GOUT - KEEPING YOU ON YOUR TOES - HEALTH SERIES | ISSUE 06

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GOUT - KEEPING YOU ON YOUR TOES - HEALTH SERIES | ISSUE 06
GOUT – KEEPING YOU
ON YOUR TOES

How to keep gout in check, in your own stride   HEALTH SERIES | ISSUE 06

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GOUT - KEEPING YOU ON YOUR TOES - HEALTH SERIES | ISSUE 06
CONTENTS

Ancient Beginnings .......................................................................................................                 1

Detecting Gout                   .......................................................................................................   4

When Gout Attacks! .......................................................................................................                 5

Taking Action                    .......................................................................................................   6

Gout-Free Living                 .......................................................................................................   8

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GOUT - KEEPING YOU ON YOUR TOES - HEALTH SERIES | ISSUE 06
ANCIENT BEGINNINGS
Known throughout                             settle in the soft tissues surrounding     What causes gout?
                                             the joint and cause the area to redden,    A build-up of uric acid crystals
history as the ‘rich                         swell and become painful. These            occurs when uric acid, a common
man’s disease’ or                            swellings often occurs in the joints of    waste product, builds up. Uric acid
the ‘disease of                              the body, especially the big toe. Other    is produced when the body digests
                                             parts such as the ankles, knees, wrists,   purines – a substance found in many
kings’ – gout is one
                                             fingers, elbows and even instep of the     types of food and in the tissues of
of the oldest forms                          foot can also be affected.                 the body.
of arthritis.
                                                                                        Usually the kidneys can pass out
Records of ancient Egypt and Rome                                                       excess uric acid in the urine. However,
have been found to describe the                                                         if there is too much uric acid for the
disease, which was associated with                                                      kidneys to excrete effectively, the levels
indulgent lifestyles. Gout is a chronic                                                 of uric acid in the blood rises. This
– or long-term disease – but it can be                                                  condition is called hyperuricemia –
managed with medications and lifestyle                                                  a term that means “too much” (“hyper”),
changes. Early detection of gout in                                                     “uric acid” (“uricemia”). Prolonged
its early stages can also reduce the                                                    hyperuricemia may lead to gout
occurrence and severity of the painful                                                  over time.
swellings that mark the disease.
                                                                                        Other risk factors
What is gout?                                                                           Many different factors can cause gout –
Very simply, gout occurs when there is                                                  and although it is commonly associated
too much uric acid in the body, causing                                                 with a rich diet, diet is not the only
uric acid crystals to form. These crystals                                              factor. However, if you already have a

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GOUT - KEEPING YOU ON YOUR TOES - HEALTH SERIES | ISSUE 06
How Is Gout Formed

       Purine Sources                    Uric Acid                      Hyperuricemia                    Gout

       Purine is a                       During the digestive           If the kidneys cannot            When uric acid
       naturally occurring               process and bodily             eliminate uric acid in           forms into tiny
       substance found                   functions, the body            the urine, the level             needle-like crystals
       in food and the                   breaks down purines            of uric acid rises in            that collect in the
       tissues of the body.              into uric acid                 the blood                        joints, it causes pain,
                                                                                                         redness and swelling

high chance of developing the disease,                                                       of high-purine foods, such as organ
a rich diet and a sedentary lifestyle                                                        meats, dried beans, peas, anchovies
can increase the chance of getting                                                           and gravy can lead to high level of
gout. In most cases gout is most likely                                                      uric acid in the blood (hyperuricemia).
to develop due to a combination of                                                           In the long term, hyperuricemia may
factors. In some cases, gout is caused                                                       lead to gout. Typically, it takes about
by medical conditions and/or medicines.                                                      20 to 40 years of ongoing
                                                                                             hyperuricemia to develop gout, which
Genes: Gout is mostly inherited                                                              is why the condition usually develops
If your grandfather or father had                                                            in older adults.
gout, you stand a higher chance of
developing the disease as well. One                                                          More weight, more purines
study from the National Institute of                                                         If you are overweight, you have a higher
Arthritis and Musculoskeletal and Skin                                                       chance of getting gout. This is because
Diseases in the United States found that                                                     purines are not only found in food, but
18 per cent of people who suffer from                                                        also in our tissues. It is a normal bodily
gout had a family member who also              higher level of uric acid in the blood. In    process to break down tissues. This
had the disease. One of the causes of          women, the female hormone estrogen            releases the purines that break down to
gout is a genetic condition that prevents      appears to have a protective effect           uric acid. In people who are overweight,
the body from breaking down purines            that improves the removal of uric acid        there are more tissues in the body for
efficiently, leading to more uric acid in      excretion by the kidneys. However,            breakdown and thus more production
the blood.                                     after menopause, the risk of a woman          of uric acid.
                                               getting gout starts to be the same
Gender and age:                                as the risk for men. Women tend to            Medical conditions
Men above 40 are most at risk                  develop gout at a later age than men.         Some diseases and conditions can
Men aged 40 and above have a                                                                 increase the risk of gout. These include
significantly at higher risk for gout.         Diet: High-purine foods                       high blood pressure (hypertension)
This is because men tend to have a             A diet that consistently contains a lot       and diabetes, high cholesterol in the

