FLU VACCINE AND ME/CFS - INFORMATION FOR 2020 2021 - ME Association
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October 2020 FLU VACCINE AND ME/CFS INFORMATION FOR 2020 – 2021 ME CONNECT HELPLINE: 0344 576 5326 by Dr Charles Shepherd Hon Medical Adviser to the MEA COVID-19 AND FLU VACCINATION THIS YEAR One very important additional issue this year is the impact of COVID-19 and the Department of Health’s decision to encourage far more people to have this protection - as a dose of flu plus COVID-19 is going to be a very nasty combination of infections to have. So people with ME/CFS are going to have to take COVID-19 into consideration when deciding whether they are going to have a flu vaccination - as COVID-19 isn’t going to go away and there won’t be a vaccine available for widespread public use until the worst of any 2020-2021 flu epidemic is over.” INTRODUCTION WHAT IS THE SCIENCE Seasonal flu (also known as BEHIND FLU VIRUSES influenza) is a highly infectious AND FLU VACCINES? Flu Vaccine and ME/CFS - illness caused by several types Information for 2020 - 2021 was of flu virus. It causes up to 30,000 There are three types of influenza written by Dr Charles Shepherd deaths per year in England alone. virus. Type A viruses are the most (pictured above), Trustee and The flu virus spreads rapidly dangerous and cause outbreaks Hon Medical Adviser to The ME through small infected droplets in most years. Type B viruses Association. that are coughed or sneezed into tend to cause less severe disease the air by an infected person. © The ME Association, 2020 and smaller outbreaks, often in Even people with mild or no All rights reserved. children. Type C viruses cause a symptoms can infect other people. minor respiratory illness. Reproduction, in full or in part, So the spread of infection is just is not allowed without the the same as with COVID-19. Type A viruses are sub-divided written permission of The ME by the type of immune system As there is no simple answer as Association. markers known as antigens that to whether you should have flu are found on the surface of vaccine if you have ME/CFS, the virus. These are known as viral sub-types. So the changes the purpose of this leaflet is to haemagglutinin (H) antigens and are constantly monitored by the provide information on all aspects neuraminidase (N) antigens. These World Health Organisation in of flu vaccination in relation markers help the virus to invade order to try and make sure that to ME/CFS. You and your doctor the body cells. 18 types of H each year’s flu vaccine is going can then decide if you ought to antigen and 11 types of N antigen have this protection. to be effective against new and have been identified so far. emerging strains of flu virus. The surface antigens constantly Studies have shown that flu change their identity by what vaccine reduces the risk of is called antigenic drift (which catching flu. However, protection involves minor changes from will not be complete and will vary season to season) and antigenic from person to person. Protection shift (where a major change and gradually decreases over time new subtype of virus emerges). and flu strains change over time. Previous exposure to flu or flu So new vaccines have to be vaccination will not provide made each year and people at protection against these new increased risk are encouraged to The ME Association n 7 Apollo Office Court, Radclive Road, Gawcott, Bucks MK18 4DF n 01280 818 963 l www.meassociation.org.uk n admin@meassociation.org.uk n Registered Charity Number 801279 © ME Association 2020. Reproduction is not allowed without the written permission of The ME Association 1
FLU VACCINE AND ME/CFS: INFORMATION FOR 2020 – 2021 October 2020 be vaccinated every year. There is according to age and due to also research evidence to indicate the decreased effectiveness in that flu vaccine can reduce the people over 65, their vaccine risk of having a stroke. also contains what is called an adjuvant. Swine flu is the popular name for influenza caused by a relatively This is a substance that is added to new strain of influenza virus A. a vaccine to increase the body’s It was responsible for the flu immune response to the vaccine. pandemic in 2009-10. The virus is n Children aged 2 to 17 are officially known as influenza virus offered a live attenuated A/H1N1pdm09. quadrivalent vaccine (LAIV). This THE 2020 -2021 FLU gives protection against four strains of flu. The vaccine is given VACCINES as a nasal spray. For 2020-2021 there are three n Adults aged 18 to 64 are offered n Adults aged 65 and over will be types of flu vaccine available. a quadrivalent injected vaccine – offered an adjuvanted trivalent You will be offered the one that the vaccine will have been grown injected vaccine grown in eggs is considered to be the most either in eggs or cells (QIVe or (aTIV). effective for your age group. QIVc), which are considered to be The protection provided varies equally suitable. WHO SHOULD HAVE A FLU JAB? CAN SOMEONE WITH ME/CFS HAVE A