2019 Massey University and Plant & Food Research - SING Aotearoa

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2019 Massey University and Plant & Food Research - SING Aotearoa
Massey University and
Plant & Food Research

      2019
2019 Massey University and Plant & Food Research - SING Aotearoa
Karakia
                       Ko te Mauri ohooho, whaka ū i te mana,
                     i te wehi, i ahu mai i ngā Kāhui o ngā Ariki!
                 Tukua tēnei mata ohooho ki runga ki ēnei Tauira,
                   ki ēnei Taura, ki ēnei Tama, ngā rerenga o Tū!
                 He whatinga Toka Tapu, he Whāriki raranga a Io,
                   Io Matuanui, te matawhaiapu, te mata āwhio,
                    i ahu mai i te mana āwhiowhio, te arawhata
                   ki te Toi o ngā Rangi, ki te koopu ora o Taane!
                 Tākina mai te Mauri i te hūhā o Hine-te-reremanu,
                        kia puta ki te Wheiao ki te Ao Mārama!
                             Ūhi! Wēro! Tau mai te Mauri!
                              Haumi ee! Hui ee! Tāiki ee!!

(Na Waka Vercoe from Ngāti Awa: This karakia whakamaunu waka refers to the joining
    of the spirits of the people with the spirit of the waka and that of the kaupapa)

                                      He mihi
                             Tuia ko te Rangi e tu nei
                            Tuia ko te Papa e takoto nei
                              Tuia ko te here tangata
                                  Ka rongo te pō
                                  Ka rongo te ao
                                  Tihei mauri ora
    Tuatahi ka huri ra ngā mihi ki a Io te pūkenga, Io te wānanga, Io Matua Kore.
Tuarua ki ngā tini aitua o tēnā iwi, o tēnā iwi puta noa i te motu. Haere koutou ki te
                                huinga o te kahurangi.
   Tuatoru ki ngā whatu mōrehu o rātou mā, ki ngā mana, ki ngā ihi, ki ngā wehi,
          nei ra te mihi maioha ki a koutou i ngakau nui ki tenei kaupapa.
He mihi hoki ki te Te Kunenga ki Pūrehuroa me te Rangahau Ahumara Kai. Na ratou i
             whakaae kia tu tenei wananga whakahikohiko hinengaro.

               No reira, tēnā koutou, tēnā koutou, tēnā koutou katoa.
2019 Massey University and Plant & Food Research - SING Aotearoa
SING AOTEAROA 2019
Welcome to the fourth SING Aotearoa internship programme. The Summer Internship
for Indigenous Genomics is a key capacity building initiative funded by Genomics
Aotearoa.

In recent years there has been significant advances in the fields of genetics and genomics
and an increasing focus on Māori populations and indigenous species. All research
conducted in Aotearoa New Zealand should involve consultation with Iwi Māori so it is
important that we understand enough about the technical, ethical and cultural issues to
engage researchers in robust discussions during that process.

The SING Aotearoa programme is designed to develop your understanding of genomics
alongside some of the best researchers in New Zealand. We are grateful that researchers
like Dr Phil Ross, Dr Patrick Biggs, Prof Barry Scott, Dr Liggy Liggins and Dr Matt
Anderson have made space to spend time with us and share their knowledge and
experience. Make use of this time by asking lots of questions.

The SING Aotearoa workshop is a week-long internship modelled on an existing SING-
USA programme (http://conferences.igb.illinois.edu/sing/home). We are fortunate to
have a faculty mentor from the USA programme coming to join us in Aotearoa. Dr Matt
Anderson will add an international dimension to the programme and bring his
experience working with American Indian and Alaska Native interns.

Massey University and Plant & Food Research are our hosts for 2019. Massey University
is based in Palmerston North, New Zealand, with significant campuses in Albany and
Wellington. Massey University is the only university in New Zealand offering degrees in
aviation, dispute resolution, veterinary medicine, and nanoscience. Plant & Food
Research is a New Zealand-based science company providing research and development
that adds value to fruit, vegetable, crop and food products. We are also grateful for the
time and resources that are being committed by a range of people and organisations
including the Riddet Institute to support this initiative.