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GOUT - KEEPING YOU ON YOUR TOES - HEALTH SERIES | ISSUE 06
blood (hyperlipidemia), the narrowing
of the arteries (arteriosclerosis),
kidney impairment or kidney failure,
an underactive thyroid gland
(hypothyroidism) and psoriaris
(a skin condition). People who have
had organ transplants are also at risk
of developing gout.

Alcohol: Excessive intake of
beer and spirits
Drinking too much alcohol can increase      than those who did not drink. Not only      the risk of gout the most. Wine drinking
the risk of gout. In a 2004 American        does alcohol break down to purines          in moderation is not linked to the risk of
study published in the medical journal,     and uric acid, it actually also increases   developing gout. In recent times, binge
Lancet, it was found that men who           the body’s production of uric acid and      drinking among young adults has been
drank two or more beers in a day had a      reduces the body’s ability to remove        linked to the earlier development of
2.5 times higher chance to develop gout     uric acid. Beer in particular increases     gout, particularly among women.

                      Are You At Risk Of Gout?                    What To Do If You Are At Risk

      •    Male over 40 years old                                 •    Talk to your doctor about your concerns and take a
      •    Overweight                                                  blood test if needed
      •    Have a family history                                  •    Cut down on rich food, especially high-purine foods
      •    Eat a diet high in seafood, organ meats,                    like meat, organ meat and seafood
           anchovies or gravy                                     •    Cut down on excessive alcohol intake
      •    Drink alcohol in large amounts                         •    Increase your water intake

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GOUT - KEEPING YOU ON YOUR TOES - HEALTH SERIES | ISSUE 06
DETECTING GOUT
                       Some ways to detect if                        Joint fluid test
                       you have gout                                 A more accurate way to detect if you
                       Blood test                                    have gout is to check if you have uric
                       A blood test may be used to check the         acid crystals in your joints. The test
                       level of uric acid level in your blood.       is called a joint aspiration. A needle
                       This is not always accurate – some            is used to draw some fluid from your
                       people have high uric acid levels, but        affected joint and examined under
                       never develop gout, while some people         the microscope. If there are uric acid
                       get gout, but do not show unusually           crystals in the fluid, a diagnosis of gout
If you suspect you     high levels of uric acid in their blood.      is confirmed.
are at risk of gout
or have suffered
                                          What To Do If You Have Gout
an attack, it’s best
to seek medical
                           •    Follow your doctor’s advice
advice from your                on medicine prescriptions
general practitioner            and follow-up appointments,
(GP) who can help               including blood tests
                           •    Reduce the amount of high
in diagnosing the               purine foods in your diet
condition and                   (refer to page 2)
recommending the           •    Drink plenty of non-alcoholic
                                fluid, especially plain water,
best way to tackle
                                to flush uric acid from the body
the disease.               •    Avoid alcohol, particularly beer and liquor as they increase uric
                                acid production
                           •    Avoid sugary and carbonated drinks – these are linked to an increased
                                risk of gout attacks
                           •    If you are overweight, attempt to lose some inches. Even if you are
                                not, be sure to exercise regularly. Avoid ‘quick fixes’ – such low-
                                carbohydrate diets -- as these can end up increasing the level of uric
                                acid in your blood

