COVID-19 Current Awareness Bulletin 26th March 2020 - Produced by the NHS Staff Library

COVID-19 Current Awareness Bulletin

           26th March 2020

        Produced by the NHS Staff Library,

        Mid Yorkshire Hospitals NHS Trust

            midyorks.library.pgh@nhs.net

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Policy & guidance
Professional bodies
Journals
Research articles
Scientific press
Information resources

Policy & Guidance
Department of Health and Social Care
Updates
Latest Guidance on the Government response
Number of coronavirus (COVID-19) cases and risk in the UK
COVID-19: guidance for health professionals
Guidance
The Exercise of Commissioning Functions by the NHS Commissioning Board (Coronavirus)
Directions 2020
Directions given to the National Health Service Commissioning Board.

Coronavirus bill: summary of impacts
A summary of impacts relating to clauses within the coronavirus bill.

Coronavirus (COVID-19): letter from the Minister of State for Care to recruitment agencies
The letter calls upon recruitment agencies in the health and care sector to work in
constructive partnership with the NHS during the coronavirus (COVID-19) pandemic.

Coronavirus (COVID-19): ventilator supply specification
Specification of rapidly manufactured ventilator systems needed as part of the response to
coronavirus (COVID-19).

Medicines that cannot be parallel exported from the UK
Sets out medicines that cannot be parallel exported from the UK because they are needed
for UK patients.

Coronavirus (COVID-19): hospital discharge service requirements
Sets out how health and care systems and providers should change their discharging
arrangements and the provision of community support during the coronavirus situation.

Initiatives
Vaccine trials among recipients of £20 million coronavirus research investment
Trials of new coronavirus vaccine among 6 projects to receive share of £20 million.

New technology challenge to support people who are isolating
£500,000 of funding is available for technology companies who come up with digital support
solutions for people who need to stay at home because of coronavirus

UK launches whole genome sequence alliance to map spread of coronavirus
The £20 million investment could help public health agencies combat COVID-19 and future
pandemics.

Public Health England
Updates
COVID-19: guidance for employees, employers and businesses

Coronavirus (COVID-19): guidance for health professionals and other organisations

COVID-19: background information
Information on COVID-19 including epidemiology, virology and clinical features.

Guidance
COVID-19: guidance on social distancing and for vulnerable people
Guidance on social distancing for everyone in the UK, including children, and protecting
older people and vulnerable people.

COVID-19: infection prevention and control
Guidance on infection prevention and control for COVID-19.

COVID-19: guidance on shielding and protecting people defined on medical grounds as
extremely vulnerable
Information for shielding and protecting people defined on medical grounds as extremely
vulnerable from COVID-19.

COVID-19: evaluation of commercially available diagnostic products
Information on how Public Health England (PHE) is evaluating the various commercially
available COVID-19 diagnostics products.

COVID-19: guidance for sampling and for diagnostic laboratories
Information for clinical diagnostic laboratories regarding safety, sampling and packaging
specimens associated with COVID-19.

COVID-19: guidance for primary care

NHS England
Specialty guides
Guides for patient management during the coronavirus pandemic

Health information and advice

Coronavirus guidance for clinicians and NHS managers

NICE
Rapid guidelines and evidence reviews

COVID-19 rapid guideline: critical care

COVID-19 rapid guideline: dialysis service delivery

COVID-19 rapid guideline: delivery of systemic anticancer treatments

NHS Health Education England
Knowledge for Healthcare
Links to information on COVID-19 from trusted sources

eLearning for Healthcare
Coronavirus (COVID-19) programme
The programme includes key materials to help the health and care workforce respond to
Coronavirus. The programme is freely available – no registration or log in
required: https://portal.e-lfh.org.uk/Component/Details/604722

MHRA
MHRA guidance on Coronavirus (COVID-19)
Guidance for industry, prioritising;
      Supporting and authorising the development of vaccines
      Clinical trials of new medicines
      Managing the supply of medicines and healthcare products

NHS Confederation
COVID-19
Regularly updated information and support for health and care leaders on COVID-19.

