Pharmaceutical & Biotechnology Sector: 2021 Report V.E, AN AFFILIATE OF MOODY'S - Vigeo Eiris

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Pharmaceutical & Biotechnology Sector: 2021 Report V.E, AN AFFILIATE OF MOODY'S - Vigeo Eiris
V.E– Sector Report
                     J AN U ARY 2 02 1

                                                  188 companies in the sector

   Pharmaceutical & Biotechnology
   Sector:
   2021 Report

                                         V.E, AN AFFILIATE OF MOODY’S
ESG Sector Report

Outline
Key findings 2021 ……………………………………………………………………………………………………………..                                  04
Sector context …………………………………………………………………………………………………………………..                                   06
Sector performances and trends …………………………………………………………………………………………….                            07
Sector performance and rankings …………………………………………………………………………………………..                           10

                   To access the full report, please contact investorcustomer.service@vigeo-eiris.com

Head of ESG Research: Cristina Daverio
cristina.daverio@vigeo-eiris.com
+39 02 27727141

Research manager: Zineb Raji
Zineb.Raji@vigeo-eiris.com

Sector expert: Fatima-Ezzahra Zouita

Sector analysts:

Aida Jorquera                  Oumaima Doukkane
Chong-Ren Jian                 Oumayma Oummouch
Fatima-Ezzahra Zouita          Salima Bouchama
Faustine Sourdin               Salima Kabbaj
Giannina Salvo                 Sarah Cherrat
Lauren Boulie                  Sarra El Hakour
Nada Snoussi                   Soumaya Najib
ESG Sector Report

ABOUT THIS REPORT
Companies considered in this report belong to the following geographical zones: Asia Pacific, North America, Europe, Emerging
Market. Currently, V.E Equitics research covers around 4,800 issuers divided into 39 sectors.

Periods considered:

 Current data: To compute average performances, we consider data from the latest review of each company covered in the report
  within the last 24 months as of the last day of the month prior to the sector report publication (e.g. 31/05/2020 for a report
  released in June 2020)
 Historical data: To compute average performances, we consider data from the latest review of each company covered in the
  report rated within the last 24 months preceding the last day of [year - 1 month] before the sector report publication (e.g.
  31/05/2018 and 31/05/2017 for a report released in June 2019)
 Sector data: For each company of the sector, data considered in average calculations, we take data from latest Rating, Rating-1
  and Rating-2, excluding outdated publications (which have been adjusted by errata or updated through alerts).
 Universe data: We take into account all latest delivered information and companies on the day we extract data.
 Rankings: Sector rankings are computed as of 31/12 of each fiscal year.
 Percentages: Figures included in this report have been rounded up or down automatically and therefore may not add up to 100%.

ABOUT V.E
V.E is an independent international provider of environmental, social and governance (ESG) research and services for investors and
public and private organisations. We undertake risk assessments and evaluate the level of integration of sustainability factors within
the strategy and operations of organisations.

V.E offers a wide range of services:

              −    For investors: decision-making support covering all sustainable and ethical investment approaches (including ratings,
                   databases, sector analyses, portfolio analyses, structured products, indices and more).
              −    For companies and organisations: supporting the integration of ESG criteria into business functions and strategic
                   operations (including sustainable bonds, corporate ratings, CSR evaluations and more).

V.E obtained ISO 9001: 2015 certification for its processes relating to methodology, rating, sale and delivery of its data to all types of
investors.

With a team of more than 240 experts of 28 different nationalities, V.E is present in Paris, London, Brussels, Casablanca, Hong Kong,
Milan, New York, Rabat and Santiago. The V.E Global Network, comprising 4 exclusive research partners, is present in Brazil, Germany,
Israel and Japan. For more information: www.vigeo-eiris.com

Pharmaceutical & Biotechnology – January 2021                                                                                     2
ESG Sector Report