While genetics has been a lightning rod for debate in past years we hope that this
workshop provides a space to share ideas and thoughts in an informative way.

Mā te mōhio ka mārama, Mā te mārama ka mātau, Mā te mātau ka ora. Through awareness
comes understanding, through understanding comes knowledge, through knowledge
comes wellbeing. Kia ora koutou katoa.

SING Aotearoa Conveners
Maui Hudson
Phillip Wilcox
Katharina Ruckstuhl
2019 Massey University and Plant & Food Research - SING Aotearoa
Venues
Huia Marae
Address: State Highway 1, 9km east of Waitarere Beach

Massey University
Address:    Riddet Rd, Palmerston North
Phone:      +64 6 356 9099

Plant & Food Research
Address:    Fitzherbert Science Centre Batchelar Road Palmerston North
Phone:      +64 6 953 7700
2019 Massey University and Plant & Food Research - SING Aotearoa
Accommodation
Participants and mentors requiring accommodation will be staying at

Manawatū Halls
The Residential Services Office
Cnr Rehab Road and University Avenue
Massey University
Palmerston North 4442
New Zealand
+64 6 951 6300
+64 0800 22 88 00
2019 Massey University and Plant & Food Research - SING Aotearoa
Programme

Monday, January 21 (Manawatū Halls)

5:00 – 5:45 pm    Check into rooms

6:00 – 8:00 pm    Welcome/reception dinner at accommodation

                  Reception dinner                        Maui Hudson &
                  - Welcome                               Phil Wilcox & Katharina
                  - Whanaungatanga                        Ruckstuhl & Nick
                  - Faculty introductions                 Roskruge
                  - Alumni introductions
                  - Pre-workshop assessment

Tuesday, January 22 (Huia Marae)

7:30 – 8:30 am    Breakfast (accommodation)

9:30 – 10:00 am   Pōwhiri

10:00 – 10:30     Mana whenua kōrero
am

                                  Break – 15 min

11:00 – 12:30     Introduction to Genetics                Phil Wilcox & Simon Hill
pm

                                       Lunch

1:30 – 2:30 pm    CELSI: Cultural Foundation              Maui Hudson & Moe
                  Intro to Tikanga in the Lab             Milne

2.30 – 3.00 pm    Te wero mō te wiki                      Katharina Ruckstuhl

                                  Break – 15 min

3:30 – 5:00 pm    Introduction to Breeding Technologies   Phil Wilcox
                  and Gene Editing

5:00 – 5:15 pm    Participant evaluations of the day

6:00 – 7:00 pm    Dinner at Marae
                  Guest speaker – Phil Ross
2019 Massey University and Plant & Food Research - SING Aotearoa
Wednesday, January 23 (Massey University)

7:30 – 8:30 am    Breakfast (accommodation)

9:00 – 12:00 pm   Plant Genetics Laboratory              Phil Wilcox & David
                                                         Chagne

12:00 – 1:30 pm   Lunch talk – Identifying microbes      Dr Matt Anderson -
                  associated with rheumatoid arthritis   International SING
                  within the Lakota                      faculty

1:30 – 3:00 pm    Bioinformatics lab                     Patrick Biggs and Anne
                                                         McDonald

                                  Break – 30 min

3:30 – 5:00 pm    Approaches to Commercialisation        Jason Mika

5:00 – 5:15 pm    Participant evaluations of the day

6:30 – 8:30 pm    Dinner at Accommodation followed by Debrief

Thursday, January 24 (Plant & Food Research & Riddet Institute)

7:30 – 8:30 am    Breakfast

9:00 – 12.00pm    Plant Gene Editing workshop            David Chagne & Revell
                                                         Drummond
                                                         PFR Seminar Room