How CCGs can support their primary care networks and practices in light of COVID-19:
member briefing

NHS Employers
COVID-19 guidance for NHS workforce leaders

Health Research Authority
COVID-19: Guidance for sponsors, sites and researchers

Medical Research Council
COVID-19 reports

Public Response to UK Government Recommendations on COVID-19: Population Survey, 17-
18 March 2020

Evidence of initial success for China exiting COVID-19 social distancing policy after achieving
containment

Impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and
healthcare demand

World Health Organization
Coronavirus disease (COVID-2019) situation reports

Research and development

Media briefings

Professional Bodies
BMA
Covid-19 hub

COVID-19: your terms and conditions
Answers to some of the questions doctors have about the impact of COVID-19 on
contract terms and conditions.

COVID-19: medical students requested to work in the NHS
Guidance for medical students on medical schools and trusts offering the opportunity to
take on contracts of employment in the NHS due to COVID-19.

British Thoracic Society
COVID-19: information for the respiratory community

General Medical Council
Coronavirus information and advice

Royal College of Emergency Medicine
Supporting doctors in the event of a Covid19 Epidemic in the UK

Coronavirus (COVID-19) guidance for clinicians

Royal College of Nursing
COVID-19 (coronavirus)

Royal College of Obstetricians and Gynaecologists
Coronavirus (COVID-19) infection and pregnancy UPDATED

Royal College Of Paediatrics and Child Health
COVID-19 information page

COVID-19 - guidance for paediatric services

Royal College of Physicians
Specialty-specific guidance on aspects of clinical care and treatment for COVID-19

Journals
An NHS Athens account may be required for full text access, register here.

BMJ
Coronavirus (covid-19): Latest news and resources
This page collects all BMJ coverage of the coronavirus outbreak from across the BMJ's
journals and learning resources. All articles and resources are freely available.

News—Trials of four potential treatments to generate “robust data” of what works
WHO is to coordinate an international study of treatments
News—UK lockdown is “crucial” to saving lives, say doctors and scientists
Medical leaders have backed UK government’s decision to impose new restrictions
News—Sixty seconds on . . . anosmia
WHO is examining how common it might be for infected people to experience a loss
of smell or taste
News—Most patients require mechanical ventilation in first 24 hours of critical care
Two thirds of covid-19 patients had mechanical ventilation within 24 hours of
admission

News—Doctors are given new guidelines on when to admit patients to critical care
Decisions about whether to admit patients with covid-19 to critical care should
consider the medical benefit

The Lancet
Guidance
Covid-19 Resource Centre

COVID-19: protecting health-care workers

Articles
Health security capacities in the context of COVID-19 outbreak: an analysis of International
Health Regulations annual report data from 182 countries

Immunosuppression for hyperinflammation in COVID-19: a double-edged sword?

COVID-19 in Europe: the Italian lesson

Mass gathering events and reducing further global spread of COVID-19: a political and public
health dilemma

Scientific and ethical basis for social-distancing interventions against COVID-19

COVID-19 and medical education

Cancer care in the time of COVID-19

Treatment for severe acute respiratory distress syndrome from COVID-19

National UK programme of community health workers for COVID-19 response

Early in the epidemic: impact of preprints on global discourse about COVID-19 transmissibility

Management of pregnant women infected with COVID-19

COVID-19 in a patient with chronic lymphocytic leukaemia

Deciphering the power of isolation in controlling COVID-19 outbreaks

New England Journal of Medicine
A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
Conclusions: In hospitalized adult patients with severe Covid-19, no benefit was observed
with lopinavir–ritonavir treatment beyond standard care.

Audio Interview: New Research on Possible Treatments for Covid-19

Fair Allocation of Scarce Medical Resources in the Time of Covid-19

The Toughest Triage — Allocating Ventilators in a Pandemic

Journal of the American Medical Association
Coronavirus Resource Center

Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID 19 in Italy

Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to
Coronavirus Disease 2019

Publisher bundles (free to access)
Coronavirus (COVID-19): articles and resources Mark Allen Healthcare journals.

