Rheumatology - Author: Jack March - Rheumatology.Physio - Clinical Scenarios For MSK Therapists
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Rheumatology Clinical Scenarios For MSK Therapists Including: Spondyloarthritis Rheumatoid Arthritis Osteoporosis Systemic Lupus Erythematosus And MORE… Author: Jack March – Rheumatology.Physio 1
Throughout my Preface career as a These case studies are based on real Physiotherapist I have seen a lot of patients that I have adapted to fit the patients. A significant number of these style of the book and to make useful have been either in a Rheumatology learning tools. department or as what we would now call a First Contact Practitioner. You will likely notice that there are a lot of grey areas. You may even suspect other I have always been one to write case diagnoses to be a likely cause of the studies and as a result I have a large symptoms presenting, and this good. number stored. I wrote up cases that I Embrace those thought patterns. I am found interesting, unusual or sometimes most certainly not always right. even “typical” in varying degrees of detail. I hope you find this book useful in In recent years I have been fortunate practice, and makes you think about enough to have gained a little reputation certain patients who at first glance might as someone to ask regarding topics and not be obvious to you. cases in Rheumatology, and I see various themes repeat themselves. Enjoy! Jack. As a result, I decided to adapt some of my case studies into this book. I hope that it helps to add some context to the information I write in my blogs and teach on my courses.
About the Author Jack March Rheumatology.Physio Jack is a Physiotherapist, qualified in 2008 from Plymouth University and after rotational posts settled into Rheumatology which I have made my specialty since 2011. I have given seminars, lectures at conferences and full day courses on Rheumatology subjects mostly covering the topics of Recognition, Investigation and Management. These have been aimed at Allied Health Professionals (Physios, OTs, Nurses…) but have also been attended by Medical Colleagues from GP practices who have also provided positive feedback. My current roles alongside the provision of CPD include: Rheumatology Clinical Lead for Chews Health. Operations Director of The Physio Matters Podcast and Chews Media. @Physiojack @rheumatology.physio 2
Contents Introduction Page 6 01 Spondyloarthritis Page 8 02 Rheumatoid Arthritis Page 17 03 Osteoporosis Page 24 04 Gout Page 29 05 Systemic Lupus Page 34 Erythematosus 06 Sjogren’s Page 38 Syndrome 07 Polymyalgia Rheumatica Page 41 08 Reactive Arthritis Page 44 09 Self Assessment Page 51 10 Referral Letters Page 54
Introduction Hello! Thank You for deciding to spend This also applies to Therapists who are some time with this book. It is designed to seeing patients following Medical help you think about the complexity and screening. Don’t assume it has been clinical reasoning process surrounding thorough. Do your own comprehensive Rheumatological conditions. assessments and make your own clinical judgments. The aim of this book is to help This book is aimed at clinicians who are you with just that. seeing patients prior to any medical screening e.g. First Contact Practitioners For many reasons, one being brevity, I (FCPs) or those in Private Practice. We have “stayed in my lane” with this book. must make sure we are detailed in our As you work through the case studies you assessments, consider all possible causes will notice the absence of red flag for the attending person’s symptoms, and screening, neurological symptoms and make sure that we know what to do with other areas of questioning. This keeps the that information. length of the cases palatable, and stopped the book from taking me years to This book hopes to fill a gap in the write. reasoning process for clinicians - Rheumatology, a complex, difficult and I am trusting you to know other screening sometimes intimidating set of conditions. requirements of back pain, multiple joint Unfortunately, delay to diagnosis in this pain and systemically unwell people. I cohort can have dire consequences, and hope you will repay me with some leeway as such we cannot afford to be when it comes to omitting information complacent. about radicular pain, bladder and bowel function and so forth. Poor outcomes across the board occur in Rheumatology when diagnoses are missed The assessment sections of this book and patients have to wait to see a really are what you make them. You could specialist. jump ahead to learn what I think the answer is, but I personally think that you As Therapists we can no longer hide will be missing a trick. I truly believe behind prior medical screening or claims immersing yourself in these simulated of ignorance as we move closer and closer scenarios will help you in the real world. to the start of patient’s journeys. We must take responsibility and ensure that we are the best clinicians we can be for the patients attending our clinics. 4
Introduction Before there is the chance for me to make I will stop now and let you get on to the this introduction longer than the book reason you started looking at this book. itself, I have one final thought. I hope I will get to meet you some time You will see that I have hinted at what we via social media or at an in-person event should do in certain scenarios. As we are of some kind. suspecting “medical” issues in these patients we are inevitably referring them Now pop your thinking hat on and away out of Therapy. Consider what other value you go! you can add during their appointment. Let’s not rest on our smugness of successfully identifying a relatively rare condition and bounce them straight on to the appropriate location. Let’s instead think, “how can I improve their outcome?”. Really simple interventions and advice can make a big difference. I know time and resources are limited, but spending just a little of it on reassurance, education and guidance could make the world of difference in the long term. This book does not have all the answers. I make some assumptive leaps of prior knowledge. Feel free to use a search engine or get in contact with me for clarification. Use my other CPD materials (most of which are free because I am terrible at business) to help you along the way as well. To help me, please do get in touch with feedback and if you think it’s great, tell your colleagues about it! 5
1 Spondyloarthritis Spondyloarthritis (SpA) is an umbrella term covering auto- immune conditions affecting the Axial skeleton (the spine and sacroiliac joints) and/or the peripheral entheses (achilles, plantar fascia, lateral epicondyle insertions). Conditions falling under this umbrella include Axial Spondyloarthritis and Psoriatic Arthritis. There are familial connections with the conditions and there is a strong association with 85-95% HLA- B27 positivity. 6
