johannes; Shariat,
Shahrokh; Gedrevich,
Zigmund; Polyakov, Sergey;
Darolutamide Forget, Frederic; Waltregny,
in David; Werbrouck, Patrick;
Nonmetastatic, Wynendaele, Wim; Alves da
Castration- Silva, Bruno S; Andrade,
Resistant Livia; Bastos, Diogo Assed; NEW ENGLAND
28/03/201 Prostate Beato, Carlos Augusto; JOURNAL OF
9 Cancer. Article Borges, Giuliano S; Cruz, MEDICINE 70,670
36Felipe J; De Arruda, Larissa
M; do Reis, Rodolfo; Eyll,
Brigitte M; Lago, Sergio;
Lazaretti, Nicolas; Luz,
Murilo; Mavignier Carcano,
Flavio; Murad, Andre
Marcio; Paula, Adriano P;
Pires, Luis A; Rios, Luis;
Silveira, Glauco C; Zereu,
Manuela; Mladenov, Dimitar;
Stamboliyski, Vesselin;
Chin, Joseph; Emmenegger,
Urban; Fleshner, Neil; Gotto,
Geoffrey; Jacobson, Avrum;
Jansz, Kenneth G;
Ouellette, Paul; Rendon,
Ricardo; Siemens, Robert;
Correa, Jose Jaime;
Lobaton Ramirez, Jose
Fernando; Rey, Milton
Salazar; Capoun, Otakar;
Heracek, Jiri; Jandeisek,
Jan; Krolupper, Marek;
Matouskova, Michaela;
Vseticka, Jaroslav; Pokker,
Helis; Hirvonen, Outi;
Marttila, Timo; Rannikko,
Antti; Tammela, Teuvo;
Azria, David; Azzouzi,
Abdel-Rahmene;
Cathelineau, Xavier; Coloby,
Patrick; Culine, Stephane;
de la Taille, Alexandre;
Dourthe, Louis-Marie;
37Eymard, Jean-Christophe;
Fizazi, Karim; Mouillet,
Guillaume; Haillot, Olivier;
Helissey, Carole; Lagneau,
Edouard; Lebret, Thierry;
Mahammedi, Hakim; Pfister,
Christian; Rigaud, Jerome;
Rotarski, Maciej; Roubaud,
Guilhem; Ruffion, Alain;
Spaeth, Dominique; Tourani,
Jean-Marc; Vincendeau,
Sebastien; Banek, Severine;
Binder, Manfred; Bogemann,
Martin; Carl, Stefan;
Feyerabend, Susan;
Gleissner, Jochen;
Heinemann, Volker; Maier,
Simone; Niegisch, Guenter;
Rudolph, Robert; Schmitz-
Drager, Bernd; Schneider,
Tim; Schostak, Martin;
Stenzl, Arnuf; Stroelin,
Petra; Thomas, Christian;
Warnack, Wolfgang; Wiegl,
Armin; Wirth, Manfred; Ali,
Tarek; Arkosy, Peter; Beli,
Laszlo; Csoszi, Tibor;
Nyirady, Peter; Pajor,
Laszlo; Szabo, Attila;
Torzsok, Ferenc; Toth,
Zoltan; Grikshats, Eduard;
Aglietta, Massimo; Damiano,
Rocco; Facchini, Gaetano;
Gasparro, Donatello;
38Mucciardi, Giuseppe; Natoli,
Clara; Sabbatini, Roberto;
Scagliotti, Giorgio V;
Schepisi, Giuseppe;
Serretta, Vincenzo; Anai,
Satoshi; Asano, Kosuke;
Ebara, Shin; Fukasawa,
Satoshi; Fukaya, Yasuo;
Hirata, Akio; Iinuma,
Masahiro; Kasuya, Yutaka;
Kato, Masashi; Kawakita,
Mutsushi; Kitamura, Hiroshi;
Kobayashi, Kazuki; Kondo,
Yukihiro; Masumori, Naoya;
Matsubara, Nobuaki;
Matsumoto, Hiroaki;
Matsushima, Hisashi; Miki,
Kenta; Mizusawa, Hiroya;
Momma, Tetsuo; Motoyama,
Daisuke; Miyagi, Tohru;
Nagata, Masayoshi;
Namima, Takashige;
Nishimatsu, Hiroaki;
Nishimura, Kazuo; Noguchi,
Masanori; Okegawa,
Takatsugu; Oya, Mototsugu;
Sakai, Hideki; Shin,
Toshitaka; Suzuki, Kazuhiro;
Tabata, Kenichi; Takamoto,
Atsushi; Tamada, Satoshi;
Tobe, Toyofusa; Tsurusaki,
Toshifumi; Uemura, Hiroji;
Uemura, Hirotsugu;
Ukimura, Osamu;
39Yamaguchi, Seiji; Buldinskis,
Guntis; Hublarovs, Olegs;
Laukmanis, Alvis; Lietuvietis,
Vilnis; Litavniece, Dzintra;
Vjaters, Egils; Auskalnis,
Stasys; Jievaltas,
Mindaugas; Ramonas,
Henrikas; Ulys, Albertas;
Venckus, Raimundas; Abrill
Mendoza, Giovanna
Victoria; Alarcon-Rozas,
Ashley Efrain; Aleman
Polanco, Diana Sofia; Philco
Salas, Manuel Jesus;
Badzio, Andrzej; Kmieciak,
Rafal; Majek, Antoni;
Marcheluk, Adam; Mruk,
Andrzej; Niezabitowski,
Jacek; Senkus-Konefka,
Elzbieta; Nyk, Lukasz;
Skoneczna, Iwona A;
Wiechno, Pawel; Campos
Pinheiro, Luis; Faustino,
Ilda; Fonseca, Jorge; Lima,
Estevao; Marialva, Celso;
Mauricio, Joaquina; Pina,
Francisco; Prisco, Rui;
Rodrigues, Tania; Silva,