Novel Coronavirus Information Center Elsevier

Covid-19: Novel Coronavirus Content Free to Access Wiley Online Library

SARS-CoV-2 and COVID-19 Springer Nature

COVID-19: Novel Coronavirus Content Free to Access Taylor & Francis

Access to OUP resources on COVID-19 Oxford University Press

Research Articles
COVID-19, an emerging coronavirus infection: advances and prospects in designing and
developing vaccines, immunotherapeutics, and therapeutics
Authors: Kuldeep Dhama et al.
Source: Human Vaccines & Immunotherapeutics (2020)

Could chloroquine /hydroxychloroquine be harmful in Coronavirus Disease 2019 (COVID-19)
treatment?
Authors: Maurizio Guastalegname, Alfredo Vallone
Source: Clinical Infectious Diseases (2020)

Covid-19: Protecting Worker Health
Authors: Sean Semple,John W Cherrie
Source: Annals of Work Exposures and Health (2020)

A COVID-19 Transmission within a family cluster by presymptomatic infectors in China

Authors: Guoqing Qian,Naibin Yang et al.
Source: Clinical Infectious Diseases (2020)

COVID-19 Treatment: A Review of Early and Emerging Options
Authors: Erin K McCreary et al.
Source: Open Forum Infectious Diseases (2020)

Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19)
Authors: Li Guo, Ph.D,Lili Ren et al.
Source: Clinical Infectious Diseases (2020)

COVID-19: a fast evolving pandemic
Author: Jimmy Whitworth
Source: Transactions of The Royal Society of Tropical Medicine and Hygiene (2020)

High-dose intravenous immunoglobulin as a therapeutic option for deteriorating patients
with Coronavirus Disease 2019
Authors: Wei Cao, M.D, Xiaosheng Liu et al.
Source: Open Forum Infectious Diseases (2020)

ERA-EDTA sharing Milan experience on coronavirus management in dialysis centres
Authors: Mario Cozzolino on behalf of the ERA-EDTA Council
Source: Clinical Kidney Journal (2020)
Public health measures to slow community spread of COVID-19
Authors: Benjamin J Cowling, Allison Aiello
Source: The Journal of Infectious Diseases (2020)

Recommendations for the prevention, mitigation and containment of the emerging SARS-
CoV-2 (COVID-19) pandemic in haemodialysis centres
Authors: Carlo Basile, Christian Combe et al.
Source: Nephrology Dialysis Transplantation (2020)

COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing
infection and progression
Authors: Dan Zhou, Sheng-Ming Dai et al.
Source: Journal of Antimicrobial Chemotherapy (2020)

Asymptomatic carrier state, acute respiratory disease, and pneumonia due
to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths
Authors: Chih-Cheng Lai et al.
Source: Journal of Microbiology, Immunology and Infection (2020)

Computers and viral diseases. Preliminary bioinformatics studies on the design of a
synthetic vaccine and a preventative peptidomimetic antagonist against the SARS-CoV-2
(2019-nCoV, COVID-19) coronavirus
Author: Robson, B
Source: Computers in Biology and Medicine (2020)

Genetic diversity and evolution of SARS-CoV-2
Author: Phan, T
Source: Infection, Genetics and Evolution; Volume 81; July 2020

Potential role of inanimate surfaces for the spread of coronaviruses and their inactivation
with disinfectant agents
Author: Kampf, G
Source: Infection Prevention in Practice; Volume 2 (Iss 2); 2020

Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis
Authors: Lippi, G et al
Source: Clinica Chimica Acta; Volume 505; June 2020; PP 190-191

CT manifestations of coronavirus disease-2019: A retrospective analysis of 73 cases by
disease severity
Authors: Kai-Cai Liu et al.
Source: European Journal of Radiology; Volume 126; May 2020

