DSM-5 ASD Moves Forward into the Past
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J Autism Dev Disord DOI 10.1007/s10803-013-1870-3 ORIGINAL PAPER DSM-5 ASD Moves Forward into the Past Luke Y. Tsai • Mohammad Ghaziuddin Ó Springer Science+Business Media New York 2013 Abstract The fifth edition of the diagnostic and statistical Historical Perspective manual of mental disorders (DSM-5) (APA in diagnostic and statistical manual of mental disorders, Author, Wash- Jean Itard’s Wild Boy of Aveyron—historical accounts ington, 2013) has decided to merge the subtypes of per- have shown that ‘‘autism’’ has been part of the human vasive developmental disorders into a single category of condition at least since the mid-1300s as illustrated by the autism spectrum disorder (ASD) on the assumption that famous case of Victor, the wild boy of Aveyron (see Itard they cannot be reliably differentiated from one another. 1962; Malson 1972). Victor was abandoned in the forest The purpose of this review is to analyze the basis of this for about 2 years before he was ‘‘rescued’’ and admitted to assumption by examining the comparative studies between the National Institute for Deaf Mutes in Paris at the age of Asperger’s disorder (AsD) and autistic disorder (AD), and 12 years. After several months to communicate with him between pervasive developmental disorder not otherwise and to modify his primitive behavior failed, many of the specified (PDDNOS) and AD. In all, 125 studies compared leading physicians of France declared that he was an AsD with AD. Of these, 30 studies concluded that AsD and ‘‘idiot’’ with a ‘hopeless’ prognosis (Cohen 1997). Jean AD were similar conditions while 95 studies found quan- Marc Gaspard Itard, a brilliant physician, was then asked to titative and qualitative differences between them. Like- educate him. At the end of 2 years, Victor showed major wise, 37 studies compared PDDNOS with AD. Nine of gains in socialization and self-care. He could display these concluded that PDDNOS did not differ significantly genuine affection for his caretakers and even read a few from AD while 28 reported quantitative and qualitative words. Itard worked with Victor for 5 years, but was not differences between them. Taken together, these findings able to help him attain the capacity for human speech. do not support the conceptualization of AD, AsD and Since then, many children resembling Victor have been PDDNOS as a single category of ASD. Irrespective of the described with, social and communication deficits, sensory changes proposed by the DSM-5, future research and abnormalities, and stereotypic behaviors, who would clinical practice will continue to find ways to meaningfully probably be diagnosed today as having autism. subtype the ASD. Leo Kanner’s early infantile autism—in 1943, Leo Kanner, an Austrian psychiatrist who immigrated to the Keywords DSM-5 Autism spectrum disorder Autistic United States in 1924, published his now classic paper, disorder Asperger’s disorder Pervasive developmental ‘‘Autistic Disturbance of Affect Contact,’’ which described disorder not otherwise specified a group of 11 physically normal children with a previously unrecognized disorder. He noted a number of characteristic features in these children, such as an inability to develop relationships with people, extreme aloofness, a delay in speech development, and non-communicative use of L. Y. Tsai (&) M. Ghaziuddin speech. Other features included repeated simple patterns of Department of Psychiatry, University of Michigan Medical School, 2385 Placid Way, Ann Arbor, MI 48105, USA play activities and islets of ability. He described these e-mail: lyctsai@umich.edu children as having ‘‘come into the world with innate 123
