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TOTAL PRODUCTION
Nom de l’unité / de l’équipe : Inserm U1162 « Génomique fonctionnelle des tumeurs solides
Acronyme : FUNGEST
Nom du directeur pour le contrat en cours : Jessica Zucman-Rossi
Nom du directeur pour le contrat à venir : Jessica Zucman-Rossi
I. PRODUITS DE LA RECHERCHE
Publications made in collaboration with other teams of the CRC are flagged with ■
Publications of staff recruited during the last five years and done in their previous team are flagged
with ✏
1. Journaux / revues
Articles scientifiques
2017-1. Nahon P, Bourcier V, Layese R, Audureau E, Cagnot C, Marcellin P, Guyader D, Fontaine H, Larrey D, De Lédinghen V,
Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki JP, Zarski JP, Leroy V, Riachi G, Calès P, Péron JM, Alric L, Bourlière M,
Mathurin P, Dharancy S, Blanc JF, Abergel A, Serfaty L, Mallat A, Grangé JD, Attali P, Bacq Y, Wartelle C, Dao T, Benhamou Y,
Pilette C, Silvain C, Christidis C, Capron D, Bernard-Chabert B, Zucman D, Di Martino V, Thibaut V, Salmon D, Ziol M, Sutton A,
Pol S, Roudot-Thoraval F; ANRS CO12 CirVir Group. Eradication of Hepatitis C Virus Infection in Patients With Cirrhosis Reduces
Risk of Liver and Non-Liver Complications. Gastroenterology. 2017 Jan;152(1):142-156. IF=18.3
2017-2. Nault JC, Couchy G, Balabaud C, Morcrette G, Caruso S, Blanc JF, Bacq Y, Calderaro J, Paradis V, Ramos J, Scoazec JY,
Gnemmi V, Sturm N, Guettier C, Fabre M, Savier E, Chiche L, Labrune P, Selves J, Wendum D, Pilati C, Laurent A, De Muret A, Le
Bail B, Rebouissou S, Imbeaud S; GENTHEP investigators., Bioulac-Sage P, Letouzé E, Zucman-Rossi J. Molecular Classification of
Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation. Gastroenterology. Mar;152(4):880-
894. 2017. IF=18.3
2017-3. Tranchant R, Quetel L, Tallet A, Meiller C, Renier A, de Koning L, de Reyniès A, Le Pimpec Barthes F, Zucman-Rossi J,
Jaurand MC, Jean D. Co-occurring mutations of tumor suppressor genes, LATS2 and NF2, in malignant pleural mesothelioma. Clin
Cancer Res. 2017, Jun 15;23(12):3191-3202. IF=9.6
2017-4. Nahon P, Lescat M, Layese R, Bourcier V, Talmat N, Allam S, Marcellin P, Guyader D, Pol S, Larrey D, De Lédinghen V,
Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki JP, Zarski JP, Goria O, Calès P, Péron JM, Alric L, Bourlière M, Mathurin P,
Blanc JF, Abergel A, Serfaty L, Mallat A, Grangé JD, Attali P, Bacq Y, Wartelle C, Dao T, Benhamou Y, Pilette C, Silvain C,
Christidis C, Capron D, Bernard-Chabert B, Hillaire S, Di Martino V, Trinchet JC, Moreau R, Roudot-Thoraval F; ANRS CO12 CirVir
and Microcir Groups. Bacterial infection in compensated viral cirrhosis impairs 5-year survival (ANRS CO12 CirVir prospective
cohort). Gut. 2017 Feb;66(2):330-341. IF=16,6
2017-5. Rebouissou S*, La Bella T, Rekik S, Imbeaud S, Calatayud AL, Rohr-Udilova N, Martin Y, Couchy G, Bioulac-Sage P,
Grasl-Kraupp B, de Koning L, Ganne N, Nault JC, Ziol M, Zucman-Rossi J. Proliferation markers are associated with MET expression
in hepatocellular carcinoma and predict tivantinib sensitivity in vitro. Clin Cancer Res. 2017 In press. IF=9.6
12017-6. Patitucci C, Couchy G, Bagattin A, Cañeque T, de Reyniès A, Scoazec JY, Rodriguez R, Pontoglio M, Zucman-Rossi J,
Pende M, Panasyuk G. Hepatocyte nuclear factor 1α suppresses steatosis-associated liver cancer by inhibiting PPARγ transcription. J
Clin Invest. 2017 May 1;127(5):1873-1888. IF=12.7
2017-7. Schneider AT, Gautheron J, Feoktistova M, Roderburg C, Loosen SH, Roy S, Benz F, Schemmer P, Büchler MW, Nachbur
U, Neumann UP, Tolba R, Luedde M, Zucman-Rossi J, Panayotova-Dimitrova D, Leverkus M, Preisinger C, Tacke F, Trautwein C,
Longerich T, Vucur M, Luedde T. RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer. Cancer Cell. 2017 In press.