Eduardo; Bumbu,
Gheorghe; Cauni, Victor;
Cebotaru, Cristina L;
Chibelean, Bogdan Calin;
Dinu, Marius; Ghizdavescu,
Gabriel Doru; Harza, Mihai;
40Jinga, Viorel; Lungulescu,
Dan S; Schenker, Michael;
Al-Shukri, Salman H;
Alekseev, Boris; Alyasova,
Anna; Apolikhin, Oleg;
Buiniakova, Anna; Dykhno,
Yury; Fomkin, Roman;
Ivanov, Sergey;
Khvorostenko, Denis;
Kogan, Mikhail; Kopyltsov,
Evgeny; Lykov, Alexander;
Pimenov, Igor; Rodicheva,
Natalia; Safina, Sufia Z;
Semenov, Andrey; Shirinkin,
Vadim B; Vladimirov,
Vladimir; Zavyalov, Mikhail;
Filipovic, Zoran; Stojanovic,
Vesna; Breza, Jan;
Goncalves, Frederico;
Sokol, Roman; Ackermann,
Hilgard; Coetzee, Lance;
Harris, Jill K; Kraus, Peter;
Lazarus, John; Chung,
Byung Ha; Hong, Sung
Joon; Kang, Taek Won; Kim,
Choung-Soo; Kim, Chun Il;
Kim, Saewoong; Kim, Wun-
Jae; Kwak, Cheol; Kwon,
Tae-Gyun; Seo, Seong Il;
Yoon, Sang Jin; Alvarez-
Ossorio, Jose; Benejam,
Jose Maria; CARLES
GALCERAN, JOAN; Casas
Nebra, Francisco Javier;
41Garcio-Rojo, Dario; Garde
Noguera, Javier; Gomez
Veiga, Francisco; Gomez-
Ferrer, Alvaro; Gonzalez Del
Alba, Aranzazu; Gonzalez
Enguita, Carmen;
Hernandez Fernandez,
Carlos; Guijarro Gil, Jesus;
Juarez, Alvaro; Jurado, Jose
Miguel; Llorente Abarca,
Carlos; Loizaga, Ana;
Medina Lopez, Rafael
Antonio; Mendez Vidal,
Maria Jose; Pinto Marin,
Alvaro; Puente Vazquez,
Javier; Ribal Caparros,
Maria Jose; Rodriguez
Antolin, Alfredo; Saez
Medina, Maribel; Suarez,
Jose F; Virizuela, Juan
Antonio; Andren, Ove;
Damber, Jan-Erik;
Haggman, Michael;
Hellstrom, Magnus; Chen,
Chung-Hsin; Huang, Shu-
Pin; Pang, See-Tong; Wu,
Tong-Lin; Yang, Cheng-
Kuang; Esen, Adil;
Muezzinoglu, Talha; Ozyurt,
Ceyhun; Sozen, Tevfik
Sinan; Yildirim, Asif;
Adamchuk, Hryhoriy;
Antonyan, Igor;
Bondarenko, Ihor;
42Grygorenko, Viacheslav;
Ivashchenko, Petro; Rusyn,
Andriy; Sagan, Olexiy;
Zaitsev, Valerii; Beesley,
Sharon; Beresford, Mark;
Birtle, Alison; Bryan,
Nicolas; Dixit, Sanjay;
Jones, Robert; Kanaga
Sundaram, Subramanian;
Koh, Pek; Kynaston,
Howard; Madaan, Sanjeev;
Ng, Yeung; Rogers, Paul;
Syndikus, Isabel; Vengalil,
Salil; Agamah, Edem;
Albany, Costantine; Aragon-
Ching, Jeanny; Aronson,
William J; Bailen, James;
Belkoff, Laurence;
Bernstein, Guy; Bidair,
Mohamed; Bowles, Daniel
W; Brown, Gordon; Cinman,
Arnold; Clark, Randil L;
Clark, William; Cohen, Todd;
Cookson, Michael;
Deguenther, Mark; El Ayass,
Walid; Brede, Christopher
M; Franks, Michael; Gabrail,
Nashat Y; Gartrell,
Benjamin; Given, Robert W;
Karsh, Lawrence; Koletsky,
Alan; Korman, Howard;
Martin, Benjamin; Matrana,
Marc; Merrick, Gregory;
Millard, Frederick E; Morris,
43David; Moss, Robert A;
Nordquist, Luke; Ornstein,
Moshe; Patel, Kalpesh;
Pieczonka, Christopher;
Pliskin, Marc J; Rivera,
Inoel; Rosenberg, Steven J;
Schwab, William C; Sharifi,
Roohollah; Shevrin, Daniel;
Shore, Neal; Smith,
Matthew; Taksey, Jason;
Tebyani, Neyssan; Thara,
Eddie; Tolia, Bhupendra M;
Trainer, Andrew F; Tutrone,
Ronald F; Wertheim,
Michael S
Effect of
Aflibercept
Plus Modified Fernández-Martos, Carlos;
FOLFOX6 Pericay, Carles; Losa,
Induction Ferran; García-Carbonero,
Chemotherapy Rocio; Layos, Laura;
Before Rodríguez-Salas, Nuria;
Standard Martin-Richard, Marta;
Chemoradioth Alonso-Orduña, Vicente;
erapy and Vera, Ruth; Gallego, Javier;
Surgery in CAPDEVILA CASTILLON,
Patients With JAUME; Salud, Antonieta;
High-Risk Nogué, Miquel; Maurel,
Rectal Joan; Guash, Inmaculada;
Adenocarcino Montagut, Clara; Lopez,
ma: The Carlos; Macias, Ismael;
01/01/201 GEMCAD Jain, Rakesh K; Garcia-
9 1402 Article Albeniz, Xabier JAMA oncology 22,416
44Randomized
Clinical Trial.