FREE Flu vaccine is offered free on the FLU JAB IF THEY CHOOSE TO DO SO? NHS to people in certain at-risk groups. These are mainly people Having a chronic neurological disease is one of the who have a medical condition recommendations for having an NHS flu vaccination. ME/CFS is that places them at greater risk of classified by the World Health Organisation as a neurological disease. developing serious complications if This classification is fully recognised by the Department of Health. they catch flu. So The ME Association believes that people with ME/CFS should therefore qualify for a free NHS flu jab if they decide to have one. The list includes a number of pre-existing health conditions – If your GP is querying whether someone with ME/CFS is eligible to neurological and immunological have a free flu vaccination on the NHS you need to point out that the diseases, heart and respiratory answer is YES they can because: diseases, pregnant women, and n People with a chronic neurological disease are eligible for an NHS obesity. flu jab (NHS Green Book - Chapter 19, page 14) - https://tinyurl.com/ As a result of the COVID-19 yf2spxpm pandemic, the Department This publication is produced by Public Health England and provides of Health has widened the detailed guidance on the administration of all vaccines. The list of list of people who should be medical conditions where flu vaccine is recommended makes it clear encouraged to have flu vaccine. that the list of neurological conditions (and other conditions) is not So this now includes health and exhaustive and that decisions on individual neurological diseases can social care workers, people in be made on clinical judgment. residential care homes, household contacts of people who are n NHS England classifies ME as a neurological condition: https:// shielding, and people aged 50 to tinyurl.com/y6h33er2 64 - subject to vaccine availability. n Dame Sally Davies, former Chief Medical Officer at the Department People who receive a Carer’s of Health, stated in 2014: Allowance, or are the main carer “As you know, the risk of serious illness from flu and consequent for a sick or disabled person, hospitalisation and death is higher among those with underlying are also eligible for a free NHS health conditions such as M.E.” vaccine. “We know that people with chronic neurological conditions are The best time to have a flu jab is in approximately 40 times more likely to die if they develop flu than the autumn – from mid-September individuals who have no other underlying health conditions.” onwards through until early November. It takes two “The best way for people at risk from flu to protect themselves and to three weeks for the their families is to get the flu vaccine. People with clinical risk factors vaccine to become are eligible to receive the seasonal flu vaccine free each winter.” fully effective. 2 © ME Association 2020. Reproduction is not allowed without the written permission of The ME Association
FLU VACCINE AND ME/CFS: INFORMATION FOR 2020 – 2021 October 2020 in the British Medical Journal. Both WHAT ARE THE developed moderate to severe POINTS IN FAVOUR OF symptoms and were unable to return to work. HAVING A FLU JAB IF Reference: Should influenza be YOU HAVE ME/CFS? mandatory for health- care workers? British Medical Journal n Flu vaccination should provide (2013), 347:f6705. Online here: a fairly high degree of protection https://tinyurl.com/y2rf3g7 An MEA website online poll carried against the strains that are likely to be around this winter. out in November 2008 asked how WHAT ARE the flu jab affected ME symptoms. n Overall, the vaccine produces a different degree of protection THE POSSIBLE There were 191 responses. 86 (45%) reported no change; 52 (27%) said each year – usually around 40% - DISADVANTAGES? they were much worse; 42 (22%) 50% said they were slightly worse; 7 There are anecdotal reports n Protection continues for about of people with ME/CFS (4%) said they were slightly better a year. suffering a relapse, or even and 4 (2%) said they were much developing ME/CFS, after better after the jab. n Anyone with serious health problems in addition to ME/CFS this vaccine. This is possibly It is impossible to predict if such as chest (especially asthma because research into immune someone with ME/CFS is going to or bronchitis), heart, liver or kidney system dysfunction in ME/CFS experience an adverse reaction disease, diabetes, a weakened has found evidence of what is to flu vaccine. However, some immune system, or who is taking called immune system activation. doctors (myself included) believe steroid medication, is particularly This equates to a persisting and that this may be more likely if you at risk of developing serious overactive immune response to still have on-going flu-like/infection complications from flu. a triggering infection. Vaccines symptoms such as enlarged mimic the infection they are glands, sore throats, problems with n If you have already had a flu designed to protect against and temperature