DIGITAL HEALTH WHITE PAPER - Clinical Radiology Forging the Path Toward Interoperability - RANZCR
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Volume 16 No 4 / September 2020 Quarterly publication of The Royal Australian and New Zealand College of Radiologists DIGITAL HEALTH WHITE PAPER Clinical Radiology Forging the Path Toward Interoperability Outgoing CEO How Loneliness RANZCR Also Featured Reflects on Can Make Us Standards of More Vulnerable Practice for in this edition Seven Years of Artificial Achievements to COVID-19 Intelligence
“We look after each other.” At I-MED Radiology, we have a vision: to be the most respected and trusted medical imaging specialists in the world. And at the heart of that vision is our commitment to treating our patients and work colleagues alike with compassion. If you are interested in working in a welcoming environment, with people who support you in your career, who respect individuality and diversity, then come and talk to us. You’ll be sure of a warm welcome. Contact our careers team T: +61 2 8274 1080, E: careers@i-med.com.au www.i-med.com.au/careers
Editor’s Pick 39 Obituary: Dr David Green 41 From the Faculty of Radiation Oncology RANZCR Workshops, 5 A Message from the President 23 Courses and Events 2020–2021 43 Chief Censor Update: Developments in Radiation Oncology Training 7 A Final Word from the CEO 27 RANZCR2021: Elysium Diagnostics and Therapeutics (Now and 45 Radiation Oncology Trainee Matters 8 Clinical Radiology in Future) with AI Forging the Path Toward Quality Corner: Volume Interoperability 28 Work on Training and Assessment Reform 48 Delineation in Radiation Oncology Continuing! 849 How Loneliness Can 11 Make Us Uterine Fibroid 31 Targeting Cancer: Embolisation: the More Vulnerable Improving Cancer Past, the Present, to COVID-19 Outcomes for New and the Future Zealanders 13 The College Unveils Standards of 53 New Zealand Branch News 33 From the Faculty of Practice for Artificial Clinical Radiology Intelligence Chief Censor Update: 54 New Zealand’s General Election in 2020 17 Knowledge Building at The Christie NHS Foundation 34 The College’s Training Program 2020 55 News: Special Interest Groups Trust 56 Starting Out with New Chair of the College’s 37 Chief of Professional Practice Update Medicare Provider 19 Clinical Radiology Research Committee Numbers and Compliance Activities 38 Clinical Radiology Trainee Matters 61 Mammography Quality Assurance Program If you have thoughts or comments about one Have you moved What of the stories you have read in this issue, we recently? are your want to hear from you. The submission of Log into the MyRANZCR thoughts? letters to the editor, articles and news items is portal and ensure your encouraged. Please email any submissions to contact details are up to editor@ranzcr.edu.au date at www.myranzcr.com Inside News is printed on Sovereign Silk. Sovereign Silk is produced in an ISO 14001 accredited facility ensuring all processes involved in production are of the highest environmental standards. FSC mixed Sources Chain of Custody (CoC) certification ensures fibre is sourced from certified and well managed forests. Editorial Staff All rights reserved. No part of this publication may be reproduced or copied in any form or by any means without the written permission of the publisher. Editor-In-Chief Publication of advertisements and articles submitted by external parties does not constitute Dr Allan Wycherley any endorsement by The Royal Australian and New Zealand College of Radiologists of the products or views expressed. Sub Editor Inside News Lindy Baker © 2020 The Royal Australian and New Zealand College of Radiologists® (RANZCR®)
Introduction A Message from the President Dr Lance Lawler As we enter the eighth month since the and their diligence in this exceptional and guiding the organisation out of first cases of COVID-19 were reported in year. The College’s multi-layered the shadows as an advocate for the Australia and New Zealand in February response, developed by the Taskforce radiological professions. We will miss this year, we continue to come to and detailed on our website her energy and untiring enthusiasm. terms as a medical college with the (www.ranzcr.com/our-work/coronavirus), Mark Nevin, previously the College's complexities of the public health crisis, has been directed at serving the Head of Policy and Advocacy, will first and foremost the complexities that interests of all Fellows, educational serve as interim CEO for 12 months you are experiencing as clinicians. affiliates, trainees, international medical while the Board chooses a permanent graduates and College staff. The Nowhere is this more evident than in replacement. College will continue to provide any and Victoria and I want to reiterate that all support that we can. In Mark Nevin, we have an experienced the College is acutely aware of the and qualified interim CEO whose tremendous amounts of pressure this As you would know by now, in a previous role spans both our Faculties, places on our members in Melbourne, significant development for the College, and who has a strong track record in the regional Victoria and in the wider the Chief Executive Officer, Natalia advocacy work we undertake on behalf jurisdictions of Australia and Vukolova, has resigned to start a family, of members with health authorities in New Zealand. Pressure which starts effective from 25 September 2020, after Australia and New Zealand. Mark is with your work at the forefront of the more than seven years in the role. more than capable of safely steering response from the health system with Natalia has served the College the ship while the Board completes the its effects on your personal lives, and with distinction, reorganising our process of choosing its next CEO. continues in the ongoing implications management systems, strengthening for the functioning of our health systems I would like to take this opportunity engagement with government and the under the strain of the global pandemic. to wish Natalia all the very best for membership, and helping to build our the future and to welcome Mark back We encourage you to take particular international reputation as a leading to the College, I am sure both will be care of your physical, mental, emotional medical college. She has worked for a impressive in their new roles. and social health and seek support if total of 11 years in senior roles at the you need it. A number of links to useful College, having served as Executive resources to support your health and Officer of the College’s Faculty of wellbeing are available on the College Radiation Oncology from August To access useful resources visit: website. The Australian Government’s 2009 to March 2013, at which time she digital mental health portal is also a accepted the post as the College's first www.ranzcr.com/fellows/general/ useful reference for information and female CEO. your-wellbeing guidance on how to maintain good She has made a major contribution in Head to Health: Australian mental health during the COVID-19 initiating the College's training and Government, Department of Health epidemic, as is the clinician-led assessment reforms in 2014, embodying Pandemic Kindness Movement website. www.headtohealth.gov.au potentially the most significant revision The College is continuing to navigate to the College's role in specialist The Pandemic Kindness Movement: the challenges presented under the medical education since its inception. a clinician-led initiative guidance of the COVID-19 College You might say Natalia grew with the www.aci.health.nsw.gov.au/ Taskforce and I want to thank the College, proving to be an effective covid-19/kindness Taskforce members for their leadership force for positive change in many areas Volume 16 No 4 I September 2020 5
