5 7 APRIL 2021 - POSTER PRESENTATIONS "Committed to Complete Solutions in Pharmaceuticals"
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5 - 7 APRIL 2021
Dubai World Trade Centre, United Arab Emirates
“Committed to Complete Solutions in Pharmaceuticals”
POSTER PRESENTATIONS
Organized by
duphat.ae
His Highness Sheikh Khalifa bin Zayed Al Nahyan
President of the United Arab Emirates
His Highness Sheikh Mohammed bin Rashid Al Maktoum Vice President and Prime Minister of the United Arab Emirates and Ruler of Dubai
TABLE OF CONTENTS 5 About Dubai 7 Message from the Chairman 8 Message from the Executive Chairman 9 General Information 10 Scientific Committee 12 Professional Posters 32 Students Posters
Discover
Dubai
Dubai’s economy has changed and grown across
several sectors as it has transformed into a
diversified, innovative service-based economy
supported by the emirate’s government that aims
to improve the business environment, commercial
transparency and accelerate productivity growth,
which helps in return in gaining the investors and
entrepreneurs’ trust.
In the last few years, the Emirate excelled as a
unique destination for meetings, conferences,
and exhibitions as it hosts world-class events
for professionals in almost every industry all
across the world, whether it be sport, economic,
humanitarian, entertainment, lifestyle or art
and culture which play an important role in the
business success.
5 DUPHAT 2021
Dubai, a Global Metropolis
Besides being one of the most vibrant, lavish, and cosmopolitan cities in
the world, Dubai has flourished as a dynamic international city and a regional
hub for business and investments, thanks to its strategic location between
the East and the West and the prospective vision of its leaders.
Dubai is also the city where business meets busiest airport for international travel – Dubai
leisure with abundance of activities to do ranging International Airport.
from shopping in the world biggest mall to more
Dubai is an unmatched city with great
adventurous activities like the adrenaline-
opportunities; a place to share aspirations,
pumping safaris, and with its extensive road and
experiences and inspiration and a global platform
transport system, getting around the city cannot
for knowledge-based, sustainable, innovation-
be easier.
focused businesses. Dubai is certainly a great
This metropolis does not stop growing as it keeps example on how a city plans ahead and works on
breaking records on many scales such as the tallest its robust progress in many fields.
man-made structure in the world - Burj Khalifa,
With state-of-the-art infrastructure and modern
the world’s largest shopping center – Dubai Mall,
venues, Dubai has become today the go-to place
the world’s tallest performing fountain – Dubai
when it comes to business and the most sought-
Fountain, the world›s largest picture frame –
after destination for tourism in the Middle East
Dubai Frame, one of the world’s most iconic hotels
and Africa region.
-Burj Al Arab, a set of floating islands in the shape
of a world map – the World Islands, and the world’s
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Message from the Chairman
Dr. Ali Al Sayed Hussain
Chairman, DUPHAT
The profession of Pharmacy has faced its greatest challenges in recent history with a pandemic that
was most overwhelming. The remarkable element in this scenario is that Pharmacy kept pace with the
times and evolved dramatically battling the virus at various levels. As frontline healthcare professionals,
Pharmacists all around the world, continue to provide direct patient care, adopting innovative strategies
to minimize the adverse impact of Covid-19. The scientists and the pharma industry have phenomenally
worked day and night to provide solutions by discovering, repurposing and inventing agents that
are proving highly efficacious as treatment options as well as preventative vaccines. The pandemic
undoubtedly has been a tremendous challenge, but it definitely revolutionized pharmacy practice in
many positive ways. The improved collaboration with other healthcare professionals and the wider role
in primary care has helped highlight the pharmacists as one of the most trusted professionals worldwide
alongside other healthcare professionals.
Continuing professional development is a vital determinant of a progressive approach to specializing
and upgrading the profession. DUPHAT conferences have over the years proved significant in this effort.
It has been a year since we had our 25th Anniversary edition in 2020. The world has changed and as
they state a new normal has arrived. In this context, DUPHAT has re-engineered itself to ensure that the
essence of DUPHAT conferences is retained and new paradigm is implemented with greater innovation.
DUPHAT 2021 is a hybrid event with both face-to-face as well as online presentations adding greater
value and experience for all those participating physically as well as remotely.
From its nascent beginnings in 1995, DUPHAT has become an internationally recognized pharmaceutical
conference. Professionals, academicians and experts have contributed significantly to DUPHAT’s stature
and presence in the global scenario. International organizations ASHP, EUFEPS, SHPA, ISPE, ESOP,
IATDMCT, ACPE among others have been patronizing the conference all these years to ensure greater
collaboration and cooperation. The constant support of Dubai Health Authority has helped DUPHAT
emerge as the premier conference in the region.
DUPHAT 2021 shall feature speakers from USA, Canada, Europe and the Middle East. They shall present
their latest perspectives on pharmaceutical science in the intensive 3–day hybrid program with a wide
variety of topics emphasizing Covid-19 apart from topics in pharmacy practice, Health Technology
Assessment (HTA), pharmacoeconomics, pharmaceutical science, leadership, impact of new durgs,
automation, empowerment of pharmacists and best practices. DUPHAT 2021 also features Managerial
skills workshop, parallel scientific presentations from the region, professional faculty and student poster
sessions.
As in the past, DUPHAT envisions to be a ‘meeting of the minds’ avenue for pharmacists, industry
professionals, marketing professionals, academicians, researchers, scientists, students and other
associated healthcare professionals.
Looking forward for your presence at DUPHAT 2021.
duphat.ae 7
Message from the Executive Chairman
Dr. Abdul Salam Al Madani
Executive Chairman, DUPHAT
It gives me great pleasure to welcome you all to the 26th edition of the Dubai International Pharmaceuticals
& Technologies Conference and Exhibition – DUPHAT, the event that the UAE is proudly organizing
despite the current challenges, thanks to the UAE leadership.
Since the spread of the COVID-19 pandemic, the world has been fighting an invisible enemy that
has affected all aspects of our lives and the pharma industry is not a far from that, therefore, holding
conferences such as DUPHAT is crucial at this time as we need deeper look into the facia of the industry
to discuss the latest rules and regulations governing drug manufacturing, drug research and the impact
of technology on the pharmaceutical industry in times like these.
In this edition, DUPHAT unique agenda will feature 3 conference tracks running in parallel gathering
roof top-notch researchers, key decision makers, drug experts and industry partners under one roof to
discuss top pressing changes in the pharma industry and tackle various topics related to this significant
field. The conference will be available virtually as well to make sure that everyone will get the knowledge
they need during such times.
Running parallel to the conference, the DUPHAT exhibition and DUPHAT -TECH provides the leading
exhibitors in the pharma industry from the region and the world a unique opportunity to showcase
their latest products while also offering them a platform to interact, engage and collaborate with the
biggest brands in the local pharmaceutical industry to expand their footprint in the region.
On this occasion, I would like to thank our partners, supporters, renowned speakers, experts, educators,
exhibitors and all key stakeholders whose continuous efforts have enabled us to make DUPHAT the most
successful pharma event in the region over the last so many years.
