The Future of Genomic Medicine VII
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The FFuture
The uture ooff G
Thursday,
enomic M
Genomic edicine VIII
Medicine VII
Thu r s day, March
March 56 and Fr
Friday,
id a y, March 6, 2014
Ma rch 7, 2015 ••Sc
Scripps Seaside
r i p p s Se Forum
as i d e Fo r u m ••La
LaJoJolla,
l l a, CCalifornia
al i f o r n i a
Presented in partnership with
with
AAAS/Science Translational Mdicine
Medicine
Course Introduction Conference Highlights
• Voice of the patient represented
Course Overview throughout the conference
In collaboration with AAAS/Science Translational Medicine we invite you • Renowned faculty representing the
country’s leading institutions
to another exciting two day program on Thursday, March 5 and Friday,
• Multiple panel discussion segments
March 6, 2015 in beautiful San Diego, California. This year’s program will with ample question and answer time
with faculty
again be held at Scripps Seaside Forum.
• Additional networking opportunities
The 8th Future of Genomic Medicine conference will be the next iteration Educational Objectives
of taking genomic knowledge to transform the daily practice of medicine. After attending this activity, participants
should be able to:
To do this, we have patients present their story of how genomics affected • Demonstrate the unmet needs of
their medical status, and have an international faculty of experts in genom- medicine today with respect to more
targeted, individualized prevention
ics, science and medical journalism, and the life science industry provide and treatments.
critical perspective. This year we will be paying particular attention to the • Discuss the opportunities of the genome,
proteome, metabolome discovery to
exciting area of genomic editing to treat particular diseases, cancer (a dis- change medical practice as it exists today.
ease of the genome), and the genomics of rare and unknown diseases. Fur- • Assess how changes and advances in
technology are rapidly ushering in a whole
thermore, we will delve into to the hot topics of the microbiome, genom- array of new pathways for individualized
medicine of the future.
ic-guided drug therapies and genomic analytics. The overarching goal of
• Explore specific strategies in cancer,
the conference is to spearhead efforts to use genomic knowledge to change idiopathic and pharmacogenomic
futuristic interventions.
medicine and make it far more precise and individualized.
Target Audience
We look forward to your participation and another successful conference. • Physicians
• Human geneticists
• Genomic scientists
• Researchers
• Health care professionals of all
disciplines interested in the future
Eric J. Topol, MD of medicine, especially with respect
Course Director to individualized therapies
Disclosures and About Scripps
Disclosure
Commercial Support
This course is supported, in part, by educational grants from monitoring of individual patients. In addition, it is the only member
industry. At the time of printing, a complete listing of commercial of the National Institutes of Health’s Clinical and Translational Science
supporters was not available. Appropriate acknowledgement will Award (CTSA) consortium that is not affiliated with a university.
be given to all supporters at the time of the educational activity. STSI hybridizes The Scripps Research Institute (TSRI)‘s consider-
Cultural and Linguistic Competency able biomedical science expertise with Scripps Health’s exceptional
This activity is in compliance with California Assembly Bill 1195 patient care and clinical research. As a translational bridge between
which requires that all CME activities comprising a patient care TSRI and Scripps Health, STSI fosters innovative programs and
element include curriculum addressing the topic of cultural and methodology, provides an optimal setting for training and education
linguistic competency. The intent of this bill is to ensure that health and accelerates the conduct of studies that will have the greatest
care professionals are able to meet the cultural and linguistic potential impact on the practice of health care in the clinic and the
concerns of a diverse patient population through effective and community.
appropriate professional development. Cultural and linguistic For more information on the Scripps Translational Science Institute,
competency was incorporated into the planning of this activity. visit www.stsiweb.org.
