National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy - FIRST
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FIRST National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021–2025
Copyright © 2021 Commonwealth of Australia as represented by the Department of Health This work is copyright. You may copy, print, download, display and reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation: (a) do not use the copy or reproduction for any commercial purpose; and (b) retain this copyright notice and all disclaimer notices as part of that copy or reproduction. Apart from rights as permitted by the Copyright Act 1968 (Cth) or allowed by this copyright notice, all other rights are reserved, including (but not limited to) all commercial rights. Requests and inquiries concerning reproduction and other rights to use are to be sent to the Communication Branch, Department of Health, GPO Box 9848, Canberra ACT 2601, or via e-mail to copyright@health.gov.au. First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-25 ii
Foreword The First National Blood Borne Viruses (BBV) The National Strategies recognise the and Sexually Transmissible Infections (STI) considerable work already being progressed Research Strategy 2021-2025 will ensure that collaboratively by governments, community- future funded research activities best align based organisations, researchers, health with the priorities of the BBV and STI professionals and communities. The success research agenda, and support measurable of the National Strategies relies on continuing progress towards the goals and targets of the to build a strong evidence base to better five National BBV and STI Strategies. inform our responses, evaluating our Importantly, BBV and STI research will help approaches to identify what is most effective, to focus actions that improve the quality of life and further strengthening our workforce, for people living with BBV and/or STI, and partnerships and connections to priority address barriers to services and supports that populations. There is a critical need to affect health seeking behaviours. improve knowledge and awareness of BBV and STI to identify emerging issues and The First National BBV and STI Research challenges. Maintaining our momentum is Strategy will capitalise on the significant essential – we now have the potential to progress that has been made in recent years considerably advance our response across in our responses to BBV and STI. This some critical areas and inform future includes the listing of pre-exposure health policy. prophylaxis for HIV prevention, additional HIV treatments, and ensuring the broadest The development of the First National BBV possible access to direct acting antiviral and STI Research Strategy has highlighted treatments for hepatitis C on the the significant collegiality and commitment of Pharmaceutical Benefits Scheme. Despite all stakeholders to strengthen our BBV and this progress, BBV and STI remain significant STI response. With this foundation, Australia public health issues. can continue to strive to achieve great things, and build on our reputation as a world-leader in both research and practice. The Hon Greg Hunt MP Minister for Health and Aged Care
Contents 1. Introduction .................................................................................. 3 2. The Strategy ................................................................................. 6 3. Guiding Principles ........................................................................ 7 4. Opportunities and Benefits ....................................................... 13 5. Key Areas for Action .................................................................. 14 6. Governance and Implementation .............................................. 15 First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-25 2
1. Introduction The five National Blood Borne Viruses (BBV) evaluation, innovation, and use of data to and Sexually Transmissible Infections (STI) develop and implement integrated, Strategies1 set the direction for Australia’s evidence-based health policies. continuing response, and represent the Responses to BBV and STI have been commitment of Australian governments, underpinned and strengthened by a researchers and health and community partnership approach between the Australian organisations to address the impact of BBV and state and territory governments, and STI on the Australian community. community organisations, researchers, health The First Blood Borne Viruses and Sexually professionals, people at risk of, living with Transmissible Infections Research Strategy and/or affected by BBV and STI. Supported 2021 –-2025 (the Strategy) aims to support by continued investment from governments, nationally relevant research and innovation, high quality and rigorous research conducted and capacity building in reducing the by the national centres of research excellence incidence and impact of BBV and STI in and other organisations is critical to Australia. The Strategy builds on the Australia’s robust response to BBV and STI. considerable work already being progressed collaboratively by governments, community- The ambitious targets and goals outlined in based organisations, researchers, health the five National Strategies (the National professionals and communities to improve Strategies) will continue to guide Australia’s health outcomes for people at risk of, and efforts to significantly reduce the transmission living with, BBV and STI. of BBV and STI, increase rates of diagnosis, and improve access to prevention, harm Australia supports the World Health reduction, treatment and care services. The Organization’s (WHO) Global Health Sector National Strategies also include guiding Strategies on Sexually Transmissible principles to support a high quality, evidence- Infections, HIV and Viral Hepatitis 2016–21, based and equitable response to BBV and which have an overarching goal of eliminating STI. They are drawn from Australia’s efforts BBV and STI as a public health concern by over time to respond to the challenges, 2030. Meeting and exceeding the international threats and impacts of hepatitis B, hepatitis C, obligations and targets is a critical part of HIV, and STI. Importantly, they also focus on Australia’s response. improving the quality of life for people living The Australian Government supports health with BBV and STI, addressing the barriers to and medical research through increased services and supports that affect health investment and work to strengthen safety and seeking behaviours and overall access. quality across the health system to reduce risks to patients and generate efficiencies. This aims to ensure Australia’s health system is better equipped to meet current and future health needs by applying research, 1 Third National Hepatitis B Strategy 2018-2022 Fifth National Aboriginal and Torres Strait Islander Fourth National STI Strategy 2018-2022 BBV and STI Strategy 2018-2022 Fifth National Hepatitis C Strategy 2018-2022 Eighth National HIV Strategy 2018-2022