IF=27.4
2017-8. Barge S, Ziol M, Nault JC. Autoimmune-like chronic hepatitis induced by olmesartan. Hepatology. 2017
2017-9. Bourlière M, Rabiega P, Ganne-Carrie N, Serfaty L, Marcellin P, Barthe Y, Thabut D, Guyader D, Hezode C, Picon M,
Causse X, Leroy V, Bronowicki JP, Carrieri P, Riachi G, Rosa I, Attali P, Molina JM, Bacq Y, Tran A, Grangé JD, Zoulim F, Fontaine
H, Alric L, Bertucci I, Bouvier-Alias M, Carrat F; ANRS HB06 PEGAN Study Group. Effect on HBs antigen clearance of addition of
pegylated interferon alfa-2a to nucleos(t)ide analogue therapy versus nucleos(t)ide analogue therapy alone in patients with HBe
antigen-negative chronic hepatitis B and sustained undetectable plasma hepatitis B virus DNA: a randomised, controlled, open-label
trial. Lancet Gastroenterol Hepatol. 2017 Mar;2(3):177-188.
2017-10. Breig O, Yates M, Neaud V, Couchy G, Grigoletto A, Lucchesi C, Prox J, Zucman-Rossi J, Becker-Pauly C, Rosenbaum J.
Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein
Reptin. Oncotarget. 2016 Dec 16 IF=5.1
2017-11. Cadier B, Bulsei J, Nahon P, Seror O, Laurent A, Rosa I, Layese R, Costentin C, Cagnot C, Durand-Zaleski I, Chevreul K;
ANRS CO12 CirVir and CHANGH groups. Early detection and curative treatment of hepatocellular carcinoma: A cost-effectiveness
analysis in France and in the United States. Hepatology. 2017 Apr;65(4):1237-1248.
2017-12. Calderaro J, Couchy G, Imbeaud S, Amaddeo G, Letouzé E, Blanc JF, Laurent C, Hajji Y, Azoulay D, Bioulac-Sage P, Nault
JC, Zucman-Rossi J. Histological Subtypes of Hepatocellular Carcinoma Are Related To Gene Mutations and Molecular Tumour
Classification. J Hepatol. 2017 in press IF=12.4
2017-13. Caruso S, Calderaro J, Letouzé E, Nault JC, Couchy G, Boulais A, Luciani A, Zafrani ES, Bioulac-Sage P, Seror O, Imbeaud
S, Zucman-Rossi J. Germline and somatic DICER1 mutations in familial and sporadic liver tumors. J Hepatol. 2017 In press IF=12.4
2017-14. Costentin CE, Decaens T, Laurent A, Nault JC, Paule B, Letoublon C, Luciani A, Calderaro J, Adam R, Bricault I, Amaddeo
G, Cherqui D, Mallat A, Samuel D, Duvoux C, Ganne-Carrié N, Roudot-Thoraval F, Vibert E. Sorafenib versus surgical resection for
hepatocellular carcinoma with macrovascular invasion: a propensity score analysis. Liver Int. 2017 in press
2017-15. Fan Y, Arechederra M, Richelme S, Daian F, Novello C, Calderaro J, Di Tommaso L, Morcrette G, Rebouissou S, Donadon
M, Morenghi E, Zucman-Rossi J, Roncalli M, Dono R, Maina F. A Phosphokinome-based screen uncovers new drug synergies for
cancer driven by liver-specific gain of non-oncogenic RTKs. Hepatology. 2017 in press
2017-16. Hocquelet A, Aubé C, Rode A, Cartier V, Sutter O, Manichon AF, Boursier J, N'kontchou G, Merle P, Blanc JF, Trillaud H,
Seror O. Comparison of no-touch multi-bipolar vs. monopolar radiofrequency ablation for small HCC. J Hepatol. 2017 Jan;66(1):67-
74.