I would like also to call upon you all to adhere to all safety measures imposed by the authorities in order
to maintain the safety and health of all.
I wish you all a fruitful conference and I hope you enjoy your stay in Dubai.
8 DUPHAT 2021
General Information
Opening Ceremony Free Car Park
Date: 5th of April 2021 Car parking space for exhibitors and visitors is located
Time: 10:00 am opposite Convention Gate across Al Mustaqbal Street.
Location: Hall 7 Paid Car Park
Multi-storey Car park - Level 3, 4, and 5.
Event Dates
5 - 7 April 2021 Taxis
Taxis are plentiful and reasonably priced. Taxis are
available in front of IBIS Hotel and Novotel Hotel.
Venue
Dubai International Convention & Exhibition Centre
Sheikh Maktoum Hall & Halls 4 - 8, Pavillion Dubai Metro
The Dubai Metro station is located near the exhibition
gates outside Sheikh Saeed Halls.
Exhibition Opening Hours
Monday 5th of April 10:00 – 17:00
Telephones
Tuesday 6 of April
th
10:00 – 17:00
Public telephones are available in the lobby of the
Wednesday 7th of April 10:00 – 14:00 exhibition halls.
Conference Timings Prayer Room
Monday 5th of April 10:00 – 17:00 The Gents prayer room is located at the second floor
Tuesday 6 of April
th
10:00 – 17:00 opposite Hall 6. The Ladies prayer room is located at
the second floor opposite Hall 7.
Wednesday 7th of April 10:00 – 16:00
Conference Hall Media Centre
INDEX Media' media centre is located outside Hall 6
Sheikh Maktoum Hall
Exhibition Halls Lost and Found
For lost and found item/s please ask the assistance of
Halls 4 -8
the security staff or the organizers.
Admission
For trade visitors and delegates only, registration form
First Aid
First Aid Centre is located adjacent to Hall 5. For
must be filled up prior to entry. Children below the age
assistance please contact any of the security staff or
of 15 will not be admitted.
the organizers.
Business Center
Business Center is located in the Concourse near Hall 1.
Restrooms
Restrooms are located in the foyers and inside
exhibition halls.
Organizer Offices
INDEX Conferences & Exhibitions Organisation Est.
The Organiser’s Office is located outside Hall 8. It
DWTC Exhibitor Services
DWTC Exhibitor Services is located in Concourse 1
is fully operational throughout the exhibition timing
near Hall 2.
including build up & tear down.
Dining and Retail Disclaimer
The organizer and publisher of the official catalogue will
A wide range of outlets are located in the concourses
not be held responsible for the statement made in this
1 and 2. Services include coffee shops and restaurants,
catalogue on behalf of the exhibitors, nor for any errors
business centre, courier service, banks, pharmacy, post
or ommissions that may have occured, although utmost
office and telecom outlet. Few restaurants available
care has been taken to ensure that the information is
outside Exhibition Gate – Plaza Area.
accurate in this catalogue.
Color Scheme for Name Tags
VIP Chairperson Speaker Exhibitor
Contractor Committee Organiser Press
Trade Visitor Managerial Workshop Buyer Delegate
E - Delegate
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Scientific Organizing Committee
Dr. Ali Al Sayed Hussain Mohammed Arfan Asif Nada Ali Essa Amiri
Chairman
Mai Mahfouz Mohammad Al Issa Edwin Rajakumar Muna Saeed Abdulla Mohamed
Assem ElGarhy Hind Juma Al Falasi Taha AbdelAzim Mady Hamad
Maryam Farid Ibrahim Mohammad Ishtiyaq Qureshi Khawla Ibrahim Hassan
Habib Al Redha
Hanan Hussain Nasser Ali Ahmed Ali Mohamed Ibrahim Sara Mohamed Esam
Saeed Nader Abel Aziz Nawar
10 DUPHAT 2021Scientific Committee
Mohamed Sameh Ali Mohamed Lina AbdulRahman Bahjat Mortadi Mohamed Ramadan Marzouk
Moustafa
Ahmad Mohammed Jafar Mehrabi Mahat Hussein Nsaif
duphat.ae 11PROFESSIONAL POSTERS
Poster ID: 43
Main Author: Mrs. Aisha Salam
Co-Authors: Dr. Mosab Arafat
Institution: Al Ain University of Science and Technology, Abudhabi, Timor Leste
DEVELOPMENT AND IN VITRO EVALUATION OF POLOXAMER-188 MATRIX
SYSTEMS USING DILTIAZEM HCL
The objective of this study was to develop an oral controlled release of Diltiazem HCl, and compare it with the reference
drug Tildiem® with the use of hydrophilic matrix system that contains poloxamer-188 together with hydroxypropyl
methylcellulose and strealy alcohol. Besides, various formulations containing 3.5:3.5:1, 2.5:4.5:1, 3:4:1, 4:2.5:1.5, 4.5:2.5:1
and 3:3.5:1.5 of poloxamer-188, HPMC and stearyl alcohol respectively, were developed. However, a number of assessments
were carried on to develop the formulation and determine the significance of poloxamer-188. The influence of poloxamer-188
on the release profile of the formulation from the matrix system was determined as poloxamer-188 increases the viscosity
of the gel layer, resulting in a reduction of the dissolution medium to penetrate into the gel network. For that reason, the rate
of dissolution of the matrix tablet is decreased, delaying the release of Diltiazem HCl. Hence, the drug release mechanism is
controlled by the diffusion of drug through the gel layer and matrix erosion as poloxamer-188 increases drug solubility and
wettability. Our findings revealed that FD3 formulation containing 3:4:1 ratio of poloxamer-188, HPMC & stearly alcohol
achieved the best controlled release profile. Comparatively to the reference drug, FD3 T50% was 120 min while the reference
drug T50% was 30 min. These outcomes indicate that the combination of Poloxamer-188 together with HPMC and stearyl
alcohol play a significant role in controlling and modifying drug release from the hydrophilic matrix system.
Keywords: Poloxamer 188, Diltiazem HCl, HPMC, reference drug, hydrophilic matrix, controlled release.
Submission ID : 57
Main Author: Shoug Majed Binobydaan
Co-Authors: Wafa Al-Sultan, Mzoon Albedaiwi, Seba Alonizi, Nouf Abutheraa
Institution: Princess Noura University, Security Forces Hospital
KNOWLEDGE AND REPORTED SIDE EFFECT OF WOMEN CONTRACEPTIVES
USE IN THE KINGDOM OF SAUDI ARABIA
Introduction: Contraceptives are an integral part of modern life; it has a clear beneficial effect on women's health. Nonetheless,
it has been associated with an increased risk of cardiovascular disease. There is poor knowledge of contraceptives and its
various types among the population in Saudi Arabia
Objective: To assess knowledge of contraceptive Saudi women`s, use and evaluation of all reported side effects. Methods:
A cross-sectional study conducted among Saudi women. Developed questioner was disrupted to Saudi women's in the
waiting area of the ob-gyn clinic of Security Forces Hospital and trend media.
