ETH Zürich - Replacing PSM with CO in S/4 HANA Enhancing & Simplifying Academic Information Systems - Markus Knaus, Adrian Fischer & Daniel Jung ...
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ETH Zürich – Replacing PSM with CO in S/4 HANA Enhancing & Simplifying Academic Information Systems Markus Knaus, Adrian Fischer & Daniel Jung, ETH Zürich Switzerland – Version 1.0
Agenda HERUG Replacing PSM with CO in S/4 HANA Enhancing & Simplifying Academic Information Systems refine TU Berlin, Room H0110, 15. May 2019 1300 - 1340 • ETH Zürich Markus Knaus • Initial Situation / Project Goals • Technical Setup Adrian Fischer • Challenges Markus Knaus • Structures - Z tables for PSP Research Project Data • Reserves for Academic Units • Annual Academic Achievements – AAA Daniel Jung • Conclusion / Bottom Line Markus Knaus Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 2
ETH Zürich – Ready? refine Further Information: Portrait ETH Zürich “Where the future begins” Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 3
performance. Situated in the heart of Europe, yet connected all over the world, ETH Zurich is developing sophisticated solutions to the global challenges of today and tomorrow. ETH Zürich – Where the future begins refine CHF 1.8 billion, including CHF 1.3 billion total contribution from the federal government 21 and CHF 0.5 billion third-party funding 109 Nobel Prize winners patent (including Albert Einstein applications and Wolfgang Pauli) 205 invention 2 Fields Medal winners 1 Turing Award winner 87 licences disclosures 2 Pritzker Prize winners 11th in the THE ranking 7th in the QS ranking 19th in the 407 ARWU ranking spin-offs since 1996 1 2 3 21,400 students, including 530 professors 6,090 scientific staff * 2,770 technical and administrative 4,180 staff * and also 170 doctoral students, from 120 countries apprentices * full-time equivalents (FTEs), annual average Annual Report 2018 ETH Zürich | P. 1 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 4
Prospects for the new Resource and Financial platform of ETH Zürich refine 2013 rev. OR Governance / Accountancy Striving for "Good Governance" 2007 NRM Cash Accounting Accrual Accounting Framework 2000 Autonomous 2007 2015 NRM NRS Financial Management ETH as part of federaladministration Institutional Autonomy IPSAS (Accrual Accounting) 1998 2008 2019 SAP@ETHZ ETHIS refine SAP-Technology 2015 S/4HANA Lifecycle 2004 ERP 1992 SAP R/3 1990 2000 2010 2020 NRM New Federal accounting model IPSAS International Public Sector Accounting Standards NRS New accounting standard ETHIS ETH Informations System Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 6
Objectives of the refine Project refine Kick-off Meeting 6. November 2014 refine Principle Refine wants to make the distribution of funds at ETH Zurich simpler and more transparent. To this end, the complexity of existing processes and systems is reduced. For the definition of new process and system standards, business values are just as important as ETH Zurich's proven cultural values.. Project Objectives 1. New philosophy for the financial management of ETH Zurich in order to meet the future challenges of the university market 2. Modern conception of finance and accounting: cost and profit accounting instead of cash concept 3. Needs-based increase in transparency and flexibility 4. Simplification of processes and systems 5. New SAP ERP platform for mapping the new concept 6. Further development of the proven ETHIS platform 7. Compliance with relevant regulatory requirements Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 7
Technical Setup Adrian Fischer
Systems and Databases 2015 refine 27 SA DBs is e PB r em P W - p R on PE s ie r t SA v ir t u a li o d e c uni 7 . 3 x l 2 / t a 7 . 0 P or Re l . r is e r p 1 1 nte t ion r a cle P E gr a O S A Int e e s s P r oc P SA DMS Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 9
Starting Questions refine • Strategie? (Cloud or «on-premise»?) • Method? (« All in» or Step-by-Step?) • Technology? (HANA or S/4HANA? Or both?) • Skills? (Check Availability of data center skills and experience to run high end HANA systems) • Risk? (Using new software is not always fun – setup a accurate risk management in place) • Realistic? (Finding a time slot in the project and operation for this unplanned activities) • Scope? (Changing only project or productive systems – or both?) • Money? (Do we have enough arguments to request additional money for the investment (Hardware and Software)) Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 10
Decisions refine • All in -> switch all databases to HANA at the same time • ERP, BW, PI, Gateway, SAP Enterprise Portal, Solution Manager, Sandbox Systems • Steps 1. Change all Oracle databases to HANA 2. Learn and stabilize operation and optimize some applications 3. Evaluate new opportunities • Don’t change the user interface to Fiori • Set up a clear expectation management in terms of new functions and features Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 11
Greenfield Approach for the SAP S/4 Setup refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 12
Milestones Architecture refine ETHIS Portal ETHIS Portal ETHIS Portal PI Gateway Gateway Gateway R/3 BW ERP+BW Transaktion + Analytics Analytics System System System S/4HANA BW on HANA SolMan SolMan SAP HANA Plattform Oracle DB Oracle DB HANA SAP HANA Datenbank 1998 2008 2019 2015 2018 SAP@ETH ETHIS Portal refine SAP Rel. 7.xx / Oracle 11 / HANA 1.0 HANA 2.0 (1709) RH Linux Project and productive System landscapes Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 13
Technical Implementation Virtualization, Multi Tenant refine • 4 physical servers • 11 virtual machines • 38 tenents • one virtual machine up to 6 hana tenants • zero effort to move virtual machines for maintenance • Fully integrated in the data center (Storage, Backup, Monitoring) Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 14
Some Hints refine • Check detailed hardware requirements (expensive appliance vs. tailored data center integration) • Migration to HANA is very good supported, all tools from SAP works without restrictions (ERP Core) • Compression ratio for mature applications and central instances are rather low (1:2/1:3) • Use code inspector to check custom code, all changes can be done in advance • New application (SAPGUI transactions) available (z.B. FBLxH), check delta functionality Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 15