KEY   FINDINGS   2021–                                                                                                               PHARMACEUTICAL                                                            &
BIOTECHNOLOGY SECTOR
Sector average
performance                                                                                                          Top performers
Universe average                                           10                        33             62
performance                                                                                                          Europe: GlaxoSmithkline (62/100)
                                                                     29                                              North America: Johnson & Johnson (53/100)
Sector minimum and
maximum
                                                                                                                     Asia Pacific: Takeda Pharmaceutical (51/100)
                                             0                                                                100    Emerging Markets: Aspen Pharmacare Holdings ; Dr Reddy’s
ESG Performances – Sector & Universe                                                                                 Laboratories (56/100)

 Environment
         Environment                             21
                                                                      29                                             Most improved since 2018
                                                                                                                     Europe: Grifols; Genfit (+11)
                                                                          31
                                                                                                                     North America: Alkermes (+5)
Social             Social                                  29
                                                                                                                     Asia Pacific: Kissei Pharmaceutical (+15)
Governance                                                                           40
                                                                                                                     Emerging Markets: Hanmi Pharmaceutical (+14)
             Governance                                              36

Domain performances– Sector & Universe
                            0                                                                                 100    Most material drivers
                                                                                          44
                                                                                                                             ADVANCED
Corporate
   Corporate Governance                                                        42
                                                                                                                              (60-100)
Governance
                                                                           34                                                  ROBUST
Business
     Business Behaviour                                     31                                                                 (50-59)
Behaviour
                                                                      31
                                                                                                                                                   •   Board of directors
Community
   Community Involvement                              25                                                                                           •   Information to patients
Involvement                                                                                                                    LIMITED             •   Corruption
                                                                                                                                                   •
                                                                26
                                                                                                                                (30-49)                Fundamental human rights
HumanHuman Resources                              23
Resources                                                                                                                                          •   Product safety
                                                                                37
                                                                                                                                                   •   Anti-competitive practices
Human Rights
       Human Rights                                              34
                                                                                                                                                   •   Sustainable healthcare systems
                                                                     29
                                                                                                                                                   •   Career management
Environment
                                                                                                                                                   •
         Environment                             21
                                                                                                                                WEAK                   Accidental pollution
                                                                                                                                (0-29)             •   Responsible lobbying
                                                                                                                                                   •   Access to medicines and societal impacts of products
Risk Mitigation – Sector & Universe
                                        10                            35                            69
Reputation
           Reputation                                      29

                                                            29                                 56
                                                                                                                     Carbon footprint
                                    7                                                                                Share of companies in each level of carbon footprint
Human Capital
   Human Capital                                      26
                                                                                                                                               Moderate              Significant         High         Intense
                                4                                     35                             71
 Operational
Operational
                                                                                                                       Sector (%)                                  71                                 25      4
 EfficiencyEfficiency                                       31
                                                                                                                     Universe (%)                          53                            29              13 5
                                         12                           35                                 73
Legal Security
      Legal Security                                            34                                                   Energy transition
                                                                                                                     Share of companies in each level of energy transition performance
                        0                                                                                      100

Takeaways                                                                                                              Sector (%)
                                                                                                                                               Weak               Limited
                                                                                                                                                                    73
                                                                                                                                                                                   Robust          Advanced
                                                                                                                                                                                                    15    7 4
        Can voluntary licensing agreements and waiver of rights by patent right                                     Universe (%)                               61                              26       7 5
         holders help to increase access to medicines during a pandemic?
        Covid-19: an urgent call to put business ethics before profit                                               Sustainable goods & services
                                                                                                                     Share of companies in each level of involvement in goods and services contributing to
        Despite slight improvement, the sector continues to demonstrate a limited
                                                                                                                     sustainable development
         approach to product safety
        Pharmaceutical & biotechnology companies and animal testing: an ongoing                                                               None               Minor          Significant            Major
         debate
                                                                                                                        Sector (%)   3 6 3                                       88
        Responsible marketing tactics and proper information to customers are still
                                                                                                                      Universe (%)                 36                               48                     5    11
         a major challenge                                                                                           Controversies risk mitigation
                                                                                                                     Share of companies in each performance level in terms of controversy risk management
                                                                                                                                                                                                 Number of companies in
                                                                                                                          Weak           Limited       Robust     Advanced    No controversies   Warning list : 9