Results: A total of 1920 participants took part in this survey. We excluded two who answered after the closing day of
the survey, excluded male participants (n=124), women who are older than 50 years old (n=61) and younger than 18
years old (n=18). Finally, we excluded women who refused to participate in this study (n=95). The average age of women
participated in the study was 33years old. From the total of 1058 women who are using contraceptives, there were 78.8%
used pills, 11.7% used intrauterine device, 4.1% used condom, 2.7% transdermal patch, leaving the less reported types of
contraceptives to be injection, tube implant and vaginal ring to represent 1.4%, 1% and 0.2% respectively. From the same
1058 women, the most common reported side effects are psychological effect and weight gain in 340 and 256 women
respectively. Upon investigation, based on the participants the common preferable contraceptive was oral contraceptive in
373 women. Followed by an intrauterine device in 172 women, followed by condoms in 91 women.
Conclusions: Future public campaigns are needed to enhance social knowledge and help them achieved fewer side effects
and better use of contraceptives.
duphat.ae 13Poster ID: 98
Main Author: Saeed Muhammed Umer jawed
Co-Authors: Majid Jaweed , Hamdan Almalki, Khadija Sekhairi, Mohammed Aljefry
Institution: Security Force Hospital Makkah, MAkkah, Saudi Arabia
IMPLEMENTATION OF STANDARDIZED DRUG IN HEALTH INFORMATION
SYSTEM (HIS) AND IMPACT ON MEDICATION ERROR
Background: Prescribing error – especially common among residents or specialists – may lead to significant harm if the
error reaches the patient. During the prescribing process, the physician may not check the appropriateness of the dose or
modify the dose according to patient need and upon prescription review by pharmacy most of the errors are discovered and
stopped from reaching the patient. Review of available data from previous incidents show that most prescribing errors occur
mainly with wrong dose and frequency. The annual medication errors report for 2019 showed the highest rate in prescribing
errors with wrong dose and frequency as shown in Pareto chart as this error may lead to harm if reached the patient.
Objective
To decrease medication errors.
Minimize the need for order transcribing.
Minimize the need for dose calculation.
Method : With Help of the Pareto chart, tackling 80% of the problem leads to prescribing error to prevent recurrence, as the
main method to add standard dose & frequency for the medications in the health information system and upon selecting the
drug name dose and Frequency will be automatically updated for patients with normal hepatic and renal function which do
not require typing or selection by physician unless does need modification for a special population group.
Result : 228 of 1122 medications added with standard dose and frequency in the health information system and The results
show a great reduction in medication error related to prescribing of wrong dose by 31% or frequency by 41% and Overall
35% reduction in Prescribing error as result of drug standardization in the health information system where error is reported
mainly for drugs without standard dose in HIS.
Conclusion: Implementation of standardized drug dosage information in the health information system minimizes the need
for multiple Typing and reduces prescribing error.
Poster ID: 110
Main Author: Etedad Nour Alla Elbasier
Co-Authors: Asim Ahmed Elnour, (PhD, MSc), Clinical Pharmacy Program, College of Pharmacy, Al Ain University,
Abu Dhabi-UAE
Institution: College of Pharmacy Gulf Medical University United Arab Emirates, Ajman, United Arab Emirates
SYSTEMATIC REVIEW OF ANTIBIOTICS USED FOR MANAGEMENT OF
COMPLICATED URINARY TRACT BACTERIAL INFECTIONS AND ACUTE
PYELONEPHRITIS
Background: The management of complicated urinary tract infections has been confronted with suboptimal success,
treatment failures, recurrent infection and development of bacterial resistant strains.
Aim of the review: We report the alternative antibiotics with optimum efficacy, improved safety profile and less microbial
resistance.
Method: The current systematic review covers 1976 subjects with complicated urinary tract infections.
Results: The success rate in the microbiologic modified intent-to-treat population was 98.4% with meropenem-vaborbactam
2g/2g versus 94.0% with piperacillin-tazobactam 4.5g/0.5g (difference, 4.4% [95% CI, 0.7% to 9.1%]; P < .001). The
microbiological eradication rates for subjects receiving plazomicin at 10 mg/kg, 15 mg/kg, and levofloxacin 750 mg, were
50.0%, 60.8% and 58.6%, respectively. The combined microbiological and clinical responses were 70% for finafloxacin 800
mg (5-days), 68% for finafloxacin 800 mg (10-days), and 57% for a 10-days ciprofloxacin. The microbiological eradication
success rate was comparable between the oral sitafloxacin 100 mg and ertapenem 1 g, groups (84.2% versus 75%, P=
14 DUPHAT 2021 | PROFESSIONAL POSTERS0.677). The microbiological response rates were 95.5%, 98.6% and 98.7%, respectively, confirming non-inferiority of both
imipenem-cilastatin 500 mg plus relebactam doses (125/250 mg) to imipenem-cilastatin plus placebo. The clinical response
rates were 97.1%, 98.7% and 98.8%, respectively. The Ceftazidime-avibactam 2g/0.5 g versus doripenem 500 mg has
demonstrated microbiological eradication superiority and similar efficacy against ceftazidime-non-susceptible pathogens.
The combined symptomatic resolution/microbiological eradication at test-of-cure: 71.2% versus 64.5% (difference, 6.7%
[95% CI, .30% to 13.12%]).
Submission ID : 112
Main Author: Samar Alshawwa
Institution: Princess Nourah bint Abdulrahman University
ENHANCED ANTIBACTERIAL ACTIVITY OF CIPROFLOXACIN OCULAR INSERTS
AGAINST P. AERUGINOSA AND S. AUREUS
Abstract Background: Ciprofloxacin hydrochloride is one of the most common antibiotics used for treating bacterial infections,
and enhancing its antibacterial activity is considered one of the major concerns of scientific researchers. Objectives: The
objective of this work is to show the enhancement of the antibacterial activity of ciprofloxacin ocular inserts against P.
aeruginosa and S. aureus. Method: In this study the enhancement of antibacterial activity of ciprofloxacin ocular inserts
against P. aeruginosa and S. aureus was tested by using microbiological susceptibility tests. The inserts composed of two
types of spray dried matrices SD1 and SD2 Results: Promising results were obtained and the two formulae were found to
be effective against P. aeruginosa and S. aureus, also the results indicated clear zones of inhibition every day up to seven
days. Conclusion: It is concluded that ciprofloxacin hydrochloride is a good antibacterial agent.
Poster ID: 126
Main Author: Majid Mohammed Umer jaweed
Co-Authors: Saeed Mohammed jaweed, Samar Adil Al-turkistani, Iman Ali Baarmah
Institution: Security Forces Hospital - Makkah, makkah, Saudi Arabia
IMPACT OF INTEGRATION OF QR CODES INTO ERP AND EXPIRY
MANAGEMENT SOFTWARE FOR MEDICATION REQUEST & EXPIRY CHECKING
Background:: At the pharmacy department in SFHM, two tasks take a lot of the staff time to do. First, medications requests
that take around 3 to 4 hours from the technician's time as she has to check and write the medications needed to be requested
on paper before transcribing to ERP system. Also, it has to be done on a specific weekday at morning shift and sometimes the
request gets delayed due to engagement of the technician in medication preparations. Second, expiry checking of medications
where the pharmacy is divided into columns and each pharmacist assigned to a couple to check for expired and near expired
drugs. the pharmacists are overloaded and this process adds a burden to the staff to check as it takes a lot of time in order
to check the drugs, update expiry dates on papers, transcribing it into expiry database which results in delay in finishing and
removing the expired medications from pharmacy plus wasting a lot of pharmacist time.