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Introduction A Final Word from the CEO Ms Natalia Vukolova My dear colleagues and friends Many of you know and respect Mark I am grateful for the opportunities throughout the College . . . for his intelligence and impressive track I had at the College—to develop record in a key role at the College. I professionally, initiate new projects, As many of you will be aware, I am am certain he will lead the College well improve old programs and systems, leaving the College shortly to prepare while a search for a permanent CEO is make a difference. for big changes in my personal life with underway. the planned arrival of a new member The College is different today to what it into my family. It is hard for me to reflect on the was when I took over, and it's better for experiences of my seven years as it. I was just one of many who made that Planning the transition has been difficult CEO, except to say that I was blessed happen. for me and the RANZCR Board, and I with a very strong management team am grateful to all who assisted in the I am deeply grateful that the Board of who trusted me and gave me great process. The Board recognised a need Directors took a chance on me in 2013 support to achieve many things for our to have certainty and clarity around the and then supported me to transform the members. executive leadership, so as to maintain College to what we have today. the momentum the College had built The list of achievements is formidable: I am proud of my contribution to your up in recent years and steer the College creating fresh policies to ensure patient College and I'm thankful to all those through the testing times we know lie access to key treatments, advocating who worked and contributed with me. ahead. powerfully to government, reforming our exams and trainee supports, For me personally, of course, it has been strengthening member engagement, the same dilemma countless women Best regards, numerous IT improvements and, have faced countless times—balancing recently, navigating the impact of a Natalia Vukolova the twin demands of having a career and devastating pandemic. RANZCR CEO 2013–2020 having children—and trying her best to get the timing and circumstances right It is a demanding and sometimes tough @NataliaVukolova so she doesn't give up her choices in life job that commands your time and and work. energy in full measure. And the job is important because strong leadership I am pleased to say the Board and I in this organisation helps safeguard have come to an agreement that works the critical work of our medical well for both sides. I have resigned as professionals—men and women who your CEO, effective from 25 September, save lives every day and are essential to and handed over the reins to our the functioning of a modern healthcare former head of policy and advocacy, system. Mark Nevin, to take charge of the management team as interim CEO for 12 months. Volume 16 No 4 I September 2020 7
Features Clinical Radiology Forging the Path Toward Interoperability Digital health has the potential to see patients become active participants more clinical documents uploaded by transform the way health care is in their health care and enable a hospitals, pathologists or radiologists delivered in Australia. A digitally transition towards value-based care. It is since March. It appears that the focus connected health system relies on only through the careful design of a new on digital health including telehealth interoperability. That is, the ability digital workflow that we can maximise consultations during COVID-19 of different information systems to the benefits and evolve our digital lockdowns has helped fast-track the communicate and exchange data, health system. adoption of some technology. and use the information exchanged to Patients have demonstrated that they improve the care provided to patients. The time is right to advance are open to using online technology Unimpeded workflow needs to be digital health to access and receive care. Current seamless, safe and secure for patients The impacts of COVID-19 on the consumer expectations for a digitally and clinical users. For changes to be delivery of health care have been enabled and connected health truly transformational we need to find substantial—perhaps none more than ecosystem are high as empowered and value-creating solutions that realise necessitating the rise in digital health digital-savvy consumers are driving benefits for each clinician across the initiatives. This has had positive impacts change in patient care and how they care pathway, and most importantly for in some areas, while also highlighting are treated. Similarly, health providers the patients, prioritising their choices as the need for transformation in other have relied on the technology more to consumers. areas. Data released by the Australian consult with their patients, diagnose and The College has developed a digital Digital Health Agency (ADHA) in June deliver care in new ways. health white paper entitled Towards 2020 showed healthcare providers There is now unprecedented Interoperability: Clinical Radiology accelerated their use of technology opportunity to transform the healthcare Forging the Path Ahead, which is during the pandemic. More than 90 system towards new, more open and currently under review via consultation. per cent of public hospitals are now connected clinical pathways. The white paper sets out a new, more using My Health Record with 5.2 million open and connected clinical pathway to 8 Inside News
