Instructions for Authors 2021 - In Vivo

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Instructions for Authors 2021 - In Vivo
in vivo 35: (2021)

Instructions for Authors 2021
General Policy. IN VIVO is a multidisciplinary journal designed to bring together original high quality works and reviews on
experimental and clinical biomedical research within the frames of human physiology, pathology and disease management. The topics
of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological
and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and
characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy,
Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis; Each article should include a concrete conclusion constituting
of a “new piece of knowledge” backed up by scientific evidence. 10. Retrospective studies and case reports. The principal aim of IN
VIVO is to provide for the prompt online publication for accepted articles, generally within 1-2 months from final acceptance.
   Manuscripts will be accepted on the understanding that they report original unpublished works that are not under consideration for publication
by another journal, and that they will not be published again in the same form. Αll authors should sign a submission letter confirming the
approval of their article contents. All material submitted to IN VIVO will be subject to peer-review, when appropriate, by two members of the
Editorial Board. All manuscripts submitted to IN VIVO are urgently treated with absolute confidence, with access restricted to the Managing
Editor, the journal’s secretary, the reviewers and the printers. The Editors reserve the right to improve manuscripts on grammar and style.
   The use of animals in biomedical research should take place under careful supervision of a person adequately trained in this field
and the animals must be treated humanely at all times. Such research should adhere to the Guiding Principles in the Care and Use of
Animals approved by the Council of the American Physiological Society.
   The Editors and Publishers of IN VIVO accept no responsibility for the contents and opinions expressed by the contributors. Authors
should warrantee due diligence in the creation and issuance of their work.

Open Access Policy. IN VIVO appears bimonthly as an online-only open access journal through the Stanford University HighWire
Press. Upon acceptance, Authors will be asked to pay an online publication fee of USD 800.00 (effective January 1, 2021) for articles
up to 8 online pages (including figures and tables). Each additional excess page will be charged USD 60.00. Color will not be charged.
Authors from developing countries may apply for a 25% discount after the acceptance of their paper. IN VIVO online will keep the
volume and issue numbers, as well as page numbering.

Copyright. Authors retain copyright. The unrestricted non-commercial use, distribution and reproduction in any medium of IN VIVO
articles for academic reasons is allowed, provided that the original work is properly cited. The Authors grant the permanent right to
the publisher to use any articles published in this journal without any restriction, including academic advertising purposes. PDF, XML
and html files of all articles published in IN VIVO are the property of the publisher.

Format. Two types of papers may be submitted: (i) Full papers containing completed original work, and (ii) review articles concerning
fields of recognisable progress. Papers should contain all essential data in order to make the presentation clear. Papers should be written
in clear, concise English. Spelling should follow that given in the “Shorter Oxford English Dictionary”.

Manuscripts. Manuscripts should be divided into the following sections: (a) First page including the title of the presented work [not
exceeding fifteen (15) words], full names and full postal addresses of all Authors, name of the Author to whom proofs are to be sent,
key words, an abbreviated running title, an indication “review”, “clinical”, “epidemiological”, or “experimental” study, and the date
of submission. (Note: The order of the Authors is not necessarily indicative of their contribution to the work. Authors may note their
individual contribution(s) in the appropriate section(s) of the presented work); (b) Abstract not exceeding 150 words, organized according
to the following headings: Background/Aim – Materials and Methods/Patients and Methods – Results – Conclusion; (c) Introduction;
(d) Materials and Methods/Patients and Methods; (e) Results; (f) Discussion; (g) Conflicts of Interest; (h) Authors’ contributions; (i)
Acknowledgements; (j) References. All pages must be numbered consecutively. Footnotes should be avoided. Review articles may
follow a different style according to the subject matter and the Author’s opinion. Review articles should not exceed 35 pages
(approximately 250 words per double-spaced typed page) including all tables, figures, and references.

Figures. All figures should appear at the end of the submitted document file. Once a manuscript is accepted all figures and graphs should be
submitted separately in either jpg, tiff or pdf format and at a minimum resolution of 300 dpi. Graphs must be submitted as pictures made
from drawings and must not require any artwork, typesetting, or size modifications. Symbols, numbering and lettering should be clearly legible.
The number and top of each figure must be indicated. Pages that include color figures are not subject to color charges.

Tables. All tables should appear at the end of the submitted document file. Once a manuscript is accepted, each table should be submitted
separately, typed double-spaced. Tables should be numbered with Roman numerals and should include a short title.
in vivo 35: (2021)

References. Authors must assume responsibility for the accuracy of the references used. Citations for the reference sections of submitted
works should follow the form below and must be numbered consecutively. In the text, references should be cited by number in
parenthesis. Examples: 1 Kenyon J, Liu W and Dalgleish A: Report of objective clinical responses of cancer patients to pharmaceutical-
grade synthetic cannabidiol. Anticancer Res 38(10): 5831-5835, 2018. PMID: 30275207. DOI: 10.21873/anticanres.12924. (PMIDs
and DOIs only if applicable). 2 McGuire WL and Chamnes GC: Studies on the oestrogen receptor in breast cancer. In: Receptors for
Reproductive Hormones. O’ Malley BW, Chamnes GC (eds.). New York, Plenum Publ Corp., pp 113-136, 1973. 3 Global Health
Estimates 2015: Disease Burden by Cause, Age, Sex, by Country and by Region, 2000-2015. Geneva, World Health Organisation,
2016. Available at http://www.who.int/healthinfo/global_burden_disease/estimates/en/index2.html. Last accessed on 3rd April 2018.
(The web address should link directly to the cited information and not to a generic webpage).

Nomenclature and Abbreviations. Nomenclature should follow that given in “Chemical Abstracts”, “Index Medicus”, “Merck Index”,
“IUPAC -IUB”, “Bergey’s Manual of Determinative Bacteriology”, The CBE Manual for Authors, Editors and Publishers (6th edition,
1994), and MIAME Standard for Microarray Data. Human gene symbols may be obtained from the HUGO Gene Nomenclature
Committee (HGNC) (http://www.gene.ucl.ac.uk/). Approved mouse nomenclature may be obtained from http://www.informatics.jax.org/.
Standard abbreviations are preferable. If a new abbreviation is used, it must be defined on first usage.

Clinical Trials. Authors of manuscripts describing clinical trials should provide the appropriate clinical trial number in the correct format
in the text.
   For International Standard Randomised Controlled Trials (ISRCTN) Registry (a not-for-profit organization whose registry is
administered by Current Controlled Trials Ltd.) the unique number must be provided in this format: ISRCTNXXXXXXXX (where
XXXXXXXX represents the unique number, always prefixed by “ISRCTN”). Please note that there is no space between the prefix
“ISRCTN” and the number. Example: ISRCTN47956475.
   For Clinicaltrials.gov registered trials, the unique number must be provided in this format: NCTXXXXXXXX (where XXXXXXXX
represents the unique number, always prefixed by “NCT”). Please note that there is no space between the prefix “NCT” and the
number. Example: NCT00001789.

