FIXED INCOME INVESTORS PRESENTATION - It's time to build together a better future for you - Banco Santander

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FIXED INCOME INVESTORS PRESENTATION - It's time to build together a better future for you - Banco Santander
Q1 2022

FIXED INCOME
INVESTORS
PRESENTATION
It's time to build together a
better future for you
FIXED INCOME INVESTORS PRESENTATION - It's time to build together a better future for you - Banco Santander
Important information
Non-IFRS and alternative performance measures

This presentation contains, in addition to the financial information prepared in accordance with International Financial Reporting Standards (“IFRS”) and derived from our financial statements, alternative
performance measures (“APMs”) as defined in the Guidelines on Alternative Performance Measures issued by the European Securities and Markets Authority (ESMA) on 5 October 2015
(ESMA/2015/1415en) and other non-IFRS measures (“Non-IFRS Measures”). These financial measures that qualify as APMs and non-IFRS measures have been calculated with information from Santander
Group; however those financial measures are not defined or detailed in the applicable financial reporting framework nor have been audited or reviewed by our auditors. We use these APMs and non-IFRS
measures when planning, monitoring and evaluating our performance. We consider these APMs and non-IFRS measures to be useful metrics for our management and investors to compare operating
performance between accounting periods, as these measures exclude items outside the ordinary course performance of our business, which are grouped in the “management adjustment” line and are
further detailed in Section 3.2 of the Economic and Financial Review in our Directors’ Report included in our Annual Report on Form 20-F for the year ended 31 December 2021. Nonetheless, these APMs
and non-IFRS measures should be considered supplemental information to, and are not meant to substitute IFRS measures. Furthermore, companies in our industry and others may calculate or use APMs
and non-IFRS measures differently, thus making them less useful for comparison purposes. For further details on APMs and Non-IFRS Measures, including its definition or a reconciliation between any
applicable management indicators and the financial data presented in the consolidated financial statements prepared under IFRS, please see the 2021 Annual Report on Form 20-F filed with the U.S.
Securities and Exchange Commission (the “SEC”) on 1 March 2022, as updated by the Form 6-K filed with the SEC on 8 April 2022 in order to reflect our new organizational and reporting structure, as well
as the section “Alternative performance measures” of the annex to the Banco Santander, S.A. (“Santander”) Q1 2022 Financial Report, published as Inside Information on 26 April 2022. These documents
are available on Santander’s website (www.santander.com). Underlying measures, which are included in this presentation, are non-IFRS measures.

The businesses included in each of our geographic segments and the accounting principles under which their results are presented here may differ from the included businesses and local applicable
accounting principles of our public subsidiaries in such geographies. Accordingly, the results of operations and trends shown for our geographic segments may differ materially from those of such
subsidiaries.

Forward-looking statements

Santander advises that this presentation contains “forward-looking statements” as per the meaning of the U.S. Private Securities Litigation Reform Act of 1995. These statements may be identified by
words like “expect”, “project”, “anticipate”, “should”, “intend”, “probability”, “risk”, “VaR”, “RoRAC”, “RoRWA”, “TNAV”, “target”, “goal”, “objective”, “estimate”, “future” and similar expressions. Found
throughout this presentation, they include (but are not limited to) statements on our future business development, economic performance and shareholder remuneration policy. However, a number of
risks, uncertainties and other important factors may cause actual developments and results to differ materially from our expectations. The following important factors, in addition to others discussed
elsewhere in this presentation, could affect our future results and could cause materially different outcomes from those anticipated in forward-looking statements: (1) general economic or industry
conditions of areas where we have significant operations or investments (such as a worse economic environment; higher volatility in the capital markets; inflation or deflation; changes in demographics,
consumer spending, investment or saving habits; and the effects of the war in Ukraine or the COVID-19 pandemic in the global economy); (2) exposure to various market risks (particularly interest rate risk,
foreign exchange rate risk, equity price risk and risks associated with the replacement of benchmark indices); (3) potential losses from early repayments on our loan and investment portfolio, declines in
value of collateral securing our loan portfolio, and counterparty risk; (4) political stability in Spain, the United Kingdom, other European countries, Latin America and the US (5) changes in legislation,
regulations, taxes, including regulatory capital and liquidity requirements, especially in view of the UK exit of the European Union and increased regulation in response to financial crises; (6) our ability to
integrate successfully our acquisitions and related challenges that result from the inherent diversion of management’s focus and resources from other strategic opportunities and operational matters; and
(7) changes in our access to liquidity and funding on acceptable terms, in particular if resulting from credit spreads shifts or downgrade in credit ratings for the entire Group or significant subsidiaries.

                                                                                                                                                                                                            2
FIXED INCOME INVESTORS PRESENTATION - It's time to build together a better future for you - Banco Santander
Important information
Numerous factors could affect our future results and could cause those results deviating from those anticipated in the forward-looking statements. Other unknown or unpredictable factors could cause
actual results to differ materially from those in the forward-looking statements.

Forward-looking statements speak only as of the date of this presentation and are informed by the knowledge, information and views available on such date. Santander is not required to update or revise
any forward-looking statements, regardless of new information, future events or otherwise.

No offer

The information contained in this presentation is subject to, and must be read in conjunction with, all other publicly available information, including, where relevant any fuller disclosure document
published by Santander. Any person at any time acquiring securities must do so only on the basis of such person’s own judgment as to the merits or the suitability of the securities for its purpose and only
on such information as is contained in such public information having taken all such professional or other advice as it considers necessary or appropriate in the circumstances and not in reliance on the
information contained in this presentation. No investment activity should be undertaken on the basis of the information contained in this presentation. In making this presentation available Santander gives
no advice and makes no recommendation to buy, sell or otherwise deal in shares in Santander or in any other securities or investments whatsoever.

Neither this presentation nor any of the information contained therein constitutes an offer to sell or the solicitation of an offer to buy any securities. No offering of securities shall be made in the United
States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. Nothing contained in this presentation is intended to constitute an invitation or
inducement to engage in investment activity for the purposes of the prohibition on financial promotion in the U.K. Financial Services and Markets Act 2000.

Historical performance is not indicative of future results

Statements about historical performance or accretion must not be construed to indicate that future performance, share price or results (including earnings per share) in any future period will necessarily
match or exceed those of any prior period. Nothing in this presentation should be taken a profit forecast.

Third Party Information

In particular, regarding the data provided by third parties, neither Santander, nor any of its administrators, directors or employees, either explicitly or implicitly, guarantees that these contents are exact,
accurate, comprehensive or complete, nor are they obliged to keep them updated, nor to correct them in the case that any deficiency, error or omission were to be detected. Moreover, in reproducing these
contents by any means, Santander may introduce any changes it deems suitable, may omit partially or completely any of the elements of this document, and in case of any deviation between such a
version and this one, Santander assumes no liability for any discrepancy.

                                                                                                                                                                                                         3
FIXED INCOME INVESTORS PRESENTATION - It's time to build together a better future for you - Banco Santander
Index

   1            2          3          4         5          6             7             8
Santander      Q1’22    Santander   Capital    Asset    Liquidity &   Concluding      Links,
at a Glance   Summary    Business             Quality    Funding.      Remarks      Appendix
                         Model &                          Ratings                  and Glossary
                         Strategy

                                                                                         4
FIXED INCOME INVESTORS PRESENTATION - It's time to build together a better future for you - Banco Santander
Santander at a Glance
                                              Q1’22 Highlights
 Santander, a           Total assets (€ bn)                                          1,666
 leading financial      Customer loans (€ bn excluding reverse repos)                 998

 group                  Customer deposits + mutual funds (€ bn; excluding repos)     1,097
                        Branches                                                     9,898

                        Q1'22 Net operating income (pre-provision profit) (€ mn)     6,770

 Simple Personal Fair   Q1'22 Underlying attributable profit (€ mn)                  2,543
                        Q1'22 Attributable profit (€ mn)                             2,543

                        Market capitalization (€ bn; 31-03-22)                         54

                        People (headcount)                                         198,204

                        Customers (mn)                                                155

                        Shareholders (mn)                                              4.0

                        Communities 2019-2021 (mn; financially empowered people)       7.5

                                                                                             5
FIXED INCOME INVESTORS PRESENTATION - It's time to build together a better future for you - Banco Santander
Index

    1           2          3          4         5          6             7             8
Santander      Q1’22    Santander   Capital    Asset    Liquidity &   Concluding      Links,
at a Glance   Summary    Business             Quality    Funding.      Remarks      Appendix
                         Model &                          Ratings                  and Glossary
                         Strategy

                                                                                         6
FIXED INCOME INVESTORS PRESENTATION - It's time to build together a better future for you - Banco Santander
Q1’22 Summary

Q1’22 highlights
   Growth
  • We increased our customer base (+7mn YoY), digital customers (+11% YoY) and digital sales (56% of total sales vs. 50% in Q1’21)

  • Commercial activity1 remained robust, up QoQ and YoY (loans +5%; deposits +5%; mutual funds +6%)
  • We continued to grow revenue1, achieving solid year-on-year growth rates (NII +6% and net fee income +6%). Net operating income up to €6.8bn