Objective: Eliminate waste from multiple steps and save time.
Method: Medication request and expiry checking processes were assessed prior to introducing the QR codes and the
estimated time required to complete tasks are compared prior and after QR integration into ERP and expiry management
software.
Result: Integration Implementation of QR code results in 66% (3 to hours) reduction in time required for Medication Request,
49 % (44.2 to 22.5 minutes) reduction minutes required for Expiry checking, moreover Eliminating and combining the steps by
using QR code result in 8.3 Hours elimination of transcribing step.
Conclusion: Using the QR code scanner to perform some tasks around the pharmacy resulted in a significant reduction in time
needed to finish those tasks and allow the staff to perform other tasks that need their attention around the pharmacy.
duphat.ae 15Poster ID: 128
Main Author: Eman M. El-labbad
Co-Authors: Abdelsattar M. Omar , Ahmed M. Al-Abd
Institution: College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates
DESIGN, SYNTHESIS AND MOLECULAR DOCKING STUDIES OF IMIDAZOLE
DERIVATIVES AS NOVEL AUGMENTED PROOXIDANT ANTICANCER AGENTS
Prooxidant augment therapy is a new Reactive Oxygen Species-based anticancer strategy that was recently developed.
In this strategy, a prooxidant compound is combined with an inhibitor of antioxidant enzyme(s). Such combination works
synergistically, causing a significant cellular accumulation of ROS, which cannot be effectively neutralized due to the induced
impairment of the antioxidant system, resulting in rapid cancer cell death. In the current study, we synthesized 15 imidazole
derivatives (4a-o) as new unimolecular augmented imidazole-based prooxidant therapeutic agents. The design strategy of
these compounds was based on incorporating prooxidant side chain R to the core imidazole scaffold of the recently reported
cytotoxic lead compound 2-(5-bromothiophen-2-yl)-4,5-diphenyl-1H-imidazole. In addition to the Michael acceptor α,
β-unsaturated ketones (Scaffold 1) to undergo Michael addition type reaction mainly with cellular antioxidant thiol like
thioredoxin reductases, with very limited or no reactivity towards amino and hydroxyl groups which are found in nucleic acid.
SRB-U cytotoxic assay, determination of cellular ROS, apoptosis assessment using annexin V-FTTC staining coupled with
flow cytometry, and molecular modeling studies were conducted to assess the mechanism of action of prepared compounds.
Compound 4a represent prototype of a new class of unimolecular augmented prooxidant having cytotoxic activity IC50 1.9
µM, low resistant fraction R-values (4.4%) on HepG2 cell line. 4a caused a persistent increase of intracellular ROS level
111.1% after 24 hours vs 54.4 % with doxorubicin. In addition to 2.4 folds increase cell in late apoptosis. This is in addition to
in silico molecular docking support binding of 4a to antioxidant enzyme thioredoxin reductase enzyme.
Poster ID: 137
Main Author: Fatima Alzahra Adam Al Nausri
Institution: Independent, Abudhabi, United Arab Emirates
PGX: ARE WE READY?
The entire human genome has been mapped in 2006, and since then, pharmacogenomics discoveries have been growing
dramatically. The world is moving toward personalizing medicine promptly using pharmacogenomics testing. In 2012, FDA
has released pharmacogenomic biomarker in drug labelling, to avoid the adverse effect of drugs and optimize the adequate
dose to the intended patient. Pharmacogenetics test also helped in Black Box Warnings which are the strictest labelling
requirements that the FDA can mandate for prescription drugs. UAE is a prodigious platform for pharmacogenetics equipped
with an infrastructure that capable of conducting tests, applying personalizing medicine, and sequencing the gene for everyone
that can be registered in the Emirates ID, due to the availability of specialized labs, conflation of nationalities that can serve
as the perfect testbed that comprehends a spectrum of different ethnics , and variety in pharmacists with different specialties
and nevertheless, because there is no impossible in UAE dictionary. Which begs the question, are our pharmacist interested
in this field? Do we have enough knowledge?. This study is focused on pharmacy colleges, senior year pharmacy students
and pharmacist working in UAE considering them the foundation milestone of this major step, to elicit a comprehensive
understanding of their awareness toward this topic.
16 DUPHAT 2021 | PROFESSIONAL POSTERSPoster ID: 154
Main Author: Naglaa Saadeldin Mostafa Amin Ashmawy
Co-Authors: Nagla Saad, Eman M El- Labbad, Alshaimaa M. Hamoda, Sameh S.M. Soliman
Institution: City University College of Ajman, Dubai, United Arab Emirates
UAE NATURAL PLANT: PROMISING SOURCES OF ANTIFUNGALS ISOLATION,
CHARACTERIZATION, IN SILICO SIMULATION OF NOVEL STEROID DERIVATIVE
FROM TEPHROSIA APOLLINEA HAVING ANTI-CANDIDA ACTIVITY AGAINST
THE MULTI-DRUG RESISTANT CANDIDA AURIS
The genus Tephrosia is widely distributed throughout the tropical, subtropical and arid regions. The species in this genus are
known for several biological activities including anti-Candida activity, which is mainly attributed to prenylated flavonoids. This
study was conducted to investigate the phytochemicals and pharmacological activity of Tephrosia apollinea, widely grown in
UAE, and to compare/ correlate the results with previously reported literatures.
The extract of dried grinded leaves T. apollinea was subjected to successive chromatography techniques to identify unique
phytochemicals with special pharmacological activity. A novel non reported steroidal compound (TNS) was isolated. In Silico
target identification of newly reported TNS using rational structural analysing and pharmacophore modelling revealed high
structure similarity with 14-α-demethylase enzyme substates such as lanosterol, eburicol and obtusifoliol. Accordingly, TNS
was expected to have antifungal activity since 14-α-demethylase enzyme is well established target of the azole antifungals.
These finding was supported by homology model and molecular modelling docking study of TNS versus C. auris 14-α-
demethylase that revealed unique binding pattern of TNS with substrate binding site. In vitro antifungal activity of TNS was
conducted. TNS exhibited significant anti-Candida activity against the multi-drug resistant Candida auris at MIC50 200
µg∕mL when compared to fluconazole, as positive control.
In conclusion, in the current study we reported a novel steroid derivative, TNS, identified from the plant leaves extract and with
more superior anti-Candida activity than fluconazole. TNS might be new lead compound for new class of 14-α-demethylase
substate like inhibitors.
Poster ID: 155
Main Author: Fithawit Bahran Gebreigziabher
Co-Authors: Rizah Anwar Assadi, Jumana Al-Salloum
Institution: College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates
EVALUATION OF PHARMACIST-LED OUTPATIENT ANTICOAGULATION MTM
SERVICES - SYSTEMATIC REVIEW
BACKGROUND: Various studies have evaluated the effectiveness of different pharmacist-led anticoagulation MTM models
against the traditional routes of physician-led primary care and found consistency in the success of these services. The
rationale of this study is to evaluate various models of pharmacist-led outpatient anticoagulation MTM services established;
for their outcome effectiveness, the limitations and challenges faced to achieve these outcomes and identify areas of further
research.