Spondyloarthritis Scenario 1 Referral Aggravating/Easing John is a 25 year old male complaining of Sitting for extended periods at his desk, thoracic back pain lasting for 3 months. driving or watching TV aggravates his back No previous past medical history or pain. Nothing aggravates the buttock attendance to MSK Therapists. No pains which are present when he wakes in regularly prescribed medications. the morning and resolve over the period of an hour. Ibuprofen eases his symptoms Further Subjective Information and he takes this regularly through the Insidious onset thoracic back pain 3 day. Going to the gym does not aggravate months ago with bilateral buttock pain symptoms and he is possibly worse on most days. No previous back pain, no days he doesn’t go. previous injuries or musculoskeletal Past Medical History complaints. No change in habits, occupation or circumstances prior to He has no known health issues. He has onset. Has not been unwell or required not attended his GP in the last 5 years. He antibiotics. does not take any prescribed medications. He denies any sexually transmitted 24 hour pattern infections and use of steroids. He feels Feels extremely stiff when he wakes in well in himself but slightly fatigued due to the morning with significant back pain. interrupted sleep. He denies feeling This lasts for approximately 1 hour. The anxious or depressed. pain and stiffness will return after sitting He has no personal or family history of at his work desk for longer than 1 hour psoriasis, iritis/uveitis, crohns/colitis or and requires walking around to resolve. inflammatory arthropathies He has no issues during the day if he is not at work because he can keep moving. Social Factors He is able to fall asleep but wakes around He works at a desk writing software. He 2am every morning with pain and enjoys going to the gym and has a well stiffness. After getting out of bed and rounded program. He doesn’t smoke, doing some stretches he is able to go back drinks occasional alcohol and has a BMI of to sleep. 24. He believes his pain is likely down to his posture at work. Clinical Reasoning Activity From the case presentation note down the indicators that John could have AxSpA 7
Spondyloarthritis Scenario 1 John is presenting as a classical new Reassure John that the prognosis for onset Axial Spondyloarthritis these conditions is good when diagnosed and managed early. He already lives a - Insidious onset back pain and buttock healthy lifestyle and he should continue pain for 3 months this as much as possible to improve his - Pain and stiffness in the morning for chances of a good outcome. Consider >60 mins specific therapy management if there are - Worse with rest, better with activity reported functional deficits. - Waking in the second half of the night, getting out of bed to ease Investigations symptoms If appropriate and available refer for: - Eased by NSAIDs - Spondyloarthritis protocol MRI of Next Steps whole spine and Sacroiliac Joints Explain to John that the clinical picture is - Blood tests: HLA-B27, ESR, CRP one suspicious of an inflammatory cause Onwards Referral of his symptoms, which needs referring to a Rheumatologist for further Refer to Rheumatology via the investigations. The aim of this appropriate local pathway for further appointment is to confirm or rule out a investigation of symptoms suspicious of specific diagnosis and start appropriate Axial Spondyloarthritis. treatment if necessary. Learning Points. Symptom pattern alongside aggravating Reassurance and general health advice at and easing factors are key to recognition this early stage are important in John’s case accompaniments to the prompt referral AxSpA should be considered in the differential diagnosis for younger persons (3 months 8
Spondyloarthritis Scenario 2 Referral 24 hour pattern Jane is a 35 year old female complaining Severe pain in the mornings when she of insidious onset bilateral heel pain for gets out of bed which takes 2 hours to the last 6 weeks. She takes no regular improve. This will return to a lesser medication. She has a past medical degree during the day after sitting or after history of Psoriasis which is managed by walking for longer periods. Her sleep is moisturisers. She attended a unaffected. Physiotherapist last year for repetitive Aggravating/Easing strain in her hand. Her heel pain is worse after sitting / Further Subjective Information driving for any period of time. This will Insidious onset bilateral heel pain 6 weeks resolve over a period of time relative to ago. She awoke one morning and was how long she was sat, from a few minutes unable to weight bear through her heels. to a few hours. This improved after a few minutes and Past Medical History she ignored it. This has gradually worsened over the last 6 weeks and now She has no known health issues other she struggles to walk for the first 2 hours than the Psoriasis. She attended her GP in the morning. No change in habits, for the hand symptoms last year and prior occupation or circumstances prior to to this the tennis elbow. She does not onset. Has not been unwell or required take any prescribed medications. She antibiotics. denies any sexually transmitted infections and use of steroids. She feels well in She has had psoriasis for 10 years and herself and denies feeling anxious or manages this with moisturiser. Last year depressed but feels fatigued constantly. she developed pain and swelling in the IPJs of her index and middle finger in the She has no personal or family history of right hand, this was diagnosed as a iritis/uveitis or crohns/colitis. Her father repetitive strain issue. Improved with has Psoriatic Arthritis. She has no nail bed physiotherapy and ergonomics over a few changes. months and then resolved after 6 months. She had Lateral Epicondylopathy 5 years ago which lasted 2 years and was quite debilitating. 9
Spondyloarthritis Scenario 2 Social Factors She has been concerned about Psoriatic She works at a desk as an estate agent Arthritis since she developed the hand and often drives to view houses. She symptoms but was reassured as they enjoys walking her dog 3-4 miles a day, went away. this is not normally an issue. She smokes 10/day and has a BMI of 32. Clinical Reasoning Activity From the case presentation note down the indicators that Jane could have SpA Jane is presenting with a possible Discuss with Jane her general health as Peripheral Spondyloarthritis; likely her high BMI and smoking status will Psoriatic Arthritis. contribute to a raised level of systemic inflammation. This may increase the - Insidious onset bilateral tendinopathy likelihood of developing Psoriatic Arthritis (plantarfasciitis) or the separate clinical conditions. If - Symptoms in the morning for >60 diagnosed with Psoriatic Arthritis, these mins factors will also make a poorer outcome - Previous Lateral Epicondylopathy and more likely. Consider starting specific previous IPJ swelling and pain therapy management for the bilateral - Diagnosed Psoriasis heel pain to plan for the possibility - Father has Psoriatic Arthritis Psoriatic Arthritis is ruled out. - High BMI and Smoker A trial of anti-inflammatories may be Next Steps worthwhile to assess impact on Explain to Jane that the clinical picture is symptoms. one suspicious of an inflammatory cause Investigations of her symptoms which needs referring to a Rheumatologist for further If appropriate and available refer for: investigations. The aim of this - Ultrasound imaging to look for appointment is to confirm or rule out a Insertional Enthesitis specific diagnosis and start appropriate - Blood tests: HLA-B27, ESR, CRP, treatment if necessary. Rheumatoid Factor 10