Kopetz, Scott; Grothey, Axel;
Yaeger, Rona; Van Cutsem,
Eric; Desai, Jayesh;
Yoshino, Takayuki; Wasan,
Harpreet; Ciardiello,
Fortunato; Loupakis, Fotios;
Hong, Yong Sang; Steeghs,
Neeltje; Guren, Tormod K;
Arkenau, Hendrik-Tobias;
Garcia-Alfonso, Pilar;
Pfeiffer, Per; Orlov, Sergey;
Lonardi, Sara; ELEZ
FERNANDEZ, MARIA
ELENA; Kim, Tae-Won;
Schellens, Jan H M; Guo,
Christina; Krishnan, Asha;
Dekervel, Jeroen; Morris,
Van; Calvo Ferrandiz,
Aitana; Tarpgaard, L S;
Encorafenib, Braun, Michael; Gollerkeri,
Binimetinib, Ashwin; Keir, Christopher;
and Cetuximab Maharry, Kati; Pickard,
in BRAF Michael; Christy-Bittel,
V600E- Janna; Anderson, Lisa;
Mutated Sandor, Victor; NEW ENGLAND
24/10/201 Colorectal TABERNERO CATURLA, JOURNAL OF
9 Cancer Article JOSEP MEDICINE 70,670
Epigenetic loss Janin, Maxime; Ortiz-
of RNA- Barahona, Vanessa; de
methyltransfer Moura, Manuel Castro; ACTA
01/12/201 ase NSUN5 in Martínez-Cardús, Anna; NEUROPATHOLOG
9 glioma targets Article Llinàs-Arias, Pere; Soler, ICA 18,174
45ribosomes to Marta; Nachmani, Daphna;
drive a stress Pelletier, Joffrey; Schumann,
adaptive Ulrike; Calleja-Cervantes,
translational Maria E; Moran, Sebastian;
program Guil, Sonia; Bueno-Costa,
Alberto; Piñeyro, David;
Perez-Salvia, Montserrat;
Rosselló-Tortella, Margalida;
Piqué, Laia; Bech-Serra,
Joan J; De La Torre,
Carolina; Vidal, August;
Martínez-Iniesta, María;
Martín-Tejera, Juan F;
Villanueva, Alberto; ARIAS
PIÑEIRO, ALEXANDRA;
CUARTAS MAZA, Mª
ISABEL; Aransay, Ana M; La
Madrid, Andres Morales;
Carcaboso, Angel M; Santa-
Maria, Vicente; Mora,
Jaume; Fernandez, Agustin
F; Fraga, Mario F; Aldecoa,
Iban; Pedrosa, Leire; Graus,
Francesc; Vidal, Noemi;
Martínez-Soler, Fina;
Tortosa, Avelina; Carrato,
Cristina; Balañá, Carme;
Boudreau, Matthew W;
Hergenrother, Paul J; Kötter,
Peter; Entian, Karl-Dieter;
Hench, Jürgen; Frank,
Stephan; Mansouri, Sheila;
Zadeh, Gelareh; Dans,
Pablo D; Orozco, Modesto;
46Thomas, George; Blanco,
Sandra; SEOANE SUAREZ,
JOAN; Preiss, Thomas;
Pandolfi, Pier Paolo;
Esteller, Manel
Loriot, Yohann; Necchi,
Andrea; Park, Se Hoon;
Garcia-Donas, Jesus;
Huddart, Robert; Burgess,
Earle; Fleming, Mark;
Rezazadeh, Arash; Mellado,
Begoña; Varlamov, Sergey;
Joshi, Monika; Duran,
Ignacio; Tagawa, Scott T;
Zakharia, Yousef; Zhong,
Bob; Stuyckens, Kim;
Santiago-Walker, Ademi; De
Porre, Peter; O'Hagan,
Anne; Avadhani, Anjali;
Siefker-Radtke, Arlene O;
BLC2001 Study Group;
Loidl, Wolfgang; Meran,
Johannes; Shariat,
Shahrokh; Stöger, Herbert;
Decaestecker, Karel; Dirix,
Luc; Machiels, Jean Pascal;
Schatteman, Peter;
Verschaeve, Vincent;
Erdafitinib in Borchiellini, Delphine;
Locally Culine, Stephane; Delva,
Advanced or Remy; Flechon, Aude;
Metastatic Gross Goupil, Marine; NEW ENGLAND
25/07/201 Urothelial Houédé, Nadine; Joly, JOURNAL OF
9 Carcinoma. Article Florence; Loriot, Yohann; MEDICINE 70,670
47Rolland, Frederic; Théodore,
Christine; Vano, Yann;
Zanetta, Sylvie; Bögemann,
Martin; Goebell, Peter;
Hadaschik, Boris; Imkamp,
Florian; Klotz, Theodor;
Krege, Susanne; Manos,
Dimitrios; May, Matthias;
Retz, Margitta; Schultze-
Seemann, Wolfgang;
Strauss, Arne; Wülfing,
Christian; Zimmermann,
Uwe; Gez, Eliahu; Keizman,
Daniel; Peer, Avivit;
Rosenbaum, Eli; Rouvinov,
Keren; Sella, Avishai; Airoldi,