Schedule Overview refine Dec 15 1. productive HANA system landscape (Gateway) Oct 14 Diagnosis, proof of concept (tech) Jul 15 Apr 16 Order release (HW/ Go live production licences) Feb 15 Feb 16 Start migration for Project decition S/4, ERP, BW, portal, plannin/vision PI HANA@ETH Jun 16 Oct 16 First S/4HANA HW/licences ready project system Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 16
Road to Hāna • 52 Miles, 617 Curves, 3 Hours Queasy Stomachs refine • “Divorce Highway” – Quarreling MoHonolu kule a ia B Bay Honokohau 30 Bay 36 38 Nakalele Point and blowhole • Accidents & Injuries • D. T. Fleming Beach Park ay Distractions Oneloa Bay The road around this north side Bay KAPALUA Kapalua Bay 31 32 of Maui is desolate, but very picturesque. It also has a very narrow section of road with a 15 Kaha kuloa Kahakuloa Head Napili Bay Office . Plantation • Rd 30 House sheer cliff and no guard rail before you reach Kahakuloa. KAHAKULOA NAPILI Plantation Debris Golf Not for faint-hearted. Drive at your own risk. Napili Plaza Course 340 KAHANA • Kahana Gateway Falling Lower Honoapiʼilani Road Akahele St. HONOKOWAI West Maui • Camp Maluhia 30 Airport Kahekili Beach Park Train Stop WAIHE'E Hoʻokipa Beach Park Maliko Bay 11 Recycling Center Jaws Timing • Pu'u Kekaʻa Waiehu Municipal 12 Ka'anapali is the first master- Golf Course Mama's Fishhouse HA'IKU Weather (Black Rock) Valley Isle Memorial Park Kaʼanapali Beach planned resort in the United States. The first hotel was H. A. Baldwin Park 36 Whalers Village Maui Country Club Haiku Marketplace KA'ANAPALI completed in 1963. 3 WAIEHU Baby Beach Hana H PE'AHI Hanakaoʻo Beach Park Ka'anapali Golf Course Maui County is made up 340 Kanaha Beach Park ay PA'IA Mauiʼs pineapple industry was started igh wa HUELO (Canoe Beach) Wahikuli Wayside Park Lahaina Civic Center Police & Fire Stations of the islands of Maui, Moloka'i and Lana'i. The 330 KAHULUI ll H a na H ighw Bald win in Haʼiku in 1890. 398 Fourth Marine 365 In 1878 Mauiʼs first Division Memorial Twin Falls y and Post Office county seat is in Wailuku. Kahului a Kahului The Kahului Naval AirStation A Park M ve telephone line goes KAILUA t ') Maui Arts & Harbor aui or (elev. 5,788 Pu'u Kukui the WAILUKU Airport was built in 1943. After the war it nu up between Haʼiku lip Kok oad summit of Culture Center M became the Kahului Airport. United e and Makawao. He Front Street This spot at receives more than Airlines would begin the first direct R na om Lahaina Cannery Mall Star Noodle Ha lem ahi rainfall per yea r. 32 n C ostc flights to Maui from the Mainland in 1983. 390 360 Hale Paʻi Printing Museum 400 inches of e ee u K-M o Qumanter o m eu 6) lic a Mala Ramp Lahainaluna Road ʻIao Valley rk us 187 Popital hu en ters Han rt 36 37 All the green fields you see growing throughout Central Maui Lahaina Center LAHAINA ark ai Pa e Mrch ( os a'a CRoas Deli C Picnic aC Ha Hu P s H K D G lea are sugar. They are irregated by water tate aniw ou hu e & hu s rch Mau top• uide iN Lahaina Harbor fe l k S H C f il iM M • ala H from the Hana Coast. Waikamoi lley Kep iley nu o r 350 WalM arke aui B hell S S ad KE'ANAE o' Lahaina was the original capital of i C 's G Ro Ridge Trail ea Wharf Cinema Center Va Ba uma 30 Mau arco 380 igh Ho Hawaiʼi. It was moved to Honolulu art tpla reez erv 'Iao e Te ice S wa aile u ce Haliimaile The Shops at 505 'ah M te no in 1845. A major fire in 1919 destroyed y Sta Ka The Dunes at A & B e z ta tion li'im 371 General Store ina ap most of the buildings on Front Street. u a Sugar H mah Park P Maui Lani le HALI'IMAILE iʼil ni 3 'ih Kau yside Pi Puamana Park 311 Museum hu 14 ve a H Maui Tropical Plantation 305 a m Pu'unene Sugar Mill R oA W tu ghway ol o Waiko Rd. re You can see 32 windmills above Ma'alaea. WAIKAPU MAKAWAO WAILUA igh Ku Each is 180 feet high, with blades 112 feet bo wa The only sugar mill Pukalani St. oa ay ay ele Ar wa ka PUKALANI d remaining on Maui. w iH Highw long. Together, they can power 18,700 e Ma Honoapi'ilani Hi Makawao igh Kahili Golf Course y p Ka homes. There is a second wind farm i Rodeo Grounds a na Ga lan r 365 eʻ ni H being built on ʻUlupalakua Ranch land. Pukalani Launiupoko Wayside State Park The cement building on Mokulele Country Club uka nte K Se Mokulele The rock swimming enclosure was built by e OLINDA hela Highway is a pumping station P C ab 30 DRIVING SAFETY NOTE: The stretch lau the Hawaiians to protect their children from n g a l a Polo field ur Recycling of road connecting Lahaina and Ma'alaea moving water from 'Iao Valley pi k ay - Ku i op lea hw y the sharks that are common in this area. has its share of accidents, mostly from unwise to Kihei, on down to Makena. Center Ha NAHIKU o passing. Be observant and drive carefully. Sh HaHig l Ko' l Hawai'i National Guard (Blue roof building) d Ol Leodaʼs 4 Pua'a Ka'a State The chainlink fencing draped Oma OLOWALU 14 along here is to keep rocks Pumping Station Ma'alaea Power Plant Maui Raceway Park opio Road 37 377 Wayside Park Han a Hi ghwa Haleakala Highway Popular snorkeling site across from mm 14. from rolling down onto the road Mauiʼs first airport was built at Maʼalaea y Be careful you don't get your car tires Lahaina and damaging passing cars. Kealia Fishpond 5 in 1930. It was moved to this site in 1938. Pali Trail National Wildlife stuck in the sand if you park along here. 12 Parking Ma'alaea Harbor Village When the U.S. went to war with Japan, a 360 Ukumehame Beach Maui Ocean Center Sactuary larger airport was built at its current site in - Airport Hana Ma'alaea Kahului. Cement bunkers can be seen around Enchanting KULA a Ba y Kula Highway Papalua Beach Harbor Pa'ilo The only tunnel on Maui MA'ALAEA Kealia Bird Sanctuary 310 this area.They were manned to spot approaching enemy aircraft, an event that never happened. Floral Gardens 5 When descending from the summit of Haleakala, note Waianapanapa State Park 8 Ma'alaea Bay Maʼalaea Beach signs reading USE LOW GEAR. McGregor Point Kihei Gateway Plaza Papawai Point