Medtech (Overweight) Aesthetic devices market: Spotlight on innovation

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Medtech (Overweight) Aesthetic devices market: Spotlight on innovation
Industry Report | May 24, 2021

  Medtech (Overweight)
  Aesthetic devices market: Spotlight on innovation

  Choong-hyun Kim, CFA choonghyun.kim@miraeasset.com

Analysts who prepared this report are registered as research analysts in Korea but not in any other jurisdiction, including the U.S.
PLEASE SEE ANALYST CERTIFICATIONS AND IMPORTANT DISCLOSURES & DISCLAIMERS IN APPENDIX 1 AT THE END OF REPORT.
Medtech (Overweight) Aesthetic devices market: Spotlight on innovation
Contents

   I.   Key drivers: Vaccination and innovation                    3

   II. Minimally invasive: Energy-based devices leading the way    5

   III. Invasive: Innovations in breast implant market            11

   IV. Domestic market trends                                     17

   V.   Top pick: Classys                                         19

2 | Medtech                                                            Mirae Asset Securities Research
Medtech (Overweight) Aesthetic devices market: Spotlight on innovation
I. Key drivers: Vaccination and innovation
COVID-19 vaccination                               •   Vaccination rates are picking up globally.
status                                             •   In parts of the world where vaccination is well underway, new COVID-19 cases are falling.
                                                   •   The US CDC lifted the mask mandate for vaccinated residents in both indoor and outdoor settings.
                                                   •   Some countries are showing signs of a post-pandemic economic recovery.

 Share of people who have received at least one COVID-19
                                                                                               Cumulative confirmed COVID-19 cases by country (log scale)
 vaccine dose

Source: Our World in Data, Mirae Asset Securities Research                                    Source: Our World in Data, Mirae Asset Securities Research

3 | Medtech                                                                                                                                                Mirae Asset Securities Research
Medtech (Overweight) Aesthetic devices market: Spotlight on innovation
I. Key drivers: Vaccination and innovation
Innovation lifting stocks                            •   Returns from bottom: +907% for Establishment Labs, +527% for InMode, +414% for Cutera, +217% for Lutronic,
                                                         +103% for Classys
to new heights
                                                     •   Earnings have recovered on the reopening of aesthetic and dermatology clinics amid ongoing vaccinations.
                                                     •   2021F revenue growth guidance: +31-36% for InMode, +39-44% for Establishment Labs, +30% for Lutronic
                                                     •   Companies with innovative technologies have seen particularly strong share performances and revenue growth.
                                                     •   Given that some pandemic restrictions still remain in place, we expect top-line growth to accelerate further as the
                                                         post-pandemic recovery gains momentum.
                                                     •   With the aesthetic devices market anticipated to continue robust growth, we think innovative companies merit
                                                         special attention.

 Global energy-based aesthetic device makers: Market cap changes                                Global energy-based aesthetic device makers: Revenue growth

  (8/7/19=100)                                                                                  (%)                     InMode                          Establishment Labs
 350                Classys                         Lutronic                                    130                     Cutera                          Lutronic
                    Establishment Labs              Cutera                                                              Classys
                    InMode
 300                                                                                            110

                                                                                                90
 250                                                                                                                                                Global COVID-19
                                                                                                70                                                      spread
                      Global
 200
                  COVID-19 spread                                                               50

 150                                                                                            30

                                                                                                10
 100
                                                                                                -10
  50
                                                                                                -30

   0                                                                                            -50
       1/20                        7/20                           1/21                                2Q18         4Q18           2Q19       4Q19         2Q20         4Q20     2Q21F

Source Bloomberg, Mirae Asset Securities Research                                              Source: Bloomberg, Mirae Asset Securities Research

4 | Medtech                                                                                                                                              Mirae Asset Securities Research
Medtech (Overweight) Aesthetic devices market: Spotlight on innovation
II. Minimally invasive: Energy-based devices leading the way
Global energy-based                               •   Interest in aesthetic treatments is growing in line with rising income levels and standard of living improvements.

aesthetic devices market                          •   In particular, energy-based aesthetic devices—radiofrequency (RF)-based, ultrasound-based, laser-based, etc.—
                                                      have increased in popularity, as they enable minimally invasive procedures.
to grow at CAGR of 10%                            •   Energy-based aesthetic devices have the following advantages:
                                                      1) Diverse treatment/care options (tattoo removal, hyperpigmentation treatment, body contouring, skin
                                                         tightening, blood vessel removal, etc.)
                                                      2) Non-surgical, minimally invasive procedures; as effective as surgeries for certain indications
                                                      3) Combination therapy (e.g., Ulthera + Thermage, facial contouring injections + Shurink, etc.)
                                                  •   Between 2021 and 2025, the global energy-based aesthetic devices market is projected to grow from W4-5tr to
                                                      US$7.3bn (10% CAGR).

 Energy-based aesthetic devices: Applications                                                Global energy-based aesthetic devices: Market size and forecasts

Source: Cutera, Mirae Asset Securities Research                                             Source: Lutronic, Mirae Asset Securities Research

5 | Medtech                                                                                                                                     Mirae Asset Securities Research
Medtech (Overweight) Aesthetic devices market: Spotlight on innovation
II. Minimally invasive: Energy-based devices leading the way

1980s to mid-2000s:                                   •   The earliest technologies to emerge and gain acceptance were laser devices and intense pulsed light (IPL)
                                                          therapy for peeling, pigmentation treatments, hair removal, photorejuvenation, etc. Market leaders at the time
Laser devices lead                                        were Cynosure, Cutera, Candela, and Lumenis.
market growth                                         •   Laser devices remain the most basic tool in dermatology clinics’ treatment arsenal, with over 40mn such
                                                          procedures performed annually around the globe.
                                                      •   As relevant patents have mostly expired, competition has intensified.
                                                      •   This situation has created opportunities for second-tier competitors, while encouraging incumbents to diversify
                                                          their product portfolios to other energy-based aesthetic devices.

 Revenue comparison of top four players                                                          Low/medium-end device makers catching up with top-tier players

(US$mn)                                                                                         (US$mn)                                                                             (x)
800               Cynosure                                                                      200                       Cutera (L)                                                 4
                  Syneron Candela
                  Lumenis                                                                                                 Lutronic (L)
                                                                                                180
700               Cutera                                                                                                  Cutera/Lutronic (R)
                                                                                                160
600                                                                                                                                                                                 3
                                                                                                140
500
                                                                                                120

400                                                                                             100                                                                                 2

                                                                                                 80
300
                                                                                                 60
200                                                                                                                                                                                 1
                                                                                                 40
100
                                                                                                 20

  0                                                                                                0                                                                                0
         02    03     04     05     06    07     08       09   10   11   12   13   14                    08          10             12          14      16         18          20
Source: Edgar, Mirae Asset Securities Research                                                  Source: Company data, Mirae Asset Securities Research

6 | Medtech                                                                                                                                             Mirae Asset Securities Research
Medtech (Overweight) Aesthetic devices market: Spotlight on innovation
II. Minimally invasive: Energy-based devices leading the way
Mid-2000s onward:                               •   Since the early/mid-2000s, aesthetic devices using a variety of energy types, such as RF (e.g., Solta Medical’s
                                                    Thermage), ultrasound, and cryolipolysis, have been developed.
Development of various
                                                •   Laser energy can penetrate the skin surface and upper dermis, while RF and ultrasound can reach deeper skin
energy-based aesthetic                              layers (lower dermis and fascia, respectively).
devices  Birth of body                         •   Due to the introduction of these new devices, surgical procedures such as facelifts and liposuction are
                                                    increasingly being replaced by non-surgical procedures such as body contouring and skin tightening.
contouring/skin                                 •   New entrants Solta Medical, Zeltiq, and Ulthera drove innovation.  Premium procedures using their products
tightening market                                   are now are widely performed.