2017-17. Hocquelet A, Seror O, Blanc JF, Frulio N, Salut C, Nault JC, Trillaud H. Transarterial chemoembolization for early stage
hepatocellular carcinoma decrease local tumor control and overall survival compared to radiofrequency ablation. Oncotarget. 2017
May 9;8(19):32190-32200
2017-18. Le Moyec L, Triba MN, Nahon P, Bouchemal N, Hantz E, Goossens C, Amathieu R, Savarin P. Nuclear magnetic resonance
metabolomics and human liver diseases: The principles and evidence associated with protein and carbohydrate metabolism. Biomed
Rep. 2017 Apr;6(4):387-395.
2017-19. Mueller S, Nahon P, Rausch V, Peccerella T, Silva I, Yagmur E, Straub BK, Lackner C, Seitz HK, Rufat P, Sutton A, Bantel
H, Longerich T. Caspase-cleaved keratin-18 fragments increase during alcohol withdrawal and predict liver-related death in patients
with alcoholic liver disease. Hepatology. 2017 Feb 7. doi: 10.1002/hep.29099.
2017-20. Nguyen A, Moussallieh FM, Mackay A, Cicek AE, Coca A, Pierre Chenard M, Weingertner N, Lhermitte B, Letouzé E,
Guérin E, Pencreach E, Jannier S, Guenot D, Jacques Namer I, Jones C, Entz-Werlé N. Characterization of the transcriptional and
metabolic responses of pediatric high grade gliomas to mTOR-HIF-1a axis inhibition. Oncotarget. 2017 Mar 23.
2017-21. Oussalah A, Avogbe PH, Guyot E, Chery C, Guéant-Rodriguez RM, Ganne-Carrié N, Cobat A, Moradpour D, Nalpas B,
Negro F, Poynard T, Pol S, Bochud PY, Abel L, Jeulin H, Schvoerer E, Chabi N, Amouzou E, Sanni A, Barraud H, Rouyer P, Josse T,
Goffinet L, Jouve JL, Minello A, Bonithon-Kopp C, Thiefin G, Di Martino V, Doffoël M, Richou C, Raab JJ, Hillon P, Bronowicki JP,
Guéant JL, Study Group FT. BRIP1 coding variants are associated with a high risk of hepatocellular carcinoma occurrence in patients
with HCV- or HBV-related liver disease. Oncotarget. 2016 Aug 17. In press
2017-22. Pamoukdjian F, Canoui-Poitrine F, Longelin-Lombard C, Aparicio T, Ganne N, Wind P, Martinez-Tapia C, Audureau E,
Sebbane G, Zelek L, Paillaud E. Diagnostic performance of gait speed, G8 and G8 modified indices to screen for
vulnerability in older cancer patients: the prospective PF-EC cohort study. Oncotarget. 2017 in Press
2017-23. !Pilati C*, Shinde J*, Alexandrov LB*, Assié G, André T, Hélias-Rodzewicz Z, Ducoudray R, Le Corre D, Zucman-Rossi
J, Emile JF, Bertherat J**, Letouzé E**, Laurent-Puig P**. Mutational signature analysis identifies MUTYH deficiency in colorectal
cancers and adrenocortical carcinomas. J Pathol. 2017 in press IF=6.8
2017-24. Roulot D, Roudot-Thoraval F, Nkontchou G, Kouacou N, Costes JL, Elourimi G, Clesiau HL, Ziol M, Beaugrand M.