   Profitability
  • Q1’22 attributable profit of €2,543mn (+19% vs Q1’21 underlying profit; +12% in constant euros). Including restructuring costs in Q1’21, +58% in euros

  • Cost discipline and greater productivity led to an efficiency ratio of 45.0%
  • Improved profitability QoQ and YoY (RoTE of 14.2% and EPS of €14.1 cents, +22% vs. Q1’21 underlying EPS)

  • Outstanding TNAV performance: TNAVps of €4.29. TNAV + Cash DPS: +13% YoY

   Strength
  • Ongoing risk management: cost of credit at 0.77%; NPL ratio of 3.26%; loan-loss reserves of €25bn

  • FL CET1 ratio of 12.05%2 with a net organic generation of 17bps in the quarter(+40bps from earnings and -23bps from dividend accrual and second share
    buyback)

                   Our business model’s unique diversification continues to prove its resiliency
                    in generating growth and profit while maintaining balance sheet strength
                   (1) YoY changes in constant euros. In euros: loans: +8%; deposits: +8%; mutual funds: +13%; NII: +11%; net fee income: +10%       7
                   (2) Including the acquisition of Amherst Pierpont which completed in April 2022
FIXED INCOME INVESTORS PRESENTATION - It's time to build together a better future for you - Banco Santander
Q1’22 Summary

Profit growth underpinned by our geographic and business diversification

                                                                                                                                        Underlying       Contribution
                                                                                                                                        att. profit2      to Group’s
                                                                              % change                            Q1’22 vs. Q1’21          (€ mn)      underlying profit3
€ million                                  Q1'22          Q1'21             Euros Constant euros
                                                                                                                                           1,018
NII                                          8,855          7,956             11              6                              Europe                            34%
Net fee income                               2,812          2,548             10              6                                            +30%
Trading and other income                       638            886            -28           -31
Total revenue                              12,305         11,390                8             3                              North          806
                                                                                                                                                              27%
Operating expenses                          -5,535        -5,118                8             4                              America        +4%
Net operating income                         6,770          6,272               8             2
LLPs                                        -2,101        -1,992                5             1
Other results                                 -498           -467               7             5                              South          900               30%
Underlying PBT                               4,171          3,813               9             3
                                                                                                                             America        +8%
Underlying att. profit                       2,543          2,138             19            12
Net capital gains and provisions¹                  0         -530          -100           -100                     Digital   Digital        282
Attributable profit                          2,543          1,608             58            47
                                                                                                                  Consumer   Consumer                          9%
                                                                                                                    Bank
                                                                                                                             Bank          +11%

                      (1) Q1'21: restructuring costs (net of tax), corresponding mainly to the UK and Portugal                                                              8
                      (2) Changes in constant euros. North America change excluding Bluestem portfolio disposal
                      (3) Contribution as a % of operating areas, excluding the Corporate Centre
FIXED INCOME INVESTORS PRESENTATION - It's time to build together a better future for you - Banco Santander
Q1’22 Summary

Positive profit trend backed by higher revenue, cost discipline and flat LLPs

                   Attributable profit                                                                 Revenue
                                                              Constant € mn
Constant € mn
                                                                                                                   8,986
                                                                                                                               8,855   +6%
                                                                                                           8,685
                                                                 NII           8,335
                                                                                                8,551                                  YoY
                                                   +47% YoY

                                                                                                                   2,766       2,812   +6%
                                                     2,543     Net fee
                                           2,357               income          2,655
                                                                                                2,706      2,689                       YoY
       2,275        2,194         2,245

                                                                Other           928                        858                 638
                                                                                                 474               375
                                                               income
       1,732

                                                                                                           5,514
                                                                                                                   5,765
                                                                                                                               5,535   +4%
                                                                                5,297            5,413
      Q1'21           Q2           Q3       Q4       Q1'22      Costs                                                                  YoY
             Underlying profit

                                                                LLPs            2,086                      2,287
                                                                                                                               2,101   +1%
                                                   +58% YoY                                       1,824                    1
   Attributable profit (current € mn)                                                                              1,524               YoY
     1,608         2,067         2,174    2,275     2,543
                                                                                Q1'21              Q2        Q3      Q4        Q1'22

                                                                (1) Includes overlay partial release

                                                                                                                                       9
FIXED INCOME INVESTORS PRESENTATION - It's time to build together a better future for you - Banco Santander
Q1’22 Summary

We continue to make structural changes to our operating model, driving
sustainable efficiencies and mitigating the effects of higher inflation

                                    Group                                                                   Cost by region
                                                                                        Q1’22 vs. Q1’21
                                                                                                                             In real terms1

  Total costs
   Q1’22 vs. Q1’21
                                     +4.5%                         -3.3%                           Europe           -2.0%     -6.6%
                                                                       in real terms1
                                                                                                   North America    +2.6%     -3.7%

                                                                                                   South America   +15.6%    +0.5%
                                   45.0%                          -1.2pp
   Efficiency                                                                              DCB
                                                                                                   Digital
                                                                                                                    +6.8%    +3.0%
   Q1’22 vs. FY’21                  Improvement mainly driven by                                   Consumer Bank
                                      Europe (-4.4pp to 47.8%)

                     Note: changes in constant euros                                                                                   10
                     (1) Excluding the impact from average inflation
Q1’22 Summary

Cost of credit remained well below 1%. In Q1, LLPs normalizing after
releases in Q4’21
                Loan-loss provisions                                                                                            Credit quality indicators
Constant € bn

                                                                                                                                   Mar-21                           Dec-21   Mar-22

                                                                                              Cost
                                                                                              of credit2
                                                                                                                                   1.08%                            0.77%    0.77%
                                  2.3
      2.1                                                            2.1
                 1.8
                                                  1.5
                                                                                              NPL ratio                            3.20%                            3.16%    3.26%3

                                                                                              Coverage
                                                                                              ratio
                                                                                                                                     74%                            71%      69%3
     Q1'21       Q2               Q3                Q41            Q1'22

                      (1) Includes overlay partial release                                                                                                                       11
                      (2) Provisions to cover losses due to impairment of loans in the last 12 months / average customer loans and advances of the last 12 months
                          Considering annualized Q1'21 provisions, cost of credit would be 0.83%
                      (3) New definition of default (NDD) applied in Q1’22 (impact on the NPL ratio of +19bps)
Q1’22 Summary

Organic generation in Q1 led to an increase in the FL CET1 ratio to >12%

                                       Fully-loaded CET1 ratio quarterly evolution
%
                                             +0.40
                                                                                                                                                                               12.05
                11.96                                                         -0.23                                                            -0.05
                                                                                                               -0.03

             Dec-21                      Gross organic                    Shareholder                       Regulatory                        Markets                         Mar-22
                      1
            Pro forma                     generation                     remuneration 2                      & Models                         & others                       Pro forma 1

                                                                                          Q1'21            Q1'22            Diff.
                                                                                                                    1
                                                          FL CET1 ratio                  11.85%            12.05%          19 bps
                                                                                                                    1
                                                          FL Total capital ratio         15.77%            16.08%          30 bps
                                                          FL Leverage ratio               4.91%            5.03%           12 bps

                   (1)   Pro forma: Including acquisition of SC USA minority interest which closed on 31 January 2022 and the acquisition of Amherst Pierpont which completed in April 2022    12
                   (2)   Including a 15bp charge from the second share buyback corresponding to 2021, and an 8bp charge from the cash dividend accrual, corresponding to 20% of Q1'22 profit
Q1’22 Summary

Outstanding QoQ and YoY profitability. TNAVps + cash dividend: +13% YoY

        Underlying RoTE                                                 Underlying EPS                                                           TNAV per share
                                                          €cents
                                                          EUR cents                                                                EUR

                                  14.2%                                                                  14.1                                                                     4.29
      13.0%     12.7%                                                                  12.4                                                                    4.12
                                                                    11.6
                                                                                                                                            3.84

      Q1'21      FY21              Q1'22                            Q1'21             Q4'21              Q1'22                             Mar-21             Dec-21             Mar-22

 Statutory                                                 Statutory
                                                                                                                                Note: including €4.85 cents from the cash dividend paid in November
      12.2%     12.0%             14.2%                         8.5                   12.4                 14.1                 2021, TNAVps + Cash dividend up 13% YoY

                Note: the averages for the Q1 RoTE denominators are calculated on the basis of 4 months from December to March and 2021 RoTE denominator is calculated on the basis of            13
                13 months from December to December. For periods of less than a year, and in the event of items outside the ordinary performance of our business, the profit used to
                calculate the statutory RoTE is the annualized underlying attributable profit (excluding these results), to which these results are added without annualizing them
Index

    1           2         3           4         5          6             7             8
Santander      Q1’22    Santander   Capital    Asset    Liquidity &   Concluding      Links,
at a Glance   Summary    Business             Quality    Funding.      Remarks      Appendix
                         Model &                          Ratings                  and Glossary
                         Strategy

                                                                                        14
Santander Business Model & Strategy

          Santander is managed according to primary and secondary segments

                                                                                                                                                                                  One Santander (Europe, North
                                                                            Primary segments
                                                                                                                                                                              