About Scripps Scripps Health, a nonprofit health care system based in San Diego,
The Scripps Translational Science Institute (STSI) aims to replace California, includes more than 2,600 affiliated physicians and over
the status-quo of one-size-fits-all-medicine with individualized 13,000 employees at five acute-care hospital campuses, home
health care that is based on the known genetic factors influencing health care services and a network of clinics, physician offices and
health and disease and that takes advantage of advances in digital outpatient centers. Scripps is committed to contributing to the
technology for real-time health monitoring. future of medicine through its clinical research trials, graduate
Since its founding in 2006 by Scripps Health, STSI has been medical education and continuing medical education programs.
distinguished by its leadership in translational genomics and More information can be found at www.scripps.org.
for harnessing digital, or wireless, medical technology for health
Faculty
Course Director
Eric J. Topol, MD Atul Butte, MD, PhD Nazneen Rahman, MD, PhD
Director Chief and Associate Professor of Doctor and Geneticist
Scripps Translational Science Institute Systems Medicine
Chief Academic Officer, Scripps Health Department of Pediatrics Eric E. Schadt, PhD
Chairman and Professor
Professor of Genomics Stanford School of Medicine
Department of Genetics and
The Scripps Research Institute Stanford, California Genomic Sciences
La Jolla, California Director, Icahn Institute for Genomics
Francis S. Collins, MD, PhD
and Multiscale Biology
Director
Planning Committee National Institutes of Health
Icahn School of Medicine at Mount Sinai
New York, New York
Laura Nicholson, MD, PhD Bethesda, Maryland
Scripps Green Hospital Medicine Division Randy Scott, PhD
Jonathan Eisen, PhD Chairman and Chief Executive Officer
Associate Program Director
Professor InVitae™ Corporation
Medicine Residency
UC Davis Genome Center San Francisco, California
Internal Medicine Resident Research
Department of Evolution and Ecology
Director, Associate Clinical Professor
Department of Microbiology Andrew Su, PhD
UCSD Volunteer Faculty
and Immunology Associate Professor
La Jolla, California
University of California The Scripps Research Institute
Steven R. Steinhubl, MD Davis, California La Jolla, California
Director of Digital Medicine
Katherine A. High, MD Cristian Tomasetti
Scripps Translational Science Institute
La Jolla, California Investigator Assistant Professor
Howard Hughes Medical Institute Division of Biostatistics and Bioinformatics,
Ali Torkamani, PhD William H. Bennett Department of Oncology
Director of Genome Informatics and Professor of Pediatrics Sidney Kimmel Comprehensive
Drug Discovery Perelman School of Medicine at Cancer Center
Scripps Translational Science Institute the University of Pennsylvania, Center for Johns Hopkins University
Assistant Professor of Molecular and Cellular and Molecular Therapeutics at The School of Medicine
Experimental Medicine Children’s Hospital of Philadelphia
The Scripps Research Institute Baltimore, Maryland
Philadelphia, Pennsylvania
La Jolla, California Fyodor D. Urnov, PhD
Virginia Hughes Senior Scientist
Nathan E. Wineinger, PhD Science Journalist
Assistant Professor Project and Team Leader
Director of Biostatistics Sangamo BioSciences, Inc.
J. Keith Joung, MD, PhD
Scripps Translational Science Institute Associate Chief of Pathology for Research Elizabeth A. Worthey, PhD
La Jolla, California Associate Professor of Pathology Assistant Professor
Massachusetts General Hospital Department of Pediatrics
Faculty Charlestown, Massachusetts Faculty Member
Children’s Research Institute
Christopher P. Austin, MD Mark McCarthy Director of Genomic Informatics
Director Robert Turner Professor of Diabetes Human and Molecular Genetics Center
National Center for University of Oxford Adjunct Assistant Professor of
Advancing Translational Sciences Oxford Centre for Diabetes, Endocrinology Clinical Informatics
National Institutes of Health & Metabolism & Wellcome Trust Centre for Medical College of Wisconsin
Bethesda, Maryland Human Genetics Milwaukee, Wisconsin
Kristin Baldwin, PhD Evan D. Muse, MD, PhD George D. Yancopoulos, MD, PhD
Associate Professor Cardiologist President, Research Laboratories
Investigator, Dorris Neuroscience Center Scripps Health Chief Scientific Officer
Department of Molecular and Regeneron Pharmaceuticals, Inc.