This includes stigma and discrimination support a comprehensive understanding of experienced by marginalised and priority BBV and STI in Australia. This includes populations including: understanding the social drivers that influence Aboriginal and Torres Strait Islander the rates of and responses to BBV and STI, people evaluating surveillance data to monitor the culturally and linguistically diverse impact of prevention interventions and harm populations reduction approaches, and identifying trends people who inject drugs and/or living of concern and gaps in the current response. with HIV, hepatitis B and/or hepatitis C Conducting independent research to inform, sex workers improve and monitor government policy is a gay men and other men who have sex challenge for both policy makers and with men researchers alike. The use of research in trans and gender diverse populations policy development can be encouraged by people in custodial settings or history enabling timely access to relevant data and of incarceration. research findings, encouraging interaction between policy makers, healthcare providers, Significance of BBV and researchers, affected communities and STI Research consumers, and increasing individual and organisational capacity to use research. Australia has continued to make significant The Ottawa Charter for Health Promotion progress in the prevention and management provides the framework for effective actions of BBV and STI. However, diseases like under this Strategy. It facilitates the active hepatitis B, hepatitis C, HIV, syphilis, participation of affected communities and gonorrhoea, human papilloma virus (HPV) individuals to increase their influence over the and other sexually transmissible infections determinants of their health, and the remain significant public health issues. formulation and application of laws and public Persistent and emerging issues, such as anti- policies to support and encourage healthy microbial resistance among key STI and behaviours and respect for human rights. human T-cell lymphotropic virus type 1 The Australian and international community (HTLV-1) also require an ongoing and expects research to be conducted concerted effort. responsibly, ethically and with integrity. Social, behavioural, epidemiological and The Australian Code for the Responsible clinical research is important in developing Conduct of Research articulates the broad a strong evidence base for managing and principles that characterise an honest, ethical preventing BBV and STI in the community. and conscientious research culture. It Research is an essential part of the health establishes a framework for responsible system, spanning a pipeline from concept to research conduct that provides a foundation laboratory through to translational and for high-quality research, credibility and implementation research, clinical and social community trust in the research endeavour. application, and community benefit. Policy relevant research needs to be responsive to changing evidence and emerging issues and be aligned to support the delivery of government’s strategic goals. Continuous improvement of data collection and systems is also important to better First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-25 4
Close collaborations between research agencies and funders, such as government and knowledge users2, have been shown to be effective in generating policy-relevant research, particularly where funders are involved in decisions that drive the strategic directions of the program to deliver on priority outcomes. Partnerships between researchers, health professionals, and community and peer-led organisations are essential and valuable. Such organisations are often the first to identify cultural influences, social interactions, demographics of priority populations, and changes in behaviours due to their direct contact with affected communities and are therefore critical to a research-driven targeted response. The Australian Medical Research and Innovation Strategy 2016–2022 identifies and articulates a number of challenges facing the health and medical research sector in Australia, including the BBV and STI landscape. These challenges need to be addressed, through applied and social research, to reduce the morbidity, mortality and impact of disease, and in turn lift and accelerate the social, health and economic gains to be made from research at individual and population levels. 2 knowledge user is defined as an individual who is likely trainee, health practitioner, policy maker, educator, to use knowledge generated from research to make decision maker, health care administrator, national peak informed decisions about health research, health organisation, community organisation, person living with policies, programs and/or practices. A knowledge user or at risk of BBV and STI and affected community, can be, but is not limited to, a researcher, research private sector organisation, or media outlet. First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-25 5
