Digital and Computational Cytology: What Is in the Horizon - Guest Editor: Jianyu Rao, Los Angeles, CA - Karger Publishers
←
→
Page content transcription
If your browser does not render page correctly, please read the page content below
65 | 4 | 21 ISBN
978–3–318–06673–6
Digital and Computational Cytology:
What Is in the Horizon
Guest Editor: Jianyu Rao, Los Angeles, CA
The International
L AC A D E M
NA Y
I N T E R N AT I O
OF
C Y TO LO G
Academy of Cytology
HE
T Y
...
... 19 5 7
Tentative IAC The role of cytology in complex
Examination sites CSF diagnostics
14. October 2021
Cartagena, Colombia Dr. Ondrej Sobek, Laboratory for CSF,
Saturday, 25. September 2021 Neuroimmunology, Pathology and
XXX Congreso De La Sociedad Latinoameri- Special Diagnostics, Topelex sro. Prague,
cana De Citopatologia Czech Republic
IV Congreso Del Capitulo De Citopatologia
De La Asociacion Colombiana De Patologia
Further IAC Events
Wrocław, Poland
Tuesday, 05. October 2021 IAC Annual General Meeting 2021
43rd European Cytology Congress 2021 Friday, 17. September 2021
Virtual Meeting on-line
Paris, France
Tuesday, 16. November 2021 IAC International Congress &
Annual General Meeting 2022
21st International Congress of Cytology &
IAC webinars the 70th Annual Scientific Meeting of the
American Society of Cytopathology
Lung Cytology 14.–19. November 2022
08. July 2021 Baltimore, USA
Dr. Maria D. Lozano Escario, Navarra Cancer
Center, Universidad de Navarra,
Pamplona, Spain
For more information visit www.cytology-iac.org EA21091
Associate Prof. Andrew S. Field Prof. Fernando Schmitt
MB BS(Hons), FRCPA, FIAC, MD, PhD, FIAC
Diploma of Cytopathology (RCPA) General Secretary
President
MI21002
Acta Cytologica
L AC A D E M
NA
I N T E R N AT I O
Y
OF
C Y TO LO
HE
The Journal of Clinical Cytology and Cytopathology
G
T Y
... ...
19 5 7
Founded 1957 by George L. Wied
Continued 2004–2013 by Marluce Bibbo
Editor-in-Chief
Kari J. Syrjänen – SMW Consultants Ltd., Turku, Finland
Associate Editors
Massimo Bongiovanni – SYNLAB Pathology SA, Lausanne, Switzerland
Lukas Bubendorf – University Hospital Basel, Basel, Switzerland
Lan Chen – Department of Pathology, Beijing Hospital, Beijing, China
Edmund S. Cibas – Brigham and Women’s Hospital, Boston, MA, USA
Andrew S. Field – St Vincent’s Hospital, Sydney, NSW, Australia
Kusum Kapila – Kuwait University Faculty of Medicine, Kuwait-City, Kuwait
Ivana Kholová – Tampere University Hospital, Tampere, Finland
Adhemar Longatto-Filho – University of Minho School of Health Sciences, Braga, Portugal
Robert Y. Osamura – Keio University School of Medicine, Kawasaki-ku, Japan
Fernando C. Schmitt, University of Porto, Porto, Portugal
Pio Zeppa – Azienda Ospedaliera Universitaria, Salerno, Italy
Honorary Editor
Marluce Bibbo – Jefferson University Hospital, Philadelphia, PA, USA
Editorial Board
Mousa A. Al-Abbadi – University of Jordan School of Medicine, Amman, Jordan
Syed Z. Ali – The Johns Hopkins Hospital, Baltimore, MD, USA
Zubair W. Baloch – Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Beata Bode-Lesniewska – University Hospital Zurich, Zurich, Switzerland
Sule Canberk – University of Porto, Porto, Portugal
Ashish Chandra – St Thomas’ Hospital, London, UK
Nikolaos Chantziantoniou – CellPathology Plus, Richmond Hill, ON, Canada
Angela Chong – Singapore General Hospital, Singapore, Singapore
Beatrix Cochand-Priollet – Cochin Hospital, Paris, France
Immacolata Cozzolino – University of Naples, Naples, Italy
Peter Dalquen – University Hospital Basel, Sissach, Switzerland
Ben Davidson – Oslo University Hospital, Oslo, Norway
Udupi S. Dinesh – Sri Dharmasthala College of Medical Sciences and Hospital, Dharwad, India