                                                                                                                                                                                  America and South America). New
                                                                                                                                                                                  operating model leveraging our
                          Europe                            North America                                   South America              Digital Consumer Bank
                                                                                                                                                                                  global scale to deliver a better
                  Spain               UK                     United States                         Brazil             Uruguay                        SCF                          customer experience, supported by
                                                                                                                                                                                  common culture and higher degrees
                  Portugal            Poland                 Mexico                                Chile              Peru
                                                                                                                                                                                  of commonality, technology being
                          Other Europe                                                             Argentina          Colombia                                                    one
More details in                                                                                                                                                                  Digital Consumer Bank: our vision is
Appendix:                                                                                                                                                                         to become the largest digital
                                                                                                                                                                                  consumer bank in the world

                                                                                                                                                                                  Global businesses (SCIB and WM&I)
                                                                          Secondary segments
                                                                                                                                                                              

                                                                                                                                                                                  to enhance our local scale with global
              Retail Banking                                     SCIB                                         WM&I                               PagoNxt                          reach and collaboration
                                                                                                                                                                                 PagoNxt: innovative payments
                                                                                                                                                                                  solutions for both Santander and
                                                  Group functions and Corporate Centre activities                                                                                 non-Santander clients

                                                Communication,                                                                                                     Exec.         The Corporate Centre and other
                                                                                                       Technology    Financial                 Strategy,
    Audit Compliance        Risk Universities     Corporate    Costs   General     Human
                                                                                                           &         Control /   Finance    Corporate Dev.&
                                                                                                                                                                Chairman’s        functions servicing the whole Group
                                                 Marketing and       Secretariat1 Resources                                                                      Office &
                                                                                                       Operations   Accounting             Financial Planning   Responsible
                                                   Research
                                                                                                                                                                  Banking

                                         (1) Includes Legal, Governance, Tax and Security & Intelligence.                                                                                                   15
Santander Business Model & Strategy

    Our business model drives predictable and profitable growth
                                                              Our business model is based on three pillars
 01. Scale                                                                           02. Customer focus                                                         03. Diversification2
 Local scale and leadership.                                                         Unique personal banking relationships                                      Our geographic and business
 Worldwide reach through our global                                                  strengthen customer loyalty                                                diversification makes us more resilient
 businesses and PagoNxt                                                                                                                                         under adverse circumstances
                                                                         Digital
                                                                     Consumer Bank

                                                                                                                                                                                                          1,018
                                                                          #1
                                                                                                                                                                                  Europe                                    34%
                                                 10%                   European                                                                                                                          +30%

                                                                                                         Top 3
                                                  Loans                Consumer
                                                  8%                     Bank
                                                 Deposits

                    4%                                                  12%
                                                                                                                                                                                  North                    806
                                                                                                                                                                                                                            27%
              Auto lending

                    2%                  18%
                                                                        Loans
                                                                                                                                                                                  America                 +4%
                                                                        11%
                Deposits                Loans

                                        14%
                                                                       Deposits                in   NPS1      in 8 markets
14%                                   Deposits              17%
                                                                                                                                                                                  South                    900
 Loans                                                       Loans

13%                                                         18%                                                                                                                                                             30%
Deposits
                                   10%
                                                            Deposits
                                                                                                                                                                                  America                 +8%
                                      Loans

           18%
                                   10%
                                  Deposits                                                                                                                          Digital       Digital                  282
            Loans                                                                                                                                                  Consumer       Consumer                                  9%
           18%               11%                                                                                                                                     Bank
                                                                                                                                                                                  Bank                   +11%
           Deposits           Loans

                             11%
                             Deposits

                                  (1) Internal benchmark of individual customers' satisfaction audited by Stiga / Deloitte in H2’21.
                                  (2) Q1’22 underlying attributable profit by region, YoY growth in constant euros and % operating areas ex. Corporate Centre. North America change excluding Bluestem portfolio disposal
                                  Market share data: as at Dec-21 and Argentina, Brazil, USA and DCB latest available. Spain includes Santander España (public criteria) + Hub Madrid + SCF España + Openbank and Other     16
                                  Resident sectors in deposits. The UK includes London Branch. Poland: including SCF business in Poland. The US: Retail auto lending in all states where Santander Bank operates. Brazil:
                                  deposits including debenture, LCA (agribusiness notes), LCI (real estate credit notes), financial bills (letras financeiras) and COE (certificates of structured operations).
Santander Business Model & Strategy

Our geographic and business diversification both in assets …

          Loans and advances to customers by area                                            Loans and advances to customers by business
Breakdown of total gross loans excluding reverse repos, % of operating areas Mar-22   Breakdown of total gross loans excluding reverse repos, Mar-22

                          DCB                                                                                    1
                                                                                                          SCIB
                                                                                                                     16%
                                12%
     South                                                                                                                                     35%
                                                                                                                                                        Home
     America                                                                              Corporates 11%                                                mortgages
                    15%

                                                           59%    Europe                                 10%
                                                                                              SMEs
     North            14%
                                                                                                                                         9%
     America                                                                                                               19%
                                                                                                                                              Other
                                                                                                            Consumer                          individuals

Total gross loans excluding reverse repos: €998bn
                                                                                      84% of loan portfolio is Retail, 16% Wholesale
RWAs: €599bn

                          (1) SCIB and institutions.                                                                                                                17
Santander Business Model & Strategy

… and in liabilities …

                       Customer funds by area                                                        Customer funds by business
Breakdown of total customer funds excluding repos, % of operating areas Mar-22   Breakdown of total customer funds excluding repos, Mar-22

                                    DCB
                                                                                                              1
                                                                                                       SCIB
        South                          5%                                                                     17%
        America
                          17%
                                                                                     Corporates
                                                                                                                                          36%   Individuals
                                                                                                    9%                                          demand
                                                                                                                                                deposits

     North          13%
     America                                                                             SMEs       10%
                                                         65%     Europe
                                                                                                                                     6%
                                                                                                              10%
                                                                                            Consumer
                                                                                                                            12%

                                                                                                                  Individuals     Individuals
                                                                                                                  mutual          time
                                                                                                                  funds           deposits

                          (1) SCIB and institutions.                                                                                                          18
Santander Business Model & Strategy

… coupled with our regional organizational structure, delivers growth
and profitability…
   Q1’22                               Total                    Customer                     Customer                  Net operating                  Underlying
   vs. Q1’21                         customers                    loans                      deposits                    income1                      att. profit1            RoTE2
                                          (mn)                       (€bn)                       (€bn)                         (€mn)                       (€mn)

                                        46.1                         584                          604                        2,245                        1,018               13.5%
               Europe
                                           --                        +4%                          +5%                         +12%                         +30%               +3.0 pp

               North                    25.1                         141                          119                        1,535                          806               24.5%
               America                   +3%                         +8%                          +7%                          -4%                          +4%               -0.4 pp

               South                    64.4                         149                          124                        2,711                          900               26.7%
               America                  +11%                         +9%                          +6%                          +7%                          +8%               +0.7 pp

               Digital
   Digital
  Consumer     Consumer                 19.2                         117                            57                         667                          282               12.7%
    Bank
               Bank                        --                        +1%                          +6%                          +3%                         +11%               +1.5 pp

                    Note: YoY changes in constant euros. Loans and advances to customers excluding reverse repos. Customer deposits excluding repos                                     19
                    (1) North America excluding Bluestem portfolio disposal impact in % changes. Otherwise, net operating income -10% and underlying attributable profit 0%
                    (2) Adjusted RoTEs: adjusted based on Group’s deployed capital calculated as contribution of RWAs at 12%
Santander Business Model & Strategy

… which is resilient throughout the cycle…

                                                     Resilient profit generation throughout the cycle
      Group pre-provision profit, € bn

                                                                                                       25.5   25.6   26.2
                                                             24.4                                                                  25.0
                                                      23.9          23.6                 23.7                               23.6
                                              23.0                                22.6          22.8
                                                                           19.9
                                     17.7
                            14.8

                  11.4

                 2006       07           08   09       10    11     12     13     14     15     16     17     18     19     20     21

                                                                                                                                          20
Santander Business Model & Strategy

… resulting in long-term stable and predictable growth
               Predictable results with the lowest volatility among peers coupled with growth in earnings
 Quarterly reported EPS volatility1, 1999-Q4’21

                654%           323%

                                               116%
                                                                102%
                                                                                  93%
                                                                                                    83%              80%

                                                                                                                                      43%              40%             40%

                                                                                                                                                                             12%

                 US              IT               CH               CH               US                FR               FR               US                NL           US

                       (1) Source: Bloomberg, with GAAP Criteria. Note: Standard deviation of the quarterly EPS starting from the first available data since Jan-99.               21
Santander Business Model & Strategy

Moreover, we are able to generate profit efficiently, with one of the best C/I
ratios and net operating income /loans well above most European peers…
                                           Efficiency                                                                                         Net operating income/Loans
         Cost-to-income, Peers FY 2021, Santander Q1’22                                                                      %, European peers FY 2021, Santander Q1’22

              Peer 1                         45%

                                                                           12 pp
                                                                                                                                 Peer 1                                                           3.7
                                             45%

              Peer 2                          48%
                                                                         better than                                                                                                     2.6
                                                                          peer avg.
                                                                                                                                 Peer 2                                            2.2
              Peer 3                               53%

              Peer 4                                 56%
                                                                                                                                 Peer 3                                      2.0