Spondyloarthritis Scenario 2 Onwards Referral Refer to Rheumatology via the appropriate local pathway for further investigation of symptoms suspicious of Peripheral Spondyloarthritis (pSpA). Learning Points. pSpA should be considered in the Family History of inflammatory conditions presence of Psoriasis and Tendinopathy adds a strong clinical suspicion and even if one or both are historical reduces threshold for referral General health advice at this early stage In this scenario it is possible that Jane has is important accompaniments to the multiple distinct clinical conditions, it is prompt referral for short and long term not possible to rule out pSpA and as such outcomes regardless of the final warrants referral for specialist diagnosis investigation 11
Spondyloarthritis Scenario 3 Referral He has never had any radicular pain or Adam is a 45 year old male complaining of neurological-sounding symptoms. low back pain lasting for 3 years. He has His back pain is activity dependent - the Ulcerative Colitis and takes Azathioprine busier he is at work the worse it gets. If he to manage this. is resting or on holiday it is much better. Further Subjective Information He started parkrun to improve his fitness last year. His back will ache during and 3 years ago Adam was lifting crates at after but no worse than any other day. work. The next day he had a stiff back which worsened over a few days and He sometimes struggles to get to sleep at became quite painful. He was off work for night because he feels his back is a month at the time. It improved enough uncomfortable. He doesn’t wake during that he was able to return. He has had the night. He thinks his back is stiff for a varying degrees of low back pain since few minutes in the morning but certainly and seen a physiotherapist, an osteopath not for a protracted period of time. and a chiropractor which have settled the Aggravating/Easing symptoms in the short term. Although annoying, his back pain doesn’t bother Lifting at work aggravates his back pain. If him on a day to day basis. he has a large number of heavy things to lift his back pain will deteriorate during Recently however he has had a flare up of the day. He takes occasional paracetamol symptoms, and has been off work again to help. Usually if he aggravates his back for the last 2 weeks. He is unsure if there at work, he is ok the next day to work is a trigger for these flare ups. again. The only change to this is a flare up He recalls a number of previous aches and of more severe pain which happens like pains including achilles tendinopathy 2 clockwork every 6 months. years ago, bilateral epicondylopathy last year, and some lateral hip pain 5 years ago which lasted a year before settling with a steroid injection. Alongside various Xrays of his pelvis and lumbar spine he had an MRI of his lumbar spine 6 months ago which showed a small left sided disc bulge and a report of a degenerative disc. 12
Spondyloarthritis Scenario 3 Past Medical History Social Factors He has Ulcerative Colitis and has been He works as a delivery driver and this can under the Gastroenterology team for 20 vary in intensity, less intense days are years. This is stable and managed well better. He does parkrun once a week. He with Azothiaprine. He feels well in himself eats a healthy diet, does not smoke and except frustrated with his back. He denies has a BMI of 26. feeling anxious or depressed. He has no personal or family history of psoriasis, iritis/uveitis or inflammatory arthropathies Clinical Reasoning Activity From the case presentation note down the indicators that Adam could have AxSpA: Adam is presenting as a possible Axial He has had previous therapeutic input Spondyloarthritis (likely Enteropathic) which, while potentially settling the acute flare ups, has never managed the - Chronic back pain with insidious persistent back pain. Although he has had acute flare-ups previous imaging of his back, he has not - Ulcerative Colitis under had correct sequencing to determine if Gastroenterology radiological signs are present. - 4 previous tendon complaints A referral to Rheumatology for specialist Next Steps investigations to rule out Axial Explain to Adam that his symptoms may Spondyloarthritis as the cause of his back be explained and linked by an pain and previous tendon issues is inflammatory pathology. Although none appropriate. Beginning some therapeutic of his symptoms are truly inflammatory in management alongside the referral to nature (i.e. his back pain is not a classical Rheumatology to settle the flare up is also picture), the linking condition is the reasonable as this has been effective for Ulcerative Colitis. A high proportion of him in the past. people with this condition go on to develop an associated inflammatory arthropathy. 13
Spondyloarthritis Scenario 3 Investigations Onwards Referral If appropriate and available refer for: Refer to Rheumatology via the appropriate local pathway for further - Spondyloarthritis protocol MRI of investigation of symptoms suspicious of whole spine and Sacroiliac Joints Axial Spondyloarthritis. - Blood tests: HLA-B27, ESR, CRP Learning Points. Rheumatology referral is appropriate in Threshold Family Historyfor of referral in these types inflammatory of conditions this case despite the back pain not cases addsis alow. Thisclinical strong is appropriate, suspicionasand the being inflammatory in nature. It is incidence reduces of threshold SpA in Ulcerative Colitis for referral chronic and the associated Ulcerative patients is significant, as is the current Colitis is sufficient to meet a threshold delay to specialist referral and diagnosis. for referral. Offering therapy management for functional deficits and pain management is also appropriate during this flare up to get Adam back to work. If he was outside of a flare up then I would offer him the choice to undertake another episode of therapy if he thought it would be helpful. 14
2 Rheumatoid Arthritis Rheumatoid Arthritis is an inflammatory polyarthropathy characterised by acute synovitis, most commonly in the MCPJs and MTPJs, although any synovial joint can be affected. The persistent synovitis leads to an excess of inflammatory infiltrate in the joint which left untreated causes irreversible erosions. In the long term other body systems can become affected and there is an increased risk of clinically important conditions such as Cardiovascular Disease and Osteoporosis. 15