Mario; Barone, Carlo;
Basso, Umberto; Berardi,
Rossana; Bracarda, Sergio;
Cortesi, Enrico; De Giorgi,
Ugo; Facchini, Gaetano;
Galli, Luca; Gasparro,
Donatello; Mosca,
Alessandra; Necchi, Andrea;
Santoro, Armando;
Scagliotti, Giorgio;
Sternberg, Cora Nanette;
Lee, Hyo Jin; Lee, Jae-Lyun;
Park, Se Hoon; Rha, Sun
Young; Seo, Ho Kyung;
Shin, Dong Bok; Bulat, Iurie;
Cebotaru, Cristina; Jinga,
Viorel; Lungulescu, Dan;
Marinca, Mihai; Alexeev,
48Boris; Izmailov, Adel;
Khvorostenko, Denis;
Kopyltsov, Eugeniy;
Matveev, Vsevolod;
Shkolnik, Mikhail; Varlamov,
Sergey; Vladimirov,
Vladimir; Arranz, José
Ángel; CARLES
GALCERAN, JOAN; Duran,
Ignacio; Font, Albert; Garcia-
Donas, Jesus; Mellado,
Begoña; Moreno, Victor;
Perez Gracia, Jose Luis;
Pinto, Alvaro; Saez, Maribel;
Lin, Chia Chi; Ou, Yen
Chuan; Pang, See Tong; Su,
Wen Pin; Gibbs, Stephanie;
Huddart, Robert; Hussain,
Syed; Niblock, Patrick;
Parikh, Omi; Pascoe, Sarah;
Sarwar, Naveed; Burgess,
Earle; Burke, John; Chamie,
Karim; Dawson, Nancy;
Doshi, Gurjyot; Fleming,
Mark; Hainsworth, John;
Jain, Sharad; Joshi, Monika;
Larson, Tim; McIntyre, Kristi;
O'Donnell, Peter; Pan,
Chong-Xian; Parikh, Rahul;
Rezazadeh, Arash; Savage,
Alison; Schnadig, Ian;
Shore, Neal; Siefker-Radtke,
Arlene; Srinivas, Sandy;
49Tagawa, Scott; Vogelzang,
Nicholas; Zakharia, Yousef
Cherny, Nathan I;
ESMO-MCBS: TABERNERO CATURLA,
01/04/201 setting the JOSEP; de Vries, Elisabeth LANCET
9 record straight Letter GE ONCOLOGY 35,386
Kim, Richard D; Sarker,
Debashis; Meyer, Tim; Yau,
Thomas; MACARULLA
MERCADE, TERESA; Park,
Joong-Won; Choo, Su Pin;
Hollebecque, Antoine; Sung,
Max W; Lim, Ho-Yeong;
Mazzaferro, Vincenzo;
Trojan, Joerg; Zhu, Andrew
X; Yoon, Jung-Hwan;
Sharma, Sunil; Lin, Zhong-
Zhe; Chan, Stephen L;
Faivre, Sandrine; Feun,
Lynn G; Yen, Chia-Jui;
First-in-Human Dufour, Jean-Francois;
Phase I Study Palmer, Daniel H; Llovet,
of Fisogatinib Josep M; Manoogian,
(BLU-554) Melissa; Tugnait, Meera;
Validates Stransky, Nicolas; Hagel,
Aberrant Margit; Kohl, Nancy E;
FGF19 Lengauer, Christoph;
Signaling as a Sherwin, Cori Ann; Schmidt-
Driver Event in Kittler, Oleg; Hoeflich, Klaus
01/12/201 Hepatocellular P; Shi, Hongliang; Wolf, CANCER
9 Carcinoma Article Beni B; Kang, Yoon-Koo DISCOVERY 26,370
Five-Year Garon, Edward B; Hellmann, JOURNAL OF
01/10/201 Overall Matthew D; Rizvi, Naiyer A; CLINICAL
9 Survival for Article Carcereny, Enric; Leighl, ONCOLOGY 28,245
50Patients With Natasha B; Ahn, Myung-Ju;
Advanced Eder, Joseph Paul;
Non-Small-Cell Balmanoukian, Ani S;
Lung Cancer Aggarwal, Charu; Horn,
Treated With Leora; Patnaik, Amita;
Pembrolizuma Gubens, Matthew;
b: Results Ramalingam, Suresh S;
From the FELIP FONT, ENRIQUETA;
Phase I Goldman, Jonathan W;
KEYNOTE- Scalzo, Cathie; Jensen,
001 Study Erin; Kush, Debra A; Hui,
Rina
Schmid, Peter; Zaiss,
Matthias; Harper-Wynne,
Catherine; Ferreira, Marta;
Dubey, Sidharth; Chan,
Fulvestrant Stephen; Makris, Andreas;
Plus Nemsadze, Gia; Brunt,
Vistusertib vs Adrian M; Kuemmel,
Fulvestrant Sherko; Ruiz, Isabel;
Plus Perelló, Antonia; Kendall,
Everolimus vs Anne; Brown, Janet;
Fulvestrant Kristeleit, Hartmut;
Alone for Conibear, John; SAURA
Women With MANICH, CRISTINA;
Hormone Grenier, Julien; Máhr,
Receptor- Károly; Schenker, Michael;
Positive Sohn, Joohyuk; Lee, Keun