control, etc. vaccine while suffering from ME/ will therefore trigger an immune CFS, and not suffered any adverse system response. WHAT ARE THE effects, it is reasonable (but not guaranteed) to assume that you In a small survey carried out by GENERAL CAUTIONS & The ME Association among its should be OK this time round members a few years ago, seven CONTRA-INDICATIONS (although the viral make-up of the vaccine is changed from year to out of 21 people had no problems Flu vaccine may be contra- year). at all with flu vaccine; 13 reported indicated in people who have an exacerbation of symptoms had a previous reaction, or are n Serious adverse reactions are ranging from mild (3) or moderate allergic to eggs and poultry – as very rare although minor transient (7) through to a severe relapse in the inactivated vaccine contains problems such as malaise, three cases. Interestingly, there small amounts of egg and poultry headache and muscle pain do was also one report of a teenager proteins. This is something you sometimes occur. A full list of who noticed a slight improvement need to discuss with your doctor potential side-effects is listed later in symptoms following vaccination. because there are now egg-free in this leaflet. vaccines available. The only published research study You should also inform your doctor into adverse reactions to flu if you are allergic to any of the vaccine in people with ME/CFS possible vaccine components and concluded that people with ME/ preservatives: eg, formaldehyde, CFS were no more likely to have gentamicin sulphate and sodium a serious adverse reaction than deoxycholate. One further contra- people receiving this vaccine for indication is having an active recommended reasons. febrile illness. Reference: Influenza Vaccination: Some flu vaccines used to include Is it appropriate for Chronic thiomersil – a controversial Fatigue Syndrome? (2002) mercury-containing preservative. American Journal of Respiratory This has now been gradually Medicine (2002),1: 3-9). withdrawn from However, two case reports vaccines following involving health workers who concerns that it could developed ME/CFS after swine flu cause neurological vaccination have been reported problems. 3 © ME Association 2020. Reproduction is not allowed without the written permission of The ME Association
FLU VACCINE AND ME/CFS: INFORMATION FOR 2020 – 2021 October 2020 caught by contact with infected WHAT ARE THE surfaces, including hands – so RECOGNIZED SIDE- regular handwashing with soap – as for COVID-19 – is a sensible EFFECTS? precaution to take. Common and normally transient Sneezing into your elbow – not the side-effects include a slight palm of your hand – reduces the temperature and aching muscles risk of spreading the virus. for a couple of days after having the jab. Your arm may also feel a bit sore. If you do experience a RESEARCH INTO FLU The use of a specific adjuvant sore arm after vaccination, use known as AS03 – an emulsion VACCINES AND ME/CFS a heat pack or warm compress that was added to stimulate the The effect of influenza vaccination on the area and take a painkiller immune response in a previous on ME/CFS was examined in an such as paracetamol or ibuprofen. vaccine – has been linked to Australian pilot study which found Serious side-effects are very rare. narcolepsy. that vaccination is accompanied Recognised potential side-effects by a degree of immune system listed in the literature provided WHERE CAN YOU HAVE dysregulation in ME/CFS patients to doctors include local redness, A FLU JAB? compared to healthy controls and swelling, pain, bruising, fever, that the vaccine has the ability malaise, shivering, fatigue, Most people have a flu jab at their to increase cytotoxic activity and headache, sweating, myalgia GP surgery – where it is free if you pro-inflammatory reactions post- (muscle pain), arthralgia (joint have one of the conditions listed vaccination (Brenu et al 2012). pain), generalised skin reactions above where flu vaccination is (itching, urticaria}, neuralgia (nerve recommended by the NHS. If you However, Prinsen et al (2012) found pain), paraesthesiae (abnormal are on the list of people who are that humoral and cellular immune sensations in the skin). eligible you will probably receive responses following influenza a letter asking you to book an vaccination were comparable As many of these side-effects are in ME/CFS patients and healthy appointment at one of their flu also ME/CFS symptoms, this may controls. vaccine clinics. help to explain why some people with ME/CFS feel worse after a flu Some community pharmacies offer References: Brenu EW et al. vaccine. flu vaccination and it is now widely (2012). The effects of influenza available for a small charge (or vaccination on immune Nasal spray side-effects include a function in patients with chronic free if your are eligible) at many runny or blocked nose, headache, pharmacies such as Boots and fatigue syndrome/myalgic tiredness and loss of appetite. Lloyds. encephalomyelitis. International