2. The Strategy The Strategy sets out the aims and Objectives objectives of the multi-disciplinary research activities undertaken within Embed and foster research and Australia and supports the innovative program design that directly addresses and implements goals and implementation of the five National targets in the five National BBV and STI BBV and STI Strategies by identifying Strategies. challenges, barriers and Generate a holistic evidence base, opportunities to achieve the agreed informed by multi-disciplinary research, goals and targets. The Strategy also to guide policy development and co- identifies a series of Guiding designed health promotion, prevention Principles that have the potential to strategies, and health services and advance the BBV and STI policy programs. landscape and increase the Address gaps in data and knowledge to community use of research, creating identify emerging issues and greater impacts on prevention and challenges, and inform future priorities, meet new challenges and develop diagnosis of infections, treatment and effective health policy. care of people living with infection. It Drive collaboration and linkage across will also address social barriers i.e. research programs, and encourage stigma and discrimination, thereby future adoption of research outcomes in improving health outcomes both now policy and practice. and into the future. Support a continuum of service delivery The Strategy builds on the substantial (i.e. Community and peer-led prevention advances that have been made in BBV and interventions, diagnosis, treatment, care STI research programs over the last 20-30 and social support services) to years, through sustained investments made maximise impact and improve by Australian governments, in research population health outcomes. conducted by National Centres of Research Improve the impact of BBV and STI Excellence and other organisations. research to inform effective social and health policies and programs. Aim To guide BBV and STI research and innovation to effectively inform the implementation of priority actions outlined in the five National BBV and STI Strategies, focused on reducing morbidity, mortality, stigma and discrimination, increasing access to new biomedical interventions and improving quality of life and health outcomes for people living with, or at risk of, BBV and STI. First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-25 6
3. Guiding Principles The four guiding principles provide a There have been a number of advances in the framework for identifying BBV and prevention and treatment of BBV and STI in STI research priorities: recent years. Some of note are: 1. Translation: focus on translation and the advent of and unrestricted access to implementation of research and new direct acting antivirals (DAA) for innovation in the BBV and STI landscape curative treatment of hepatitis C and to reform services and systems. methods for monitoring antiviral resistance 2. Data and infrastructure: build on the strong evidence-base to identify and the widespread availability of address gaps in knowledge and integrate antiretroviral drugs to reduce the risk of BBV and STI translational, transmission and prevent acquisition of epidemiological, behavioural, clinical and HIV social research to inform future health access to and successful rollout of a policies and programs, and ensure highly efficacious vaccine for managing linkage and alignment with priority areas the prevalence and prevention of of action. hepatitis B, particularly improving uptake 3. Health services and systems: to among Aboriginal and Torres Strait discover, trial and evaluate innovative Islander people and sustainable models of healthcare to point-of-care tests for HIV, hepatitis C support the continuum of prevention and STI, which have been instrumental interventions and care services for people in providing same-day testing and at risk of or living with BBV and STI. treatment for vulnerable and 4. Capacity and collaboration: encourage marginalised populations collaboration between researchers, dried blood spot testing for HIV and research centres, health providers, hepatitis C, allowing self-testing among community partners and peer-led target populations organisations, and the introduction of Gardisal®9, which key stakeholders focusing on policy and protects against nine types of human practice solutions. papilloma virus the use of pathogen genomics and Translation molecular epidemiology to enhance the The elimination of BBV and STI as a public public health response. health concern requires new technologies and High-quality research from a broad range of innovative approaches informed by up-to-date perspectives (clinical, epidemiological, social, research and evaluation. It also requires and behavioural), has guided the effective engagement with affected persons development and implementation of these and their communities to address advances. However, there is scope for further longstanding disparities and issues such as research and innovation in practice to support stigma and discrimination, the current lack of the optimal adoption and scale-up by treatment and prevention activities in custodial identifying novel ways to engage the BBV and settings, and challenges in connecting with STI affected communities and remove barriers marginalised and priority populations. to diagnosis, testing and treatment uptake. First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-2025 7
Ongoing research and innovation is required and STI control and prevention is the lack of along the entire continuum of BBV and STI reliable, low-cost, point-of-care tests, prevention, education, health promotion, particularly in rural and remote communities, diagnosis, and treatment, cure and care and access to safe and effective self-tests. services. This includes research that supports Research is measured as having impact when targeting, simplifying and adapting services research findings are translated and and programs with community needs, implemented to inform, drive and evaluate removing barriers to accessing care, and effective social policies and health programs. supporting entry into care and retention. Most health systems are faced with high Innovation is not only required to develop new demand but have a limited budget with which technologies, interventions, improved models to provide the necessary services. A cost- of care and other approaches, but is also a effectiveness analysis can help determine the key to nationwide scale-up