                                                                                            Global financial crisis created opportunities for innovative companies
 Energy-based aesthetic devices: Energy types and targeted skin layers
                                                                                            To catch up with incumbents
                                                                                            (US$mn)                                                                             (x)
                                                                                            800                   Big 4 incumbents (L)                                         10
                                                                                                                  New players (L)
                                                                                                                                                                               9
                                                                                            700                   Incumbents/new players (R)
                                                                                                                                                                               8
                                                                                            600
                                                                                                                                                                               7
                                                                                            500
                                                                                                                                                                               6

                                                                                            400                                                                                5

                                                                                                                                                                               4
                                                                                            300
                                                                                                                                                                               3
                                                                                            200
                                                                                                                                                                               2
                                                                                            100
                                                                                                                                                                               1

                                                                                              0                                                                                0
                                                                                                    03            05            07             09       11         13

Source: Merz, Mirae Asset Securities Research                                              Source: Merz, Mirae Asset Securities Research

7 | Medtech                                                                                                                                         Mirae Asset Securities Research
Medtech (Overweight) Aesthetic devices market: Spotlight on innovation
II. Minimally invasive: Energy-based devices leading the way
Comparison of facelift procedures

                                                                                                                                                               High-intensity focused
                                   Surgery                 Hyaluronic acid filler injection              Thread lift                       RF
                                                                                                                                                                 ultrasound (HIFU)

                                                                                                                         RF energy is applied to the         HIFU is applied to the skin's
                                                            Dermal filler is injected into     Dissolvable threads are  skin's deeper layers, causing          deeper layers, causing
                        Skin is surgically removed
Procedure                                                  the lines, folds, and tissues of inserted underneath the skin collagen contraction and             collagen contraction and
                            and repositioned
                                                                       the face                   to lift sagging skin    stimulating new collagen            stimulating new collagen
                                                                                                                                 production                          production

Degree of
                                  Invasive                       Minimally invasive                  Minimally invasive               Non-invasive                  Non-invasive
invasiveness
                                                          Nasolabial folds, tear troughs,           Jawline, cheekbone,
Treatment area                       Face                                                                                              Face, neck                     Face, neck
                                                                 forehead lines                       marionette lines
Interval between
                                   One time                             One year                    Six months to one year     Three months to one year      Three months to one year
procedures

Procedure time                Three-four hours                         30 minutes                        30 minutes                  15-20 minutes                 15-20 minutes

                                                                                                                                 Takes several weeks for        Takes several weeks for
                                                                                                                               tightening results to show;    tightening results to show;
                                                                                               Recovery takes time; does not
                            Recovery takes time;                                                                             relatively frequent treatments relatively frequent treatments
Cons                                                                 Partial lifting            last as long as surgery and       required; possible skin
                      limited target customer base                                                                                                               required; possible skin
                                                                                                       filler injections         damage; pain (numbing     damage; pain (numbing cream
                                                                                                                                 cream may be needed)
                                                                                                                                                                    may be needed)

Price
                                  W2-5mn                            W200-250,000                       W500-600,000                     W1.9mn                        W1-1.2mn
(global brand)

Price
                                  W2-5mn                            W100-140,000                       W100-200,000                  W250-300,000                  W250-300,000
(domestic brand)

Notes: Prices based on 1cc hyaluronic acid filler, four threads, 900 RF shots, and 300 HIFU shots
Source: Industry data, Mirae Asset Securities Research

8 | Medtech                                                                                                                                                Mirae Asset Securities Research
Medtech (Overweight) Aesthetic devices market: Spotlight on innovation
II. Minimally invasive: Energy-based devices leading the way

2013-17: M&A fervor                                    •   In the mid-2010s, as the market experienced structural growth, M&As among energy-based aesthetic device
                                                           makers increased sharply.
sweeps market                                          •   Solta Medical developed the world’s first RF-based anti-wrinkle technology in 2002 and grew at a CAGR of 56% in
                                                           the subsequent decade. The firm was acquired by Valeant Pharmaceuticals in 2013 for US$250mn.
                                                       •   In 2009, Ulthera became the first company to apply HIFU technology to skin lifting. The company grew at 83%
                                                           CAGR over the following years, before being acquired by Merz in 2014 for US$600mn.
                                                       •   Zeltiq developed cryolipolysis technology in 2010. The company grew at a CAGR of 49% over the next seven years,
                                                           and was sold to Allergan in 2017 for US$2.5bn.
                                                       •   In 2017, Hologic acquired medical aesthetic device maker Cynosure for US$1.65bn.

 Zeltiq: Revenue trend (before acquisition by Allergan)                                         Cynosure: Revenue trend (before acquisition by Hologic)

(US$mn)                                                                                          (US$mn)
450                                                                                              500
                                                                                   404.5
                                                                                                 450                                                                                                          433.5
400
                                                                           354.2
                                                                                                 400
350
                                             CAGR: 49%                                           350                                                                                                  339.5
                                                                                                                                                    CAGR: 23%
300
                                                                                                                                                                                              292.4
                                                                   255.4                         300
250
                                                                                                 250                                                                                  226.0
200                                                        174.5
                                                                                                 200
150                                                                                                                                                                           153.5
                                                                                                                                                  139.7
                                                 111.6                                           150                                      124.3
                                                                                                                                                                      110.6
100                                   76.2
                            68.1                                                                 100                               78.4                   72.8 81.8
                                                                                                                            56.3
 50                                                                                                                  41.6
                   25.5                                                                           50     23.0 27.1
          1.6
  0                                                                                                 0
          09        10       11        12         13        14      15      16      17                   02    03    04     05     06      07      08     09   10      11      12      13      14      15      16
Source: Edgar, Mirae Asset Securities Research                                                Source: Edgar, Mirae Asset Securities Research

9 | Medtech                                                                                                                                                            Mirae Asset Securities Research
II. Minimally invasive: Energy-based devices leading the way
Since 2018:                                        •    Since the late 2010s, market growth has been driven by companies that generate high gross and OP margins.

Innovative companies                               •    Technological innovation has led to high levels of customer satisfaction, justifying high selling prices and
                                                        lowering marketing expenses.
drive market growth                                •    Based on its RF-assisted lipolysis (RFAL) and fractional RF technologies, InMode boasts a high ASP of US$120,000-
                                                        130,000 (vs. US$50,000-70,000 for other laser device makers). As such, the company displays a high OP margin of
                                                        85% despite its relatively low sales mix of consumables (12%).
                                                   •    Classys has expanded the mid-end market thanks to the high functional value of its products. Although its ASP is
                                                        around half that of Ulthera, Classys has recorded an OP margin of 53%, buoyed by increased consumable sales
                                                        (gross margin estimated at 90%) stemming from explosive demand growth.