More serious side-effects Journal of Clinical Medicine, 3, 544 GP surgeries and pharmacies will include convulsions, transient – 551. be following the social distancing thrombocytopenia (lowered rules and only seeing one person Prinsen H et al. (2012) Humoral and level of platelets in the blood), at a time. So most will require cellular immune responses after encephalomyelitis, vasculitis some form of advance pre- influenza vaccination in patients (blood vessel inflammation), booking. If you are housebound, with chronic fatigue syndrome. neuritis (nerve inflammation) and you can ask your GP surgery if BMC Immunology, 13, 71. Guillain Barre syndrome. These someone, possibly a practice complications are much more nurse, could come out and do the PNEUMOCOCCAL unusual. vaccination in your own home. VACCINATION The flu vaccine cannot cause flu. HOW CAN YOU This vaccine is now being offered REDUCE THE RISK OF to people over the age of 65 and those with other health conditions CATCHING FLU? (e.g. heart and lung disease) that place them at increased risk from Children are a major source this bacterial infection. It provides of infection – because flu is very valuable protection against essentially a disease of childhood. an infection that can cause a So, just as with COVID-19, keep severe type of pneumonia. a safe distance – at least two metres – from anyone who is I know of a small coughing, sneezing, or may have number of people flu, and avoid crowded public with ME/CFS who places. The virus can also be have received the 4 © ME Association 2020. Reproduction is not allowed without the written permission of The ME Association
FLU VACCINE AND ME/CFS: INFORMATION FOR 2020 – 2021 October 2020 pneumococcal vaccination and we have not received any reports of significant adverse reactions occurring to this vaccine so far. ME CONNECT However, that is not a guarantee that you will not have any side- effects, or an exacerbation of your ME/CFS symptoms. If there are good indications We’re here to help 0344 576 5326 for having this protection (and a pneumococcal infection would probably cause a Do you need to talk? significant relapse of ME/CFS), ME Connect is the telephone helpline this is something that you should service of the ME Association. seriously consider and discuss with It provides information and support for your GP. people with ME and those who live with or care for them. Please note that it is normally sensible to defer being vaccinated ME Connect provides a safe and if you are currently having any understanding environment for people with ME so that they know they are significant flu-like symptoms (i.e. being heard and understood. sore throats, tender glands, feeling feverish) in relation to your ME/CFS More information on “Thank you for being there, pneumococcal vaccine can be you provide a wonderful found here: https://tinyurl.com/ service” y928j2xw “MEConnect gave me information, reassurance FURTHER and the tools to cope” ME Connect is a member of the INFORMATION Helplines Partnership which promotes high standards. The NHS website gives helpful and more detailed general guidance on flu vaccine and how to obtain CALL 0344 576 5326 flu vaccine: 10am-12noon, 2pm-4pm, 7pm-9pm https://tinyurl.com/y2tdpvna every day of the year Boots flu vaccine service: https://tinyurl.com/y5v6lcdo Calls cost the same as other standard landline numbers (starting 01 or 02). If you have a call package for your landline or mobile phone then Lloyds flu vaccine service: calls will normally come out of your inclusive minutes. https://tinyurl.com/y3rhckqv The ME Association September 2020 July 2020 August 2020 UNIVERSAL CREDITNUTRITION EXPLAINED ASSESSMENT DISCLAIMER ME CONNECT Information and Support Line IN ME/CFS A benefits briefing from The ME Association website shop: by Ann Innes ME CONNECT HELPLINE: 0344 576 5326 by Hilary Briars by Dr Charles Shepherd U ME Connect Manager Hon Medical Adviser to the MEA niversal Credit (UC) is a Universal Credit will normally be term medical conditions. And INTRODUCTION payment to help ME withCONNECT your paid monthly in a single payment, ARE SOME PEOPLE having any form of malnutrition living costs. It’s normally directly to the person making the Neil Riley, Chairman of The ME paid monthly and you Hilary may be able ME claim. Briars, Connect’s WITH M.E. AT RISK If you think you will have a has an important adverse effect Association, writes: to get it if you’re on a Manager, low income, writes:problem managing your money, on health. This includes decreased OF BECOMING Medical information contained out of work or cannot work because you can ask for fortnightly or even immune system function, decreased When you I am very proud of the fact that you are disabled. muscle strength, delayed wound are ill with ME Connect takes thousands of MALNOURISHED? weekly payments. You can also ask for your rent to go straight to your healing and an increased risk of a chronic It is a relatively new, non-taxable calls each year and I’m equally landlord. falls. The