of existing best use of limited funds available to promote interventions proven to be effective and to use health, optimise prevention interventions and existing tools more efficiently; adapting them care to maximise value for money. for different populations, settings and Transforming and communicating the purpose purposes. Research that delivers new and role of BBV and STI research and methods to avoid wasteful interventions, effectively marketing its products and services adopts best practice and fosters information to target marginalised and priority populations, exchange will allow community organisations including through knowledge translation will and clinicians to benchmark with peers and lead to positive clinical behavioural and lead to continuous quality improvement. This societal changes. includes the importance of data analyses, mathematical modelling and health economics Data and Infrastructure research and assessment of the efficiency of The National BBV and STI Strategies are interventions at delivering outcomes. critical in guiding Australia’s ongoing health Innovation in new diagnostics, prevention sector and community response, significantly interventions, vaccines and curative reducing the transmission of BBV and STI, treatments for BBV and STI will enhance improving clinical management, and reducing impact and lead to improved health outcomes the impact of infection, stigma and for people living with at risk of, or living with discrimination. The costs of these BBV and STI. Despite the major advances in interventions are assumed to be shared the safety, potency and acceptability of across different parts of the health sector. medicines and regimens, a number of areas However, the total costs of implementation to remain where improvements are required and achieve the goals and targets set out in the possible. For example, the current approach five National Strategies are unknown. to treatment for chronic hepatitis B infection is Costing data, drawn from research across complex, reflecting a risk-benefit approach demographic and population estimates, driven by the lack of an effective curative including the costs of stigma, discrimination, regimen. Also, while the advent of direct- human rights and legal issues, must be acting anti-virals that cure hepatitis C reviewed and an evaluation of future costs infections has been highly successful, there provided to Government. This will help inform remains an urgent need for a prophylactic and build on the existing evidence-base, and vaccine for the prevention of HIV and hepatitis translate research and costing data into future C, to help reach elimination targets set by the investments from different levels of WHO in Australia and globally. Additionally, government in the BBV and STI landscape. one of the major barriers to advancing BBV First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-25 8
Continuous improvement of data collections disaggregated to the regional, and systems is important to support a community and facility levels by age, comprehensive understanding of BBV and sex, population and location to better STI in Australia. Cost-effective and systematic understand subnational epidemics, solutions, including the better use of existing assess performance along the data linkage resources, are required to continuum of BBV and STI services facilitate continued improvement in the and guide more focused investments completeness of reporting and accuracy of and services estimates for notifiable BBV and STI in improve reporting of Aboriginal and Australia. This will build on the strong Torres Strait Islander status in clinical evidence-base, and the ongoing surveillance and pathological settings i.e. all relevant and monitoring frameworks that are used to data and administrative collections integrate BBV and STI data to support including pathology request forms, healthcare delivery, service improvement laboratory results and disease and best practice. notifications. Accurate data that are easily accessible in a An integrated national data framework, linking timely fashion are critical to responsive and providing access to clinician and research. This Strategy will support community captured data and surveillance development and application of new information, will improve the effectiveness, methodologies and opportunities for the efficiency, and quality and safety of clinical research and analysis of factors that lead to service delivery to people living with BBV and the transmission of BBV and STI as well as STI and yield benefits for consumers, the the testing and evaluation of policies and community and the broader health system. It interventions to improve health outcomes. will also allow a more accurate assessment of Specialised research methods capable of the cascades of care, and evaluation of the collecting meaningful data about population quality of monitoring and care provided to groups that are often too small to be visible in people living with BBV and STI. population datasets are needed to understand This research will not only address gaps in community and cultural drivers of BBV and existing data but will also identify, examine STI transmission and opportunities for and evaluate key changes in the epidemiology prevention and enhanced intervention of BBV and STI within priority populations, engagement at the local level. emerging issues and concerns and influences This includes research to: on people’s decisions with respect to risk identify gaps in policy and practice, and taking and seeking testing, treatment deliver tools to inform, monitor and and care. evaluate population health responses to BBV and STI. There is a need to Any data and infrastructure improvements, improve the timeliness and consistency however, will need to adhere to the National Statement on Ethical Conduct in Human of data and knowledge at the national and state and territory levels to better Research (2007) and best practice support completeness and comparability governance along with the jurisdictional guidelines on cultural security and improve the level of detail and competency. granularity of collected data to better identify trends and issues of concern in relation to specific priority and sub- populations. Data, where ethically permissible, should be appropriately First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-25 9