METHODS: All three reviewers independently searched for articles published in PubMed, Google Scholar and pharmacy
based journals. Reference lists were also used to yield results. RCTs and observational studies that focused on pharmacist-led
anticoagulation service models after the year 2010 were included and their outcomes were evaluated and extracted by two
reviewers. To evaluate the quality of the articles selected CONSORT tool was used to assess RCTs and GRACE tool to assess
observational studies. Data evaluation focused on the design and implementation of the models and their patient related
outcomes with the analysed anticoagulant agent.
RESULTS: In this review 15 articles were reviewed out of which 4 were RCTs and 11 were observational studies. Overall
four commonly utilized pharmacist-led clinic models were identified. The types of services provided by pharmacists ranged
throughout these models, from conducting patient education sessions at different intervals to POCT and alteration of
anticoagulant agents and dosing per patient requirements. Anticoagulation clinics that used telehealth, community pharmacy
duphat.ae 17and self-management models reported better patient outcomes. This was mainly attributed to delivery of patient education and
adequate consultations as patients are better informed within these pharmacist-led clinics. Multiple studies in collaborative
clinics have shown no difference in efficacy outcomes between pharmacist-led and primary care provider models. All models
reported a common challenge in recruitment of treatment-naive patients. In collaborative care models, it is expected that the
cost of POCT might pose a challenge in delivering long term care to patients.
CONCLUSION: Various models of pharmacist-led anticoagulation clinics exist and new models continue to be developed.
Research needs to be continued and evaluated to highlight the pharmacist roles in these clinics and identify the best model
to deliver standardized patient care.
Poster ID: 159
Main Author: Ahmed Thabet Negmeldin
Co-Author: Eman Ellabad
Institution: Gulf Medical University, Ajman, United Arab Emirates
COMPUTER-AIDED DESIGN OF NOVEL SERIES OF PYRAZOLO PYRIMIDINE
DERIVATIVES BEARING SULFONAMIDE MOIETY AS EGFR TYROSINE KINASE
INHIBITORS
Cancer is one of the leading causes of death in the world. In cancer cells, several targets are implicated cancer. Epidermal
growth factor receptor (EGFR) tyrosine kinases family are considered one of the promising targets due to their involvement
in cancer development, growth, and metastasis. EGFR family involves four transmembrane tyrosine kinases including EGFR
or Her1. EGFR was found to be overexpressed in different types of cancers such as lung, breast, and colorectal cancers.
There are currently several FDA-approved EGFR inhibitors for the treatment of various types of cancers, such as erlotinib,
gefitinib, and the recently approved drug neratinib. The present study aims to integrate rational drug design techniques with
Computer-aided drug design simulation to design a series of pyrazole pyrimidine derivatives bearing a sulfonamide group as
novel EGFR inhibitors. Pyrazolopyrimidine nucleus as a bioisostere to the benzopyridine and benzopyrimidine cores found in
the FDA approved drugs was utilized to design the novel EGFR inhibitors. Different virtual computational techniques using
discovery studio 2.5 were conducted to prioritize and filter designed compounds including Force Field Energy calculation of
designed compounds, conformational analysis, molecular docking study of designed compounds to predicted their binding
inside the active site of EGFR. A set of novel compounds having proper in silico binding energy and binding mode with EGFR
are reported as potential anticancer compounds. Synthesis and pharmacological evaluation of the set candidates will be
conducted in future studies.
Poster ID: 163
Main Author: Reham Khaled Abu Hijjleh
Co-Authors: Reham K. Abuhijjleh, Dalia Y. Al Saeedy, Sameh S. Elhady, Ahmed M Al-Abd
Institution: Gulf Medical University, Ajman, United Arab Emirates
ANTI-CANCER ACTIVITY OF THE MARINE METABOLITE TERREIN USING
THREE-DIMENSIONAL CELL CULTURE MODEL UNDER NORMOXIC AND
HYPOXIC CONDITIONS
Terrein is a bioactive marine metabolite isolated from the marine-derived fungal strain of Penicillium species SF-7181, as
well as Aspergillus terreus. Studies showed that terrein exhibits anti-inflammatory activity that is mediated by inactivation
of the nuclear factor kappa B (NF-kB) pathway. This occurs as a result of various mechanisms, most notably the inhibition of
p60/p50 heterodimer translocation into the nucleus, the DNA binding activity of the p65 subunit, and angiogenin production
inhibition. The NF-kB pathway is implicated in various types of cancer due to its anti-apoptotic effects; however, the exact
role of terrein as an antitumor agent remains unclear. Herein, the potential antitumor activity of terrein is evaluated against
different colorectal cancer cell lines (SW-620 and HT-29), under hypoxic and normoxic conditions, using the conventional
monolayer and the three-dimensional in-vitro cell culture model systems. Gemcitabine was used as the reference control to
18 DUPHAT 2021 | PROFESSIONAL POSTERScompare and validate the antitumor activity of terrein. Colorectal cancer cells were grown as multicellular spheroids using
the U-shape-bottom super-confluent cell culture technique and compared against conventional monolayer cell cultures
in normoxic and hypoxic (pO2 not more than 1%) conditions. The antiproliferative effects of terrein were assessed using
sulforhodamine-B assay. In monolayer of SW620 cells, terrein had IC50’s of 34.79 µM and 27.48 µM under hypoxic and
normoxic conditions, respectively. In the three-dimensional model of SW620 cells, terrein had IC50’s of 40.85 µM and
47.92 µM under hypoxic and normoxic conditions, respectively. In monolayer of HT29 cells, terrein had IC50’s of 112.93
µM and 83.21 µM under hypoxic and normoxic conditions, respectively. In the three-dimensional model of HT29, terrein
had IC50’s of 178.99 µM and 64.503 µM under hypoxic and normoxic conditions, respectively. In SW620, the hypoxic
state had no influence on gemcitabine’s IC50 values in the three-dimensional model compared to the monolayer system;
however, preferential antitumor activity was observed in the monolayer system for terrein under normoxic conditions. In
conclusion, multicellular resistance of colorectal cancer cells to terrein is a determining factor for its anticancer activity which
mandates further Intratumoral pharmacokinetics investigation.