ME Association has the largest condition like benefit for people of working proud of our volunteers who There is a great deal of positive ME there are age that has been introduced respond to will be at thediscussion to theseIt calls. DWP’s discretionon ME/CFS internet It will also cause a further reduction many things replace means tested benefits as to whether they forums allowabout these the benefits of in energy levels and exacerbate in this leaflet is not intended about; giving help to those Council (excluding who TaxWe are all really pleased to be Reduction, unproven special diets, restrictive you want to requests. So any written evidence cogni-tive problems – both of need it at a difficult which time in claimed is still their able to help separately via so many people and with exclusion diets, and dietary know. What from a health professional to back which areCredit This guide to Universal very relevant in ME/CFS. lives. your local authority). ME and those who care for them. treatments up your reasons supplements. for needing help was written by Ann Innes, However, we would like to help So a proper nutritional assessment, Our volunteers do UCthatis inevery managing your finances or for selection of ME/CFS advice leaflets work, where its infancy andmore legislation (pictured above), consultant people and thus we need At the same time, very little which includes both food and can I find day. Why? Because it is intensely is changing all the time. Therefore, rental payments to your landlord, welfare rights adviser to The more volunteers to take calls.attention is being paid to the fluid intake, should form part of a doctor who understands ME, rewarding for them pleaseto help be awareothersthat the would be useful to submit with your ME Association. dangers of cutting out or reducing the medical assessment and on- to be a substitute for where can I get guidance on and they want toinformation contributein this leaflet, Thewhilst request.In a short work is rewarding. the intake of specific food groups Ann has beengoing supporting care of everyone, especially This guide to nutrition in Severe filling in my benefit claim. Even something in their lives to correct atsociety. callcould time of writing, you cango help a person with people with ME/CFS to claim their problem orCAN help a Idistressed CLAIM By helping othersout it in such as dairy or wheat. And those with moderate or severe ME/ ME/CFS was written by Dr more important is to hear another ofturn dateenriches at any time. their lives. caller get through their day. With people with more severe the ME benefits they CFS. are Andentitled it must involve a dietitian, Charles Shepherd (pictured voice, someone who understands UNIVERSAL CREDIT? in the UK on: For the very latest information to since 2012 preferably – when sheone waswho has experience how ME affects everyday life. so muchyou information to hand may and have significant problems above), Trustee and Hon I hope you will come and join can access the Govt. website here: in obtaining groceries, preparing employed byof the Stockport seeing peopleMEwith ME/CFS. Someone who will listen. an understanding You ofmust ME, be we ofcanworking age. This Medical Adviser to The ME our volunteer team. They are a https://www.gov.uk/universal-credit Group. really help people. usually means meals, and even 18 eating a full Association. medical advice or treatment lovely friendly bunch. Many have you must over The assessment should take The role of ME Connect is simple. It meal. Means-tested benefits are those She is now in account private practice is there to support people with ME or have had ME and all of them So many callers but say under pension to us “Thank age to claim. of all the factors that © The ME Association, 2020 benefits awarded to households However, in some circumstances it helping disabled people and their carers to make informed understand the illness. You’ll make you so much for giving your time, All ofit this could be having an increase the risk of malnutrition in All rights reserved. on a low income with savings and access benefits, social care choices. It is there to listen to a friends and you’ll learn a lot. Just is just so nice to isspeak possible to claim to someoneadverse fromeffect age 16. onFortheir overall vulnerable groups of people with capital below £16,000. example, people estranged from support, appropriate housing Reproduction, in full or in part, caller and try to understand all the pick up a phone or email us. We who really understands what Ihealth. am So do we need to start long-term medical conditions. their parents orlookingwho are and other services. is not allowed without the issues they are facing. Each year it would love to hear Thefrom you. means-tested going benefits UCthrough.” has atdisabled diet and nutritional Physical factors include the may be able to claim from 16 years © The copyright for this leaflet written permission of The ME replaced are: status in ME from both a clinical from your doctor. does this for thousands of