              Peer 5                                   58%
                                                                                                                                 Peer 4                                      1.9

              Peer 6                                   58%
                                                                                                                                 Peer 5                                1.7

              Peer 7                                     61%
                                                                                                                                 Peer 6                        1.2

              Peer 8                                        65%

              Peer 9                                         65%

                       Note: Peers included are: BBVA, BNP Paribas, Citibank, Credit Agricole, HSBC, ING, Itaú, Scotiabank and Unicredit. Santander calculations using publicly available data.         22
Santander Business Model & Strategy

… while doing business sustainably and responsibly
                                                          Supporting the green transition…
       Green finance1                                                   AuM in sustainable funds2                                                         Decarbonization targets
 €69bn since 2019                                                            €27bn Mar-22                                                          0.23 tCO2e/MWh5 in 2019
         €3.6bn in Q1’22
                                                                                 €100bn by 2025                                                                      0.18 by 2025
        €120bn by 2025
        €220bn by 2030
                                                                                                                                                                     0.11 by 2030

       Green products                                                          Renewable energy
                                                                                                                                                         Thermal coal-related power6
>€1bn in electric vehicles                                    8 wind farm3 agreements in Q1’22                                                               & mining phase out

>€2bn in green buildings                                              Alliance with Enel                                                                         €7bn in 2021
            in Q1’22                                            Acquisition of 80% WayCarbon4                                                                           0 by 2030

…whilst engaging top management with ESG goals: 20% of long-term incentives in scorecard
                  Note: Q1’22 data not audited
                  (1) Only SCIB global business
                  (2) AuMs classified as Article 8 and 9 funds (SFDR) from SAM, plus third-party funds and other ESG products according to EU taxonomy from Private Banking. We apply equivalent ESG
                      criteria to SAM's funds in Latin America
                  (3) In the UK, Portugal and Poland with a power of 1,570 MW
                  (4) In April 2022, Banco Santander completed the acquisition of 80% of WayCarbon Soluções Ambientais e Projetos de Carbono (‘WayCarbon’), a leading Brazil-based ESG consultancy firm
                                                                                                                                                                                                          23
                  (5) Reduce emissions intensity in our power generation portfolio
                  (6) Refers to power generation clients with over 10% of their revenue depending on thermal coal
Index

    1           2          3         4          5          6             7             8
Santander      Q1’22    Santander   Capital    Asset    Liquidity &   Concluding      Links,
at a Glance   Summary    Business             Quality    Funding.      Remarks      Appendix
                         Model &                          Ratings                  and Glossary
                         Strategy

                                                                                        24
Capital

  Disciplined capital allocation strategy to drive profitability improvement &
  maximize shareholder returns…

                                                               2021                2022E
                                                                                                          RoTE >13%
       Capital
     accretive
                           RWA growth
                            below loan                  +1% < +4%              RWA
                                                                                       <   low-single   Capital generation...

                             growth2                    RWAs          loans   growth          digit
      growth                                                                                               ... to maintain
                                                                                                        FL CET1 ~12%
  Risk
Risk   adjusted
     adjusted                                                          1
     new
   new    credit
        credit
     production
                            Front book
                             RoRWA
                                                           1.8%                    2.2%
   production
                                                                                                         Maximize
    Granular                                                                                            shareholder
 profitability
                         % of RWAs with
                          RoRWA < CoE                          30%                ~20%                    returns
management

                   (1) 2019-21 average.                                                                                  25
                   (2) 2021 vs. 2020 in constant EUR.
Capital

…leading to even greater shareholder value creation going forward

             Disciplined capital allocation will improve profitability
                  leading to strong shareholder value creation

                                                                                                      …making share buybacks a
          To deliver TNAVps                                                                           meaningful remuneration
              growth…                                                                                  tool while growing cash
                                                                                                              dividend

          Note: 40% target in 2022. Longer term, we aspire to increase total shareholder remuneration beyond 40%, with around 50% through share buybacks and a growing cash dividend,
          while maintaining a FL CET1 of ~12%. Implementation of shareholder remuneration policy is subject to future corporate and regulatory decisions and approvals.                 26
Capital

Santander’s capital levels, both phased-in and fully loaded, exceed
minimum regulatory requirements
                SREP capital requirements and MDA*                                                                      Assumed capital requirements (fully-loaded)**
Mar-22                                                                                                          Mar-22
                                                              16.39%

                                                                2.54%          T2                                                                                 16.08%
                 13.01%                +338 bps                                                                                                                                                    >15%
                                                                               AT1
                                       +321 bps                 1.52%                                                             13.01% +306 bps                   2.51%
                                                                                                                                                                                                   2.00%       T2
          T2       2.38%
                                                                                                                                                                    1.52%
                                                                                                                           T2                  +293
                                                                                                                                               +319bps
                                                                                                                                                    bps                                            1.50%       AT1
        AT1        1.78%
                                       +347 bps                                                                                     2.38%

G-SIB buffer       1.00%                                                                                                 AT1        1.78%      +319
                                                                                                                                               +319bps
                                                                                                                                                    bps
                                     CCyB,                                                                      G-SIB buffer        1.00%
       CCoB        2.50%                   1
                                     0.01%                     12.33%          CET1                                                                CCyB,
                                                                                                                                    2.50%
   Pillar 2 R      0.84%
                                                                                                                        CCoB                       0.01%           12.05%                          11-12%      CET1
                                                                                                                                    0.84%
                                                                                                                    Pillar 2 R
                   4.50%
     Pillar 1                                                                                                                       4.50%
                                                                                                                      Pillar 1

           Regulatory Requirement                        Group ratios Mar-22                                                 Assumed regulatory             Group ratios Mar-22                Medium-term
                    2022                                                                                                      requirement 2022                                                 target ratios

  Following regulatory changes in response to the covid-19 crisis,                                                AT1 and T2 ratios are planned to be above 1.5% and 2% of RWAs
       the minimum CET1 to be maintained by the Group is 8.85%                                                         respectively
       (was 9.69% pre-changes)
  As of Mar-22, the distance to the MDA is 321 bps2 and the CET1
       management buffer is 347 bps
                        * The phased-in ratio includes the transitory treatment of IFRS 9, calculated in accordance with article 473 bis of the Capital Requirements Regulation (CRR2) and subsequent modifications
                           introduced by Regulation 2020/873 of the European Union. Total phased-in capital ratios include the transitory treatment according to chapter 4, title 1, part 10 of the CRR2.
                        ** Fully-loaded CRR and fully-loaded IFRS 9. Pro forma including the acquisition of Amherst Pierpont which completed in April 2022
                        (1) Countercyclical buffer as of Dec-21.                                                                                                                                                      27
                        (2) MDA trigger = 3.47% - 0.26% = 3.21% (26 bps of AT1 shortfall is covered with CET1).
Capital

Strong fundamentals for AT1 bond holders

                    Santander Group’s CET1 levels are well above the minimum loss absorption trigger of 5.125%: €43bn
Distance1to
 trigger            The first line of defense is the Group’s strong pre-provision profitability providing a high capacity to absorb provisions
                         during the crisis and should continue to underpin the Group’s earnings generation capacity

                    As of Mar-22, the distance to the MDA is 3.21%2
    MDA
                    Targeting a comfortable management buffer, in line with Santander’s business model and predictable results

                    Santander Parent Bank has c. €55bn in Available Distributable Items, best-in-class.

                    This amount of ADI represents >110 times the full Parent AT1 cost budgeted for 2022
    ADIs
                    Santander has never been prohibited from making a Tier 1 payment or dividend due to insufficient ADIs. Santander has
                         never cancelled the payment of coupons of any of its Tier 1 securities

              (1) CET1 level below which AT1 capital instruments must either convert into ordinary shares or have their principal about written down
              (2) MDA trigger = 3.47% - 0.26% = 3.21% (26 bps of AT1 shortfall is covered with CET1).                                                  28
Capital

AT1 issuances distributed by call date
                                          AT1 issuances outstanding at Mar-22
                                                        Nominal                             Next call    Reset
                     EUR mn                Currency      EUR           Coupon   Structure      date      Spread
               Banco Santander S.A.          EUR         1,000         5.25%      PNC6      29-Sep-23 499.9 bps
               Banco Santander S.A.          EUR         1,500         4.75%      PNC7      19-Mar-25 409.7 bps
               Banco Santander S.A.          EUR         1,500         4.38%      PNC6      14-Jan-26   453.4 bps
               Banco Santander S.A.          USD         1,080         7.50%      PNC5      08-Feb-24   498.9 bps
               Banco Santander S.A.          USD              900      4.75%      PNC6      12-May-27 375.3 bps
               Banco Santander S.A.          EUR              750      4.13%      PNC7      12-May-28 431.1 bps
               Banco Santander S.A.          EUR         1,000         3.63%      PNC8      21-Sep-29   376 bps

                                                                    Call date
                                                               1,500    1,500

                                             1,000    1,080                                     1,000
                                                                                900
                                                                                         750

                                      -

                                2022 2023 2024 2025 2026 2027 2028 2029                                             29
Capital

FX hedging policy on capital ratio and P&L
                Stable capital ratio hedge                                     Our P&L Policy

     Hedged
     Exposure                                     Group      Strategic management of the exposure to exchange
                                                   CET1
                                                 12.33%1
                                                               rates on equity and dynamic on the countervalue of
                                                               the units’ annual results in euros.