                                                                                                                           10             16           2                            72

Pharmaceutical & Biotechnology – January 2021                                                                                                                                                          3
ESG Sector Report

SECTOR CONTEXT
Sector overview
         Number of companies
                                                          V.E’s Pharmaceuticals and Biotechnology sector is composed of 188 companies. These
                                                          companies are engaged in the research, development, manufacturing, and
              Sector                             188      distribution of drugs for human or veterinary use. The medicines produced are aimed
                                                          to cure or manage diseases, or to prevent infection.
             Europe                    59
                                                          The industry’s value chain starts with the manufacturing of medicines, which involves
    North America                      60                 research and development in addition to regulatory approval. The second phase
                                                          includes the distribution and handling of medicines from the manufacturer to the end
         Asia-Pacific             40                      user (through retail, pharmacy, hospital, or dispensing doctors). The final step in the
                                                          value chain is the commercialisation and the provision of the right medicine dosage,
 Emerging Market                  29                      form, and advice to the right patient.

Companies inclusions in V.E – Euronext Indices

     World 120              Europe 120             Eurozone 120             US 50               France 20         UK 20            Benelux 20

 Takeda
                        GlaxoSmithkline         Grifols             Merck & Company        NA               GlaxoSmithkline   NA
 Pharmaceutical

 Merck & Company        Novozymes                                   Amgen

 Amgen                  Grifols                                     Abbott Laboratories

                                                                    Bristol Myers Squibb

Subsector description

The Pharmaceuticals and Biotechnology sector is composed of two broad sub-sectors: biotechnology companies and traditional
pharmaceuticals. The primary difference between the two is the method by which they produce drugs:
     -    Pharmaceutical companies manufacture drugs through a series of chemical synthesis. Based on their size and strategy,
          pharmaceutical companies may conduct extensive in-house research or seek to license drugs from other pharmaceutical or
          biotechnology companies. Some pharmaceutical companies are considered as specialty pharma since they focus on specific
          activities such as R&D only or marketing and sales only. Pharmaceutical companies generally hold the exclusive rights to
          manufacture and distribute their drugs for five years.

     -    Biotechnology companies produce drugs with a biological basis that are manufactured in living organisms such as bacteria
          or enzymes. These companies are working to duplicate or change the function of a living cell and could use genetics research
          to develop products for human diseases and conditions. Biotechnology companies hold their patents for 12 years.

Pharmaceutical & Biotechnology – January 2021                                                                                              4
ESG Sector Report

Sector reporting rates

Data displayed below reflects the evolution over the past three years of the average rate of ESG indicators analysed by V.E that
companies report against, with notably:
 Spread per geographical area
 Spread per materiality of ESG drivers analysed for the sector

In January 2021, the reporting rate of V.E’s global universe stood at 65%.

  100
                                                                                 Most material ESG drivers - Weighted at 3
   90
                                                                       100                               69                2018/12
   80                                                                                   58      60
   70                                                                                                                      2019/12
   60                                                                        0                                             2020/12
   50                                                                            Highly material ESG drivers - Weighted at 2
   40                                                 2018/12
                                                                       100                                                 2018/12
                                                                                        51      53       61
   30                                                 2019/12
                                                                                                                           2019/12
   20                                                 2020/12
                                                                             0                                             2020/12
   10
     0                                                                              Material ESG drivers - Weighted at 1
                                                                       100                                                 2018/12
                                                                                                         55
                                                                                        38      36                         2019/12

                                                                             0                                             2020/12

Pharmaceutical & Biotechnology – January 2021                                                                                  5
ESG Sector Report

SECTOR PERFORMANCES AND TRENDS
Impacts
Sector involvement in products and services considered sustainable given their positive impact on social and environmental issues

      Sector                                                          Universe
    3%              6% 3%

                                                Major                                     11%              Major
                                                                                                5%
                                                Significant                  36%                           Significant
                                                Minor                                                      Minor
                                                None                                                       None
                             88%
                                                                                            48%

The involvement in sustainable products and services of companies in this industry is high overall compared to the whole V.E universe.
Out of all companies covered by V.E’s research in the Pharmaceuticals and Biotechnology sector, 97% display involvement in
sustainable products and services, with the majority (88%) displaying major involvement.
The involvement relates to 24 different activities that address sustainable development challenges, notably pharmaceuticals,
pharmaceutical materials and medical technology that together represent more than three quarters of the industry’s involvement.

