Functional ingredients for dietary supplement industry - SUDATHIP SAE-TAN, Ph.D. Department of Food Science and Technology Faculty of ...
←
→
Page content transcription
If your browser does not render page correctly, please read the page content below
Functional ingredients for dietary supplement industry SUDATHIP SAE-TAN, Ph.D. Department of Food Science and Technology Faculty of Agro-Industry Kasetsart University March, 2021 1
Nutraceuticals Nutrition + Pharmaceutical "A nutraceutical is a food or part of a food such as a dietary supplement that has a medical or health benefit including the prevention and treatment of disease". 3
2022 2015 $170 Billion $302 Billion Allied Market Research, 2020 100% 90% 80% 70% 60% Row 50% North & South America 40% Europe 30% Asia 20% 10% 0% 2007 2015 2020 Frost & Sullivan, 2016 4
CONSUMER TRENDS IN SUPPLEMENTS Mental health & Healthy aging Gut health and wellness well-being 55 Immune health Sports & Beauty Performance
Ingredients to watch for healthy ageing Antioxidant Claim for a wide range of healthy ageing benefits 1 ASTAXANTHIN 2 MAQUI BERRIES 3 GRAPE SEED EXTRACT 7
Ingredients to watch for healthy ageing Astaxanthin Claim: High in antioxidants Source for industry: algae Haematococcus pluvialis (H. pluvialis) (bacteria, microalgae, yeasts) H. pluvialis is a green microalga that grows in fresh and brackish (slightly salty) waters. Under certain 'stressful' conditions, such as high light intensity or nutrient shortage, the cells of H. pluvialis accumulate astaxanthin, which turns them a dark-red colour. Synthetic or 'manufactured' forms of astaxanthin are also available (EFSA). 8
Maqui berries • Antioxidant • Cardiovascular disorder • Obesity • Analgesic activity 11 Agronomy. 2019
Maqui berries • Anti-diabetes • Anti-inflammation Eye health • Dry eye disease Suppress light-induced photoreceptor cell death by inhibiting ROS production 12 Phytochemistry Reviews. 2017
Maqui berries 13
Maqui berries 14
Ingredients to watch for healthy aging Grape seed extract Bioactive compounds Monomeric & Oligomeric flavan-3-ols 15
Grape seed extract Antioxidant • Cardiovascular disorder Anti-ulcer activity Anti-cancer 16 Nutr J. 2017
Grape seed extract Chemoprevention of cellular damage 17 Current Pharmarceutical Biotechnolgoy, 2001.
Grape seed extract 18
Grape seed extract #1 Beauty and Personal Care - Facial treatment, shampoo, conditioner, hand cream, sunscreen, moisturizer, serum 19
Grape seed extract Food and drink (9%) - Meal replacement drinks, Pre-workout drinks, Drinks, Gummy Coconut Water + Chocolate Kola Nut Flavoured Post Workout Cardio Plant Vegan Pre-Workout Pomegranate New Zealand Super Based Powder Powder Tea blend of white tea, grape seed extract and natural pomegranate flavour 20
CONSUMER TRENDS IN SUPPLEMENTS Mental health & Healthy aging Gut health and wellness well-being 21 21
Products that support mental health and well-being A rise of mental health awareness and well-being - Consumers seek for holistic solutions. - Long-term physical, mental and emotional health - Stress becomes a key health concern. - Greater awareness for environmental impacts 22 22
Products that support mental health and well-being Beauty and Personal care products Improve or Internal & change external well- appearance being 23 23
Products that support mental health and well-being 24 24
Mental health and well-being Links between mental states and performance Solutions that support people with focus, attention and even mood elevation 1 ADAPTOGENS 2 NOOTROPICS 25 25
Ingredients to watch for mental health and well-being Adaptogens Any ingredient that can help the body to better cope with physical or mental stress Originally defined as “non-specific resistance under stress” control over their stress 26 26
Adaptogens 27 27
Adaptogens Ashwagandha Holy basil Medicinal mushrooms Cope with stress Help to relax Nervines 28 28 Chamomile Lemon balm Valerian Lavender
Adaptogens Medicinal mushrooms • Ganoderma lucidum (Reishi) • Lentinus edodes (Shiitake) • Inonotus obliquus (Chaga) • Cordyceps sinensis (Cordyceps) 29 29
Adaptogens Ganoderma lucidum (Reishi) 1. Polysaccharides 2. Triterpenes 30 30
Adaptogens Ganoderma lucidum (Reishi): Polysaccharides 1. Neurological effects - Anti-depressant like effect - Reduce anxiety-type behaviour 2. Immune-modulation 31 31 Phytochemistry. 2015
Adaptogens Ganoderma lucidum (Reishi): Triterpenes 1. Antioxidant - Increase antioxidant enzymes activity (SOD and catalase) (remove ROS) - Reduce radiation-induced oxidative DNA damage 2. Anti-cancer and cytotoxic activities 3. Anti-metastatic activities 4. Anti-HIV activity 5. Lowering urinary tract symptoms in men 6. Neuro-protective effect 32 32 Phytochemistry. 2015