Features Despite national leadership, and an overall framework for action to guide, we lack a common shared vision between the key players, and this is holding back technology-led interoperability and realisation of our digital health objectives. The rapid uptake of telehealth during the COVID-19 pandemic has shown what can be achieved when key players work together toward a common goal. “Unimpeded workflow needs to be seamless, Importantly, interoperable the consensus terminology to use safe and secure for communications and data will bring us closer towards the fundamental principle for radiology referrals. Agreement of this as the common standard patients and clinical of truly enabled patient choice. for Australian clinical radiology terminology forms the foundation users. For changes to The College’s vision is to fully utilise for the College’s digital health available technology in the patient be truly transformational journey from clinical radiology referral, priorities. we need to find value- test performance and interpretation, to receiving the results. In building the The College has already started work on a related project to creating solutions that technological architecture to support introduce structured radiology this vision, the focus is across five reports containing templates realise benefits for strategic projects with each leveraging for components of the report each clinician across and building on existing systems. and providing support for data reconciliation with the request. These include: the care pathway, and 2. Streamlining, and improving Standardised terminology—as an 1. most importantly for the essential building block towards the quality of, referrals with electronic referrals. patients, prioritising their interoperability—to ensure consistent use of terminology in Secure electronic referrals choices as consumers.” referrals to radiology. can improve how clinical and administrative information is Multiple global and local exchanged between healthcare catalogues already exist. A providers, resulting in better The College’s digital health vision targeted project is required, delivery of care. Safeguarding supported by the Department of A foundational element of patient choice will be the most Health, ADHA and the broader interoperability is the use of important factor in implementing clinical radiology sector, to review standardised terminologies to ensure eReferral. In prioritising patient the relative merits of existing that all participants have a common choice, the College strongly catalogues, mapping against other understanding of the data provided prefers the exchange repository relevant systems and standards, (known as ‘semantic interoperability’). model for eReferral. such as the Medicare Benefits Currently there is not an agreed and Schedule (MBS) and existing common language used throughout legacy catalogues. This review the patient’s care pathway by all those would produce a Radiology contributing along the way. Referral Set which would establish continued over... Volume 16 No 4 I September 2020 9
Features “A foundational 3. A platform that allows secure access to prior medical images. 5. Leveraging artificial intelligence (AI). element of Clinicians subsequently caring The potential for AI should be interoperability is the for a patient would benefit considered when progressing considerably from having access all interoperability projects, use of standardised to prior images to complement particularly in imaging-based the clinical radiologist’s report. The specialties such as clinical terminologies to ensure infrastructure of My Health Record radiology and radiation oncology. that all participants can provide a registry of tests This fifth element will be factored performed previously which could in to streamline the reporting have a common be leveraged to a greater degree process internally. Later, in the by incorporating links to historic reporting cycle, AI may assist understanding of images, stored at the practice report interpretation by the the data provided which performed the original test. referrer, where structured reports The College believes a platform will be needed. (known as ‘semantic is needed to connect My Health In realising the College’s vision to Record with the practice’s stored interoperability’). images, while validating who advance interoperability and required standards, strategic partnerships are Currently there is should have access to sensitive required to provide the leadership patient data. not an agreed and 4. Enabling clinical decision support commitment needed to lift the technical impediments currently holding us back. common language (CDS) into the workflow. The College has identified several key stakeholders representing consumers, used throughout the Technology needs to be utilised referrers and government, and is in a way that allows clinicians to patient’s care pathway provide evidence-based care for engaging with them to ensure active collaboration in codesigning digital by all those contributing patients. Easy access to clinical guidance on the best radiology health solutions. along the way.” test for a particular patient’s presentation would enhance The consultation on the College’s decision-making at the point of digital health white paper is open care. CDS must be seamlessly until 9 October 2022. Please integrated to the referrer’s submit your feedback to the workflow, which is best done by consultation via email to incorporating it into eReferral. This fcr@ranzcr.edu.au would provide timely access for general practitioners and other referrers to clinical guidelines when they are considering what radiology test or study their patient needs. 10 Inside News
Features How Loneliness Can Make Us More Vulnerable to COVID-19 My neighbor’s elderly father died during “We are leaving these people in year—meaning you could go from a the coronavirus pandemic. The virus isolation, alone,” she said. But it’s not perfectly normal measurements of 119 wasn’t the culprit, at least not directly— just hospitalised COVID-19 patients and mm Hg to 130 mm Hg, which is already the man wasn’t infected. However, right nursing home residents who suffer from hypertension, in a mere three years. before passing away, he confided in his lack of social connection during the There are also direct links between daughter that what was killing him was current pandemic. Most of us do. We social isolation and how resistant our loneliness. Loneliness caused by the are told to socially distance ourselves, to bodies are to viruses. In one series of outbreak. limit contacts, not to hug friends. From experiments more than 300 people the perspective of the immune system Although that story happened in France, were voluntarily infected with common functioning and health in general, that’s in many countries across the planet, cold viruses (the volunteers were paid disastrous. Australia included, the elderly in nursing $800 for their participation, which could homes have found themselves on total Research shows that social isolation and explain their willingness to suffer for lockdown during the pandemic—to loneliness up the risk of early death, science). For several days after exposure protect their health, the thinking went. increase the risk of stroke and cancer, they were assessed for the symptoms of And they were not the only ones. In and even raise blood pressure—which is cold—from weighting their nose mucus hospitals, coronavirus patients spend a bad thing as COVID-19 goes, elevating to measuring virus-specific antibody hours sealed off from anyone else, the probability of complications. titers in their blood. The results showed completely alone. As one nurse told me, In one study of people in their fifties and that those volunteers who were the the healthcare workers often don’t feel sixties, being lonely predicted having most socially isolated before infection like they can connect with their patients higher blood pressure a few years had about 45 per cent higher risk of and simply be there for them—what down the road. For the most lonely developing the cold from the dose with all the safety protocols, the layers of individuals, their systolic blood pressure they’ve received. protective equipment. would hike up as much as 3.6 mm per continued over... Volume 16 No 4 I September 2020 11