Cellular Neuroscience La Jolla, California
The Scripps Research Institute Tarrytown, New York
Seth Mnookin
La Jolla, California Associate Director Roni Zeiger, MD
The Graduate Program in Chief Executive Officer
Diana W. Bianchi, MD
Executive Director Science Writing, M.I.T. Smart Patients
Mother Infant Research Institute Author and Journalist
Vice Chair for Research and
Svante Pääbo, PhD
Academic Affairs
Author, Neaderthal Man
Department of Pediatrics
Director, Department of Genetics
Attending Geneticist and Neonatologist
Max Planck Institute for
Natalie V. Zucker Professor
Evolutionary Anthropology
Tufts University School of Medicine
Leipzig, Germany
Boston, Massachusetts
Joe Pickrell, PhD
Martin J. Blaser, MD Junior Investigator and Core Member
George and Muriel Singer New York Genome Center
Professor of Medicine Adjunct Professor
Professor of Microbiology Department of Biological Sciences
Director, Human Microbiome Program at Columbia University
New York University Langone
Medical Center New York, New York
New York, New York Stephen Quake, DPhil
Professor of Bioengineering
Co–Chair, Department of Bioengineering
Investigator
Howard Hughes Medical Institute
Stanford, California
Agenda
Thursday, March 05, 2015 Afternoon Session I:
7:30 a.m. Registration and Breakfast Genomic – Guided Drug Therapy
1:20 p.m. Genomic-Guided Intervention for Diabetes
8:00 a.m. Welcome and Opening Remarks
Mark McCarthy
Eric J. Topol, MD
1:40 p.m. Rare Diseases and Root Cause Mutations
8:15 a.m. Patient # 1: Incidental detection of cancer
Christopher P. Austin, MD
with a non-invasive prenatal test (NIPT)
Eunice Lee, MD and Nilesh Dharajiya, MD 2:00 p.m. Discovery
George D. Yancopoulos, MD, PhD
8:55 a.m. State of the Field
Francis S. Collins, MD, PhD 2:20 p.m. Afternoon Session I Panel Discussion/Q&A
Afternoon Session I Speakers and Moderators
Morning Session I:
2:50 p.m. Break, View Exhibits and Networking
Lessons from Neanderthals for Medicine’s Future
9:55 a.m. The Genetic Contribution of Neanderthals Afternoon Session II: Genome Analytics
Svante Pääbo, PhD
3:20 p.m. Translating Trillions of Points of Data
10:15 a.m. Break, View Exhibits and Networking Atul Butte, MD, PhD
3:40 p.m. The Network Organized Wisdom Of Crowds
Morning Session II: Cell Free DNA and RNA
Eric E. Schadt, PhD
10:45 a.m. Cancer
4:00 p.m. Using Citizen Science to Organize
TBD
Biomedical Knowledge
11:05 a.m. Prenatal DNA Sequencing Andrew Su, PhD
Diana W. Bianchi, MD
4:20 p.m. Large-Scale Human Genomics
11:25 a.m. Endothelial Joe Pickrell, PhD
Evan D. Muse, MD, PhD
4:40 p.m. Afternoon Session II Panel Discussion/Q&A
11:45 a.m. Molecular Stethoscope Afternoon Session II Speakers and Moderators
Stephen Quake, DPhil
5:10 p.m. Adjourn
12:05 p.m. Morning Session II Panel Discussion/Q&A
Morning Session II Speakers and Moderators Thursday Evening Welcome Reception at
12:35 p.m. Lunch, View Exhibits and Networking Scripps Seaside Forum
Location: 8610 Kennel Way
La Jolla, California 92037
Reception will take place following the conclusion of the
conference until 7:30 p.m.