12:00 – 1:30 pm   Lunch

1:30 – 2:30 pm    Food Innovation – Partnering with      Melanie Ruffell & Jane
                  Science                                Mullaney

2.30 – 3.30pm     Genetic Research on Taonga Species     Maui Hudson
                                                         Phil Wilcox

                                  Break – 30 min

4:00 – 5:30 pm    Future thinking - Breeding             Nick Albert / David
                  technologies in Aotearoa               Chagne

5:30 – 5:45 pm    Participant evaluations of the day

7:00 pm - late    Dinner at Brew Union with Interns and Faculty
2019 Massey University and Plant & Food Research - SING Aotearoa
Friday, January 25 (Massey University)

7:30 – 8:30 am    Breakfast

9:00 – 10:30 am   Case Studies:

                  Barry Scott:
                  Blaise Forrestor-Gauntlet: Mouse stem cells and genome editing
                  Libby Liggins:

11.00 – 12.30pm   Tikanga and the Lab                     Jordan Housiaux

Lunch

1:30 pm           Final workshop evaluation and           Maui Hudson &
                  poroporoāki                             Phil Wilcox

3:00              Participants return to airport
2019 Massey University and Plant & Food Research - SING Aotearoa
INTERNS for SING Aotearoa 2019
  ❖ Miss Meri Haami
  ❖ Dr. Terri Te Tau
  ❖ Mr. Craig Marwick
  ❖ Mr. Howard Maxwell
  ❖ Mrs. Donna Kerridge
  ❖ Mr. Bronson Rikiriki
  ❖ Miss Anastasia Rickard
  ❖ Mr. John Tiatoa
  ❖ Rev. Rio Greening
  ❖ Miss Essie Van Zuylen
  ❖ Ms. Danielle Sword
  ❖ Mr. Jack Dakin
  ❖ Miss Te Aomihia Walker
  ❖ Ms. Jessica Kereama
  ❖ Miss Oriwia Spooner
  ❖ Miss Summer Wynyard
  ❖ Mr. Cran Gage
  ❖ Mr. Rodrigo Estrada de la Cerda
  ❖ Mr Justin Tamihana
  ❖ Mr Manaaki Davis

SING Alumni
  ❖ Jordan Housiaux

Genomics Aotearoa
  ❖ Ben Te Aika
2019 Massey University and Plant & Food Research - SING Aotearoa
SPEAKERS & MENTORS
Dr Matt Anderson

                           Matt is an assistant professor at The Ohio State University with a joint
                           appointment in the Microbiology Department in the College of Arts
                           and Sciences and the Department of Microbial Infection and
                           Immunity in the College of Medicine. He completed his PhD in the
                           Genetics Department at Stanford University followed by postdoctoral
                           positions in Judith Berman’s lab at the University of Minnesota and
                           Richard Bennett’s lab at Brown University. His research interests
                           center on the evolution of eukaryotic microbes that are relevant to
                           human health. A large contingent within his lab investigates how
                           genetic variability contributes to phenotypic diversity in the most
                           clinically relevant fungal pathogen to humans, Candida albicans.
                           Another major focus of his lab is to describe and understand how the
                           eukaryome, the eukaryotic microbes living on or within their host,
                           contribute to health.

Associate Professor Patrick Biggs
                           Dr Biggs completed an undergraduate degree in Applied
                           Biochemistry at Brunel University in 1992, and then a PhD in familial
                           cancer genetics through the University of London in 1996, both in the
                           UK. He worked in the UK and the USA before taking a position at the
                           Wellcome Trust Sanger Institute where he developed his interest in
                           bioinformatics. In 2007 he moved to New Zealand to work at Massey
                           University, and has been involved in next generation sequencing data
                           generation and analysis over the past 10 years, as part of the Allan
                           Wilson Centre, the Massey Genome Service and New Zealand
                           Genomics Ltd. In 2016 he started his current academic role –
                           Associate Professor in Computational Biology and Genomics – split
                           equally between two Massey University Institutes. His current
                           research interests are in comparative bacterial pathogenomics,
                           particularly species within the Campylobacter, Salmonella and
                           Escherichia genera, and in very high-resolution amplicon-based
                           community typing within species.