Rheumatoid Arthritis Scenario 1 Referral Aggravating/Easing Mary is a 20 year old female complaining Any form of activity with her hands of bilateral hand pain and swelling over aggravates the pain. The stiffness is worse the Metacarpal Phalangeal Joints (MTPJs) following any period of rest and then for the last 2 weeks. She takes no frees up with activity, although that is also prescribed medications. painful. Activity seems to aggravate the swelling, redness and warmth of the Further Subjective Information MTPJs. Insidious onset bilateral hand swelling and Past Medical History pain of the MCPJs for the last 2 weeks. She is struggling with all functional tasks She has no known health issues and does as she has decreased range of motion in not take any prescribed medications. She both hands, the joints are very stiff to denies any sexually transmitted infections move and it is painful to grip anything. and use of steroids. She feels well in There is a constant swelling and the joints herself but feels very fatigued which she can also be warm and red at times. She puts down to a lack of sleep. She feels a has also noticed she is very tired all the little anxious about her symptoms as they time since the symptoms began. She is are so restrictive. She denies feeling having to take paracetamol and ibuprofen depressed. to take the edge off the pain. She has She has no personal or family history of been off work since the onset of the psoriasis, iritis/uveitis, crohns/colitis or symptoms. inflammatory arthropathies. She has not 24 hour pattern had any previous joint or soft tissue problems or injuries. She has a positive Her hand joints are stiff all day without MCPJ squeeze test bilaterally and a resolution. The pain is worst in the positive MTPJ squeeze test on the right mornings and eases very slightly around foot. lunchtime. She struggles to get to sleep at night because of the pain and then is Social Factors awoken regularly as well. Bathing her She works as a designer which requires hands in warm water and doing some some computer work and some artwork. gentle movements can free up her hands She has been off work for the duration of a little in the morning. the symptoms. She normally attends the gym regularly to keep fit. She doesn’t smoke, doesn’t drink alcohol and has a BMI of 22. 16
Rheumatoid Arthritis Scenario 1 Clinical Reasoning Activity From the case presentation note down the indicators that Mary could have Rheumatoid Arthritis: Mary is presenting as a classical new Investigations onset Rheumatoid Arthritis (RA) If appropriate and available refer for: - Insidious acute onset bilateral MCPJs - Ultrasound scanning of the MCPJs swelling, stiffness, redness, heat and and MTPJs looking for synovitis pain - Blood tests: Anti-CCP, ESR, CRP, - Pain and joint stiffness all day Rheumatoid Factor - Waking in the night with pain and joint stiffness Onwards Referral - Stiffness reduces with activity Refer to Rheumatology via an Early - Female Inflammatory Arthritis Pathway if - MCPJ and MTPJ squeeze tests available locally. positive Next Steps Explain to Mary that her symptoms are suggestive of Rheumatoid Arthritis, which warrants a referral to Rheumatology for specialist investigation and instigation of appropriate medical management. Reassure Mary that prognosis is good for Rheumatoid Arthritis when diagnosed and managed early, and that as many as 50% of people are in clinical remission at 1 year following diagnosis. Her good general health make this a more likely outcome. Consider specific therapy management by a hand specialist for her reported functional deficits. 17
Rheumatoid Arthritis Scenario 1 Learning Points. Insidious onset bilateral symptoms in the In Mary’s case symptoms are clearly peripheral joints are suspicious of inflammatory in nature (swelling, redness, inflammatory arthritis in a younger heat, protracted joint stiffness) person Onwards referral to Rheumatology by a Reassurance and general health advice at quick access pathway is the priority this early stage are important action accompaniments to the prompt referral 18
Rheumatoid Arthritis Scenario 2 Referral These symptoms will return if he spends a significant period of time sitting or Andrew is a 60 year old male complaining driving. He manages walking without too of right knee pain and swelling lasting 3 much trouble, except after periods of months. He has no other medical rest. conditions and takes no prescribed medications. He does occasionally wake at night with his knee aching, usually in the early hours Further Subjective Information of the morning. This is reduced if he takes Andrew reports his right knee swelled up ibuprofen before bed. after being on holiday. He had done a lot Aggravating/Easing of walking and his knee had been sore towards the end of the day. When he got Periods of keeping the knee still aggravate back it remained sore and swelled quite the knee stiffness and pain when he goes significantly. It was occasionally warm to to move again. Stairs are difficult in the the touch but not red. He finds it stiff at morning, but otherwise the knee is times but this eases with movement. tolerable. Ibuprofen helps ease the symptoms. He is struggling functionally with the stairs, especially in the morning. If he has Past Medical History been sat in the car for a protracted period He is generally fit and well and does not he finds walking difficult until the stiffness take any prescribed medications. He eases. Andrew thinks he has arthritis now denies any sexually transmitted infections because he had a number of football knee and use of steroids. He feels well in injuries when he was younger including a himself, not fatigued, and denies anxiety couple of meniscal surgeries. or depression. He has no other joint pains, has not been He has no personal or family history of unwell or required to visit his GP or MSK psoriasis, iritis/uveitis, crohns/colitis. His therapist over the last 5 years. He is Grandmother and his Sister have finding ibuprofen helpful. Rheumatoid Arthritis. 24 hour pattern Social Factors His knee is stiff and painful in the He is a retired police officer and enjoys mornings for approximately 30 minutes. gardening, reading and movies. He smokes 15/day, drinks alcohol most days and has a BMI of 32. 19
Rheumatoid Arthritis Scenario 2 Clinical Reasoning Activity From the case presentation note down the indicators that Andrew could have Rheumatoid Arthritis: Andrew is presenting as a possible new Depending on Andrew’s preference, onset Rheumatoid Arthritis (RA) commencing a graded exercise program for his knee will be beneficial regardless - Insidious onset (no overt injury) right of diagnosis. knee pain with swelling and stiffness - Pain and swelling in the morning Investigations lasting 30 minutes If appropriate and available refer for: - Waking in the night with pain and joint stiffness - MRI most likely to be useful in this - Worse with rest case to assess joint and synovium - Improvement with NSAIDs - Blood tests: Anti-CCP, ESR, CRP, - Strong family history Rheumatoid Factor Next Steps Onwards Referral Explain to Andrew that his symptoms Refer to Rheumatology via an Early indicate the possibility of RA, which Inflammatory Arthritis Pathway if warrants a referral to Rheumatology for available locally. specialist investigation and instigation of appropriate medical management. Discuss with Andrew that his symptoms could be due to Osteoarthritis but due to his strong family history of RA it is necessary to rule this out as a cause. Regardless of the end result a reduction in his BMI, smoking and alcohol intake will significantly improve the likelihood of a positive outcome for him. Consider concurrent referrals to appropriate services to facilitate this. 20
Rheumatoid Arthritis Scenario 2 Learning Points. Andrew’s symptoms are arguably His lifestyle factors may have a significant consistent with Osteoarthritis but the impact on his systemic inflammation, strong family history in the presence of contributing to the inflammatory picture even mild inflammation justifies that he presents with. Rheumatology referral Interventions instigated at this stage e.g. weight loss, smoking cessation, graded Peak onset for RA is 40-60 so he is exercise program, have a good chance of within this range being effective regardless of the outcome 21
