A Clinical Study to See the Effect of Homoeopathic Medicines in Polycystic Ovarian Syndrome of Reproductive Age Group between 12-45 Years
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International Journal of Health Sciences and Research
Vol.10; Issue: 3; March 2020
Website: www.ijhsr.org
Original Research Article ISSN: 2249-9571
A Clinical Study to See the Effect of Homoeopathic
Medicines in Polycystic Ovarian Syndrome of
Reproductive Age Group between 12-45 Years
Priti Ashok.Malvekar1, Sameer S.Nadgauda2, Arun Bhargav Jadhav3
1
Post Graduate,
2
Assistant Professor, Department of Practice of Medicine, Homoeopathic medical college and Hospital, Dept.
Of Postgraduate and Research Centre, Pune-Bangalore Highway, Katraj Dhankawadi, India.
3
Principal, Homoeopathic Medical College and Hospital, Dept. Of Postgraduate and research Centre, Pune-
Bangalore Highway, Katraj-Dhankawadi, India.
Corresponding Author: Sameer S.Nadgauda
ABSTRACT
Objective of the study -The present study was single arm, clinical study to determine the role of
homoeopathic medicines in regulation of menstrual cycle.30 patient fulfilling the eligibility criteria
enrolled in this study was underwent homoeopathic intervention, clinical evaluation and detailed
menstrual history at baseline.
Results- Out of 30 cases, 14 cases (46.66%) showed good improvement in cases of irregular menses,
21 cases (63.3 3%) showed good improvement in Complaints of acne and 25 cases(83.33%) showed
good improvement in cases of health related quality of life related to PCOS.
Conclusion-The Homoeopathic medicines showed significant improvement treating PCOS. From the
analysis of the above results obtained it is obvious that Homoeopathic treatment is effective in
Polycystic Ovarian Syndrome. Cases can be treated successfully by homoeopathic treatment. We
should consider mental general and constitution of patient for most similar homoeopathic remedy.
Life style modification along with homoeopathic treatment is effective in reducing signs and
symptoms of PCOS.
Keywords- Homoeopathy, Polycystic Ovaries, Menstrual Irregularity, Polycystic Ovarian Syndrome
Questionnaire.
INTRODUCTION ordinarily have many number of little cysts
Polycystic Ovarian Syndrome around the edge of their ovaries. Polycystic
otherwise called PCOS OR PCOD ovaries mean the ovaries containing
[Polycystic Ovarian Disorder] is a typical countless blisters that are not greater than
hormonal issue and a main source of female 8mm and grow a larger number of follicles
infertility around the world. PCOS is consistently than ordinary ovaries. The
additionally called as Stein-Leventhal growths are the egg containing follicles that
Syndrome after two specialists who don't grow appropriately as a result of
originally depicted it in 1935 [1] The hormone imbalance. A few females proceed
Rotterdam 2003 criteria characterizes PCOS to create PCOS [Polycystic Ovarian
as frequency of any two of 3 key criteria in Syndrome] which implies they have
particular, oligoovulation and anovulation, different indications including polycystic
hyperandrogenism and polycystic ovaries ovaries. PCOS might be heredity also.
[PCO]. [2][3] Poly cystic Ovarian Syndrome Studies shows that ladies with family
(PCOS) is a condition wherein females ancestry of polycystic ovaries are half
International Journal of Health Sciences and Research (www.ijhsr.org) 43
Vol.10; Issue: 3; March 2020Priti Ashok. Malvekar et.al. A clinical study to see the effect of homoeopathic medicines in polycystic ovarian
syndrome of reproductive age group between 12-45 years
bound to create PCOS.PCOS is seen as the Homeopathy directs the menses in
most widely recognized explanation behind characteristic manner. Diminishes Hirsutism
menstrual abnormalities in 4-12% of ladies (undesirable hairs) and builds the odds of
of conceptive age [12-45 yrs. old]. [4][5] 5- considering. PCOS is the most widely
10% of ladies create PCOS during their recognized reason for anovulatory
young or youngster bearing years. [6] infertility. There is absence of awareness in
Worldwide PCOS influences up to 6-7% of the public about PCOS and its difficulties
the populace. In any case, the pervasiveness like fruitlessness, diabetes type 2,
explicit to the nation fluctuates widely. In cardiovascular sicknesses. Passionate
India, the frequency of PCOS/PCOD is on prosperity issues are critical. [9,10] In
the climb; about 35% of ladies experience Allopathy the medications ordinarily
the ill effects of it. In 2014 examination led utilized for treatment in ladies with PCOS
in Mumbai (independent) among 600 pre- are metformin which can bring down TSH
adult young ladies detailed an expected levels and hypothyroidism.