Poster ID: 167
Main Author: Fawziah Al-Mutairi
Co-Authors: Khalil Al-Majed, Saad Al-Obaidy, Saleh Al-Anazi, Asma Al-Toub
Institution: King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
REDUCING THE NUMBER OF RETURNED PATIENT BACK TO CLINIC BY
(GREEN SLIP) AT KING ABDULAZIZ MEDICAL CITY (KAMC) - RIYADH
Background: Green slip is a Pharmacy to Nursing and Physician Communication form used by outpatient & emergency care
center (ECC) Pharmacy to get correct, legible and complete prescriptions as per KAMC hospital policy. When pharmacist
indicates inappropriate order and communicated with the prescriber by bleeping three times but not responding, patient will
be sent back to the clinic with green slip contains required information. As a result, medication management was delayed and
some patient went home without their medications. Our objective is to ensuring better communication between pharmacy
and physicians by limiting returning the patients back to the clinic (green slip) to deliver best patient care outcome, minimize
time wasted and eliminate the pending prescriptions
Method: Data collected from King Abdulaziz Medical City (KAMC) Safety Reporting System (SRS) to analyze the number
of returned patients and their pending orders. Fishbone diagram and voting used as quality tools to identify the causes of
problem. Interventions implemented by PDSA model.
Results: The interventions succeeded in decreasing number of returned patients to the clinic with green slip. During January
2019 to March 2020 the reported numbers were (46) and after interventions it reduced to (22) from July 2020 to December
2020.
Conclusion: Multidimensional interventions were associated with a reduction returning patients back to clinic. Sustaining the
change requires continued monitor of the process, audit, and active staff involvement.
Poster ID: 172
Main Author: Samiullah Shabbir
Co-Authors: Samiullah Shabbir, Judit E. Don, Fathima S. Kather, Ishaaq A. Bagnan, Ahmed M. Al-Abd
Institution: Gulf Medical University, Ajman, United Arab Emirates
ANALYZING THE PATHOPHYSIOLOGICAL IMPACT OF SEVERAL PROGRAMMED
CELL DEATH MECHANISMS ON CANCER CELLS: APOPTOSIS, AUTOPHAGY,
METHUOSIS, FERROPTOSIS AND LYSOSOMAL PERMEABILIZATION
Programmed cell death is a crucial physiological and pathological process. Apoptosis is the most common type of programmed
cell death during which unwanted cells are eliminated during early development. In adults, it eliminates damaged or
genetically modified cells such as cancer cells. Inhibited apoptosis would result in uncontrolled cell division and development
duphat.ae 19of malignancies. Autophagy is the second most common type of programmed cell death with a controversial role in physiology
and pathology. It comprises a natural intracellular digestion mechanism of unwanted organelles which plays an important
role in maintaining cellular integrity, recycling its components and providing cellular cleansing machinery. Autophagy is an
essential process for cell survival during stress conditions such as starvation and hypoxia. In neoplastic disorder, autophagy
might reduce cancer progression but helps cancer cells to escape apoptosis and survive in nutritionally deprived conditions.
Methuosis (methuo: “to drink to intoxicationâ€) is a unique type of non-apoptotic programmed cell death that is caused
by alterations to the clathrin-dependent endosomal trafficking, which then leads to the inevitable cell rupture due to extreme
fluid vacuolization. Various cancer cell lines treated with 3-(2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one (MIPP)
and 3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one (MOMIPP) showed significant reduction in
viability due to vacuolation. Ferroptosis is another Iron and Reactive oxygen species (ROS) dependent programmed cell
death. It plays a central role in the depression of tumorigenesis and treatment of tumor drug resistance. Yet, with low
doses of the ferroptosis inducing agent, Erastin significantly increased the anticancer properties of chemotherapies like
cytarabine and doxorubicin in the treatment of acute myeloid leukemia. Lysosomal permeabilization is another programmed
cell death mechanism resulting in the release of cathepsins and enzymes from the lysosomal lumen into the cytosol. It is
followed by a cascade of activation for several proteolytic molecules like Bid and MOMP (Mitochondrial outer-membrane
permeabilization), resulting in cytochrome c release and caspase activation. In conclusion, strategies utilizing one or more of
the previously mentioned programmed cell death can change the future of anti-cancer drug discovery.
Submission ID : 173
Main Author: Faisal Sehli
Co-Authors: Laila Carolina Abu Esba , Maram Aljohani, Rama Aldekheal
Institution: King Abdelaziz Medical City
RISK FACTORS ASSOCIATED WITH DEVELOPMENT OF CHOLESTASIS IN SAUDI
ARABIA INFANTS ON PROLONGED PARENTERAL NUTRITION:
A RETROSPECTIVE CHART REVIEW STUDY
Introduction: Many studies demonstrated that there are many causes behind developing Parenteral nutrition-associated
Cholestasis (PNAC). Aim: our objective was to determine the incidence of cholestasis and evaluate the relationship between
dextrose, protein, and lipids dose and PNAC in infants. Methods: A retrospective chart review was done between January
2010 and December 2015 on infants (less than 12 months) admitted to the neonatal intensive care unit at King Abdul-
Aziz Medical City who received PN for more than 30 days and divided into Cholestasis and non-cholestasis groups based
on the value of direct serum bilirubin. Results: Among 107 patients, 37 had cholestasis (incidence 34.6%) and 5.6 % were
experiencing sepsis before cholestasis. Regarding the components of TPN: No differences were observed between patient
received different doses of amino acids, intra-lipids and dextrose thus, the incidence of cholestasis was 6% higher among
patients who received a higher dose of dextrose (GIR >14 mg/kg/min).Conclusion: These results suggest that dextrose,
protein, and lipids dose isn’t related to cholestasis in infants on prolonged parenteral nutrition, we have to increase the
sample size to confirm the hypothesis. Keywords: Cholestasis, incidence, prolonged parenteral nutrition, PNAC, Saudi Arabia.
Poster ID: 180
Main Author: Nada Saud Alosaimi
Co-Authors: Prof. Mai Abdul Alim Abdul Sattar Ahmad, Dr. Huda Mohammed Alkreathy
Institution: King Abdulaziz University, Jeddah, Saudi Arabia
POTENTIAL CURATIVE EFFECT OF TOPICAL 1α,25-DIHYDROXYVITAMIN D3
VERSUS TOPICAL BETAMETHASONE ON IL-5, IL-4 AND IL-13 CYTOKINES ON
OVALBUMIN-INDUCED ATOPIC DERMATITIS MICE
Background and objective: Atopic dermatitis (AD) is a common, relapsing, and long-lasting inflammatory skin disease. Its
treatment often consumes time and cost. Moreover, the long-term use or abuse of current medications as corticosteroids
20 DUPHAT 2021 | PROFESSIONAL POSTERSlead to several adverse effects. Vitamin D had been studied in various inflammatory diseases. AD is characterized by elevated
production of Th2 cytokines such as IL-4, IL-5, and IL-13 in the acute stage of AD, whereas IL-4 and IL-13 levels are decreased
in the subacute or interphase stage. On the other hand, Th1 cytokines as IL-5 are predominant in the AD's chronic stage. Thus,
the present study aimed to investigate the anti-inflammatory effect of topical 1α,25-dihydroxyvitamin D3 (active form) in
ovalbumin (OVA)-induced AD mice versus topical betamethasone.
Material and Methods: AD was induced in BALB/c mice models using OVA, a chicken egg white protein. The mice were
randomly divided into five groups as follows: the normal control, OVA-induced AD, OVA-induced AD + vehicle, OVA-induced
AD + vitamin D3 cream treated (prepared in our labs), and OVA-induced AD + betamethasone cream treated groups.
Moreover, the levels of Th2 cytokines (IL-5, 4, and 13) were measured.