3 Osteoporosis Osteoporosis is a combination of reduced bone mass and reduced bone quality which understandably results in an increase in the fragility of the bone structure. These changes lead to the bone being at a higher susceptibility to fracture, classically presenting as low trauma (areas such as the wrist or neck of femur), or pathological and sometimes asymptomatic in the spine. 22
Osteoporosis Scenario 1 Referral She does not have any absorption issues, problems with her gut or bowel and June is an 85 year old female who reports eating a varied diet. fractured her wrist after a fall. She is otherwise fit and well. She has no family history of Osteoporosis and does not think either of her parents Further Subjective Information sustained any fractures. 6 weeks ago, June slipped in her kitchen Social Factors landing on her outstretched right arm. She fractured her wrist and was casted. June is a retired teacher. She enjoys She did not require a Open Reduction and socialising with friends and doesn’t Internal Fixation. Since coming out of the formally exercise. She doesn’t smoke or cast her wrist is stiff and lacks strength. drink alcohol and has a BMI of 19. She is relatively pain free. She reports her balance as reasonable, and although is a little concerned she may fall again has been going out, doing her shopping and socialising Past Medical History June is fit and well other than her recent fracture. She does not take any prescribed medications and has never required steroids. She is a little concerned about her balance following her fall but denies true anxiety or depression. She sustained a tibia and fibula fracture 2 years ago after falling down some steps. She reports she recovered well from this. Clinical Reasoning Activity From the case presentation note down the indicators that June could have Osteoporosis: 23
Osteoporosis Scenario 1 June warrants investigation for Investigations Osteoporosis. Complete a bone density risk assessment - 2 fractures in the last 2 years (a FRAX score is well validated) - BMI on the low end of normal range If appropriate and available refer for: - Female aged 85 - DEXA scanning Next Steps Onwards Referral Explain to June that because of her recent fractures,it would be prudent to Refer to GP if DEXA scan shows investigate her bone density further, Osteoporosis or Osteopenia OR if the Osteoporosis is extremely common in FRAX score is high enough to warrant older people and can be well managed commencing bone protection. with a combination of bone protection and load based exercise. Provide June with a graded exercise program that includes load bearing and balance components. Manage her functional deficits in the wrist appropriately. Learning Points. Osteoporosis is likely underdiagnosed in Increasing age and being female the population significantly increase risk Exercise can improve bone density and Assessment of fracture risk is simple and reduce falls risk and should be very quick strongly encouraged 24
Osteoporosis Scenario 2 Referral He has no family history of Osteoporosis, He does not think either of his parents Mark is a 50 year old male with long sustained any fractures. standing Rheumatoid Arthritis (RA). He takes biologic medications and has a Social Factors limited walking distance. Mark has not worked since he was Further Subjective Information diagnosed with RA. He doesn’t go out much and has quite a low activity level. Mark has relatively poor function, his He smokes 15/day, drinks 2 glasses of walking distance is limited and he fatigues wine/day and has a BMI of 26. easily. He was diagnosed with RA aged 20 and has taken a great many medications over this time frame including multiple courses of high dose steroids to manage his arthritis symptoms. He has multiple joint pains and joint deformities. Past Medical History Mark fatigues easily, takes ramipril for high blood pressure, biologics and Methotrexate for his RA and codeine for pain. He has had multiple courses of high dose steroids, the most recent of which was last year where he had 40mg for 4 weeks and then the dose was titrated. He does not have any absorption issues, problems with his gut or bowel and reports eating a varied diet. Clinical Reasoning Activity From the case presentation note down the indicators that Mark could have Osteoporosis: 25
Osteoporosis Scenario 2 Mark warrants investigation for Discuss his general health behaviours. Osteoporosis. Smoking and alcohol are detrimental to bone density but also to outcomes in RA. - Long term inflammatory Consider onward referrals to assist with arthropathies increase the risk of this. Osteoporosis - High dose steroids are a strong risk Try to determine the circumstances that factor for Osteoporosis are leading to such low activity levels. - He has a low activity level and poor Anxiety, depression and/or loneliness may general health including smoking and be factors keeping Mark from increasing alcohol his activity. Social prescribing may be of benefit in his case. Next Steps Investigations Explain to Mark that he has a number of risk factors for low bone density and it Complete a bone density risk assessment would be prudent to investigate this (a FRAX score is well validated) further. Osteoporosis can be well If appropriate and available refer for: managed with a combination of bone protection and load based exercise and is - DEXA scanning easier to maintain bone density if Onwards Referral assessed earlier. Refer to GP if DEXA scan shows Discuss with Mark a graded exercise Osteoporosis or Osteopenia OR if the program that includes load bearing and FRAX score is high enough to warrant balance components tailored to his commencing bone protection. individual circumstances. Learning Points. Inflammatory Arthropathies increase the General health, including mental health risk of low bone density via a number of can increase risk and also contribute to different routes low activity levels A FRAX should be carried out yearly in all Recognising people at risk of low bone patients with inflammatory arthropathy density before they sustain a fracture is of very high importance 26
4 Gout Gout is a type of inflammatory arthritis. It is characterised by acute attacks of pain, redness, swelling and heat of the joint. Onset of symptoms is usually during the night and will peak after 12-24 hours. The pain is severe and many attend A+E with the symptoms. Gout has overtaken Rheumatoid Arthritis as the Rheumatological condition with the most hospital admissions per year. Aspiration of the joint often reveals urate crystals which are what set off the synovitis. The formation of these crystals can be either due to an excess of Urea in the body (90%), or a reduced ability to produce Urate (which metabolises Urea). 27