J Autism Dev Disord inability to form the usual, biologically provided affective condition was never recognized in infancy and early contact with people’’ (Kanner 1943, p. 250). childhood and that those with the syndrome had excellent, Despite the variety of individual differences that logical abstract thinking and were capable of originality appeared in the case descriptions, Kanner believed that and creativity in chosen fields. The case histories also only two features were of diagnostic significance: autistic indicated the presence of developmental delay and/or aloneness and obsessive insistence on sameness. He social and behavioral difficulties from an early age. adopted the term early infantile autism to describe this Asperger subtly changed his descriptions of his syn- disorder and called attention to the fact that its symptoms drome over the years, perhaps affected by the opinions of were already evident in infancy. other authors. In his later paper (1979) he emphasized the Hans Asperger’s Autistic Psychopathy—Hans Asperger high intelligence and special abilities in areas of logic and was also born and educated in Austria. He was trained as a abstraction, whereas, in 1944, he had specified that his pediatrician but was later appointed as the director of the syndrome could be found in people of all levels of intel- Unit for Special Education at the Children’s Hospital. In ligence, including those with mental retardation. 1944, after more than a decade of working at the hospital, Asperger’s work remained relatively unknown (though he described four boys, aged 6–11 years, in his post- referred to by Rimland 1964; Rutter 1978; Van Krevelen graduate thesis (in German), ‘‘Die ‘Autistischen Psychop- 1971; and Wing 1976a, b) in English-speaking countries athen im Kindesalter’’ (autistic psychopathy in childhood). until 1981 when Lorna Wing, a British psychiatrist, pub- However, it appears that in 1926 Dr. G. E. Ssucharewa lished an influential review of the topic and added a series (Ssucharewa and Woll 1996), a Russian neurology scien- of her own (Wing 1981). tific assistant, published the first case report (in German) of Infantile Psychosis and Childhood Schizophrenia in Pre- six boys, ages 10–13 years, with clinical features resem- DSM-III and ICD-9 Era—about two decades after Kanner bling those later described by Asperger (1944). However, (1943) and Asperger (1944) publish their cases, clinicians Asperger was not aware of her work when he published his in the United States and in Europe started reporting patients paper. with similar features (Despert 1951; Van Krevelen 1952; He noted that all his cases exhibited autistic withdrawal, Creak et al. 1961). However, controversy continued over a symptom usually seen in schizophrenic patients. Asper- the definition of the disorder because the name autism was ger was not aware of Kanner’s work and the paper pub- ill chosen. It led to confusion with Bleuler’s (1911) use of lished in 1943. Both Kanner (1943) and Asperger (1944) the same term to describe the active withdrawal from the independently used Bleuler’s (1911) earlier term ‘‘autism’’ real world to an inner, presumably fantasy world seen in to describe the core clinical feature of their disorders. But schizophrenia (as cited in Wing 1976a). This confusion led Asperger did not consider his newly discovered disorder a many clinicians to use terms such as childhood schizo- form of psychosis. In fact, he appears to have used the term phrenia, borderline psychosis, symbiotic psychosis, and ‘psychopathy’ to describe a personality disorder, consistent infantile psychosis as interchangeable diagnoses with with the meaning of the word in German, since, while Kanner’s syndrome. Each label had its definition and roots discussing the paper, he stated that the cases suffered ‘‘with in a particular view of the nature and causation of autism. the type of personality disorder presented here.’’ In an attempt to clarify the confusion, Eisenberg and According to Asperger, individuals with Autistic Psy- Kanner (1956) reduced the essential symptoms to two: chopathy usually began to speak at approximately the same extreme self-isolation and preoccupation with the preser- time as children without this disorder. A full command of vation of sameness. The peculiar abnormality of language grammar was acquired sooner or later although some was considered to be secondary to the disturbance of children showed difficulty in using pronouns correctly. human relatedness and, hence, not essential. They also However, the content of speech was usually abnormal and expanded the age at onset to the first 2 years of life. Their pedantic and consisted of lengthy disquisitions on favorite efforts, however, were sometimes taken as a license to subjects. Often a word or phrase was repeated over and ignore age at onset as a necessary diagnostic criterion or to over in a stereotyped fashion. Other features he described change the criteria altogether (Rutter 