Ethical Policies and Standards. IN VIVO agrees with and follows the “Uniform Requirements for Manuscripts Submitted to
Biomedical Journals” established by the International Committee of Medical Journal Editors in 1978 and updated in October 2001
(www.icmje.org). Microarray data analysis should comply with the “Minimum Information About Microarray Experiments (MIAME)
standard”. Specific guidelines are provided at the “Microarray Gene Expression Data Society” (MGED) website. Presentation of genome
sequences should follow the guidelines of the NHGRI Policy on Release of Human Genomic Sequence Data. Research involving human
beings must adhere to the principles of the Declaration of Helsinki and Title 45, U.S. Code of Federal Regulations, Part 46, Protection
of Human Subjects, effective December 13, 2001. Research involving animals must adhere to the Guiding Principles in the Care and
Use of Animals approved by the Council of the American Physiological Society. The use of animals in biomedical research should be
under the careful supervision of a person adequately trained in this field and the animals must be treated humanely at all times.
Research involving the use of human foetuses, foetal tissue, embryos and embryonic cells should adhere to the U.S. Public Law 103-
41, effective December 13, 2001.

Submission of Manuscripts. Please follow the Instructions for Authors regarding the format of your manuscript and references.
Manuscripts must be submitted only through our online submission system at: http://www.iiar-submissions.com/login.html
In case a submission is incomplete, the corresponding Author will be notified accordingly.
Questions regarding difficulties in using the online submission system should be addressed to: email: journals@iiar-anticancer.org

Galley Proofs. Unless otherwise indicated, galley proofs will be sent to the corresponding Author of the submission. Corrections of
galley proofs should be limited to typographical errors. Galley proofs should be returned corrected to the Editorial Office by email
within two days.

Specific information and additional instructions for Authors
 1. In Vivo (IV) will consider the publication of conference proceedings and/or abstracts provided that the material submitted fulfils
    the quality requirements and instructions of the journal, following the regular review process by two suitable referees.
 2. An acknowledgement of receipt, including the article number, title and date of receipt is sent to the corresponding author of each
    manuscript upon receipt. If this receipt is not received within 20 days from submission, the author should call or write to the Editorial
    Office to ensure that the manuscript (or the receipt) was not lost in the mail.
in vivo 35: (2021)

 3. Each manuscript submitted to IV is sent for peer-review in confidence to two suitable referees with the request to return the manuscript
    with their comments to the Editorial Office within 12 days from receipt. If reviewers need a longer time or wish to send the manuscript
    to another expert, the manuscript may be returned to the Editorial Office with a delay. All manuscripts submitted to IV, are treated
    in confidence, without access to any person other than the Managing Editor, the journal’s secretary, the reviewers and the printers.
 4. All accepted manuscripts are carefully corrected in style and language, if necessary, to make presentation clear. (There is no fee for this
    service). Every effort is made (a) to maintain the personal style of the author’s writing and (b) to avoid change of meaning. Authors will
    be requested to examine carefully manuscripts which have undergone language correction at the pre-proof or proof stage.
 5. Authors should pay attention to the following points when writing an article for IN VIVO:
    • The Instructions to Authors must be followed in every detail.
    • The presentation of the experimental methods should be clear and complete in every detail facilitating reproducibility by other scientists.
    • The presentation of results should be simple and straightforward in style. Results and discussion should not be combined into
       one section, unless the paper is short.
    • Results given in figures should not be repeated in tables.
    • Figures (graphs or photographs) should be prepared at a width of 8 or 17 cm with legible numbers and lettering.
    • Photographs should be clear with high contrast, presenting the actual observation described in the legend and in the text. Each
       legend should provide a complete description, being self-explanatory, including technique of preparation, information about the
       specimen and magnification.
    • Statistical analysis should be elaborated wherever it is necessary. Simplification of presentation by giving only numerical or %
       values should be avoided.
    • Fidelity of the techniques and reproducibility of the results, should be points of particular importance in the discussion section.
       Authors are advised to check the correctness of their methods and results carefully before writing an article. Probable or dubious
       explanations should be avoided.
    • Authors should not cite results submitted for publication in the reference section. Such results may be described briefly in the
       text with a note in parenthesis (submitted for publication by… authors, year).
    • References. Each article should address, list and discuss the entire spectrum of current publications relevant to its field.
    • By following these instructions, Authors will facilitate a more rapid review and processing of their manuscripts and will provide
       the readers with concise and useful papers.
 6. Following review and acceptance, a manuscript is examined in language and style, and galley proofs are rapidly prepared. Second
     proofs are not sent unless required.
 7. Authors should correct their galley proofs very carefully and preferably twice. An additional correction by a colleague always proves
     to be useful. Particular attention should be paid to chemical formulas, mathematical equations, symbols, medical nomenclature
     etc. Any system of correction marks can be used in a clear manner, preferably with a red pen. Additions or clarifications are allowed
     provided that they improve the presentation but do not bring new results (no fee).
 8. Articles submitted to IN VIVO may be rejected without review if:
    • they do not fall within the journal’s policy.
    • they do not follow the instructions for authors.
    • language is unclear.
    • results are not sufficient to support a final conclusion.
    • results are not objectively based on valid experiments.
    • they repeat results already published by the same or other authors before the submission to IV.
    • plagiarism is detected by plagiarism screening services.
       (Rejection rate (2020): 64%).
 9. Authors who wish to prepare a review should contact the Managing Editor of the journal in order to get confirmation of interest in
    the particular topic of the review and to allow programming of space availability. The expression of interest by the Managing Editor
    does not necessarily imply acceptance of the review by the journal.
10. Authors may inquire information about the status of their manuscript(s) by calling the Editorial Office at +30-22950-53389, Monday
    to Friday 9.00-16.00 (Athens time), or by sending an e-mail to journals@iiar-anticancer.org.
11. Authors who wish to edit a special issue on a particular topic should contact the Managing Editor.
    (This text is a combination of advice and suggestions contributed by Editors, Authors, Readers and the Managing Editor of IV).

Copyright© 2021 – International Institute of Anticancer Research (G.J. Delinasios). All rights reserved (including those of translation into
other languages). No part of this journal may be reproduced, stored in a retrieval system, or transmitted in any form or by any means,
electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher.
l Selection of Recent Articles
                                                                                                                                                                                     The Development of Next-generation PBMC Humanized Mice for
                                                                                                                                                                                     Preclinical Investigation of Cancer Immunotherapeutic Agents.
                                                                                                                                                                                     Y.M. MORILLON II, A. SABZEVARI, J. SCHLOM, J.W. GREINER
                                                                                                                                                                                     (Bethesda, MD, USA)
                                                                                                                                                                                     Human NK-92 Cells Function as Target Cells for Human NK Cells –
                                                                                                                                                                                     Implications for CAR NK-92 Therapies. H. BERGMAN, N. SISSALA,
  ANTICANCER RESEARCH                                                                                                                                                                H. HÄGERSTRAND, C. LINDQVIST (Turku, Finland)
                                                                                                                                                                                     Activation of Toll-Like Receptor 2 Promotes Proliferation of Human
                                                                                                                                                                                     Lung Adenocarcinoma Cells. A.K. GERGEN, P.D. KOHTZ,
  International Journal of Cancer Research and Treatment

                                                                                                                                                                                     A.L. HALPERN, A. LI, X. MENG, T.B. REECE, D.A. FULLERTON,
                                                                                                                                                              ISSN: 0250-7005

   Contents
                                                                                                                                                                                     M.J. WEYANT (Aurora, CO, USA)
   Review
                                                                                                                                                                                     Α Gemcitabine Plus 5-Fluorouracil Combination Inhibits Gastric-
                                                                                                                                                                                     Cancer Liver Metastasis in a PDOX Model: A Novel Treatment
   Current Treatment of Colorectal Liver Metastasis as a Chronic Disease. N.M. DÖRR, M. BARTELS, M.H.