Hormoz Ehya – Fox Chase Cancer Center, Philadelphia, PA, USA
Marianne Engels – University Hospital Cologne, Cologne, Germany
Guido Fadda – Foundation “Agostino Gemelli” University Hospital, Rome, Italy
Annabelle Farnsworth – Douglass Hanly Moir Pathology, North Ryde, NSW, Australia
Pinar Firat – Istanbul University Faculty of Medicine, Istanbul, Turkey
(Continued on next page)
Printed in Germany on acid-free and non-aging paper
(ISO 9706) by Printec Offset, medienhaus, Kassel
(Continued)
Franco Fulciniti – Istituto Cantonale di Patologia, Locarno, Switzerland
Rosario Granados Carreño – Hospital Universitario de Getafe, Madrid, Spain
Shirley E. Greening – International Academy of Cytology, Philadelphia, PA, USA
Philip Ip – Queen Mary Hospital, Hong Kong, SAR
Deepali Jain – All India Institute of Medical Sciences, New Delhi, India
Walid E. Khalbuss – NGHA King Abdulaziz Medical City, Riyadh, Saudi Arabia
Jerzy Klijanienko – Institut Curie, Paris, France
Tadao K. Kobayashi, – Osaka University Graduate School of Medicine, Osaka, Japan
Britt-Marie Ljung – University of California Comprehensive Cancer Center, San Francisco, CA, USA
Zahra Maleki – The Johns Hopkins Hospital, Baltimore, USA
Pamela M. Michelow – University of Witwatersrand, Johannesburg, South Africa
Maria Nasioutziki – University of Thessaloniki, Medical School Aristotle, Thessaloniki, Greece
Ritu Nayar – Northwestern Memorial Hospital, Chicaco, IL, USA
Binnur Önal – Cinnah Cadessi, Ankara, Turkey
Bo Ping – Fudan University Shanghai Cancer Center, Shanghai, China
Álvaro P. Pinto – Boston Medical Center, Boston, MA, USA
Aruna Prayaga – Nizam’s Institute of Medical Sciences, Hyderabad, India
Marc Pusztaszeri – Hôpitaux Universitaires de Genève, Geneva, Switzerland
Samreung Rangdeang – Chiang Mai University Faculty of Medicine, Chiang Mai, Thailand
Olaf Reich – Medizinische Universität Graz, Graz, Austria
Alenka Repše-Fokter, Celje General Hospital, Celje, Slovenia
Esther D. Rossi – Catholic University of Sacred Heart, Rome, Italy
Mauro A. Saieg – Santa Casa Medical School, Sao Paolo, Brazil
Torill Sauer – UiO Institute of Clinical Medicine, Nordbyhagen, Norway
Spasenija Savic – University Hospital Basel, Basel, Switzerland
Pawel T. Schubert – Stellenbosch University & NHLS, Tygerberg, South Africa
Irena Shabalova – Russian Medical Academy of Postgraduate Education, Moscow,
Russian Federation
Momin T. Siddiqui – New York Presbyterian Hospital, New York, NY, USA
Lambert Şkoog – Karolinska Hospital, Stockholm, Sweden
John H.F. Smith – Lodge Moor, Sheffield, UK
Yuko Sugiyama – Cancer Institute Hospital, Tokyo, Japan
Eszter Szekely – Semmelweis University, Budapest, Hungary
Nobuhiro Takeshima – Cancer Institute Hospital, Tokyo, Japan
Edneia M. Tani – Karolinska Institute and Hospital, Stockholm, Sweden
Esperanza Teuzaba – Institution Patolab Rx Ltda, Bogota, Colombia
Helen J. Trihia – Metaxas Cancer Hospital, Piraeus, Greece
Gary Tse – Prince of Wales Hospital, Hong Kong, Hong Kong, SAR
Laszlo Vass – Flor Ferenc Hospital of Pest County, Kistarcsa, Hungary
Guang-Ping Wu – China Medical University, Shenyang, China
Junior Editorial Board
Ricardo R. Lastra – University of Chicago Medical Center, Chicago, IL, USA
Yurina Miki – Guy’s and St Thomas’ NHS Foundation Trust, London UK
Joerg Schwock – University Health Network, Toronto, CA
José Cândido Xavier Jr – Unisalesiano Araçatuba, Brazil
© 2021 S. Karger AG, Basel
www.karger.com
karger@karger.com
National and Regional Societies and Editors
A L AC A D E M
ON
YO
I N T E R N AT I
International Editor
F C Y TO LO G
Kari J. Syrjänen
HE
T Y
... ...