1978). For example, were impaired two-way social interaction, totally ignoring Schain and Yannet (1960) omitted preservation of same- demands of the environment, repetitive and stereotyped ness from their criteria; Creak et al. (1961) used nine play, and isolated areas of interests. Asperger observed diagnostic points to encompass all forms of childhood these children talking back at teachers, sometimes verbally psychoses, including Kanner’s (1943) infantile autism, abusing and hitting other children, and lashing out at within a single diagnosis (schizophrenic syndrome of objects. Some of them seemed to gain pleasure from their childhood); and Ornitz and Ritvo (1968) emphasized dis- actions with no regard for the feelings of others or the turbances in perception as a primary symptom that was not consequences of their actions. Asperger believed that the included by Kanner. 123
J Autism Dev Disord Rutter (1968) critically analyzed the existing empirical to professionals in the field of PDD in European countries, evidence and proposed four essential characteristics of but not in the United States. Wing (1981) suggested that infantile autism: (1) a lack of social interest and respon- Asperger’s disorder be considered as a part of the ‘‘autistic siveness; (2) impaired language, ranging from absence of continuum.’’ She believed that Asperger’s disorder could speech to peculiar speech patterns; (3) bizarre motor be a mild variant of autism. DSM-III-R adopted Wing’s behavior, ranging from rigid and limited play patterns to (1981) view of Asperger’s disorder and did not offer any more complex ritualistic and compulsive behavior; and (4) specific definition and diagnostic criteria for it. early onset, before age 30 months. These features were On the other hand, empirical data published after 1980 present in nearly all children with autism. There were many could not find any significant differences (except age at other specific features, but they were unevenly distributed. onset) between individuals with infantile autism and those Infantile Autism in ICD-9-CM and Pervasive Develop- with childhood-onset PDD. In DSM-III-R, the category mental Disorders in DSM-III, DSM-III-R—despite Kan- childhood-onset PDD was eliminated. In addition, it was ner’s (1943) and Asperger’s (1944/1991) clear elucidation found to be difficult to differentiate between atypical PDD of apparently new disorders, both Early Infantile Autism and residual infantile autism. The DSM-III-R Pervasive and Autistic Psychopathy were not included in the diag- Developmental Disorders Work Group therefore decided to nostic and statistical manual of mental disorders (DSM), take a combining (lumping) approach and to include only 2nd Edition (APA 1968). Although in DSM-II diagnostic two subcategories under PDDs: autistic disorder (roughly information for childhood schizophrenia, there were a corresponding to infantile autism) and PDD not otherwise number of symptoms similar to that being described as specified (PDDNOS). Under such a system, many cases features of Kanner’s syndrome and Asperger’s disorder with features of Asperger’s disorder or cases with disin- (e.g., autistic, atypical and withdrawn behavior’’ (p. 35), tegrative forms were diagnosed as having either an autistic they were not equivalent to the diagnostic features of disorder or a PDDNOS. Kanner’s syndrome and Asperger’s disorder. Although the concept of PDDs was retained in DSM-III- Infantile autism first appeared in DSM-III (APA 1980) R, the diagnostic criteria for autistic disorder were revised and ICD-9-CM (US Department of Health and Human considerably. The DSM-III criteria were descriptive, Services 1980). Both the diagnostic systems had similar whereas the menu like scheme of DSM-III-R criteria definitions and diagnostic criteria for infantile autism. required the presence of a minimum number of criteria in However, they differed in the way they conceptualized the each of the three cardinal areas of deficits. The revised disorder. In ICD-9-CM, infantile autism was classified as a criteria were much more concrete, observable, and opera- subtype of ‘‘psychoses with origin specific to childhood,’’ tional than those in DSM-III. The revised criteria did not whereas in DSM-III, infantile autism was viewed as a type require raters to determine subjectively whether a ‘‘perva- of pervasive