Gout Scenario 1 Referral It is not better or worse at night, in the morning or during the day. Arnold is a 65 year old male complaining of episodic right big toe pain and swelling. Aggravating/Easing He takes ramipril for high blood pressure. He doesn’t think anything causes an Further Subjective Information episode to occur. When he has the symptoms, weightbearing, having the Arnold reports having approximately 5 sheets touching his toe and moving the episodes of severe right big toe pain over joint will aggravate his pain. the last year. Once it was so severe he thought he had suffered a fracture so Past Medical History attended A+E. They performed an Xray He has high blood pressure and takes and there was no fracture. ramipril. He does not take any other He does not currently report any pain as prescribed medications. He denies any the most recent episode settled while he sexually transmitted infections and use of was waiting for this appointment. He steroids. He feels well in himself and describes the episodes as being of denies feeling anxious or depressed. insidious onset, with pain, redness, He has no personal or family history of swelling and heat at the 1st Metatarsal psoriasis, iritis/uveitis, crohns/colitis, or Phalangeal Joint (MTPJ). He can struggle inflammatory arthritis. to walk and the pain will throb and keep him awake at night. The episodes of pain Social Factors last for approximately 4-6 days and then He works at a supermarket on checkout start to improve. and walks a mile to and from work. He Arnold is concerned due to the number of smokes 20/day and has done for 40 years. episodes of pain he has had, and that they He drinks 2-4 bottles of wine a night at keep occurring even though he doesn’t the weekend and has a BMI of 36. think he is triggering them in any way. 24 hour pattern During an episode of pain, the big toe is constantly painful until it resolves. Clinical Reasoning Activity From the case presentation note down the indicators that 28 Arnold could have Gout:
Gout Scenario 1 Arnold is presenting with symptoms Discuss general health improvement typical of gout. strategies with Arnold. Reducing BMI, alcohol intake and smoking, and - Most commonly affected joint is the increasing his exercise levels are 1st MTPJ important for both his high blood - Severe, episodic pain with swelling, pressure and gout. Cardiovascular disease redness and heat. risk assessment would also be - Gout is more likely in men and the appropriate. risk is increased with vascular issues, smoking, alcohol intake and high BMI Initial management of the gout should be - Characterised by severe pain, people under the GP. with gout often describe it as the Investigations worst pain they have experienced. If appropriate and available refer for: Next Steps - Blood tests: Uric Acid, ESR, CRP Explain to Arnold that his symptoms are Onwards Referral typical of episodic gout flare ups. His general health and alcohol intake will Refer to GP for management make him much more susceptible to suffering further flare ups. Learning Points. Poor general health and Male sex are The 1st MTPJ is the most common strong risk factors for developing gout location for gout symptoms Alcohol intake and smoking increase the Episodic flare ups are common risk of developing gout Severe pain and inflammation are characteristic symptoms 29
Gout Scenario 2 Referral The stiffness will reoccur if he rests. He struggles to sleep at night as the ankle Chris is a 40 year old male complaining of aches. ankle pain and swelling for 4 days following a particularly intense crossfit Aggravating/Easing session. He is insulin dependent due to Rest will aggravate the symptoms when Type 1 Diabetes. he then starts to walk and the ankle can Further subjective information feel very stiff. Activity does not aggravate the symptoms other than for 30 minutes 5 days ago Chris took part in a very after rest. difficult crossfit session which involved many more box jumps than he is used to. Past Medical History He attends crossfit 5 times per week and He has Type 1 Diabetes and takes insulin. has not had any previous issues with this. He reports that the diabetes is well He does not recall a specific injury and controlled and he has regular reviews. He managed the workout well. The pain does not take any other prescribed started in the middle of the night. He medications. He denies any sexually awoke with ankle pain around 3am and transmitted infections and use of steroids. the pain deteriorated from there. He He feels well in himself but slightly considered attending A+E in the morning fatigued due to interrupted sleep. He due to the pain. It had become swollen, denies feeling anxious or depressed. hot and red and he was struggling to weightbear. He thought he might have a He has no personal or family history of fracture. The pain started to improve a psoriasis, iritis/uveitis, crohns/colitis. His little so he decided to wait it out. father and uncle had gout. The ankle remains diffusely swollen, Social Factors warm and painful. He has stiffness most He works at a desk as a mechanical of the time in the ankle. The pain remains engineer. He attends crossfit regularly and relatively constant irrelevant of the describes himself as very fit. He doesn’t amount of activity he does. There is some smoke or drink alcohol and has a BMI of relief with ibuprofen. 24. He remains concerned about a stress 24 hour pattern fracture. The pain and stiffness is worst in the morning and improves after approximately 1 hour. 30
Gout Scenario 2 Clinical Reasoning Activity From the case presentation note down the indicators that Chris could have Gout: Chris is presenting with symptoms His symptoms are not consistent with a suspicious of gout. stress fracture and he did not sustain a clear injury during the session. Reassure - Pain onset during the night, Chris he already lives a healthy lifestyle escalating and peaking after a few and he should continue this as much as hours possible to improve his chances of a good - Pain and stiffness in the morning for outcome. Initial management of gout 1 hour should be under the GP. - Worse with rest - Strong Family history of gout and Investigations Type 1 Diabetes If appropriate and available refer for: - Eased by NSAIDs - Blood tests: Uric Acid, ESR, CRP Next Steps Onwards Referral Explain to Chris that his symptoms are consistent with an onset of gout. His Refer to GP for initial management of diabetes and family history make him Gout flare more susceptible to gout. Learning Points. Symptom onset in this case is important Gout is the most prevalent inflammatory as the timing and initial escalation give arthritis and men are more susceptible the clue to the diagnosis Chronic conditions such as diabetes increase the risk of developing gout 31
5 Systemic Lupus Erythematosus Systemic Lupus Erythematosus is a highly variable, multi- systemic, auto-immune condition. It can affect a variety of organs with different severity and timelines. It is most common in Women and has an increased prevalence in Afro- Caribbeans. Musculoskeletal symptoms are vague and diffuse and significant fatigue often accompanies these muscle and joint aches. Characteristic rashes are important clinical entities. SLE is often mistaken for other conditions such as Fibromyalgia. 32