Features Although in this particular study the viruses used were from the rhinovirus family, another study done back in the 1990s showed that stress really ups your risk of developing symptoms of common coronaviruses (the mild type, those that used to cause us colds for centuries). And what really counteracts stress? The answer is connection with others, kindness, even simple touch—which can lower the levels of the stress hormone, cortisol. What’s more, research shows that people who experience chronic social isolation have different expression of genes responsible for the antiviral response and for antibody production, making them more susceptible to such pathogens. Of course, this is not to say that we should just throw in the towel and connectors for local practical supports stop isolating coronavirus patients on and social activities such as video chats, To access useful resources visit: hospital wards or give up on lockdowns online book clubs or fitness groups. and social distancing. Not at all. But www.ranzcr.com/fellows/general/ In some states in the US, nursing care there are things we can do to minimise your-wellbeing facilities can now apply for funding to the feelings of loneliness. We can, for buy tablets, webcams and headphones Head to Health: Australian instance, connect with others online— for their residents—to help them re- Government, Department of Health and certain ways are better than connect with their loved ones online. others. For one, try to call instead of www.headtohealth.gov.au In New York, a new program is now texting. Research reveals, for example, being proposed that would allow The Pandemic Kindness Movement: that hearing your mother’s reassuring coronavirus survivors to visit and console a clinician-led initiative words on the phone causes a larger hospitalised COVID-19 patients. oxytocin release than does receiving www.aci.health.nsw.gov.au/ similar support through a text message. As for me and my family, we simply try covid-19/kindness Oxytocin, in turn, dampens stress and to pay more attention to each other, be may lower plasma C-reactive protein empathetic, hug each other often, find levels (although for now this is only time to talk. To make sure all of us feel based on animal studies). Researchers in connected. China, meanwhile, have recently found Marta Zaraska is a Polish-Canadian science that elevated levels of C-reactive protein journalist and author of ‘Growing Young: may predict aggravation of symptoms of How Friendship, Optimism and Kindness COVID-19. Can Help You Live to 100’ Some great initiatives to counter www.growingyoungthebook.com social isolation during the pandemic are already under way. In Australia, @mzaraska programs such the Community Activation and Social Isolation initiative in Victoria, provide a hotline and, at the same time, link people to community 12 Inside News
Features The College Unveils Standards of Practice for Artificial Intelligence The College continues to be a world • Algorithm development AI and ML, including how both can leader in the application of artificial • Information management successfully help drive even better intelligence (AI) in health care, • Algorithm deployment patient care. becoming the first professional peak • Professional standards The nine ethical principles were body in the world to launch AI Standards • Audit and governance. developed specifically to guide the: of Practice. The standards align with The scope of the AI standards is to the existing Standards of Practice for • development of standards of practice guide the development, deployment Clinical Radiology and are guided by for research in AI tools and monitoring of artificial intelligence the College’s Ethical Principles for AI in • regulation of market access for ML and machine learning in public and Medicine. and AI private radiology settings. They also • development of standards of Clinical radiology and radiation serve to guide governance bodies and practice for deployment of AI tools in oncology have always been early others involved in areas where decisions medicine adopters of new technology and AI are made external to a practice or • upskilling of medical practitioners in is no exception. Application of the hospital department that have the ML and AI, and professional standards will maximise the potential to impact on patient care in • ethical use of ML and AI in medicine. opportunities AI presents, allowing for a radiology. more efficient and accessible healthcare AI presents many opportunities for a The development of the standards system that delivers improved outcomes more efficient and accessible healthcare was led by the College’s AI Committee for patients. system. While it may be some time with extensive consultation with a until the technology is clinically The standards are intended to mitigate broad range of industry, academic, appropriate and safe for patients, it is clinical risks and ensure best clinical commercial, government stakeholders important for the College to continue care when using AI in radiology. They and other medical colleges. positioning itself as a leading player in set out what is expected across a series The launch of these landmark standards the application of AI in health care. It of domains and what specific evidence follows the release of the Ethical will also allow the College to further its would need to be shown to demonstrate Principles for Artificial Intelligence in advocacy efforts in the digital health compliance. The standards cover key Medicine last year. The ethical principles sphere. components to the application of AI and outline the most appropriate use of machine learning (ML) including: Over the past decade, Australia has invested significant funds into attempting to harness and facilitate the adoption of digital health care. Digital health provides numerous opportunities for providing better informed and quality care and improving access, particularly for those in regional and remote areas. Through our advocacy, the College aims to ensure that patients and doctors have access to all relevant healthcare information, to enhance patient safety and reduce duplication of imaging, waste and costs. Digital health strives to connect healthcare providers and clinicians across all environments to deliver a seamless experience and quality care for patients. continued over... Volume 16 No 4 I September 2020 13