Social research plays a significant role in The inclusion of primary care and affected investigating the experiences and needs of communities in this research is of utmost priority populations, and supports the importance to encourage well-designed, targeting and outreach of services and culturally appropriate and impactful health programs. Responding to the BBV and STI and social outcomes. epidemics requires an in-depth understanding Research is also not complete until the results of where, when, how and among whom new and findings are reported back to community infections are occurring. This includes groups and key stakeholders involved in the identifying the social, cultural and structural research. Ideally a partnership approach factors that facilitate transmission of BBV and should be taken from the conceptualisation STI, and individual and community needs and stage of research, with meaningful preferences in terms of access to and use of consultation and collaboration prioritised relevant services. Prevention interventions, throughout the research timeline. Participants treatment and care programs can then be should also have access to the data collected prioritised and focused accordingly. and be empowered to apply the research A robust strategic and research led findings and recommendations. Strengthening information system that analyses and research translation to guide interventions at translates up-to-date research data on BBV the local and national level will better support and STI into usable information can leverage the primary care and community sector much needed political commitment. It will also workforce and ensure equitable and create awareness and advocate for action appropriate access to care and services. and resources, to set national targets, plan A cascade analyses of different populations for a focused response, and implement and settings for BBV and STI to determine the programs most efficiently in order to quality of services, service utilisation and achieve greatest impact. acceptability will identify gaps and weaknesses in care services, inform possible Health services and systems remedial actions and help assess the effect of The National BBV and STI Strategies include interventions, care and management. More priority areas for action designed to support broadly, research into the social context of the the achievement of goals and targets. lives of service users and those not engaged Achievement of the WHO 2030 global health in care, investigating the specific experiences targets requires a robust and flexible health and needs of marginalised and vulnerable system with accessible and effective service populations will provide insight into effective delivery models, and timely access to models of engagement. For example, accurate health information. People living with research indicates that greater integration and BBV and STI must receive the full range of linkage of BBV and STI primary care services relevant health services they need along with with other relevant health services (broader the prevention initiatives, both within the sexual and reproductive health, harm community and in correctional facilities. reduction and alcohol and other drug use disorders, blood safety, cancer prevention and Research must be focused on discovering management, and non-communicable innovative and sustainable community- diseases including mental health services) centred models of service delivery, and can speed up progress towards key identifying opportunities to improve patient milestones and targets and increase management systems with a view to efficiency, access, acceptability encounter future challenges, as well as and savings. future costs and benefits. First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-25 10
Identifying the best methods and approaches Research can sometimes be perceived as an for delivering the continuum of BBV and STI imposition on communities and resources services to different populations and in rather than as a means to reduce risk, different locations, will help achieve equity, increase access and service delivery, and ensure access to quality, and culturally improve health outcomes. It is important to appropriate services, remove barriers to develop and foster a research culture in BBV service access and maximise impact. and STI across Australia that embeds A dynamic and informed community research outputs as core business in strategic engagement mechanism in BBV and STI planning, policy, capacity building and research, particularly with priority populations, workforce development strategies. Research will also address stigma and discrimination activities must be valued and recognised as and minimise the impact on the health of high quality and serving community needs. people at risk of or living with BBV and STI. This will strengthen and enhance research literacy to enable and support national and Overall health impact is boosted when service international collaborations, which will in turn delivery approaches fit the realities and needs facilitate research translation to benefit of consumers (especially marginalised and research participants. priority populations) and end users, explore opportunity costs and minimise inefficiencies, The success of BBV and STI research use simplified and standard protocols, and depends largely on workforce capacity and fully engage communities. There are talent. Building research and workforce opportunities for further research and capacity includes enhancing the abilities of innovation in all those respects. individuals, organisations and systems to undertake and disseminate high quality Capacity and Collaboration research efficiently and effectively, and the capacity of other sectors and stakeholders to The Australian Government encourages engage with research and utilise knowledge research whereby researchers, community derived from this process. In Australia, organisations, affected communities and workforce capacity in BBV and STI research policy makers are meaningfully