                                                                                                                                                                                     Strategy. N. SUGISAWA, H. NISHINO, T. HIGUCHI, J.H. PARK,
   MORGUL (Leipzig; Münster, Germany).........................................................................................................................                  1

   Experimental Studies

                                                                                                                                                                                      J. YAMAMOTO, Y. TASHIRO, K. KAWAGUCHI, M. BOUVET,
   SAHA and EGCG Promote Apoptosis in Triple-negative Breast Cancer Cells, Possibly Through the Modulation
   of cIAP2. K.L. STEED, H.R. JORDAN, T.O. TOLLEFSBOL (Birmingham, AL, USA) ..........................................                                                          9

                                                                                                                                                                                     M. UNNO, R.M. HOFFMAN (San Diego, CA, USA; Sendai, Japan)
   Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African
   Americans. M. ABBAS, T. MASON, A. IBAD, M. KHRAIWESH, V. APPREY, Y. KANAAN, B. WILSON, G.

                                                                                                                                                                                     Expression of ATP-binding Cassette Transporter 11 (ABCC11) Protein
   DUNSTON, L. RICKS-SANTI, H. BRIM (Washington, DC; Silver Spring, MD; Hampton, VA, USA).................                                                                    27

   High Expression of c-Met, PKCλ and ALDH1A3 Predicts a Poor Prognosis in Late-stage Breast Cancer. H.

                                                                                                                                                                                     in Colon Cancer. Y. YAMADA, K. YOSHIMATSU, H. YOKOMIZO,
   MOTOMURA, Y. NOZAKI, C. ONAGA, A. OZAKI, S. TAMORI, T.-A. SHIINA, S. KANAI, C. OHIRA, Y.
   HARA, Y. HARADA, R. TAKASAWA, T. HANAWA, S.-I. TANUMA, Y. MANO, T. SATO, K. SATO, K.
                                                                                                                                                                              35

                                                                                                                                                                                     S. OKAYAMA, S. SHIOZAWA (Tokyo, Japan)
   AKIMOTO (Chiba, Japan)...............................................................................................................................................

   Targeting Fibroblast Growth Factor Receptor (FGFR) and Phosphoinositide 3-kinase (PI3K) Signaling Pathways
   in Medulloblastoma Cell Lines. S. HOLZHAUSER, M. LUKOSEVICIUTE, T. ANDONOVA, R.G. URSU, T.

                                                                                                                                                                                     Genomic Database Analysis for Head and Neck Cancer Prevention
   DALIANIS, M. WICKSTRÖM, O.N. KOSTOPOULOU (Stockholm, Sweden; Iasi, Romania) .............................                                                                  53

   Cisplatin Induced the Expression of SEI1 (TRIP-Br1) Oncogene in Human Oral Squamous Cancer Cell Lines.

                                                                                                                                                                                     Targets: MTOR Signal Transduction Pathway. C. KOENIGSBERG,
   J. LI, Z. VANGUNDY, M. POI (Columbus, OH, USA).................................................................................................                            67

                                                                                                                                                                                     F.G. ONDREY (Minneapolis, MN, USA)
                                                                                                                                              Contents continued on the back cover

                                                                                                                                                                                     Presence of the Transmembrane Protein Neuropilin in Cytokine-
                                                                                                                                                                                     induced Killer Cells. E.V. DÍEZ GARCÍA DE OLALLA,
          ISSN (online): 1791-7530 / ISSN (print): 0250-7005

                                                                                                                                                                                     F. GAROFANO, H. WEIHER, M. MUDERS, S. FÖRSTER,
                                                                                                                                                                                     I.G.H. SCHMIDT-WOLF (Bonn; Rheinbach, Germany)
                                                                                                                                                                                     Association of Caspase-8 Genotypes With the Risk for Nasopharyngeal
Generaly Policy
l ANTICANCER RESEARCH is an                                                                                                                                                          Carcinoma in Taiwan. L.-C. SHIH, C.-W. TSAI, W.-S. CHANG,
                                                                                                                                                                                     T.-C. SHEN, Y.-C. WANG, J.-S. YANG, M.-L. LIN, Z.-H. WANG,
                                                                                                                                                                                     D.-T. BAU (Taichung, Taiwan, ROC)
  independent international forum

                                                                                                                                                                                     Mogamulizumab Plus EPOCH Therapy for Patients With Newly
  devoted to the rapid publication of

                                                                                                                                                                                     Diagnosed Aggressive Adult T-cell Leukemia/lymphoma. T. JO,
  original high quality articles and

                                                                                                                                                                                     K. MATSUZAKA, H. SHIOYA, H. TOMINAGA, T. SAKAI,
  reviews on all aspects of experimental
                                                                                                                                                                                     Y. KANEKO, S. HAYASHI, M. MATSUO, J. TAGUCHI, K. ABE,
  and clinical oncology. Prompt
                                                                                                                                                                                     K. SHIGEMATSU, R. KUBOTA-KOKETSU (Nagasaki; Osaka, Japan)
  evaluation of all submitted articles in
                                                                                                                                                                                     WNT Signaling Driven by R-spondin 1 and LGR6 in High-grade
  confidence and rapid publication
                                                                                                                                                                                     Serous Ovarian Cancer. S. LEE, J. JUN, W.J. KIM, P. TAMAYO,
  within 1-2 months from acceptance
  are guaranteed.                                                                                                                                                                    S.B. HOWELL (Seoul, Republic of Korea; San Diego, CA, USA)
l ANTICANCER RESEARCH is published                                                                                                                                                   Characterization of a Novel Barbituric Acid and Two Thiobarbituric
                                                                                                                                                                                     Acid Compounds for Lung Cancer Treatment. S.Y. LEE,
                                                                                                                                                                                     B. SLAGLE-WEBB, A.K. SHARMA, J.R. CONNOR (Hershey, PA, USA)
  monthly by the International Institute

                                                                                                                                                                                     An Autocrine Role for CXCL1 in Progression of Hepatocellular
  of Anticancer Research and is available

                                                                                                                                                                                     Carcinoma. K.J.V. DAHLQUIST, L.C. VOTH, A.J. FEE,
  online with Stanford University
                                                                                                                                                                                     A.K. STOECKMAN (Saint Paul, MN, USA)
  HighWire Press.
l Editorial Office: International Institute                                                                                                                                          Apoptosis-related Proteins Are Altered by Selective Tyrosine Kinase
                                                                                                                                                                                     Inhibitors and Everolimus in HPV-dependent SCC. R. BIRK,
                                                                                                                                                                                     A. SCHELL, C. ADERHOLD, S. HOCH, L. HUBER, C.E.
  of Anticancer Research, 1st km

                                                                                                                                                                                     MUELLER, A. LAMMERT, C. SCHERL, N. ROTTER, J.U.
  Kapandritiou-Kalamou Rd., P.O. Box

                                                                                                                                                                                     SOMMER, B. KRAMER (Marburg; Mannheim; Wuppertal, Germany)
  22, Kapandriti, Attiki 19014, Greece.