 Classys: Revenue and OP margin trends                                                          InMode: Revenue and OP margin trends

 (US$bn)                                                                            (%)         (US$mn)                                                                             (%)
120                      Revenue (L)                    OP margin (R)                 60        300                  Revenue (L)        OP margin (R)                                 45
                                                                                                                                                                           279.0

                                                                                      55                                                                                              40
100                                                                         96.6                250
                                                                                                                                                                                      35
                                                                                      50                                                                       206.1
                                                       81.1
  80                                                               76.5                         200                                                                                   30
                                                                                      45
                                                                                                                                                 156.4                                25
  60                                                                                  40        150
                                        47.5                                                                                                                                          20
                                                                                      35                                             100.2
  40                      34.9                                                                  100                                                                                   15
            27.2                                                                      30                                57.7                                                          10
  20                                                                                             50
                                                                                      25                   23.1                                                                       5

   0                                                                                  20          0                                                                                   0
             16            17            18            19           20       21F                            16           17            18          19           20          21F
Source: Classys, Mirae Asset Securities Research                                               Source: InMode, Mirae Asset Securities Research

10 | Medtech                                                                                                                                             Mirae Asset Securities Research
III. Invasive: Innovations in breast implant market
Global breast implant                            •    In the aesthetics market, although minimally invasive procedures are coming into greater focus, more invasive
                                                      surgeries are still expanding.
market to grow at 7%
                                                 •    Globally, the most widely performed cosmetic surgery is breast augmentation, with key markets being the US,
CAGR                                                  Brazil, and China.
                                                 •    In 2019, breast augmentation accounted for the largest share (16%; 1.8mn procedures) of total cosmetic
                                                      surgeries performed globally (11.4mn), due in large part to: 1) the absence of a non-invasive substitute; and 2)
                                                      rising demand stemming from social media and fashion trends.
                                                 •    We expect the global breast implant market to grow at a CAGR of 7% to US$3.05bn in 2027.

 Global cosmetic surgery statistics                                                           Global breast implant market outlook

(‘000 procedures)             2014        2015       2016     2017     2018      2019        (US$bn)

Breast augmentation          1,348       1,489       1,649    1,677    1,863    1,796          3.1
                                                                                                                                     CAGR: +7.2%
                                                                                                                                                                 3.05
Liposuction                  1,373       1,395       1,453    1,574    1,733    1,705          3.1

Double eyelid surgery        1,427       1,265       1,348    1,347    1,100    1,260          3.0

Abdominoplasty                 683         759        769      802      889       924          3.0

Rhinoplasty                    849         730        787      877      727       822          2.9
Breast lift                    499         512        583      658      710       741
                                                                                               2.9
Breast reduction               432         423        466      489      534       600
                                                                                               2.8
Facial fat grafting            966         592        597      603      542       599
                                                                                                                       2.76
                                                                                               2.8
Buttock augmentation           222         289        332      372      347       479
                                                                                               2.7
Facelift                       477         412        427      465      399       448
                                                                                               2.7
Other                        1,218       1,969       2,434    2,270    2,163    2,438
                                                                                               2.6
Total                        9,018       9,423   10,417      10,669   10,607   11,364                                   19                                       27
Source: ISAPS, Mirae Asset Securities Research                                              Source: Fortune Business Insights, Mirae Asset Securities Research

11 | Medtech                                                                                                                                            Mirae Asset Securities Research
III. Invasive: Innovations in breast implant market
Global breast augmentation data by country

                                10               11         13          14          15          16          17          18                19      Share

US                       275,038            284,351    313,703     297,297     309,985     331,122     345,236     321,362          269,514        15%

Brazil                   173,328            148,962    226,090     185,042     166,430     217,085     235,950     275,283          211,287        12%

Mexico                     68,978            72,712     57,691      45,570      61,613      62,206      64,478      70,165           74,637        4%

Russia                     22,758            20,572                                         84,235                                   67,896        4%

Germany                    37,653            36,816     55,160      47,905      53,376      52,209      46,165      65,876           66,972        4%

Italy                      66,765            62,055     26,520                  23,400      54,128      54,045      64,976           56,073        3%

France                     42,504            41,484                 40,442      41,924      47,510                                   53,938        3%

Spain                      25,016            25,135     38,820                              46,493                                   48,559        3%

Turkey                     19,348            14,680                                         38,484                                   45,893        3%

Colombia                   45,562            38,779     44,403      39,881      46,702      44,080      45,570      42,774           39,720        2%

Korea                      34,025            35,325                 23,950      50,553

India                      50,600            24,859                             29,606      32,920

Japan                      49,474            52,220                 15,169                  20,270       7,751

China                      54,700            56,840

Others                   297,030            290,461   1,011,198    652,941     705,403     618,529     878,125    1,022,070         861,062        48%

Total                  1,262,779         1,205,251    1,773,585   1,348,197   1,488,992   1,649,271   1,677,320   1,862,506       1,795,551       100%

Source: ISAPS, Mirae Asset Securities Research

12 | Medtech                                                                                                                  Mirae Asset Securities Research
III. Invasive: Innovations in breast implant market
Market is highly                                    •   The breast implant market began in 1962, when the first breast enlargement surgery using silicone implants was
                                                        performed. The market is now highly oligopolistic, with Allergan (AbbVie), Mentor (J&J), GC Aesthetics, and Sientra
oligopolistic due to strict
                                                        controlling 85% of the market.
regulations and M&As                                    1) Medical markets that require invasive surgeries tend to be fairly conservative due to safety issues.
                                                        2) Innovation suffered a setback when worries about side effects forced the US FDA to suspend the
                                                           manufacturing and sales of silicone implants from 1992 to 2006. Larger companies that survived continued to
                                                           acquire smaller firms.
                                                    •   In terms of filling type, cohesive gel (semi-solid silicone) implants are the most widely used, followed by saline
                                                        and liquid silicone.
 In 1992, the US FDA banned silicone-filled breast implants                                     Global breast implant M/S

                                                                                                                                15%

                                                                                                                                                        85%

                                                                                                                                       Big 4    Other

Source: Allergan, Mirae Asset Securities Research                                              Source: MarketWatch, Mirae Asset Securities Research

13 | Medtech                                                                                                                                             Mirae Asset Securities Research
III. Invasive: Innovations in breast implant market
A new player is taking                             •   Breast implants can be divided into three types (smooth, micro-textured, and macro-textured) based on their
                                                       surface treatment.
the oligopolistic breast
                                                   •   Macro-textured and tear-drop (anatomical) implants were previously the most popular implants in the market.
implant industry by
                                                   •   However, reoperation rates were around 24-36% due to side effects such as capsular contracture and rupture.
storm (1)                                          •   Establishment Labs entered the market in 2011 by receiving the CE mark certification for micro-textured (round-
                                                       type) implants.
                                                   •   As of Oct. 2020, the rate of capsular contracture/implant rupture in the company’s 1.3mn implants placed in the
                                                       past decade stands at less than 1%.