involved in all has been built through long-term investments stages of research priority setting and co- by governments in research centres so that design – from development to application, skills, knowledge and mentorship occurs, and building an understanding of the way relationships are built across communities evidence is generated to allow for greater and research centres rather than just integration between research and the use of individual researchers. This has been core to evidence. Collaborative BBV and STI successful community-engaged research in research can guide and respond to future BBV and STI prevention, treatment and care health policy and programs. A strong and over many decades. concerted approach increases the likelihood that research will be timely, co-produced, BBV and STI responses in recent years, in policy aligned and applied in practice to Australia and globally, have utilised research improve lives and outcomes. This breakthroughs in basic science and collaboration can occur at inter- and intra- technologies, and demonstrated that it is government levels, within primary care feasible to scale-up clinical and public health settings, health services, community programs in challenging settings. organisations and research centres, and incorporate meaningful community partnerships and consultation. First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-25 11
It is vital that research be undertaken in partnership with community-based organisations and service providers, and that a partnership approach is always taken in identifying and pursuing research priorities. Research collaboration with affected communities must continue, with the intent to stimulate innovation and effectiveness, as this is crucial to achieve targets and improved health and well-being outcomes. This includes social, behavioural, clinical and structural drivers for and barriers to achieving optimal health outcomes across areas of social impact such as sexual and reproductive health, harm reduction, drug and alcohol use disorders, sex work, mobility and migration, stigma and discrimination, particularly for marginalised and vulnerable population groups. Research training and skills development should also be integral to the education of all health service providers. Infectious disease modelling, discovery, development, and commercialisation of research cannot occur without appropriate workforce capacity, effective implementation and a means to evaluate the impact this work has on quality of life for people living with or at risk of BBV and STI and the wider community. The Government is willing to maximise ongoing and effective partnerships and shared goals amongst levels of government, national peak organisations, the clinical workforce, researchers, affected communities and all funding bodies. Through collaboration, researchers can be encouraged to adopt entrepreneurial approaches, test the implementation of science applications, and look for opportunities to deliver tools to inform, monitor and evaluate the population health responses in Australia. First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-25 12
4. Opportunities and Benefits Research is vital in both supporting The Australian Medical Research and the health system and community- Innovation Strategy 2016–2021 notes that an based organisations towards a improvement in health and well-being provides additional benefits to the economy tailored BBV and STI response. While and to society. It: research is sometimes invisible to the enhances productivity gains by larger community on the frontline of avoidance of premature mortality care, these activities are often and morbidity operating behind the scenes to make reduces care, carer and aids costs a difference in the type, quality and reduces loss associated with effectiveness of health services, and government transfers such as taxation the care delivered. revenue forgone and welfare and The National BBV and STI Strategies have disability payments. capitalised on the significant headway in Targeted BBV and STI research will enable technological advances, testing, care and researchers to answer questions about the treatment approaches that have been made in causes, prevention, treatment, management recent years in response to BBV and STI. The and minimisation of impact of disease. In National Strategies for many years have also doing so, it will also provide comprehensive prioritised high quality and innovative advice to governments, both at the translational, epidemiologic and social Commonwealth and state and territory levels, research that has enabled us to understand to provide certainty for research funding and cultural and behavioural drivers of BBV and longer-term investment in this sector to STI transmission, testing and treatment ensure improved outcomes. Long-term uptake and engagement in care. Despite investment in BBV and STI research also has efforts, the National Strategies identify trends the potential to benefit the quality of research of concern and gaps in the response. It is by retaining research expertise and engaging critically important to continue to build on the communities in a sustained manner. strong evidence base for effectively Collaborative efforts between communities, responding to existing and emerging BBV organisations, researchers and health and STI issues and challenges. professionals offer opportunities to combine Maintaining a strong multi-disciplinary the strengths of all partners to identify research agenda to inform and support the research priorities of most value to implementation of the National BBV and STI communities, policy and practice. Strategies is essential. First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-2025 13