                                                                                                                                                                                     Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in
  Tel: +30 22950 52945, Fax: +30

                                                                                                                                                                                     Leukemia Cells Βut Not in Normal Hematopoietic Cells. A. THADI,
  22950 53389.
                                                                                                                                                                                     L. LEWIS, E. GOLDSTEIN, A. AGGARWAL, M. KHALILI,
                                                                                                                                                                                     L. STEELE, B. POLYAK, S. SEYDAFKAN, M.H. BLUTH,
  U.S. Branch: Anticancer Research

                                                                                                                                                                                     K.A. WARD, M. STYLER, P.M. CAMPBELL, M.R. PINCUS,
  Inc., USA, 111 Bay Avenue,
                                                                                                                                                                                     W.B. BOWNE (Philadelphia, PA; Brooklyn, NY; Detroit, MI, USA)
  Highlands, NJ, USA.
l E-mail:journals@iiar-anticancer.org; IIAR                                                                                                                                          Phase I Study of LFA102 in Patients With Advanced Breast Cancer
  WEBSITES: www.iiar-anticancer.org and                                                                                                                                              or Castration-resistant Prostate Cancer. H. MINAMI, Y. ANDO,
                                                                                                                                                                                     K. TAMURA, T. TAJIMA, R. ISAACS (Kobe; Nagoya; Tokyo, Japan;
                                                                                                                                                                                     East Hanover, NJ, USA)
  www.iiarjournals.org
l Selection of Recent Articles
                                                                               Micro RNAs Promoting Growth and Metastasis in Preclinical In Vivo
                                                                               Models of Subcutaneous Melanoma. U.H. WEIDLE, S. AUSLÄNDER,
   CANCER
                                                                               U. BRINKMANN (Penzberg, Germany)
   GENOMICS &
   PROTEOMICS
                                                                               Differential Proteomic Analysis of Hepatocellular Carcinomas from
                                                                               Ppp2r5d Knockout Mice and Normal (Knockout) Livers. C. LAMBRECHT,
                                                                               G.B. FERREIRA, J.D. OMELLA, L. LIBBRECHT, R. DE VOS, R.
   ISSN (online): 1790-6245

                                                                               DERUA, C. MATHIEU, L. OVERBERGH, E. WAELKENS, V. JANSSENS
                                                                               (Leuven; Brussels, Belgium)
                                                                               Stem-like Cells from Invasive Breast Carcinoma Cell Line MDA-MB-231
                                                                               Express a Distinct Set of Eph Receptors and Ephrin Ligands. M. LUCERO,
                                                                               J. THIND, J. SANDOVAL, S. SENAATI, B. JIMENEZ, R.P. KANDPAL
                                                                               (Pomona, CA, USA)
                                                                               Circulating Tumor DNA in Biliary Tract Cancer: Current Evidence and
                                                                               Future Perspectives. A. RIZZO, A.D. RICCI, S. TAVOLARI, G. BRANDI
                                                                               (Bologna, Italy)
                                                                               Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-
                                                                               null Cancer Cells Established by Double Genetic Knockout of Lactate
                                                                               Dehydrogenase A/B or Glucose-6-Phosphate Isomerase. E. MAZZIO,
                                                                               R. BADISA, N. MACK, S. CASSIM, M. ZDRALEVIC, J. POUYSSEGUR,
   Published by the International Institute of Anticancer Research

                                                      Online ISSN: 1790-6245   K.F.A. SOLIMAN (Tallahassee, FL, USA; Monaco, Monaco; Nice, France)
                                                                               TIP60/P400/H4K12ac Plays a Role as a Heterochromatin Back-up Skeleton
General Policy                                                                 in Breast Cancer. M. IDRISSOU, T. BOISNIER, A. SANCHEZ, F.Z.H.
                                                                               KHOUFAF, F. PENAULT-LLORCA, Y.-J. BIGNON, D. BERNARD-
l CANCER GENOMICS & PROTEOMICS                                                 GALLON (Clermont-Ferrand, France)
  (CGP) welcomes submissions of original high
                                                                               STRA6 Expression Serves as a Prognostic Biomarker of Gastric Cancer.
  quality articles and reviews on all aspects of
                                                                               S. NAKAMURA, M. KANDA, D. SHIMIZU, K. SAWAKI, C. TANAKA,
  the application of genomic and proteomic
                                                                               N. HATTORI, M. HAYASHI, S. YAMADA, G. NAKAYAMA, K. OMAE,
  technologies to experimental and clinical                                    M. KOIKE, Y. KODERA (Nagoya; Fukushima, Japan)
  cancer research. The journal’s scientific
                                                                               Expression Patterns of CD44 and AREG Under Treatment With Selective
  spectrum includes: (a) molecular causes of
                                                                               Tyrosine Kinase Inhibitors in HPV+ and HPV− Squamous Cell Carcinoma.
  carcinogenesis, cancer progression and
                                                                               B. KANSY, C. ADERHOLD, L. HUBER, S. LUDWIG, R. BIRK,
  metastasis; (b) structural and functional
                                                                               A. LAMMERT, S. LANG, N. ROTTER, B. KRAMER (Essen; Mannheim;
  aspects of genes in the cancer cell; (c)
                                                                               Marburg, Germany)
  advances in genomic and proteomic
                                                                               Chromobox 2 Expression Predicts Prognosis After Curative Resection of
  technologies applicable to cancer research; (d)
                                                                               Oesophageal Squamous Cell Carcinoma. S. UEDA, M. KANDA, Y. SATO,
  anticancer drug design and drug development.
                                                                               H. BABA, S. NAKAMURA, K. SAWAKI, D. SHIMIZU, S. MOTOYAMA,
  A main aim of CGP is to ensure the prompt
                                                                               T. FUJII, Y. KODERA, S. NOMOTO (Nagoya; Akita; Toyama, Japan)
  and confidential review, and rapid publication
  of original works and reviews, generally                                     Fusion of the Lumican (LUM) Gene With the Ubiquitin Specific Peptidase 6
  within 1-3 months from submission.                                           (USP6) Gene in an Aneurysmal Bone Cyst Carrying a t(12;17)(q21;p13)
                                                                               Chromosome Translocation. I. PANAGOPOULOS, L. GORUNOVA,
l CGP is published bimonthly by the                                            K. ANDERSEN, I. LOBMAIER, M. LUND-IVERSEN, F. MICCI, S. HEIM
  International Institute of Anticancer                                        (Oslo, Norway)
  Research (IIAR) and is available online only                                 Influence of Concurrent Mutations on Overall Survival in EGFR-mutated
  and open access with Stanford University                                     Non-small Cell Lung Cancer. M. CHEVALLIER, P. TSANTOULIS, A.
  HighWire Press. For more information please                                  ADDEO, A. FRIEDLAENDER (Geneva, Switzerland)
  visit our website www.cgp.iiarjournals.org.                                  Long Noncoding RNA ANROC on the INK4 Locus Functions to Suppress
l Editorial Office: International Institute of                                 Cell Proliferation. Y. KOTAKE, T. TSURUDA (Fukuoka, Japan)
  Anticancer Research, 1st km Kapandritiou-                                    The KDR (VEGFR-2) Genetic Polymorphism Q472H and c-KIT
  Kalamou Rd., P.O. Box 22, Kapandriti, Attiki                                 Polymorphism M541L Are Associated With More Aggressive Behaviour in
  19014, Greece. Tel: +30 22950 52945, Fax:                                    Astrocytic Gliomas. N. ZAMAN, S.S. DASS, P.D. PARCQ,
  +30 22950 53389.                                                             S. MACMAHON, L. GALLAGHER, L. THOMPSON, J.S. KHORASHAD,
                                                                               C. LIMBÄCK-STANIC (London, UK)
   U.S. Branch: Anticancer Research Inc., USA,
                                                                               KIF15 Εxpression in Τumor-associated Μonocytes Ιs a Prognostic
   111 Bay Avenue, Highlands, NJ, USA.
                                                                               Biomarker in Hepatocellular Carcinoma. A. KITAGAWA, T. MASUDA, J.
l E-mail: journals@iiar-anticancer.org; IIAR                                   TAKAHASHI, T. TOBO, M. NODA, Y. KURODA, Q. HU, Y. KOUYAMA,
  WEBSITES: www.iiar-anticancer.org and                                        Y. KOBAYASHI, S. KURAMITSU, K. SATO, A. FUJII, Y. YOSHIKAWA,
  www.iiarjournals.org                                                         H. WAKIYAMA, D. SHIMIZU, Y. TSURUDA, H. EGUCHI, Y. DOKI,
                                                                               M. MORI, K. MIMORI (Oita; Osaka; Fukuoka, Japan)
Contents continued