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GOUT - KEEPING YOU ON YOUR TOES - HEALTH SERIES | ISSUE 06
WHEN GOUT ATTACKS!
                                             Gout can also cause                              Kidney stones: All that excess uric
                                             other complications                              acid crystal may also collect in the
                                             Tophi: Untreated gout may cause uric             urinary tract, causing kidney stones.
                                             acid crystals to not only be deposited
                                             in the joints but also under the skin to         Deformity: The affected parts can
                                             form lumps called tophi (pronounced              become so swollen that it causes
                                             ‘toe-fi’). These lumps are not painful,          permanent deformity. If it affects the
                                             but can become sore and swollen                  feet and hands, the condition can also
                                             during a gout attack.                            limit actions walking and typing.
A gout flare-up can
happen suddenly –
and usually at night.                                                        The Stages Of Gout
                                                                       Gout progresses in four main stages
An episode of gout
is aptly called an
‘attack’ – because                                                Stage 1: Asymptomatic Hyperuricemia
                                                                  Asymptomatic means ‘without symptoms’. In this early stage,
the pain is described                                             the uric acid level in the blood is high, but does not cause any
                                                                  symptoms. In most cases, treatment is not needed.
as being so intense
that even the lightest                                               Stage 2: Acute Gout (also known as Acute Gouty Arthritis)
                                                                     Acute means ‘sudden’. In this second stage, the uric acid
touch is unbearable.                                                 crystals collect in the joints and cause a sudden onset
                                                                     of severe pain and swelling. An episode of gout usually
                                                                     subsides within 3 to 10 days, even without treatment. The
Some people say it is as if the skin                                 next attack may not occur for some time, but if not managed
                                                                     with medication or lifestyle changes, attacks can last longer
is “on fire”. An attack can last from                                and happen more frequently.
between 3 and 1 days. In between
attacks, there is usually no pain                                    Stage 3: Interval Gout
and one can go about daily life with                                 This is the period between (hence ‘interval’) acute attacks.
                                                                     In this stage, a person does not have any symptoms.
no hindrance.

Signs and symptoms you need to                                    Stage 4: Chronic Gout
look out for                                                      This is the most disabling stage of gout. It usually develops
                                                                  over a long period, such as 10 years. In this stage, the
•   Sudden development of a swollen,                              disease may have caused permanent damage to the affected
    red, and warm joint                                           joints so they are deformed and so make it difficult to walk,
                                                                  use your hands or arms.
•   Swelling, redness and pain that
    affects only one joint, often the toe,
    ankle, or knee

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GOUT - KEEPING YOU ON YOUR TOES - HEALTH SERIES | ISSUE 06
TAKING ACTION
                                                                       pain and look for solutions.
                                                                       •   Take your medications
                                                                           as prescribed
                                                                       •   Try applying ice to the affected
                                                                           joint and raise it slightly
                                                                       •   Increase your intake of water. Be
                                                                           sure to drink more fluids (about
                                                                           2 to 4 litres a day and ensure at
                                                                           least half your fluid intake should
                                                                           be water)
                                                                       •   Be sure to rest during a gout
                                                                           attack and let the episode pass.
                                                                           Distract yourself with activities
                                                                           such as reading, deep breathing
                                                                           and other light hobbies.

                                                                       Know your gout medicines
                                                                       The type of medication for gout
                                                                       depends on the stage of disease, so
What happens           Managing gout and                               management is often tailored for your
                       preventing attacks                              specific needs and severity of the
after a diagnosis of   The goals of disease management                 disease. The common medications
gout is confirmed?     are to:                                         used in gout management seek to:
The good news is       1.   Relieve the pain and swelling              •   Reduce the discomfort of a gout
                            during a gout attack
that the symptoms                                                          attack by relieving the pain and
                       2.   Prevent future gout attacks                    swelling
of gout can be         3.   Prevent or reduce tophi and reduce         •   Prevent future attacks by reducing
controlled and              the risk of kidney stones                      the level of uric acid in the blood
reduced with           4.   Lower risk of long-term damage to          The specific brands of medications
                            the affected joints                        and the most effective dose will be
medications and
                                                                       determined by your doctor. Here are a
change in diet.        What to do in a gout attack!                    list of common types of medicines used
                       If gout still strikes, it’s important to have   in gout management.
                       a plan so you will take your mind off the