Friday, March 06, 2015 Afternoon Session I: The Microbiome
7:30 a.m. Registration and Breakfast 1:40 p.m. Early Life as the Crucible for Microbiome
Martin J. Blaser, MD
8:00 a.m. Patient # 2
2:00 p.m. The Evolution and Ecology of Microbiomes
Morning Session I: Jonathan Eisen, PhD
Cancer Genomic Medicine – The BIG Picture
2:20 p.m. Mobile Genomic Medicine
8:40 a.m. TBD Steven R. Steinhubl, MD
Cristian Tomasetti
2:40 p.m. Break, View Exhibits and Networking
9:25 a.m. Implementing High-Throughput, Large-Scale
Testing of Cancer Predisposition Genes Afternoon Session II: Rare and Unknown Diseases
Nazneen Rahman, FMedSci
2:50 p.m. Complexities in Clinical Interpreting of
9:45 a.m. Making Multi-Gene Testing for Genome Wide Sequencing Data
Hereditary Cancer Elizabeth A. Worthey, PhD
Randy Scott, PhD
3:10 p.m. Update: The Scripps IDIOM Project
10:05 a.m. Advancing Personalized Cancer Therapy Ali Torkamani, PhD
Roni Zeiger, MD
3:30 p.m. Silos and Sequencing
10:25 a.m. Morning Session I Panel Discussion/Q&A Seth Mnookin
Morning Session I Speakers and Moderators
3:50 p.m. When Genes are Beside the Point:
10:45 a.m. Break, View Exhibits and Networking Two stories
Virginia Hughes
Morning Session II: Genome Editing
4:10 p.m. Afternoon Session II Panel Discussion/Q&A
11:15 a.m. Overview
Afternoon Session II Speakers and Moderators
J. Keith Joung, MD, PhD
4:40 p.m. Closing remarks and Adjourn
11:35 a.m. Clinical Application of Genome Editing
Fyodor D. Urnov, PhD
Friday Evening Closing Reception at
11:55 a.m. Hemophilia Scripps Seaside Forum
Katherine A. High, MD
Location: 8610 Kennel Way
12:15 p.m. Cardiovascular La Jolla, California 92037
Kristin Baldwin, PhD
Reception will take place following the conclusion of the
12:35 p.m. Morning Session II Panel Discussion/Q&A conference until 7:30 p.m.
Morning Session II Speakers and Moderators
12:55 p.m. Lunch, View Exhibits and NetworkingConference Location & Hotel Information
Scripps Seaside Forum Recommended Lodging
Estancia La Jolla Hotel & Spa
Scripps institution of
9700 N. Torrey Pines Road
La Jolla, California 92037
oceanography UC San Diegoo
Located only one mile from the conference venue, this
beautiful hotel is situated adjacent to the Salk Institute for
Robert Paine Scripps Forum for Science, Society Biological Studies, the University of California San Diego
and the Environment (UCSD), the village of La Jolla, beaches, shopping, and San
Samuel H. Scripps Auditorium Diego’s world-class attractions.
8610 Kennel Way , La Jolla, California 92037 Make your reservations early! A specially priced block of
rooms is being held until Tuesday, February 17, 2015. After
that time, reservations will be accepted on a space and rate
availability basis only. Be sure to request the Scripps reduced
rate of $199 per night plus tax. This low rate also includes:
• Discounted valet parking at $10 for overnight & day
• Complimentary guestroom internet service
• 10% Spa Discount, Monday – Friday
for conference attendees
• Discounted Hospitality Services Fee of $10
Reservations:
Online: www.estancialajolla.com (Enter code: FoGMVIII
when making your reservation online in order to receive the
reduced rate)
Phone: (877) 437-8262 (Reference “Scripps Genomic
Medicine Conference” when making your reservation in
order to receive the reduced rate.)
La Jolla Shores Hotel
8110 Camino Del Oro
Depicts approx. a 2 mile radius.