What’s in Issue 4? Medical Imaging Review Article: Investigation and diagnostic imaging of suspected pulmonary embolism during pregnancy and the puerperium: A review of the literature Corresponding author: Dr Jodie Tester, c/o Department of Respiratory and Sleep Medicine, The Royal Melbourne Hospital, Parkville, Vic. 3050 Australia. Pulmonary embolism (PE) is a leading cause of maternal mortality with women at increased risk of PE during pregnancy and the early postpartum period. Clinical assessment of suspected PE during pregnancy is challenging as signs and symptoms associated with PE overlap with physiological changes of pregnancy. Clinical tests and rules commonly used to assess pre‐test probability of PE were historically not well validated in the pregnant population. The challenges of clinical assessment in the pregnant and postpartum population result in a lowered threshold for diagnostic imaging. Computed tomographic pulmonary angiography (CTPA) and nuclear medicine lung scintigraphy or ventilation/perfusion (V/Q) scans are the main types of diagnostic imaging for suspected PE. Both methods are associated with small levels of ionising radiation exposure to mother and foetus. Accuracy of the diagnostic imaging tests is paramount. Haemodynamic changes of pregnancy, including increased heart rate, increased blood volume and altered flow velocity in the pulmonary arteries, may influence the quality of imaging. This comprehensive review examines the literature and evidence for the investigation and diagnostic imaging of suspected pulmonary embolism during pregnancy with CTPA and V/Q. Clinical decision‐making tools, biomarkers and diagnostic imaging during pregnancy and postpartum will be considered with a focus on diagnostic accuracy and yield, radiation dose exposure (maternal–foetal) and protocol modifications. Current practice guideline recommendations and recent literature on diagnostic pathways are also presented. Medical Imaging Technical Article: Lipiodol hysterosalpingogram: A modified HSG technique to minimize risks associated with lipiodol use Corresponding author: Dr Jane Michele Peart, Auckland Radiology Group, PO Box 9889, Newmarket 1149, Auckland, New Zealand. Assessment of tubal patency and therapeutic tubal flushing using Lipiodol, an oil‐soluble contrast media (OSCM), has been shown to enhance fertility, resulting in increased interest in the use of Lipiodol. A modified hysterosalpingogram (HSG) technique, including a supplementary ultrasound with the contrast in situ, is recommended when using Lipiodol, taking into account both safety issues and technical challenges specific to Lipiodol. Radiation Oncology Original Article: Incidence of hippocampal metastases in non‐small‐cell lung cancer Corresponding author: Dr Sophia Ly, Department of Radiation Oncology, Princess Alexandra Hospital, 199 Ipswich Rd, Woolloongabba, Qld 4102, Australia. Objectives Patients with locally advanced non‐small‐cell lung cancer (LA‐NSCLC) develop brain metastases in 25–50% of cases during the course of their disease. Data on the incidence of metastases occurring in the hippocampus/perihippocampal zones are limited. This is important when considering hippocampal‐sparing brain radiation (HS‐BR), a method that could potentially reduce the neurocognitive impact of such treatment. The aim of this study was to assess the incidence of hippocampal/perihippocampal metastases in a cohort of patients with advanced NSCLC treated at our institution. Methods This retrospective cohort study included NSCLC patients discussed at our institutional lung cancer multidisciplinary meeting between 2000 and 2016. MRI and contrast‐enhanced CT (ceCT) brain images were reviewed to assess the incidence of hippocampal/perihippocampal metastases including metastases within the hippocampal subgranular zone and a 5 mm margin (hippocampal avoidance region) defined as per the RTOG 0933 study. Results Of 2146 patients reviewed, 357 (16.6%) had brain metastases. A total of 335 patients had available MRI/ceCT brain images for review. Thirty (9%) patients had brain metastases in the hippocampal avoidance region, 8 (2.4%) with hippocampal metastases and 22 (6.6%) with perihippocampal metastases. Univariate analyses did not show an association between developing metastases in the hippocampal avoidance region and age (P = 0.75), gender (P = 0.91) and tumour type (P = 0.298). Conclusion The incidence of metastases in the hippocampal avoidance region in our large cohort of patients was 9%. With low rates of metastases in this region, HS‐BR can be considered a feasible option in the management of patients with advanced NSCLC. Radiation Oncology Original Article: Does institutional patient accrual volume impact overall survival in patients with inoperable non‐small‐cell lung cancer receiving radical (chemo)radiation? A secondary analysis of TROG 99.05 Corresponding author: Dr Mun Yee Tan, Department of Radiation Oncology, Peter MacCallum Cancer Centre, 300-305 Grattan Street, Melbourne Vic. 3000, Australia. Introduction Increased hospital patient volume, reflecting greater experience, has been shown to be associated with improved survival for some cancers. However, there is no evidence to support the volume–outcome hypothesis for inoperable non‐small‐cell lung cancer (NSCLC) patients within the Australasian setting. We examined the relationship between overall survival (OS) and institutional patient accrual volume (IPAV) in a large prospective Australasian NSCLC database (TROG 99.05). Methods TROG 99.05 was an observational study which accrued patients from 1999 to 2007 to examine the relationship between primary lung cancer volume and survival. To be eligible for inclusion, patients had to have inoperable, biopsy‐proven NSCLC planned for radiotherapy to a minimum dose of 50Gy in 20 fractions, with or without chemotherapy. Participating institutions were de‐identified and grouped according to whether accrual was low, medium or high. OS was compared between groups and adjusted for prognostic factors using Cox regression. Results About 509 patients were accrued from 16 centres. Median potential follow‐up time was 60 months. Median survival for all groups was 20 months (95% CI 18.3–21.8 months). There were no statistically significant differences in OS with increasing patient accrual across the three groups after adjustment for prognostic factors (P = 0.84, 2 df). The hazard ratios (HR) for group accrual volumes, relative to that for high‐accrual volume, were as follows: low, 1.18; medium, 1.14. Test for trend: HR = 0.91 per group (95% CI 0.76–1.09, P = 0.31). Conclusion In the setting of a clinical trial with rigorous quality assurance, we found no evidence for an association between institutional accrual and survival. Access your College journal online If you are a member of the Royal Australian and New Zealand College of Radiologists, access JMIRO free online. - Go to www.ranzcr.edu.au - Log in using your College username and password = FREE access to all JMIRO current and digitised backfile content from volume 1, 1957!
