What's the market pull for E-Health? - Presentation at 9th Berlin Conference on IP in Life Sciences - Digital Health Solution
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What’s the market pull for E-Health? Presentation at 9th Berlin Conference on IP in Life Sciences – Digital Health Solution 12th February 2016
There is clearly a market pull towards digitalization, across industry and in healthcare Digitalization is disrupting traditional industries… …and creates strong pull in healthcare 233.3 +21% 135.9 233.3 73.2 135.9 73.2 2014 2017 2020 Digital health market [bn USD] Source: Roland Berger team analysis What’s the market pull for E-Health.pptx 2
Across industries, a technological and a sociological revolution are under way Trend overview A TECHNOLOGICAL A SOCIOLOGICAL REVOLUTION REVOLUTION TECHNOLOGY ADVANCES CONSUMER/PATIENT BEHAVIOR CHANGES > The world is connected via the internet DIGITAL > Consumers/patients have increasing access to transparent > Powerful computing & communication devices are increasingly mobile TRANSFORMATION information > The 'informed patient' is transforming to the 'participating patient' DATA VOLUME BIG DATA CHANGES START-UP ACTIVITIES INCREASES TRADITIONAL BUSINESS INCREASE > More and more digital data is > Existing businesses must identify generated the value of data for their industry > VCs believe in business if they want to be sustainable in models that are designed > The belief in mutual enrichment by the future for this new environment exchange fuels data sharing Source: Roland Berger What’s the market pull for E-Health.pptx 3
The major challenge in modern medicine is the interpretation of enormous amounts of data within human biological networks Holistic approach to studying complex biological systems Multi-Omics Complexity and variability of humans Systems medicine > Systems medicine evolved from systems biology – Systems biology is the study of systems of biological components, which may be Organisms Populations molecules, cells, organisms or entire species … – Systems biology is pioneering actionable understandings of disease and wellness as a continuum of network states unique in time Organs 50 organs and space to each individual human being Microbiome 100 trillion cells > Systems medicine aims at better understanding Cytome Cells processes within the human body at molecular Metabolome level and its interactions 20,000 proteins Proteome > The major challenge for systems medicine is to Molecules find the significant signals within this enormous Transciptome 35,000 orfs Epigenome amount of individual data and enhance the signal- Genome 6 bn nucleotides to-noise ratio Genes Source: Hood and Flores; Naylor and Chen; Roland Berger What’s the market pull for E-Health.pptx 4
In our view, winning Digital Health offerings must fulfill a clear set of principles to make it attractive Principles of winning Digital Health offerings Follow customer journeys – target specific interactions in the healthcare system Interaction Connect all stakeholders across the healthcare system Overcome disconnect between healthcare provider and patient Value-added Use smart solutions, offer tangible value added: time, money, quality, outcomes Platform/ Get the initial patient connection right - ubiquitous digital channels: Social media, website, apps connectivity as touch points (mobile network of connectivity) Take advantage of comprehensive user data Data Ensure accessibility and security e-Health Gather meaningful insights Intelligence Offering Use Big Data to become predictive, not reactive Use multiple interfaces to suit the patients‘ lifestyle Device Link with technology standards and build closed loop system Give precise measurements Sensor Considers patient convenience with e.g. wearable sensors Add new technology dimension to core product Pharmaceutical Enhance value proposition beyond the molecule Reflect regulatory & care environment Regional Understand and accept local pain points – adjust technology and value added Source: Roland Berger Team What’s the market pull for E-Health.pptx 5
Market pull is mainly driven by new entrants, consumers, insurances, government and industry – players move to the right Market pull of selected healthcare players – European perspective Pharmacy Pharma Healthcare • Reluctant since • Opportunities across Industry – fear of e-prescriptions the value chain Medtech New entrants – investment needed • Different priorities • Some segments • Development of new • Some see opportunity to shape digitalization business models and drive compliance/ adherence more than others partnerships Government • Embraces Patients/ Consumers Public sector • Hybrids with increasing opportunities to increase transparency digital habits and efficiency • Information needs Statutory insurances Payer • Strong interest in Private insurances transparent information organizations and improved patient • Positive but cautious • Limited market power care at lower cost Office based physicians • Doubts concerning Public Private Providers – patient/ doctor relation Providers Care provider • Reluctant concerning • Promising potential – data security/ protection to improve patient pathways – medical independence investment needs and efficiencies Reluctant Neutral Pushing Attitude towards e-Health Source: Roland Berger Analysis What’s the market pull for E-Health.pptx 6
Industrial healthcare players identifying opportunities across the value chain Industrial value chain Smart data Industry 4.0 Digital health Multichannel management Pharma Manufacturing / Medical / Company R&D Sales Supply chain Marketing Industry 4.0 Digital health Digital tool Multichannel management Smart data > Biotech > KOLs > Suppliers > Physicians > Hospitals > Consumer > Payers Target > Clinical > Patients > Technical service > Payers > Patient > Patient > Hospitals groups centers providers groups > KOLs > Pharmacies > Diagnostics > Consumers Source: Roland Berger What’s the market pull for E-Health.pptx 7