                                                             Mitigate impact of FX volatility.

                                                             Corporate Centre assumes all hedging costs.

  Managed to mitigate FX volatility in our CET1 ratio
  Based on Group regulatory capital and RWAs by currency

                (1) Phased-in ratio                                                                                 30
Capital

Interest rate risk hedging

          Mostly positive interest rate sensitivity                                               ALCO portfolios reflect our geographic diversification
Net interest income sensitivity to a +/-100 bp parallel shift                                    Distribution of ALCO portfolios by country
€ mn, Feb-22                                                                                     %, Mar-22

                  +100 bps                    -100 bps                                                                              Other     SCF,
                                                                                                                                  S.Am., 5%   6%     Spain,
                                                                                                                        Chile,
                     +590                          -593                                                                                               4%
              1
                                                                                                                                                              UK,
                                                                                                                        10%
                                                                                                                                                              5%

              2
                     +242                          -330                                                                                                             Poland,

                                                                                                              Brazil,               €96bn                            15%

                                                                                                               19%
                                                                                                                                 o/w HTC&S €66bn

                     +174                          -159                                                                                                         Portugal,
              3

                                                                                                                                                                   2%

                                                                                                                                                       USA,
                                                                                                                          Mexico,                      17%
                      -89                           +89                                                                    18%

                     (1) Parent bank.
                     (2) Ring-fenced bank.                                                                                                                                    31
                     (3) SBNA. SC USA has positive sensitivity under a -100 bp shift scenario.
Index

    1           2          3          4        5           6             7             8
Santander      Q1’22    Santander   Capital    Asset    Liquidity &   Concluding      Links,
at a Glance   Summary    Business             Quality    Funding.      Remarks      Appendix
                         Model &                          Ratings                  and Glossary
                         Strategy

                                                                                        32
Asset Quality

Credit quality remains solid…

                                                                                       Credit quality ratios

                    Q1'21                 Q4'21                  Q1'22                                                                  Q1'21                  Q4'21                Q1'22

                                                                                p 10 bps QoQ                    Cost of                                                                               0 bps QoQ
 NPL ratio          3.20%                 3.16%                   3.26%                                                                 1.08%                  0.77%                0.77%
                                                                                                                                                                                               q
                                                                                p      6 bps YoY                credit3                                                                        q      31 bps YoY

          4.08%                                                                                                                                           1.28%
  3.93%
                                                                                                                  1.18%
                   3.73%                                                                                                    1.07%                                   1.08%
                                                                                                                                       1.00% 1.00%
                                                                                                                                                                            0.94%
                                                                                                                                                                                    0.90%
                            3.32%
                                     3.21%              3.22%
                                                                                     3.26%                                                                                                    0.77%   0.77%
                                               3.20%              3.18%     3.16%

                                                                                                                                   1
   2016   2017 1   2018    2019      2020      Q1'21     Q2'21     Q3'21     Q4'21     Q1'222                      2016     2017       2018     2019      2020      Q1'21   Q2'21   Q3'21   Q4'21     Q1'22

                     (1) Acquisition of Banco Popular in 2017
                     (2) Including +19bp impact from the New Definition of Default application                                                                                                         33
                     (3) Provisions to cover losses due to impairment of loans in the last 12 months / average customer loans and advances of the last 12 months.
Asset Quality

… at the Group and country level

                   NPL ratios by country                                                                                            Cost of credit1 by country

%                         Q1 2021              Q4 2021              Q1 2022                             %                                          Q1 2021     Q4 2021   Q1 2022
    Spain                    4.98                 4.72                 4.47                                        Spain                               0.79     0.92      0.88
    UK                       1.35                 1.43                 1.42                                        UK                                  0.21     -0.09     -0.08
    Portugal                 3.84                 3.44                 3.42                                        Portugal                            0.38     0.09      0.03
    Poland                   4.82                 3.61                 3.50                                        Poland                              1.02     0.67      0.65
    US                       2.11                 2.33                 2.75                                        USA                                 2.12     0.43      0.49
    Mexico                   3.21                 2.73                 3.09                                        Mexico                              3.00     2.44      2.22
    Brazil                   4.42                 4.88                 5.68                                        Brazil                              3.79     3.73      3.94
    Chile                    4.74                 4.43                 4.70                                        Chile                               1.33     0.85      0.83
    Argentina                2.32                 3.61                 3.21                                        Argentina                           4.55     3.01      3.31
    DCB                      2.23                 2.13                 2.27                                        DCB                                 0.69     0.46      0.44

    Group                  3.20%                3.16%                3.26%                                         Group                            1.08%      0.77%     0.77%

                (1) Provisions to cover losses due to impairment of loans in the last 12 months / average customer loans and advances of the last 12 months.                      34
Index

    1           2          3          4         5          6             7             8
Santander      Q1’22    Santander   Capital    Asset    Liquidity &   Concluding      Links,
at a Glance   Summary    Business             Quality    Funding.      Remarks      Appendix
                         Model &                          Ratings                  and Glossary
                         Strategy

                                                                                        35
Liquidity and Funding

The Group’s business model combines local knowledge with global best practices
through legally, financially and operationally autonomous subsidiaries…

                                                                          Legal autonomy structure
  Dec-21

                                                                               Santander S.A.1

                                                                                   Santander
                                                                                   Consumer                   Santander
                                                                                    Finance2                   Holdings
                                                                                                                 USA
                                                                                                                                Banco
                                                   Santander                                                                  Santander
                                                   UK Group                                                                     Brasil
                                  Santander                                                                                                     Grupo
                                                    Holdings
                                    Bank                                                                                                      Financiero
                    Banco          Polska                                                                                                       Mexico          Banco
                  Santander                                                                                                                                   Santander
                 Totta SGPS,                                                                                                                                    Chile
                     SA                                                                                                                                                         Banco
                                                                                                                                                                              Santander
                                                                                                                                                                              Argentina

  Legal autonomy: There are no legal commitments that entail financial support
  Financial autonomy: Financial interconnections are limited and at market prices
  Operational autonomy: Shared services are limited and carried out through autonomous factories. Access to FMIs through other Group
     entities is very limited

                   (1) Santander Perú, Santander Uruguay and Santander Colombia do not appear on the graph due to their size. Waiting for the SRB to authorize these 3 companies to have their own
                       resolution group.                                                                                                                                                             36
                   (2) Spain Resolution Group headed by Banco Santander, S.A. Includes, among others, SCF.
Liquidity and Funding

… divided into different resolution groups that can be resolved separately
though multiple entry points

                                                                              MPE resolution strategy
   Dec-21, € bn
                                               Banking Union                                  European Union                                       3rd Countries

                                                     Spain1                                          Poland                                 Brazil                    Mexico
         Resolution Group                      PE                                              PE                                    PE                        PE

    PE   Point of Entry                             Portugal                                              UK                                Chile                    Argentina
                                               PE                                              PE                                    PE                        PE

                                                                                                                                             USA
                                                                                                                                     PE

                                                                             Size of Resolution Groups (Total assets by geography)

                                                                                                                                              155               165

                                            778                                                                                               Brazil                USA
                                                                                              410
                                                                56                                             53                          73          67                 16

                                           Spain1              Portugal                  United Kingdom        Poland                     Mexico       Chile        Argentina

We have defined the Resolution Groups (RGs) mirroring the model of autonomous financial groups so that all entities have been assigned
  to one RG
Each RG comprises the entity identified as the entry point in resolution and the entities that belong to it

                      (1) Spain Resolution Group headed by Banco Santander, S.A. Includes, among others, SCF. Banco Santander has requested the SRB that Colombia, Peru and Colombia have their own
                          Resolution Group (currently the are included in the Spain RG). Waiting for authorization.                                                                                   37
Liquidity and Funding

Santander follows an autonomous capital and liquidity model
                                                                             Capital ratios by country
                    Dec-21, %, local figures (phased-in)

                                US
                                                                                                               UK
                                 22.66
                                 20.73                                                                         21.61
                                                                                                               19.27
                                 18.84
                                                                                                               15.88
                                                                                                  Portugal
                                                                                                       29.29
                                                                                      Brazil           28.87
                                                                                                                                Poland
                                                                                      14.91
                                                                                                       26.19                    18.58
                                         Mexico                                       12.81
                                                                                                                                16.63
                                          21.56                                       11.64
                                          17.99                                                                     Santander   16.63
                                                                                                                       S.A.
                                          14.84
                                                                                                                       22.22
                                                                                                Argentina              19.18
                                                              Chile                                                               Total
                                                                                               19.39
                                                              15.86                                                    16.90       T1
                                                                                               17.03
                                                              12.22
                                                                                               16.77                              CET1
                                                               9.60

                   Note: SCF: Total Capital Ratio: 15.95%; T1: 14.51% and CET 1: 12.58%                                                   38
Liquidity and Funding

Santander’s liquidity management is based on the following principles
    Decentralized liquidity model

    Needs derived from medium- and long-term activity must be financed by medium- and long-term instruments