Blackieʼs Pit Stop Kula Note: There is a $10 per (Scenic Lookout) Lighthouse Mai Poina 'Oe La'u All this dry land along the Piʼilani State Beach Maui Breeze Teez Highway is in the planning stage Lodge 10 car admission to the park. - for the Kihei High School and 6 oa d ce Hosmer Grove The Hana Cultural Center is a great - KIHEI 31 Pi'ilani Village Shopping Center a commercial center. Maui Research & Technology Park 378 te r R tran ra k En rk Note: There is no food or beverages place to learn about the history of Hana. Containing a wide assortment of ancient HANA Hana - Cultural Center Bay artifacts, youʼll be taken back in time. Hana Azeka Place II r sold within the park. C This master-planned high-tech facility has a a P ters Open Monday through Friday, itʼs also Travaasa Hana Azeka Place the Maui High Performance Computing Center, P r Halemau Trail a great place to purchase local crafts. (Hotel Hana Maui) Lipoa Center which houses one of the world's fastest computers. 7 ua Parking Kihei Road Holy Ghost 8 a dq 17 Elleair Maui Golf Club Catholic Church (1895) He Leleiwi Overlook Kukui Mall Rice Park Kula Botanical Kihei Town Center 14 Gardens 18 Kalahaku Overlook Kalama Park Cove Park W aip 19 Haleakala National Park boundry - Dolphin Plaza 37 ol Haleakala HAMOA Pi'il iR Kamaole Beach I, II, III . KEOKEA National Park d Rainbow Mall an Kamaole Shopping Ctr Red Hill Overlook i 16 (elev. 10,023') Visitor Center 36 Keokea Park Ki d Hw Keawakapu Beach oa r Haleakala High Altitude p WAILEA y hu ed Observatory Site a v (”Science City”) lu pa Mokapu-Ulua Beaches Sun Yat-Sen Un Wailea The Shops at Wailea Gateway Memorial Park Va Wailea Beach Center Polo Beach lle Wailea Blue Ka Paulea Beach Golf Course - y 20 KIPAHULU up 31 Development of Polipoli State Park Poʼolenalena Beach Wailea began in 1970. 'Ohe'o Gulch oG Haleakala National Park at Kipahulu Wailea Gold & Note: There is no food or drinks Makena Landing Emerald Courses ap Keawala'i Church (1832) Maluaka Beach ʻULUPALAKUA The road along this south side of Maui continues sold within Haleakala National Park. Palapala Ho'omau Congregational Church MAKENA Makena Golf & Tennis Clubs Tedeschi Winery past Kipahulu all the way to ʻUlupalakua. Because there is a five-mile section that is KAUPO unpaved, rental car companies donʼt like their ad Puʼu Olai cars driven through here. And because it is total d ro Makena State Park has ave Little Beach the largest undeveloped isolation out here, if you have car trouble you Unp Makena State Park white sand beach on Maui. are on your own. Drive at your own risk. (Big Beach) Restroom facilities only. 31 Molokini Note: There is no way Popular snorkel and dive to drive from Route 31 in Piʻilani H destination for dive boats. ʻUlapalakua down to Wailea. ighway Paʼako Beach This road was closed in the 1980ʼs ʼAhihi Cove to build the golf courses in Wailea. Within the ʻAhihi-Kinaʼu Underwater Preserve This road becomes unpaved, sharp This large lava area crushed lava, not leading anywhere. is the last lava flow Walking trail leading to the bay. on Maui in 1790. La Perouse Bay Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 17
Survivor Road to Hāna, Maui Hawaii refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 18
Challenges Markus Knaus
SAP @ ETH Zürich – Milestones refine SAP @ ETH Zürich 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 refine Portal Portal & BW 2.0 Applications Inbox, BW Reports 2.0, Bilingualism Portal & BW Grants Management Projectes, Cost Centres e-Dossier Fonds Profit Centres HR Workflows Procurement Requests e-Dossier Personnel Annual Academic Achievements Time Tracking Approval Workflow Creditor Lean Catalog eCitations Expenses Workflow Workflow ETH Webshop Finance Regulation Delegation Inventory Accounts Receivable Office Supplies Rights Administration Authorizations Scientific Equipment Management Integrated User Administration SAP HR PA SAP License for all ETH Employees SAP on HANA SAP S/4 HANA (Payroll) (inkl. OpenText) PI / PO PI / PO Technology SAP MM SAP SD SAP Portal SAP PM IXOS PDF/A SAP HR PA (Personaladmin) SAP BW SAP FI Rel. 4.5 Rel. 4.7 ERP 2005 Unicode Rel. 7.30 Rel. 7.40 Rel. 1709 BPC 10.1 (inkl. CO, HHM, AA) IXOS Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 20
S/4HANA Enterprise Solution @ ETH Zürich refine • SAP Finance (FI) • SAP Human Resources (HCM) incl. conversion to Business Partner, Personnel administration, payroll, integration of receivables management, organisational management, workflows new chart of accounts • SAP Logistics (MM/SD) • SAP Controlling (CO) incl. SAP Lean Catalog and billing tool cost elements, cost centres, CO value flows, • SAP Maintenance (PM) internal offsetting procedures incl. SAP Equipment • Budgeting with SAP BPC • Reporting with SAP BI embedded and optimized new architecture under S/4 HANA • SAP Project System (PS) • Numerous interfaces via Mapping of projects SAP PI (LISETH, Publica, Provis, etc.) (e.g. third-party funds, procurement), cost/revenue objects • SAP Portal • SAP Profit Center Accounting (EC) Mapping of responsibility centres refine STC 13, Donnerstag 17. Januar 2019, Version 1.0 !21
ETHIS Portal refine • Don’t change the user interface to Fiori Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 22
Responsibility Centre, Cost Centre, SAP Project and PSP refine Identification Number. It is maintained in the organisational database of ETH. Via interface SAP Project it becomes a RC in ETHIS. Header element for one Responsibility or several PSPs. Not Centre postable. A unit with finances and personnel. Basis: Identification number in the organisational PSP Element database. For temporary plans (SNF, Innosuisse, industry contract etc. Postable. Cost Centre One CC per RC. Reserve PSP (type 4 Basic budget and PSP) costs. Postable. „Buffer“ for unused or overspent budgets. Not directly postable. Revenue PSP (type 5 PSP) For minor revenues from third parties. E.g. fees, sales revenue, minor services below CHF https://www.lucidchart.com/documents/edit/db396d61-1912-4266-b6a8-346a71728d96/1 10’000. Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 23