R&D Roche decided to exploit the market potential stemming from digitalization mainly in the R&D area Roche's strategic transaction regarding Foundation Medicine R&D approach > Focus of the R&D collaboration will be on developing genomic profile tests for cancer immunotherapies and for continuous blood-based monitoring > Roche will be able to utilize FMI’s > In 2015, Roche acquired a majority stake in Foundation Medicine, a new player proprietary molecular information in the field of molecular information in oncology platform to standardize clinical trial > FMI supports physicians by providing comprehensive molecular information to testing characterize a tumor that is being matched with approved targeted therapy > Roche aims for comparability of options and novel treatments under development clinical trial results for R&D > Collaboration leverages both companies’ strengths to advance the progress of purposes to improve decision personalized treatments for patients with cancer making and support optimization of patient care as oncology > The partnership includes both a broad R&D collaboration with the potential for management becomes more more than USD 150 million funding by Roche to accelerate FMI’s new product complex development as well as commercial collaboration agreements aimed at expanding the global sales efforts for FMI’s current and future products > Digitalization will further link R&D with real life treatment data Source: Roland Berger, Roche press releases What’s the market pull for E-Health.pptx 8
Mfg. / Supply chain New technologies have the potential to disrupt the Medtech and Pharma manufacturing world Selected Industry 4.0 technologies and use cases Virtual Manufacturing Additive Manufacturing Predictive maintenance Cyber physical systems > 3D CT data and the NX- > In March of 2015, 3D > ThyssenKrupp uses Microsoft > On the assembly line at the CAD/CAM software from Bioprinting Solutions became predictive analytics Bosch Rexroth plant Siemens PLM enable the first group to software for its elevator Homburg / Saar, an RFID simulation and design of successfully bioprint and maintenance support chip on the work piece customized and patient- transplant a thyroid gland > Elevators are connected to a steers its own production specific artificial joints with for a mouse cloud and transfer data from steps through nine intelligent still a high degree of process sensors to the system for work stations chain automation predictive and even > Displays show the employees preemptive maintenance the appropriate work instructions Source: Roland Berger analysis What’s the market pull for E-Health.pptx 9
Medical / Marketing Digital offerings are manifold and will change the way how people are treated tremendously – Pharma’s offerings will be impacted Bayer Apple Health BETACONNECT™ 23 and me Proteus digital > Currently focuses on > Prescribes injection > FDA and CE approval > Available in the USA collection of health and reminders, injection depth > DNA analyzer that enables > Marketed as an intelligent fitness information from third- and speed based on patient users to learn about and medicine platform integrating party apps preferences explore their DNA patients, patients’ relatives > Glucose monitor in > Stores and shares injection > Extrapolates ancestry reports and treating doctors development using non- information (date, speed, and raw data from its > Includes wearable and invasive sensors volume) and symptoms and database ingestible sensors > Takes advantage of syncs live with smartphone app > Future use for health-related > Developed in cooperation pedometer, blood pressure, genetic information with Novartis and Otsuka hydration and heart rate > Shares the data with anticipated Pharmaceuticals screening healthcare providers via an online dashboard > FDA application for first drug/device combination > FDA approval in 09/2015 (ABILIFY) ongoing Source: Roland Berger What’s the market pull for E-Health.pptx 10
Sales Digitalization within healthcare sector gives birth to new business models enabling self-monitoring, higher efficiency & convenience Major Digital Health trends Quantified health Tele-health Medication online e.ventures "Wearables becoming "Extending the "Pharmacy reinvented" says: smarter" point of care" > Tracking of physical activity and other > Telemedicine services connecting patients > Simplified process of getting health indicators due to rise of wearable directly with doctors via video allow for prescriptions or receiving medication technologies and sensors higher convenience at lower costs through faster submission technologies > Features of new devices going beyond fit- > Monitoring of at-risk patients simplified ness and are more sophisticated than ever especially in the field of chronic diseases Record memories on the go Online connection to your doctor Online pharmacy Activity & diet Fitness & sports tracking Tele-health platform connecting doctors & patients activity tracking Source: e.ventures; Roland Berger What’s the market pull for E-Health.pptx 11
So for moving forward – what are the guiding questions to be answered? What are the drivers and hurdles for digital transformation of Pharma and Healthcare and how does it change the paradigm in modern medicine? Where is the potential of the new paradigm in modern medicine and how can digital transformation help unlock this potential? Which new business models emerge from the associated digital transformation? How can the opportunities arising from digital transformation in pharma and healthcare be addressed? What’s the market pull for E-Health.pptx 12
Strategic collaboration will become more important than ever for established players to succeed in the new business environment Conclusion Challenges > Implement out-of-the-box innovation into a highly regulated environment > Combine development cycles and know-how from IT and medicine > Open up for partnerships Strategic cooperation to face > Achieve quick wins to keep going new business reality > Pharma Exemplary partnerships and initiatives of > Medtech established Pharma players with other industries > IT > Google and Sanofi collaborate in > Consumer industries Diabetes Care > Telecommunications > Roche acquires Big Data platform Bina Technologies for next generation sequencing Source: Roland Berger What’s the market pull for E-Health.pptx 13
On our first "Digital Health Day" on February 25th at spielfeld we are connecting industry leaders with promising start-ups "Digital Hub" in Berlin Digital Health Day Strong network of digital- Several top-companies > Senior executives will meet innovative /tech-partners and start- working on digital ups projects, curated by RB start-ups to discuss disruptive and successful business models 1,000m2 multi-functional Digital Academy > Clients will have the opportunity to space develop own ideas through an idea Broad portfolio of services generation workshop, and to develop from inspiration formats to Big/Smart Data Lab and implement concepts in follow-on prototyping and change projects projects > Selected participants: Source: Roland Berger What’s the market pull for E-Health.pptx 14
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