5. Key Areas for Action This Strategy provides direction for understand and address the barriers to researchers to define, innovate and services and support that affect health accelerate the existing BBV and STI seeking behaviours and overall access, e.g. stigma and discrimination research agenda, requiring the experienced by marginalised and research community to break new priority populations ground to: promote dynamic and informed support research that directly addresses community engagement in BBV and the National Strategies targets and STI research, particularly that of uses process and impact evaluation priority populations for validation encourage pioneering methods of address knowledge gaps to build the evaluation, and research that validate evidence base to inform future priorities improved clinical testing and treatment for health policies and programs, and efficacy, leading to improved mortality ensure linkage and alignment with rates, and quality of life outcomes priority areas of action address gaps in research literacy evaluate processes and impacts to among the BBV and STI sector validate proactive and new approaches workforce and support research to BBV and STI prevention, treatment, translation. care, education and health promotion. ------------------- -------------------- ensure equitable and effective treatment deliver new methodologies and curative in all health service contexts, treatments, use existing tools more recognising the dignity of all, and the efficiently, and to adapt them for right and responsibility of individuals to different populations, settings own and participate in the achievement and purposes of their own health goals and outcomes encourage translational research aimed at preventing and eradicating BBV understand the social contexts that and STI shape or influence health related practice and healthcare engagement evaluate the efficiency and affordability of interventions including cost- -------------------- effectiveness analysis, return on strengthen ongoing effective investment and budget impact partnerships and shared goals amongst assessment through health governments, community sectors, peak economics research. organisations, researchers, the ---------------------- workforce, communities and all funding bodies. First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-2025 14
6. Governance and Implementation The research and evaluation Research entities make a valuable underpinning the BBV and STI contribution to the promulgation of evidence- service environment over many years based policy. This Strategy defines the process for validating the benefit of funded has ensured substantial progress in research towards the implementation of the clinical, personal and social National BBV and STI Strategies and ensures responses to key issues. This has that research funded by the Commonwealth resulted in greater clinical testing and supports the aims, objectives and targets of treatment efficacy, population-level the current National Strategies, and beyond. effectiveness, more socially informed Grants are widely used to achieve discourse towards addressing issues government policy outcomes that support such as stigma and discrimination, Australia’s jobs, growth and innovation. The and increased personal Commonwealth Grants Rules and Guidelines empowerment. (CGRGs) establish the whole-of-Government grants policy framework, under which non- The research pathway must follow a targeted corporate Commonwealth entities undertake approach to improve the availability, grants administration. The CGRGs contain appropriateness, effectiveness, efficiency, key legislative and policy requirements, and quality and safety of service delivery to yield explain the better practice principles of substantial benefits for consumers, the grants administration. community and the health system – one from which future generations will benefit. The seven key principles for grants The Australian Government is committed to administration that apply to the grants lifecycle providing strong leadership by working across and all grant opportunities are: portfolios, jurisdictions and key stakeholders robust planning and design including community-based organisations to collaboration and partnership achieve the goals of the National Strategies. proportionality The Australian Government Department of Health will ensure that the BBV and STI an outcomes orientation research agenda remains responsive and achieving value with relevant money transparent and promote translation of governance and accountability research outputs into evidence-based policy probity and transparency and practice. Ensuring that the requirements of the CGRGs The Strategy also recognises the are understood and effectively incorporated considerable work already being progressed will ensure that potential grantees best suited and encourages flexibility on how research to undertake grant activities apply for and funds are distributed by Government. This can receive a grant. This will facilitate the occur via an approach to market to undertake achievement of outcomes that align with the a limited or open tender process, by an targets and priority areas for action in the independent expert selection process, or by National BBV and STI Strategies. direct funding to any eligible organisation. First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-2025 15
The success of this Strategy is contingent on productive partnerships between Commonwealth, state and territory governments, community-based organisations, health professionals and researchers. Evaluation of effective research programs and policies will also provide a more definitive evidence base and inform the development of subsequent National BBV and STI Strategies. It also aims to enhance the conduct and use of research to advance the BBV and STI policy landscape, thus creating greater impacts on BBV and STI outcomes, both now, and into the future. This will further reduce the rates of morbidity and mortality that impact affected communities and the health system. The Strategy will be reviewed in 2025, to align with the National BBV and STI Strategies, and ensure alignment with identified goals and targets. With this foundation, Australia can continue to achieve great things, building on its reputation as a world-leading model of best practice, particularly in BBV and STI research and innovation. First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-25 16
For more information go to health.gov.au First National Blood Borne Viruses and Sexually Transmissible Infections Research Strategy 2021-2025 17
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