Policies on the use of respiratory protection for hospital health workers to protect
from coronavirus disease (COVID-19)
Authors: Chughtai A et al.
Source: International Journal of Nursing Studies; Volume 105; May 2020

Molecular immune pathogenesis and diagnosis of COVID-19

Authors: Xiaowei Li et al.
Source: Journal of Pharmaceutical Analysis (2020)
A review of the 2019 Novel Coronavirus (COVID-19) based on current evidence
Authors: Li-sheng Wang et al.
Source: International Journal of Antimicrobial Agents (2020)

The epidemic of 2019-novel-coronavirus (2019-nCoV) pneumonia and insights for emerging
infectious diseases in the future
Authors: Li JY et al.
Source: Microbes and Infection; Volume 22; Issue 2; March 2020; PP 80-85

Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal
agents
Authors: Kampf G et al.
Source: Journal of Healthcare Infection; Volume 104; Issue 3; PP 246-251

An NHS Athens account may be required for full text access, register here.
If you cannot access the full-text using your NHS Athens account please email us and
we will source the article for you.

Scientific Press
Nature
Covert coronavirus infections could be seeding new outbreaks
Scientists are rushing to estimate the proportion of people with mild or no symptoms who
could be spreading the pathogen.

New Scientist
Coronavirus: Latest news about the covid-19 pandemic

UK's scientific advice on coronavirus is a cause for concern

Can you catch the coronavirus twice? We don’t know yet

You could be spreading the coronavirus without realising you’ve got it

We haven’t identified any new drugs for severe covid-19 cases yet

Science
Coronavirus: Research, Commentary, and News

New blood tests for antibodies could show true scale of coronavirus pandemic

Information Resources
BMJ Best Practice
COVID-19
This topic is free to access and updated daily. It covers epidemiology, diagnosis and
management and gathers all international guidelines in one place.

Critical Care Reviews
Literature on SAR-CoV-2 published since the outbreak began in December 2019

Dynamed
COVID-19 (Novel Coronavirus)

PHE Knowledge and Library Services team
Finding the evidence: Coronavirus
PHE Knowledge and Library Services team has produced this page to help those working on
the current coronavirus outbreak, embed evidence-informed decision-making in their daily
practice. Most of the resources are freely accessible but some may ask for an OpenAthens
sign-in.

Trip Database
Evidence and grey literature – updated daily

Cochrane Special Collections
Coronavirus (COVID-19): evidence relevant to critical care
Coronavirus (COVID-19): infection control and prevention measures

Oxford COVID-19 Evidence Service
Centre for Evidence-Based Medicine

25th March:
          Supporting people with long-term conditions (LTCs) during national emergencies

24th March:

   What is the efficacy of standard face masks compared to respirator masks in
                  preventing COVID-type respiratory illnesses in primary care staff?

                 COVID-19 Signs and Symptoms Tracker

          UPDATED 24th March: What is happening to mortality during the COVID-19 outbreak?
                 Assessment of Mortality in the Covid-19 outbreak

                 See the latest mortality data update here

                 Assessment of the Global Covid-19 Case Fatality Rates

          23rd March:
                 Are there evidence-based ways of assessing dyspnoea (breathlessness) by telephone
                  or video?

          23rd March: Questions about ACEI and ARBs
                 Angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers in
                  COVID-19

          22nd March: Do weather conditions influence the transmission of the coronavirus (SARS-
          CoV-2)
                 Weather Condition influence on transmission of SARS-CoV-2

          20th March: Is there a connection between conjunctivitis and COVID-19?
                 Spreading SARS-CoV-2 through ocular fluids

Disclaimer:
While we make every possible effort to ensure that the information in this publication is accurate and up to
date at the time of publishing, we do not accept any responsibility for errors or omissions. Nor do we accept
any responsibility for loss or damage resulting from making use of this information. Links to third party
websites are provided for the convenience of users and we in no way endorse the contents, views or
information held on such sites.

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