Dr David Chagne

                           A Senior Scientist with Plant and Food Research since 2004, Dr
                           Chagné’s research focuses on the application of genetic mapping and
                           genomics to elucidate the genetic control of important plant
                           characters, with a strong underpinning interest in the study of DNA
                           variations in plant genomes.
                           David has catalogued single nucleotide polymorphisms (SNPs) in the
                           apple and pear genomes and identified markers linked to significant
                           traits, including fruit antioxidant content, red flesh and peel,
                           crispness and aroma and further designed a SNP assay that has been
                           used to accurately predict fruit quality of young apple seedlings using
                           genome-wide selection, years before they first set fruit. He is also an
                           honorary senior research fellow at the University of Otago.
Revel Drummond

                             Dr Drummond is a molecular biologist working in the field of plant
                             developmental biology, with most of his time spent actively
                             designing experiments and carrying them out in the laboratory and
                             glasshouse. His research at Plant and Food Research, since joining
                             in 2007, is focused on the discovery and functional characterisation
                             of genes involved in strigolactone (SL) hormone biology. More
                             recently he has developed particular technical expertise in LED
                             lighting systems for optimised plant growth and in CRISPR/Cas9
                             gene editing.

Blaise Forrestor-Gauntlet
                             Blaise completed a Bachelor of Science (2011) and a Master of
                             Science with Honours (2013) at the University of Waikato. She
                             worked as a Māori Intern at AgResearch Ltd from November 2013
                             until starting her PhD in July of 2014 which resulted in a
                             publication (Signal Inhibition Reveals JAK/STAT3 Pathway as
                             Critical for Bovine Inner Cell Mass Development, Meng et al.,
                             2015). Blaise is currently doing her PhD through the University of
                             Waikato and AgResearch under the supervision of Dr Linda Peters
                             and Associate Professor Bjorn Oback, investigating the cellular
                             mechanisms through which mutations in the Grainyhead-like2
                             gene cause progressive hearing loss type DFNA28. She lives in
                             Cambridge with her partner and two young children.

Dr Simon Hills Ngāti Porou
                             Dr Simon Hills (Ngāti Porou) is currently a Research Officer and
                             Research Development Advisor, Māori, at Massey University in
                             Manawatū. Dr Hills is Vice President of the Malacological Society of
                             Australasia, and is a councillor for Genomics for Aotearoa New
                             Zealand. In his research capacity, Simon is interested in the
                             composition, distribution and evolutionary history of the unique
                             ecosystems of Aotearoa. With a primary focus on marine molluscs,
                             Simon uses genetic and genomic data, alongside ecological and
                             paleontological evidence, to uncover the evolutionary history
                             (whakapapa) of native species. In addition to this work, Simon
                             collaborates on iwi/hapu led research on environmental
                             monitoring, conservation genomics, ecological restoration and
                             Māori landscape and ecological classification.

Jordan Housiaux
                             Jordan is a Veterinary Science PhD Candidate at Massey University.
                             Her mahi looks at the interface between mātauranga māori and
                             western science, and their application during whale stranding
                             events. She is interested in attitudes towards genetic research,
                             such as tissue sampling of taonga species, and the process of
                             analysis.
Associate Professor Maui Hudson Whakatōhea, Ngāruahine, Ngā Puhi

                            Maui is an Associate Professor in the Faculty of Māori and
                            Indigenous Studies at the University of Waikato. He is an
                            interdisciplinary researcher with extensive experience across a
                            diverse range of research areas including traditional medicine,
                            indigenous research ethics, interface between indigenous
                            knowledge and science, and Māori data sovereignty. Maui has been
                            a member of a number of national and institutional ethics
                            committees and co-authored Te Ara Tika: Guidelines on Māori
                            Research Ethics – A framework for researchers and ethics
                            committee members, Te Mata Ira Guidelines for Genomic Research
                            with Māori, and He Tangata Kei Tua Guidelines for Biobanking with
                            Māori. He is a co-convener of the SING-Aotearoa programme.