Concomitant screening for liver fibrosis and steatosis in French type 2 diabetic patients using Fibroscan. Liver Int. 2017 May 27.in
press
22017-25. Saldarriaga J, Bisig B, Couchy G, Castain C, Zucman-Rossi J, Balabaud C, Sempoux C, Bioulac-Sage P. Focal b-catenin
mutation identified on formalin-fixed and paraffin-embedded inflammatory hepatocellular adenomas. Histopathology. 2017 in press
2017-26. Sempoux C, Bisig B, Couchy G, Balabaud C, Zucman-Rossi J, Bioulac-Sage P. Malignant transformation of a b-catenin
inflammatory adenoma due to a S45 ß-catenin activating mutation present 12 years before. Hum Pathol. 2016
2017-27. Sutter O, Calvo J, N'Kontchou G, Nault JC, Ourabia R, Nahon P, Ganne-Carrié N, Bourcier V, Zentar N, Bouhafs F, Sellier
N, Diallo A, Seror O. Safety and Efficacy of Irreversible Electroporation for the Treatment of Hepatocellular Carcinoma Not Amenable
to Thermal Ablation Techniques: A Retrospective Single-Center Case Series. Radiology. 2017 Apr 28:161413.
2017-28. van der Meer AJ, Feld JJ, Hofer H, Almasio PL, Calvaruso V, Fernández-Rodríguez CM, Aleman S, Ganne-Carrié N,
D'Ambrosio R, Pol S, Trapero-Marugan M, Maan R, Moreno-Otero R, Mallet V, Hultcrantz R, Weiland O, Rutter K, Di Marco V,
Alonso S, Bruno S, Colombo M, de Knegt RJ, Veldt BJ, Hansen BE, Janssen HL Risk of cirrhosis-related complications in patients
with advanced fibrosis following hepatitis C virus eradication. J Hepatol. 2017 Mar;66(3):485-493.
2016-1. Rebouissou S*, Franconi A*, Calderaro J, Letouzé E, Imbeaud S, Pilati C, Nault JC, Couchy G, Laurent A, Balabaud C,
Bioulac-Sage P, Zucman-Rossi J**. Genotype-phenotype correlation of CTNNB1 mutations with different ß-catenin activation levels in
liver tumors. Hepatology, 24, 6, 2047-2061, 2016 IF=13.2
2016-2. Beuselinck B, Jean-Baptiste J, Schöffski P, Couchy G, Meiller C, Rolland F, Allory Y, Joniau S, Verkarre V, Elaidi R, Lerut
E, Roskams T, Patard JJ, Oudard S, Méjean A, Lambrechts D, Zucman-Rossi J. Validation of VEGFR1 rs9582036 as predictive
biomarker in metastatic clear-cell renal cell carcinoma patients treated with sunitinib. BJU Int. 2016 Jul 15. doi: 10.1111/bju.13585.
[Epub ahead of print] IF=4.3
2016-3. Calderaro J, Nault JC, Balabaud C, Couchy G, Saint-Paul MC, Azoulay D, Mehdaoui D, Luciani A, Zafrani ES, Bioulac-
Sage P, Zucman-Rossi J. Inflammatory hepatocellular adenomas developed in the setting of chronic liver disease and cirrhosis. Mod
Pathol. 2016 Jan;29(1):43-50. IF=5.7
2016-4. Dauch D, Rudalska R, Cossa G, Nault JC, Kang TW, Wuestefeld T, Hohmeyer A, Imbeaud S, Yevsa T, Hoenicke L, Pantsar
T, Bozko P, Malek NP, Longerich T, Laufer S, Poso A, Zucman-Rossi J, Eilers M, Zender L. A MYC-aurora kinase A protein complex
represents an actionable drug target in p53-altered liver cancer. Nature Medicine. Jul;22(7):744-53. 2016 IF=29.8
2016-5. Ganne-Carrié N, Layese R, Bourcier V, Cagnot C, Marcellin P, Guyader D, Pol S, Larrey D, de Lédinghen V, Ouzan D,
Zoulim F, Roulot D, Tran A, Bronowicki JP, Zarski JP, Riachi G, Calès P, Péron JM, Alric L, Bourlière M, Mathurin P, Blanc JF,
Abergel A, Serfaty L, Mallat A, Grangé JD, Attali P, Bacq Y, Wartelle C, Dao T, Benhamou Y, Pilette C, Silvain C, Christidis C,
Capron D, Bernard-Chabert B, Zucman D, Di Martino V, Trinchet JC, Nahon P, Roudot-Thoraval F; ANRS CO12 CirVir Study
Group. Nomogram for individualized prediction of hepatocellular carcinoma occurrence in hepatitis C virus cirrhosis (ANRS CO12
CirVir). Hepatology. 2016 Oct;64(4):1136-47.