    High contribution from customer deposits, due to the retail nature of the balance sheet

    Diversification of wholesale funding sources by instruments/investors, markets/currencies and maturities

    Limited recourse to wholesale short-term funding

    Availability of sufficient liquidity reserves, including the discount window / standing facility in central banks to be
       used in adverse situations

    Compliance with regulatory liquidity requirements both at Group and subsidiary level, as a new conditioning
       management factor

                                                                                                                               39
Liquidity and Funding

   Stock of issuances shows diversification across instruments and entities
                                                                                Debt outstanding by type
€ bn and %, Mar-22
                                                                                                 Includes the issuance of 3 Green Bonds in line with the
                                                                                                 Group’s ESG strategy and Responsible Banking Agenda:

                                                                                                                            Product       Nom. EUR Maturity Issuance spread

                                                                                                                 Oct-19     Senior        EUR 1 bn     7        MS +65 bps

    Senior, 54.1,                                                         Senior non-                            Jun-20      SNP          EUR 1 bn     7        MS +140 bps
        30%                                                               preferred,
                                                                                                                 Jun-21      SNP          EUR 1 bn   8NC7       MS +78 bps
                                                                           52.5, 30%

                                                                                                  Banco Santander, S.A. covered bonds (cédulas hipotecarias)
                                                                                                         80.5
                                                                                                                                                      Collateralization rate:
Preference shares,                                                                                       15.7                                                 392%
                                                                                                                              50.5
     10.2, 6%
                                                                                                                               20.5
                                                                                                                                                            Max issuance
                                                                                                                o/w                   In market
                                                              Covered                                    64.8                                              capacity: €52bn
            Sub debt, 17.5,                                                                                     eligible
                                                            bonds, 41.9,                                                       30.0   Retained
                 10%                                                                                                                                   Cover pool LTV: 46%
                                                                   24%
                                                                                                   Total Cover Pool        Total issued

                      Note: preference shares also includes other AT1 instruments.                                                                                     40
Liquidity and Funding

Conservative and decentralized liquidity and funding model

            €11bn1 issued in public markets in Q1’22                                                                             Very manageable maturity profile
 € bn, Mar-22, Average exchange rates                                                                  € bn, Mar-22                                                        16.4

                                                                                                           Covered                      5.1
                                                                                                                                                       7.8
                                                                                                                                                                     5.6
                                                                                                                                                3.4           3.7
                     5.3                                                                                    Bonds
                     0.9
                                        3.9                                                                                                           13.4
                                                                                                                                                             11.2          11.3
                     1.2
                                                                                                                                                7.4
                                        0.9                                                                                             6.3
                                                                                                             Senior                                                  4.5

      1.9
                                        1.5                                                                                                                                22.4
                     3.1
      1.8                               1.5                                                                                                    10.1
                                                           0.0                 0.1                      Senior Non-                                           6.7    7.1
                                                                                                                                                       4.3
                                                                                                         Preferred                      1.8
 Covered bonds      Senior         Senior non-         Preference           Sub debt
                                                                                                                                                                           20.7
                                    preferred            shares

                                                                                                             Other                      0.1     0.7     -
                                                                                                                                                              3.7    2.5

  Other includes issuances in Brazil and Mexico
                                                                                                                                       2022    2023   2024   2025   2026   >2026

                                                                 Spain2       UK           DCB           Chile         USA             Other
                     (1) Data includes public issuances from all units with period-average exchange rates. Excludes securitisations.                                        41
                     (2) Includes Banco Santander, S.A. and Santander International Products PLC.
                     Note: preference shares also includes other AT1 instruments.
Liquidity and Funding

YTD issuances against 2022 funding plan
                                                                          Execution of 2022 funding plan
 € bn, Mar-22
                                             Hybrids                                SNP + Senior                            Covered Bonds                                         TOTAL
                                      Plan               Issued                 Plan                Issued                Plan                Issued                      Plan                   Issued
                                                                  1                                            2
 Banco Santander, S.A.              3 - 3.5                 1.8                9 - 10                    6.5                  -                      -                12 - 13.5                     8.3
 SCF                                     -                  0.0                 5-6                      1.2             0 - 0.5                     -                  5 - 6.5                     1.2
 UK                                      -                  0.0                 3-4                      1.5           0.5 - 0.75                  1.8               3.5 - 4.75                     3.3
 SHUSA                                   -                  0.0               2 - 2.5                    0.9                  -                      -                  2 - 2.5                     0.9
                                                                  1                                                2
 TOTAL                              3 - 3.5                 1.8            19 - 22.5                    10.2 0.5 - 1.25                            1.8            22.5 - 27.25                    13.8

                                     The Financial Plan is mainly focused on covering TLAC/MREL requirements to:
   Banco Santander,                            continue building up TLAC/MREL buffers.
  S.A.’s 2022 funding
  plan contemplates                            pre-finance senior non-preferred / senior preferred transactions which lose TLAC/MREL eligibility due to
     the following:                                entering in the
Liquidity and Funding

    TLAC/MREL for the Resolution Group headed by Banco Santander, S.A.
                            TLAC Mar-22(e)                                                                                          MREL Mar-22(e)

         %                                                                                  % and € bn

                                                                                                                                                       132.0
                        25.4%                                                                                 35.5%                                     14.8       Senior
                                                                                                                                           17.1%
                                                                                           Req. 29.85%2                                                            SNP
          Req. 18% +                                      10.2%                            + CBR 2.76%3
                                                                                                                                                        26.1
          CBR 3.51%                                                                                                                                      2.0       Sub debt
                                                                                                                         Req. 13.82%                    11.3       T2
                                                                                                                                                         7.9       AT1
                                              Req.
                                             6.75%

                                                                                                                                                        69.9       CET1

                       % RWA1                           % LRE1                                              % RWA1                        % LRE1        MREL
                                                                                                                                                     Instruments

Distance
                       €11bn                          €25bn                                                 €11bn                        €25bn
to M-MDA

                        Note: Figures applying the IFRS 9 transitional arrangements
                        (1) TLAC RWAs are €289.5bn and leverage exposure is €718.6bn. MREL RWAs are €372.3bn and leverage exposure is €772.4bn
                                                                                                                                                                              43
                        (2) MREL Requirement based on RWAs from Jan-24: 31.89% + Combined Buffer Requirement (CBR)
                        (3) CBR for MREL is applied to the RWAs post-MPE Add-on
Liquidity and Funding

Well-funded, diversified, prudent and highly liquid balance sheet (large %
contribution from customer deposits), reflected in solid liquidity ratios
                              Liquidity Balance Sheet
 € bn, Mar-22
                                                                                                                                    Liquidity Coverage      Net Stable Funding
                            1,341                    1,341
                                                                                                                                        Ratio (LCR)            Ratio (NSFR)
                                                                                                                                               1
                                                                                                                                      Mar-22       Dec-21      Dec-21
          Loans and                                                Customer
         advances to                                               deposits
                            1,011                      958                                                         Spain2             141%         151%         118%
          customers
                                                                                                                   UK2                176%         168%         138%
                                                                   Securitizations and others                      Portugal           138%         138%         124%
                                                        49
 Fixed assets & other          88                                  M/LT debt issuances
                                                       176
     Financial assets                                              Equity and other liabilities                    Poland             171%         197%         156%
                              241                      135
                                                        23         ST Funding
                                                                                                                   US                 142%         150%         128%
                            Assets                 Liabilities
                                                                                                                   Mexico             168%         184%         134%
                                            HQLAs3
                                                                                                                   Brazil             154%         141%         116%
 € bn, Mar-22       HQLAs Level 1                            277.1                                                 Chile              139%         148%         124%
                                                                                                                   Argentina          242%         258%         180%
                    HQLAs Level 2                             14.1
                                                                                                                   SCF                302%         319%         115%
                             o/w Level 2A                      3.8
                                                                                                                   Group              157%         163%        126%
                             o/w Level 2B                     10.2
                        Note: Liquidity balance sheet for management purposes (net of trading derivatives and interbank balances)
                        (1) Provisional data
                        (2) Spain: Parent bank, UK: Ring-fenced bank                                                                                                       44
                        (3) 12 month average, provisional data
Liquidity and Funding

      The main metrics show the strength and stability of the Group’s liquidity
      position
                           Evolution of key liquidity metrics                                        LTD and MLT funding metrics by geography
                                                                                                    Mar-22
                                                                                                                                  (Deposits + M/LT
                                                                                                                                                     1
                                                             2018     2019   2020   2021 Mar-22                       LTD Ratio   funding) / Loans
                                                                                                                  3
         1                                                                                               Spain          85%            127%
Loans / net assets                                           76%      77%    76%    75%   75%
                                                                                                         UK            111%            104%
     1
Loan-to-deposit ratio (LTD)                                  113%     114% 108% 106%      106%           Portugal       91%            117%
                                                                                                         Poland         79%            128%
Customer deposits and medium- and long-
                       1                                     114%     113% 116% 117%      117%           USA           110%            120%
term funding / loans
                                                                                                         Mexico         92%            120%
Short-term wholesale funding / net                                                                       Brazil         99%            120%
                                                              2%      3%     2%     2%    2%
liabilities                                                                                              Chile         134%             95%
                                                                                                         Argentina      55%            181%
Structural liquidity surplus / net liabilities               13%      13%    15%    16%   16%
                                                                                                         DCB           201%             75%
                                                                                                2        GROUP         106%            117%
Encumbrance                                                  25%      24%    27%    26%   26%