Case study:
H Lundbeck displays one of the highest levels of involvement (100%) in products and services contributing to sustainable
development addressing the theme Health.
   Pharmaceuticals: Lundbeck produces pharmaceuticals for the treatment of psychiatric and neurological disorders, including
    depression, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy, alcohol dependence, and
    insomnia. Its key products are notably Rexulti (depression and schizophrenia), Brintellix (depression), Abilify Maintena
    (schizophrenia), Northera and Onfi (epilepsy). All of the Company's revenue is derived from the sale of pharmaceuticals.

Pharmaceutical & Biotechnology – January 2021                                                                                 6
ESG Sector Report

Sustainable Development Goals
V.E assesses the contribution of companies to the achievement of sustainable development goals (SDGs) through their behaviours
and products/services.

    Pharmaceuticals & Biotechnology                                                Universe
              4%
                    5%                                                                      6% 5%
                                                 Highly Positive                                                  Highly Positive
                           23%                                                                          19%
                                                 Positive                          25%                            Positive
                                                 Marginal                                                         Marginal

                                                 Adverse                                                          Adverse
              68%                                                                                 45%             Highly Adverse
                                                 Highly Adverse

 Almost a quarter of companies in the Pharmaceuticals and Biotechnology sector have a highly positive contribution to the SDGs
  Those companies combine an ESG performance above geographical peers, a relevant sustainable offering, face no critical
  controversies and are not involved in controversial activities. The sector’s contribution is aligned with the total positive
  contribution of all sectors in the V.E’s ratings universe.
 Most companies in the sector have only marginal contributions to SDGs, with the remaining 9% having adverse to highly adverse
  contributions. The sector’s adverse to highly adverse contributions are lower than the 31% combined contribution of all sectors
  in the V.E’s ratings universe.
 On one hand, the sector has a poor record in terms of social welfare - 43% percent of the companies display a combined adverse
  to highly adverse impact, while 42% have only a marginal contribution.
 On the other hand, almost all companies in the sector display positive to highly positive contributions to enabling healthy lives
  due to the offer of pharmaceuticals, pharmaceutical materials and medical equipment.

Carbon footprint and energy transition

                                 Energy Transition performance          Sector (/100)           Universe (/100)
                                    Energy transition score              Weak - 19                Weak - 26

                                                            Energy transition: Top performers
                                                               GlaxoSmithkline (73/100)

                                                                Novo Nordisk (68/100)

                                                                Roche Holding (66/100)

                                                                    Sanofi (66/100)

Pharmaceutical & Biotechnology – January 2021                                                                                       7
ESG Sector Report

Charts below display the share of companies within each range of carbon footprint and energy transition performance.

                        Carbon footprint                                                              Energy Transition performance
                                                                                   Global
                          71                               25             4      Sector (%)                          73                        15           7 4
                   53                           29              13    5         Universe (%)                    61                        26                7 5
                                                                                  Europe
                             78                                 19        3      Sector (%)                          71                       14        7    8
                        64                            23             9 3        Universe (%)               49                      29              11       11
                                                                               North America
                          73                               18         8          Sector (%)                           78                           10 7 5
                46                         32               16        6         Universe (%)
                                                                                                                  69                           23            52
                                                                                Asia Pacific
                                                                                Sector (%)
                             78                                 23                                           55                          33                 13
                                                                                Universe (%)
                     55                          30              11 3                                           64                            28             53
                                                                              Emerging Market
                                                                                 Sector (%)
                45                                   55                                                                    93                                7
                                                                                Universe (%)
              39                     34                    17         9                                            69                           25    52
          Moderate           Significant        High        Intense                                 Weak          Limited       Robust         Advanced