Dr Libby Liggins
                            Libby is a Senior Lecturer in Marine Ecology at Massey University,
                            Auckland. Her research uses molecular genetic and genomic tools
                            to address fundamental questions in population ecology,
                            biogeography, and community ecology in marine systems, with a
                            particular emphasis on understanding the impact of a changing
                            climate. Libby participates in several international research
                            consortia and working groups intended to advance theoretical and
                            applied molecular ecology via interdisciplinary collaboration (for
                            example,       the      Diversity     of      the     Indo-Pacific
                            Network, http://diversityindopacific.net/). In New Zealand, she
                            leads the ‘Ira Moana – Genes of the Sea’ project facilitating the
                            development of a metadatabase for the genetic data of New
                            Zealand organisms.

Anne McCartney
                            Ann Mc Cartney is a Genomics Aotearoa postdoctoral fellow at
                            Manaaki Whenua Landcare Research. She studied Genetics and Cell
                            Biology in Dublin City University, Ireland. From here she was
                            awarded the IRCSET award and undertook her PhD in the
                            Bioinformatics and Molecular Evolution Lab also in DCU under the
                            supervision of Dr. Mary O’Connell. Here she worked on the
                            generation of pipelines for both the identification and
                            characterisation of fusion genes with a specific focus on primate
                            genomes. Since moving to New Zealand in 2018 Ann has worked in
                            Manaaki Whenua creating protocols for the high quality
                            sequencing of endemic New Zealand species including stick insects
                            such as Clitarchus hookeri, fungi from the Herecium clade as well as
                            endemic birds such as the Hihi.
Dr Jason Mika
                                Dr Jason Paul Mika is a descendant of the Ngāi Tūhoe, Whakatōhea,
                                Ngāti Awa and Ngāti Kahungunu tribes of Aotearoa New Zealand.
                                Dr Mika is a senior lecturer and codirector of Te Au Rangahau, the
                                Māori Business & Leadership Research. Dr Mika's research
                                interests include indigenous entrepreneurship, management and
                                methodologies.

Dr Jane Mullaney Ngāti Porou, Ngāti Raukawa
                                I am a scientist and have been with the Food & Bio based Products
                                Group at AgResearch in Palmerston North since 2017. Prior to
                                that, I was at the University of Queensland Australia for just under
                                4 years where I held a post-doctoral fellowship funded by the
                                Juvenile Diabetes Research Foundation (USA) researching how
                                the microbiome and Type 1 diabetes are linked. I have a PHD in
                                Food Technology but my background is in microbiology. During
                                my PhD I worked on how the gut microbiota transform food into
                                bioactives, in particular, broccoli and its anti-cancer effects. While
                                at a food futures hui hosted in Gisborne late 2017, I had a
                                conversation with a Tai Pukenga representative regarding their
                                ambitious plans to develop a commercial growing banana
                                industry on the East Coast. We are now partnering with this
                                group to help develop bananas from tissue culture. We used a
                                novel genetic technology here at AgResearch to identify the
                                Gisborne grown varieties we discovered that are already
                                successfully established there and to carry out some analysis of
                                the nutritional value of these locally grown bananas.