SAP Projects and PSP Elements – Reserves and Revenues refine Academic Units: Service Units: In addition to the cost centre, each responsibility In addition to a cost centre, each responsibility centre centre receives a reserve and a revenue SAP receives a revenue SAP project. Service units must project. not form reserves. Reserve 1 cost centre: Annual basic budget or personnel and material costs for academic units, the planning granularity of the service-oriented units is significantly higher. 1 reserve SAP project: To compensate for unused or overspent cost centre and project budgets (if permitted by donors) - only academic units. 1 revenue SAP project: For the posting of small revenues from e.g. script sales or minor services. In addition, academic and service units/responsibility centres can have 0-n SAP projects. Projects are represented by non-speaking, 6-digit numbers; a prefix defines the project type (research project, investment, construction project, reserve or revenue), the 3-digit suffix identifies the PSP elements. Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 24
Neue Möglichkeiten mit PSP-Elementen refine New: Improved mapping of partial funding and cooperation projects! By bundling several PSP elements under one SAP project. Previously, this was NOT possible with funds (identification by using the same name only). You can call up reports for a complete SAP project or for a PSP element. Example: Partial financing Example: Cooperation project Employees are always employed on a cost centre. The cost centre can be discharged by the usage-related allocation to project PSP: Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 25
Z-Extension for PSP Elementes refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 26
Z-Extension for PSP Elementes refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 27
Z-Extension for PSP Elementes refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 28
One House – Two Rationalities refine Increased Higher planning flexibility granularity Financial governance distinguishes more strongly than before between service and academic units. • Academic units (departments, professorships, institutes, departmental institutions) are given an even greater degree of flexibility and autonomy. If a unit does not use up its basic budget by the end of the year, it can transfer the unused portion to the following year via a reserve. This eliminates the need to optimise for the end of the year. • Service units (service departments, staff units and extra-departmental teaching and research units) will be managed even more strongly than before according to business management criteria, such as efficiency, specific task-based budgets, higher planning granularity and multi-year investment budgeting. Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 29
Reserve as Buffer refine In academic units, the reserve serves as a buffer for unused or overspent budgets. It cannot be posted to directly. Postings to or from the reserve are made by the Finance Desk as part of the year-end closing or project completion (no application required). Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 30
Annual Academic Achievements – AAA Daniel Jung
Annual Academic Achievements – AAA refine • Embedded in SAP Portal • Annual process • In place since 2010 • More than 1100 users • Total 711 reports: 16 department, 590 professor, 105 study direction • Automatic data transfer from 5 DBs, and manual entries AAA Users • Head of organisational unit: can enter data and submit report • Administrativ Assistent with delegation: can enter data • Head of a departement: can view reports of associated organisational units Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 32
AAA Webapplication refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 33
AAA Webapplication refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 34
AAA Webapplication refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 35
AAA Webapplication refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 36
AAA Webapplication – Research refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 37
AAA Webapplication – Publications refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 38
AAA Datasources refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 39
AAA Webapplication – Data Entry refine Questions Data sources Courses Performance assessments Education Completed bachelor and master theses ! Lehrbetriebs-Datenbank Ongoing doctoral theses Completed doctoral theses Finances ! SAP Finance Fourth-party funds ✏ User entry Grants ! SAP Research Collaboration contacts ✏ User entry Research fields ✏ User entry Publications ! Research Collection Knowledge and technology Patents ! Hermes-Datenbank transfer Licences Honours and awards ✏ User entry Outside activities to be approved ! SAP Outside activities Reportable outside activities ✏ User entry Internal bodies and offices ! Organisationsdatenbank und ✏ User entry Bodies and offices External bodies and offices ✏ User entry Qualitative report ✏ User entry Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 40
AAA Webapplication – Confirmation of Head of Organisational Unit refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 41
AAA Webapplication – Return Rate of Reports refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 42
AAA Webapplication – Quality of Reports refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 43
AAA Webapplication – Timeline refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 44
Data Use refine Departement evaluations Annual Academic Achievements Courses Departement resource allocation Performance assessments Quality feedback loop to educational IT applications Education Completed bachelor and master theses Management Reporting Ongoing doctoral theses Funds balance confirmation Completed doctoral theses Grantsmanagement Finances International Knowledge Base Finance Fourth-party funds Corporate Communications Grants Industry Relations Research Collaboration contacts Webpages Research fields Rankings Publications Bibliometric analyses Knowledge and Patents Scientific reporting to Government bodies technology transfer Licences Annual Report Honours and awards Office for Faculty Affairs Outside activities to be approved Legal Office Outside activities Rector’s staff Reportable outside activities Internal bodies and offices Vice President for Research and Corporate Relations Bodies and offices External bodies and offices Vice President for Human Resources and Infrastructure Qualitative report Vice President for Finance and Controlling Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 45