19 5 7
The journal is also the official periodical of the following
National and Regional Societies National and Regional Editors
Albanian Society of Cytology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Majlinda Buba Ikonomi
Sociedad Argentina de Citologia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mercedes Gamboni
Australian Society of Cytology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Andrew S. Field
Société Belge de Cytologie Clinique/Belgische Vereniging voor Klinische Cytologie . . . . . . . . . . . . Claire Bourgain
Sociedade Brasileira de Citopatologia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Álvaro Piazzeta Pinto
British Society for Cytopathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Karin Denton
The Canadian Society of Cytology/Société Canadienne de Cytologie . . . . . . . . . . . . . . . . . . . . . Harmanjatinder S. Sekhon
Ceská spolecnost pro klinickou cytologii . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Jaroslava Dušková
Sociedad Chilena de Citologia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Miguel Socias
Chinese Society of Cytopathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Dongge Liu
Colombian Association of Pathology, Section of Cytopathology, ASOCOLPAT . . . . . . . . . . . . . . . Esperanza Teuzaba Torres
Croatian Society for Clinical Cytology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Vesna Mahovlić
Danish Society of Pathologic Anatomy and Clinical Cytology . . . . . . . . . . . . . . . . . . . . . . . . . . Doris Schledermann
Deutsche Gesellschaft für Zytologie . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Dietmar Schmidt
Dutch Society of Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Elle K.J. Risse
European Federation of Cytological Societies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Martin Tötsch
Sociedad Española de Citologia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mercedes Santamaría Martínez
Finnish Society of Clinical Cytology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Leena Krogerus
La Société Française de Cytologie Clinique . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Marie-Cécile Vacher Lavenu
Hellenic Society of Clinical Cytology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ekatreini Politi
Hong Kong Society of Cytology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Nancy Yuen
Magyar Pathologusok Tarsasaga-Cytodiagnosztikai Sectio . . . . . . . . . . . . . . . . . . . . . . . . . . . . László Vass
Indian Academy of Cytologists . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Meherbano M. Kamal
Iranian Society of Clinical Cytology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mansour Mehzad
Società Italiana di Citologia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Patricia Maioli
Società Italiana di Anatomia Patologica Citodiagnostica . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Sonia Prandi
Japanese Society of Clinical Cytology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Kenji Yanou
Kazakhstan Association of Clinical Cytologists . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Leyla B. Djansugurova
Korean Society for Cytopathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Soon Won Hong
Sociedad Latino-Americana de Citología . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Luiz Martins Collaco
Mexican Academy of Cytopathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Oralia Barboza Quintana
New Zealand Society of Cytology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Peter N.G. Fitzgerald
Norsk Forening for Klinisk Cytologi . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ben Davidson
Österreichische Gesellschaft für Zytologie . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Peter Regitnig
Sociedad Peruana de Citologia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Delia M. Jara Facundo
Sociedade Portuguesa de Citologia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Fernando C. Schmitt
Romanian Society of Cytology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Irina Ecaterina Julea
Russian Association of Clinical Cytologists . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Naum A. Shapiro
Schweizerische Gesellschaft für Klinische Cytologie . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Lukas Bubendorf
Slovenian Society of Clinical Cytology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Alenka Repse Fokter
Suid-Afrikaanse Vereniging vir Kliniese Sitologie/South African Society of Clinical Cytology . . . . . . . Pamela M. Michelow
Svensk Förening för Klinisk Cytologi . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Edneia M. Tani
Taiwan Society of Clinical Cytology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Chiung-Ru Lai
Turkish Society of Cytopathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Özlem Aydin
Sociedad Uruguaya de Citologia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Carmen Alvarez-Santín
West African Society of Cytology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Jaiyeola Thomas
© 2021 S. Karger AG, Basel
www.karger.com
karger@karger.comJournal Information
Aims and Scope
With articles offering an excellent balance between clinical cytology and cytopathology,
Acta Cytologica fosters the understanding of the pathogenetic mechanisms behind cyto-
morphology and thus facilitates the translation of frontline research into clinical practice. As
the official journal of the International Academy of Cytology and affiliated to over 50 na-
tional cytology societies around the world, Acta Cytologica evaluates new and existing diag-
Guidelines for Authors nostic applications of scientific advances as well as their clinical correlations. Original papers,
We strongly encourage authors to read
the Guidelines for Authors at
review articles, meta-analyses, novel insights from clinical practice, and letters to the editor
www.karger.com/acy_guidelines prior to cover topics from diagnostic cytopathology, gynecologic and non-gynecologic cytopathol-
submitting an article ogy to fine needle aspiration, molecular techniques and their diagnostic applications. As the
perfect reference for practical use, Acta Cytologica addresses a multidisciplinary audience
practicing clinical cytopathology, cell biology, oncology, interventional radiology, otorhino-
laryngology, gastroenterology, urology, pulmonology and preventive medicine.