Systemic Lupus Erythematosus Scenario Referral When she does wake, the aching is there to a similar level as before she fell asleep. Mary is a 30 year old female with diffuse aching all around her body, she doesn’t There is no clear pattern through the day. take any regular medications. The aching is better when she is distracted. Further Subjective Information Past Medical History Mary has had diffuse aching all around her body for approximately 6 weeks. The Mary does not report any other medical intensity and location of the aching is issues with regards to her heart, thyroid, variable and seems related to how tired neurological issues, asthma or diabetes. she is. She has always been a poor sleeper She has not been unwell over the last but in the last 6 weeks she has had year, denies any sexually transmitted significantly worse fatigue. She generally infections and has never taken steroids. feels unwell and run down but denies any She denies any anxiety but is feeling down specific symptoms like nausea, dizziness lately because of the symptoms. or pyrexia. Mary reports she has had 3 miscarriages She was previously fit and well. She has over the last 7 years. She and her husband always slept poorly but this has not are continuing to try and have a baby. She previously impacted on her function. Now has also had a rash across her face at she struggles to concentrate and feels times over the last 6 weeks which has not very lethargic. been itchy or sore. It is not visually present in clinic today. The aching around her body does not particularly affect her function but is Social Factors significant enough to affect her mood. Mary moved to the UK from Jamaica 3 She is fed up of not feeling well and not years ago with her husband. She does not having an answer to what is happening. work, but spends her time cooking, 24 hour pattern cleaning and meeting with her friends. Her husband works in the banking sector Mary is tired all the time. The general and they travel back to Jamaica aching is more noticeable when she is not approximately every 3 months for his distracted and this making it difficult to work or to visit family. fall asleep at night. She has always woken through the night and does not think this Mary does not smoke or drink alcohol. is worse. Her BMI is 26. 33
Systemic Lupus Erythematosus Scenario Clinical Reasoning Activity From the case presentation note down the indicators that Mary could have Systemic Lupus Erythematosus (SLE): Mary warrants investigation for SLE. She already leads quite a healthy lifestyle so encourage her to continue this as - Diffuse aching and fatigue much as possible. - Females carry a far higher risk of developing SLE Investigations - Afro-Caribbeans carry a higher risk of Blood tests: (personally I would leave this developing SLE to the Rheumatology department) - Multiple miscarriages may indicate anti-phospholipid syndrome which is ANA sometimes associated with SLE Onwards Referral - Peak age of onset is in the reproductive years (15-44) Refer to Rheumatology for further investigations and commencement of Next Steps appropriate treatment as necessary. Explain to Mary that her symptoms warrant further investigation under Rheumatology for SLE. This is the best place to determine the diagnosis and rule out any other causes. Discuss with her that although SLE is relatively rare, female sex and Afro-Caribbean ethnicity significantly increase her likelihood of developing the condition. Discuss pacing strategies that may help her during the day to manage her fatigue symptoms. Encourage her to maintain her activity levels as much as possible as this will be beneficial in the longer term and mitigate any loss of fitness levels. 34
Systemic Lupus Erythematosus Scenario Learning Points. SLE masquerades as any number of Understanding multisystem effects is key musculoskeletal condition so it is easy to to recognition. Look for renal disorders, misdiagnose as fibromyalgia or other blood disorders, rashes, serositis, and similar clinical entities arthritis Significantly more common in women (approx. 10:1 ratio) and higher risk in people of Afro-Caribbean descent A vital point is that rashes and skin conditions in text books are often shown on Caucasian skin. These changes in people who are not of Caucasian descent may look different to these images and are often more subtle. Be mindful of this when assessing for skin changes and conditions. 35
6 Sjogren’s Syndrome Sjogren’s Syndrome is an inflammatory connective tissue disorder affecting the secretory glands, such as in the mouth and the eyes. Musculoskeletal symptoms are often vague and diffuse with associated fatigue. Significantly more common in women and peak onset of 50-60. Sjogren’s Syndrome can be the primary condition or it be secondary to another clinically important inflammatory condition such as RA or SLE 36
Sjogren’s Syndrome Scenario Referral She remains tired when she wakes up regardless of the number of hours she has Anna is a 40 year old female with diffuse slept for. muscle aching in her legs. She doesn’t take any prescribed medication. Past Medical History Further Subjective Information Anna does not report any other medical issues with regards to her heart, thyroid, Anna has had diffuse muscle aching in her neurological issues, asthma or diabetes. legs for approximately 6 months. There She has not been unwell over the last was no triggering onset and no change in year, denies any sexually transmitted habits prior. More recently over the last infections and has never taken steroids. 4-6 weeks she has felt very tired all of the She denies any anxiety or depression. time. She reports sleeping well but never feels refreshed. Anna reports very dry eyes. She uses false tears regularly through the day and also The muscle aching does not appear to be has a very dry mouth. She denies any related to anything she does, and remains change in vaginal dryness. She carries a at a similar intensity whether she is busy bottle of water everywhere with her and or resting. It does not impact on her drinks from it regularly during the function but she is feeling down about its appointment. relentless nature. The fatigue is more of an issue as she finds it difficult to Her mother has Rheumatoid Arthritis. concentrate at work and doesn’t feel like There is no other family history of she wants to engage in her hobbies. inflammatory conditions. She has not had any previous injuries. Social Factors Over the last 6 months she has had very Anna is an accountant and works at a occasional hand and foot pains which desk. She usually enjoys playing regular have been a similar type of aching, but tennis but has not being doing this resolve after 6 hours or by the next day. recently due to the worsening fatigue. 24 hour pattern Anna does not smoke or drink alcohol. She thinks the aching may be slightly Her BMI is 24. worse in the mornings but not significantly. She does not struggle to sleep and is not woken at all by the symptoms. 37
Sjogren’s Syndrome Scenario Clinical Reasoning Activity From the case presentation note down the indicators that Anna could have Sjogren’s Syndrome: Anna warrants investigation for Her Mother having RA slightly increases Sjogren’s Syndrome. her risk of developing an inflammatory condition. - Muscle aching (myalgia) and fatigue with possible hand and foot joint Discuss pacing strategies that may help aching (arthralgia) her to manage her fatigue symptoms - Females carry a far higher risk of during the day. Encourage her to maintain developing Sjogren’s Syndrome her activity levels as much as possible as - Dry eyes and dry mouth are this will be beneficial in the longer term characteristic of Sjogren’s Syndrome and mitigate any loss of fitness levels. - A family history of inflammatory Investigations arthropathy - Peak age of onset is 40-60 If you are confident performing a Schirmer’s test then this can provide an Next Steps objective measure of eye dryness in clinic. Explain to Anna that her symptoms Onwards Referral warrant further specialist investigation. The dry eyes, dry mouth, fatigue and Refer to Rheumatology for further aching may all be related to the one investigations and commencement of condition. appropriate treatment as necessary. Learning Points. Musculoskeletal symptoms of Sjogrens It is key to ask about fatigue levels and syndrome are often vague and diffuse possible causes Ensuring in-depth questioning about eye, mouth and vaginal secretions are a Sjogrens syndrome is far more common vital component of recognising a in women than men (approx. 9:1 ratio) potential case 38