 Established players’ clinical data (24-36% reoperation rate)                                 Establishment Labs’ clinical data

                                                                                                                           Internal clinical data                External clinical data

                                                                                              Tracking period              Oct. 2010-Mar. 2018                   Apr. 2013-Apr. 2016

                                                                                              No. of breast
                                                                                                                             446,773 implants                        5,813 patients
                                                                                              plants/patients

                                                                                              Ruptures                        Less than 0.1%                               None

                                                                                              Capsular
                                                                                                                              Less than 0.1%                               None
                                                                                              contracture

                                                                                                                                                               0.76% (8.43% for control
                                                                                              Reoperation                           None
                                                                                                                                                                        group)

Source: Establishment Labs, Mirae Asset Securities Research                                  Note: External clinical data published in Aesthetic Surgery Journal in 2017
                                                                                             Source: Establishment Labs, Mirae Asset Securities Research

14 | Medtech                                                                                                                                               Mirae Asset Securities Research
III. Invasive: Innovations in breast implant market
A new player is taking                            •    Backed by its innovative breast implant technology, Establishment Labs recorded an astonishing 75% CAGR from
                                                       2015 to 2019 (before turning to negative growth in 2020 due to the pandemic).
the oligopolistic breast
                                                  •    The company is making rapid progress in many regions, capturing the largest market share in Korea (one of the
implant industry by                                    world’s most competitive markets) and holding a 40% market share in Sweden.
storm (2)

 Domestic breast implant M/S                                                                 Establishment Labs revenue

 (%)                                                                             (%)        (US$mn)                                                                                  (%)
30                     Motiva (L)            Allergan + Mentor (R)               90          35                      Revenue (L)               YoY (R)                               140

                                                                                                                                                                                     120
                80                                                               80          30
25                                              25                         25                                                                                                        100
                                23                              23               70
                                                                                             25                                                                                      80
20                                                                               60
                                                                                                                                                                                     60
                                                                                             20
                                                                                 50                                                                                                  40
                                                47
15                              44                              43                                                                                                                   20
                                                                                 40          15
                                                                                                                                                                                     0
10                                                                         31    30
                                                                                             10                                                                                      -20
                                                                                 20
 5                                                                                                                                                                                   -40
                                                                                              5
                                                                                 10
                                                                                                                                                                                     -60

 0             0                                                                 0            0                                                                                      -80
           4Q15            3Q17            4Q17            1Q18        3Q18                       1Q17      3Q17     1Q18      3Q18     1Q19      3Q19       1Q20    3Q20     1Q21
Source: Hans BioMed, Mirae Asset Securities Research                                        Source: Establishment Labs, Mirae Asset Securities Research

15 | Medtech                                                                                                                                              Mirae Asset Securities Research
III. Invasive: Innovations in breast implant market
Market shift arising from                           •    Since 2018, a number of breast implant associated anaplastic large cell lymphoma (BIA-ALCL) cases were
                                                         reported in women with macro-textured breast implants, which are treated to have a rough surface so that they
BIA-ALCL issue
                                                         adhere to the breast tissue.
                                                    •    Allergan (AbbVie) was forced to recall its macro-textured type breast implants and scale back its presence to the
                                                         US, Canada, China, and Japan.
                                                    •    The breast implant market is highly conservative by nature, and the correlation between macro-textured type
                                                         implants and BIA-ALCL was enough to change the perceptions of patients and physicians.
                                                    •    We expect makers of micro-textured/smooth-type implants to gain further market share as a result.

 Allergan’s (currently AbbVie) breast implant revenue                                             Three types of breast implants (based on surface treatment)

(US$mn)                                                                                    (%)
140                      Breast implants (L)            YoY (R)                            30

                                                           Recall of macro-textured type   20
120                                                               breast implants
                                                                                           10

100                                                                                        0

                                                                                           -10
  80
                                                                                           -20

                                                                                           -30
  60
                                                                                           -40
  40                                                                                       -50

                                                                                           -60
  20
                                                                                           -70

   0                                                                                       -80
       2Q16       4Q16       2Q17       4Q17        2Q18      4Q18      2Q19       4Q19
Source: Allergan, Mirae Asset Securities Research                                                Source: Establishment Labs, Mirae Asset Securities Research

16 | Medtech                                                                                                                                                   Mirae Asset Securities Research
IV. Domestic market trends

Outbound demand:   •    Initially, domestic energy-based aesthetic device makers generally relied on low prices to compete with global
                        peers.
Growing exports
                   •    However, after accumulating know-how and clinical data in the domestic market, they started to look for growth
                        opportunities overseas.
                   •    The COVID-19 outbreak put the brakes on overseas expansion efforts (import restrictions, social distancing
                        measures, etc.), but exports have steadily recovered since 2Q20.
                   •    Notably, growing exports to the US (over 40% of the global aesthetic device market) should set the stage for a
                        valuation re-rating for domestic players.

                       Domestic aesthetic device makers’ export trend

                    (US$mn)                                                                                                              (%)
                     200                    Exports (L)             YoY (R)                                                               30

                       180
                                                                                                                                         20
                       160
                                                                                                                                         10
                       140
                                                                                                                                         0
                       120

                       100                                                                                                               -10

                        80
                                                                                                                                         -20
                        60
                                                                                                                                         -30
                        40
                                                                                                                                         -40
                        20

                         0                                                                                                               -50
                             1Q15               1Q16                   1Q17   1Q18            1Q19             1Q20               1Q21

                   Note: Based on HS code 901890
                   Source: TRASS, Mirae Asset Securities Research

17 | Medtech                                                                                                 Mirae Asset Securities Research
IV. Domestic market trends
Inbound demand:                                  •   A growing number of people are visiting Korea for medical/aesthetic treatments.
Medical tourism on the                           •   Most of the visitors are from China and Southeast Asian countries.

rise                                             •   The most popular procedures are cosmetic surgery and cosmetic dermatology treatments.
                                                 •   Tourist numbers have plummeted since the COVID-19 outbreak. As travel restrictions ease, however, we think
                                                     medical tourism will become one of the key growth drivers for the domestic energy-based aesthetic devices
                                                     market.