Metastatic Seok; Shepherd,
Breast Cancer: Christopher J; Oelmann,
The MANTA Elisabeth; Sarker, Shah-
Phase 2 Jalal; Prendergast, Aaron;
01/01/201 Randomized Marosics, Patricia; Moosa,
9 Clinical Trial. Article Atiyyah; Lawrence, Cheryl; JAMA oncology 22,416
51Coetzee, Carike; Mousa,
Kelly; CORTES CASTAN,
JAVIER
Zafeiriou, Zafeiris; Bianchini,
Diletta; Chandler, Robert;
Rescigno, Pasquale; Yuan,
Genomic Wei; Carreira, Suzanne;
Analysis of Barrero, Maialen;
Three Petremolo, Antonella;
Metastatic Miranda, Susana; Riisnaes,
Prostate Ruth; Rodrigues, Daniel
Cancer Nava; Gurel, Bora;
Patients with Sumanasuriya, Semini;
Exceptional Paschalis, Alec; Sharp,
Responses to Adam; MATEO
Carboplatin VALDERRAMA, JOAQUIN;
Indicating Tunariu, Nina; Chinnaiyan,
Different Types Arul M; Pritchard, Colin C;
01/01/201 of DNA Repair Kelly, Kevin; de Bono, EUROPEAN
9 Deficiency Article Johann S UROLOGY 17,298
RODON AHNERT, JORDI;
Soria, Jean-Charles; Berger,
Raanan; Miller, Wilson H;
Rubin, Eitan; Kugel,
Aleksandra; Tsimberidou,
Apostolia; Saintigny, Pierre;
Genomic and Ackerstein, Aliza; BRAÑA
transcriptomic GARCIA, IRENE; Loriot,
profiling Yohann; Afshar,
expands Mohammad; Miller, Vincent;
precision Wunder, Fanny; Bresson,
cancer Catherine; Martini, Jean-
01/05/201 medicine: the François; Raynaud, NATURE
9 WINTHER trial Article Jacques; Mendelsohn, MEDICINE 30,641
52John; Batist, Gerald; Onn,
Amir; TABERNERO
CATURLA, JOSEP;
Schilsky, Richard L; Lazar,
Vladimir; Lee, J Jack;
Kurzrock, Razelle
Page, Elizabeth C; Bancroft,
Elizabeth K; Brook, Mark N;
Assel, Melissa; Hassan Al
Battat, Mona; Thomas,
Sarah; Taylor, Natalie;
Chamberlain, Anthony;
Pope, Jennifer; Raghallaigh,
Holly Ni; Evans, D Gareth;
Rothwell, Jeanette; Maehle,
Lovise; Grindedal, Eli Marie;
James, Paul; Mascarenhas,
Lyon; McKinley, Joanne;
Side, Lucy; Thomas, Tessy;
van Asperen, Christi; Vasen,
Hans; Kiemeney, Lambertus
A; Ringelberg, Janneke;
Interim Results Jensen, Thomas Dyrsø;
from the Osther, Palle J S; Helfand,
IMPACT Brian T; Genova, Elena;
Study: Oldenburg, Rogier A;
Evidence for Cybulski, Cezary;
Prostate- Wokolorczyk, Dominika;
specific Ong, Kai-Ren; Huber,
Antigen Camilla; Lam, Jimmy; Taylor,
Screening in Louise; Salinas, Monica;
BRCA2 Feliubadaló, Lidia;
01/12/201 Mutation Oosterwijk, Jan C; van EUROPEAN
9 Carriers. Article Zelst-Stams, Wendy; Cook, UROLOGY 17,298
53Jackie; Rosario, Derek J;
Domchek, Susan; Powers,
Jacquelyn; Buys, Saundra;
O'Toole, Karen; Ausems,
Margreet G E M;
Schmutzler, Rita K; Rhiem,
Kerstin; Izatt, Louise;
Tripathi, Vishakha; Teixeira,
Manuel R; Cardoso, Marta;
Foulkes, William D; Aprikian,
Armen; van Randeraad,
Heleen; Davidson,
Rosemarie; Longmuir, Mark;
Ruijs, Mariëlle W G;
Helderman van den Enden,
Apollonia T J M; Adank,
Muriel; Williams, Rachel;
Andrews, Lesley; Murphy,
Declan G; Halliday, Dorothy;
Walker, Lisa; Liljegren,
Annelie; Carlsson, Stefan;
Azzabi, Ashraf; Jobson,
Irene; Morton, Catherine;
Shackleton, Kylie; Snape,
Katie; Hanson, Helen;
Harris, Marion; Tischkowitz,
Marc; Taylor, Amy; Kirk,
Judy; Susman, Rachel;
Chen-Shtoyerman, Rakefet;
Spigelman, Allan; Pachter,
Nicholas; Ahmed, Munaza;
Ramon Y Cajal, Teresa;
Zgajnar, Janez; Brewer,
Carole; GADEA, NEUS;
54Brady, Angela F; van Os,
Theo; Gallagher, David;