La Jolla, California 92037
Directions Located only steps from the conference venue, La Jolla
Shores Hotel is one of the select few hotels in San Diego
• From Interstate 5, head west on La Jolla Village Drive situated directly on the beach.
towards Birch Aquarium
• Make a left on Expedition Way Make your reservations early! A specially priced block of
rooms is being held until Thursday, February 19, 2015. After
• Make a right on Downwind Way at the stop sign before
that time, reservations will be accepted on a space and rate
Birch Aquarium
availability basis only. Be sure to request the Scripps reduced
• This road curves to the left. Follow it to the end rate of $180 per night plus tax for the Garden View Hotel
• Make a left on La Jolla Shores Drive room, $185 per night plus tax for the Coast View room or
• Make a right on El Paseo Grande $195 per night plus tax for the Beach Front room. This low
• Scripps Seaside Forum will be on your right rate also includes:
• Discounted parking: $5/day and $14/ overnight
Parking and Transportation: • Complimentary guestroom internet service
• IMPORTANT! You CAN NOT park in the lots outside of Reservations:
Scripps Seaside Forum. You will be ticketed.
Online: www.ljshoreshotel.com (Enter group code: FOGMVIII
• Directional parking signs will be displayed and additional when you “click here for special rates.”)
information regarding available parking will be provided
upon registration. Phone: (866) 392-8762 (Reference “Scripps Genomic
Medicine Conference” when making your reservation in
• Parking is available in the underground parking lot at La
order to receive the reduced rate)
Jolla Shores Hotel ($10/vehicle) and at Kellogg Park (free).
Please see the front desk at the hotel and mention you are Please note: Attendees who book their room through an
attending the Scripps Genomic Medicine Conference in online, third-party service (Hotels.com©, Expedia.com©,
order to obtain a parking pass to receive the discounted rate. Priceline.com©, etc.) are not eligible to receive the amenities
• Street parking is also available. listed above.
• There will be a looping shuttle on Thursday, March 5 and
Friday, March 6 between Scripps Translational Science DOWNLOAD THE SCRIPPS CME APP FOR YOUR SMART PHONE OR TABLET!
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to park in a UCSD parking lot and take the SIO shuttle browser: www.grupio.com/ScrippsCME
to/from Scripps Seaside Forum.The Future of Genomic Medicine VIII WAYS TO REGISTER
Online: www.Scripps.org/GenomicMedicineConf
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Please note, this course does not offer Continuing Medical Education (CME) credits. Fax: (858) 652-5565
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11025 NorthTorrey
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Jolla,California
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The FFuture
The uture ooff Genomic M
Genomic edicine VIII
Medicine VII
Thursday, March
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Friday,March
March 6,
7, 2015
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Conference Highlights
Conference
• Two-day Highlights
curriculum
• Renowned faculty representing the country’s leading
• Voice of the patient represented throughout
institutions, chosen for their expertise as well as teaching skills
the conference
• Multiple panel discussion segments with ample
question and answerfaculty
• Renowned time with faculty
representing the country’s
• Additional networking opportunities
leading institutions
The FFuture
The uture ooff Genomic M
Genomic edicine VIII
Medicine VII • Multiple panel discussion segments with ample
T h u r sThursday,
d a y, M a March
r c h 6 5a and
n d Friday, March
F r i d a y, M a r6,c h2015
7, 2014 What attendees hadand
to say!
question answer time with faculty
S c r i p pScripps
s S e a sSeaside
i d e F oForum
r u m • La
L aJolla,
J o l lCalifornia
a, California • One of the best conferences in this field I have ever attended!
• Additional
World networking
class speakers, science and opportunities
passion.
• Anyone who is involved in medicine and/or genomics research
should attend get a picture of where science and medicine
are heading.
• I was so impressed with the prestige of the speakers and the
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w w w. f a c e b o o k . c o m / S c r i p p s C M E
w w w. y o u t u b e . c o m / s c r i p p s h e a l t h
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