Journal Contact
For questions or comments, please contact
the persons responsible who can be found at
http://www.karger.com/Journal/Contact/254338
ISSN Print Edition: 0001–5547 Subscription Orders: Subscription Rates: Subscriptions run for a full
ISSN Online Edition: 1938–2650 Orders can be placed at agencies, bookstores, calendar year. Prices are given per year.
or directly with the Publisher.
Journal Homepage: www.karger.com/acy Personal subscription:
Bibliographic Indices: This journal is regularly listed S. Karger AG
Print or Online Print+Online combined
in bibliographic services, including Current Con- Medical and Scientific Publishers
CHF 493.00 CHF 567.00
tents® and PubMed/MEDLINE. Allschwilerstrasse 10
EUR 452.00 EUR 520.00
CH–4009 Basel
USD 524.00 USD 603.00
Publication Data: Acta Cytologica is published 6 Switzerland
times a year. Volume 65 with 6 issues appears in postage and handling
t: +41 61 306 11 11
2021. (added to print and print+online)
f: +41 61 306 12 34
CHF 52.80 Europe, CHF 74.40 Overseas
e: karger@karger.com
Copyright: © 2021 S. Karger AG, Basel (Switzerland). EUR 48.00
w: www.karger.com
All rights reserved. No part of this publication may be USD 72.00
translated into other languages, reproduced or uti- (for courier services only:
lized in any form or by any means, electronic or me- Allschwilerstrasse 10 Institutional subscription:
chanical, including photocopying, recording, micro- CH–4055 Basel)
Print or Online Print+Online combined
copying, or by any information storage and retrieval
CHF 985.00 CHF 1133.00
system, without permission in writing from the pub- Change of Address:
EUR 904.00 EUR 1040.00
lisher. Both old and new addresses should be sent
USD 1048.00 USD 1205.00
to the subscription source.
Disclaimer: The statements, opinions and data con- postage and handling
tained in this publication are solely those of the indi- (added to print and print+online)
vidual authors and contributors and not of the pub- CHF 66.00 Europe, CHF 93.00 Overseas
lisher and the editor(s). The appearance of advertise- EUR 60.00
ments in the journal is not a warranty, endorsement, USD 90.00
or approval of the products or services advertised or
of their effectiveness, quality or safety. The publisher Back Volumes and Single Issues: Information on
and the editor(s) disclaim responsibility for any injury availability and prices of single print issues and print
to persons or property resulting from any ideas, or electronic back volumes can be obtained from
methods, instructions or products referred to in the Customer Service at service@karger.com.
content or advertisements.
© 2021 S. Karger AG, Basel
www.karger.com
karger@karger.comDeepen your understanding
Titel
of AI‘s role in cytopathology
FREE
ENROLLMENT!
courses.karger.com
Digital and Computational
Cytology
The role of artificial intelligence in pathology can be a complex
topic. However, it is a vitally important one. This 30-minute, free-
to-access course is designed to deepen your understanding
of the material in Acta Cytologica issue 04, 2021. Students will
be able to test their understanding of terminology used, and prac-
tice creating a data set of slides.