Johannsson, Oskar;
Donaldson, Alan; Barwell,
Julian; Nicolai, Nicola;
Friedman, Eitan; Obeid,
Elias; Greenhalgh, Lynn;
Murthy, Vedang; Copakova,
Lucia; Saya, Sibel; McGrath,
John; Cooke, Peter;
Rønlund, Karina;
Richardson, Kate;
Henderson, Alex; Teo, Soo
H; Arun, Banu; Kast, Karin;
Dias, Alexander; Aaronson,
Neil K; Ardern-Jones,
Audrey; Bangma, Chris H;
Castro, Elena; Dearnaley,
David; Eccles, Diana M;
Tricker, Karen; Eyfjord,
Jorunn; Falconer, Alison;
Foster, Christopher;
Gronberg, Henrik; Hamdy,
Freddie C; Stefansdottir,
Vigdis; Khoo, Vincent;
Lindeman, Geoffrey J;
Lubinski, Jan; Axcrona,
Karol; Mikropoulos,
Christos; Mitra, Anita;
Moynihan, Clare; Rennert,
Gadi; Suri, Mohnish; Wilson,
Penny; Dudderidge, Tim;
IMPACT Study
Collaborators; Offman,
55Judith; Kote-Jarai, Zsofia;
Vickers, Andrew; Lilja, Hans;
Eeles, Rosalind A
Etxeberria, Iñaki; Bolaños,
Elixabet; Quetglas, Jose I;
GROS VIDAL, ALENA;
Villanueva, Alberto;
Palomero, Jara; Sánchez-
Paulete, Alfonso R; Piulats,
Jose María; Matias-Guiu,
Xavier; Olivera, Irene;
Ochoa, Maria C; Labiano,
Sara; Garasa, Saray;
Rodriguez, Inmaculada;
Vidal, August; Mancheño,
Intratumor Uxua; Hervás-Stubbs,
Adoptive Sandra; Azpilikueta,
Transfer of IL- Arantza; Otano, Itziar;
12 mRNA Aznar, M Angela;
Transiently Sanmamed, Miguel F;
Engineered Inogés, Susana; Berraondo,
09/12/201 Antitumor CD8 Pedro; Teijeira, Álvaro;
9 + T Cells. Article Melero, Ignacio CANCER CELL 23,916
BEAULIEU, MARIE-EVE;
JAUSET GONZALEZ,
ANTONIO; MASSO
Intrinsic cell- VALLES, DANIEL;
penetrating MARTINEZ MARTI,
activity propels SANDRA; Rahl, Peter;
Omomyc from Maltais, Loïka; ZACARIAS
proof of FLUCK, MARIANO
concept to FEDERICO; SCIENCE
20/03/201 viable anti- CASACUBERTA SERRA, TRANSLATIONAL
9 MYC therapy Article SILVIA; SERRANO DEL MEDICINE 17,161
56POZO, ERIKA; Fiore,
Christopher; Foradada, Laia;
Cano, Virginia Castillo;
Sánchez-Hervás, Meritxell;
Guenther, Matthew; Romero
Sanz, Eduardo; Oteo, Marta;
Tremblay, Cynthia; Martín,
Génesis; Letourneau,
Danny; Montagne, Martin;
Morcillo Alonso, Miguel
Ángel; WHITFIELD,
JONATHAN RICHARD;
Lavigne, Pierre; SOUCEK,
LAURA
Emens, Leisha A; CRUZ
Long-term ZAMBRANO, CRISTINA;
Clinical Eder, Joseph Paul; Braiteh,
Outcomes and Fadi; Chung, Cathie;
Biomarker Tolaney, Sara M; Kuter,
Analyses of Irene; Nanda, Rita; Cassier,
Atezolizumab Philippe A; Delord, Jean-
Therapy for Pierre; Gordon, Michael S;
Patients With ElGabry, Ehab; Chang,
Metastatic Ching-Wei; Sarkar, Indrani;
Triple-Negative Grossman, William; O'Hear,
Breast Cancer Carol; Fassò, Marcella;
01/01/201 A Phase 1 Molinero, Luciana; Schmid,
9 Study Article Peter JAMA oncology 22,416
Regev, Aviv; Zhang, Feng;
Looking Jaffee, Elizabeth; Farrar,
forward 25 Jeremy; Nkengasong, John;
years: the Topol, Eric; Partridge, Linda;
01/12/201 future of News Mundel, Trevor; NATURE
9 medicine Item TABERNERO CATURLA, MEDICINE 30,641
57JOSEP; Sabeti, Pardis;
Toreele, Els
Maintenance
Defactinib
Versus
Placebo After
First-Line Fennell, Dean A.; Baas,
Chemotherapy Paul; Taylor, Paul; Nowak,
in Patients Anna K.; Gilligan, David;
With Merlin- Nakano, Takashi; Pachter,
Stratified Jonathan A.; Weaver, David
Pleural T.; Scherpereel, Arnaud;
Mesothelioma: Pavlakis, Nick; van
COMMAND-A Meerbeeck, Jan P.;