Features “The standards are As technology continues to advance at a rapid rate, it is vital that the digital The College continues to be a thought leader in digital health and AI in intended to mitigate health solution is properly considered healthcare settings, and is committed to and implemented effectively. equipping the membership to be at the clinical risks and ensure forefront of the next frontier in medicine. The College has a clear vision for how best clinical care when Australia can harness the benefits of Work continues on profession-led implementation and workforce transition using AI in radiology. digital technologies and improve the quality of care for patients who need to support the effective implementation of AI in clinical practice. They set out what is radiology services. The College’s focus in digital health centres around five key We must continue to be pioneers in this expected across a priorities: space and work with stakeholders to series of domains and • the establishment of an eReferral help them recognise the potential and risk of AI and the integral role it could system what specific evidence • access to historic images play as digital health and interoperability projects progress. would need to be • standardised terminology • development of imaging guidelines, shown to demonstrate and If you have further questions about • the managed roll out of artificial compliance.” intelligence (AI). artificial intelligence or digital health in clinical radiology please contact Melissa Doyle, Executive Officer at the College at melissa.doyle@ranzcr.edu.au lnsid1 eR01diology Clinical Radiology Information for HEALTH CONSUMERS & HEALTH PROFESSIONALS Raises awareness of medical imaging and the role of the clinical radiologist. Written by RANZCR Fellows and other Australian and New Zealand health professionals, edited by consumer and GP contributors. ✓ Information about clinical radiology tests and procedures in plain English ✓ Additional technical information for health professionals ✓ Approximately 100 information items with new items added regularly Volume 16 No 4 I September 2020 15
Features Knowledge Building at The Christie NHS Foundation Trust The Thomas Baker Fellowship It was such an honour to have been selected as the recipient of the Thomas The Christie Proton Beam Therapy Baker Fellowship last year, providing building on a blue UK morning welcomed support for my appointment as a Clinical Fellow at The Christie NHS Foundation Trust in Manchester in the United Kingdom (UK). The Thomas Baker Fellowship awards financial support to the value of $AU20,000 to one Fellow toward their return travel and living costs for a period of up to 18 months of overseas experience, allowing a qualified radiologist or radiation oncologist to further their knowledge by studying abroad. “I was particularly interested in expanding my experience in paediatric oncology. that it would be a competitive process. expanding my experience in paediatric Though I had done Following a video interview in June oncology. Though I had done most 2019, I was offered the position and the of my radiation oncology training in a most of my radiation process of obtaining the necessary visas, centre treating paediatric cases, I felt oncology training satisfying background checks, obtaining UK medical registration and the logistics my volume of hands-on experience with paediatric patients and pathologies was in a centre treating of moving across the world would then still limited. subsequently take another four to five paediatric cases, I felt months. The majority of paediatric tumour cases across the UK is referred to my volume of hands- The Fellowship is based in The Christie The Christie PBT centre which sees, NHS Foundation Trust—the largest on average, 15 new children of less on experience with single site cancer centre in Europe and than 17 years old per month. paediatric patients and the first UK centre with an NHS funded My experience with paediatric patients Proton Beam Therapy (PBT) centre. It is very quickly increased by the sheer pathologies was still a part clinical, part research Fellowship volume of patients I was seeing along working in the PBT centre with four- their treatment pathway from clinic to limited. ” month rotations through the following discussion of their case in paediatric subsites: sarcoma, head and neck MDTs, developing and assessing their My post commenced in December 2019, tumours, paediatric body and central radiotherapy plans, and being involved but the preparation process commenced nervous system tumours, and adult in surveillance through follow up many months prior. I made a site visit central nervous system tumours. As reviews. Adapting to a new workplace, in March 2019, spent several days more indications are added to the UK’s within a new healthcare system took shadowing clinics and observing clinical Proton Beam Therapy indications list, some adjustment but in itself was an operations and arranged a face-to-face this may expand in the future. opportunity to learn of the different meeting with the Fellowship supervisor These tumour subsites aligned well ways daily work processes and structures at The Christie to demonstrate my keen with my personal subspecialty interest could be run. interest for the Fellowship post, knowing areas, and I was particularly interested in continued over... Volume 16 No 4 I September 2020 17
Features The friendly and colourful paediatric waiting room area Proton beam therapy is an area of The benefits of the Fellowship however of the UK itself with its varied beautiful interest that has developed with my extend far beyond the specifics of countryside, amazing peaks and lakes growing passion for paediatric oncology. PBT itself. It has developed in me a and towns embedded in historical With Australia now having started very detailed, almost forensic level of charm. construction on their first PBT centre at scrutiny with volume delineation, and I would encourage any Fellow or the Australian Bragg Centre for Proton allowed a systematic approach to plan trainee who has passed their Part II Therapy Adelaide, patients, particularly assessment and evaluation. I have examinations to apply for opportunities parents, will be asking all the more no doubt it has enhanced my overall overseas that align with their interest about its role in management of their or ability in technical radiotherapy which areas and to apply for the Thomas Baker their child’s tumour. will extend into my photon practice. award to support their endeavours. Given its new implementation in the The clinical experience working in UK, there is significant emphasis on proton therapy has been invaluable systematic, accurate and consistent and one which was only made possible collection of clinical outcome data, by me venturing overseas. I have been Applications for the 2021 Thomas