Transanal Endoscopic Microsurgery (TEMS) for Rectal Cancer: Patient Decision-making, Postoperative
Experience and Quality of Life. A. KORELI, G. BRIASSOULIS, M. SIDERIS, A. PHILALITHIS, S.
PAPAGRIGORIADIS (Heraklion; Athens, Greece; London, UK)...........................................................                                                   1235

Effectiveness of Vintage Hormone Therapy as Alternative Androgen Deprivation Therapy for Non-
metastatic Castration-resistant Prostate Cancer. H. IWAMOTO, H. KANO, T. SHIMADA, R. NAITO, T.
MAKINO, S. KADAMOTO, H. YAEGASHI, K. SHIGEHARA, K. IZUMI, Y. KADONOA, A. MIZOKAMI
(Kanazawa, Japan)...........................................................................................................................................         1247

Efficacy and Safety of Paclitaxel Combined With Cetuximab for Head and Neck Squamous Cell Carcinoma.
T. OKADA, I. OKAMOTO, H. SATO, T. ITO, K. MIYAKE, K. TSUKAHARA (Tokyo, Japan)........................                                                                1253

Impact of Colon Cancer Location on the Prognostic Significance of Nutritional Indexes and Inflammatory
Markers. T. HAYAMA, T. OZAWA, K. ASAKO, R. KONDO, K. ONO, Y. OKADA, M. TSUKAMOTO, Y.
FUKUSHIMA, R. SHIMADA, K. NOZAWA, K. MATSUDA, S. FUJII, T. FUKAGAWA, Y. HASHIGUCHI
(Tokyo, Japan)..............................................................................................................................................         1261

Daily Triglyceride Output Volume as an Early Predictor for Chyle Leak Following Pancreaticoduodenectomy.
T. SAKAMOTO, N. OKUI, F. SUZUKI, R. HAMURA, Y. SHIRAI, K. HARUKI, K. FURUKAWA, T. IKEGAMI
(Saku; Tokyo, Japan) .............................................................................................................................................   1271

Response to Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer: The Role of Immune-
related Factors. I. PALAIA, F. TOMAO, A. DI PINTO, A. PERNAZZA, G. SANTANGELO, N.
D’ALESSANDRIS, L. MANGANARO, A. ARNO, V. DI DONATO, G. PERNIOLA, C. DELLA ROCCA,
P.B. PANICI (Rome; Milan, Italy)...........................................................................................................                          1277

Articles on Covid-19

Τhe Experience of Greece as a Model to Contain COVID-19 Infection Spread. G.J. DELINASIOS,
P.C. FRAGKOU, A.M. GKIRMPA, G. TSANGARIS, R.M. HOFFMAN, A.K. ANAGNOSTOPOULOS
(Kapandriti; Athens, Greece; San Diego, CA, USA) ..............................................................................                                      1285

Selection of the Appropriate Control Group Is Essential in Evaluating the Cytokine Storm in COVID-
19. A.G. VASSILIOU, I. DIMOPOULOU, E. JAHAJ, C. KESKINIDOU, Z. MASTORA, S.E. ORFANOS,
A. KOTANIDOU (Athens, Greece) .........................................................................................................                              1295

Colorectal Cancer Surgery During the COVID-19 Pandemic: A Single Center Experience. D. PERTILE,
M. GIPPONI, A. APRILE, P. BATISTOTTI, C.M. FERRARI, A. MASSOBRIO, D. SORIERO, L. EPIS,
S. SCABINI (Genoa, Italy)......................................................................................................................                      1299

The Impact of COVID-19 Infection on the Postoperative Outcomes in Pancreatic Cancer Patients. N.
BACALBASA, C. DIACONU, C. SAVU, C. SAVU, O. STIRU, I. BALESCU (Bucharest, Romania) ............                                                                      1307
Contents continued

Assessment of Pain, Acceptance of Illness, Adaptation to Life, and Strategies of Coping With the Disease,
in Patients With Bladder Cancer. U. RELIGIONI, A. CZERW, A. DEPTALA (Warsaw, Poland) ..................                                                      1157

Association of the Modified ALBI Grade With Endoscopic Findings of Gastroesophageal Varices. Y.
MIYAMOTO, H. ENOMOTO, H. NISHIKAWA, T. NISHIMURA, Y. IWATA, S. NISHIGUCHI, H.
IIJIMA (Nishinomiya; Hyogo; Osaka, Japan).........................................................................................                           1163

Outcome of Radiation Therapy for Stage IVB Uterine Cervical Cancer With Distant Lymph Nodes
Metastases; Sequential Irradiation for Distant Lymph Nodes Metastases. Y. MUKAI, N.R. YOKOTA, M.
SUGIURA, T. MIZUSHIMA, R. TANIUCHI, Y. IMAI, K. HASHIMOTO, Y. TABUCHI, E. MIYAGI, M.
HATA (Yokohama, Japan).....................................................................................................................                  1169

Crossed Cerebellar Diaschisis in Alzheimer’s Disease Detected by Arterial Spin-labelling Perfusion MRI.
A. HERTEL, H. WENZ, M. AL-ZGHLOUL, L. HAUSNER, L. FRÖLICH, C. GRODEN, A. FÖRSTER
(Mannheim, Germany) ...........................................................................................................................              1177