commonness of 22.5% when the finding There are scarcely any reports
was finished utilizing Rotterdam criteria. showing the convenience of the
Another examination was led by All India Homeopathic treatment. Symptomatic just
Institutions of Medical Science(AIIMS) it as ultrasonological improvement in PCOS.
was discovered that one out of four females Yet, more investigations are required with
experience the ill effects of PCOS. appropriate thoroughness.
The Respondent population right
now to the conceptive age bunch 12-48 MATERIAL AND METHODS
years. Most noteworthy number of sufferers Study setting – A clinical study was carried
was the understudy classification with out on with detail case study and follow up
21.27% of them experiencing the Disorder. in Bharati Vidyapeeth Medical Foundation’s
This demonstrates more young ladies Homoeopathic Hospital, OPD, IPD and with
increasingly inclined to hormonal the help of senior Homoeopathic physicians.
imbalance. [7] PCOS Present with different Total 30 patients of Reproductive age group
level of Symptoms like sporadic, rare between 12-45 yrs. who were suffering from
periods inside 3 or 4years of beginning polycystic ovarian syndrome. (PCOS) was
discharge lighter overwhelming during enrolled for the study which fulfils the case
period, weight gain, and unnecessary hair definition & inclusion /exclusion criteria
growth to changing degrees on face, chest, those who were participated willingly in
and lower midriff. Moderate stomach research. Since it is a time bound study,
inconvenience during periods, skin subject attending, Bharati Vidyapeeth
inflammation, and over the top skin Medical Foundation Homoeopathic
development on neck or in armpit Hospital, peripheral O.P.D. and various
additionally called as acanthosis nigricans. rural and urban camps series.
Bone pain [arthralgia] and male pattern Study design – A prospective clinical trial
baldness [alopecia], stoppage, flauntulence, interventional single arm single blind
and heartburn. Polycystic ovarian disorder method. Study was carried out at Bharati
(PCOS) Divided essentially into two types. Vidyapeeth Medical Foundation
[8]
1. Insulin Resistant (IR) PCOS. 2. Non- Homoeopathic Hospital, peripheral OPD,
Insulin Resistant PCOS. Various rural & urban camp series, OPD,
The main cause of PCOS lies in the IPD from 20192020 (Approximately 25
hormonal aggravation. Homeopathy weeks).minimum 30 Cases was selected
redresses the hormonal aggravation and which fulfils the case definition & inclusion
brings harmony, without the danger of and exclusion criteria those who
reaction. It is anyway basic to take participated willingly in the research. Data
homeopathic treatment for PCOS. collection was done through Rotterdam
International Journal of Health Sciences and Research (www.ijhsr.org) 44
Vol.10; Issue: 3; March 2020Priti Ashok. Malvekar et.al. A clinical study to see the effect of homoeopathic medicines in polycystic ovarian
syndrome of reproductive age group between 12-45 years
2003 criteria as per ASRM (American remedy is already available in the
society of reproductive medicine) & Homoeopathic literature, well proved on
ESHRE (European society of human healthy human beings and is harmless,
reproduction and embryology) guidelines. having no side effects.