integrated into daily clinical practice. able to learn the intricacies of working Baker Fellowship will open in This has developed my diligence with a new form of radiotherapy, with December 2020. The application in documentation and robust data its inherent differences to conventional opening date will be announced collection, and created opportunities photon therapy and how this manifests via email and on the College for progression of my PhD with projects dosimetrically as well as clinically as website: www.ranzcr.com/college/ that I have become involved with. It has patients undergo proton therapy and grants-and-awards/educational- allowed me to gain a sharper eye to in their ensuing follow up years into the fellowships recognise and record particular toxicities future. observed during treatment and beyond. It goes without saying that aside from the immense academic and clinical Dr Eunji Hwang opportunities, the social aspect of RANZCR Fellow meeting, working with and connecting Faculty of Radiation Oncology with new people while living here in the UK has been invaluable. Now almost eight months into my Fellowship post and having lived through the onset of a global pandemic, colleagues have become friends, and my husband and I have integrated into a community here in Manchester that we love. Though the pandemic has The Proton Fellows crew: Dr Simona limited our initial plans for global travel Gaito (left), Dr Shermaine Pan (middle), particularly around Europe, we have Dr Eunji Hwang (right) taken the opportunity to explore more 18 Inside News
Features New Chair of the College’s Clinical Radiology Research Committee Professor Paul Parizel Professor Paul Parizel was appointed In 2002, during the Annual Scientific like a perfect moment to consider a new as the inaugural David Hartley Chair in Meeting, held in Adelaide, I became professional and personal challenge. Radiology, based at Royal Perth Hospital an Honorary Fellow of the College And what better place to do so than (RPH), in September 2019. The chair was and served as Kodak visiting professor. in Perth, Western Australia, one of the established by the University of Western Somewhere, in the back of my mind, nicest cities on the face of this earth? Australia to improve clinical governance, I had always been thinking how nice education and research, and to develop it would be to work in Australia and How does your experience of closer ties within the medical professions share my professional experience radiology in Australia compare to and also with the wider community of with younger colleagues. There is a your experience in Belgium? WA. Born and raised in the historic city famous quote by Ralph Waldo Emerson of Antwerp, Belgium, he completed that states that “life is a journey, not First of all, I would like to say that I am his medical school education at the a destination”. To travel successfully grateful for the opportunity to share University of Antwerp before working on the journey of Life, one needs an some of my thoughts and visions with at the Antwerp University Hospital and ambitious plan, a steady compass, the readers of Inside News. undertaking Fellowships at centres and—importantly—the ability to avoid There is an expression in French that of international renown including at the doldrums and make good use of the says ‘plus ça change, plus c’est la même Massachusetts General Hospital and prevailing winds. chose’ (the more things change, the Harvard Medical School. more they stay the same). In a way this In February, Prof Parizel was appointed “Human interaction holds true for working as a radiologist as Chair of the College’s Clinical in Australia. Compared to Belgium, Radiology Research Committee (CRRC). between professionals there are many similarities in the work we do, and in the organisation and is the force that structure of radiology departments. When did you move to Australia and why? enables the transfer The technical platform at RPH is very similar to what I had in my department I arrived in Perth, WA on Sunday 22 of knowledge, and at Antwerp University Hospital. The September 2019, which happened to be patient population in a tertiary referral my birthday. I had signed my contract the development of centre is very diverse, interesting, and, more than a year earlier, but it took a very long time to get all the red tape scientific collaboration, at times, challenging. RPH is unique in that we see many patients referred sorted out. In fact, there were times and the College is an through the State Major Trauma Unit that I was not even sure if I would ever and the State Spinal and Scoliosis succeed in getting all the documents essential catalyst to Service. However, a similarity between together. drive these processes.” Australia and Belgian is the juxtaposition My reasons for coming to Australia of a public health system and a private were manifold. For more than 30 years, system, both with their specific and I have been friends with Professor Mark In Europe, I finished my terms as individual roles. Khangure, and thanks to him, I’ve had President (2017) and Chairman of the Of course, there are also some the occasion to visit Perth several times, Board (2018) of the European Society differences in the type of examinations and always was impressed by the high of Radiology (ESR), and as President of and protocols we perform, but overall I professional and ethical standards of the European Congress of Radiology would say that the similarities are far, far radiology in Australia. meeting in Vienna in 2017. It seemed greater than the differences. continued over... Volume 16 No 4 I September 2020 19
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Features What are your areas of interest importance to teach (junior) radiologists within radiology? “In my view, research is how to conduct research, how to best interface with clinicians, and how to I trained as a neuroradiologist and have an essential component use software applications to extract always been interested in imaging of the brain and spine in a variety of disease in the delivery of information from the big data sets, which are the constituent parts of all conditions. In the last 10 years, my main areas of interest have been imaging in excellent patient- cross-sectional imaging techniques. traumatic brain injury patients and the centred health care. We must provide radiology excellence implementation of quantitative imaging to the next generation, which can best and artificial intelligence techniques Radiology is moving be done through fostering research. within our field. However, as chair of the Department of Radiology at Antwerp along a trajectory from What is your vision for the CRRC University Hospital, and as supervisor an ‘art’ to a ‘science’, and research at the College? of many PhD and Master students, I always considered that it was my duty