 Share of foreign patients by specialty (2019)                                                 No. of foreign patients and YoY growth

                                                                                              ('000)                                                                                 (%)
                                                                                              600                   No. of patients (L)        YoY (R)                                60
                                                              Internal medicine
           Other                                                    23%
           23%                                                                                                                                                                        50
                                                                                              500

                                                                                                                                                                                      40

                                                                                              400
                                                                                                                                                                                      30

                                                                                              300                                                                                     20

                                                                            Plastic surgery                                                                                           10
 OB/GYN                                                                          18%          200
   8%
                                                                                                                                                                                      0

                                                                                              100
            Medical exams                                                                                                                                                             -10
                11%
                                                      Dermatology
                                                         17%                                     0                                                                                    -20
                                                                                                        09     10      11      12         13   14    15     16    17     18    19
Source: KHIDI, Mirae Asset Securities Research                                                Source: KHIDI, Mirae Asset Securities Research

18 | Medtech                                                                                                                                              Mirae Asset Securities Research
Classys (214150 KQ)                                                                                                                                                                            Top pick

Going global

                                                    Investment points
(Initiate)                                 Buy
                                                    •     High-margin structure supported by consumables business model: Gross margin has expanded from 69.8% in
                                                          2017 to 79.7% in 2020.
Target price (12M, W)                19,000
                                                    •     Worries over Brazil offset by growing exports elsewhere: Earnings are rapidly improving, led by Japan,
                                                          Australia, and Russia.
Current price (5/24/21, W)               14,250     •     Stable cash flow: Cash assets have increased from W10.5bn at end-2018 to W66.8bn at end-1Q21. Debt ratio
                                                          has also declined to 14.9%.
Expected return                            33%

                                                    Valuation and recommendation
                                                    •     We initiate our coverage on Classys with a Buy rating and target price of W19,000.
OP (21F, Wbn)                                52     •     The stock is currently trading at a 12-month forward P/E of 19.9x, a discount to global peers (22x).
Consensus OP (21F, Wbn)                      54     •     Risks: 1) COVID-19 resurgence; 2) persistent weakness in exports to Brazil; 3) increasing domestic competition;
EPS growth (21F, %)                         12.5          and 4) lack of progress in business diversification
P/E (21F, x)                                21.5

Market P/E (21F, x)                         11.8

KOSDAQ                                    948.37

Market cap (Wbn)                            922    150
                                                                CLASSYS                          (Dec.)                       2018            2019            2020         2021F       2022F       2023F
Shares outstanding (mn)                      65    140          KOSDAQ                           Revenue (Wbn)                   47             81              76               97      118         142
Free float (%)                              25.9   130                                           OP (Wbn)                        17             42              41               52       63          75

Foreign ownership (%)                        7.9   120                                           OP margin (%)                 36.2            51.9           53.9              53.6    53.4         52.8
Beta (12M)                                  0.49                                                 NP (Wbn)                        15             33              38               43       52          62
                                                   110
52-week low (W)                           11,950                                                 EPS (W)                        242            534            590               664      802         958
                                                   100
52-week high (W)                          17,500                                                 ROE (%)                       34.5            48.1           36.1              30.0    27.8         25.8
                                                   90
(%)                       1M      6M       12M                                                   P/E (x)                       16.8            26.5           26.1              21.5    17.8         14.9
                                                   80
Absolute                   2.9    -5.9     -12.6                                                 P/B (x)                         5.0           10.4            8.1               5.7     4.4          3.4
                                                   70
Relative                  11.4   -13.5     -34.7         20.5 20.7   20.9 20.11 21.1 21.3 21.5   Div. yield (%)                  0.3            0.3            0.4               0.4     0.4          0.4
                                                                                                 Notes: Under consolidated K-IFRS; NP is attributable to owners of the parent
                                                                                                 Source: CLASSYS, Mirae Asset Securities Research estimates

19 | Medtech                                                                                                                                                            Mirae Asset Securities Research
Classys (214150 KQ)
Investment point 1:                                     •   Classys’s biggest strength is its high-margin consumables-based business model.
High-margin structure                                   •   Each of the company’s Shurink cartridges can typically deliver 12,000 shots and must be replaced after 40
                                                            uses.
supported by consumables
                                                        •   We believe COGS ratio is around 30% for devices and 10% for consumables.
business model
                                                        •   The company has supplied roughly 6,000 devices as of end-2020.
                                                        •   Growing devices revenue has naturally led to an increase in the revenue mix of consumables (from 26% in
                                                            2017 to 49% in 2020).
                                                        •   In the process, gross margin has expanded from 69.8% in 2017 to 79.7% in 2020.

 Revenue breakdown by product (43-47% for consumables)                                         Consumables mix vs. gross margin trend

                                                                                               (%)                                                                                    (%)
                      Classys     Cluederm        Consumables     Skederm
                                                                              1%               55               Consumables sales mix (L)                                              85
         2%                3%                3%                 2%
                                                                                                                Gross margin (R)

                                                                                               50
        26%
                          33%                                                                                                                                                         80
                                             43%                49%           47%
                                                                                               45
        11%
                                                                                                                                                                                      75
                          11%                                                                  40

                                             8%
                                                                6%            8%
                                                                                               35
                                                                                                                                                                                      70

        60%                                                                                    30
                          53%
                                             45%                43%           43%                                                                                                     65
                                                                                               25

                                                                                               20                                                                                     60
         17                18                19                 20           1Q21                    1Q17    3Q17      1Q18        3Q18     1Q19      3Q19   1Q20     3Q20     1Q21

Source: Company data, Mirae Asset Securities Research                                         Source: Company data, Mirae Asset Securities Research

20 | Medtech                                                                                                                                             Mirae Asset Securities Research
Classys (214150 KQ)
Investment point 2:                                •    On top of Classys’s phenomenal top-line growth in the domestic market, exports have continued to increase
                                                        in recent years. Brazil, in particular, has stood out as the most important export market.
Worries over Brazil offset
                                                   •    For this reason, the resurgence of COVID-19 in Brazil has sparked worries about revenue.
by growing exports
                                                   •    On the bright side, revenue growth is rapidly improving elsewhere, especially in Japan, Australia, and Russia.
elsewhere                                               The revenue mix of regions outside Korea and Brazil has risen from 39% in 2018 to 54% in 1Q21.
                                                   •    Rather than excessively worrying over the risk in Brazil, we advise focusing on the company’s expansion in
                                                        other export markets.

 Brazil revenue trend                                                                           Ex-Brazil export trend

(Wbn)                                                                               (%)        (Wbn)                                                                               (%)
4.0             Brazil (L)            YoY (R)                                       350        14.0            Other regions (L)              YoY (R)                               50

                                                                                    300                                                                                             40
3.5                                                                                            12.0
                                                                                    250                                                                                             30
3.0
                                                                                               10.0                                                                                 20
                                                                                    200
2.5                                                                                                                                                                                 10
                                                                                    150
                                                                                                8.0

2.0                                                                                 100                                                                                             0
                                                                                                6.0
                                                                                    50                                                                                              -10
1.5
                                                                                    0           4.0                                                                                 -20
1.0
                                                                                    -50                                                                                             -30
                                                                                                2.0
0.5                                                                                                                                                                                 -40
                                                                                    -100

0.0                                                                                 -150        0.0                                                                                 -50
        1Q18       3Q18        1Q19         3Q19         1Q20      3Q20      1Q21                      1Q18       3Q18        1Q19        3Q19          1Q20      3Q20      1Q21
Source: Company data, Mirae Asset Securities Research                                         Source: Company data, Mirae Asset Securities Research

21 | Medtech                                                                                                                                            Mirae Asset Securities Research
Classys (214150 KQ)
Investment point 3:                               •     Classys has continued to generate healthy free cash flow thanks to its strong revenue growth and high-
                                                        margin business structure.
Stable cash flow
                                                  •     As a result, cash assets have increased from W10.5bn at end-2018 to W66.8bn at end-1Q21.
                                                  •     Debt ratio has also declined from 48.3% at end-2018 to 14.9% at end-1Q21, further strengthening the balance
                                                        sheet.
                                                  •     Stable cash flow and the high percentage of cash holdings should allow the company to pursue M&A deals or
                                                        invest in R&D.