Annual Academic Achievements AAA – Professorship Report refine Annual Academic Achievements Leitzahl: Description: Reporting year: 2018 Questionnaire: Professorships Print date: 24.01.2019 1 Education 1.1 Courses What courses did members of your group give in the spring and autumn semester of 2018? Dating from: 24.01.2019 Number Title Semester Type Lecturer/s Hours Number of enrolments Page 1 of 15 Full Report Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 46
Annual Academic Achievements AAA – Professorship Report – Extract refine Student no. Doctoral student Supervisor Referent type Promotion date 9920802 Supervisor 9921727 Supervisor 1.5 Completed doctoral theses What doctoral theses were completed in the calendar year of 2018 and supervised by members of your group? Dating from: 24.01.2019 Student no. Doctoral student Supervisor Referent type Promotion date 10946259 Co-examiner 15.10.2018 11913126 Supervisor 19.03.2018 12910311 Co-examiner 11.06.2018 13901947 Co-examiner 08.01.2018 7906902 Supervisor 11.06.2018 7917941 Supervisor 19.03.2018 7923923 Supervisor 11.06.2018 2 Finance 2.1 Funds What credits and debits were made to the fund of your group in the calendar year of 2018? Dating from: 24.01.2019 Fund Description Source of financing Balance per Debits Credits Balance per 01.01.2018 31.12.2018 0-10340-97 Basic financing 0-10341-97 Biomolecular Production UNIT, Basic financing Page 5 of 15 Full Report Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 47
Annual Academic Achievements AAA – Professorship Report – Extract refine ID Beneficary Project name Project status Funding institution Funding program/type of Start date End date Contract Currency contract amount 0-20326-17 Using chemically Laufend ETH Zürich ETH Grants 01.08.2017 31.07.2020 CHF programmed proximal ligands to enhance the catalytic properties of heme proteins 0-20387-17 A new generation of Laufend ETH Zürich ETH Pioneer Fellows 01.01.2018 30.06.2019 CHF industrial biocatalysts: Artificial enzymes for the stereoselective synthesis of tertiary alcohols 2-70337-16 Sponsorship LOC 2013 Laufend Unternehmen Inland Sponsoring 05.12.2013 31.03.2020 CHF / Unterfonds zu 2-70617-13 2-71523-16 HFSP Fellowship für Laufend Öffentlicher Förderer Forschungsvertrag 01.05.2016 30.04.2019 CHF Ausland 2-71982-15 Site-specific Abgeschlosse Öffentlicher Förderer Forschungsvertrag 01.04.2015 31.03.2018 CHF introduction of n Ausland N6-methyladenosine using engineered snoRNP by directed evolution; fellowship for 2-72382-11 CS Teaching Award Laufend Unternehmen Inland Schenkung 01.12.2011 30.11.2021 CHF 2-73036-16 Implementation of Abgeschlosse EU Horizons 2020 Excellent Science: MSCA 01.03.2016 28.02.2018 EUR Enzymatic Activity in a n Individual Fellowship (IF) Naïve, de novo Designed Protein Scaffold by Rational Design and Laboratory Evolution Page 7 of 15 Full Report Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 48
Annual Academic Achievements AAA – Professorship Report – Extract refine ID Beneficary Project name Project status Funding institution Funding program/type of Start date End date Contract Currency contract amount 2-73179-18 directed EVOlution in Laufend EU Horizons 2020 Excellent Science: MSCA 01.10.2018 30.09.2022 EUR DROPS Innovative Training Network (ITN) 2-73943-17 Carrier for Cure: Laufend EU Horizons 2020 Excellent Science: ERC 01.11.2017 30.04.2019 EUR tailored combination Proof of Concept (PoC) drug delivery solutions for oncology 2-73959-12 Engineered protein Abgelaufen EU FP 7 Ideas: ERC Advanced 01.03.2013 31.12.2018 EUR capsids as artificial Grant bacterial organelles 2-77125-18 Design and Directed Laufend SNF Ambizione 01.11.2018 31.10.2022 CHF Evolution of Metal-Dependent Protein Catalysts for Non-Natural Chemical Transformations 2-77218-17 Directed evolution of Laufend SNF Exzellenzbeitrag 01.01.2018 31.12.2020 CHF enzyme structure and function 3.2 Collaboration contacts What institutions did your group work together with in the calendar year of 2018? ID Country Institution P A B C D E F Contact person at the institution Contact person at ETH Zurich 3,333 US University of Washington - Seattle, WA X X Prof. Prof. 3,340 CH Eidgenössische Technische Hochschule Zürich (ETH X Profs. , Prof. Zurich) 25,356 CH Universität Basel X Prof. Prof. 25,357 CH Universität Zürich (UZH) X Prof. Prof. 12,601 LT Vilniaus universitetas (Vilnius University) X X Dr. Prof. 3,339 US University of California, Los Angeles (UCLA) X Profs. Prof. Page 8 of 15 Full Report Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 49
Annual Academic Achievements AAA – Professorship Report – Extract refine ID Country Institution P A B C D E F Contact person at the institution Contact person at ETH Zurich 3,332 FR ESPCI ParisTech (Ecole supérieure de Physique et de X X Prof. Prof. Chimie industrielles de la Ville de Paris) 25,365 NL Universiteit Utrecht (Utrecht University) X Prof. , Prof. 24,798 US Brandeis University - Waltham, MA X Prof. Prof. 24,585 US University of North Carolina at Chapel Hill X Prof. Prof. P= Private sector A= Research project B= Exchange of doctoral students C= Exchange of bachelor/master students D= Exchange of scientific staff E= Cooperation in education F= Other 3.3 Research fields In which research fields did your group work in 2018 ID Level 0 Level 1 Level 2 575 Life Sciences Biochemistry, Genetics and Molecular Biology General Biochemistry, Genetics and Molecular Biology 578 Physical Sciences Chemistry Organic Chemistry 579 Multidisciplinary Multidisciplinary Multidisciplinary Research fields - Free text The group works at the chemistry-biology interface. Our current research interests are broadly focused on mechanistic investigations of enzymes and protein cages. Research highlights over the last year include: 1) the evolution of a highly active and enantiospecific metallo-enzyme from short peptides; 2) rational engineering of a designed protein cage for siRNA delivery; 3) utilization of an expanded genetic code to capture and characterize a reactive heme-carbenoid in an artificial metalloenzyme; and 4) development of a high-throughput evolutionary strategy to alter the substrate specificity of nonribosomal peptide synthetases. 4 Publications Page 9 of 15 Full Report Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 50