Intervention Inclusion criteria- inclusion criteria for the
Patients fulfilling the eligibility criteria was study are: 1) Female aged 12-45years. 2)
enrolled to receive the homoeopathic Oligomenorrhoea (intermenstrual period of
intervention. Medicine was given in 30C, more than 35 days for 3 consecutive cycles/
200C or 1M, LM potency as per the amenorrhea for more than 3 months (2 years
prescribing totality. The medicines were after menarche) 3) 3) ultrasound findings of
repeated depending on the potency and polycystic ovaries. [11] 4) Clinical evidence
complaints of the patient in accordance with of hirsutism (Ferriman score 8 and above)
[12]
the principles of homoeopathy. and/ or acne (acne global severity scale
score 1 and above) [13] 5) Body Mass Index
Selection of tool – (BMI) 23 and above. 6) Females who are
Drug was acquired from standard pharmacy diagnosed with PCOS. 7) Patient who
(SBL Uttarakhand) & was stored as per willing to give written informed consents
rules of Homeopathic Pharmacopoeia. for research participation.
Medicines was stored in Bharati Vidyapeeth
Homoeopathic Pharmacy, Katraj, Pune- Exclusion criteria – 1) Patient with other
411043.Liquid was stored in amber colour systemic illnesses (DM, Cushing syndrome,
glass bottle kept in dark place, under hyperprolactenemia. 2) untreated hypo or
appropriate temperature, away from hyperthyroidism. 3) Adrenal hyperplasia
sunlight& humidity condition. Freshly and adrenal tumour4) ovarian tumour. 5)
prepared powder dose was used for Hyperthecosis. 6) History of intake of drugs
dispensing purpose. Log no. & Batch no. aldactone/ metformin or history of oral
was maintained. contraceptive pills (OCP) use or intake of
drugs known to interfere with carbohydrate
Brief of procedures- metabolism 4 weeks prior to enrolment. 7)
Selection of remedy- The remedy was Pregnancy, breast feeding. 8) Cases with
selected after case taking and making the any systemic disease.
totality of the symptoms on the basis of Statistical Analysis –Descriptive statistical
constitution & given in powder (Lactose) & analysis of the scores in terms of mean,
globule (Sucrose) & liquid form. median, standard deviation and pre and post
Dose and Strength of the Drug- Medicine analysis (paired t test ) was performed using
was given in 30C, 200C, LM / 1M potency GRAPH PAD PRISM version .8.0 for
as per the prescribing totality. The medicine different parameters. The results obtained
was repeated depending on the potency and are presented and discussed in the
requirement of the patient complaints in subsequent section.
accordance with the principles of
homoeopathic posology. RESULTS
Drug dispensing- Was done in globule A total number of thirty cases were included
(sucrose) & powder(lactose) and liquid in the study after screening the case as per
form. (Ref. Aph. No.272 ). the inclusion criteria. All the thirty cases
were followed up for a minimum period of
Declaration – Was given that the drug used 25 weeks. These cases were subjected to
here is not harmful to human beings. Said statistical study.
International Journal of Health Sciences and Research (www.ijhsr.org) 45
Vol.10; Issue: 3; March 2020Priti Ashok. Malvekar et.al. A clinical study to see the effect of homoeopathic medicines in polycystic ovarian
syndrome of reproductive age group between 12-45 years
Table-1 Paired differences of menses interval before and after treatment
N MEAN MEDIAN SD SEM DF T VALUE P VALUE
INTERVAL OF MESNSE
BEFORE
TREATMNT 30 45.70 45.00 7.557 1.380 7.778 29Priti Ashok. Malvekar et.al. A clinical study to see the effect of homoeopathic medicines in polycystic ovarian
syndrome of reproductive age group between 12-45 years
CONCLUSION 5. Farah L, Lazeby AJ, Boots LR, Azziz R.