developmental disorders (PDDs) (defined as a sive impairment’’ or a ‘‘gross deficit’’ was present; hence, group of severe, early developmental disorders character- clinicians no longer hesitated to use the diagnosis of ized by delays and distortions in the development of social autistic disorder in older and higher-functioning autistic skills, cognition, and communication). individuals. DSM-III-R broadened the diagnostic concept In DSM-III, the diagnosis of infantile autism required of autism from DSM-III, allowing for the gradation of that the features associated with infantile autism (i.e., social behavior seen in autistic individuals. problems, communication difficulties, and bizarre behavior) Autistic disorder and Asperger’s disorder as subtypes of be present within the first 30 months of life. An atypical DSM-IV PDDs—after the publication of DSM-III, reports form, reflecting the findings of Wing and Gould (1979), and suggested that other developmental disorders such as As- a residual state subtype, where the individual no longer met perger’s disorder (Wing 1981), Rett’s disorder (Gillberg full criteria, but did at one time, were also included in 1987), and disintegrative psychosis (Rutter 1985) should DSM-III. A childhood-onset PDD subtype was also inclu- also be considered as separate subgroups of PDDs. How- ded where symptoms appeared after 30 months but before ever, the DSM-III-R Work Group on Pervasive Develop- 12 years of age, and did not meet all the symptoms for mental Disorders did not believe there was sufficient infantile autism. Thus DSM-III covered the major areas of evidence for the taxonomic validity of the additional sub- developmental concern first described by Kanner (1943), groups of PDDs to justify the establishment of separate but allowed for later development and for a residual state. diagnostic categories, preferring instead pervasive devel- When DSM-III was published in 1980, Asperger’s dis- opmental disorder not otherwise specified (PDDNOS). This order was unknown in the English literature. Hence, DSM- decision generated the concern that further research on the III did not include Asperger’s disorder as a subtype of validity of the subtypes of PDDs would become virtually PDD. However, when DSM-III-Revised (APA 1987) impossible if these disorders were grouped together (Tsai appeared in 1987, Asperger’s work was fairly well known 1992). 123
J Autism Dev Disord DSM-IV (APA 1994) and ICD-10 (WHO 1992) diag- Committee accepts the proposed change, the discrete dis- nostic schemes continue to adopt the term pervasive orders that formerly included in PDDs (e.g. autism, As- developmental disorders and include five subcategories: (1) perger’s disorder, PDDNOS, and CDD) will be eliminated autistic disorder, (2) Rett’s disorder, (3) childhood disin- and all will be absorbed into a single category: Autism tegrative disorder, (4) Asperger’s disorder, and (5) PDD- Spectrum disorder (APA 2013). It should be pointed out NOS (including atypical autism). DSM-IV and ICD-10 also that DSM-5 ASD is based on a rather small sample size offer operational diagnostic criteria for all the subtypes of (i.e., 251 mostly children and adolescent patients from two PDDs except PDDNOS. The DSM-IV diagnostic criteria sites) field trial study (Clarke et al. 2013), and that, so far, for autistic disorder resemble those of DSM-III-R, but the no validity study of DSM-5 ASD has been done. total number of diagnostic criteria has been reduced from The aim of this paper is to examine the evidence on 16 to 12, and the required minimum number for a diagnosis which the DSM-5 decision was apparently made. After of autistic disorder also has been reduced from 8 to 6. underscoring the main points of the reviews on the the These changes were made to facilitate the use of the cri- subtypes (based on which it was apparently decided to teria by clinicians while the diagnostic validity and reli- merge them), it critically examines the studies comparing ability are maintained at a high level. (1) Asperger’s disorder with high functioning Autism; (2) The concept of PDDs in DSM-IV adopts a ‘‘splitters’’ Asperger’s disorder with low functioning Autism; and (3) approach. It supports the taxonomic validity of each sub- Autistic disorder with PDDNOS. type and aims to facilitate research in the sub-classification of these disorders. Although