Results: 1α,25-dihydroxyvitamin D3 showed a significant decrease (P < 0.001) in the IL-5 level, and a significant increase (P
< 0.001) in the IL-4 and -13 levels compared to the OVA-induced AD group. Furthermore, a non-significant difference was
shown in the 1α,25-dihydroxyvitamin D3 treated group versus the standard control drugs (betamethasone).
Conclusion: To our knowledge, there is no single experimental study in Saudi Arabia that treats AD with the active form of
prepared topical vitamin D3 and correlates the results with AD stages. Our findings shed a light on the importance of vitamin
D3 in AD treatment and open a new window for studying more correlations between AD inflammatory cytokines, depending
on AD stages, and the potential effect of vitamin D3 on them.
Poster ID: 201
Main Author: Basmah Al-babtain
Co-Authors: Ejaz Cheema, Muhammad Abdul Hadi
Institution: Princess Nourah Bint Abdulrahaman University and University of Birmingham, Riyadh, Saudi Arabia
IMPACT OF COMMUNITY-PHARMACIST-LED MEDICATION REVIEW
PROGRAMMES ON PATIENT OUTCOMES: A SYSTEMATIC REVIEW AND META-
ANALYSIS OF RANDOMISED CONTROLLED TRIALS
Background: The role of pharmacists has evolved over the past few decades from being product-centred to being patient-
centred. Unique community-pharmacist-led medication review programmes have been commissioned in different countries
under different names. The services provided by general pharmacists can have a positive impact on patient health, but the
impact of the services offered by community pharmacists is relatively unknown.
Objective: To evaluate the effectiveness of community-pharmacist-based medication review programmes among patients
with long-term conditions. Methods: The electronic databases Cochrane Library, MEDLINE and Embase were searched from
their inception until January 2020 for randomised controlled trials (RCTs) published in the English language assessing the
effectiveness of community-pharmacist-led medication review programmes on patients’ clinical and healthcare utilisation
outcomes. Random-effects meta-analysis was used to pool data statistically, where applicable. The study protocol was
published in PROSPERO (ID: CRD42020165693).
Results: Forty-two reports of 40 RCTs were included in the systematic review, and 12 RCTs were included in the meta-analysis.
Compared to the control, a significant improvement was noted in the community-pharmacist-based medication review group
for the following outcomes: blood pressure (BP) in patients with diabetes (mean difference [MD] in systolic blood pressure
[SBP]: -6.82 [95% CI -11.33, -2.32]; MD in diastolic blood pressure [DBP]: -2.13 [95% CI -3.35, -0.92]) and in the hypertension
patients (MD in SBP: - 6.21 [95% CI -13.26, 0.85]; MD in DBP: -2.11 [95% CI -6.47, 2.26]), HbA1c in patients with diabetes
(MD -0.61; 95% CI -0.96, -0.25), and total cholesterol (TC) in patients with hyperlipidaemia (MD -0.18; 95% CI -0.32, -0.05).
Conclusion: Community-pharmacist-led medication review can improve certain clinical and healthcare utilisation outcomes
in patients with long-term conditions.
duphat.ae 21Submission ID : 205
Main Author: Esraa Kamaleldine Eltayeb
Co-Authors: Dr. Fadilah Sfouq Aleaniazy, Dr. Fulwah Yahya Alqahtani, Dr. Hamad Alkahtani
Institution: King Saud University
NOVEL DESIGN OF QUORUM SENSING INHIBITORS LOADED ALGINATE
NANOPARTICLES AS ANTIMICROBIAL AGENTS AGAINST PATHOGENIC
PSEUDOMONAS AERUGINOSA
Background: The emergence of antibiotic-resistant strains of P. aeruginosa is a major concern in public health and is
associated with many virulence factors. P. aeruginosa not only secrete alginate as a major virulence factor but also alginate
can be utilized as nutritional material. Another key factor is the cell-to-cell communication known as quorum sensing
(QS) that regulates virulence and colonization as well as multidrug resistant behavior. QS system was inhibited by small
molecules known as quorum sensing inhibitors (QSI). Alongside published research regarding development of QSI and
their effect against virulent bacteria in particular meta-bromo-thiolactone (mBTL) that showed the maximum efficacy of QS
inhibition. This study aimed to prepare alginate nanoparticles (CANPS) loaded with mBTL and characterize for antibacterial
activity. Methods: mBTL-loaded-CANPS were prepared by emulsification method. Particle size (PZ), polydispersity index
(PDI), and zeta potential (ZP) of Prepared NPs were characterized, and antibacterial activity against P. aeruginosa was
evaluated using dilution methods. Biofilm production, cytotoxic effect and bacterial adhesion to A549 lung epithelial cell
of mBTL-loaded-CANPs was investigated. Results: The average PZ of Formulated NPs were 175.45 nm ± 7.25, with PDI
values of 0.3 ± 0.0045 and ZP of -45.7 ± 0.9201, respectively. The in vitro release showed mBTL released after 5 days
displaying sustained release profile. mBTL-loaded-CANPs exhibited significant antibacterial activity against P. aeruginosa
with minimum inhibitory concentration (MIC) of 0.5mg/ml. The mBTL has shown reduction biofilm by 52%, when mBTL
loaded into the CANPs it showed more reduction if biofilm by 87% which indicate that the bacteria have uptake the
alginate and blinded with its content. No significant cytotoxic effect of mBTL-loaded-CANPs on A549 lung epithelial cell
also bacterial adhesion to these cells was reduced at MIC. In conclusion, mBTL-loaded-CANPS demonstrated potential
antimicrobial drug delivery system against pathogenic P. aeruginosa and would overcome resistance.
Poster ID: 206
Main Author: Jumana Mohamed Fouad Al-Salloum
Co-Authors: Syed Wasif Gillani, Fiayz Ahmed, Shabaz Mohiuddin Gulam
Institution: Gulf Medical University, Ajman, United Arab Emirates
AZITHROMYCIN VERSUS CLARITHROMYCIN IN COMBINATION WITH BETA-
LACTAMS FOR COMMUNITY ACQUIRED PNEUMONIA IN HOSPITALIZED
ADULTS
BACKGROUND: The Global incidence of CAP in adults is estimated to be 4.63 per 1000 persons/year and is associated with
higher rates of mortality and morbidity worldwide. Streptococcus pneumonia is the commonly infecting organism followed
by Staphylococcus aureus, however; the multi-drug resistant organisms have increased the concerns about the appropriate
selection of the antibiotic. The new recommendation by the IDSA highlights the use of combination of beta-lactam with
either a macrolide or fluoroquinolone as empirical therapy for hospitalized patients with CAP. Macrolides monotherapy is
not recommended in the areas with higher rates of microbiological resistance. However, combination therapy of beta-lactams
with macrolide increases the survival rate of patients with severe community acquired pneumonia. Among these macrolides,
azithromycin and clarithromycin are most commonly used. The aim of this study is to identify the superior treatment in terms
of effectiveness when treating hospitalized patients with CAP using Beta-lactams in combination with Azithromycin or
Clarithromycin
METHODS: The reviewers independently searched for articles published in PubMed, Google Scholar and pharmacy based
journals. Reference lists were also used to yield results. RCTs and observational studies that focused on combination therapy
of beta-lactams with azithromycin or clarithromycin were included. Meta-analysis and systematic reviews and studies with
monotherapy of macrolide were excluded.