2016-6. Seror O, N'Kontchou G, Nault JC, Rabahi Y, Nahon P, Ganne-Carrié N, Grando V, Zentar N, Beaugrand M, Trinchet JC,
Diallo A, Sellier N. Hepatocellular Carcinoma within Milan Criteria: No-Touch Multibipolar Radiofrequency Ablation for Treatment-
Long-term Results. Radiology. 2016 Aug;280(2):611-21. IF=6.3
2016-7. Simerzin A, Zorde-Khvalevsky E, Rivkin M, Adar R, Zucman-Rossi J, Couchy G, Roskams T, Govaere O, Oren M, Giladi
H, Galun E. The liver-specific miR-122*, the complementary strand of miR-122, acts as a tumor suppressor by modulating the p53-
Mdm2 circuitry. Hepatology. 2016 Jun 15. doi: 10.1002/hep.28679. [Epub ahead of print]in press IF=13.2
2016-8. Allen JC Jr, Nault JC, Zhu G, Khor AY, Liu J, Lim TK, Zucman-Rossi J, Chow PK. The transcriptomic G1-G6 signature of
hepatocellular carcinoma in an Asian population: Association of G3 with microvascular invasion. Medicine (Baltimore). 2016
Nov;95(47):e5263.
2016-9. Amathieu R, Triba MN, Goossens C, Bouchemal N, Nahon P, Savarin P, Le Moyec L. Nuclear magnetic resonance based
metabolomics and liver diseases: Recent advances and future clinical applications. World J Gastroenterol. 2016 Jan 7;22(1):417-26
2016-10. Arrivé L, Zucman-Rossi J, Balladur P, Wendum D. Hepatocellular adenoma with malignant transformation in a patient with
neonatal portal vein thrombosis. Hepatology. Aug;64(2):675-7. 2016
2016-11. Barge S, Grando V, Nault JC, Broudin C, Beaugrand M, Ganne-Carrié N, Roulot D, Ziol M. Prevalence and clinical
significance of nodular regenerative hyperplasia in liver biopsies. Liver Int. 2016 Jul;36(7):1059-66.
2016-12. Bissonnette J, Garcia-Pagán JC, Albillos A, Turon F, Ferreira C, Tellez L, Nault JC, Carbonell N, Cervoni JP, Abdel Rehim
M, Sibert A, Bouchard L, Perreault P, Trebicka J, Trottier-Tellier F, Rautou PE, Valla DC, Plessier A. Role of the transjugular
intrahepatic portosystemic shunt in the management of severe complications of portal hypertension in idiopathic noncirrhotic portal
hypertension. Hepatology. 2016 Jul;64(1):224-31.
2016-13. Desgrees-du-Lou A, Pannetier J, Ravalihasy A, Le Guen M, Gosselin A, Panjo H, Bajos N, Lydie N, Lert F, Dray-Spira R;
PARCOURS Study Group. Is hardship during migration a determinant of HIV infection? Results from the ANRS PARCOURS study
of sub-Saharan African migrants in France. AIDS. 2016 Feb 20;30(4):645-56.
2016-14. Doreille A, N'Kontchou G, Halimi A, Bouhafs F, Coderc E, Sellier N, Seror O. Percutaneous treatment of extrahepatic
recurrence of hepatocellular carcinoma. Diagn Interv Imaging. 2016 Nov;97(11):1117-1123.
2016-15. Ezzoukhry Z, Henriet E, Piquet L, Boyé K, Bioulac-Sage P, Balabaud C, Couchy G, Zucman-Rossi J, Moreau V, Saltel F.