 Cash and equivalents                                                                         Free cash flow trend

(Wbn)                                                                                         (Wbn)
80                                                                                            20          FCF
                      Cash and equivalents                                                    15
70
                                                                                              10
60
                                                                                               5
50
                                                                                               0

40                                                                                            -5

                                                                                             -10
30
                                                                                             -15
20
                                                                                             -20

10
                                                                                             -25

 0                                                                                           -30
     1Q17      3Q17       1Q18     3Q18      1Q19       3Q19    1Q20    3Q20    1Q21               1Q17      3Q17      1Q18      3Q18      1Q19      3Q19    1Q20     3Q20    1Q21
Source: Company data, Mirae Asset Securities Research                                        Source: Company data, Mirae Asset Securities Research

22 | Medtech                                                                                                                                          Mirae Asset Securities Research
Classys (214150 KQ)
Earnings forecasts                                •    For 2021, we forecast revenue to grow 26.4% YoY to W96.6bn.
                                                  •    For Korea and Brazil, both of which are still grappling with COVID-19, we see meager growth of 2.4% and 0.1%
                                                       YoY, respectively. However, as economies elsewhere reopen on the back of vaccine distribution, we expect
                                                       exports (excluding Brazil) to expand 59.2% YoY, driving overall top-line growth.
                                                  •    While there are concerns over domestic earnings, new product rollouts (Shurink Universe and Volnewmer) later
                                                       this year/early next year should have positive effects.
                                                  •    We forecast operating profit to grow 26.9% YoY to W51.5bn (OP margin of 53.3%).

 Earnings forecasts

(Wbn)                               1Q20           2Q20           3Q20      4Q20       1Q21       2Q21F       3Q21F       4Q21F          2020       2021F         2022F

Revenue                              21.4             14.6        19.6       20.9       21.3        24.1        25.1        26.1         76.5         96.6        118.2

 Classys                               9.2             5.8         8.2        9.7         9.2       10.0        10.5        11.0         32.9         40.7          50.4

 Cluederm                              1.4             0.7         1.2        1.1         1.8        2.3         2.4         2.2          4.4          8.7          10.4

 Consumables                         10.5              7.6         9.9        9.8       10.1        11.3        11.9        12.5         37.7         45.8          55.9

 Cosmetics                             0.3             0.5         0.3        0.3         0.2        0.4         0.3         0.4          1.4          1.3            1.5

OP                                   13.4              6.4        11.9        8.9       10.9        12.9        13.5        14.2         40.6         51.5          63.1

Pretax profit                        14.7              6.2        11.5        6.9       12.6        12.9        13.6        14.2         39.3         53.3          63.3

NP (owners of parent)                11.4              4.7         8.8       13.2         9.6       10.6        11.1        11.7         38.2         43.0          51.9

OP margin (%)                        62.7             43.6        60.6       42.8       51.1        53.5        53.9        54.4         53.1         53.3          53.4

Pretax margin (%)                    68.6             42.5        58.6       33.2       58.9        53.6        54.1        54.5         51.4         55.1          53.6

Net margin (%)                       21.4             14.6        19.6       20.9       21.3        24.1        25.1        26.1         76.5         96.6        118.2

Source: Company data, Mirae Asset Securities Research estimates

23 | Medtech                                                                                                                              Mirae Asset Securities Research
Classys (214150 KQ)
Valuation and risks   •     We present a target price of W19,000 on Classys. With 33.3% upside potential, we present a Buy rating on the
                            stock.
                      •     We derived our target price by applying a P/E of 25x—the stock’s peak multiple over the past year—to our 12-
                            month forward net profit estimate of W46.7bn.
                      •     We view our target valuation as highly achievable, considering: 1) the stock’s historical peak multiple of 28x; and
                            2) the fact that aesthetic companies with high exposure to consumables have traded at the upper end of the 20x
                            range or above 30x P/E during their high-growth periods.
                      •     At present, Classys is trading at a 12-month forward P/E of 19.9x, in line with global peers (22x).
                      •     Risks: 1) COVID-19 resurgence; 2) persistent weakness in exports to Brazil; 3) increasing domestic competition;
                            and 4) lack of progress in business diversification.

                          Valuation

                                                                             Value                              Notes

                          Target multiple (x)                                   25     Peak P/E multiple over the past year

                          NP (Wbn)                                             46.7    12-month forward EPS

                          Valuation (Wbn)                                    1,167

                          Share count (shares)                          64,716,864      As of end-Mar. 2021

                       Target price (W)                                     19,000

                       Current price (W)                                    14,250

                          Upside potential (%)                               33.3%

                      Source: TRASS, Mirae Asset Securities Research

24 | Medtech                                                                                                         Mirae Asset Securities Research
Classys (214150 KQ)

 Global peer valuation                                                                                                                                                                      (Wbn)

                        Market              OP margin (%)                       P/E (x)                          P/S (x)                           ROE (%)                   Revenue (Wbn)
                           cap              20      21F      22F           20      21F         22F         20         21F       22F          20       21F        22F         20     21F      22F
InMode                    2,960         35.3       38.7     38.1       30.4        25.1        23.1      11.2          9.4       7.9       34.9       33.6      26.9      243       314      376
Hugel                     2,537         37.0       41.0     42.4       46.6        32.9        26.2      10.9          9.5       7.9        5.8        9.7      11.1      211       268      322
Establishment
                          1,761         -33.0      -16.2     -9.6           -         -              -   17.3         13.1     10.4       -33.5      -39.5      -47.0     100       134      169
Labs
Medytox                   1,095         -26.3        1.6    18.4            -         -              -     6.8         7.0       5.8      -11.8        4.3      13.0      141       157      190
Classys                        903      53.1       56.8     58.0       24.9        19.5        15.4      11.8          9.0       7.1       36.0       32.3      30.7         76     101      127
L&C Bio                        643      22.2       29.7     31.0       59.8           -              -   19.6         15.3     11.7        18.6       13.9      16.0         33      42        55
Cutera                         589      -15.5        0.3      5.1           -         -              -     3.1         2.5       2.3      -31.5        1.4       5.5      174       229      254
Lutronic                       275          5.4    14.7     27.9            -      15.0            6.5     2.2         1.9       1.6      -14.7       15.6      28.1      116       145      173
Venus Concept                  110      -87.0      -20.8    -10.7           -         -              -     0.9         1.0       0.8     -144.0             -       -        92     114      139
Avg.                                     -1.0      16.2     22.3       40.4        23.1        17.8        9.3         7.6       6.2      -15.6        8.9      10.5      132       167      200
Source: Bloomberg, Mirae Asset Securities Research

 Foreign and institutional net buying                                                                     12-month forward P/E band chart
 (Wbn)                                                                                      (W)            (W)
140                 Share price (R)                                                       20,000                                                                             30x             25x
                                                                                                         20000
120                 Domestic institutions (L)                                             18,000         18000
100                                                                                       16,000         16000                                                                               20x
                    Foreign investors (L)
 80                                                                                       14,000         14000
                                                                                          12,000         12000                                                                               15x
 60
                                                                                          10,000         10000
 40
                                                                                          8,000           8000                                                                               10x
 20                                                                                       6,000           6000
  0                                                                                       4,000           4000
-20                                                                                       2,000           2000
-40                                                                                       0                  0
      1/17   7/17       1/18     7/18       1/19    7/19   1/20     7/20    1/21                                 18                 19                 20               21
Source: Mirae Asset Securities Research                                                                  Source: Mirae Asset Securities Research

25 | Medtech                                                                                                                                                       Mirae Asset Securities Research
Classys (214150 KQ)
Company overview   •    Established in 2007, Classys went public on the KOSDAQ in 2017 through a merger with KTB SPAC 2.
                   •    The company’s core product is Shurink, an HIFU facelift device.
                   •    The company has a consumables-based business model that generates high margins and has supplied around
                        6,000 devices globally as of end-2020. The revenue mix of consumables overtook that of devices in 2020.
                   •    More than 60% of revenue comes from exports, with the biggest export market being Brazil.