the DSM-IV diagnostic cri- teria for PDDs are based on a well designed multisite field Methods trial study in which 977 patients participated (Volkmar et al. 1994), it is expected that these criteria will not satisfy A comprehensive literature search, limited to English-lan- everyone and they will be revised when improved under- guage journals, was conducted to locate review studies standing and further knowledge are gained to support the published between 1994 and 2013 that examined differ- taxonomic validity of each subtypes of the newer edition of ences and/or similarities between AsD and AD. Using the DSM. keywords: autism, high-functioning autism, Asperger’s During the two decades since the publication of the disorder, Asperger’s syndrome, pervasive developmental ICD-10 (1992) and the DSM IV (1994), both clinicians and disorder, PDDNOS, PDD NOS, and autism spectrum dis- researchers, in various settings, have used the subtypes of order, the following major databases were examined: PDD to describe children and adults with a range of social PubMed, MEDLINE, PsycINFO, and ERIC. Reference and other deficits. More than 500 studies of Asperger dis- lists from relevant articles (e.g., literature reviews), and order alone (including about 150 comparative studies of recent editions of key journals (e.g., Journal of Child AsD and High Function Autism) have been published. Psychology and Psychiatry, Autism, Journal of Autism and However, the debate has continued between the ‘splitters’ Developmental Disorders, Research of Autism Spectrum and the ‘lumpers,’ with the latter maintaining that autism Disorder) were also used to identify the relevant articles. and AsD lie on a ‘‘continuum’’ with AsD at the less The literature search of the databases and reference lists impaired end. was extended to the end of February 2013. DSM-5 ASD as a single category—in 2007, the Amer- Two approaches were taken to assess the identified ican Psychiatric Association formed a Work Group on papers: (1) Review and analyze previous review papers that Neurodevelopmental Disorders to review DSM-IV PDDs focused on the comparison between AD and AsD, (2) and to develop a new definition and diagnostic criteria or to Review and analyze previous studies that compared low replace the PDDs in DSM-5. After spending nearly 2,500 h functioning AD (LFA) and AsD, and that compared AD at in-person meetings and 3,500 h on teleconferences and PDDNOS. (Swedo et al. 2012), the Work Group concluded that there was sufficient evidence to replace the term ‘‘PDDs’’ with ‘‘Autism Spectrum disorder (ASD)’’ and to subsume As- Results perger’s disorder, childhood disintegrative disorder (CDD), and PDDNOS into the overarching category of ASD. The The literature search identified nine review studies. Four proposal asserted that symptoms of these three disorders review studies concluded that there was ‘‘no difference’’ represented a continuum from mild to severe of autism, between AsD and HFA; 2 reviews concluded that AsD was rather than a simple yes or no diagnosis of a specific dis- a ‘‘distinct disorder’’; and 4 reviews concluded that it was order. The Work Group also proposed to remove Rett’s premature to exclude AsD from the proposed DSM-5 ASD disorder from DSM-50 s ASD category. The APA DSM-5 (See Table 1). Three groups of investigators (Kaland 2011; 123
J Autism Dev Disord Table 1 Review studies comparing between AD and AsD Author(s) (year) Covered Number Variables studied Conclusion period of studies reviewed Myer and Minshew 1989–2000 14 IQ, cognition, language, motor skills, TOM, creativity, false- No difference between AD (2002) belief, recognizing mental state clinical characteristics, and AsD Howlin (2003) 1989–2001 26 neuropsychological & language profiles, obstetric history and No difference between AD motor abnormalities, behavioral and psychiatric disturbance and AsD Macintosh and 1989–2003 41 IQ, cognitive profiles, language, echolalia, social cognition, No difference between AD Dissanayake (2004) social difficulty, global processing, TOM, visual-spatial and AsD skills, spatial cognition, motor function, movement pre- paration, diagnosis, comorbidities, obstetric history, genetic, epidemiology Sanders (2009) 2000–2008 16 IQ profiles, verbal ability, voice profiles, language No difference between AD development, cognitive & symptom profiles, sensory-motor