TGF-β1 promotes linear invadosome formation in hepatocellular carcinoma cells, through DDR1 up-regulation and collagen I cross-
linking. Eur J Cell Biol. Nov;95(11):503-512. 2016
2016-16. Goossens C, Nahon P, Le Moyec L, Triba MN, Bouchemal N, Amathieu R, Ganne-Carrié N, Ziol M, Trinchet JC, Sellier N,
Diallo A, Seror O, Savarin P. Sequential Serum Metabolomic Profiling after Radiofrequency Ablation of Hepatocellular Carcinoma
Reveals Different Response Patterns According to Etiology. J Proteome Res. 2016 May 6;15(5):1446-54
32016-17. Guldiken N, Kobazi Ensari G, Lahiri P, Couchy G, Preisinger C, Liedtke C, Zimmermann HW, Ziol M, Boor P, Zucman-
Rossi J, Trautwein C, Strnad P. Keratin 23 is a stress-inducible marker of mouse and human ductular reaction in liver disease. J
Hepatol. 2016 Sep;65(3):552-9.
2016-18. Kamoun A, Idbaih A, Dehais C, Elarouci N, Carpentier C, Letouzé E, Colin C, Mokhtari K, Jouvet A, Uro-Coste E, Martin-
Duverneuil N, Sanson M, Delattre JY, Figarella-Branger D, de Reyniès A, Ducray F; POLA network. Integrated multi-omics analysis
of oligodendroglial tumours identifies three subgroups of 1p/19q co-deleted gliomas. Nat Commun. 2016 Apr 19;7:11263.
2016-19. Laurent A, Dokmak S, Nault JC, Pruvot FR, Fabre JM, Letoublon C, Bachellier P, Capussotti L, Farges O, Mabrut JY, Le
Treut YP, Ayav A, Suc B, Soubrane O, Mentha G, Popescu I, Montorsi M, Demartines N, Belghiti J, Torzilli G, Cherqui D,
Hardwigsen J; AFC-HCA-2013 Study Group. European experience of 573 liver resections for hepatocellular adenoma: a cross-
sectional study by the AFC-HCA-2013 study group. HPB (Oxford). 2016 Sep;18(9):748-55.
2016-20. Le Joncour A, Bidegain F, Ziol M, Galicier L, Oksenhendler E, Mechai F, Boutboul D, Bouchaud O. Hemophagocytic
Lymphohistiocytosis Associated With Bartonella henselae Infection in an HIV-Infected Patient. Clin Infect Dis. 2016 Mar
15;62(6):804-6.
2016-21. Munteanu M, Tiniakos D, Anstee Q, Charlotte F, Marchesini G, Bugianesi E, Trauner M, Romero Gomez M, Oliveira C,
Day C, Dufour JF, Bellentani S, Ngo Y, Traussnig S, Perazzo H, Deckmyn O, Bedossa P, Ratziu V, Poynard T; FLIP Consortium and
the FibroFrance Group. Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as
histological reference. Aliment Pharmacol Ther. 2016 Oct;44(8):877-89.
2016-22. Nahon P, Nuraldeen R, Rufat P, Sutton A, Trautwein C, Strnad P. In alcoholic cirrhosis, low-serum hepcidin levels associate
with poor long-term survival. Liver Int. 2016 Feb;36(2):185-8.
2016-23. Nault JC, Nkontchou G, Nahon P, Grando V, Bourcier V, Barge S, Ziol M, Sellier N, Ganne-Carrie N, Seror O. Percutaneous
Treatment of Localized Infiltrative Hepatocellular Carcinoma Developing on Cirrhosis. Ann Surg Oncol. 2016 Jun;23(6):1906-15.
2016-24. Petsaris O, Vallet S, Le Guillou-Guillemette H, Veillon P, Gouriou S, Barbier G, Nousbaum JB, Saliou P, NKontchou G,
Trinchet JC, Lunel-Fabiani F, Payan C Duplication of the V3 domain in hepatitis C virus (1b) NS5A protein: Clonal analysis and
physicochemical properties related to hepatocellular carcinoma occurrence. J Clin Virol. 2016 Jan;74:19-25.
2016-25. Rekik S, Guyot E, Bhais M, Ajavon Y, Grando V, Bourcier V, Nkontchou G, Nahon P, Sellier N, Seror O, Ganne-Carrie N,
Nault JC. The CRP level and STATE score predict survival in cirrhotic patients with hepatocellular carcinoma treated by transarterial
embolization. Dig Liver Dis. 2016 Sep;48(9):1088-92.