people. Medical Management Many of our volunteers of age. have presence of nausea and/or loss Association. Of all that The ME Association and research point of view? remains vested with Ann Innes. of appetite, swallowing difficulties does for people with ME it is our “It is really ngoodIncome support (IS);appreciated the fact that they that you From 15 can do their training and take May 2019, if you are in a and bowel symptoms that involve the ability to obtain food Telephone Helpline of which I am n Income-based jobseeker’s offer this service, it is such a calls in their owncouple home.and SO WHAT’S THE Othersone member is below You must not bemay affect both in education digestion and unless and prepare meals. proudest. It is what a charity is all allowance (IBJSA); and the other above pension age, relief to speak ntoIncome-related someone whoemployment have said that helpline work has the couple ANSWER? will no longer be able to you are a parent,absorption of food. disabled student The assessment should record the given them anda sense of purpose or a young person on a non- factors can include understands.” support allowance (IRESA); claim pension and a feeling of job satisfaction. credit until they have This is a very important advanced Psychological question. course (e.g. A-levels, person’s normal daily intake of Mental Health both exceeded working age and depression – if this occurs – and its food and fluid in terms of total n Housing benefit (HB);Please do join us; The whole issue of nutritional GCSEs, NVQs, etc). For a full list willyou will be instead given have to claim Universal effect on appetite. Social factors calories, carbo-hydrates, proteins, assessment in people with ME/CFS, of non-advanced and advanced n Child tax credit (CTC) a warm welcome! Credit (if they meet the eligibility fats, sugars, vitamins and minerals The ME Association along with the risk of malnutrition courses, please follow this link CALLn OUR Working tax credit (WTC). criteria). in those with more severe ME/CFS, to the relevant page at the UK and micronutrients. ME CONNECT “Thank you soYour much for giving savings and capital must is something that I will be Government raising website: https://tinyurl. For example, although fruit and This means that if you are making SUPPORT LINE up your time beto work under on this £16,000. during Savings and the preparation com/y2gx58nb of the new vegetables are very healthy they ME Connect a new claim or if you are currently capital includeNICE any guideline cash, money on in ME/CFS. on any of these benefitsHelpline. and have It is just so nice to You must not already be in receipt contain very few calories. And accounts or other savings or capital 0344 576 5326 certain changes of circumstances, of Severe Disability Premium. This while dairy has become a ‘bad speak to someone you mightwhohave really Asbutthisexcludes is such an theimportant and recommends that you you will be asked to claim UC is because there is currently no food’ in the eyes of some it is home in whichneglected you live. topic, I have prepared instead of the old ‘means-tested’ 365 days a year understands what I am going a fairly detailed reply. equivalent amount in UC. People an important source of calories, equivalent. You must be on a low income. who currently receive a severe protein and calcium. Fluid intake 10am-12noon, 2pm-4pm, 7pm-9pm through.” Firstly, it’s worth noting that should be in the region of five or Diet & Nutrition The ME Association n 7 Apollo Office Court, Radclive malnutrition is surprisingly Road, Gawcott, Bucks common MK18 4DF n 01280 818 963 more cups per day of water, juice, www.meassociation.org.uk among peoplenwith admin@meassociation.org.uk chronicCharity Registered long- Number 801279 coffee, tea, etc. The ME Association n 7 Apollo Office Court, Radclive Road, Gawcott, Bucks MK18 4DF nn01280 818 963 © ME Association 2020. Reproduction is not allowed without the written permission of The ME Association always consult your doctor or www.meassociation.org.uk n admin@meassociation.org.uk n Registered Charity Number 801279 The ME Association n 7 Apollo Office Court, Radclive Road, Gawcott, Bucks MK18 4DF n 01280 818 963 © ME Association 2020. Reproduction is not allowed without the written permission of The ME Association 1 www.meassociation.org.uk n admin@meassociation.org.uk n Registered Charity Number 801279 1 © ME Association 2020. Reproduction is not allowed without the written permission of The ME Association General Information 1 healthcare professional about Fundraising Leaflets any specific problem. Benefits & Social Care We also recommend that ‘To Whom It May Concern’ letters any medical information You can download leaflets and buy provided by The MEA is, where gifts from our website shop: https:// appropriate, shown to and meassociation.org.uk/shop discussed with your doctor. 5 © ME Association 2020. Reproduction is not allowed without the written permission of The ME Association
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