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GOUT - KEEPING YOU ON YOUR TOES - HEALTH SERIES | ISSUE 06
Non-steroidal anti-inflammatory              used you who cannot take NSAIDs               Medications to reduce uric
drugs (NSAIDs)                               or colchicine.                                acid production
Drug action: NSAIDs are a group of                                                         Apart from medications to reduce and
drugs that reduce inflammation but are       Side effects and risks: Corticosteroids       prevent gout attacks, your doctor may
not steroids. NSAIDs work by lowering        lower the immune system and                   also prescribe medications to prevent
the body’s production of chemicals that      decreases the body’s ability to fight         and reduce your risk of gout-related
cause inflammation, pain, and fever          infection, long term intake of the drug       complications. These include drugs that
(known as prostaglandins).                   also leads to weakened bones and              block uric acid production, or help the
                                             poor wound healing. Because of their          body expel uric acid. These medicines
Side effects and risks: Be aware             serious side effects, your doctor will find   also can help reduce the size of tophi
that NSAIDs can cause stomach                the lowest dose for you that effectively      and kidney stones.
irritation. In rare cases, they can also     controls your symptoms and prescribe
affect the kidneys. Though NSAIDS are        them for the shortest time possible.          Take your medicines!
effective pain medicines, the longer you                                                   Speak with your doctor about your
take them, the more likely side effects      Colchicine                                    concerns about medications and side
can occur. These include vomiting,           Drug action: Colchicine is a type of pain     effects, but be sure to comply with his
nausea, constipation, diarrhea, poor         reliever that, if taken soon after gout       or her advice. Taking your medications
appetite, headache, dizziness, rashes        symptoms appear, will reduce the pain         regularly in the prescribed dose and
and drowsiness.                              in a short time. Colchicine is given if       frequency is the best way to control
                                             NSAIDs or corticosteroids fail to control     gout and prevent painful flare-ups.
Corticosteroids                              symptoms. To prevent future attacks
Drug action: Corticosteroids are strong      your doctor may also prescribe a low
anti-inflammatory hormones that act          daily dose of colchicine.
quickly to reduce pain. They can be                                                        TIP
taken in pill form or injected directly      Side effects and risks: Colchicine can        Use a pill box or download a medication
into an affected joint to relieve the pain   cause abdominal cramps, nausea,               reminder app to help you remember to
and swelling. Corticosteroids are usually    vomiting and diarrhoea.                       take your medicines on time!

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GOUT - KEEPING YOU ON YOUR TOES - HEALTH SERIES | ISSUE 06
GOUT-FREE LIVING
                          Your doctor will work out an effective    you make those positive steps to
                          disease management plan for you that      feeling better physically and mentally.
                          may include: medications, blood tests
                          and follow-up consultations. You may      A healthy eating plan for gout
                          also be advised to make some lifestyle    A diet low in purines is the best way to
                          and diet changes that are useful in       prevent gout attacks. Avoiding purines
                          preventing gout from getting worse.       completely is impossible, but you can
                          It is important to be proactive about     strive to limit them. Some foods can
                          your condition – these steps can help     trigger gout in others but not in you.

                                           EMPOWER YOURSELF

                              Understand your condition: Read up on it; talk to your doctor;
                              ask for advice. The more you know, the more prepared you are to
                              handle the disease
If you or a family
member have been              Make a change: Gout is partly caused by lifestyle factors, so
diagnosed with                if you recognise any of the risk factors in your own life, make
                              a stand to change them. If you smoke, stop. Eliminate alcohol
gout, it can be a             intake. Reduce the amount of caffeine you drink. If you are on the
worrying time. Fear           heavy side, lose weight. Start exercising!
not, the good news
                              Clean out your diet: One of the main causes of high uric acid in
is that gout can be
                              the blood is the excessive intake of foods high in purine. While it’s
controlled effectively.       not possible to avoid purine entirely (your cells contain it after all!),
                              lowering your intake of high-purine food is a good way to lower
                              the risk of a gout attack.

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Learn to identify your body’s own             you may add more foods from            Lowering your uric acid level through
tolerance level and which foods are           this ‘moderate’ category.              diet can help you to manage gout
more problematic.                                                                    more effectively, said Dr Tan York
•   STEP 1: Eliminate foods in the       What someone else with gout finds           Kiat, Consultant, Rheumatology and
    ‘high-purine’ category               safe to eat, may or may not be safe         Immunology Department, Singapore
•   STEP 2: Reducing the intake of       for you. By consulting a doctor and         General Hospital (SGH), in an article for
    foods in the ‘moderate-purine’       careful choice of low- and moderate-        Health Xchange .
    category. If you can eat from this   purine foods, you can determine a
    group and don’t have gout attacks,   ‘safe’ level of purines in your diet.