At first sight, the Pharmaceuticals and Biotechnology sector is not a particularly high greenhouse gas (GHG) emitting sector, as
indicated by the 71% of the companies in the sector having a moderate carbon footprint. However, given the size of the global
workforce and the energy needed for chemical processes, heating and cooling, as well as for product transportation, the operations
in this sector can be very carbon intensive and be even dirtier than automotive production operations1.
The management of energy consumption and the impacts generated from transportation are the main aspects on which companies
in this sector can work to reduce their GHG emissions and successfully transition to a low carbon economy. Yet, the sector’s average
performance in regard to both aspects is weak, standing at 28/100 for the topic of Minimising environmental impacts from energy
use (ENV 2.2), and 10/100 for the topic of Management of environmental impacts from transportation (ENV 2.7). Over the last two
years, these scores have improved by only 2.5 and 1 points for ENV2.2 and ENV 2.7, respectively.
To enhance their performance for energy efficiency and emission reductions, companies from this sector can upgrade their
equipment, switch to alternative fuels, and use state of the art technologies to produce renewable energies. Concerning
transportation, companies can improve by taking steps to reduce the emissions related to the transport of their personnel. They can
also rationalise product transport flows, and make contractual commitments with transport logistic firms to encourage the mitigation
of negative impacts from transportation.
Overall, the sector demonstrates a weak energy transition performance with an average score of 19/100. Since 2019, this score has
increased by only one point. This leads to a low level of assurance on the sector’s response and capacity to manage the risks and
opportunities associated with the transition to a low-carbon economy.

Social Impacts and Value Creation

         Social impacts - Key Indicators                                                                    Sector (%)             Universe (%)

  1
      Belkhir, L., & Elmeligi, A. (2019). Carbon footprint of the global pharmaceutical industry and relative impact of its major players. Journal of Cleaner
      Production, 214, 185-194.

Pharmaceutical & Biotechnology – January 2021                                                                                                           8
ESG Sector Report

      Percentage of women in management                                                                            21.7                      21.5

      Share of companies for which we have no information                                                          0.0                       0.4

      Share of companies with operations in OFCs or jurisdictions considered by the OECD as                        53.2                      53.9
      not compliant enough with tax transparency rules

      Share of companies without operations in such jurisdictions                                                  31.4                      38.9

      Share of companies for which we have no information                                                          15.4                      7.3

      Share of companies signatory to the Global Compact                                                           21.1                      24.2

      Value Creation & Sharing                                                                                 Sector (%)               Universe (%)

      Share of companies transparent on their R&D investments                                                      95.7                      39.8

      Share of companies transparent on the share of added value received by employees                             70.7                      68.3
      relative to shareholders

      Share of companies for which executive variable remuneration is linked to CSR                                8.4                       21.3
      objectives

      Share of companies with comprehensive transparency on taxes2                                                 1.6                       5.8

      Share of companies with significant transparency on taxes3                                                   22.2                      38.2

      Share of companies with partial transparency on taxes4                                                       18.9                      15.2

      Share of companies with insufficient transparency on taxes5                                                  54.6                      38.0

      Share of companies for which we have no information on taxes                                                 2.7                       2.8

  2 In addition to geographical information on taxes paid, sales, operating profit or number of employees, these companies declare the difference between statutory
     tax rates and the rate actually paid.
  3 These companies report on sales, and/or operating profit, and/ or number of employees per operating region and disclose taxes paid by country or region.
  4 These companies’ reporting focuses on taxes paid in countries or regions representing more than 50% of their operations.
  5 These companies report only on gross taxes paid, with no breakdown by region or country.