Annual Academic Achievements AAA – Professorship Report – Extract refine 5.1 Patents What patents did your group apply for in the calendar year of 2018? Dating from: 21.01.2019 ID Range of Validity Number of application Title Date of Applicant application 2017-094 European Patent EP18156413.9 Preparation of tertiary alcohols, resolution of 13.02.2018 ETH Zürich tertiary alcohols and stereoselective deuteration or tritiation by retroaldolases. 2018-034 European Patent EP18187862.0 POLYPEPTIDES SELF-ASSEMBLING INTO 07.08.2018 ETH Zürich NANOPARTICLES 5.2 Licences What patent, software and other licences did your group issue to third parties in the calendar year of 2018? Dating from: 21.01.2019 No data available 6 Honours and awards What honours and awards did members of your group receive in the calendar year of 2018? No data available 7 Bodies and offices Page 12 of 15 Full Report Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 51
Fazit Markus Knaus
Conclusion / Bottom Line Markus Knaus
Project dimensions: Governance – Technical – Engineering refine Find solutions refine Governance Technical S/4HANA management “refine” new technology - Two rationales - Abolition of - Simple Finance parallel worlds Universal Journal - New reserve in accounting policy - Replacement - Simple Logistics Set framework - Budgeting of fund, - New role all funds introduction Business PSP elements Warehouse - Unification of - PI/PO SAP company codes - Business Partner - New reporting - New server In March 2016, ETH Zurich, as an „early adopter“, was one - New HANA DB of the first SAP users in Switzerland to switch completely Lay foundation to the HANA in-memory database technology - New SAP software 1709 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 54
Project dimensions: Governance – Technical – Engineering refine Find solutions refine Governance Technical S/4HANA management “refine” new technology - Two rationales - Abolition of - Simple Finance parallel worlds Universal Journal - New reserve in accounting policy Set - Replacement - Simple Logistics framework - Budgeting of fund, introduction - New role all funds PSP elements Business Warehouse - Unification of SAP company codes - PI/PO - New reporting - Business Partner - New server Lay foundation - New HANA DB - New SAP software 1709 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 55
Project dimensions: Governance – Technical – Engineering refine Find solutions refine Governance Technical S/4HANA management “refine” new technology - Two rationales - Abolition of - Simple Finance parallel worlds Universal Journal - New reserve in accounting policy Set - Replacement - Simple Logistics framework - Budgeting of fund, introduction - New role all funds PSP elements Business Warehouse - Unification of SAP company codes - PI/PO - New reporting - Business Partner - Neue - New Server server Lay - Neue - New HANA HANA DB DB foundation legen Fundament - Neue - New SAP SAP Software 1610 software 1709 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 56
Replacing PSM with CO in S/4 HANA Enhancing & Simplifying Academic Information Systems refine Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 57
Annual Academic Achievements AAA – Professorship Report refine Annual Academic Achievements Leitzahl: Description: Reporting year: 2018 Questionnaire: Professorships Print date: 24.01.2019 1 Education 1.1 Courses What courses did members of your group give in the spring and autumn semester of 2018? Dating from: 24.01.2019 Number Title Semester Type Lecturer/s Hours Number of enrolments Page 1 of 15 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 58
Annual Academic Achievements AAA – Professorship Report refine Number Title Semester Type Lecturer/s Hours Number of enrolments 529-0290-00 Organic Chemistry FS 2018 Seminar 28 8 529-0290-00 Organic Chemistry HS 2018 Seminar 28 7 529-0299-00 Organic Chemistry FS 2018 Colloquium 21 8 529-0299-00 Organic Chemistry HS 2018 Colloquium 21 7 529-0731-00 Nucleic Acids and Carbohydrates HS 2018 Lecture with exercise 42 50 529-0732-00 Proteins and Lipids FS 2018 Lecture with exercise 42 69 529-0733-01 Enzymes HS 2018 Lecture with exercise 42 72 529-0739-10 Biological Chemistry A: Technologies for Directed HS 2018 Practical / laboratory 224 1 Evolution of Enzymes course 1.2 Performance assessments What performance assessments were members of your group involved in as examiners in the calendar year of 2018? Dating from: 24.01.2019 Number Title Semester Session Form Examiner/s Number of PA Page 2 of 15 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 59
Annual Academic Achievements AAA – Professorship Report refine Number Title Semester Session Form Examiner/s Number of PA 529-0020-00S Research Project HS 2017 W18 ungraded semester 1 performance 529-0200-00S Research Project I FS 2018 S18 ungraded semester 2 performance 529-0201-00S Research Project II HS 2017 W18 ungraded semester 1 performance 529-0450-00S Semesterarbeit HS 2017 W18 ungraded semester 2 performance 529-0731-00S Nucleic Acids and Carbohydrates FS 2018 S18 session examination 11 529-0731-00S Nucleic Acids and Carbohydrates HS 2017 W18 session examination 25 529-0732-00S Proteins and Lipids FS 2018 S18 session examination 34 529-0732-00S Proteins and Lipids HS 2017 W18 session examination 2 529-0733-00S Enzymes FS 2018 S18 session examination 6 529-0733-00S Enzymes HS 2017 W18 session examination 32 551-1800-01S Master's Examination HS 2017 W18 graded semester 1 performance 551-1801-00S Research Project I FS 2018 S18 ungraded semester 1 performance 551-1801-01S Research Project II HS 2017 W18 ungraded semester 1 performance 1.3 Completed bachelor and master theses What bachelor and master theses were supervised and completed by members of your group in the calendar year of 2018? Dating from: 24.01.2019 Student no. Student Lecturer Date of decree Programme level 12917563 15.01.2018 MS Page 3 of 15 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 60