    High-Purine Foods                     Moderate Purine Foods                  Gout-Friendly Foods
    Eliminate these foods                 Eat in moderation                      Eat in moderation
    Eat only very occasionally            About 2-3 times a week                 Safe for gout

    •   Anchovies                         •    Beef                              •    White bread, pasta, noodles, rice
    •   Asparagus                         •    Chicken                           •    Nuts: walnuts, almonds,
    •   Organ meats: beef kidneys,        •    Duck                                   flaxseed, cashews
        brains, liver, sweetbreads        •    Pork and ham                      •    Eggs (limit to 3 times a week)
    •   Dried beans and peas              •    Seafood: crab, lobster,           •    Low-fat dairy products
    •   Game meats                             oysters, prawns, scallops         •    Coldwater fish: tuna, salmon,
    •   Gravy                             •    Wholegrain bread                       cod (limit to one serving a day)
    •   Mackerel                          •    Wholegrain pasta                  •    Kailan, cabbage, squash,
    •   Mushrooms                                                                     beetroot, red peppers,
    •   Sardines                                                                      corn, potatoes, celery,
    •   Bacon                                                                         tomato, eggplant,
    •   Meat extracts                                                            •    Oranges, apples, pears,
                                                                                      pineapple, papaya, tangerine,
                                                                                      berries, bananas, peach, cherries
                                                                                 •    Avocado
                                                                                 •    Coffee and tea
                                                                                 •    Chocolate, ice-cream
                                                                                      (in moderation)

                                                                                                                                 9
HEALTHY RECIPES FOR YOU

Breakfast ideas                     Meals on the go                   Something piping hot

•   Cornflakes, low-fat milk or     •   Shredded chicken breast,      •   Roast chicken marinated
    cereal and some strawberries,       cubed apple, chopped              with rosemary and garlic
    berries or a banana                 walnuts and sliced                with potatoes
•   Toast with almond butter and        celery tossed with a little   •   Fish soup with tofu,
    banana slices                       light mayonnaise                  bittergourd and steamed
•   Vegetable omelette with         •   Pasta with avocado, roasted       white rice
    tomatoes, red peppers               eggplant and red peppers      •   Pasta with spicy tomato
    and onion                           strips, corn kernels and a        sauce and grilled vegetables
•   Smoothie made with                  sliced hardboiled egg         •   Stir fried kailan and taukwa
    plain low-fat yoghurt, fruit    •   Sandwich wrap with cream          with beef slices served with
    and flaxseed                        cheese, smoked salmon and         steamed white rice
                                        salad leaves

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Alternative remedies for gout              lowering uric acid. Some dark cherry
                                     Some types of foods may help reduce        juice, and a serving or two of fresh
                                     the symptoms of gout by lowering uric      cherries and other dark-coloured fruits,
                                     acid. Though more research is needed,      including blueberries, blackberries,
                                     try adding moderate amounts of these       raspberries and purple grapes may be
                                     into your diet:                            a good way to get your vitamins and
                                                                                lower uric acid production as well.
                                     Vitamin C: Though vitamin C has not
                                     been accepted as a ‘treatment’ for         Deep breathing: Try natural pain
                                     gout, it may reduce the levels of uric     management while waiting for your
                                     acid in the blood . Be aware that large    medications to kick in. Deep breathing
                                     doses of vitamin C may increase and        not only fills the body with energising
                                     not decrease uric acid levels, however.    oxygen, it also triggers the relaxation
                                     The best way to get your vitamin C is to   response and may help take your mind
                                     include more fresh fruits and vegetables   off the pain. Try other mindful exercises
                                     in your diet.                              like meditation, tai chi and yoga when
                                                                                your gout is not active as these may
                                     Cherries: The dark-coloured                help with pain relief, reduce stress and
                                     compounds that give cherries their         build emotional health.
                                     attractive colour may have the effect of

Top apps for managing gout

Gout Channel                         Gouty Uric Acid Database
(Free; Android and iOS)              (Free; Android)
Learn more about the causes and      Can’t remember which foods are high in
symptoms of gout and how to manage   purines? Use this app as a reference to
the problem with a proper diet and   find out whether your lunch or dinner is
lifestyle changes.                   in the safe zone.

                                                                                                                            11
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SOURCES:

http://www.mayoclinic.com/health/gout/DS00090; http://www.arthritistoday.org/
tools-and-resources/expert-q-and-a/gout-questions/food-for-gout.php; http://
health.nytimes.com/health/guides/disease/gout-chronic/causes-and-risk-factors.
html; http://www.healthxchange.com.sg/healthyliving/SpecialFocus/Pages/
Gout-Rich-Man-Disease-No-More.aspx; http://www.healthxchange.com.sg/
healthyliving/DietandNutrition/Pages/Diet-for-Gout-What-Foods-Can-You-Eat-to-
Keep-Your-Uric-Acid-in-Check.aspx; http://www.acumedico.com/purine.htm
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