Adaptogens Lentinus edodes (Shiitake) • Amino acids • Neutral sugar • Total phenolics • Organic acids • β-glucan • Tasty compounds 33 33 Journal of food measurement and characterization. 2012
Adaptogens Lentinus edodes (Shiitake) 1. Lower blood pressure & plasma lipids 2. Anti-gestational diabetes 3. Immune booster J. Nutr. Sci. Vitaminol. 1987 International Journal of Medicinal Mushroom, 2017 34 34 Ann Transl Med. 2014, J Immunol Res., 2019
Adaptogens Immune Booster Lentinus edodes Grifola frondosa (Shiitake) (Maitake) 35 35 J Am Coll Nutr., 2015
Adaptogens Inonotus obliquus (Chaga) Bioactive compounds: - Hispidin analog - Melanins 36 36 Mycosystema. 2008
Adaptogens Inonotus obliquus (Chaga) 1. Immune stimulator 2. Anti-inflammation 3. Hypoglycemic and antioxidant activity 4. Anti-tumor activity Mycosystema. 2008 Journal of Ethnopharmacology. 2009 Journal of Food Biochemistry, 2010 37 37 International Journal of Medicinal Mushrooms, 2011
Adaptogens Cordyceps sinensis (CS) Active ingredients • Polysaccharides • Nucleotides • Sterols • Proteins 38 38 Journal of functional foods, 2013
Adaptogens Cordyceps sinensis (CS) 1. Adaptogenic activity 2. Immunomodulatory effects 3. Antioxidant activity 4. Anti-cancer 5. Anti-diabetes activity 6. Anti-inflammatory activity 7. Kidney protection (Lower increment of blood uria nitrogen, sodium secretion) 8. Lung and liver protection (Enhance oxygen utilization, Enhance cellular oxygen uptake) 9. Apoptosis 10. Anti-fatigue and improve stamina 39 39 Journal of functional foods, 2013
Adaptogens Over the last five years, 35% of food, drink, or healthcare launches with adaptogen or adaptogenic in the product description. Rise of medicinal Nervines: Hemp extract and Tulsi Breakfast Tea mushroom for stress lavender,chamomile, ginseng : (India) uses holy basil to and fatigue lemon balm etc. : Hemp extracts and relieve stress Spices and adaptogens adaptogens 40
Adaptogens “Beauty-sleep” combo Probiotic drink for stress & sleep Drinking your way to sleep & Jelly Carrageenan and Konjac with Contains kefir culture, probiotics, relax Chamomile, Lemon Balm, Lavender, lemon and lavender that are said contains hops and lemon balm L-Theanine and 10% White Grape to relieve stress, improve mood, to help relieve feelings of Juice helps relieve hunger and is promote restful sleep, reduce stress and to encourage concentrated with chamomile, inflammation and lower skin peaceful sleep (Philippines). lemon balm and l-theanine for irritation (Malaysia). sleep (Thailand). 41
Ingredients to watch for mental health and well-being Nootropics ‘Brain boosters' or ‘Smart drugs’ 42
Nootropics Caffeine is considered the most common nootropic. Other emerging nootropics are B vitamins, choline, L-theanine, MCT oils, omega-3s and ginko biloba THAILAND 30% of Thai consumers use functional foods and drink to support and maintain healthy brain function 43
Nootropics Mintel's Augmented Human Trend, Discusses how recent innovations are enhancing the way we live – offering opportunities to push the body beyond its limits. 44
Nootropics Contains a unique herbal blend Contains L-theanine The caffeinated beverage is of amla, gotu kola, ginkgo Suntheanine, NZ Neuroberry made with natural functional biloba, siberian ginseng, green Juice and NZ Pine Bark Extract ingredients like gingko biloba, tea and B vitamins and zinc to Enzogenol for mental focus turmeric, siberian ginseng, boost focus (Australia). and clarity (New Zealand). green tea, caffeine, vitamin B6 and vitamin B12 for mind and health benefits (Australia). 45
Nootropics Contains a comprehensive Contains caffeine (95mg), B Contains L-tyrosine, vitamins C, formula blend of dark vitamins, choline, green tea E, B12 and B6 and electrolytes chocolates and natural and ground ginger that help to such as sodium, magnesium nootropics including lion's deliver alertness and focus and potassium for focus, mane mushroom, green tea without the drawbacks of the hydration and recovery (US). extract, ginkgo biloba, sugar commonly found in natural caffeine and B energy drinks (US). vitamins to increase mental energy. 46
CONSUMER TRENDS IN SUPPLEMENTS Mental health & Healthy aging Gut health and wellness well-being 47 47
Ingredients to watch for gut health and wellness Virtual organ of the body Human genome Microbiome 23,000 genes 3 million genes 48 BMJ, 2018
Ingredients to watch for gut health and wellness What does gut microbiome do? Non-digestive substrate SCFAs Gases (acetate, propionate, butyrate) 49 BMJ, 2018
Ingredients to watch for gut health and wellness 1 PREBIOTICS 2 PROBIOTICS 3 SYNBIOTICS 50