Annual Academic Achievements AAA – Professorship Report refine Student no. Student Lecturer Date of decree Programme level 12938874 29.10.2018 MS 13914387 03.09.2018 MS 13915723 04.07.2018 MS 14915292 25.07.2018 BS BS = Bachelor's programme MS = Master's programme MAS = Master of Advanced Studies / Master of Business Administration 1.4 Ongoing doctoral theses What ongoing doctoral theses did members of your group supervise in the calendar year of 2018? Dating from: 24.01.2019 Student no. Doctoral student Supervisor Referent type Promotion date 11915501 Supervisor 11946803 Supervisor 12912622 Supervisor 12947081 Co-examiner 13902887 Co-examiner 14901714 Supervisor 14909626 Supervisor 14911671 Supervisor 14946255 Supervisor 15744188 Supervisor 16900425 Co-examiner 16902058 Co-examiner 17901679 Supervisor 17901968 Supervisor 18903310 Supervisor 8923609 Co-examiner 07.01.2019 Page 4 of 15 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 61
Annual Academic Achievements AAA – Professorship Report refine Student no. Doctoral student Supervisor Referent type Promotion date 9920802 Supervisor 9921727 Supervisor 1.5 Completed doctoral theses What doctoral theses were completed in the calendar year of 2018 and supervised by members of your group? Dating from: 24.01.2019 Student no. Doctoral student Supervisor Referent type Promotion date 10946259 Co-examiner 15.10.2018 11913126 Supervisor 19.03.2018 12910311 Co-examiner 11.06.2018 13901947 Co-examiner 08.01.2018 7906902 Supervisor 11.06.2018 7917941 Supervisor 19.03.2018 7923923 Supervisor 11.06.2018 2 Finance 2.1 Funds What credits and debits were made to the fund of your group in the calendar year of 2018? Dating from: 24.01.2019 Fund Description Source of financing Balance per Debits Credits Balance per 01.01.2018 31.12.2018 0-10340-97 Basic financing 0-10341-97 Biomolecular Production UNIT, Basic financing Page 5 of 15 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 62
Annual Academic Achievements AAA – Professorship Report refine Fund Description Source of financing Balance per Debits Credits Balance per 01.01.2018 31.12.2018 0-20326-17 ETH- Supplemental financing 0-20387-17 Supplemental financing 2-70337-16 Novartis Third-party resources 2-70399-11 Forschungkonto Third-party resources 2-71523-16 HFSP Fellowship / Third-party resources 2-71982-15 HFSP-Fellowship Third-party resources 2-72382-11 CS Teaching Award Third-party resources 2-73036-16 MC_ Third-party resources 2-73179-18 MC_ Third-party resources 2-73943-17 ERC_ Third-party resources 2-73959-12 ERC_ Third-party resources 2-77125-18 SNF - Ambizione / Third-party resources 2-77218-17 Third-party resources 2-78237-05 Forschungsreserven Third-party resources 2.2 Fourth-party funds What fourth-party funds did your group receive in the calendar year of 2018? No data available 3 Research 3.1 Grants Which grants were active in your group in the calendar year of 2018? Dating from: 24.01.2019 Page 6 of 15 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 63
Annual Academic Achievements AAA – Professorship Report refine ID Beneficary Project name Project status Funding institution Funding program/type of Start date End date Contract Currency contract amount 0-20326-17 Using chemically Laufend ETH Zürich ETH Grants 01.08.2017 31.07.2020 CHF programmed proximal ligands to enhance the catalytic properties of heme proteins 0-20387-17 A new generation of Laufend ETH Zürich ETH Pioneer Fellows 01.01.2018 30.06.2019 CHF industrial biocatalysts: Artificial enzymes for the stereoselective synthesis of tertiary alcohols 2-70337-16 Sponsorship LOC 2013 Laufend Unternehmen Inland Sponsoring 05.12.2013 31.03.2020 CHF / Unterfonds zu 2-70617-13 2-71523-16 HFSP Fellowship für Laufend Öffentlicher Förderer Forschungsvertrag 01.05.2016 30.04.2019 CHF Ausland 2-71982-15 Site-specific Abgeschlosse Öffentlicher Förderer Forschungsvertrag 01.04.2015 31.03.2018 CHF introduction of n Ausland N6-methyladenosine using engineered snoRNP by directed evolution; fellowship for 2-72382-11 CS Teaching Award Laufend Unternehmen Inland Schenkung 01.12.2011 30.11.2021 CHF 2-73036-16 Implementation of Abgeschlosse EU Horizons 2020 Excellent Science: MSCA 01.03.2016 28.02.2018 EUR Enzymatic Activity in a n Individual Fellowship (IF) Naïve, de novo Designed Protein Scaffold by Rational Design and Laboratory Evolution Page 7 of 15 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 64
Annual Academic Achievements AAA – Professorship Report refine ID Beneficary Project name Project status Funding institution Funding program/type of Start date End date Contract Currency contract amount 2-73179-18 directed EVOlution in Laufend EU Horizons 2020 Excellent Science: MSCA 01.10.2018 30.09.2022 EUR DROPS Innovative Training Network (ITN) 2-73943-17 Carrier for Cure: Laufend EU Horizons 2020 Excellent Science: ERC 01.11.2017 30.04.2019 EUR tailored combination Proof of Concept (PoC) drug delivery solutions for oncology 2-73959-12 Engineered protein Abgelaufen EU FP 7 Ideas: ERC Advanced 01.03.2013 31.12.2018 EUR capsids as artificial Grant bacterial organelles 2-77125-18 Design and Directed Laufend SNF Ambizione 01.11.2018 31.10.2022 CHF Evolution of Metal-Dependent Protein Catalysts for Non-Natural Chemical Transformations 2-77218-17 Directed evolution of Laufend SNF Exzellenzbeitrag 01.01.2018 31.12.2020 CHF enzyme structure and function 3.2 Collaboration contacts What institutions did your group work together with in the calendar year of 2018? ID Country Institution P A B C D E F Contact person at the institution Contact person at ETH Zurich 3,333 US University of Washington - Seattle, WA X X Prof. Prof. 3,340 CH Eidgenössische Technische Hochschule Zürich (ETH X Profs. , Prof. Zurich) 25,356 CH Universität Basel X Prof. Prof. 25,357 CH Universität Zürich (UZH) X Prof. Prof. 12,601 LT Vilniaus universitetas (Vilnius University) X X Dr. Prof. 3,339 US University of California, Los Angeles (UCLA) X Profs. Prof. Page 8 of 15 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 65