22 DUPHAT 2021 | PROFESSIONAL POSTERSRESULTS: Total of 10 studies were selected for this review, with total of 2070 patients. No significant difference was found
between both regimens since clinical success was achieved with 82% & 83% in BL-C and BL-Z, respectively. Median LOS was
found to be 8.9 days in BL-C group and 7.5 days in BL-Z group. Patients treated with Azithromycin combination had lower
rates of mortality at 30 days (4.1%) when compared to Clarithromycin combination (8.3%). Both treatments showed equal
incidences of ADRs of 11.8% with BL-C and 14.1% with BL-Z; diarrhea being the major adverse event.
CONCLUSION: We conclude that, no regimen is superior to the other in terms of efficacy and clinical success. However,
higher mortality rates were noted with clarithromycin based combination. Therefore further studies with larger population
size are needed.
Submission ID : 209
Main Author: Safia Sharif
Co-Authors: Guirguis A, Fergus S, Schifano F
Institution: University of Hertfordshire
THE USE AND IMPACT OF COGNITIVE ENHANCERS AMONG UNIVERSITY
STUDENTS; A SYSTEMATIC REVIEW
Introduction: Cognitive enhancers (CEs), also known as ‘smart drugs,’ ‘study aids’ or ‘nootropics’ are a cause of concern.
Recent research studies investigated the use of CEs used as study aids by university students. Despite being illegal in
most countries, the diverted non-prescription use of these molecules and the related potential for dependence and or
addiction is being reported. It has been demonstrated that healthy students (i.e. without any diagnosed mental disorders)
are increasingly using drugs such as methylphenidate, a mixture of dextroamphetamine/amphetamine, and modafinil for the
purpose of increasing their alertness, concentration or memory.
Aim: to investigate the level of knowledge, perceptions and impact of the use and impact of a range of CEs within Higher
Education institutions.
Methodology: A systematic review was here performed, in adherence with the PRISMA (Preferred Reporting Items for
Systematic Reviews and Meta-Analyses) guidelines. Whilst 1400 studies were here identified through a variety of electronic
databases (e.g. 520 through PubMed, 490 through Science Direct and 390 through Scopus), 46 papers were here deemed
as relevant and were included in this review. Results: Most popular molecules here being identified included the stimulant
CEs, e.g. methylphenidate, modafinil, amphetamine mixtures and caffeine-related compounds. Stimulant CE’s intake was
more prevalent among males than females; drugs were mainly obtained from friends and family, as well as from the Internet.
Discussion: It appeared from here that CEs are increasingly being used among healthy individuals, mainly students without
any diagnosed cognitive disorders, to increase their alertness, concentration or memory, in the belief that they will improve
their performance during examinations or when studying. Impact of stimulant CEs may include tolerance, dependence,
cardiovascular neurological issues.
Key words: Neuroenhancement, Cognitive enhancement, Substances of abuse, University students, Study drugs, non-
medical use smart drugs.
Poster ID: 210
Main Author: Nameh Yousef Ower
Co-Author: K.V.R.N.S.Ramesh
Institution: RAK Medical and Health Sciences University, Fujairah, United Arab Emirates
COMPARATIVE EVALUATION OF SOLID DISPERSION AND INCLUSION
COMPLEXATION FOR DISSOLUTION ENHANCEMENT OF POORLY SOLUBLE DRUGS
Background: Usage of the drug in its amorphous form has become the method of choice to overcome oral bioavailability
problems of poorly soluble drugs due to its solubility advantage when compared to the crystalline form. But, one major
duphat.ae 23problem associated with the usage of the drug in its amorphous form is its high physical instability, where it tend to revert back
to its crystalline form. So the method and the polymers used in the development of amorphous forms should ensure stability
of the drugs both in the pre-formulation and formulation stage as well.
In the present investigation, two poorly soluble drugs, indomethacin and furosemide were employed as model drugs to
evaluate the efficacy of the solid dispersion and inclusion complexation methods. Combination of polymers were employed
to prepare the solid dispersions and the inclusion complexes to find out their suitability for preparing the fast dissolving and
stable products of the two selected drugs.
The solid dispersions and inclusion complexes were comparatively evaluated with respect to their ability to enhance the
dissolution of the selected drugs.
Aim: To prepare and evaluate solid dispersion and inclusion complexes of two poorly soluble drugs indomethacin and
furosemide.
Methods: Binary and ternary solid dispersions and inclusion complexes of the two poorly soluble drugs, indomethacin and
furosemide, were prepared by different methods using different polymers, and the dissolution of the formed products was
evaluated. Then, tablets were formulated with the prepared inclusion complexes or dispersions and evaluated
Conclusions: The dissolution of the two drugs was found to be enhanced in the inclusion complexes and solid dispersions . The
two drugs are found to be converted into amorphous form and the formulated tablets exhibited satisfactory pharmaceutical
characteristics.
Poster ID: 212
Main Author: Rana Kamran Mahmood
Co-Authors: Syed Wasif Gillani, Muhammad Waqas Saeed, Jumana Mohamed Al-Salloum, Prasanna Vippadapu
Institution: Gulf Medical University Ajman, Abu Dhabi, United Arab Emirates
CHARACTERISTICS OF PRIMARY LITERATURE IN THE FIELD OF ANTIFUNGAL
STEWARDSHIP, 2010-2020
Background: Fungal infection and resistance are increasing specially in immune-compromised patients. It has been observed
that practical implementation of antifungal stewardships not only reduce the resistance but the cost, length of stay and timely
diagnosis.
Objectives: Objective of this review is to collect all stewardship plans in field of antifungal and extract the data that can be
used in future to develop guidelines and starting antifungal stewardship plans.
Methodology: The source used to search primary literature is Pubmed from year 2010 to 2020 with key search “Antifungal
stewardshipâ€. Articles are assessed and data is collected and arranged.
Results: There are total 36 antifungal stewardship plans from 2010 till October 2020, most in 2019. Most of studies took
place in UK (7), Spain (6), America (5) and Australia (4). 5 out of 36 studies published in Journal of Antimicrobial Chemotherapy.
14 Prospective, 13 retrospective studies are mostly conducted with 3 quasi-experimental as well. 15 out of 36 studies led by
pharmacist. Most of studies are conducted in tertiary care hospital (9) and tertiary teaching hospitals (9). 15 studies show the
cost effectiveness of 21,076 US dollars per year to maximum 2,023,561 US dollars per year. Candida infection is studied in
18 literatures and most common candida infection is Candidemia and most common candida specie is Candida albicans. 13
different types of strategies are being used for example guidelines, education, step up step down, diagnostic testing etc.
Conclusion: It is concluded that studies in European Countries, America and Australia shows there is need of stewardship
plan in Asian countries. These strategies can be used in tertiary hospitals with multiple care departments that can not only
reduce the hospital stay, resistance but the cost of treatment as well.
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