Ingredients to watch for gut health and wellness Prebiotics Fermentable Fiber fiber Microbiota-accessible carbohydrates (MACs) 51 BMJ, 2018
Ingredients to watch for gut health and wellness Prebiotics 1. Fructans Inulin, FOS 2. Galacto-oligosaccharides 3. Starch & glucose-derived oligosaccharides 4. Other oligosaccharides Pectin (Pectic oligosaccharide) 5. Non-carbohydrate oligosaccharides cocoa-derived flavonols 6. Resistance starch 52 Foods, 2019
Ingredients to watch for gut health and wellness Global: top 10 fibres used in new high/added fibre food and drink products, June 2016 and May 2020 Jun 2016 - May 2017 Jun 2017 - May 2018 Jun 2018 - May 2019 Jun 2019 - May 2020 8% 6% % launches 4% 2% 0% 53
Ingredients to watch for gut health and wellness Prebiotics High-fibre, FODMAP cereal Essential fibre FODMAP Guar gum promotes digestive Food for Health breakfast clusters crispbreads balance are FODMAP-certified and are Orgran Essential Fibre Purasana Sport Smoothie powder generally well tolerated by IBS Crispibread. This certified provides all the nutrients needed sufferers. Packed with the FODMAP-friendly product is a for a sporty lifestyle. It contains the goodness of chia seeds, linseeds good source of fibre. With brown FODMAP-approved fibre Sunfiber, and psyllium, fibres which are rice flour, sorghum flour and made from partially hydrolysed well tolerated by people with IBS psyllium seed husk to support guar gum to promotes healthy (Australia). healthy digestion (South Africa). digestive balance (Belgium). 54
Ingredients to watch for gut health and wellness Prebiotics Poorly absorbed SCFAs, sugar polyols 55 The British Journal of Nutrition, 2016
Ingredients to watch for gut health and wellness Probiotics A live microbial feed supplement, which beneficially affects the host by improving its intestinal microbial balance - Immune modulation - Anti-cancer, Anti-tumor - Reduction of cholesterol - Alleviation of lactose intolerance - Normalization of stool transit - Hepatic encephalopathy - Treatment of peptic ulcers 56 Beneficial Microbes, 2010
Ingredients to watch for gut health and wellness Prebiotics vs Probiotics Prebiotics are gaining traction in Asia Pacific and following the footsteps of 57 probiotics in food, drink and healthcare launches globally.
Ingredients to watch for gut health and wellness Synbiotics Synergistic mixture of probiotics and prebiotics that benefit the host by improving the survival and colonization of live beneficial microorganisms. Known synbiotic formulations are Bifidobacteria with fructooligosaccharides (FOS) and Lactobacillus rhamnosus GG with inulin. 58 Int J Mol Sci. 2019
Ingredients to watch for gut health and wellness Synbiotics 59
Ingredients to watch for gut health and wellness Postbiotics A new term for “metabolic by-products” or "beneficial waste products" of probiotic bacteria 60 Current opinion in food science. 2020
Ingredients to watch for gut health and wellness Postbiotics • Organic acids or SCFAs • Peptidoglycans • Polysaccharides. • Peptides • Teichoic acis • Cell surface protein vitamins • Plasmalogens 61 Current opinion in food science. 2020
Ingredients to watch for gut health and wellness Postbiotics Postbiotics derived from Bifidobacterium breve C50 - Trigger the host immune system - Trigger anti-inflammatory responses 62 Current opinion in food science. 2020
Ingredients to watch for gut health and wellness Psychobiotics Psychobiotics, probiotics that affect the brain, may have potential to help people struggling with anxiety and depression. 63 Psychopharmacology
Ingredients to watch for gut health and wellness Psychobiotics - Anxiety - Depression - Nociceptive - Stress - Feeding - Taste preference 64 J Clin Invest, 2015
Mungbean @ KU Anti-inflammation - RAW246.7 cells - Acute liver injury mice - 3T3-L1 Anti-diabetes - Inhibit α-amylase - Inhibit α-glucosidase - Inhibit AGEs formation - Increase insulin signaling 65
Mungbean LPS TLR CD14 P TAK1 COX2 IKKα iNOS IKKβ Cytoplasm P IκB Nucleus NF-κB NF-κB NF-κB binding site 66
Mungbean @ KU Anti-diabetes - Inhibit α-amylase - Inhibit α-glucosidase - Inhibit AGEs formation - Increase insulin signaling 67
Mungbean @ KU 2020 2021 2022 - Extraction - Drying - Subchronic toxicity improve bioavailability pilot scale Novel - Efficacy in animal models Food - Acute toxicity 2023 – Clinical studies Health Claim 68
Interested focuses Well-being - Healthy aging - Mental health - Gut health 69 69
Interested focuses Europe: Organic & Natural APAC: Natural & Blend of traditional North America: Natural 70 70
THANK YOU Sudathip Sae-tan, Ph.D. Phone: +662 562 5037 Email: fagists@ku.ac.th sudathip.sa@ku.th 71
You can also read