Dr Phil Ross
                                I am a marine ecologist at the University of Waikato. Since 2012 I
                                have worked as a Research Fellow/Post-doc at the University of
                                Waikato's Coastal Marine Field Station in Tauranga. My area of
                                specialty is marine community ecology and molecular ecology
                                with a focus on temperate soft sediment and rocky reef
                                ecosystems. I’m interested in understanding how communities of
                                sea creatures respond to and recover from disturbances,
                                particularly man-made disturbances. For the last few years my
                                research has been focused on trying to determine the ecological
                                effects of the MV Rena grounding on Astrolabe Reef. Recently, I
                                have begun working on toheroa, a large endemic surf clam
                                occurring on only a handful of west coast surf beaches. For this
                                work I will be combining archaeology and population genetics
                                with Matauranga Māori (Māori knowledge) to gain a better
                                understanding of early human influences on the distribution of
                                toheroa and the extent to which early Māori manipulated their
                                marine environment.
Dr Melanie Ruffell
                             Melanie has extensive experience working in the high-value
                             nutrition sector, working closely with relevant stakeholders from
                             academia, government and industry. With a BSc in Human
                             Nutrition (Otago), Melanie’s specialism started in the UK where
                             she spent most of her 15 years away working with food
                             companies, scientists, regulators and policy-makers on health
                             claims for food. Melanie returned to NZ in 2015 to join a
                             premium food manufacturer and exporter, plus has worked with
                             an international provider of agri-tech services. Melanie
                             particularly enjoys developing partnerships and working with
                             diverse teams to help achieve common goals. As the Riddet
                             Institute’s Stakeholder Relationships Manager, Melanie works
                             collaboratively with internal stakeholders (Riddet Institute
                             partner organisations and scientists) and external stakeholders
                             (industry partners, government agencies and other entities like
                             Food HQ, National Science Challenges etc) to ensure project
                             delivery meets the Institute’s mission and contractual
                             responsibilities, and creates value for New Zealand’s agri-food
                             sector. Melanie is also currently refreshing the Riddet’s Māori
                             Strategy and works closely with Māori agri-businesses, iwi and
                             hapū.

Dr Katharina Ruckstuhl Ngāi Tahu, Rangitāne ki Wairau
                             Dr Ruckstuhl is the Associate Dean Māori at the Otago Business
                             School. She is a cross-disciplinary policy researcher in the areas of
                             Māori language, small business, sci-tech innovation, and ‘social
                             licence’ in the mining industry. She contributed a chapter to The
                             Routledge Handbook of Bioarchaeology in Southeast Asia and the
                             Pacific, examining Māori knowledge frameworks in the context of
                             two case studies that involved the return of kōiwi tāngata
                             (ancestral remains). She is currently leading a research team in a
                             national science challenge – Science for Technological Innovation
                             - looking at how sci-tech can better connect with Māori. Katharina
                             has a number of governance, research and other roles for Ngāi
                             Tahu, at both a pan-tribal and for her local hapū of Kāti Huirapa ki
                             Puketeraki.

Prof Barry Scott
                             Barry Scott is Professor of Molecular Genetics at Massey
                             University. His research focuses on understanding the molecular
                             basis of agriculturally beneficial symbiotic interactions between
                             plants and microbes. He was elected a fellow of the Royal Society
                             of NZ in 2010 and awarded a Humboldt Research Award from the
                             Alexander von Humboldt Foundation (Germany) in 2014. Barry is
                             a principal investigator in the Bio-Protection Research Centre, a
                             national centre of research excellence. He was awarded the New
                             Zealand Association of Scientists Marsden Medal (2013).
Dr Phil Wilcox Ngāti Rakaipaaka
                          Dr Wilcox is a Senior Lecturer in the University of
                          Otago’s Department of Mathematics and Statistics, and has
                          experience in applied genomics and statistical genetics. He is the
                          current convenor of MapNet a NZ-wide collective of gene mapping
                          scientists
                          (see https://mapnet.agresearch.co.nz/mediawiki/index.php/MapNet
                          :About) and the Project Leader of the Virtual Institute for Statistical
                          Genetics (www.visg.co.nz). Dr Wilcox also established Te Aroturuki, a
                          group of Māori scientists and advisors who developed a process to
                          assist Western research scientists engage with Māori
                          communities. He is formally a Kaihautu Māori in both the Biological
                          Heritage National Science Challenge and the BioProtection Research
                          CoRE, and is a mandated spokesman for Ngāti Rakaipaaka regarding
                          the Rakaipaaka Health and Ancestry Study. He has worked on
                          genetics of plant species (particularly forest trees) and human
                          diseases.
Contact Information
Programme conveners