Double-Blind, CEDRES PEREZ, SUSANA; JOURNAL OF
01/04/201 Randomized, Nolan, Luke; Kindler, Hedy; CLINICAL
9 Phase II Study Article Aerts, Joachim G. J. V. ONCOLOGY 28,245
Golan, Talia; Hammel,
Pascal; Reni, Michele; Van
Cutsem, Eric; MACARULLA
MERCADE, TERESA; Hall,
Michael J; Park, Joon-Oh;
Hochhauser, Daniel; Arnold,
Dirk; Oh, Do-Youn;
Maintenance Reinacher-Schick, Anke;
Olaparib for Tortora, Giampaolo; Algül,
Germline Hana; O'Reilly, Eileen M;
BRCA-Mutated McGuinness, David; Cui,
Metastatic Karen Y; Schlienger, Katia; NEW ENGLAND
25/07/201 Pancreatic Locker, Gershon Y; Kindler, JOURNAL OF
9 Cancer Article Hedy L MEDICINE 70,670
Managing MATEO VALDERRAMA,
01/02/201 Nonmetastatic Revie JOAQUIN; Fizazi, Karim; EUROPEAN
9 Castration- w Gillessen, Silke; UROLOGY 17,298
58resistant Heidenreich, Axel; PEREZ
Prostate LOPEZ, RAQUEL; Oyen,
Cancer Wim J G; Shore, Neal;
Smith, Matthew; Sweeney,
Christopher; Tombal,
Bertrand; Tomlins, Scott A;
de Bono, Johann S
Mosunetuzum
ab Induces
Complete
Remissions in
Poor
Prognosis
Non-Hodgkin
Lymphoma
Patients,
Including
Those Who
Are Resistant
to or Relapsing Schuster, S.J.; Bartlett, N.L.;
After Chimeric Assouline, S.; Yoon, S.-S.;
Antigen BOSCH ALBAREDA,
Receptor T- FRANCESC; Sehn, L.H.;
Cell (CAR-T) Cheah, C.Y.; Shadman, M.;
Therapies, and Gregory, G.P.; Ku, M.; Wei,
Is Active in M.C.; Yin, S.; Kwan, A.;
Treatment Yousefi, K.; Hernandez, G.;
01/01/201 through Li, C.-C.; O'Hear, C.; Budde,
9 Multiple Lines Article L.E. BLOOD 16,562
Moving From Gourley, Charlie; BALMAÑA
Poly (ADP- GELPI, JUDITH;
Ribose) Ledermann, Jonathan A; JOURNAL OF
01/09/201 Polymerase SERRA ELIZALDE, CLINICAL
9 Inhibition to Article VIOLETA; Dent, Rebecca; ONCOLOGY 28,245
59Targeting DNA Loibl, Sibylle; Pujade-
Repair and Lauraine, Eric; Boulton,
DNA Damage Simon J
Response in
Cancer
Therapy
Bonvalot, Sylvie; Rutkowski,
Piotr L; Thariat, Juliette;
Carrère, Sébastien;
Ducassou, Anne; Sunyach,
Marie-Pierre; Agoston,
Peter; Hong, Angela;
Mervoyer, Augustin;
Rastrelli, Marco; Moreno,
Victor; Li, Rubi K; Tiangco,
NBTXR3, a Béatrice; Herraez, Antonio
first-in-class Casado; Gronchi,
radioenhancer Alessandro; Mangel, László;
hafnium oxide Sy-Ortin, Teresa;
nanoparticle, Hohenberger, Peter; de
plus Baère, Thierry; Le Cesne,
radiotherapy Axel; Helfre, Sylvie; Saada-
versus Bouzid, Esma; Borkowska,
radiotherapy Aneta; Anghel, Rodica; Co,
alone in Ann; Gebhart, Michael;
patients with Kantor, Guy; Montero,
locally Angel; Loong, Herbert H;
advanced soft- VERGES CAPDEVILA,
tissue sarcoma RAMONA; Lapeire, Lore;
(Act. In. Sarc): Dema, Sorin; Kacso,
a multicentre, Gabriel; Austen, Lyn;
phase 2-3, Moureau-Zabotto, Laurence;
01/08/201 randomised, Servois, Vincent; LANCET
9 controlled trial Article Wardelmann, Eva; Terrier, ONCOLOGY 35,386
60Philippe; Lazar, Alexander J;
Bovée, Judith V M G; Le
Péchoux, Cécile; Papai,
Zsusanna
Scagliotti, Giorgio V; Gaafar,
Rabab; Nowak, Anna K;
Nintedanib in Nakano, Takashi; van
combination Meerbeeck, Jan; Popat,
with Sanjay; Vogelzang, Nicholas
pemetrexed J; Grosso, Federica;
and cisplatin Aboelhassan, Rasha;
for Jakopovic, Marko; Ceresoli,
chemotherapy- Giovanni L; Taylor, Paul;
naive patients Orlandi, Francisco; Fennell,
with advanced Dean A; Novello, Silvia;
malignant Scherpereel, Arnaud;