IA21067_280
Authors:
Ewen McAlpine
Pamela Michelow
RESEARCHRelevant information
close to you
Become more efficient with the AI-based
discovery tool
* Karger Publishers collaborates with the award-winning
analytics company Quertle to support in the task of
curation. The Artificial Intelligence (AI)-based discovery
tool Qinsight simplifies the research process.
KI20249Pathology and
Cell Biology
KI20280_210x280
karger.com/cellbiologyFREE
ACCESS
Topic Article Package:
COVID-19
karger.com/
IA21001
COVIDIndispensable reading in cytopathology and beyond
The Journal of Clinical Cytology and Cytopathology
The Journal of Clinical Cytology and Cytopathology
Editor-in-Chief
Kari J. Syrjänen,
Turku l
na
L AC A D E M
l jour
NA
Y
I N T E R N AT I O
OF
Official Periodical
C YTO LO G
of the International
ia
Academy of Cytology
fic
HE
of
T Y
...
... 19 5 7
The of IAC
The official Journal of
Founded in 1957, Acta Cytologica was the first and, for decades, the only Selected contributions
cytopathology journal. As the official journal of the International Academy • A Review of the Use of Fine-Needle Aspiration Biopsy of Mammary
of Cytology and affiliated to nearly 50 national cytology societies around Tumors for Diagnosis and Research: Tani, E.; Fuentes-Martinez, N.; Skoog, L.
the world, it remains the only truly international journal in the field. This (Stockholm)
makes Acta Cytologica unique in its global coverage and geographically • Two Fortuitous Papers in 1917 That Conceived Diagnostic
representative submissions. With the published original studies, reviews, Cytopathology: Chantziantoniou, N. (Doha)
meta-analyses, carefully selected case reports, and letters to the editor • Criticism of the Pap Smear as a Diagnostic Tool in Cervical Cancer
which maintain a good balance between clinical cytology and cytopa- Screening: Schneider, V. (Freiburg)
thology, Acta Cytologica fosters the understanding of the pathogenetic • George Papanicolaou’s Efforts to Develop Novel Cytologic Methods for
mechanisms behind cytomorphology. The journal thus facilitating the the Early Diagnosis of Endometrial Carcinoma: Austin, R.M. (Pittsburgh, PA)
translation of cutting-edge research into clinical practice. Acta Cytologica • Two Landmark Studies Published in 1976/1977 Paved the Way for the
Recognition of Human Papillomavirus as the Major Cause of the Global
covers topics from diagnostic cytopathology, gynecologic and nongyne-
Cancer Burden: Syrjänen, K.J. (Helsinki/Barretos)
cologic cytopathology to fine needle aspiration, molecular techniques
• The Bethesda System for Reporting Cervical Cytology: A Historical
and their diagnostic applications, thus addressing a multidisciplinary au-
Perspective: Nayar, R. (Chicago, IL); Wilbur, D.C. (Boston, MA)
dience, far beyond the practicing cytopathologists and cytologists.
• Expectations and Projections for the Future of Nongynecolgical Cytology
10 Years Ago: Did They Materialize and How Did We Do?: Schmitt, F.C.
(Porto); Vielh, P. (Dudelange)
Acta Cytologica
Founded: 1957
Category: Clinical Research
Field of Interest: Cytology
Listed in bibliographic services, including:
PubMed/MEDLINE, Web of Science,
Google Scholar, Scopus, Embase
2019: Volume 63
6 issues per volume
Language: English
KF 19001
ISSN 0001–5547
e-ISSN 1938–2650 More information at w w w. karger.com/ac yDigital and Computational Cytology: What Is in the Horizon There is both hope and hype around the potential of artificial in- telligence (AI) and machine learning to transform the discipline of cytopathology. On one extreme, there are claims that medical pro- fessionals will no longer be required to analyze pathology slides. On the other extreme, there are claims that AI‘s role has limited or no clinical value. The truth is somewhere in the middle, and AI will likely become a valuable companion to the cytopathologist who knows how to use and interpret it correctly. This special issue is a first step to educate our readers to become just such a cytopathologist. It includes a mixture of review and original research of application of AI systems for the cytological diagnosis of various organ systems. While primarily of interest to cytopathologists and cytotechnologists, it will also be interesting reading for pathologists of all fields and to those working in AI and health care.
You can also read