Maui Hudson               027 206 1183
Katharina Ruckstuhl       021 161 4820
Phil Wilcox               021 387 892

Programme co-ordinator
Tuti Nikora               027 725 8139

Host institutions

Massey University         Dr Jason Mika – 021 970 421
Plant & Food Research     Dr David Chagne – 027 631 0585

Accommodation:            Manawatū Halls
                          The Residential Services Office
                          Cnr Rehab Road and University Avenue
                          Massey University
                          Palmerston North 4442
                          New Zealand
                          +64 6 356 9099
                          +64 6 951 6300
                          +64 0800 22 88 00

Palmerston North Taxis:   +64 6 355 5333
Reading List
CELSI
Cheung, M. J., Gibbons, H. M., Dragunow, M., & Faull, R. L. M. (2007). Tikanga in the
Laboratory: Engaging Safe Practise. MAI Review, (1), 1-7.

Du Plessis, R., Scott, A., Phillips, H., Cram, F., Tipene-Matua, B., Parsons, M., & Taupo, T.
(2004). The social, cultural, ethical and spiritual implications of genetic testing:
Preliminary findings (Constructive Conversations/Korero Whakaaetanga Research
Report No. 3). Christchurch, New Zealand: Social Science Research Centre, University of
Canterbury.                                    Retrieved                                from
http://www.conversations.canterbury.ac.nz/reportspapers.htm

Hudson, M., Milne, M., Reynolds, P., Russell, K., & Smith, B. (2010). Te Ara Tika - Guidelines
for Māori research ethics: A framework for researchers and ethics committee members.
Auckland, New Zealand: Health Research Council of New Zealand.

Merriman, T., & Cameron, V. (2006). Risk-taking: behind the warrior gene story. THE
NEW ZEALAND MEDICAL JOURNAL. Vol 120 No 1250 ISSN 1175 8716

Tipene-Matua, B., & Wakefield, B. (2007). Establishing a Māori ethical framework for
genetic reserach with Māori. In M. Henaghan (Ed.), Genes, society and the future (Vol. 3,
pp. 379-422). Wellington, New Zealand: Brookers Ltd.

Tupara, H. (2012). Ethics and health research: Decision making in Aotearoa New Zealand.
AJOB Primary Research, 3(4), 40-52.

P. L. Wilcox , J. A. Charity , M. R. Roberts , S. Tauwhare , B. Tipene‐Matua , I. Kereama‐
Royal , R. Hunter , H. M. Kani & P. Moke‐Delaney (2008) A values‐based process for cross‐
cultural dialogue between scientists and Māori, Journal of the Royal Society of New
Zealand, 38:3, 215-227, DOI: 10.1080/03014220809510555

HUMAN GENETICS
Buckley, HR., Tayles, N., Halcrow, SE., Robb, K.,& Fyfe, R. (2010). The People of the Wairua
Bar: a Re-examination. Journal of Pacific Archaeology 1:1.

Guilford, P., Hopkins, J., Harraway, J., McLeod, M., McLeod, N., Harawira, P., Taite, H.,
Scoular, R., Miller, A., & Reeve, AE. (1998). E-cadherin germline mutations in familial
gastric cancer. Nature, Vol 392: 402-405.

Gosling, AL., Matisoo-Smith, E., & Merriman, TR. (2013). Hyperuricaemia in the Pacific:
why the elevated serum urate levels? Rheumatology Int.