pleural Kuribayashi, Kozo;
mesothelioma CEDRES PEREZ, SUSANA;
(LUME-Meso): Sørensen, Jens Benn;
a double-blind, Pavlakis, Nick; Reck, Martin;
randomised, Velema, Derek; von
placebo- Wangenheim, Ute; Kim, LANCET
01/07/201 controlled Miyoung; Barrueco, José; RESPIRATORY
9 phase 3 trial Article Tsao, Anne S MEDICINE 22,992
González-Martín, Antonio;
Pothuri, Bhavana; Vergote,
Ignace; DePont
Niraparib in Christensen, René; Graybill,
Patients with Whitney; Mirza, Mansoor R;
Newly McCormick, Colleen;
Diagnosed Lorusso, Domenica;
Advanced Hoskins, Paul; Freyer, NEW ENGLAND
19/12/201 Ovarian Gilles; Baumann, Klaus; JOURNAL OF
9 Cancer. Article Jardon, Kris; Redondo, MEDICINE 70,670
61Andrés; Moore, Richard G;
Vulsteke, Christof;
O'Cearbhaill, Roisin E;
Lund, Bente; Backes, Floor;
Barretina-Ginesta, Pilar;
Haggerty, Ashley F; Rubio-
Pérez, Maria J; Shahin,
Mark S; Mangili, Giorgia;
Bradley, William H; Bruchim,
Ilan; Sun, Kaiming;
Malinowska, Izabela A; Li,
Yong; Gupta, Divya; Monk,
Bradley J; PRIMA/ENGOT-
OV26/GOG-3012
Investigators; Baurain, Jean-
Francois; Denys, Hannelore;
Honhon, Brigitte; Van Den
Bulck, Heidi; Han, Sileny;
Joosens, Eric; Vuylsteke,
Peter; Forget, Frederic;
Lamot, Caroline; Martinez
Mena, Corina; Peen, Ulla;
Knudsen, Anja; Maenpaa,
Johanna; Hietanen, Sakari;
Anttila, Maarit; Puistola,
Ulla; Fabbro, Michel;
Follana, Philippe; Selle,
Frederic; Joly-Lobbedez,
Florence; De La Motte
Rouge, Thibault; Berton-
Rigaud, Dominique; Abadie
Lacourtoisie, Sophie; Braicu,
Ioana; Hanf, Volker; Heitz,
Florian; Marme, Frederik;
62Schneeweiss, Andreas;
Burges, Alexander;
Schmalfeldt, Barbara;
Emons, Gunter; Calvert,
Paula M; Korach, Jacob;
Levy, Talia; Amit, Amnon;
Safra, Tamar; Artioli, Grazia;
Raspagliesi, Francesco;
Pisano, Carmela; De
Placido, Sabino; Sabbatini,
Roberto; Valabrega, Giorgio;
OAKNIN BENZAQUEN,
ANA MAZALTOB; Guerra,
Eva; Churruca, Cristina;
Bratos, Raquel; Perez, Jose;
Romero, Ignacio; Tusquets,
Ignacio; Gaba Garcia, Lydia;
Gil Martin, Marta; Calvo-
Garcia, Elisa; Manso
Sanchez, Luis; Fuentes
Pradera, Jose; Sanchez-
Heras, Ana; Yubero,
Alfonso; Romeo-Marin,
Margarita; Hellman, Kristina;
Tholander, Bengt; Cibula,
David; Rob, Lukas;
Berezovskiy, Denis;
Karthaus, Meinolf; Poka,
Robert; Pinter, Tamas;
Donnellan, Paul; Meirovitz,
Mihai; Dorum, Anne; Madry,
Radoslaw; Sikorska,
Magdalena; Podlodowska,
Justyna; Imesch, Patrick;
63Heinzelmann, Viola;
Rabaglio, Manuela; Krell,
Jon; Mcgrane, John; Badea,
Doina; Bhana, Rajanee;
Chau, Caroline; Bowen,
Rebecca; Gourley, Charlie;
Forrest, Jenny; Glasspool,
Ros; Holman, Laura;
Memarzadeh, Sanaz; Gold,
Michael; Bender, David;
Yap, Oi Wah Stephanie;
Barter, James; Callahan,
Michael; Chen, Lee-May;
Myers, Tashanna;
Disilvestro, Paul; O'Malley,
David; Ratner, Elena; Rojas,
Luis; Ghamande, Sharad;
Chalas, Eva; Chambers,
Setsuko; Zarwan, Corrine;
Chan, John; Perry, LaToya;
Zhuo, Ying; ElSahwi, Karim;
Gajewski, Walter; Lesnock,
Jamie; Moore, David Harry;
Yost, Kathleen; Wade,
Katrina; Lewin, Sharyn;
Burke, James; Rose, Peter;
Werner, Theresa; Bergman,
Melanie; Van Le, Linda;
Slomovitz, Brian; Brown,
Amy; Press, Josh; Braly,
Patricia; Keck, Sara; Colon-
Otero, Gerardo; Lee, Arielle;
Sharma, Sudarsham;
Cloven, Noelle; Bailey,
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