7 Polymyalgia Rheumatica Polymyalgia Rheumatica is an inflammatory condition, characterised by shoulder and/or pelvic girdle pain and stiffness. The mainstay of treatment is pharmacological, usually involving steroids. Onset is very unlikely prior to the age of 50, peak onset is 65 with women being affected at 3x more than men. There shouldn’t be any muscle weakness at presentation and likely proximal muscle tenderness to palpation. 39
Polymyalgia Rheumatica Scenario Referral The pain feels quite diffuse across the whole of the shoulders and between her Sally is a 65 year old female with bilateral scapulae. shoulder pain. She doesn’t take any prescribed medications. She is not woken at night with the symptoms and feels her sleep in general is Further Subjective Information unaffected. Sally has had bilateral shoulder pain for Past Medical History approximately 3 months. She thinks this started after she helped her daughter Sally does not report any other medical move house. She denies true loss of range issues with regards to her heart, thyroid, of motion but both shoulders feel very neurological issues, asthma or diabetes. stiff when she tries to move her arms over She has not been unwell over the last her head or behind her back. year, denies any sexually transmitted infections and has never taken steroids. She has not previously had any She denies any anxiety but has suffered musculoskeletal problems. She is finding from depression for a number of years. the pain and stiffness limits her from her She currently does not take any favourite hobby gardening, and reports medications for this but has done in the less motivation because of the past. discomfort. She denies any other current joint pains or problems. Sally denies any other joint pains, history of inflammatory conditions and has no 24 hour pattern family history of inflammatory conditions. Sally finds the symptoms are worse first Social Factors thing in the morning for approximately 1 hour which really affects her dressing as Sally is a retired vet. She gardens for a few her shoulders are very stiff and painful. hours every day and is finding it They ease up to a degree after this time frustrating that she can’t maintain this but remain uncomfortable and stiff level of activity. through the day. Mary does not smoke or drink alcohol. Her BMI is 30. Clinical Reasoning Activity From the case presentation note down the indicators that Sally could have Polymyalgia Rheumatica (PMR) 40
Polymyalgia Rheumatica Scenario Sally warrants investigation for PMR. A graded exercise program can be helpful to maintain function in the shoulders and - Bilateral shoulder pain and stiffness increase current function. Unfortunately - Symptoms worse in the mornings it tends not to affect the pain levels or - Diffuse symptoms around the whole feelings of stiffness. Discuss her general shoulder girdle health as her high BMI will be - 65 year old female with a high BMI is contributing to raised systemic the classic demographic for PMR inflammation and reducing this will onset improve the likelihood of a positive - Depression is linked to PMR in many outcome regardless of the diagnosis. cases Investigations Next Steps Blood tests: Explain to Sally that her symptoms may be related to PMR and further investigation - ESR (>40), CRP is warranted to enable appropriate Currently no valid imaging unless to rule treatment and rule out any other cause out other implicated conditions. for the symptoms. Discuss that her demographics and symptom presentation Onwards Referral make it suspicious that this is the cause Refer according to local pathways, this is for her symptoms. either to the GP or to a Rheumatology consultant. Learning Points. Bilateral shoulder pain and stiffness is a ESR of >40 is almost always present in key symptomatic feature of PMR (90% of PMR and a negative result all but rules out cases) the condition 65 years old is the peak onset, women Pelvic girdle symptoms may also be have a higher incidence (approx. 3:1) and implicated and in 10% of cases will be high BMI will increase risk of developing the only symptom presentation the condition 41
8 Reactive Arthritis Reactive arthritis is a varied condition triggered by an extra- articular infection usually of gastrointestinal (GI) or Genitourinary (GU) origin. Reactive arthritis is often clinically indistinguishable from other arthropathies such as AxSpA or RA. Recognition of the triggering event is key. Occurring in younger Caucasian people aged 20-40, men are much more likely to have the GU origin than women. GI origin has an equal prevalence. Symptom onset is usually within 2-6 weeks of infection. 42
Reactive Arthritis Scenario 1 Referral He wakes in the second half of the night with back pain and he has to get out of Dean is a 20 year old Caucasian male with bed and walk around to ease it enough low back pain. He doesn’t take any for him to lay down and go back to sleep. prescribed medications. Past Medical History Further Subjective Information Dean does not report any other medical Dean reports 6 weeks of severe low back issues with regards to his heart, thyroid, pain and stiffness. He has no prior history neurological issues, asthma or diabetes. of back pain and can not think of a He has not been unwell over the last year, specific trigger to his symptoms. He has denies any history of sexually transmitted been off work for the whole 6 weeks since infections and has never taken steroids. the symptoms started. He does not suffer from anxiety or He denies being unwell over the last 6 depression. months and is usually very fit and healthy. Dean denies any other joint pains, history He was recently (8 weeks ago) on holiday of inflammatory conditions. His father has in Magaluf and admits to having Ankylosing Spondylitis. unprotected intercourse with several partners while he was there. He has not Social Factors considering getting checked for an STI. Dean is a bricklayer. He is extremely 24 hour pattern active, going to the gym most days after work and playing rugby at the weekends. Dean’s symptoms are severe in the mornings. The pain is much worse with Dean smokes very occasionally and drinks significant stiffness for up to 4 hours. He alcohol on holiday only. His BMI is 25. finds he is much better during the day if he keeps moving. If he sits to watch television or even to eat a meal his back stiffens up again and he has to walk around to ease it off. Clinical Reasoning Activity From the case presentation note down the indicators that Dean could have Reactive Arthritis: 43
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