and AsD & cognitive functions self-presentational display rules, social interactions, social skills & problem behaviors, social phobia, diagnosis, follow-up and outcomes Matson and Wilkins 1989–2007 22 Onset/developmental, social interaction, communication, AsD is a ‘‘distinct disorder’’ (2008) restricted or repetitive behaviors & interests, sensory-motor function, intellectual/adaptive functioning, psychopathology, general Kugler (1998) 1987–1996 18 Social skills, language, IQ profiles, cognition, diagnosis, motor AsD is a ‘‘distinct disorder’’ function Rinehart et al. (2002) 1996–2002 22 Neurocognitive, pedantic speech, neuropsychology, TOM, Premature to exclude AsD embedded figure test, the strange stories recognition of faux, from the DSM-5 ASD belief, behavior & emotion, global processing, lateralization, visual illusion, shifting attention, neuropsych profiles movement, motor impairment, genetic, epidemiology, outcome Witwer and Lecavalier 1994–2006 22 IQ profiles, neuropsychological profiles, language measures, Premature to exclude AsD (2008) pedantic speech, sensory–motor & cognitive function, from the DSM-5 ASD executive function, repetitive & stereotyped behavior and social disturbance, emotional/behavioral symptoms, depression and anxiety, anxiety & psychotic symptoms, psychiatric symptoms, early history, diagnosis, sex rates, follow-up and outcomes Kaland (2011) 1996–2010 11 Social behavior, pedantic speech, language development, IQ Premature to exclude AsD profiles, cognitive and symptom profile, cortical inhibition, from the DSM-5 ASD cortical gyrification, diagnosis Kugler 1998; Witwer and Lecavalier 2008) called for more showed ‘‘significant or near significant level of differ- studies to revise and refine the external validity of Asperger ences’’ on many clinical variables between AsD and HFA disorder. as studies finding ‘‘no difference’’ between the two The first author recently completed a comprehensive subtypes. review of this issue (Tsai 2013). The review identified Comparative studies between Asperger’s disorder and 128 publications of comparative studies of AsD and HFA Low Functioning Autism (LFA)—although a recent study (from 1995 to 2012). Based on more than 90 clinical by Charman et al. (2011) found 53 % of 81 children with variables, 94 publications concluded that there were sta- ‘‘childhood autism’’ had ‘‘intellectual disability defined by tistically significant or near significant level of quantita- an IQ \70, the long-established view was that up to 75 % tive and/or qualitative differences between AsD and AD/ of individuals with autism had intellectual disability severe HFA groups; 4 publications found both similarities and enough to cause impairment in everyday functioning differences between the two groups; and 30 publications (Volkmar et al. 2004; Tsatsanis 2005). However, few concluded with no differences between the two groups. studies have compared Asperger’s disorder with autism with Thus, the review of studies comparing AsD and HFA intellectual disability/mental retardation (low functioning showed that about three times as many studies (94 vs 30) autism, LFA). 123
J Autism Dev Disord The literature search identified 12 studies that compared Butler 1998), Social skills (Njardvik et al. 1999), prenatal, individuals with LFA to individuals with AsD. Six (Ced- perinatal, and neonatal factors (Juul-Dam et al. 2001), erlund et al. 2008; de Bruin et al. 2006; Ghanizadeh 2011; psychiatric symptoms (Kenneth et al. 2004), clinical Mori et al. 2009; Ramberg et al. 1996; Toal et al. 2010) of characteristics (Walker et al. 2004), presentation of anxiety the 12 studies combined both LFA and HFA individuals (Weisbrot et al. 2005), behavioral and emotional func- into a single ‘‘Autism’’ group. The other six studies (Bal- tioning (Pearson et al. 2006), developmental/intellectual coni et al. 2012; Larsen and Mouridsen 1997; Lotspeich changes (Takeda et al. 2007), shape mapping of the hip- et al. 2004; Nordahl et al. 2007; Schumann et al. 2004; pocampus (Dager et al. 2007), chemical metabolites in the Scott et al. 2009) had a separate LFA group, which was amygdala-hippocampus region (Endo et al. 2007), compared to the AsD group. However, four (Lotspeich magnetoencephalographic pattern of epileptiform activity et al. 2004; Nordahl et al. 2007; Scott et al. 2009; Schu- (Muñnoz-Yunta