Progression After Molecular Targeted Agents: Hepatic Arterial Changes and Transarterial
Chemoembolization in Hepatocellular Carcinoma. N. MATSUDA, N. IMAI, T. KUZUYA, K. YAMAMOTO,
T. ITO, Y. ISHIZU, T. HONDA, M. ISHIGAMI, M. FUJISHIRO (Aichi, Japan) ...........................................                                            1185

Left Hepatectomy Through Double Approach and Total Vascular Exclusion for Giant Left Lobe
Hepatocarcinoma. N. BACALBASA, I. BALESCU, S. DIMA, L. ALECU, I. POPESCU (Bucharest,
Romania) ................................................................................................................................................    1191

Comparison of Central Venous Port Procedures Between Puncture vs. Cut-down and Residents vs.
Senior Surgeons. R. OTSUBO, H. YANO, M. MATSUMOTO, A. TANAKA, T. NONAKA, S. HIDAKA,
K. MATSUMOTO, T. TSUCHIYA, S. SATO, T. NAGAYASU (Nagasaki, Japan) .................................                                                          1197

Grade 1 Endometrioid Carcinoma With an Area of Serous Carcinoma Less than 5% Is More
Aggressive than Stage IA Pure-type Grade 1 Endometrioid Carcinoma. M. MIYAMOTO, H. TSUDA,
A. SUGIURA, T. KITA, Y. KATAOKA, K. ISHII, K. KUDO, H. MATSUURA, H. ISHIBASHI, H.
IWAHASHI, T. HADA, R. SUZUKI, M. TAKANO (Saitama; Nara; Tokyo, Japan) ...............................                                                        1205

Efficacy of Paclitaxel-based Chemotherapy After Progression on Nivolumab for Head and Neck
Cancer. Y. SATO, N. FUKUDA, Y. FUJIWARA, X. WANG, T. URASAKI, A. OHMOTO, K. NAKANO,
M. ONO, J. TOMOMATSU, H. MITANI, S. TAKAHASHI (Tokyo, Japan) ...........................................                                                     1211

Incidental Gallbladder Cancer on Cholecystectomy: Strategy for Re-resection of Presumed Benign
Diseases from a Retrospective Multicenter Study by the Yokohama Clinical Oncology Group. R.
MATSUYAMA, K. MATSUO, R. MORI, M. SUGITA, N. YAMAGUCHI, T. KUBOTA, K. KAMEDA, Y.
MOCHIZUKI, R. TAKAGAWA, T. KADOKURA, G. MATSUDA, N. KAMIYA, I. ENDO (Yokohama;
Fujisawa; Yokosuka; Ito, Japan) ............................................................................................................                 1217

Risk Factors for Postoperative Liver Enzyme Elevation After Laparoscopic Gastrectomy for Gastric
Cancer. A. SANO, K. SAITO, K. KURIYAMA, N. NAKAZAWA, Y. UBUKATA, K. HARA, M. SAKAI,
K. OGATA, T. FUKASAWA, M. SOHDA, M. FUKUCHI, H. NAITOH, K. SHIRABE, H. SAEKI
(Gunma, Japan) .....................................................................................................................................         1227
                                                                                                                            Contents continued on the preceding page
Contents continued

The Economic Burden of Postoperative Complications Predicted by the Comprehensive Complication
Index® in Patients Undergoing Elective Major Hepatopancreaticobiliary Surgery for Malignancy – A
Prospective Cost Analysis. D.A. RAPTIS, T. HANNA, N. MACHAIRAS, T. OWEN, D. DAVIES, G.K.
FUSAI (London, UK) ..............................................................................................................................            1065

Synovial Alpha-defensin at Reimplantation in Two-stage Revision Arthroplasty to Rule Out Persistent
Infection. C. BIELEFELD, H. ENGLER, M. JÄGER, A. WEGNER, D. WASSENAAR, A. BUSCH
(Mülheim an der Ruhr; Essen, Germany)...............................................................................................                         1073

Prognostic Evaluation of the Site of Invasion in Pathological Stage T3a Renal Cell Carcinoma. G.-S.
LAI, J.-R. LI, S.-S. WANG, C.-S. CHEN, C.-K. YANG, S.-C. HUNG, C.-L. CHENG, Y.-C. OU, K.-Y.
CHIU (Chiayi; Taichung; Nantou, Taiwan, ROC)..................................................................................                               1083

Prognostic Significance of the Immunological Indices in Patients Who Underwent Complete Resection
of Pulmonary Metastases of Colorectal Cancer. Y. OKAZAKI, M. SHIBUTANI, E. WANG, H.
NAGAHARA, T. FUKUOKA, Y. ISEKI, S. KASHIWAGI, H. TANAKA, K. MAEDA, K. HIRAKAWA, M.
OHIRA (Osaka, Japan)...........................................................................................................................              1091

Three-month Prostate-specific Antigen Level After Androgen Deprivation Therapy Predicts Survival
in Patients With Metastatic Castration-sensitive Prostate Cancer. N. FUJIMOTO, M. SHIOTA, T.
MATSUKAWA, A. MINATO, I. TOMISAKI, R. OHNISHI, M. ETO (Kitakyushu; Fukuoka, Japan) ......                                                                    1101

Pelvic Insufficiency Fractures in Cervical Cancer After Radiation Therapy: A Meta-Analysis and
Review. Y.K. CHUNG, Y.-K. LEE, B.-H. YOON, D.H. SUH, K.-H. KOO (Goyang; Seongnam; Seoul,
Republic of Korea)..................................................................................................................................         1109

Outcome After Radiation Therapy in Canine Intracranial Meningiomas or Gliomas. T. RODRIGUES
MAGALHÃES, J. BENOÎT, S. NÉČOVÁ, S. NORTH, F.L. QUEIROGA (Vila Real; Porto, Portugal;
Essex, UK) ..............................................................................................................................................    1117

Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Differentiated Thyroid Carcinoma
Having Distant Metastasis: A Comparison With Thyroglobulin-doubling Rate and Tumor Volume-
doubling Rate. Y. ITO, N. ONODA, M. KIHARA, A. MIYA, A. MIYAUCHI (Kobe, Japan) ..................                                                            1125

Neutrophil-to-Lymphocyte Ratio After Definitive Concurrent Chemoradiotherapy Predicts Survival in
Patients With Esophageal Squamous Cell Carcinoma. H.K. KOH, Y. PARK, T. KOO, H.J. PARK, M.Y.
LEE, A.R. CHANG, S. HONG, H. BAE (Seoul; Anyang, Republic of Korea).......................................                                                   1133

Single Short Retention Instillation of Pirarubicin Prevents Intravesical Recurrence of Low-risk Non
Muscle Invasive Bladder Cancer. S. KAGEYAMA, K. MAEDA, S. KUBOTA, T. YOSHIDA, T.
OSAFUNE, Y. ARAI, H. SOGA, Z. NISHIKAWA, Y. SAKANO, K. TAKIMOTO, C.J. KIM, T. CHANO,
A. KAWAUCHI (Shiga; Kyoto, Japan) ...................................................................................................                        1141