Gosling, AL, Buckley, HR., Matisoo-Smith, E., & Merriman, T. (2015). Pacific Populations,
Metabolic Disease and ‘Just-So Stories’: A Critique of the ‘Thrifty Genotype’ Hypothesis in
Oceania. Annals of Human Genetics, 00,1-11.
Knapp, M., Horsburgh, KA., Porst, S., Stanton, JA., Buckley, HR., Walter, RK., & Matisoo-
Smith EA. (2012). Complete mitochondrial DNA genome sequences from the first New
Zealanders. PNAS 109:45. www.pnas.org/cgi/doi/10.1073/pnas.1209896109

Manolio, TA. (2013). Bringing genome-wide association findings into clinical use. Natures
Review Genetics, vol 14, 549-558.

Manolio et al. (2015). Global implementation of genomic medicine: We are not alone.
Science Translational Medicine, Vol 7:290, 1-9.

Matisoo-Smith, EA., & Daugherty, C. Africa to Aotearoa: the longest migration. Journal of
the      Royal       Society       of        New       Zealand,       42:2,       87-92.
http://dx.doi.org/10.1080/03036758.2012.673495

PLANT GENETICS
Janick, J. (2013). Development of New World Crops by Indigenous Americans.
Hortscience, 48(4): 406-412.

Marshall et al. (2015) A DNA-based diagnostic for differentiating among New Zealand
endemic Podocarpus. Tree Genetics & Genomes Tree Genetics & Genomes vol 11:69

Shepherd LD, de Lange PJ, Cox S, McLenachan PA, Roskruge NR & Lockhart, P (2016)
Evidence of a strong domestication bottleneck in the recently cultivated New Zealand
endemic root crop, Arthropodium cirratum (Asparagaceae) PLoS ONE 11(3): e0152455
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Zealand Kamokamo (Cucurbita pepo, Cucurbitaceae), using mitochondrial DNA and
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Boocock, J., Chagné, D., Merriman, T. R., & Black, M. A. (2015). The distribution and impact
of common copy-number variation in the genome of the domesticated apple, Malus x
domestica Borkh. BMC Genomics, 16(1), 848. http://doi.org/10.1186/s12864-015-
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INDIGENOUS
Arbour, L., & Cook, D. (2006). DNA on Loan: Issues to Consider when Carrying Out Genetic
Research with Aboriginal Families and Communities. Community Genetics, 9: 153-160.

Taniguchi, N. K. , Taualii, M. , Maddock, J. (2012). A Comparative Analysis of Indigenous
Research Guidelines to Inform Genomic Research in Indigenous Communities. The
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http://ir.lib.uwo.ca/iipj/vol3/iss1/6
Hudson, M., Beaton, A., Milne, M., Port, W., Russell, K., Smith, B., Toki, V., Uerata, L., Wilcox,
P. (2016a). He Tangata Kei Tua: Guidelines for Biobanking with Māori. Māori and
Indigenous Governance Centre, Hamilton.

Hudson, M., Beaton, A., Milne, M., Port, W., Russell, K., Smith, B., Toki, V., Uerata, L., Wilcox,
P. (2016b). Te Mata Ira: Guidelines for Genomic Research with Māori. Māori and
Indigenous Governance Centre, Hamilton.

‘The Ancestors Speak: Ko‒iwi Tangata, Matauranga Māori and the Development of
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Katharina Ruckstuhl, Nancy Tayles, Hallie Buckley, Richard Bradley, Roger Fyfe and
Matapura Ellison

Claw, K., Anderson, M., Begay, R., Tsosie, K., Fox, K., Garrison, N. (2018). A framework for
enhancing ethical genomic research with Indigenous communities. Nature
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BIOINFORMATICS
Cadzow, M., Boocock, J., Nguyen, H. T., & Wilcox, P. (2014). A bioinformatics workflow for
detecting signatures of selection in genomic data. Frontiers in Genetics.
http://doi.org/10.3389/fgene.2014.00293

Nguyen, H. T., Merriman, T. R., & Black, M. A. (2014). The CNVrd2 package: measurement
of copy number at complex loci using high-throughput sequencing data. Frontiers in
Genetics, 5, 248. http://doi.org/10.3389/fgene.2014.00248
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