Pharmaceutical & Biotechnology – January 2021                                                                                                            9
ESG Sector Report

SECTOR PERFORMANCE AND RANKING
       Position of sector versus Universe

                                                Average score    Current rank   Previous rank

       Universe                                           33.4
       Development Banks                                  56.9           1                 1
       Diversified Banks                                  48.1           2                 2
       Specific Purpose Banks & Agencies                  46.7           3                 3
       Waste & Water Utilities                            42.2           4                 4
       Forest Products & Paper                            41.5           5                 5
       Electric & Gas Utilities                           40.3           6                 7
       Luxury Goods & Cosmetics                           39.7           7                 6
       Chemicals                                          38.1           8                 10
       Mining & Metals                                    37.5           9                 12
       Telecommunications                                 37.0          10                 8
       Energy                                             36.8          11                 11
       Publishing                                         36.4          12                 9
       Building Materials                                 34.9          13                 17
       Oil Equipment & Services                           34.8          14                 14
       Retail & Specialised Banks                         34.8          15                 16
       Home Construction                                  34.6          16                 13
       Business Support Services                          34.6          17                 22
       Beverage                                           34.1          18                 15
       Automobiles                                        33.5          19                 19
       Heavy Construction                                 33.4          20                 20
       Technology-Hardware                                33.0          21                 18
       Transport & Logistics                              33.0          22                 25
       Travel & Tourism                                   32.7          23                 26
       Insurance                                          32.7          24                 24
       Financial Services - Real Estate                   32.2          25                 30
       Broadcasting & Advertising                         32.0          26                 23
       Mechanical Components & Equipment                  31.7          27                 32
       Supermarkets                                       31.6          28                 27
       Industrial Goods & Services                        31.5          29                 29
       Health Care Equipment & Services                   31.4          30                 34
       Electric Components & Equipment                    31.0          31                 28
       Aerospace                                          30.8          32                 21
       Financial Services - General                       30.7          33                 33
       Food                                               29.3          34                 37
       Hotel, Leisure Goods & Services                    29.2          35                 36
       Software & IT Services                             29.0          36                 35
       Pharmaceuticals & Biotechnology                    28.9          37                 38
       Tobacco                                            28.9          38                 31
       Specialised Retail                                 27.2          39                 39

Pharmaceutical & Biotechnology – January 2021                                                   10
ESG Sector Report

Performance trends – Global level and per zone

   100
             Sector                           Europe           North America                           Sector performances distribution
       80                                                                                                  1%
                                         33     31     33         28     28        28
                                                                                                        6%
       60                                                                                                                            Weak (0-29)

                                                                                              28%                                    Limited (30-49)
       40
             27        27   29                                                                                                       Robust (50-59)
                                         Asia Pacific         Emerging Market
                                                                                                                      65%
       20                                                                                                                            Advanced (60-100)
                                         23     26     29
                                                                  21     20        23

        0

       Sector performances distribution
            Weak (0-29)          Limited (30-49)        Robust (50-59)             Advanced (60-100)      Sector standard deviation: 10.25

   0              10             20             30           40               50             60            70             80             90            100

                                                                                            Share of companies within each performance level range
 The Pharmaceuticals and Biotechnology sector displays a weak overall CSR performance, which is stable compared to the previous
  review.
 Sector leaders are concentrated in Europe, with an average performance of 33/100, whilst laggards are mostly listed in the
  Emerging Markets region (average performance of 23/100). European companies display a relatively higher level of transparency
  on commitments to CSR issues, as demonstrated by an average overall score of 34/100 on the leadership pillar compared to only
  21/100 for Emerging Markets. When it comes to the implementation pillar, European companies are more communicative on
  measures, with a score of 26/100 compared to 17/100 in Emerging Markets. Moreover, European companies report more on KPIs
  of different CSR issues under review as illustrated by an average overall score of 38/100 on the results pillar compared to 32/100
  in Emerging Markets.

 65% of companies display weak performances, 28% display limited performances and 6% achieve robust performances, while
  only one company achieves an advanced performance. Companies’ performances are relatively heterogeneous as illustrated by
  the 10.25 standard deviation and the scattering of performances.

 GlaxoSmithkline is the leader in the sector with a global performance of 62/100. The company accomplishes the highest score on
  the Corporate Governance (74/100) and Community Involvement (68/100) domains with advanced scores. An equally advanced
  performance of 65/100 is achieved in the Human Rights and Environment domains and a robust score is obtained in the Human
  Resources (56/100) and Business Behaviour (55/100) domains. These distinguished performances are made possible thanks to
  reporting on comprehensive policies, measures and KPIs. This is in addition to demonstrating increased understanding and
  appropriate integration of CSR challenges that are at stakes for the company’s operations at governance level.