Regimen of 5-Fluorouracil and Cisplatin Increases the Incidence of Extravasation in Patients
Undergoing Chemotherapy. H. TAGASHIRA, Y. IZUSHI, T. IKUTA, Y. KOIKE, Y. KITAMURA, H.
YAMAMOTO (Okayama; Ehime, Japan) ..............................................................................................                              1147

Intra-abdominal Desmoid-Type Fibromatosis Mimicking Diverticulitis With Abscess: A Case Report.
S. OMORI, S. ITO, K. KIMURA, T. HIGASHI, K. OHGAKI, S. MAEHARA, T. NAKAMURA, T, OHGA,
E. ADACHI, Y. IKEDA, Y. MAEHARA (Fukuoka, Japan) .....................................................................                                       1151
                                                                                                                            Contents continued on the preceding page
Contents continued

Cytotoxic T-lymphocyte Antigen-4 (CTLA-4) Gene Polymorphism (rs3087243) Is Related to Risk and
Survival in Patients With Colorectal Cancer. S.V. NGUYEN, L. SHAMOUN, K. LANDERHOLM, R.E.
ANDERSSON, D. WAGSATER, J. DIMBERG (Danang, Vietnam; Jönköping; Uppsala; Linköping,
Sweden)..................................................................................................................................................       969

Retrospective Comparison of mFOLFOXIRI With XELOX/SOX as Neoadjuvant Chemotherapy for Locally
Advanced Rectal Cancer. H. KODAMA, T. TERAZAWA, Y. ISHIZUKA, H. YUKAMI, M. AOKI, T.
MIYAMOTO, T. YAMAGUCHI, F. SHIMAMOTO, T. KII, M. GOTO, H. HAMAMOTO, W. OSUMI, M.
YAMAMOTO, K. TANAKA, J. OKUDA, K. UCHIYAMA, K. HIGUCHI (Osaka, Japan)................................                                                           977

Risk Factors for Lymph Node Metastasis in Pathological T1b Colorectal Cancer. A. NAITO, K.
IWAMOTO, M. OHTSUKA, M. IMASATO, Y. NAKAHARA, M. MIKAMORI, K. FURUKAWA, J.
MOON, T. ASAOKA, K. KISHI, H. AKAMATSU (Osaka, Japan) ..........................................................                                                987

Weak-evidence Fusion Candidates Detected by a FusionPlex Assay Using the Ion Torrent System. S.
FUJITA, K. MASAGO, E. SASAKI, S. TSUKUSHI, Y. HORIO, H. KURODA, T. HIDA (Nagoya; Kobe,
Japan).....................................................................................................................................................     993

The Controlling Nutritional Status CONUT Score in Patients With Advanced Bladder Cancer After
Radical Cystectomy. Y. NEMOTO, T. KONDO, H. ISHIHARA, T. TAKAGI, H. FUKUDA, K.
YOSHIDA, J. IIZUKA, H. ISHIDA, K. TANABE (Tokyo, Japan) ...........................................................                                             999

An Observational Study on Breast Cancer Survival and Lifestyle Related Risk Factors. A. KREKLAU, I.
NEL, S. KASIMIR-BAUER, R. KIMMIG, A.C. FRACKENPOHL, B. AKTAS (Leipzig; Essen, Germany)......                                                                   1007

Impact of Smoking on the Survival of Patients With High-risk HPV-positive HNSCC: A Meta-analysis. M.
ALOTAIBI, V. VALOVA, T. HÄNSEL, C. STROMBERGER, G. KOFLA, H. OLZE, I. PIWONSKI, A.
ALBERS, S. OCHSENREITHER, A. COORDES (Berlin, Germany; Riyadh, Kingdom of Saudi Arabia) ......                                                                 1017

Implications of Preoperative Transbronchial Lung Biopsy for Non-small Cell Lung Cancer Less than 3-cm.
M. YASUKAWA, T. KAWAGUCHI, M. KIMURA, T. TOJO, S. TANIGUCHI (Nara; Osaka, Japan)..........                                                                     1027

The Advantage of Pinpoint Camera System With Indocyanine Green for Sentinel Lymph Node
Micrometastasis Detection in Low Risk Endometrial Cancer. A. LAZARIDIS, S. KOGEORGOS, P.
BALINAKOS, K. PAVLAKIS, T. GAVRESEA, G. PISTOFIDIS (Athens, Greece; London, UK) ............                                                                   1033

Neo-Bioscore in Guiding Post-surgical Therapy in Patients With Triple-negative Breast Cancer Who
Received Neoadjuvant Chemotherapy. Y. HASEGAWA, N. MATSUBARA, T. KOGAWA, Y. NAITO,
K. HARANO, A. HOSONO, T. ONISHI, T. HOJO, M. SHIMOKAWA, T. MUKOHARA (Kashiwa; Ube,
Japan).....................................................................................................................................................    1041

Perineural Invasion Correlates With Common Pathological Variables and Clinical Outcomes of Patients
With Squamous Cell Carcinoma of the Vulva Treated With Primary Radical Surgery and Inguinal-
femoral Lymphadenectomy. A. GADDUCCI, S. PISTOLESI, S. COSIO, C. COMUNALE, A.
FANUCCHI, A.G. NACCARATO (Pisa, Italy) ........................................................................................                                1051

Sorafenib and Lenvatinib Treatment for Metastasis/Recurrence of Radioactive Iodine-refractory
Differentiated Thyroid Carcinoma. Y. ITO, N. ONODA, T. KUDO, H. MASUOKA, T. HIGASHIYAMA,
M. KIHARA, A. MIYA, A. MIYAUCHI (Kobe, Japan) ............................................................................                                     1057
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Contents continued

Bone Morphogenetic Protein 7 Expression in Alveolar Bone Addition With Autologous Blood, Lyophilized

C.-S. LAZĂR, A.S. ȘOVREA, A.-M. CONSTANTIN, G. DOGARU (Cluj-Napoca, Romania) ....................
Bone and Atelocollagen. B.-C. ALEXANDRU, M. POPA, L. OANA, C.I. BONDOR, C.RMEN GEORGIU,
                                                                                                                                                                     871

Vignacyanidin Polyphenols Isolated from Vigna Angularis Bean Promote Osteoblast Differentiation. T.
ROJASAWASTHIEN, T. SHIRAKAWA, A. WASHIO, T. TSUJISAWA, T. MATSUBARA, A. INOUE, U.
TAKAHAMA, K. NAKASHIMA, S. KOKABU (Kitakyushu, Japan).........................................................                                                       883

Clinical Studies

Surgery for Peripheral Nerve Sheath Tumours of the Buttocks, Legs and Feet in 90 Patients With
Neurofibromatosis Type 1. R.E. FRIEDRICH, C.T. TUZCU (Hamburg, Germany) ..............................                                                               889

A Finnish Version of RAND-36-Item Health Survey Versus Structured Interview 8 Years Postoperatively.
I. SAIMANEN, V. KUOSMANEN, J. HARJU, T. SELANDER, S. ASPINEN, M. ESKELINEN (Kuopio,
Finland) .........................................................................................................................................................   907