et al. 2008), characteristics of challenging mann et al. 2004) of the six studies were carried out by the behaviours (Matson and Rivet 2008), effects of intellectual same group of investigators. Nonetheless, five out of the functioning on the range of core symptoms (Matson et al. six studies (Balconi et al. 2012; Larsen and Mouridsen 2008), social skills (Wilkins and Matson 2009), adaptive 1997; Lotspeich et al. 2004; Nordahl et al. 2007; Schumann independent living skills (Matson et al. 2009a), brain et al. 2004) reported significant or near significant differ- morphometry volume (Hallahan et al. 2009), patterns of ences between LFA and AsD groups. growth in adaptive social abilities (Anderson et al. 2009), To accept that AsD lies on a ‘‘continuum’’ with AD, it social and communication behavior (Fodstad et al. 2009), would be necessary to show that AsD is similar to the stereotypies and repetitive/restrictive behaviours (Matson lower functioning end of AD as well. Overall, the number et al. 2009b), one carbon metabolism disturbances and the of studies comparing LFA to AsD is small. If there is any C677T MTHFR gene polymorphism (Pasca et al. 2009), direction one could predict with a larger number of studies, developmental milestones (Matson et al. 2010), race and it would be that LFA is quite differen from AsD. challenging behaviors (Horovitz et al. 2011), independent Comparative studies between PDDNOS and AD— measures of core PDD symptomatology (Mandy et al. although PDDNOS tends to be more commonly diagnosed 2011), parent-reported behavior problem (Snow and Le- than AD, there are very few studies on the predictive cavalier 2011), meta-analysis of stability (Rondeau et al. validity and stability of this disorder. During the last dec- 2011), language comprehension (Kjellmer et al. 2012), pre- ade, several studies have questioned the adequacy of the and perinatal risk factor (Visser et al. 2012), and preva- current PDDNOS category and the literature so far has lence of SHANK3 variants (Boccuto et al. 2013). been unable to clearly differentiate children with PDDNOS Overall, although the literature appears to suggest that from children with AD (Allen et al. 2001; Volkmar et al. PDDNOS can be separated from AD, and, therefore, does 2009; Walker et al. 2004). not seem to lie on a ‘‘continuum’’ with that disorder. More The present literature search identified 37 studies that systematic research is needed to settle the issue. Till then, compared PDDNOS with Autism/Autistic disorder. The PDDNOS (or replaced by other diagnostic term) should be total subjects included in the 37 studies were 2,506 with regarded as a separate category to facilitate ongoing PDDNOS and 3,462 with Autism/autistic disorder. Out of research. this, 9 studies (which included 470 subjects with PDDNOS and 872 subjects with Autism) concluded that there was no difference between PDDNOS and Autism groups on vari- Discussion ous clinical variables: WISC-R subtests (de Bruin et al. 2006), long-term prognosis (Mordre et al. 2012), executive To facilitate the study of diagnostic validity of psychiatric functioning (Verté et al. 2006a), cognitive profiles (Kanai disorders, Robins and Guze (1970) proposed a process that et al. 2012), utility of Children’s Communication Check- included the following phases: clinical description, labo- list(Verté et al. 2006b), birth defects (Dawson et al. 2009), ratory studies, follow-up studies, and family studies. The and copper and zinc plasma concentration and the efficacy evolution of the American Psychiatric Association’s of zinc therapy (Russo and DeVito 2011), adaptive inde- Diagnostic and Statistical Manual (DSM) has closely fol- pendent living skills (Matson et al. 2009a, b), verbal and lowed such a process. Initially the DSM was developed for adaptive skills (Allen et al. 2001). psychiatrists who were interested in describing and Twenty-eight studies (which included 2,036 subjects understanding the frequency with which mental illnesses with PDDNOS and 2,590 subjects with Autism) concluded developed in our society. In 1980, the DSM-III moved that there were some quantitative and qualitative differ- from a descriptive or conceptual approach to an opera- ences between PDDNOS and Autism groups on the fol- tionalized, criteria-defining approach to enable clinicians to lowing clinical variables: clumsiness (Ghaziuddin and make diagnoses based on whether a patient’s symptoms 123