Annual Academic Achievements AAA – Professorship Report refine ID Country Institution P A B C D E F Contact person at the institution Contact person at ETH Zurich 3,332 FR ESPCI ParisTech (Ecole supérieure de Physique et de X X Prof. Prof. Chimie industrielles de la Ville de Paris) 25,365 NL Universiteit Utrecht (Utrecht University) X Prof. , Prof. 24,798 US Brandeis University - Waltham, MA X Prof. Prof. 24,585 US University of North Carolina at Chapel Hill X Prof. Prof. P= Private sector A= Research project B= Exchange of doctoral students C= Exchange of bachelor/master students D= Exchange of scientific staff E= Cooperation in education F= Other 3.3 Research fields In which research fields did your group work in 2018 ID Level 0 Level 1 Level 2 575 Life Sciences Biochemistry, Genetics and Molecular Biology General Biochemistry, Genetics and Molecular Biology 578 Physical Sciences Chemistry Organic Chemistry 579 Multidisciplinary Multidisciplinary Multidisciplinary Research fields - Free text The group works at the chemistry-biology interface. Our current research interests are broadly focused on mechanistic investigations of enzymes and protein cages. Research highlights over the last year include: 1) the evolution of a highly active and enantiospecific metallo-enzyme from short peptides; 2) rational engineering of a designed protein cage for siRNA delivery; 3) utilization of an expanded genetic code to capture and characterize a reactive heme-carbenoid in an artificial metalloenzyme; and 4) development of a high-throughput evolutionary strategy to alter the substrate specificity of nonribosomal peptide synthetases. 4 Publications Page 9 of 15 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 66
Annual Academic Achievements AAA – Professorship Report refine What publications did members of your group release in the calendar year of 2018? Dating from: 24.01.2019 ID Author/s Title Published in Publication type 20.500.11850/ Speeding up enzyme discovery and engineering Current Opinion in Structural Biology, Volume: Review Article 240907 with ultrahigh-throughput methods. 48, 149-156. 20.500.11850/ Expanding the structural analysis capabilities on Analyst, Volume: 143, 100-105. Journal Article 224849 an Orbitrap-based mass spectrometer for large macromolecular complexes. . 20.500.11850/ Nonribosomal biosynthesis of Nature Chemistry, Volume: 10, 282-287. Journal Article 244510 backbone-modified peptides. 20.500.11850/ Diversification of Protein Cage Structure Using Journal of the American Chemical Society, Journal Article 235588 Circularly Permuted Subunits. Volume: 140, 558-561. 20.500.11850/ Substrate Sorting by a Supercharged Journal of the American Chemical Society, Journal Article 239872 Nanoreactor. Volume: 140, 860-863. 20.500.11850/ A Noncanonical Proximal Heme Ligand Affords Journal of the American Chemical Society, Journal Article 242960 an Efficient Peroxidase in a Globin Fold. Volume: 140, 1535-1543. 20.500.11850/ Modular Protein Cages for Size-Selective RNA Journal of the American Chemical Society, Journal Article 235587 Packaging in Vivo. Volume: 140, 566-569. 20.500.11850/ Stereodivergent Evolution of Artificial Enzymes Angewandte Chemie. International Edition, Journal Article 263934 for the Michael Reaction. Volume: 57, 5288-5291. 20.500.11850/ Tailoring lumazine synthase assemblies for Chemical Society Reviews, Volume: 47, Review Article 267605 bionanotechnology. 3543-3557. Page 10 of 15 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 67
Annual Academic Achievements AAA – Professorship Report refine ID Author/s Title Published in Publication type 20.500.11850/ Laboratory evolution of virus-like nucleocapsids Proceedings of the National Academy of Journal Article 268447 from nonviral protein cages. Sciences of the United States of America, Volume: 115, 5432-5437. 20.500.11850/ Directed Evolution of Protein Catalysts. Annual review of biochemistry, Volume: 87, Review Article 273021 131-157. 20.500.11850/ Engineered Metalloenzymes with Chemistry - A European Journal, Volume: 24, Journal Article 284324 Non-Canonical Coordination Environments. 11821-11830. 20.500.11850/ Capture and characterization of a reactive Nature Catalysis, Volume: 1, 578-584. Journal Article 278715 haem–carbenoid complex in an artificial metalloenzyme. 20.500.11850/ Rational Engineering of a Designed Protein Journal of the American Chemical Society, Journal Article 285531 Cage for siRNA Delivery. Volume: 140, 10439-10442. 20.500.11850/ Cell Penetration, Herbicidal Activity, and Helvetica chimica acta, Volume: 101, Journal Article 302270 in vivo Toxicity of Oligo Arginine Derivatives e1800112. and of Novel Guanidinium Rich Compounds Derived from the Biopolymer Cyanophycin. l 20.500.11850/ Influence of the Membrane Dye R18 and of Chemistry & Biodiversity, Volume: 15, Journal Article 302132 DMSO on Cell Penetration of Guanidinium-Rich e1800302. Peptides. 20.500.11850/ Evolution of a highly active and enantiospecific Science, Volume: 362, 1285-1288. Journal Article 313190 metalloenzyme from short peptides. 20.500.11850/ Enzyme encapsulation in an engineered Protein Scaffolds Book Chapter 313743 lumazine synthase protein cage. 5 Knowledge and technology transfer Page 11 of 15 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 68
Annual Academic Achievements AAA – Professorship Report refine 5.1 Patents What patents did your group apply for in the calendar year of 2018? Dating from: 21.01.2019 ID Range of Validity Number of application Title Date of Applicant application 2017-094 European Patent EP18156413.9 Preparation of tertiary alcohols, resolution of 13.02.2018 ETH Zürich tertiary alcohols and stereoselective deuteration or tritiation by retroaldolases. 2018-034 European Patent EP18187862.0 POLYPEPTIDES SELF-ASSEMBLING INTO 07.08.2018 ETH Zürich NANOPARTICLES 5.2 Licences What patent, software and other licences did your group issue to third parties in the calendar year of 2018? Dating from: 21.01.2019 No data available 6 Honours and awards What honours and awards did members of your group receive in the calendar year of 2018? No data available 7 Bodies and offices Page 12 of 15 Replacing PSM with CO in S/4 HANA – Enhancing & Simplifying Academic Information Systems Print Date 14.05.2019 69
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