                               (1) Loans and advances to customers
                               (2) Latest data Dec-21                                                                                                    45
                               (3) Spain public management criteria
Liquidity and Funding

Banco Santander S.A. ratings

                                                                   Moody's                                          S&P                                  Fitch
                                                                                                                                                                   Direction
                                                                Date last          Direction                                    Direction              Date last
                                                  Rating                                             Rating Date last change                 Rating                  last
                                                                  change         last change                                   last change             change
                                                                                                                                                                   change
    Covered Bonds                                   Aa1       03/12/2019                 -             -            -               -         AAu     28/01/2022      ↑
    Senior Debt                                   (P)A2       17/04/2018                ↑             A+       16/12/2021          ↑           A      17/07/2018      ↑
    Senior Non-preferred                           Baa1       29/10/2021             Initial           A-      27/10/2021        Initial       A-     01/11/2021    Initial
    Subordinated                                 (P)Baa2 04/03/2014                     ↑            BBB+      06/04/2018          ↑          BBB     27/03/2020       ↓
    AT1                                             Ba1       20/04/2017                ↑              -            -               -         BB+     27/03/2020      ↑
    Short Term Debt                                 P-1       17/04/2018                ↑             A-1      06/04/2018          ↑          F2      17/07/2018       ↓

                    For more information on the Group’s ratings see the Links page in the Appendix                                                                             46
Liquidity and Funding

Santander Parent & Subsidiaries’ Senior Debt Ratings

                                                          Moody's                                                   S&P                                           Fitch
                                                                                                                          Direction
                                                     Date last      Direction                               Date last                                     Date last    Direction
                                        Rating                                   Outlook          Rating                    last      Outlook   Rating                              Outlook
                                                      change       last change                              change                                        change      last change
                                                                                                                          change
Group                                      A2      17/04/2018           ↑         STABLE            A+     16/12/2021        ↑        STABLE      A-     29/05/2014       ↑         STABLE
San UK PLC                                 A1      20/10/2020           ↑         STABLE             A     09/06/2015        ↑        STABLE     A+      03/01/2019       ↑         STABLE
San UK Group Holding PLC                (P)Baa1 16/09/2015               ↓        STABLE           BBB     10/04/2015        ↑        STABLE      A      20/12/2019       ↑         STABLE
Santander Consumer Finance SA              A2      17/04/2018            -        STABLE             A     16/12/2021         -       STABLE      A      28/10/2019        -        STABLE
Banco Santander Totta SA                 Baa2      08/09/2021           ↑         STABLE           BBB     18/03/2019        ↑        STABLE    BBB+     21/12/2017       ↑         STABLE
Santander Holding US                     Baa3      18/10/2016            ↓        STABLE          BBB+     06/04/2018        ↑        STABLE    BBB+     17/11/2017       ↑         STABLE
Banco Santander Mexico                   Baa1      22/04/2020            ↓        STABLE             -          -             -          -      BBB+     13/06/2012       ↓         STABLE
Banco Santander Chile                      A1      27/07/2018            ↓          NEG             A-     25/03/2021        ↓        STABLE      -           -            -           -
Santander Bank Polska                      A3      03/06/2019           ↑         STABLE             -          -             -          -      BBB+     02/06/2014       ↑         STABLE
Banco Santander Brasil                    Ba1      25/02/2016            ↓        STABLE            BB-    12/01/2018        ↓        STABLE      -           -            -

Kingdom of Spain*                        Baa1      18/09/2020           ↑         STABLE            Au     20/09/2019        ↑        STABLE      A-     19/01/2018       ↑         STABLE

                         Note: Santander México decided to withdraw the S&P ratings
                         For more information on the Group’s ratings see the Links page in the Appendix                                                                                    47
Index

    1           2          3          4         5          6             7             8
Santander      Q1’22    Santander   Capital    Asset    Liquidity &   Concluding      Links,
at a Glance   Summary    Business             Quality    Funding.      Remarks      Appendix
                         Model &                          Ratings                  and Glossary
                         Strategy

                                                                                        48
Concluding Remarks

Concluding Remarks

    The Group’s stable capital generation has been supported by strong pre-provision profits providing Santander with a
       high capacity to absorb provisions

    Strong capital levels in line with Santander’s business model based on geographic diversification, solid market
       positions in areas where it operates and independent subsidiary model in terms of capital and liquidity

    The Group is well above the regulatory capital requirement with significant payment capacity from available
       distributable items, while maintaining comfortable margins to conversion and MDA triggers

    According to March 2022 data, the Santander S.A. Resolution Group complies with the MREL and subordination
       requirements, TLAC and Group capital buffers

    Comfortable liquidity position reinforced further: compliance with regulatory liquidity requirements established at
       Group and subsidiary levels ahead of schedule, with high availability of liquidity reserves

                                                                                                                           49
Index

    1           2          3          4         5          6             7             8
Santander      Q1’22    Santander   Capital    Asset    Liquidity &   Concluding      Links,
at a Glance   Summary    Business             Quality    Funding.      Remarks      Appendix
                         Model &                          Ratings                  and Glossary
                         Strategy

                                                                                        50
Links, Appendix and Glossary

Links to Grupo Santander public materials
For additional information on the Group, please click on the images, icons or flags below

                                               Q1’22 financial results                                             Other information
    Financial report                    Earnings presentation           Series        Shareholders report      2021 Digital Annual review
                                                                        (Excel)             (interactive)

                                                                                                                  2021 Annual report

       Country presentations                          Press release               Institutional
                                                                                  Presentation

                                   UK
                                                                                                     Ratings
                                           Poland
       USA
                         Portugal
                                                        CEO video                      Pilar 3
             Mexico                Spain                (3 minutes)                                             Overview of our Corporate
                       Brazil
                                            Digital
                                           Consumer
                                                                                                                Governance presentation
                                             Bank
               Chile
                       Argentina

                                                                                                                                       51
                                                      www.santander.com         Follow us on
Links, Appendix and Glossary
                                                                                           EUROPE
                                                                               'Accelerating our business transformation in One Europe to achieve
                                                                                     superior growth with a more efficient operating model'

            Q1’22 Highlights
                                                                                                Strategic priorities
Branches                                                   3,217

Employees                                                60,943
                                                                                ▪ Grow our business by better serving our customers through regional
Total customers (mn)                                         46.1                     simplification and an improved value proposition

Digital customers (mn)                                       16.6
                                                                                ▪ Redefining customer interaction, enhancing our digital capabilities to offer
Customer loans (€ bn)                                         584                     comprehensive experiences (such as OneApp)
Customer funds (€ bn)                                         706

Underlying attributable profit (€ mn)                      1,018                ▪ Create a common operating model that embeds technology into our business,
                                                                                      leveraging our scale in the region
RoTE¹                                                     13.5%

                        (1) Adjusted RoTE: adjusted based on Group’s deployed capital calculated as contribution of RWAs at 12%. Using tangible equity, RoTE is 9.7%   52
                        Customer loans: gross loans excluding reverse repos. Customer funds: customer deposits excluding repos + marketed mutual funds
                        More information at https://www.santander.com/en/about-us/where-we-are/europe
Links, Appendix and Glossary
                                                                                          NORTH AMERICA

                                                                                            'We provide a full range of financial services with particular
                                                                                                 focus on Retail, Private and Corporate Banking'

            Q1’22 Highlights
                                                                                               Strategic priorities
Branches                                                  1,859

Employees                                              43,874                  ▪ Strengthen One Santander in North America by unifying a common and regional
                                                                                     approach to forge future growth within the region
Total customers (mn)                                        25.1
                                                                               ▪ Boost customer attraction and retention, while broadening our tailored products
Digital customers (mn)                                        6.9
                                                                                     and services proposition for a more straightforward customer experience
Customer loans (€ bn)                                        141
                                                                               ▪ Leverage our regional capabilities and sharing best practices to optimize expenses
Customer funds (€ bn)                                        146
                                                                                     and improve profitability
Underlying attributable profit (€ mn)                        806
                                                                               ▪ Support the development of inclusive and sustainable societies by offering ESG
RoTE¹                                                   24.5%                        oriented products

                       (1) Adjusted RoTE: adjusted based on Group’s deployed capital calculated as contribution of RWAs at 12%. Using tangible equity, RoTE is 12.5%   53
                       Customer loans: gross loans excluding reverse repos. Customer funds: customer deposits excluding repos + marketed mutual funds
                       More information at https://www.santander.com/en/about-us/where-we-are/north-america
Links, Appendix and Glossary
                                                                                          SOUTH AMERICA

                                                                                               'We remain focused on expanding, sharing best practices
                                                                                                 from each country and delivering profitable growth'

            Q1’22 Highlights
                                                                                               Strategic priorities
Branches                                                  4,451
                                                                               ▪ Strengthen connectivity and share best practices across countries, capturing new
Employees                                               75,784                       business opportunities
Total customers (mn)                                        64.4
                                                                               ▪ Focus on delivering profitable growth, increasing loyalty and customer attraction,
Digital customers (mn)                                      24.9                     as well as controlling risks and costs