                       Classys’s flagship brand Shurink

                   Source: Company materials, Mirae Asset Securities Research

26 | Medtech                                                                                              Mirae Asset Securities Research
Classys (214150 KQ)
Key charts

 Revenue breakdown by region                                                                              Revenue breakdown by product
                            Korea       Brazil        Other                                                                 Classys     Cluederm     Consumables   Skederm
                                                                                                               2%                3%                3%            2%               1%

                                                                                                              26%
                                            39%               43%                                                               33%
                          49%                                                     54%                                                              43%            49%             47%
         63%                                                                                                  11%
                                                                                                                                11%
                                            12%
                                                              12%                                                                                  8%                             8%
                           9%                                                                                                                                     6%
                                                                                  10%
         4.8%
                                                                                                              60%               53%
                          42%               49%               45%                                                                                  45%            43%             43%
        32.6%                                                                     36%

          17               18                19                20                 1Q21                         17                18                19             20             1Q21
Source: Company data, Mirae Asset Securities Research                                                 Source: Company data, Mirae Asset Securities Research

                                                   Ownership breakdown

                                                                                            Other
                                                                                            18%

                                                                    Foreign investors
                                                                           8%
                                                                                                                     Jung Sung-jae
                                                                                                                         51%

                                                                               Affiliates
                                                                                 23%

                                                  Source: Company data, Mirae Asset Securities Research

27 | Medtech                                                                                                                                                  Mirae Asset Securities Research
Classys (214150 KQ)
Income statement (summarized)                                                Balance sheet (summarized)                                   Key valuation metrics/ratios

(Wbn)                                2020       2021F        2022F   2023F   (Wbn)                         2020   2021F   2022F   2023F                                  2020     2021F     2022F     2023F

Revenue                                 76          97        118     142    Current assets                  83    124     175     237    P/E (x)                         26.1     21.5      17.8      14.9

Cost of revenue                         16          19         24      28    Cash & equivalents              64     96     142     198    P/CF (x)                        22.5     17.1      14.1      11.9

GP                                      60          78         94     114    AR & other receivables           3      4       5       6    P/B (x)                          8.1       5.7       4.4       3.4

SG&A expenses                           20          26         31      39    Inventory                       10     12      15      18    EV/EBITDA (x)                   21.7     15.2      11.7        9.2

OP (adj.)                               41          52         63      75    Other current assets             6     12      13      15    EPS (W)                         590       664       802       958

OP                                      41          52         63      75    Non-current assets              55     56      57      57    CFPS (W)                        684       834     1,011     1,199

Non-operating profit                     -2           1         0       1    Investments in associates        0      0       0       0    BPS (W)                        1,913    2,516     3,259     4,157

Net financial income                      0           0         0       0    PP&E                            50     51      51      51    DPS (W)                          60        60        60        60

Net income from associates                0           0         0       0    Intangible assets                1      1       1       1    Dividend payout ratio (%)       10.2       9.0       7.5       6.3

Pretax profit                           39          53         63      76    Total assets                   138    180     232     294    Dividend yield (%)               0.4       0.4       0.4       0.4

Income tax                                1         10         11      14    Current liabilities             13     17      20      24    Revenue growth (%)              -6.2     27.6      21.6      20.3

Profit from continuing opera            38          43         52      62    AP & other payables              1      1       1       2    EBITDA growth (%)                0.0     25.6      20.4      20.0

Profit from discontinued ope              0           0         0       0    Short-term financial liabil      0      0       0       0    OP growth (%)                   -2.4     26.8      21.2      19.0

NP                                      38          43         52      62    Other current liabilities       12     16      19      22    EPS growth (%)                  10.5     12.5      20.8      19.5

Attributable to owners                  38          43         52      62    Non-current liabilities          0      1       1       1    AR turnover (x)                 27.6     28.3      28.3      28.3

Attributable to minority inter            0           0         0       0    Long-term financial liabili      0      0       0       0    Inventory turnover (x)           8.2       8.6       8.6       8.6

Total comprehensive income              38          43         52      62    Other non-current liabiliti      0      1       1       1    AP turnover (x)                 54.8     52.5      52.5      52.5

Attributable to owners                  38          43         52      62    Total liabilities               14     17      21      25    ROA (%)                         30.4     27.0      25.2      23.6

Attributable to minority inter            0           0         0       0    Equity attributable to own    124     163     211     269    ROE (%)                         36.1     30.0      27.8      25.8

EBITDA                                  43          54         65      78    Capital stock                    6      6       6       6    ROIC (%)                        76.9     77.5      95.1     113.1

FCF                                     37          37         52      62    Capital surplus                 24     24      24      24    Debt-to-equity ratio (%)        11.1     10.6        9.9       9.3

EBITDA margin (%)                     56.6        55.7        55.1    54.9   Retained earnings               93    132     180     238    Current ratio (%)              617.2    736.1     865.3     968.7

OP margin (%)                         53.9        53.6        53.4    52.8   Minority interests               0      0       0       0    Net debt-to-equity ratio (%)   -55.5     -65.0     -72.8     -78.4

Net margin (%)                        50.0        44.3        44.1    43.7   Shareholders' equity           124    163     211     269    Interest coverage ratio (x)    240.4   4,496.9   4,813.7   5,185.8
Source: CLASSYS, Mirae Asset Securities Research estimates

28 | Medtech                                                                                                                                                             Mirae Asset Securities Research
Important disclosures and disclaimers
 Two-year rating and TP history
 Company                                                                            Date               Rating               TP (W)
                                                                                                                                                     (W)                          CLASSYS
 CLASSYS (214150)                                                               05/24/21                  Buy               19,000                 20,000

                                                                                                                                                   15,000

                                                                                                                                                   10,000

                                                                                                                                                    5,000

                                                                                                                                                        0
                                                                                                                                                        May 19                   May 20              May 21

 Stock ratings                                                                                                    Sector ratings
 Buy                Expected 12-month performance: +20% or greater                                                Overweight         Expected to outperform the market over 12 months
 Trading Buy        Expected 12-month performance: +10% to +20%                                                   Neutral            Expected to perform in line with the market over 12 months
 Hold               Expected 12-month performance: -10% to +10%                                                   Underweight        Expected to underperform the market over 12 months
 Sell               Expected 12-month performance: -10% or worse

    Rating and TP history: Share price (─), TP (▬), Not Rated (■), Buy (▲), Trading Buy (■), Hold (●), Sell (◆)
    * Our investment rating is a guide to the expected return of the stock over the next 12 months.
    * Outside of the official ratings of Mirae Asset Securities Co., Ltd., analysts may call trading opportunities should technical or short-term material developments arise.
    * The TP was determined by the research analyst through valuation methods discussed in this report, in part based on estimates of future earnings.
    * TP achievement may be impeded by risks related to the subject securities and companies, as well as general market and economic conditions.