Laparoscopic Distal Gastrectomy for Synchronous Gastric Cancer and Gastrointestinal Stromal Tumor
With Situs Inversus Totalis. T. NAMIKAWA, M. MAEDA, K. YOKOTA, N. TANIOKA, J. IWABU, M.
MUNEKAGE, S. UEMURA, H. MAEDA, H. KITAGAWA, Y. NAGATA, M. KOBAYASHI, K. HANAZAKI
(Kochi, Japan)...............................................................................................................................................        913

Diagnostic Utility of Oncomine Comprehensive Assay v3 in Differentiating Between Isocitrate
Dehydrogenase (IDH)-mutated Grade II-III Astrocytoma and Oligodendroglioma. S.-W. KIM, B.J.
PARK, H.-S. KIM, K. NA (Seoul, Republic of Korea).............................................................................                                       921

Prognostic Role of Lung Immune Scores for Prediction of Survival in Limited-stage Small Cell Lung Cancer.
L. SCHNÖLLER, L. KÄSMANN, J. TAUGNER, R. ABDO, C. EZE, F. MANAPOV (Munich, Germany) .....                                                                            929

Risk Factors Associated With Complications After Unilateral Immediate Breast Reconstruction: A
French Prospective Multicenter Study. J. DAUPLAT, E. THIVAT, P. ROUANET, E. DELAY, K.
CLOUGH, J.-L. VERHAEGHE, I. RAOUST, M. BANNIER, P. LEMASURIER, C. POMEL (Clermont
Ferrand; Montpellier; Lyon; Paris; Vandoeuvre-lès-Nancy; Nice; Marseille; Saint Cloud, France) .......                                                               937

KRAS Mutation in an Implant-associated Peripheral Giant Cell Granuloma of the Jaw: Implications of
Genetic Analysis of the Lesion for Treatment Concept and Surveillance. R.E. FRIEDRICH, F.
WÜSTHOFF, A.M. LUEBKE, F.K. KOHLRUSCH, I. WIELAND, M. ZENKER, M. GOSAU (Hamburg;
Magdeburg, Germany)............................................................................................................................                      947

An Institutional Audit of Maximum Heart Dose in Patients Treated With Palliative Radiotherapy for
Non-small Cell Lung Cancer. C. NIEDER, K.S. IMINGEN (Bodø; Tromsø, Norway) ...........................                                                               955

Multiple Intraosseous Lipomatosis – A Case Report and a Review of the Literature. D. DAMMERER,
J. NEUGEBAUER, D. PUTZER, B. HENNINGER (Innsbruck, Austria).................................................                                                         959

Homozygosity for rs17775810 Minor Allele Associated With Reduced Mortality of COVID-19 in the UK
Biobank Cohort. S. LEHRER, P.H. RHEINSTEIN (New York, NY; Severna Park, MD, USA).............                                                                        965
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Contents continued

Double-layered Nanofibrous Patch for Prevention of Anastomotic Leakage and Peritoneal Adhesions,
Experimental Study. J. ROSENDORF, M. KLICOVA, L. CERVENKOVA, R. PALEK, J. HORAKOVA,
A. KLAPSTOVA, P. HOSEK, V. MOULISOVA, L. BEDNAR, V. TEGL, O. BRZON, Z. TONAR, V.
TRESKA, D. LUKAS, V. LISKA (Prague; Liberec; Pilsen, Czech Republic)...........................................                                                 731

Induction of Immunogenic Cell Death of Esophageal Squamous Cell Carcinoma by 5-Fluorouracil
and Cisplatin. J. NISHIMURA, S. DEGUCHI, H. TANAKA, Y. YAMAKOSHI, M. YOSHII, T. TAMURA,
T. TOYOKAWA, S. LEE, K. MUGURUMA, M. OHIRA (Osaka, Japan)................................................                                                       743

Reduced Expression Level of GPX2 in T1 Bladder Cancer and its Role in Early-phase Invasion of
Bladder Cancer. A. MINATO, H. NOGUCHI, R. OHNISHI, I. TOMISAKI, T. NAKAYAMA, N.
FUJIMOTO (Kitakyushu; Kagoshima, Japan) ........................................................................................                                753

Drug Screening of Potential Multiple Target Inhibitors for Estrogen Receptor-α-positive Breast Cancer.
Y.-H. DAI, G.-Y. CHEN, C.-H. TANG, W.-C. HUANG, J.-C. YANG, Y.-C. WU (Taichung, Taiwan,
ROC).......................................................................................................................................................     761

Combination Cancer Therapy of a Del1 Fragment and Cisplatin Enhanced Therapeutic Efficiency In Vivo.
H. KITANO, Y. MASAOKA, A. MAMIYA, Y. FUJIWARA, T. MIKI, C. HIDAI (Tokyo, Japan)...................                                                              779

Sex-specific Changes in Brain Estrogen Metabolism Induced by Acute Trimethyltin Exposure. J.H.
LEE, S.-H. CHO, E.H. JANG, S.A. KIM (Daejeon, Republic of Korea) ................................................                                               793

Significant Association of Chitinase 3-like 1 Genotypes to Asthma Risk in Taiwan. G.-L. CHEN, S.-C.
WANG, T.-C. SHEN, W.-S. CHANG, C. LIN, T.-C. HSIA, D.-T. BAU, C.-W. TSAI (Taichung; Taipei,
Taiwan, ROC).........................................................................................................................................           799

Gene Expression Profile of Vascular Endothelial Growth Factors (VEGFs) and Platelet-derived Growth
Factors (PDGFs) in the Normal Cornea. A.R. DAN COSNITA, M. RAICA, M.P. SAVA, A.M. CIMPEAN
(Timisoara, Romania) .............................................................................................................................              805

TBX15 rs98422, DNM3 rs1011731, RAD51B rs8017304, and rs2588809 Gene Polymorphisms and
Associations With Pituitary Adenoma. G. JUKNYTĖ, I. LAURINAITYTĖ, A. VILKEVIČIŪTĖ, G.
GEDVILAITĖ, B. GLEBAUSKIENĖ, L. KRIAUČIŪNIENĖ, R. LIUTKEVIČIENĖ (Kaunas, Lithuania).........                                                                    815

Association of hsa-mir-328-3p Expression in Whole Blood With Optical Density of Retinal Pigment
Epithelial Cells. E. KUNCEVICIENE, B. BUDIENE, A. SMALINSKIENE, A. VILKEVICIUTE, R.
LIUTKEVICIENE (Kaunas, Lithuania) ....................................................................................................                          827

Pre-Treatment of Pterostilbene Enhances H2O2-induced Cell Apoptosis Through Caspase-dependent
Pathway in Human Keratinocyte Cells. Y.-C. CHENG, P.-Y. CHEN, T.-D. WAY, C.-L. CHENG, Y.-
P. HUANG, T.-C. HSIA, Y.-C. CHOU, S.-F. PENG (Taichung; Taipei, Taiwan, ROC) .......................                                                            833

Therapeutic Effects of Tonsil-derived Mesenchymal Stem Cells in an Atopic Dermatitis Mouse Model.
H. JUNG, G.M. SON, J.J. LEE, H.S. PARK (Chuncheon, Republic of Korea) .....................................                                                     845

Translational Control of Serrate Expression in Drosophila Cells. G. DELICONSTANTINOS, K.
KALODIMOU, C. DELIDAKIS (Heraklion, Greece) ...............................................................................                                     859
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