2016-26. Seror O, N'Kontchou G, Nault JC, Rabahi Y, Nahon P, Ganne-Carrié N, Grando V, Zentar N, Beaugrand M, Trinchet JC,
Diallo A, Sellier N. Hepatocellular Carcinoma within Milan Criteria: No-Touch Multibipolar Radiofrequency Ablation for Treatment-
Long-term Results. Radiology. 2016 Sep;280(3):981.
2016-27. Tao J, Xu E, Zhao Y, Singh S, Li X, Couchy G, Chen X, Zucman-Rossi J, Chikina M, Monga SP. Modeling a Human HCC
Subset in Mice Through Co-Expression of Met and Point-Mutant β-Catenin. Hepatology, Nov;64(5):1587-1605, 2016
2015-1. Schulze K**, Imbeaud S**, Letouzé E**, Alexandrov LB, Calderaro J, Rebouissou S, Couchy G, Meiller C, Shinde J,
Soysouvanh F, Calatayud AL, Pinyol R, Pelletier L, Balabaud C, Laurent A, Blanc J-F, Mazzaferro V, Calvo C, Villanueva A, Nault
JC, Bioulac-Sage P, Stratton MR, Llovet JM, Zucman-Rossi J*. Exome sequencing of hepatocellular carcinomas identifies new
mutational signatures and potential therapeutic targets. Nature Genetics, 47(5):505-11, 2015. **equally contributed IF=27.9, Highly
Cited Paper
2015-2. !Benoit Beuselinck**, Sylvie Job**, Etienne Becht, Alexandra Karadimou, Virginie Verkarre, Gabrielle Couchy, Nicolas
Giraldo, Nathalie Rioux-Leclercq, Vincent Molinié, Mathilde Sibony, Reza Elaidi, Corinne Teghom, Jean-Jacques Patard, Arnaud
Méjean, Wolf Herman Fridman, Catherine Sautès-Fridman, Aurélien de Reyniès, Stéphane Oudard, Jessica Zucman-Rossi*. Molecular
subtypes of clear cell renal cell carcinoma are associated to sunitinib response in the metastatic setting. Clin Cancer Res, 21(6):1329-
39, 2015. **equally contributed IF=9.2
2015-3. Nault JC, Datta S, Imbeaud S, Franconi A, Mallet M, Couchy G, Letouzé E, Pilati C, Verret B, Blanc JF, Balabaud C, Calderaro
J, Laurent A, Letexier M, Bioulac-Sage P, Calvo F, Zucman-Rossi J Recurrent AAV2-related insertional mutagenesis in human
hepatocellular carcinomas, Nature Genetics, 47(10):1187-93, 2015 IF=27.9, Highly Cited Paper
2015-4. Louvet A, Labreuche J, Artru F, Boursier J, Kim DJ, O'Grady J, Trépo E, Nahon P, Ganne-Carrié N, Naveau S, Diaz E,
Gustot T, Lassailly G, Cannesson-Leroy A, Canva-Delcambre V, Dharancy S, Park SH, Moreno C, Morgan TR, Duhamel A, Mathurin
P. Combining Data From Liver Disease Scoring Systems Better Predicts Outcomes of Patients With Alcoholic Hepatitis.
Gastroenterology. 2015 Aug;149(2):398-406 2014 IF=18
2015-5. Trinchet JC, Bourcier V, Chaffaut C, Ait Ahmed M, Allam S, Marcellin P, Guyader D, Pol S, Larrey D, De Lédinghen V,
Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki JP, Zarski JP, Goria O, Calès P, Péron JM, Alric L, Bourlière M, Mathurin P,
Blanc JF, Abergel A, Serfaty L, Mallat A, Grangé JD, Buffet C, Bacq Y, Wartelle C, Dao T, Benhamou Y, Pilette C, Silvain C,
Christidis C, Capron D, Thiefin G, Hillaire S, Di Martino V, Nahon P, Chevret S; ANRS CO12 CirVir Group. Complications and
competing risks of death in compensated viral cirrhosis (ANRS CO12 CirVir prospective cohort). Hepatology. 2015 Sep;62(3):737-50.
IF=13.2
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