J Autism Dev Disord matched the diagnostic criteria. The DSM-III also intended of the subtypes of ASD) will be put on hold for many years to establish a higher degree of diagnostic consistency or to come. reliability within the psychiatric community. The expec- It has been reported that the DSM-5 Neurodevelop- tation of DSM-III and subsequent DSM-III-R, DSM-IV, mental Workgroup’s rationale for subsuming Asperger’s and DSM-IV-TR (APA 2000) was that DSM based disorder into ASD was partly based on the finding by Lord research would identify the underlying etiologies of the et al. (2012) that ‘‘the best predictor of which autism disorders included in the manuals, which would allow spectrum diagnosis a person received (Asperger disorder, greater refinement of the criteria and ultimately their val- PDD-NOS, or autistic disorder) was which clinic the idation by biological measures which in turn would lead to individuals went to, rather than any characteristic of the specific treatments and even prevention or cures (Tsai individual’’ (see Happé 2011). While we agree that the 2012). However, from DSM-III to DSM-IV-TR, the pro- diagnosis of autism or Asperger’s disorder (indeed, of any gress of research has not led to the definitive identification psychiatric disorder) depends on where and by whom it is of etiologies or the validation of proven biological mea- made, this observation alone does not fully explain the sures or substrates to define mental disorders. This, by the main findings reported in our paper. way, is not unique to research in the field of autism; in fact, After an initial period of confusion, clinicians and the scientific foundation of classification of almost all researchers have learned to use the DSM-IV and ICD 10 psychiatric disorders is rather weak (see Uher and Rutter criteria of PDD/ASD and its subtypes based on the 2012). For Instance, the fact that the distinction between descriptions of Kanner and Asperger. This is reflected by the various subtypes of mood disorders is not clear, does the fact that more than 3,300 cases with AsD and more than not justify the creation of a unitary category of mood 3,700 cases with HFA/AD have been identified and spectrum disorder. If autism is a psychiatric disorder, there enrolled in the comparison studies from 1994 to 2012 (Tsai is no reason why its classification should be held to a 2013). In addition, over 2,500 subjects with PDDNOS have different standard. After all, validity and reliability alone participated in the studies cited earlier. This, in itself, should not define the rationale for classification; utility is points to the existence of the face validity of these disor- also important (Ghaziuddin 2010). As others have also ders based on DSM-IV and ICD-10 criteria. Neither the argued (Leventhal 2012; Ritvo 2012; Wing et al. 2011), lack of hard scientific evidence for the existence of a single there is a real risk that eliminating the subtypes of PDDs category of ASD nor the absence of clinical consensus for and creating a single ASD will have an impact on services combining the subgroups, seemed to have deterred the and may actually result in some patients being denied DSM-5 from reverting to the DSM-III-R’s approach to services. lump the categories together. As opposed to this, the ICD- A related issue is the use of the diagnostic criteria. In the 11, due to be published in 2015, will most likely continue absence of a biological test of autism, there is a belief that to have the subtypes of Autism, Asperger syndrome (or structured instruments and observation schedules might be social reciprocity disorder), disintegrative disorder, and sufficient. Over-reliance on these instruments can some- Rett syndrome (WHO 2012). This, we believe, would have times lead to circular arguments and clinical fallacies. In been the step forward that the DSM-5 ASD unfortunately this regard, two points are important. First, rating scales missed. cannot replace diagnostic criteria (Rutter 2011); and, sec- ond, the gold standard of clinical diagnosis of autism remains clinical (Charman and Gotham 2013). Since the publication of DSM-IV, much new knowledge References and data about PDDs have been gained. At this juncture, to Allen, D. 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