Customer loans (€ bn)                                        149               ▪ Make headway in the development of joint initiatives between SCIB and corporates
Customer funds (€ bn)                                        184               ▪ In payment methods, focus on e-commerce strategies and on the business of
                                                                                     instant domestic and international transfers
Underlying attributable profit (€ mn)                        900
                                                                               ▪ Continue to promote inclusive and sustainable businesses, such as micro-credit
RoTE¹                                                    26.7%                       programmes, and further developed ESG initiatives

                       (1) Adjusted RoTE: adjusted based on Group’s deployed capital calculated as contribution of RWAs at 12%. Using tangible equity, RoTE is 19.8%   54
                       Customer loans: gross loans excluding reverse repos. Customer funds: customer deposits excluding repos + marketed mutual funds
                       More information at https://www.santander.com/en/about-us/where-we-are/south-america
Links, Appendix and Glossary
                                                                                           Digital Consumer Bank
                                                                                              'Europe’s consumer finance leader: solid business model,
                                                                                               geographic diversification and leading market shares in
                                                                                             auto/mobility finance and in personal finance/e-commerce'

            Q1’22 Highlights
                                                                                                Strategic priorities
Branches                                                     371
                                                                                ▪ To become the largest digital consumer bank leveraging SCF's footprint, profiting from
Employees                                               15,856                        Openbank's technology and reinforcing our leadership with strategic alliances
Active customers (mn)                                       19.2                ▪ Auto: strengthening auto financing leadership by reinforcing mobility solutions with
                                                                                      focus on leasing and subscription
Points of sale (k)                                         >130
                                                                                ▪ Consumer (non-auto): gaining market share in consumer lending, with focus on
Customer loans (€ bn)                                        117                      e-commerce checkout lending and buy now, pay later (BNPL)
Customer funds (€ bn)                                          59               ▪ Simplification for efficiency: maintaining high speed digitalization in order to
Underlying attributable profit (€ mn)                        282
                                                                                      transform the business and improve efficiency
                                                                                ▪ ESG: enhancing green finance propositions (fully electric vehicles, electric chargers,
RoTE¹                                                    12.7%
                                                                                      solar panels, etc.) in both auto and consumer loans

                        (1) Adjusted RoTE: adjusted based on Group’s deployed capital calculated as contribution of RWAs at 12%. Using tangible equity, RoTE is 12.6%   55
                        Customer loans: gross loans excluding reverse repos. Customer funds: customer deposits excluding repos + marketed mutual funds
                        More information at https://www.santander.com/en/about-us/where-we-are/digital-consumer-bank
Appendix,
    Links, Appendix
              Links and
                    and Glossary
                        Glossary
                                                                                           Santander Corporate & Investment Banking
                                                                                                    'Santander CIB supports corporate and institutional customers,
                                                                                                 offering tailored services and value-added wholesale products suited
                                                                                                                 to their complexity and sophistication'

                   Q1’22 Highlights                                                                                                               Strategic priorities
    Total income (€ mn)                                           1,763
                                                                                     ▪ Continue the business transformation to partner with our clients as strategic advisors, strengthening our
    Collaboration revenue                                   +33% YoY                     value-added services, with an increased focus on ESG and Digital solutions

    RoTE                                                         24.8%               ▪ In Europe, our aim is to become one of the relevant European CIB players by strengthening our advisory
                                                                                         capabilities leveraging a pan-European platform to better serve our global clients' needs
    Underlying attributable profit (€ mn)                            759
                                                                                     ▪ In South America, our ambition is to become the top CIB player in most countries and products,
                                                                                         consolidating our leadership position evolving from multi-country to pan-regional
Total income breakdown by business                 Revenue YoY
                                                 growth by region
                                                                                     ▪ In the US, our aim is to up-tier our CIB franchise to compete on a level playing field. Focus on the Amherst
                                                                                         Pierpont Securities (APS) integration as a step to deliver on our growth aspirations
               Other
                                                            -4%
                                                                                                          Leaders in League Tables Q1’22                                  Recent Awards
                4%
                             Global
                          Transaction                                                    Top 3
                            Banking
 Global
                              32%
 Markets
  38%                                                      +11%                               Structured Finance                   Debt Capital Markets

                       Global Debt
                        Financing                          +17%
                           26%                                                                      Green Global                                       Source: Dealogic

                                More information at https://www.santander.com/en/about-us/where-we-are/santander-corporate---investment-banking                                           56
Links, Appendix and Glossary

                                                                                        Wealth Management & Insurance
                                                                                         ‘We strive to become the best responsible wealth and insurance manager in
                                                                                                                 Europe and the Americas'

               Q1’22 Highlights                                                                                                  Strategic priorities
Total assets under management1 (€ bn)                            401                                           ▪ Continue to build our global platform
Total fees generated as % of the Group’s total fees2                                                             o Expand and develop our product and service proposition
                                                                30%
                                                                                                                 o Deploy the best digital tools
RoTE                                                         55.3%                                             ▪ Renew or improve our top 3 position as Best Global Private Bank according to
                                                                                                                 Euromoney (clients up to $250mn)
Underlying attributable profit (€ mn)                            245
                                                                                                               ▪ Continue to be the preferred funds partner for our retail network
Total contribution to Group's   profit3   (€ mn)                 603                                             o Complete the creation of the global hubs
                                                                                                                 o Expand the One Investments model and methodologies
Total contribution to Group's profit3                   +14% YoY                                                 o Work to complete the implementation of our digital funds distribution
                                                                                                                    platforms
Private Banking customers (k)                                  >220
                                                                                                               ▪ Optimize our customer service by completing our digital proposition using
Private Banking collaboration volume                    +27% YoY
                                                                                                                 customer data
Private Banking net new money (€ bn)                              2.8                                          ▪ Manage our portfolio to extend policy life
                                                                                                               ▪ Increase customer base penetration
Santander Asset Management net sales (€ bn)                      -1.0
                                                                                  ESG transversal across our businesses: offer sustainable investment management in our private banking
Insurance Gross written premiums                          +2% YoY                 platform, expand our ESG range to help reach our commitment of €100bn AuM by 2025, work towards
                                                                                  our Net Zero commitments and create a sustainable insurance value proposition.

                            (1) Total assets marketed and/or managed. Private Banking + SAM excluding AuM of Private Banking customers managed by SAM                                           57
                            (2) Including fees generated by asset management and insurance transferred to the commercial network
                            (3) Profit after tax + net fee income generated by this business and excluding insurance one-offs in 2021. Otherwise, +7%
                             More information at https://www.santander.com/en/about-us/where-we-are/wealth-management-insurance
Links, Appendix and Glossary

                                                                                    'Innovative payments solutions for both Santander and non-Santander clients'

                      Q1’22 Highlights
PagoNxt revenue                                    €162 mn; +122%
                                                                                          We are a world leading payments fintech.
Merchant Acquiring                                                                        A one-stop shop providing payment solutions to merchants, SMEs & corporates
Santander banks with Getnet                                           6                   and consumers

Active merchants (mn)                                      1.24; +7%
                                                                                        We are accelerating commerce for merchants and their connected ecosystem of
Total payments volume (EUR bn)                           34.1; +40%                     customers and business partners, delivered through:

International Trade                                                                      ▼                        ▼                    ▼                      ▼
                                                                                          The stronghold          Connected             Cloud-native, data-    Santander
Santander banks with One Trade                                        8                   serving merchants       adjacencies to        driven, global         lineage and
                                                                                          through a digital       deliver value to      payments platforms     “road-tested”
One Trade active customers (k)                                     c. 8                   commerce                businesses and                               capabilities
                                                                                          proposition and         consumers
Ebury active customers (k)                                        >15                     unique growth
                                                                                          footprint

                                 Note: YoY changes. Revenue and TPV in constant euros                                                                                   58
                                 More information at https://www.santander.com/en/about-us/where-we-are/PagoNxt
Links, Appendix and Glossary

Santander’s Responsible Banking goals: All ESG commitments for 2021
achieved. Future commitments include decarbonization targets

                                                              2018           2019              2020       2021     Q1’22          Target

Women in senior positions                                     20%            22.7%            23.7%       26.3%                30% by 2025

Equal Pay Gap                                                 3%              2%               1.5%       1.0%                 ~0% by 2025

People financially empowered (cumulative)                                    2.0mn             4.9mn      7.5mn                10mn by 2025

                                                                                                                               120bn by 2025
Green Finance raised and facilitated (€ cumulative)                          19bn             33.8bn      65.7bn   69.3bn
                                                                                                                               220bn by 2030

Electricity from renewable sources                            43%             50%               57%        75%                 100% by 2025

New Thermal coal-related power & mining phase out (€)                                                      7bn                   0 by 2030

New Reduce emission intensity in power generation portfolio              0.23 tCO2e/MWh
                                                                                                                            0.18 tCO2e/MWh by 2025
                                                                                                                            0.11 tCO2e/MWh by 2030

New Sustainable investment (€bn AuM in sustainable funds)                                                 27bn     27bn        100bn by 2025

                                                               From…To                Cumulative target

                       Note: Q1’22 data not audited                                                                                          59
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