Constitutional treatment along with Prevalence of Polycystic Ovarian Syndrome
anti-miasmatic remedy seems to be in women seeking treatment from
efficacious. The Homoeopathic medicines community electrologists. Albama
showed significant improvement treating Professional Electrology Association Study
Group .J Report Med 1999; 44:870-874
PCOS. From the analysis of the above 6. Heidi A. Polycystic ovary
results obtained it is obvious that syndrome (PCOS) in urban Indi
Homoeopathic treatment is effective in Man love University of Nevada Las
Polycystic Ovarian Syndrome. Cases can be Vegas..
treated successfully by homoeopathic 7. International journal of innovative research
treatment. We should consider mental in science entering & technology Vole 6
general and constitution of patient for most issue 7th July 2017.
similar homoeopathic remedy. Life style 8. Rotterdam ESHRE/ ASRM sponsored
modification along with homoeopathic PCOS consequences workshop group.
treatment is effective in reducing signs and Revised 2003 consequences diagnostic
symptoms of PCOS criteria and long term health risk related
PCOS. Human report 2004.
9. Assessment & management of PCOS
AKNOWLEGMENT
summary of an evidence based guideline.
I would like to thank my PG Guide Dr. Sameer
www.mja.com.all published 2011-9-19.
S. Nadgauda, Principle Dr. Arun B. Jadhav. I
10. Lamba CD, Oberai P, Manchanda RK, Rath
also would like to thank Dr. Mrunal A. Nerlekar
P, Bindu PH, Padmanabhan M. Evaluation
and Dr. Anita V. Patil for permitting and
of homoeopathic treatment in polycystic
providing facilities to carry out present study. I
ovary syndrome: A single-blind,
would like to thank all the participants for their
randomised, placebo-controlled pilot study.
cooperation and support. I would also like to
Indian Journal of Research in
thank Dr. Sheetal Kadam for her support and
Homoeopathy. 2018 Jan 1;12(1):35.
cooperation in present study.
11. Alliance PA. Evidence-based guideline for
the assessment and management of
REFERENCES
polycystic ovary syndrome. Jean Hailes
1. Stein IF, Leventhal ML. Amenorrhea
Foundation; 2011.
associated with bilateral polycystic ovaries.
12. ANDRADE VH, MATA A, Borges RS,
AMJ Obstet Gynecol. 1935; 29:181-191.
Costa-Silva DR, Martins LM, FERREIRA
2. Azziz R, woods ks, Reyna R, key TJ,
PM, Cunha-Nunes LC, SILVA BB. Current
Knochenhauer E S, Yildiz B O. The
aspects of polycystic ovary syndrome: A
prevalence and features of the polycystic
literature review. Revista da Associação
ovary syndrome in an unselected population
Medica Brasileira. 2016 Dec;62(9):867-71.
J. Clin. Endocrinal, Metab 2004;89(6).2745-
13. Cronin L, Guyatt G, Griffith L, Wong E,
2749.
Azziz R, Futterweit W, Cook D, Dunaif A.
3. Rotterdam ESHRE/ASRM- Sponsored
Development of a health-related quality-of-
PCOS Consensus Workshop Group.
life questionnaire (PCOSQ) for women with
Revised 2003 consensus on diagnostic
polycystic ovary syndrome (PCOS). The
criteria and long term health risks related to
Journal of Clinical Endocrinology &
polycystic ovary syndrome. Fertil,Steril.
Metabolism. 1998 Jun 1;83(6):1976-87.
2004;81:19-25.
4. Knochenhauer ES, Key TJ, Kaiser- Miller
M, Waggoner W, Boots LR, Aziz R. How to cite this article: Malvekar PA, Nadgauda
Prevalence of Polycystic Ovarian Syndrome SS, Jadhav AB. A clinical study to see the effect
in unselected black and white women of the of homoeopathic medicines in polycystic
South-eastern United States: a prospective ovarian syndrome of reproductive age group
study. J Clin EndocrinolMetab 1998;83: between 12-45 years. Int J Health Sci Res. 2020;
3078-3082. 10(3):43-47.
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International Journal of Health Sciences and Research (www.ijhsr.org) 47
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