Pharmaceutical & Biotechnology – January 2021                                                                                                          11
ESG Sector Report

Management profile
Average performances on the three pillars of CSR assessment

                     Policies                                        Implementation                          Results
 100                                                          100                                  100
   80                                                           80                                  80
   60                                                           60                                  60
   40                                           Sector          40                      Sector      40                       Sector
   20                                           Universe        20                      Universe    20                       Universe
    0                                                            0                                   0

Risk mitigation for strategic assets

Overall, the Pharmaceuticals and Biotechnology sector stands below the average of the universe’s performance for management of
risk factors which impact reputation, human capital, operational efficiency, and legal security.
ESG risk mitigation scores are weak in relation to reputation (29/100) and human capital (26/100) and limited in relation to
operational efficiency (31/100) as well as legal security (34/100). The area of human capital achieves the lowest score as the reported
policies and efforts to manage employee-related impacts (such as the respect and promotion of fundamental labour rights, health
and safety, impact of reorganisations and the management of layoffs, and career development) generally lack substantial and
consistent disclosure across the majority of companies. Although still limited, the highest score is achieved in the area of legal
security. The industry is highly regulated and under significant stakeholder scrutiny, with related exposure to legal and regulatory
risks, companies seem more invested and mobilized to monitor and enhance their internal controls and processes to compliance in
response to heightened transparency expectations and potential controversies. While many controversies are observed within the
Pharmaceuticals and Biotechnology sector, companies are generally considered to be reactive on them. However, proactive
management and corrective measures are not demonstrated, leading to a limited overall score for the sector’s performance on legal
security risk management.

                                          10                    35            69
                                                                                                         Sector average
                                                                                                         performance
                Reputation                           29
                                                                                                         Universe average
                                      7                  29             56                               performance
            Human Capital                           26
                                                                                                         Sector minimum
                                  4                             35             71                        and maximum
     Operational Efficiency                              31

                                           12                   35                 73
             Legal Security                                34

                              0                                                                    100

Pharmaceutical & Biotechnology – January 2021                                                                                  12
ESG Sector Report

Materiality: weighing & performances assessment

V.E Methodology for the Pharmaceuticals & Biotechnology sector has remained unchanged since its previous review.
                    ADVANCED
                               (60-100)
       STRENGTHS

                    ROBUST
                               (50-59)

                                                                                                 •   Board of directors
                                                •   Shareholders
                                                                                                 •   Information to patients
                                                •   Audit & internal controls
                    LIMITED
                               (30-49)

                                                                                                 •   Corruption
                                                •   Non-discrimination and diversity
                                                                                                 •   Fundamental human rights
                                                •   Environmental strategy
                                                                                                 •   Product safety
                                                •   Executive remuneration
                                                                                                 •   Anti-competitive practices
                                                •   Energy
                                                •   Health and safety
                                                •   Fundamental labour rights
                                                •   Social standards in the supply chain         •   Sustainable healthcare systems
                                                •   Environmental standards in the supply        •   Career management
                                                                                                 •
                    WEAK
                               (0-29)

                                                    chain                                            Accidental pollution
       WEAKNESSES

                                                •   Water                                        •   Responsible lobbying
                                                •   Animal testing and biodiversity protection   •   Access to medicines and societal impacts of
                                                •   Reorganisation                                   products
                                                •   Use and disposal of products
                                                •   Atmospheric emissions
                                                •   Transportation
                                          1                            2                                                 3
                                                              MATERIALITY OF THE RISK FACTORS

Pharmaceutical & Biotechnology – January 2021                                                                                         13
ESG Sector Report

DISCLAIMER
© 2020 Vigeo SAS and/or its licensors and subsidiaries (collectively, “V.E”). All rights reserved.
V.E provides its customers with data, information, research, analyses, reports, quantitative model-based scores, assessments and/or other opinions
(collectively, “Research”) with respect to the environmental, social and/or governance (“ESG”) attributes and/or performance of individual issuers
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Pharmaceutical & Biotechnology – January 2021                                                                                                  14
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