 Ratings distribution and investment banking services
                                                                      Buy                                     Trading Buy                                   Hold                                  Sell
 Ratings distribution                                                79.00%                                       13.00%                                    7.00%                                 1.00%
 Investment banking services                                         63.16%                                       31.58%                                    5.26%                                 0.00%
 * Based on recommendations in the last 12-months (as of March 31, 2021)

29 | Medtech                                                                                                                                                                          Mirae Asset Securities Research
Disclosures
 As of the publication date, Mirae Asset Securities Co., Ltd. and/or its affiliates do not have any special interest with the subject company and do not own 1% or more of the subject company's shares outstanding.

 Analyst certification
 The research analysts who prepared this report (the “Analysts”) are registered with the Korea Financial Investment Association and are subject to Korean securities regulations. They are neither
 registered as research analysts in any other jurisdiction nor subject to the laws or regulations thereof. Each Analyst responsible for the preparation of this report certifies that (i) all views expressed in
 this report accurately reflect the personal views of the Analyst about any and all of the issuers and securities named in this report and (ii) no part of the compensation of the Analyst was, is, or will be
 directly or indirectly related to the specific recommendations or views contained in this report. Mirae Asset Securities Co., Ltd. (“Mirae Asset Securities”) policy prohibits its Analysts and members of their
 households from owning securities of any company in the Analyst’s area of coverage, and the Analysts do not serve as an officer, director, or advisory board member of the subject companies. Except
 as otherwise specified herein, the Analysts have not received any compensation or any other benefits from the subject companies in the past 12 months and have not been promised the same in
 connection with this report. Like all employees of Mirae Asset Securities, the Analysts receive compensation that is determined by overall firm profitability, which includes revenues from, among other
 business units, the institutional equities, investment banking, proprietary trading, and private client divisions. At the time of publication of this report, the Analysts do not know or have reason to know
 of any actual, material conflict of interest of the Analyst or Mirae Asset Securities except as otherwise stated herein.

 Disclaimers
 This report was prepared by Mirae Asset Securities, a broker-dealer registered in the Republic of Korea and a member of the Korea Exchange. Information and opinions contained herein have been
 compiled in good faith and from sources believed to be reliable, but such information has not been independently verified and Mirae Asset Securities makes no guarantee, representation or warranty,
 express or implied, as to the fairness, accuracy, completeness, or correctness of the information and opinions contained herein or of any translation into English from the Korean language. In case of an
 English translation of a report prepared in the Korean language, the original Korean language report may have been made available to investors in advance of this report.
 The intended recipients of this report are sophisticated institutional investors who have substantial knowledge of the local business environment, its common practices, laws, and accounting principles,
 and no person whose receipt or use of this report would violate any laws or regulations or subject Mirae Asset Securities or any of its affiliates to registration or licensing requirements in any
 jurisdiction shall receive or make any use hereof.
 This report is for general information purposes only and is not and shall not be construed as an offer or a solicitation of an offer to effect transactions in any securities or other financial instruments.
 The report does not constitute investment advice to any person, and such person shall not be treated as a client of Mirae Asset Securities by virtue of receiving this report. This report does not take into
 account the particular investment objectives, financial situations, or needs of individual clients. The report is not to be relied upon in substitution for the exercise of independent judgment. Information
 and opinions contained herein are as of the date hereof and are subject to change without notice. The price and value of the investments referred to in this report and the income from them may
 depreciate or appreciate, and investors may incur losses on investments. Past performance is not a guide to future performance. Future returns are not guaranteed, and a loss of original capital may
 occur. Mirae Asset Securities, its affiliates, and their directors, officers, employees, and agents do not accept any liability for any loss arising out of the use hereof.
 Mirae Asset Securities may have issued other reports that are inconsistent with, and reach different conclusions from, the opinions presented in this report. The reports may reflect different
 assumptions, views, and analytical methods of the analysts who prepared them. Mirae Asset Securities may make investment decisions that are inconsistent with the opinions and views expressed in
 this research report. Mirae Asset Securities, its affiliates, and their directors, officers, employees, and agents may have long or short positions in any of the subject securities at any time and may make a
 purchase or sale, or offer to make a purchase or sale, of any such securities or other financial instruments from time to time in the open market or otherwise, in each case either as principals or agents.
 Mirae Asset Securities and its affiliates may have had, or may be expecting to enter into, business relationships with the subject companies to provide investment banking, market-making, or other
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Distribution
 United Kingdom: This report is being distributed by Mirae Asset Securities (UK) Ltd. in the United Kingdom only to (i) investment professionals falling within Article 19(5) of the Financial Services and
 Markets Act 2000 (Financial Promotion) Order 2005 (the “Order”), and (ii) high net worth companies and other persons to whom it may lawfully be communicated, falling within Article 49(2)(A) to (E) of
 the Order (all such persons together being referred to as “Relevant Persons”). This report is directed only at Relevant Persons. Any person who is not a Relevant Person should not act or rely on this
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 investor. Under no circumstances should any recipient of this research report effect any transaction to buy or sell securities or related financial instruments through Mirae Asset Securities. The
 securities described in this report may not have been registered under the U.S. Securities Act of 1933, as amended, and, in such case, may not be offered or sold in the U.S. or to U.S. persons absent
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 Hong Kong: This report is distributed in Hong Kong by Mirae Asset Securities (HK) Limited, which is regulated by the Hong Kong Securities and Futures Commission. The contents of this report have not
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 user assumes the entire risk of any use made of this information. This report has been provided for assistance only and is not intended to be and must not alone be taken as the basis for an investment
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 All other jurisdictions: Customers in all other countries who wish to effect a transaction in any securities referenced in this report should contact Mirae Asset Securities or its affiliates only if distribution
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 such jurisdiction.

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Mirae Asset Securities International Network
 Mirae Asset Securities Co., Ltd. (Seoul)       Mirae Asset Securities (HK) Ltd.                     Mirae Asset Securities (UK) Ltd.
 One-Asia Equity Sales Team                     Units 8501, 8507-8508, 85/F                          41st Floor, Tower 42
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 Tel: 82-2-3774-2124                            Tel: 852-2845-6332                                   Tel: 44-20-7982-8000

 Mirae Asset Securities (USA) Inc.              Mirae Asset Wealth Management (USA) Inc.             Mirae Asset Wealth Management (Brazil) CCTVM
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 Equity Tower Building Lt. 50                   6 Battery Road, #11-01                               7F, Saigon Royal Building
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 Jakarta Selatan 12190                                                                               Vietnam
 Indonesia
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 Tel: 86-21-5013-6392                           Tel: 84-8-3910-7715                                  Tel: 91-22-62661336

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