to from producing ‘pretty With the CRRC, the College has an instrument to develop and steer the keep abreast of developments in other areas of radiology as well. Our discipline images’ to quantitative present and future course of our has undergone such an amazing data sets.” discipline. In my view, our plan should be to stimulate and foster excellence in transformation in the past couple of decades. Radiology, or imaging in the Human interaction between research, and to enable the intellectual broadest sense of the term, has become professionals is the force that enables awakening of radiologists, by offering the crossroads in any modern hospital. the transfer of knowledge, and the support and encouragement. But, development of scientific collaboration, our CRRC should be much more than and the College is an essential catalyst just an instrument to select the best What motivated you to get presentations and publications, or to involved with the College? to drive these processes. award prizes and Fellowships. As stated previously, I fondly remember Why is research so important to In my view, research is an essential the 2002 ASM in Adelaide, and I component in the delivery of excellent the specialty? remember being very much impressed patient-centred health care. Radiology by the traditions and solid organisation Radiology, or medical imaging in the is moving along a trajectory from an ‘art’ of the College. During my years as a broader sense, has become a very to a ‘science’, from producing ‘pretty member of the board of directors of the broad, horizontally integrated field, images’ to quantitative data sets. ESR, I have had several meetings with cross-linking with many, if not most Our communication with clinicians College representatives, in particular other specialties in medicine. This is is moving away from descriptive with the College's President, Dr Lance a great strength and offers wonderful reports in flowery prose, towards Lawler. opportunities for research. Conversely, standardised, structured reporting. the time is long gone that imaging These developments will force I strongly believe that for a medical could be considered the exclusive radiologists to transmogrify their practitioner, engagement with their domain of radiology. Many of our ‘analogue’ minds to the requirements professional organisation is important, clinical colleagues have discovered the of a digital, quantitative and research- both for individual professional potential of performing imaging-driven driven working environment. development and growth, and perhaps research and have learnt to explore the even more importantly, to engage in These changes are also reflected in the potential for using quantitative imaging the training of junior radiologists. It is spectrum of what we do as radiologists: biomarkers. our responsibility to ensure that the the focus has shifted away from next generation of radiologists has a We as radiologists are by no means any performing brilliant feats of diagnostic future that will be just as exciting and longer the sole custodians of imaging wizardry to the more mundane tasks productive as the professional career equipment or even of image analysis of accurately staging and following up that my generation has had until now. software. It is therefore of paramount patients with known diseases. continued over... Volume 16 No 4 I September 2020 21
Features Thanks to advancements in medicine, The future of medicine is research- some previously fatal diseases have driven, and the engagement of been reduced to chronic conditions. radiologists will help us to grow, as The growth of precision medicine is individuals and as doctors. Ideally, likely to become a key issue in how we through the CRRC, we can help to perform and interpret imaging studies. create and develop a culture so that Radiology plays a much more important radiologists can be a part of, or even role in the diagnosis, follow-up and take the lead in, imaging-driven research outcome prediction of patients with studies. chronic disorders (all kinds of cancer, Importantly, through research, we can degenerative disorders, inflammatory attract the best and brightest young diseases) by developing biomarkers minds to our discipline, and offer based on volumetric measurements, them perspectives in academic and perfusion studies (blood flow), professional development. spectroscopy (metabolic information), hybrid imaging (molecular information) and functional studies. The Royal Australian and New Zealand College of Radiologists® The Faculty of Radiation Oncology 22 Inside News
Education RANZCR Workshops, Courses and Events 2020–2021 As members are aware, the COVID-19 Confirmed topics and dates ESTRO Radiobiology Course pandemic has had a significant impact on public health, social wellbeing Clinical Radiology Faculty Forum An introduction to radiation biology and the economy. There has been 8 October 6–7.30 pm AEDT as applied to radiotherapy, focusing widespread cancellation of conferences on technology, biology and molecular Radiation Oncology Faculty Forum and meetings in line with current oncology. The ESTRO Radiobiology 9 October 2–3.30 pm AEDT government guidelines. Course has been postponed to 15–18 Imaging Emergencies of the Vascular April 2021. Trainees who have already The College’s COVID-19 Taskforce System 14 October 8–9 am AEDT registered and cannot attend the new and the Board of Directors have been dates will be issued a full refund. monitoring the situation closely to To register and for further information foresee and mitigate any risks to please visit the Events Page on Register here! members, staff and general community. our website: www.bit.ly/ESTROBasic www.ranzcr.com/whats-on/events Unfortunately, this has meant we have had to postpone some of our Further topics will be released shortly. upcoming events. This has been done If you have any questions relating bearing in mind that social distancing New Zealand Branch Annual to any College events please restrictions may continue well into the Scientific Meeting don’t hesitate to contact the end of this year with strict restrictions Conferences and Events team at The NZ ASM has been postponed to on international travel as well as mass events@ranzcr.edu.au 6–8 August 2021, to be held at the gatherings. InterContinental Hotel, Wellington. RANZCR Webinar Series RANZCR Annual The Conferences and Events team Scientific Meeting are working on running a series of The ASM has been postponed to educational webinars in the coming 16–19 September 2021, to be held at the months. Melbourne Convention and Exhibition If you would like to suggest a webinar Centre. topic, please don’t hesitate to email: For more information on RANZCR2021 events@ranzcr.edu.au visit our website: www.ranzcr2021.com Volume 16 No 4 I September 2020 23
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